                         SEQUENCE LISTING

<110>  Oxford University Innovation
 
<120>  Method

<130>  N408937WO

<150>  GB 1616565.6
<151>  2016-09-29

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  3996
<212>  DNA
<213>  Homo sapiens


<220>
<221>  cDNA sequence CNTNAP2-001 ENST00000361727 (isoform 1)
<222>  (1)..(3996)

<400>  1
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaactttaa gacgtctgaa      660

agtgaaggag taatcctgca cggagaagga cagcaaggag attacattac cttggaactg      720

aaaaaagcca agctggtcct cagtttaaac ttaggaagca accagcttgg ccccatatat      780

ggccacacat cagtgatgac aggaagtttg ctggatgacc accactggca ctctgtggtc      840

attgagcgcc aggggcggag cattaacctc actctggaca ggagcatgca gcacttccgt      900

accaatggag agtttgacta cctggacttg gactatgaga taacctttgg aggcatccct      960

ttctctggca agcccagctc cagcagtaga aagaatttca aaggctgcat ggaaagcatc     1020

aactacaatg gcgtcaacat tactgatctt gccagaagga agaaattaga gccctcaaat     1080

gtgggaaatt tgagcttttc ttgtgtggaa ccctatacgg tgcctgtctt tttcaacgct     1140

acaagttacc tggaggtgcc cggacggctt aaccaggacc tgttctcagt cagtttccag     1200

tttaggacat ggaaccccaa tggtctcctg gtcttcagtc actttgcgga taatttgggc     1260

aatgtggaga ttgacctcac tgaaagcaaa gtgggtgttc acatcaacat cacacagacc     1320

aagatgagcc aaatcgatat ttcctcaggt tctgggttga atgatggaca gtggcacgag     1380

gttcgcttcc tagccaagga aaattttgct attctcacca tcgatggaga tgaagcatca     1440

gcagttcgaa ctaatagtcc ccttcaagtt aaaactggcg agaagtactt ttttggaggt     1500

tttctgaacc agatgaataa ctcaagtcac tctgtccttc agccttcatt ccaaggatgc     1560

atgcagctca ttcaagtgga cgatcaactt gtaaatttat acgaagtggc acaaaggaag     1620

ccgggaagtt tcgcgaatgt cagcattgac atgtgtgcga tcatagacag atgtgtgccc     1680

aatcactgtg agcatggtgg aaagtgctcg caaacatggg acagcttcaa atgcacttgt     1740

gatgagacag gatacagtgg ggccacctgc cacaactcta tctacgagcc ttcctgtgaa     1800

gcctacaaac acctaggaca gacatcaaat tattactgga tagatcctga tggcagcgga     1860

cctctggggc ctctgaaagt ttactgcaac atgacagagg acaaagtgtg gaccatagtg     1920

tctcatgact tgcagatgca gacgcctgtg gtcggctaca acccagaaaa atactcagtg     1980

acacagctcg tttacagcgc ctccatggac cagataagtg ccatcactga cagtgccgag     2040

tactgcgagc agtatgtctc ctatttctgc aagatgtcaa gattgttgaa caccccagat     2100

ggaagccctt acacttggtg ggttggcaaa gccaacgaga agcactacta ctggggaggc     2160

tctgggcctg gaatccagaa atgtgcctgc ggcatcgaac gcaactgcac agatcccaag     2220

tactactgta actgcgacgc ggactacaag caatggagga aggatgctgg tttcttatca     2280

tacaaagatc acctgccagt gagccaagtg gtggttggag atactgaccg tcaaggctca     2340

gaagccaaat tgagcgtagg tcctctgcgc tgccaaggag acaggaatta ttggaatgcc     2400

gcctctttcc caaacccatc ctcctacctg cacttctcta ctttccaagg ggaaactagc     2460

gctgacattt ctttctactt caaaacatta accccctggg gagtgtttct tgaaaatatg     2520

ggaaaggaag atttcatcaa gctggagctg aagtctgcca cagaagtgtc cttttcattt     2580

gatgtgggaa atgggccagt agagattgta gtgaggtcac caacccctct caacgatgac     2640

cagtggcacc gggtcactgc agagaggaat gtcaagcagg ccagcctaca ggtggaccgg     2700

ctaccgcagc agatccgcaa ggccccaaca gaaggccaca cccgcctgga gctctacagc     2760

cagttatttg tgggtggtgc tgggggccag cagggcttcc tgggctgcat ccgctccttg     2820

aggatgaatg gggtgacact tgacctggag gaaagagcaa aggtcacatc tgggttcata     2880

tccggatgct cgggccattg caccagctat ggaacaaact gtgaaaatgg aggcaaatgc     2940

ctagagagat accacggtta ctcctgcgat tgctctaata ctgcatatga tggaacattt     3000

tgcaacaaag atgttggtgc attttttgaa gaagggatgt ggctacgata taactttcag     3060

gcaccagcaa caaatgccag agactccagc agcagagtag acaacgctcc cgaccagcag     3120

aactcccacc cggacctggc acaggaggag atccgcttca gcttcagcac caccaaggcg     3180

ccctgcattc tcctctacat cagctccttc accacagact tcttggcagt cctcgtcaaa     3240

cccactggaa gcttacagat tcgatacaac ctgggtggca cccgagagcc atacaatatt     3300

gacgtagacc acaggaacat ggccaatgga cagccccaca gtgtcaacat cacccgccac     3360

gagaagacca tctttctcaa gctcgatcat tatccttctg tgagttacca tctgccaagt     3420

tcatccgaca ccctcttcaa ttctcccaag tcgctctttc tgggaaaagt tatagaaaca     3480

gggaaaattg accaagagat tcacaaatac aacaccccag gattcactgg ttgcctctcc     3540

agagtccagt tcaaccagat cgcccctctc aaggccgcct tgaggcagac aaacgcctcg     3600

gctcacgtcc acatccaggg cgagctggtg gagtccaact gcggggcctc gccgctgacc     3660

ctctccccca tgtcgtccgc caccgacccc tggcacctgg atcacctgga ttcagccagt     3720

gcggattttc catataatcc aggacaaggc caagctataa gaaatggagt caacagaaac     3780

tcggctatca ttggaggcgt cattgctgtg gtgattttca ccatcctgtg caccctggtc     3840

ttcctgatcc ggtacatgtt ccgccacaag ggcacctacc ataccaacga agcaaagggg     3900

gcggagtcgg cagagagcgc ggacgccgcc atcatgaaca acgaccccaa cttcacagag     3960

accattgatg aaagcaaaaa ggaatggctc atttga                               3996


<210>  2
<211>  1331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CASPR2
<222>  (1)..(1331)

<400>  2

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn 
            580                 585                 590         


Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr 
        595                 600                 605             


Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro 
    610                 615                 620                 


Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val 
625                 630                 635                 640 


Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu 
                645                 650                 655     


Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile 
            660                 665                 670         


Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr 
        675                 680                 685             


Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr 
    690                 695                 700                 


Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly 
705                 710                 715                 720 


Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys 
                725                 730                 735     


Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp 
            740                 745                 750         


Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser 
        755                 760                 765             


Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu 
    770                 775                 780                 


Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala 
785                 790                 795                 800 


Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln 
                805                 810                 815     


Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro 
            820                 825                 830         


Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu 
        835                 840                 845             


Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn 
    850                 855                 860                 


Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp 
865                 870                 875                 880 


Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu 
                885                 890                 895     


Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly 
            900                 905                 910         


His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly 
        915                 920                 925             


Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly 
    930                 935                 940                 


Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile 
945                 950                 955                 960 


Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn 
                965                 970                 975     


Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser 
            980                 985                 990         


Asn Thr Ala Tyr Asp Gly Thr Phe  Cys Asn Lys Asp Val  Gly Ala Phe 
        995                 1000                 1005             


Phe Glu  Glu Gly Met Trp Leu  Arg Tyr Asn Phe Gln  Ala Pro Ala 
    1010                 1015                 1020             


Thr Asn  Ala Arg Asp Ser Ser  Ser Arg Val Asp Asn  Ala Pro Asp 
    1025                 1030                 1035             


Gln Gln  Asn Ser His Pro Asp  Leu Ala Gln Glu Glu  Ile Arg Phe 
    1040                 1045                 1050             


Ser Phe  Ser Thr Thr Lys Ala  Pro Cys Ile Leu Leu  Tyr Ile Ser 
    1055                 1060                 1065             


Ser Phe  Thr Thr Asp Phe Leu  Ala Val Leu Val Lys  Pro Thr Gly 
    1070                 1075                 1080             


Ser Leu  Gln Ile Arg Tyr Asn  Leu Gly Gly Thr Arg  Glu Pro Tyr 
    1085                 1090                 1095             


Asn Ile  Asp Val Asp His Arg  Asn Met Ala Asn Gly  Gln Pro His 
    1100                 1105                 1110             


Ser Val  Asn Ile Thr Arg His  Glu Lys Thr Ile Phe  Leu Lys Leu 
    1115                 1120                 1125             


Asp His  Tyr Pro Ser Val Ser  Tyr His Leu Pro Ser  Ser Ser Asp 
    1130                 1135                 1140             


Thr Leu  Phe Asn Ser Pro Lys  Ser Leu Phe Leu Gly  Lys Val Ile 
    1145                 1150                 1155             


Glu Thr  Gly Lys Ile Asp Gln  Glu Ile His Lys Tyr  Asn Thr Pro 
    1160                 1165                 1170             


Gly Phe  Thr Gly Cys Leu Ser  Arg Val Gln Phe Asn  Gln Ile Ala 
    1175                 1180                 1185             


Pro Leu  Lys Ala Ala Leu Arg  Gln Thr Asn Ala Ser  Ala His Val 
    1190                 1195                 1200             


His Ile  Gln Gly Glu Leu Val  Glu Ser Asn Cys Gly  Ala Ser Pro 
    1205                 1210                 1215             


Leu Thr  Leu Ser Pro Met Ser  Ser Ala Thr Asp Pro  Trp His Leu 
    1220                 1225                 1230             


Asp His  Leu Asp Ser Ala Ser  Ala Asp Phe Pro Tyr  Asn Pro Gly 
    1235                 1240                 1245             


Gln Gly  Gln Ala Ile Arg Asn  Gly Val Asn Arg Asn  Ser Ala Ile 
    1250                 1255                 1260             


Ile Gly  Gly Val Ile Ala Val  Val Ile Phe Thr Ile  Leu Cys Thr 
    1265                 1270                 1275             


Leu Val  Phe Leu Ile Arg Tyr  Met Phe Arg His Lys  Gly Thr Tyr 
    1280                 1285                 1290             


