                         SEQUENCE LISTING

<110>  Mab Designs Ltd.
 
<120>  Anti-mesothelin antibodies

<130>  69.15.130333/01

<150>  GB1616699.3
<151>  2016-09-30

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  1
gaggtccagc tgcagcagtc tgggactgtg ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagctttacc aattacagga tgaactgggt aaaacagagg      120

cctggacagg gtctagaatg gattggtggt atttatcctg gaaatagaga tactacctac      180

aaccagaagt tcaaggacaa ggccaaactg actgcagtca catccgccaa cactgcctac      240

atggagctca gcagcctgac gaatgaggac tctgcggtct attactgtac aagaggggta      300

atcgggatct actttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  2
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  2
gacattgtga tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctac tactgtcagc aaaataatga ggctccgctc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Arg Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Val Ile Gly Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  4

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn 
                85                  90                  95      


Asn Glu Ala Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  5

Gly Tyr Ser Phe Thr Asn Tyr Arg 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  6

Ile Tyr Pro Gly Asn Arg Asp Thr 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  7

Thr Arg Gly Val Ile Gly Ile Tyr Phe Asp Tyr 
1               5                   10      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  8

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  9

Ala Ala Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  10

Gln Gln Asn Asn Glu Ala Pro Leu Thr 
1               5                   


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  12

Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  13

Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Lys Leu Thr Ala Val Thr 
1               5                   10                  15      


Ser Ala Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  14

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  15

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser 
            20                  25          


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  16

Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  17

Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  18

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  19
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  19
caggtccagc tgcagcagtc tgggactgtg ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagctttacc aactaccgga tgtactgggt aaaacagagg      120

cctggacagg gtctagaatg gattggtgct atttatcctg gaaatagtga tactacctac      180

aagcagaagt tcaagggcaa ggccaaactg actgcagtca catccgccag cactgcctac      240

atggagctca gcagcctgac aaatgaggac tctgcggtct attactgtac aagggggata      300

cgggggtcgt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctca            354


<210>  20
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  20
cttgacattg tgatgacaca gtctccagct tctttggctg tgtctctagg gcagagggcc       60

accatctcct gcaaggccag ccaaagtgtt gattatgatg gtgatagtta tatgaactgg      120

taccaacaga aaccaggaca gccacccaaa ctcctcatct atgctgcatc caatctagaa      180

tctgggatcc cagccaggtt tagtggcagt gggtctggga cagacttcac cctcaacatc      240

catcctgtgg aggaggagga tgctgcaacc tattactgtc agcaaagtaa tgaggatccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  21
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ile Arg Gly Ser Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  22

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  23

Gly Tyr Ser Phe Thr Asn Tyr Arg 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  24

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  25

Thr Arg Gly Ile Arg Gly Ser Tyr Phe Asp Val 
1               5                   10      


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  26

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  27

Ala Ala Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  28

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  30

Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  31

Thr Tyr Lys Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  32

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  33

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser 
            20                  25          


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  34

Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  35
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  35

Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  36

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa = any amino acid

<400>  37

Ile Tyr Pro Gly Asn Xaa Asp Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa = Arg or Ser

<400>  38

Ile Tyr Pro Gly Asn Xaa Asp Thr 
1               5               


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa = any amino acid

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa = any amino acid

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa = any amino acid

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa = any amino acid

<400>  39

Thr Arg Gly Xaa Xaa Gly Xaa Tyr Phe Asp Xaa 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa = Val or Ile

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa = Ile or Arg

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa = Ile or Ser

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa = Tyr or Val

<400>  40

Thr Arg Gly Xaa Xaa Gly Xaa Tyr Phe Asp Xaa 
1               5                   10      


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa = any amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa = any amino acid

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa = any amino acid

<400>  41

Gln Gln Xaa Asn Glu Xaa Pro Xaa Thr 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa = Asn or Ser

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa = Ala or Asp

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa = Leu or Tyr

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa = Leu or Tyr

<400>  42

Gln Gln Xaa Asn Glu Xaa Pro Xaa Thr 
1               5                   


<210>  43
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  43

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Arg Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Val Ile Gly Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Ala Ala 
    210                 215                 220             


<210>  44
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  44

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn 
                85                  90                  95      


Asn Glu Ala Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
        195                 200                 


<210>  45
<211>  673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  45
gaggtccagc tgcagcagtc tgggactgtg ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagctttacc aattacagga tgaactgggt aaaacagagg      120

cctggacagg gtctagaatg gattggtggt atttatcctg gaaatagaga tactacctac      180

aaccagaagt tcaaggacaa ggccaaactg actgcagtca catccgccaa cactgcctac      240

atggagctca gcagcctgac gaatgaggac tctgcggtct attactgtac aagaggggta      300

atcgggatct actttgacta ctggggccaa ggcaccactc tcacagtctc ctcagccaaa      360

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      420

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      480

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      540

accctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc      600

aacgttgccc acccggccag cagcaccaaa ggtggacaag aaaattgtgc ccagggattg      660

tggtgcggcc gca                                                         673


<210>  46
<211>  664
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  46
gacattgtga tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctac tactgtcagc aaaataatga ggctccgctc      300

acgttcggtg ctgggaccaa gctggagctg aaacgggctg atgctgcacc aactgtatcc      360

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      420

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      480

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      540

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      600

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttaataa      660

ggcg                                                                   664


<210>  47
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  47

Gln Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ile Arg Gly Ser Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Ala Ala 
    210                 215                 220             


<210>  48
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  48

Leu Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  49
<211>  671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  49
caggtccagc tgcagcagtc tgggactgtg ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagctttacc aactaccgga tgtactgggt aaaacagagg      120

cctggacagg gtctagaatg gattggtgct atttatcctg gaaatagtga tactacctac      180

aagcagaagt tcaagggcaa ggccaaactg actgcagtca catccgccag cactgcctac      240

atggagctca gcagcctgac aaatgaggac tctgcggtct attactgtac aagggggata      300

cgggggtcgt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctcagccaaa      360

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      420

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      480

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      540

actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc      600

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt      660

ggtgcggccg c                                                           671


<210>  50
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  50
cttgacattg tgatgacaca gtctccagct tctttggctg tgtctctagg gcagagggcc       60

accatctcct gcaaggccag ccaaagtgtt gattatgatg gtgatagtta tatgaactgg      120

taccaacaga aaccaggaca gccacccaaa ctcctcatct atgctgcatc caatctagaa      180

tctgggatcc cagccaggtt tagtggcagt gggtctggga cagacttcac cctcaacatc      240

catcctgtgg aggaggagga tgctgcaacc tattactgtc agcaaagtaa tgaggatccg      300

tacacgttcg gaggggggac caagctggaa ataaaacggg ctgatgctgc accaactgta      360

tccatcttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc      420

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      480

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg      540

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      600

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgttaa      660

taaggc                                                                 666


<210>  51
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  52
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Pro Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