His Thr  Asn Glu Ala Lys Gly  Ala Glu Ser Ala Glu  Ser Ala Asp 
    1295                 1300                 1305             


Ala Ala  Ile Met Asn Asn Asp  Pro Asn Phe Thr Glu  Thr Ile Asp 
    1310                 1315                 1320             


Glu Ser  Lys Lys Glu Trp Leu  Ile 
    1325                 1330     


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  3

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr 
            20                  25          


<210>  4
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain

<400>  4

Ala Pro Ser Thr Ser Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu 
1               5                   10                  15      


Pro His Val Ala Phe Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser 
            20                  25                  30          


Pro Gly Tyr Ala Lys Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser 
        35                  40                  45              


Pro Ser Asp Ser Asp His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn 
    50                  55                  60                  


Arg Lys Gln Ile Ser Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser 
65                  70                  75                  80  


Asp Trp Val Thr Gln Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn 
                85                  90                  95      


Trp Lys Pro Tyr His Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn 
            100                 105                 110         


Ile Asn Ser Asp Gly Val Val Arg His Glu Leu Gln His Pro Ile Ile 
        115                 120                 125             


Ala Arg Tyr Val Arg Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg 
    130                 135                 140                 


Ile Gly Leu Arg Ile Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val 
145                 150                 155                 160 


Ile Asn Phe Asp Gly His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys 
                165                 170                 175     


Lys Met Lys Thr Leu Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser 
            180                 185                 190         


Glu Ser Glu Gly Val Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr 
        195                 200                 205             


Ile Thr Leu Glu Leu Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu 
    210                 215                 220                 


Gly Ser Asn Gln Leu Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr 
225                 230                 235                 240 


Gly Ser Leu Leu Asp Asp His His Trp His Ser Val Val Ile Glu Arg 
                245                 250                 255     


Gln Gly Arg Ser Ile Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe 
            260                 265                 270         


Arg Thr Asn Gly Glu Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr 
        275                 280                 285             


Phe Gly Gly Ile Pro Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys 
    290                 295                 300                 


Asn Phe Lys Gly Cys Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile 
305                 310                 315                 320 


Thr Asp Leu Ala Arg Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn 
                325                 330                 335     


Leu Ser Phe Ser Cys Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn 
            340                 345                 350         


Ala Thr Ser Tyr Leu Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe 
        355                 360                 365             


Ser Val Ser Phe Gln Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val 
    370                 375                 380                 


Phe Ser His Phe Ala Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr 
385                 390                 395                 400 


Glu Ser Lys Val Gly Val His Ile Asn Ile Thr Gln Thr Lys Met Ser 
                405                 410                 415     


Gln Ile Asp Ile Ser Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His 
            420                 425                 430         


Glu Val Arg Phe Leu Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp 
        435                 440                 445             


Gly Asp Glu Ala Ser Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys 
    450                 455                 460                 


Thr Gly Glu Lys Tyr Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn 
465                 470                 475                 480 


Ser Ser His Ser Val Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu 
                485                 490                 495     


Ile Gln Val Asp Asp Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg 
            500                 505                 510         


Lys Pro Gly Ser Phe Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile 
        515                 520                 525             


Asp Arg Cys Val Pro Asn His Cys Glu His Gly Gly Lys Cys Ser Gln 
    530                 535                 540                 


Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly 
545                 550                 555                 560 


Ala Thr Cys His Asn Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys 
                565                 570                 575     


His Leu Gly Gln Thr Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser 
            580                 585                 590         


Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys 
        595                 600                 605             


Val Trp Thr Ile Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val 
    610                 615                 620                 


Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala 
625                 630                 635                 640 


Ser Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu 
                645                 650                 655     


Gln Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro 
            660                 665                 670         


Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His 
        675                 680                 685             


Tyr Tyr Trp Gly Gly Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly 
    690                 695                 700                 


Ile Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala 
705                 710                 715                 720 


Asp Tyr Lys Gln Trp Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp 
                725                 730                 735     


His Leu Pro Val Ser Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly 
            740                 745                 750         


Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg 
        755                 760                 765             


Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His 
    770                 775                 780                 


Phe Ser Thr Phe Gln Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe 
785                 790                 795                 800 


Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu 
                805                 810                 815     


Asp Phe Ile Lys Leu Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser 
            820                 825                 830         


Phe Asp Val Gly Asn Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr 
        835                 840                 845             


Pro Leu Asn Asp Asp Gln Trp His Arg Val Thr Ala Glu Arg Asn Val 
    850                 855                 860                 


Lys Gln Ala Ser Leu Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys 
865                 870                 875                 880 


Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe 
                885                 890                 895     


Val Gly Gly Ala Gly Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser 
            900                 905                 910         


Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val 
        915                 920                 925             


Thr Ser Gly Phe Ile Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly 
    930                 935                 940                 


Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr 
945                 950                 955                 960 


Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe Cys Asn Lys 
                965                 970                 975     


Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg Tyr Asn Phe 
            980                 985                 990         


Gln Ala Pro Ala Thr Asn Ala Arg  Asp Ser Ser Ser Arg  Val Asp Asn 
        995                 1000                 1005             


Ala Pro  Asp Gln Gln Asn Ser  His Pro Asp Leu Ala  Gln Glu Glu 
    1010                 1015                 1020             


Ile Arg  Phe Ser Phe Ser Thr  Thr Lys Ala Pro Cys  Ile Leu Leu 
    1025                 1030                 1035             


Tyr Ile  Ser Ser Phe Thr Thr  Asp Phe Leu Ala Val  Leu Val Lys 
    1040                 1045                 1050             


Pro Thr  Gly Ser Leu Gln Ile  Arg Tyr Asn Leu Gly  Gly Thr Arg 
    1055                 1060                 1065             


Glu Pro  Tyr Asn Ile Asp Val  Asp His Arg Asn Met  Ala Asn Gly 
    1070                 1075                 1080             


Gln Pro  His Ser Val Asn Ile  Thr Arg His Glu Lys  Thr Ile Phe 
    1085                 1090                 1095             


Leu Lys  Leu Asp His Tyr Pro  Ser Val Ser Tyr His  Leu Pro Ser 
    1100                 1105                 1110             


Ser Ser  Asp Thr Leu Phe Asn  Ser Pro Lys Ser Leu  Phe Leu Gly 
    1115                 1120                 1125             


Lys Val  Ile Glu Thr Gly Lys  Ile Asp Gln Glu Ile  His Lys Tyr 
    1130                 1135                 1140             


Asn Thr  Pro Gly Phe Thr Gly  Cys Leu Ser Arg Val  Gln Phe Asn 
    1145                 1150                 1155             


Gln Ile  Ala Pro Leu Lys Ala  Ala Leu Arg Gln Thr  Asn Ala Ser 
    1160                 1165                 1170             


Ala His  Val His Ile Gln Gly  Glu Leu Val Glu Ser  Asn Cys Gly 
    1175                 1180                 1185             


Ala Ser  Pro Leu Thr Leu Ser  Pro Met Ser Ser Ala  Thr Asp Pro 
    1190                 1195                 1200             


Trp His  Leu Asp His Leu Asp  Ser Ala Ser Ala Asp  Phe Pro Tyr 
    1205                 1210                 1215             


Asn Pro  Gly Gln Gly Gln Ala  Ile Arg Asn Gly Val  Asn Arg Asn 
    1220                 1225                 1230             


Ser Ala  
    1235 


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane Domain

<400>  5

Ile Ile Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys Thr 
1               5                   10                  15      


Leu Val Phe Leu Ile 
            20      


<210>  6
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic Domain

<400>  6

Arg Tyr Met Phe Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys 
1               5                   10                  15      


Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala Ala Ile Met Asn Asn Asp 
            20                  25                  30          


Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu Ile 
        35                  40                  45              


<210>  7
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5/8 type domain

<400>  7

Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys Ile Asn 
            20                  25                  30          


Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp His Tyr 
        35                  40                  45              


Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser Ala Ile 
    50                  55                  60                  


Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln Tyr Arg 
65                  70                  75                  80  


Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His Gln Asp 
                85                  90                  95      


Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly Val Val 
            100                 105                 110         


Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg Ile Val 
        115                 120                 125             


Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile Glu Val 
    130                 135                 140                 


Tyr Gly Cys 
145         


<210>  8
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Laminin G-like 1

<400>  8

Phe Lys Thr Ser Glu Ser Glu Gly Val Ile Leu His Gly Glu Gly Gln 
1               5                   10                  15      


Gln Gly Asp Tyr Ile Thr Leu Glu Leu Lys Lys Ala Lys Leu Val Leu 
            20                  25                  30          


Ser Leu Asn Leu Gly Ser Asn Gln Leu Gly Pro Ile Tyr Gly His Thr 
        35                  40                  45              


Ser Val Met Thr Gly Ser Leu Leu Asp Asp His His Trp His Ser Val 
    50                  55                  60                  


Val Ile Glu Arg Gln Gly Arg Ser Ile Asn Leu Thr Leu Asp Arg Ser 
65                  70                  75                  80  


Met Gln His Phe Arg Thr Asn Gly Glu Phe Asp Tyr Leu Asp Leu Asp 
                85                  90                  95      


Tyr Glu Ile Thr Phe Gly Gly Ile Pro Phe Ser Gly Lys Pro Ser Ser 
            100                 105                 110         


Ser Ser Arg Lys Asn Phe Lys Gly Cys Met Glu Ser Ile Asn Tyr Asn 
        115                 120                 125             


Gly Val Asn Ile Thr Asp Leu Ala Arg Arg Lys Lys Leu Glu Pro Ser 
    130                 135                 140                 


Asn Val Gly Asn Leu Ser Phe Ser Cys 
145                 150             


<210>  9
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Laminin G-like 2

<400>  9

Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
1               5                   10                  15      


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            20                  25                  30          


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        35                  40                  45              


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    50                  55                  60                  


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
65                  70                  75                  80  


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                85                  90                  95      


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            100                 105                 110         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        115                 120                 125             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    130                 135                 140                 


Ala Asn Val Ser Ile Asp Met Cys 
145                 150         


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGF-like 1

<400>  10

Ile Ile Asp Arg Cys Val Pro Asn His Cys Glu His Gly Gly Lys Cys 
1               5                   10                  15      


Ser Gln Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr Gly Tyr 
            20                  25                  30          


Ser Gly Ala Thr Cys His 
        35              


<210>  11
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibrinogen C-terminal

<400>  11

Asn Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln 
1               5                   10                  15      


Thr Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly 
            20                  25                  30          


Pro Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile 
        35                  40                  45              


Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro 
    50                  55                  60                  


Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln 
65                  70                  75                  80  


Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser 
                85                  90                  95      


Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro 
            100                 105                 110         


Tyr Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly 
        115                 120                 125             


Gly Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn 
    130                 135                 140                 


Cys Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln 
145                 150                 155                 160 


Trp Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val 
                165                 170                 175     


Ser Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys 
            180                 185                 190         


Leu Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp 
        195                 200                 205         


<210>  12
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Laminin G-like 3

<400>  12

Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr 
1               5                   10                  15      


Phe Gln Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu 
            20                  25                  30          


Thr Pro Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile 
        35                  40                  45              


Lys Leu Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val 
    50                  55                  60                  


Gly Asn Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn 
65                  70                  75                  80  


Asp Asp Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala 
                85                  90                  95      


Ser Leu Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr 
            100                 105                 110         


Glu Gly His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly 
        115                 120                 125             


Ala Gly Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met 
    130                 135                 140                 


Asn Gly Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly 
145                 150                 155                 160 


Phe Ile Ser Gly Cys 
                165 


<210>  13
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGF-like 2

<400>  13

Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly 
1               5                   10                  15      


Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser Asn Thr 
            20                  25                  30          


Ala Tyr Asp Gly Thr Phe Cys Asn 
        35                  40  


<210>  14
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Laminin G-like 4

<400>  14

Phe Ser Thr Thr Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser Phe 
1               5                   10                  15      


Thr Thr Asp Phe Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu Gln 
            20                  25                  30          


Ile Arg Tyr Asn Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp Val 
        35                  40                  45              


Asp His Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile Thr 
    50                  55                  60                  


Arg His Glu Lys Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser Val 
65                  70                  75                  80  


Ser Tyr His Leu Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro Lys 
                85                  90                  95      


Ser Leu Phe Leu Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln Glu 
            100                 105                 110         


Ile His Lys Tyr Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg Val 
        115                 120                 125             


Gln Phe Asn Gln Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr Asn 
    130                 135                 140                 


Ala Ser Ala His Val His Ile Gln Gly Glu Leu Val Glu Ser Asn Cys 
145                 150                 155                 160 


<210>  15
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  delta-FibC-Lam4

<400>  15
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaactttaa gacgtctgaa      660

agtgaaggag taatcctgca cggagaagga cagcaaggag attacattac cttggaactg      720

aaaaaagcca agctggtcct cagtttaaac ttaggaagca accagcttgg ccccatatat      780

ggccacacat cagtgatgac aggaagtttg ctggatgacc accactggca ctctgtggtc      840

attgagcgcc aggggcggag cattaacctc actctggaca ggagcatgca gcacttccgt      900

accaatggag agtttgacta cctggacttg gactatgaga taacctttgg aggcatccct      960

ttctctggca agcccagctc cagcagtaga aagaatttca aaggctgcat ggaaagcatc     1020

aactacaatg gcgtcaacat tactgatctt gccagaagga agaaattaga gccctcaaat     1080

gtgggaaatt tgagcttttc ttgtgtggaa ccctatacgg tgcctgtctt tttcaacgct     1140

acaagttacc tggaggtgcc cggacggctt aaccaggacc tgttctcagt cagtttccag     1200

tttaggacat ggaaccccaa tggtctcctg gtcttcagtc actttgcgga taatttgggc     1260

aatgtggaga ttgacctcac tgaaagcaaa gtgggtgttc acatcaacat cacacagacc     1320

aagatgagcc aaatcgatat ttcctcaggt tctgggttga atgatggaca gtggcacgag     1380

gttcgcttcc tagccaagga aaattttgct attctcacca tcgatggaga tgaagcatca     1440

gcagttcgaa ctaatagtcc ccttcaagtt aaaactggcg agaagtactt ttttggaggt     1500

tttctgaacc agatgaataa ctcaagtcac tctgtccttc agccttcatt ccaaggatgc     1560

atgcagctca ttcaagtgga cgatcaactt gtaaatttat acgaagtggc acaaaggaag     1620

ccgggaagtt tcgcgaatgt cagcattgac atgtgtgcga tcatagacag atgtgtgccc     1680

aatcactgtg agcatggtgg aaagtgctcg caaacatggg acagcttcaa atgcacttgt     1740

gatgagacag gatacagtgg ggccacctgc cacgcctcgc cgctgaccct ctcccccatg     1800

tcgtccgcca ccgacccctg gcacctggat cacctggatt cagccagtgc ggattttcca     1860

tataatccag gacaaggcca agctataaga aatggagtca acagaaactc ggctatcatt     1920

ggaggcgtca ttgctgtggt gattttcacc atcctgtgca ccctggtctt cctgatccgg     1980

tacatgttcc gccacaaggg cacctaccat accaacgaag caaagggggc ggagtcggca     2040

gagagcgcgg acgccgccat catgaacaac gaccccaact tcacagagac cattgatgaa     2100

agcaaaaagg aatggctcat ttga                                            2124


<210>  16
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-FibC-Lam4

<400>  16

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Ala 
            580                 585                 590         


Ser Pro Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp Pro Trp His 
        595                 600                 605             


Leu Asp His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr Asn Pro Gly 
    610                 615                 620                 


Gln Gly Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser Ala Ile Ile 
625                 630                 635                 640 


Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys Thr Leu Val 
                645                 650                 655     


Phe Leu Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr His Thr Asn 
            660                 665                 670         


Glu Ala Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala Ala Ile Met 
        675                 680                 685             


Asn Asn Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser Lys Lys Glu 
    690                 695                 700                 


Trp Leu Ile 
705         


<210>  17
<211>  2997
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  delta-Disc-Lam1

<400>  17
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgtgga accctatacg      120

gtgcctgtct ttttcaacgc tacaagttac ctggaggtgc ccggacggct taaccaggac      180

ctgttctcag tcagtttcca gtttaggaca tggaacccca atggtctcct ggtcttcagt      240

cactttgcgg ataatttggg caatgtggag attgacctca ctgaaagcaa agtgggtgtt      300

cacatcaaca tcacacagac caagatgagc caaatcgata tttcctcagg ttctgggttg      360

aatgatggac agtggcacga ggttcgcttc ctagccaagg aaaattttgc tattctcacc      420

atcgatggag atgaagcatc agcagttcga actaatagtc cccttcaagt taaaactggc      480

gagaagtact tttttggagg ttttctgaac cagatgaata actcaagtca ctctgtcctt      540

cagccttcat tccaaggatg catgcagctc attcaagtgg acgatcaact tgtaaattta      600

tacgaagtgg cacaaaggaa gccgggaagt ttcgcgaatg tcagcattga catgtgtgcg      660

atcatagaca gatgtgtgcc caatcactgt gagcatggtg gaaagtgctc gcaaacatgg      720

gacagcttca aatgcacttg tgatgagaca ggatacagtg gggccacctg ccacaactct      780

atctacgagc cttcctgtga agcctacaaa cacctaggac agacatcaaa ttattactgg      840

atagatcctg atggcagcgg acctctgggg cctctgaaag tttactgcaa catgacagag      900

gacaaagtgt ggaccatagt gtctcatgac ttgcagatgc agacgcctgt ggtcggctac      960

aacccagaaa aatactcagt gacacagctc gtttacagcg cctccatgga ccagataagt     1020

gccatcactg acagtgccga gtactgcgag cagtatgtct cctatttctg caagatgtca     1080

agattgttga acaccccaga tggaagccct tacacttggt gggttggcaa agccaacgag     1140

aagcactact actggggagg ctctgggcct ggaatccaga aatgtgcctg cggcatcgaa     1200

cgcaactgca cagatcccaa gtactactgt aactgcgacg cggactacaa gcaatggagg     1260

aaggatgctg gtttcttatc atacaaagat cacctgccag tgagccaagt ggtggttgga     1320

gatactgacc gtcaaggctc agaagccaaa ttgagcgtag gtcctctgcg ctgccaagga     1380

gacaggaatt attggaatgc cgcctctttc ccaaacccat cctcctacct gcacttctct     1440

actttccaag gggaaactag cgctgacatt tctttctact tcaaaacatt aaccccctgg     1500

ggagtgtttc ttgaaaatat gggaaaggaa gatttcatca agctggagct gaagtctgcc     1560

acagaagtgt ccttttcatt tgatgtggga aatgggccag tagagattgt agtgaggtca     1620

ccaacccctc tcaacgatga ccagtggcac cgggtcactg cagagaggaa tgtcaagcag     1680

gccagcctac aggtggaccg gctaccgcag cagatccgca aggccccaac agaaggccac     1740

acccgcctgg agctctacag ccagttattt gtgggtggtg ctgggggcca gcagggcttc     1800

ctgggctgca tccgctcctt gaggatgaat ggggtgacac ttgacctgga ggaaagagca     1860

aaggtcacat ctgggttcat atccggatgc tcgggccatt gcaccagcta tggaacaaac     1920

tgtgaaaatg gaggcaaatg cctagagaga taccacggtt actcctgcga ttgctctaat     1980

actgcatatg atggaacatt ttgcaacaaa gatgttggtg cattttttga agaagggatg     2040

tggctacgat ataactttca ggcaccagca acaaatgcca gagactccag cagcagagta     2100

gacaacgctc ccgaccagca gaactcccac ccggacctgg cacaggagga gatccgcttc     2160

agcttcagca ccaccaaggc gccctgcatt ctcctctaca tcagctcctt caccacagac     2220

ttcttggcag tcctcgtcaa acccactgga agcttacaga ttcgatacaa cctgggtggc     2280

acccgagagc catacaatat tgacgtagac cacaggaaca tggccaatgg acagccccac     2340

agtgtcaaca tcacccgcca cgagaagacc atctttctca agctcgatca ttatccttct     2400

gtgagttacc atctgccaag ttcatccgac accctcttca attctcccaa gtcgctcttt     2460

ctgggaaaag ttatagaaac agggaaaatt gaccaagaga ttcacaaata caacacccca     2520

ggattcactg gttgcctctc cagagtccag ttcaaccaga tcgcccctct caaggccgcc     2580

ttgaggcaga caaacgcctc ggctcacgtc cacatccagg gcgagctggt ggagtccaac     2640

tgcggggcct cgccgctgac cctctccccc atgtcgtccg ccaccgaccc ctggcacctg     2700

gatcacctgg attcagccag tgcggatttt ccatataatc caggacaagg ccaagctata     2760

agaaatggag tcaacagaaa ctcggctatc attggaggcg tcattgctgt ggtgattttc     2820

accatcctgt gcaccctggt cttcctgatc cggtacatgt tccgccacaa gggcacctac     2880

cataccaacg aagcaaaggg ggcggagtcg gcagagagcg cggacgccgc catcatgaac     2940

aacgacccca acttcacaga gaccattgat gaaagcaaaa aggaatggct catttga        2997


<210>  18
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-Disc-Lam1

<400>  18

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr 
        35                  40                  45              


Ser Tyr Leu Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val 
    50                  55                  60                  


Ser Phe Gln Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser 
65                  70                  75                  80  


His Phe Ala Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser 
                85                  90                  95      


Lys Val Gly Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile 
            100                 105                 110         


Asp Ile Ser Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val 
        115                 120                 125             


Arg Phe Leu Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp 
    130                 135                 140                 


Glu Ala Ser Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly 
145                 150                 155                 160 


Glu Lys Tyr Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser 
                165                 170                 175     


His Ser Val Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln 
            180                 185                 190         


Val Asp Asp Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro 
        195                 200                 205             


Gly Ser Phe Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg 
    210                 215                 220                 


Cys Val Pro Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp 
225                 230                 235                 240 


Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr 
                245                 250                 255     


Cys His Asn Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu 
            260                 265                 270         


Gly Gln Thr Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro 
        275                 280                 285             


Leu Gly Pro Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp 
    290                 295                 300                 


Thr Ile Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr 
305                 310                 315                 320 


Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met 
                325                 330                 335     


Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr 
            340                 345                 350         


Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly 
        355                 360                 365             


Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr 
    370                 375                 380                 


Trp Gly Gly Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu 
385                 390                 395                 400 


Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr 
                405                 410                 415     


Lys Gln Trp Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu 
            420                 425                 430         


Pro Val Ser Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu 
        435                 440                 445             


Ala Lys Leu Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr 
    450                 455                 460                 


Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser 
465                 470                 475                 480 


Thr Phe Gln Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr 
                485                 490                 495     


Leu Thr Pro Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe 
            500                 505                 510         


Ile Lys Leu Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp 
        515                 520                 525             


Val Gly Asn Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu 
    530                 535                 540                 


Asn Asp Asp Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln 
545                 550                 555                 560 


Ala Ser Leu Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro 
                565                 570                 575     


Thr Glu Gly His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly 
            580                 585                 590         


Gly Ala Gly Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg 
        595                 600                 605             


Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser 
    610                 615                 620                 


Gly Phe Ile Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn 
625                 630                 635                 640 


Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys 
                645                 650                 655     


Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe Cys Asn Lys Asp Val 
            660                 665                 670         


Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg Tyr Asn Phe Gln Ala 
        675                 680                 685             


Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser Arg Val Asp Asn Ala Pro 
    690                 695                 700                 


Asp Gln Gln Asn Ser His Pro Asp Leu Ala Gln Glu Glu Ile Arg Phe 
705                 710                 715                 720 


Ser Phe Ser Thr Thr Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser 
                725                 730                 735     


Phe Thr Thr Asp Phe Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu 
            740                 745                 750         


Gln Ile Arg Tyr Asn Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp 
        755                 760                 765             


Val Asp His Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile 
    770                 775                 780                 


Thr Arg His Glu Lys Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser 
785                 790                 795                 800 


Val Ser Tyr His Leu Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro 
                805                 810                 815     


Lys Ser Leu Phe Leu Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln 
            820                 825                 830         


Glu Ile His Lys Tyr Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg 
        835                 840                 845             


Val Gln Phe Asn Gln Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr 
    850                 855                 860                 


Asn Ala Ser Ala His Val His Ile Gln Gly Glu Leu Val Glu Ser Asn 
865                 870                 875                 880 


Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp 
                885                 890                 895     


Pro Trp His Leu Asp His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr 
            900                 905                 910         


Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser 
        915                 920                 925             


Ala Ile Ile Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys 
    930                 935                 940                 


Thr Leu Val Phe Leu Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr 
945                 950                 955                 960 


His Thr Asn Glu Ala Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala 
                965                 970                 975     


Ala Ile Met Asn Asn Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser 
            980                 985                 990         


Lys Lys Glu Trp Leu Ile 
        995             


<210>  19
<211>  2442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  delta-Disc-Lam2

<400>  19
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aagcgatcat agacagatgt      120

gtgcccaatc actgtgagca tggtggaaag tgctcgcaaa catgggacag cttcaaatgc      180

acttgtgatg agacaggata cagtggggcc acctgccaca actctatcta cgagccttcc      240

tgtgaagcct acaaacacct aggacagaca tcaaattatt actggataga tcctgatggc      300

agcggacctc tggggcctct gaaagtttac tgcaacatga cagaggacaa agtgtggacc      360

atagtgtctc atgacttgca gatgcagacg cctgtggtcg gctacaaccc agaaaaatac      420

tcagtgacac agctcgttta cagcgcctcc atggaccaga taagtgccat cactgacagt      480

gccgagtact gcgagcagta tgtctcctat ttctgcaaga tgtcaagatt gttgaacacc      540

ccagatggaa gcccttacac ttggtgggtt ggcaaagcca acgagaagca ctactactgg      600

ggaggctctg ggcctggaat ccagaaatgt gcctgcggca tcgaacgcaa ctgcacagat      660

cccaagtact actgtaactg cgacgcggac tacaagcaat ggaggaagga tgctggtttc      720

ttatcataca aagatcacct gccagtgagc caagtggtgg ttggagatac tgaccgtcaa      780

ggctcagaag ccaaattgag cgtaggtcct ctgcgctgcc aaggagacag gaattattgg      840

aatgccgcct ctttcccaaa cccatcctcc tacctgcact tctctacttt ccaaggggaa      900

actagcgctg acatttcttt ctacttcaaa acattaaccc cctggggagt gtttcttgaa      960

aatatgggaa aggaagattt catcaagctg gagctgaagt ctgccacaga agtgtccttt     1020

tcatttgatg tgggaaatgg gccagtagag attgtagtga ggtcaccaac ccctctcaac     1080

gatgaccagt ggcaccgggt cactgcagag aggaatgtca agcaggccag cctacaggtg     1140

gaccggctac cgcagcagat ccgcaaggcc ccaacagaag gccacacccg cctggagctc     1200

tacagccagt tatttgtggg tggtgctggg ggccagcagg gcttcctggg ctgcatccgc     1260

tccttgagga tgaatggggt gacacttgac ctggaggaaa gagcaaaggt cacatctggg     1320

ttcatatccg gatgctcggg ccattgcacc agctatggaa caaactgtga aaatggaggc     1380

aaatgcctag agagatacca cggttactcc tgcgattgct ctaatactgc atatgatgga     1440

acattttgca acaaagatgt tggtgcattt tttgaagaag ggatgtggct acgatataac     1500

tttcaggcac cagcaacaaa tgccagagac tccagcagca gagtagacaa cgctcccgac     1560

cagcagaact cccacccgga cctggcacag gaggagatcc gcttcagctt cagcaccacc     1620

aaggcgccct gcattctcct ctacatcagc tccttcacca cagacttctt ggcagtcctc     1680

gtcaaaccca ctggaagctt acagattcga tacaacctgg gtggcacccg agagccatac     1740

aatattgacg tagaccacag gaacatggcc aatggacagc cccacagtgt caacatcacc     1800

cgccacgaga agaccatctt tctcaagctc gatcattatc cttctgtgag ttaccatctg     1860

ccaagttcat ccgacaccct cttcaattct cccaagtcgc tctttctggg aaaagttata     1920

gaaacaggga aaattgacca agagattcac aaatacaaca ccccaggatt cactggttgc     1980

ctctccagag tccagttcaa ccagatcgcc cctctcaagg ccgccttgag gcagacaaac     2040

gcctcggctc acgtccacat ccagggcgag ctggtggagt ccaactgcgg ggcctcgccg     2100

ctgaccctct cccccatgtc gtccgccacc gacccctggc acctggatca cctggattca     2160

gccagtgcgg attttccata taatccagga caaggccaag ctataagaaa tggagtcaac     2220

agaaactcgg ctatcattgg aggcgtcatt gctgtggtga ttttcaccat cctgtgcacc     2280

ctggtcttcc tgatccggta catgttccgc cacaagggca cctaccatac caacgaagca     2340

aagggggcgg agtcggcaga gagcgcggac gccgccatca tgaacaacga ccccaacttc     2400

acagagacca ttgatgaaag caaaaaggaa tggctcattt ga                        2442


<210>  20
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-Disc-Lam2

<400>  20

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Ala Ile Ile Asp Arg Cys Val Pro Asn His Cys Glu His Gly 
        35                  40                  45              


Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu 
    50                  55                  60                  


Thr Gly Tyr Ser Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Pro Ser 
65                  70                  75                  80  


Cys Glu Ala Tyr Lys His Leu Gly Gln Thr Ser Asn Tyr Tyr Trp Ile 
                85                  90                  95      


Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn 
            100                 105                 110         


Met Thr Glu Asp Lys Val Trp Thr Ile Val Ser His Asp Leu Gln Met 
        115                 120                 125             


Gln Thr Pro Val Val Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln 
    130                 135                 140                 


Leu Val Tyr Ser Ala Ser Met Asp Gln Ile Ser Ala Ile Thr Asp Ser 
145                 150                 155                 160 


Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg 
                165                 170                 175     


Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys 
            180                 185                 190         


Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly Ser Gly Pro Gly Ile Gln 
        195                 200                 205             


Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr 
    210                 215                 220                 


Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp Arg Lys Asp Ala Gly Phe 
225                 230                 235                 240 


Leu Ser Tyr Lys Asp His Leu Pro Val Ser Gln Val Val Val Gly Asp 
                245                 250                 255     


Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg 
            260                 265                 270         


Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro 
        275                 280                 285             


Ser Ser Tyr Leu His Phe Ser Thr Phe Gln Gly Glu Thr Ser Ala Asp 
    290                 295                 300                 


Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu 
305                 310                 315                 320 


Asn Met Gly Lys Glu Asp Phe Ile Lys Leu Glu Leu Lys Ser Ala Thr 
                325                 330                 335     


Glu Val Ser Phe Ser Phe Asp Val Gly Asn Gly Pro Val Glu Ile Val 
            340                 345                 350         


Val Arg Ser Pro Thr Pro Leu Asn Asp Asp Gln Trp His Arg Val Thr 
        355                 360                 365             


Ala Glu Arg Asn Val Lys Gln Ala Ser Leu Gln Val Asp Arg Leu Pro 
    370                 375                 380                 


Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu 
385                 390                 395                 400 


Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly Gly Gln Gln Gly Phe Leu 
                405                 410                 415     


Gly Cys Ile Arg Ser Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu 
            420                 425                 430         


Glu Arg Ala Lys Val Thr Ser Gly Phe Ile Ser Gly Cys Ser Gly His 
        435                 440                 445             


Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu 
    450                 455                 460                 


Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly 
465                 470                 475                 480 


Thr Phe Cys Asn Lys Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp 
                485                 490                 495     


Leu Arg Tyr Asn Phe Gln Ala Pro Ala Thr Asn Ala Arg Asp Ser Ser 
            500                 505                 510         


Ser Arg Val Asp Asn Ala Pro Asp Gln Gln Asn Ser His Pro Asp Leu 
        515                 520                 525             


Ala Gln Glu Glu Ile Arg Phe Ser Phe Ser Thr Thr Lys Ala Pro Cys 
    530                 535                 540                 


Ile Leu Leu Tyr Ile Ser Ser Phe Thr Thr Asp Phe Leu Ala Val Leu 
545                 550                 555                 560 


Val Lys Pro Thr Gly Ser Leu Gln Ile Arg Tyr Asn Leu Gly Gly Thr 
                565                 570                 575     


Arg Glu Pro Tyr Asn Ile Asp Val Asp His Arg Asn Met Ala Asn Gly 
            580                 585                 590         


Gln Pro His Ser Val Asn Ile Thr Arg His Glu Lys Thr Ile Phe Leu 
        595                 600                 605             


Lys Leu Asp His Tyr Pro Ser Val Ser Tyr His Leu Pro Ser Ser Ser 
    610                 615                 620                 


Asp Thr Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu Gly Lys Val Ile 
625                 630                 635                 640 


Glu Thr Gly Lys Ile Asp Gln Glu Ile His Lys Tyr Asn Thr Pro Gly 
                645                 650                 655     


Phe Thr Gly Cys Leu Ser Arg Val Gln Phe Asn Gln Ile Ala Pro Leu 
            660                 665                 670         


Lys Ala Ala Leu Arg Gln Thr Asn Ala Ser Ala His Val His Ile Gln 
        675                 680                 685             


Gly Glu Leu Val Glu Ser Asn Cys Gly Ala Ser Pro Leu Thr Leu Ser 
    690                 695                 700                 


Pro Met Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser 
705                 710                 715                 720 


Ala Ser Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly Gln Ala Ile Arg 
                725                 730                 735     


Asn Gly Val Asn Arg Asn Ser Ala Ile Ile Gly Gly Val Ile Ala Val 
            740                 745                 750         


Val Ile Phe Thr Ile Leu Cys Thr Leu Val Phe Leu Ile Arg Tyr Met 
        755                 760                 765             


Phe Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Ala Glu 
    770                 775                 780                 


Ser Ala Glu Ser Ala Asp Ala Ala Ile Met Asn Asn Asp Pro Asn Phe 
785                 790                 795                 800 


Thr Glu Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu Ile 
                805                 810             


<210>  21
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITR

<400>  21
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  22
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITR

<400>  22
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  23
<211>  658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  23
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg        658


<210>  24
<211>  2127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASPR2-AB

<400>  24
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaactttaa gacgtctgaa      660

agtgaaggag taatcctgca cggagaagga cagcaaggag attacattac cttggaactg      720

aaaaaagcca agctggtcct cagtttaaac ttaggaagca accagcttgg ccccatatat      780

ggccacacat cagtgatgac aggaagtttg ctggatgacc accactggca ctctgtggtc      840

attgagcgcc aggggcggag cattaacctc actctggaca ggagcatgca gcacttccgt      900

accaatggag agtttgacta cctggacttg gactatgaga taacctttgg aggcatccct      960

ttctctggca agcccagctc cagcagtaga aagaatttca aaggctgcat ggaaagcatc     1020

aactacaatg gcgtcaacat tactgatctt gccagaagga agaaattaga gccctcaaat     1080

gtgggaaatt tgagcttttc ttgtgtggaa ccctatacgg tgcctgtctt tttcaacgct     1140

acaagttacc tggaggtgcc cggacggctt aaccaggacc tgttctcagt cagtttccag     1200

tttaggacat ggaaccccaa tggtctcctg gtcttcagtc actttgcgga taatttgggc     1260

aatgtggaga ttgacctcac tgaaagcaaa gtgggtgttc acatcaacat cacacagacc     1320

aagatgagcc aaatcgatat ttcctcaggt tctgggttga atgatggaca gtggcacgag     1380

gttcgcttcc tagccaagga aaattttgct attctcacca tcgatggaga tgaagcatca     1440

gcagttcgaa ctaatagtcc ccttcaagtt aaaactggcg agaagtactt ttttggaggt     1500

tttctgaacc agatgaataa ctcaagtcac tctgtccttc agccttcatt ccaaggatgc     1560

atgcagctca ttcaagtgga cgatcaactt gtaaatttat acgaagtggc acaaaggaag     1620

ccgggaagtt tcgcgaatgt cagcattgac atgtgtgcga tcatagacag atgtgtgccc     1680

aatcactgtg agcatggtgg aaagtgctcg caaacatggg acagcttcaa atgcacttgt     1740

gatgagacag gatacagtgg ggccacctgc cacggggcct cgccgctgac cctctccccc     1800

atgtcgtccg ccaccgaccc ctggcacctg gatcacctgg attcagccag tgcggatttt     1860

ccatataatc caggacaagg ccaagctata agaaatggag tcaacagaaa ctcggctatc     1920

attggaggcg tcattgctgt ggtgattttc accatcctgt gcaccctggt cttcctgatc     1980

cggtacatgt tccgccacaa gggcacctac cataccaacg aagcaaaggg ggcggagtcg     2040

gcagagagcg cggacgccgc catcatgaac aacgacccca acttcacaga gaccattgat     2100

gaaagcaaaa aggaatggct catttga                                         2127


<210>  25
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASPR2-AB

<400>  25

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Gly 
            580                 585                 590         


Ala Ser Pro Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp Pro Trp 
        595                 600                 605             


His Leu Asp His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr Asn Pro 
    610                 615                 620                 


Gly Gln Gly Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser Ala Ile 
625                 630                 635                 640 


Ile Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys Thr Leu 
                645                 650                 655     


Val Phe Leu Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr His Thr 
            660                 665                 670         


Asn Glu Ala Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala Ala Ile 
        675                 680                 685             


Met Asn Asn Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser Lys Lys 
    690                 695                 700                 


Glu Trp Leu Ile 
705             


<210>  26
<211>  3327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASPR2-CD

<400>  26
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaactttaa gacgtctgaa      660

agtgaaggag taatcctgca cggagaagga cagcaaggag attacattac cttggaactg      720

aaaaaagcca agctggtcct cagtttaaac ttaggaagca accagcttgg ccccatatat      780

ggccacacat cagtgatgac aggaagtttg ctggatgacc accactggca ctctgtggtc      840

attgagcgcc aggggcggag cattaacctc actctggaca ggagcatgca gcacttccgt      900

accaatggag agtttgacta cctggacttg gactatgaga taacctttgg aggcatccct      960

ttctctggca agcccagctc cagcagtaga aagaatttca aaggctgcat ggaaagcatc     1020

aactacaatg gcgtcaacat tactgatctt gccagaagga agaaattaga gccctcaaat     1080

gtgggaaatt tgagcttttc ttgtaactct atctacgagc cttcctgtga agcctacaaa     1140

cacctaggac agacatcaaa ttattactgg atagatcctg atggcagcgg acctctgggg     1200

cctctgaaag tttactgcaa catgacagag gacaaagtgt ggaccatagt gtctcatgac     1260

ttgcagatgc agacgcctgt ggtcggctac aacccagaaa aatactcagt gacacagctc     1320

gtttacagcg cctccatgga ccagataagt gccatcactg acagtgccga gtactgcgag     1380

cagtatgtct cctatttctg caagatgtca agattgttga acaccccaga tggaagccct     1440

tacacttggt gggttggcaa agccaacgag aagcactact actggggagg ctctgggcct     1500

ggaatccaga aatgtgcctg cggcatcgaa cgcaactgca cagatcccaa gtactactgt     1560

aactgcgacg cggactacaa gcaatggagg aaggatgctg gtttcttatc atacaaagat     1620

cacctgccag tgagccaagt ggtggttgga gatactgacc gtcaaggctc agaagccaaa     1680

ttgagcgtag gtcctctgcg ctgccaagga gacaggaatt attggaatgc cgcctctttc     1740

ccaaacccat cctcctacct gcacttctct actttccaag gggaaactag cgctgacatt     1800

tctttctact tcaaaacatt aaccccctgg ggagtgtttc ttgaaaatat gggaaaggaa     1860

gatttcatca agctggagct gaagtctgcc acagaagtgt ccttttcatt tgatgtggga     1920

aatgggccag tagagattgt agtgaggtca ccaacccctc tcaacgatga ccagtggcac     1980

cgggtcactg cagagaggaa tgtcaagcag gccagcctac aggtggaccg gctaccgcag     2040

cagatccgca aggccccaac agaaggccac acccgcctgg agctctacag ccagttattt     2100

gtgggtggtg ctgggggcca gcagggcttc ctgggctgca tccgctcctt gaggatgaat     2160

ggggtgacac ttgacctgga ggaaagagca aaggtcacat ctgggttcat atccggatgc     2220

tcgggccatt gcaccagcta tggaacaaac tgtgaaaatg gaggcaaatg cctagagaga     2280

taccacggtt actcctgcga ttgctctaat actgcatatg atggaacatt ttgcaacaaa     2340

gatgttggtg cattttttga agaagggatg tggctacgat ataactttca ggcaccagca     2400

acaaatgcca gagactccag cagcagagta gacaacgctc ccgaccagca gaactcccac     2460

ccggacctgg cacaggagga gatccgcttc agcttcagca ccaccaaggc gccctgcatt     2520

ctcctctaca tcagctcctt caccacagac ttcttggcag tcctcgtcaa acccactgga     2580

agcttacaga ttcgatacaa cctgggtggc acccgagagc catacaatat tgacgtagac     2640

cacaggaaca tggccaatgg acagccccac agtgtcaaca tcacccgcca cgagaagacc     2700

atctttctca agctcgatca ttatccttct gtgagttacc atctgccaag ttcatccgac     2760

accctcttca attctcccaa gtcgctcttt ctgggaaaag ttatagaaac agggaaaatt     2820

gaccaagaga ttcacaaata caacacccca ggattcactg gttgcctctc cagagtccag     2880

ttcaaccaga tcgcccctct caaggccgcc ttgaggcaga caaacgcctc ggctcacgtc     2940

cacatccagg gcgagctggt ggagtccaac tgcggggcct cgccgctgac cctctccccc     3000

atgtcgtccg ccaccgaccc ctggcacctg gatcacctgg attcagccag tgcggatttt     3060

ccatataatc caggacaagg ccaagctata agaaatggag tcaacagaaa ctcggctatc     3120

attggaggcg tcattgctgt ggtgattttc accatcctgt gcaccctggt cttcctgatc     3180

cggtacatgt tccgccacaa gggcacctac cataccaacg aagcaaaggg ggcggagtcg     3240

gcagagagcg cggacgccgc catcatgaac aacgacccca acttcacaga gaccattgat     3300

gaaagcaaaa aggaatggct catttga                                         3327


<210>  27
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASPR2-CD

<400>  27

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Asn Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln 
    370                 375                 380                 


Thr Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly 
385                 390                 395                 400 


Pro Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile 
                405                 410                 415     


Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro 
            420                 425                 430         


Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln 
        435                 440                 445             


Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser 
    450                 455                 460                 


Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro 
465                 470                 475                 480 


Tyr Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly 
                485                 490                 495     


Gly Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn 
            500                 505                 510         


Cys Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln 
        515                 520                 525             


Trp Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val 
    530                 535                 540                 


Ser Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys 
545                 550                 555                 560 


Leu Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn 
                565                 570                 575     


Ala Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe 
            580                 585                 590         


Gln Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr 
        595                 600                 605             


Pro Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys 
    610                 615                 620                 


Leu Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly 
625                 630                 635                 640 


Asn Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp 
                645                 650                 655     


Asp Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser 
            660                 665                 670         


Leu Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu 
        675                 680                 685             


Gly His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala 
    690                 695                 700                 


Gly Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn 
705                 710                 715                 720 


Gly Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe 
                725                 730                 735     


Ile Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu 
            740                 745                 750         


Asn Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys 
        755                 760                 765             


Ser Asn Thr Ala Tyr Asp Gly Thr Phe Cys Asn Lys Asp Val Gly Ala 
    770                 775                 780                 


Phe Phe Glu Glu Gly Met Trp Leu Arg Tyr Asn Phe Gln Ala Pro Ala 
785                 790                 795                 800 


Thr Asn Ala Arg Asp Ser Ser Ser Arg Val Asp Asn Ala Pro Asp Gln 
                805                 810                 815     


Gln Asn Ser His Pro Asp Leu Ala Gln Glu Glu Ile Arg Phe Ser Phe 
            820                 825                 830         


Ser Thr Thr Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser Phe Thr 
        835                 840                 845             


Thr Asp Phe Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu Gln Ile 
    850                 855                 860                 


Arg Tyr Asn Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp Val Asp 
865                 870                 875                 880 


His Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile Thr Arg 
                885                 890                 895     


His Glu Lys Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser Val Ser 
            900                 905                 910         


Tyr His Leu Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro Lys Ser 
        915                 920                 925             


Leu Phe Leu Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln Glu Ile 
    930                 935                 940                 


His Lys Tyr Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg Val Gln 
945                 950                 955                 960 


Phe Asn Gln Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr Asn Ala 
                965                 970                 975     


Ser Ala His Val His Ile Gln Gly Glu Leu Val Glu Ser Asn Cys Gly 
            980                 985                 990         


Ala Ser Pro Leu Thr Leu Ser Pro  Met Ser Ser Ala Thr  Asp Pro Trp 
        995                 1000                 1005             


His Leu  Asp His Leu Asp Ser  Ala Ser Ala Asp Phe  Pro Tyr Asn 
    1010                 1015                 1020             


Pro Gly  Gln Gly Gln Ala Ile  Arg Asn Gly Val Asn  Arg Asn Ser 
    1025                 1030                 1035             


Ala Ile  Ile Gly Gly Val Ile  Ala Val Val Ile Phe  Thr Ile Leu 
    1040                 1045                 1050             


Cys Thr  Leu Val Phe Leu Ile  Arg Tyr Met Phe Arg  His Lys Gly 
    1055                 1060                 1065             


Thr Tyr  His Thr Asn Glu Ala  Lys Gly Ala Glu Ser  Ala Glu Ser 
    1070                 1075                 1080             


Ala Asp  Ala Ala Ile Met Asn  Asn Asp Pro Asn Phe  Thr Glu Thr 
    1085                 1090                 1095             


Ile Asp  Glu Ser Lys Lys Glu  Trp Leu Ile 
    1100                 1105             


<210>  28
<211>  2868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASPR2-EF

<400>  28
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaacaactc tatctacgag      660

ccttcctgtg aagcctacaa acacctagga cagacatcaa attattactg gatagatcct      720

gatggcagcg gacctctggg gcctctgaaa gtttactgca acatgacaga ggacaaagtg      780

tggaccatag tgtctcatga cttgcagatg cagacgcctg tggtcggcta caacccagaa      840

aaatactcag tgacacagct cgtttacagc gcctccatgg accagataag tgccatcact      900

gacagtgccg agtactgcga gcagtatgtc tcctatttct gcaagatgtc aagattgttg      960

aacaccccag atggaagccc ttacacttgg tgggttggca aagccaacga gaagcactac     1020

tactggggag gctctgggcc tggaatccag aaatgtgcct gcggcatcga acgcaactgc     1080

acagatccca agtactactg taactgcgac gcggactaca agcaatggag gaaggatgct     1140

ggtttcttat catacaaaga tcacctgcca gtgagccaag tggtggttgg agatactgac     1200

cgtcaaggct cagaagccaa attgagcgta ggtcctctgc gctgccaagg agacaggaat     1260

tattggaatg ccgcctcttt cccaaaccca tcctcctacc tgcacttctc tactttccaa     1320

ggggaaacta gcgctgacat ttctttctac ttcaaaacat taaccccctg gggagtgttt     1380

cttgaaaata tgggaaagga agatttcatc aagctggagc tgaagtctgc cacagaagtg     1440

tccttttcat ttgatgtggg aaatgggcca gtagagattg tagtgaggtc accaacccct     1500

ctcaacgatg accagtggca ccgggtcact gcagagagga atgtcaagca ggccagccta     1560

caggtggacc ggctaccgca gcagatccgc aaggccccaa cagaaggcca cacccgcctg     1620

gagctctaca gccagttatt tgtgggtggt gctgggggcc agcagggctt cctgggctgc     1680

atccgctcct tgaggatgaa tggggtgaca cttgacctgg aggaaagagc aaaggtcaca     1740

tctgggttca tatccggatg ctcgggccat tgcaccagct atggaacaaa ctgtgaaaat     1800

ggaggcaaat gcctagagag ataccacggt tactcctgcg attgctctaa tactgcatat     1860

gatggaacat tttgcaacaa agatgttggt gcattttttg aagaagggat gtggctacga     1920

tataactttc aggcaccagc aacaaatgcc agagactcca gcagcagagt agacaacgct     1980

cccgaccagc agaactccca cccggacctg gcacaggagg agatccgctt cagcttcagc     2040

accaccaagg cgccctgcat tctcctctac atcagctcct tcaccacaga cttcttggca     2100

gtcctcgtca aacccactgg aagcttacag attcgataca acctgggtgg cacccgagag     2160

ccatacaata ttgacgtaga ccacaggaac atggccaatg gacagcccca cagtgtcaac     2220

atcacccgcc acgagaagac catctttctc aagctcgatc attatccttc tgtgagttac     2280

catctgccaa gttcatccga caccctcttc aattctccca agtcgctctt tctgggaaaa     2340

gttatagaaa cagggaaaat tgaccaagag attcacaaat acaacacccc aggattcact     2400

ggttgcctct ccagagtcca gttcaaccag atcgcccctc tcaaggccgc cttgaggcag     2460

acaaacgcct cggctcacgt ccacatccag ggcgagctgg tggagtccaa ctgcggggcc     2520

tcgccgctga ccctctcccc catgtcgtcc gccaccgacc cctggcacct ggatcacctg     2580

gattcagcca gtgcggattt tccatataat ccaggacaag gccaagctat aagaaatgga     2640

gtcaacagaa actcggctat cattggaggc gtcattgctg tggtgatttt caccatcctg     2700

tgcaccctgg tcttcctgat ccggtacatg ttccgccaca agggcaccta ccataccaac     2760

gaagcaaagg gggcggagtc ggcagagagc gcggacgccg ccatcatgaa caacgacccc     2820

aacttcacag agaccattga tgaaagcaaa aaggaatggc tcatttga                  2868


<210>  29
<211>  955
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASPR2-EF

<400>  29

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Asn Ser Ile Tyr Glu Pro Ser Cys Glu 
    210                 215                 220                 


Ala Tyr Lys His Leu Gly Gln Thr Ser Asn Tyr Tyr Trp Ile Asp Pro 
225                 230                 235                 240 


Asp Gly Ser Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn Met Thr 
                245                 250                 255     


Glu Asp Lys Val Trp Thr Ile Val Ser His Asp Leu Gln Met Gln Thr 
            260                 265                 270         


Pro Val Val Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val 
        275                 280                 285             


Tyr Ser Ala Ser Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu 
    290                 295                 300                 


Tyr Cys Glu Gln Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu 
305                 310                 315                 320 


Asn Thr Pro Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala Asn 
                325                 330                 335     


Glu Lys His Tyr Tyr Trp Gly Gly Ser Gly Pro Gly Ile Gln Lys Cys 
            340                 345                 350         


Ala Cys Gly Ile Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys Asn 
        355                 360                 365             


Cys Asp Ala Asp Tyr Lys Gln Trp Arg Lys Asp Ala Gly Phe Leu Ser 
    370                 375                 380                 


Tyr Lys Asp His Leu Pro Val Ser Gln Val Val Val Gly Asp Thr Asp 
385                 390                 395                 400 


Arg Gln Gly Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg Cys Gln 
                405                 410                 415     


Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser 
            420                 425                 430         


Tyr Leu His Phe Ser Thr Phe Gln Gly Glu Thr Ser Ala Asp Ile Ser 
        435                 440                 445             


Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu Asn Met 
    450                 455                 460                 


Gly Lys Glu Asp Phe Ile Lys Leu Glu Leu Lys Ser Ala Thr Glu Val 
465                 470                 475                 480 


Ser Phe Ser Phe Asp Val Gly Asn Gly Pro Val Glu Ile Val Val Arg 
                485                 490                 495     


Ser Pro Thr Pro Leu Asn Asp Asp Gln Trp His Arg Val Thr Ala Glu 
            500                 505                 510         


Arg Asn Val Lys Gln Ala Ser Leu Gln Val Asp Arg Leu Pro Gln Gln 
        515                 520                 525             


Ile Arg Lys Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu Tyr Ser 
    530                 535                 540                 


Gln Leu Phe Val Gly Gly Ala Gly Gly Gln Gln Gly Phe Leu Gly Cys 
545                 550                 555                 560 


Ile Arg Ser Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg 
                565                 570                 575     


Ala Lys Val Thr Ser Gly Phe Ile Ser Gly Cys Ser Gly His Cys Thr 
            580                 585                 590         


Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr 
        595                 600                 605             


His Gly Tyr Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe 
    610                 615                 620                 


Cys Asn Lys Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg 
625                 630                 635                 640 


Tyr Asn Phe Gln Ala Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser Arg 
                645                 650                 655     


Val Asp Asn Ala Pro Asp Gln Gln Asn Ser His Pro Asp Leu Ala Gln 
            660                 665                 670         


Glu Glu Ile Arg Phe Ser Phe Ser Thr Thr Lys Ala Pro Cys Ile Leu 
        675                 680                 685             


Leu Tyr Ile Ser Ser Phe Thr Thr Asp Phe Leu Ala Val Leu Val Lys 
    690                 695                 700                 


Pro Thr Gly Ser Leu Gln Ile Arg Tyr Asn Leu Gly Gly Thr Arg Glu 
705                 710                 715                 720 


Pro Tyr Asn Ile Asp Val Asp His Arg Asn Met Ala Asn Gly Gln Pro 
                725                 730                 735     


His Ser Val Asn Ile Thr Arg His Glu Lys Thr Ile Phe Leu Lys Leu 
            740                 745                 750         


Asp His Tyr Pro Ser Val Ser Tyr His Leu Pro Ser Ser Ser Asp Thr 
        755                 760                 765             


Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu Gly Lys Val Ile Glu Thr 
    770                 775                 780                 


Gly Lys Ile Asp Gln Glu Ile His Lys Tyr Asn Thr Pro Gly Phe Thr 
785                 790                 795                 800 


Gly Cys Leu Ser Arg Val Gln Phe Asn Gln Ile Ala Pro Leu Lys Ala 
                805                 810                 815     


Ala Leu Arg Gln Thr Asn Ala Ser Ala His Val His Ile Gln Gly Glu 
            820                 825                 830         


Leu Val Glu Ser Asn Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro Met 
        835                 840                 845             


Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser Ala Ser 
    850                 855                 860                 


Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn Gly 
865                 870                 875                 880 


Val Asn Arg Asn Ser Ala Ile Ile Gly Gly Val Ile Ala Val Val Ile 
                885                 890                 895     


Phe Thr Ile Leu Cys Thr Leu Val Phe Leu Ile Arg Tyr Met Phe Arg 
            900                 905                 910         


His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Ala Glu Ser Ala 
        915                 920                 925             


Glu Ser Ala Asp Ala Ala Ile Met Asn Asn Asp Pro Asn Phe Thr Glu 
    930                 935                 940                 


Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu Ile 
945                 950                 955 


<210>  30
<211>  2790
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASPR2-GH

<400>  30
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aatgtgatga gccacttgtc      120

tctggactcc cccatgtggc tttcagcagc tcctcctcca tctctggtag ctattctccc      180

ggctatgcca agataaacaa gagaggaggt gctgggggat ggtctccatc agacagcgac      240

cattatcaat ggcttcaggt tgactttggc aatcggaagc agatcagtgc cattgcaacc      300

caaggaaggt atagcagctc agattgggtg acccaatacc ggatgctcta cagcgacaca      360

gggagaaact ggaaacccta tcatcaagat gggaatatct gggcatttcc cggaaacatt      420

aactctgacg gtgtggtccg gcacgaatta cagcatccga ttattgcccg ctatgtgcgc      480

atagtgcctc tggattggaa tggagaaggt cgcattggac tcagaattga agtttatggc      540

tgttcttact gggctgatgt tatcaacttt gatggccatg ttgtattacc atatagattc      600

agaaacaaga agatgaaaac actgaaagat gtcattgcct tgaactttaa gacgtctgaa      660

agtgaaggag taatcctgca cggagaagga cagcaaggag attacattac cttggaactg      720

aaaaaagcca agctggtcct cagtttaaac ttaggaagca accagcttgg ccccatatat      780

ggccacacat cagtgatgac aggaagtttg ctggatgacc accactggca ctctgtggtc      840

attgagcgcc aggggcggag cattaacctc actctggaca ggagcatgca gcacttccgt      900

accaatggag agtttgacta cctggacttg gactatgaga taacctttgg aggcatccct      960

ttctctggca agcccagctc cagcagtaga aagaatttca aaggctgcat ggaaagcatc     1020

aactacaatg gcgtcaacat tactgatctt gccagaagga agaaattaga gccctcaaat     1080

gtgggaaatt tgagcttttc ttgtgtggtt ggagatactg accgtcaagg ctcagaagcc     1140

aaattgagcg taggtcctct gcgctgccaa ggagacagga attattggaa tgccgcctct     1200

ttcccaaacc catcctccta cctgcacttc tctactttcc aaggggaaac tagcgctgac     1260

atttctttct acttcaaaac attaaccccc tggggagtgt ttcttgaaaa tatgggaaag     1320

gaagatttca tcaagctgga gctgaagtct gccacagaag tgtccttttc atttgatgtg     1380

ggaaatgggc cagtagagat tgtagtgagg tcaccaaccc ctctcaacga tgaccagtgg     1440

caccgggtca ctgcagagag gaatgtcaag caggccagcc tacaggtgga ccggctaccg     1500

cagcagatcc gcaaggcccc aacagaaggc cacacccgcc tggagctcta cagccagtta     1560

tttgtgggtg gtgctggggg ccagcagggc ttcctgggct gcatccgctc cttgaggatg     1620

aatggggtga cacttgacct ggaggaaaga gcaaaggtca catctgggtt catatccgga     1680

tgctcgggcc attgcaccag ctatggaaca aactgtgaaa atggaggcaa atgcctagag     1740

agataccacg gttactcctg cgattgctct aatactgcat atgatggaac attttgcaac     1800

aaagatgttg gtgcattttt tgaagaaggg atgtggctac gatataactt tcaggcacca     1860

gcaacaaatg ccagagactc cagcagcaga gtagacaacg ctcccgacca gcagaactcc     1920

cacccggacc tggcacagga ggagatccgc ttcagcttca gcaccaccaa ggcgccctgc     1980

attctcctct acatcagctc cttcaccaca gacttcttgg cagtcctcgt caaacccact     2040

ggaagcttac agattcgata caacctgggt ggcacccgag agccatacaa tattgacgta     2100

gaccacagga acatggccaa tggacagccc cacagtgtca acatcacccg ccacgagaag     2160

accatctttc tcaagctcga tcattatcct tctgtgagtt accatctgcc aagttcatcc     2220

gacaccctct tcaattctcc caagtcgctc tttctgggaa aagttataga aacagggaaa     2280

attgaccaag agattcacaa atacaacacc ccaggattca ctggttgcct ctccagagtc     2340

cagttcaacc agatcgcccc tctcaaggcc gccttgaggc agacaaacgc ctcggctcac     2400

gtccacatcc agggcgagct ggtggagtcc aactgcgggg cctcgccgct gaccctctcc     2460

cccatgtcgt ccgccaccga cccctggcac ctggatcacc tggattcagc cagtgcggat     2520

tttccatata atccaggaca aggccaagct ataagaaatg gagtcaacag aaactcggct     2580

atcattggag gcgtcattgc tgtggtgatt ttcaccatcc tgtgcaccct ggtcttcctg     2640

atccggtaca tgttccgcca caagggcacc taccatacca acgaagcaaa gggggcggag     2700

tcggcagaga gcgcggacgc cgccatcatg aacaacgacc ccaacttcac agagaccatt     2760

gatgaaagca aaaaggaatg gctcatttga                                      2790


<210>  31
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASPR2-GH

<400>  31

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu Ser Val 
    370                 375                 380                 


Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser 
385                 390                 395                 400 


Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln Gly Glu 
                405                 410                 415     


Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly 
            420                 425                 430         


Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu Glu Leu 
        435                 440                 445             


Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn Gly Pro 
    450                 455                 460                 


Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp Gln Trp 
465                 470                 475                 480 


His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu Gln Val 
                485                 490                 495     


Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly His Thr 
            500                 505                 510         


Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly Gly Gln 
        515                 520                 525             


Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly Val Thr 
    530                 535                 540                 


Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile Ser Gly 
545                 550                 555                 560 


Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly 
                565                 570                 575     


Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser Asn Thr 
            580                 585                 590         


Ala Tyr Asp Gly Thr Phe Cys Asn Lys Asp Val Gly Ala Phe Phe Glu 
        595                 600                 605             


Glu Gly Met Trp Leu Arg Tyr Asn Phe Gln Ala Pro Ala Thr Asn Ala 
    610                 615                 620                 


Arg Asp Ser Ser Ser Arg Val Asp Asn Ala Pro Asp Gln Gln Asn Ser 
625                 630                 635                 640 


His Pro Asp Leu Ala Gln Glu Glu Ile Arg Phe Ser Phe Ser Thr Thr 
                645                 650                 655     


Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser Phe Thr Thr Asp Phe 
            660                 665                 670         


Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu Gln Ile Arg Tyr Asn 
        675                 680                 685             


Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp Val Asp His Arg Asn 
    690                 695                 700                 


Met Ala Asn Gly Gln Pro His Ser Val Asn Ile Thr Arg His Glu Lys 
705                 710                 715                 720 


Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser Val Ser Tyr His Leu 
                725                 730                 735     


Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu 
            740                 745                 750         


Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln Glu Ile His Lys Tyr 
        755                 760                 765             


Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg Val Gln Phe Asn Gln 
    770                 775                 780                 


Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr Asn Ala Ser Ala His 
785                 790                 795                 800 


Val His Ile Gln Gly Glu Leu Val Glu Ser Asn Cys Gly Ala Ser Pro 
                805                 810                 815     


Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp Pro Trp His Leu Asp 
            820                 825                 830         


His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly 
        835                 840                 845             


Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser Ala Ile Ile Gly Gly 
    850                 855                 860                 


Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys Thr Leu Val Phe Leu 
865                 870                 875                 880 


Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala 
                885                 890                 895     


Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala Ala Ile Met Asn Asn 
            900                 905                 910         


Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu 
        915                 920                 925             


Ile 
    


<210>  32
<211>  2439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASPR2-IJ

<400>  32
atgcaggcgg ctccgcgcgc cggctgcggg gcagcgctcc tgctgtggat tgtcagcagc       60

tgcctctgca gagcctggac ggctccctcc acgtcccaaa aaatcataga cagatgtgtg      120

cccaatcact gtgagcatgg tggaaagtgc tcgcaaacat gggacagctt caaatgcact      180

tgtgatgaga caggatacag tggggccacc tgccacaact ctatctacga gccttcctgt      240

gaagcctaca aacacctagg acagacatca aattattact ggatagatcc tgatggcagc      300

ggacctctgg ggcctctgaa agtttactgc aacatgacag aggacaaagt gtggaccata      360

gtgtctcatg acttgcagat gcagacgcct gtggtcggct acaacccaga aaaatactca      420

gtgacacagc tcgtttacag cgcctccatg gaccagataa gtgccatcac tgacagtgcc      480

gagtactgcg agcagtatgt ctcctatttc tgcaagatgt caagattgtt gaacacccca      540

gatggaagcc cttacacttg gtgggttggc aaagccaacg agaagcacta ctactgggga      600

ggctctgggc ctggaatcca gaaatgtgcc tgcggcatcg aacgcaactg cacagatccc      660

aagtactact gtaactgcga cgcggactac aagcaatgga ggaaggatgc tggtttctta      720

tcatacaaag atcacctgcc agtgagccaa gtggtggttg gagatactga ccgtcaaggc      780

tcagaagcca aattgagcgt aggtcctctg cgctgccaag gagacaggaa ttattggaat      840

gccgcctctt tcccaaaccc atcctcctac ctgcacttct ctactttcca aggggaaact      900

agcgctgaca tttctttcta cttcaaaaca ttaaccccct ggggagtgtt tcttgaaaat      960

atgggaaagg aagatttcat caagctggag ctgaagtctg ccacagaagt gtccttttca     1020

tttgatgtgg gaaatgggcc agtagagatt gtagtgaggt caccaacccc tctcaacgat     1080

gaccagtggc accgggtcac tgcagagagg aatgtcaagc aggccagcct acaggtggac     1140

cggctaccgc agcagatccg caaggcccca acagaaggcc acacccgcct ggagctctac     1200

agccagttat ttgtgggtgg tgctgggggc cagcagggct tcctgggctg catccgctcc     1260

ttgaggatga atggggtgac acttgacctg gaggaaagag caaaggtcac atctgggttc     1320

atatccggat gctcgggcca ttgcaccagc tatggaacaa actgtgaaaa tggaggcaaa     1380

tgcctagaga gataccacgg ttactcctgc gattgctcta atactgcata tgatggaaca     1440

ttttgcaaca aagatgttgg tgcatttttt gaagaaggga tgtggctacg atataacttt     1500

caggcaccag caacaaatgc cagagactcc agcagcagag tagacaacgc tcccgaccag     1560

cagaactccc acccggacct ggcacaggag gagatccgct tcagcttcag caccaccaag     1620

gcgccctgca ttctcctcta catcagctcc ttcaccacag acttcttggc agtcctcgtc     1680

aaacccactg gaagcttaca gattcgatac aacctgggtg gcacccgaga gccatacaat     1740

attgacgtag accacaggaa catggccaat ggacagcccc acagtgtcaa catcacccgc     1800

cacgagaaga ccatctttct caagctcgat cattatcctt ctgtgagtta ccatctgcca     1860

agttcatccg acaccctctt caattctccc aagtcgctct ttctgggaaa agttatagaa     1920

acagggaaaa ttgaccaaga gattcacaaa tacaacaccc caggattcac tggttgcctc     1980

tccagagtcc agttcaacca gatcgcccct ctcaaggccg ccttgaggca gacaaacgcc     2040

tcggctcacg tccacatcca gggcgagctg gtggagtcca actgcggggc ctcgccgctg     2100

accctctccc ccatgtcgtc cgccaccgac ccctggcacc tggatcacct ggattcagcc     2160

agtgcggatt ttccatataa tccaggacaa ggccaagcta taagaaatgg agtcaacaga     2220

aactcggcta tcattggagg cgtcattgct gtggtgattt tcaccatcct gtgcaccctg     2280

gtcttcctga tccggtacat gttccgccac aagggcacct accataccaa cgaagcaaag     2340

ggggcggagt cggcagagag cgcggacgcc gccatcatga acaacgaccc caacttcaca     2400

gagaccattg atgaaagcaa aaaggaatgg ctcatttga                            2439


<210>  33
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASPR2-IJ

<400>  33

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Ile Ile Asp Arg Cys Val Pro Asn His Cys Glu His Gly Gly 
        35                  40                  45              


Lys Cys Ser Gln Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr 
    50                  55                  60                  


Gly Tyr Ser Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Pro Ser Cys 
65                  70                  75                  80  


Glu Ala Tyr Lys His Leu Gly Gln Thr Ser Asn Tyr Tyr Trp Ile Asp 
                85                  90                  95      


Pro Asp Gly Ser Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn Met 
            100                 105                 110         


Thr Glu Asp Lys Val Trp Thr Ile Val Ser His Asp Leu Gln Met Gln 
        115                 120                 125             


Thr Pro Val Val Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu 
    130                 135                 140                 


Val Tyr Ser Ala Ser Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala 
145                 150                 155                 160 


Glu Tyr Cys Glu Gln Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu 
                165                 170                 175     


Leu Asn Thr Pro Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala 
            180                 185                 190         


Asn Glu Lys His Tyr Tyr Trp Gly Gly Ser Gly Pro Gly Ile Gln Lys 
        195                 200                 205             


Cys Ala Cys Gly Ile Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys 
    210                 215                 220                 


Asn Cys Asp Ala Asp Tyr Lys Gln Trp Arg Lys Asp Ala Gly Phe Leu 
225                 230                 235                 240 


Ser Tyr Lys Asp His Leu Pro Val Ser Gln Val Val Val Gly Asp Thr 
                245                 250                 255     


Asp Arg Gln Gly Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg Cys 
            260                 265                 270         


Gln Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser 
        275                 280                 285             


Ser Tyr Leu His Phe Ser Thr Phe Gln Gly Glu Thr Ser Ala Asp Ile 
    290                 295                 300                 


Ser Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu Asn 
305                 310                 315                 320 


Met Gly Lys Glu Asp Phe Ile Lys Leu Glu Leu Lys Ser Ala Thr Glu 
                325                 330                 335     


Val Ser Phe Ser Phe Asp Val Gly Asn Gly Pro Val Glu Ile Val Val 
            340                 345                 350         


Arg Ser Pro Thr Pro Leu Asn Asp Asp Gln Trp His Arg Val Thr Ala 
        355                 360                 365             


Glu Arg Asn Val Lys Gln Ala Ser Leu Gln Val Asp Arg Leu Pro Gln 
    370                 375                 380                 


Gln Ile Arg Lys Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu Tyr 
385                 390                 395                 400 


Ser Gln Leu Phe Val Gly Gly Ala Gly Gly Gln Gln Gly Phe Leu Gly 
                405                 410                 415     


Cys Ile Arg Ser Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu Glu 
            420                 425                 430         


Arg Ala Lys Val Thr Ser Gly Phe Ile Ser Gly Cys Ser Gly His Cys 
        435                 440                 445             


Thr Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg 
    450                 455                 460                 


Tyr His Gly Tyr Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr 
465                 470                 475                 480 


Phe Cys Asn Lys Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp Leu 
                485                 490                 495     


Arg Tyr Asn Phe Gln Ala Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser 
            500                 505                 510         


Arg Val Asp Asn Ala Pro Asp Gln Gln Asn Ser His Pro Asp Leu Ala 
        515                 520                 525             


Gln Glu Glu Ile Arg Phe Ser Phe Ser Thr Thr Lys Ala Pro Cys Ile 
    530                 535                 540                 


Leu Leu Tyr Ile Ser Ser Phe Thr Thr Asp Phe Leu Ala Val Leu Val 
545                 550                 555                 560 


Lys Pro Thr Gly Ser Leu Gln Ile Arg Tyr Asn Leu Gly Gly Thr Arg 
                565                 570                 575     


Glu Pro Tyr Asn Ile Asp Val Asp His Arg Asn Met Ala Asn Gly Gln 
            580                 585                 590         


Pro His Ser Val Asn Ile Thr Arg His Glu Lys Thr Ile Phe Leu Lys 
        595                 600                 605             


Leu Asp His Tyr Pro Ser Val Ser Tyr His Leu Pro Ser Ser Ser Asp 
    610                 615                 620                 


Thr Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu Gly Lys Val Ile Glu 
625                 630                 635                 640 


Thr Gly Lys Ile Asp Gln Glu Ile His Lys Tyr Asn Thr Pro Gly Phe 
                645                 650                 655     


Thr Gly Cys Leu Ser Arg Val Gln Phe Asn Gln Ile Ala Pro Leu Lys 
            660                 665                 670         


Ala Ala Leu Arg Gln Thr Asn Ala Ser Ala His Val His Ile Gln Gly 
        675                 680                 685             


Glu Leu Val Glu Ser Asn Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro 
    690                 695                 700                 


Met Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser Ala 
705                 710                 715                 720 


Ser Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn 
                725                 730                 735     


Gly Val Asn Arg Asn Ser Ala Ile Ile Gly Gly Val Ile Ala Val Val 
            740                 745                 750         


Ile Phe Thr Ile Leu Cys Thr Leu Val Phe Leu Ile Arg Tyr Met Phe 
        755                 760                 765             


Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Ala Glu Ser 
    770                 775                 780                 


Ala Glu Ser Ala Asp Ala Ala Ile Met Asn Asn Asp Pro Asn Phe Thr 
785                 790                 795                 800 


Glu Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu Ile 
                805                 810         


<210>  34
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer F1 Universal

<400>  34
ctaccggact cagatctcga gatgcaggcg gctccgcgc                              39


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer F2 Universal

<400>  35
tggcgaccgg tggatcccgg gaaatgagcc attccttttt gc                          42


<210>  36
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dFibC-lam4 R1 (AB)

<400>  36
gcgaggcccc gtggcaggtg gccccactgt atcc                                   34


<210>  37
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dFibC-lam4 F2 (AB)

<400>  37
cacctgccac ggggcctcgc cgctgacc                                          28


<210>  38
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam2-EGF1 R1 (CD)

<400>  38
agatagagtt acaagaaaag ctcaaatttc ccac                                   34


<210>  39
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam2-EGF1 F2 (CD)

<400>  39
cttttcttgt aactctatct acgagccttc c                                      31


<210>  40
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam1-EGF1 R1 (EF)

<400>  40
agatagagtt gttcaaggca atgacatctt tcag                                   34


<210>  41
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam2-EGF1 F2 (EF)

<400>  41
tgccttgaac aactctatct acgagccttc c                                      31


<210>  42
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam2-EGF1 R1 (GH)

<400>  42
ctccaaccac acaagaaaag ctcaaatttc ccac                                   34


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer dlam2-EGF1 F2 (GH)

<400>  43
cttttcttgt gtggttggag atactgaccg                                        30


<210>  44
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Link dDisc-lam2 R1 (IJ)

<400>  44
tgtctatgat tttttgggac gtggagggag c                                      31


<210>  45
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Link dDisc-lam2 F2 (IJ)

<400>  45
gtcccaaaaa atcatagaca gatgtgtgcc c                                      31


