               SEQUENCE LISTING

<110> VHsquared Limited

<120> COMPOSITIONS

<130> VHS-P2039PCT

<160> 34

<170> BiSSAP 1.3

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR1 of ID-38F

<400> 1
Ser His Trp Met Tyr 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR2 of ID-38F

<400> 2
Glu Ile Asn Thr Asn Gly Leu Ile Thr His Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR3 of ID-38F

<400> 3
Asn Gln His Gly Leu Asn 
1               5       

<210> 4
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR1 of ID-38F

<400> 4
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30  

<210> 5
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR2 of ID-38F

<400> 5
Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Leu Ser 
1               5                   10                  

<210> 6
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR3 of ID-38F

<400> 6
Arg Phe Thr Val Ser Arg Asn Asn Ala Ala Asn Lys Met Tyr Leu Glu 
1               5                   10                  15      
Leu Thr Arg Leu Glu Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR4 of ID-38F

<400> 7
Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 8
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-38F

<400> 8
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser His 
            20                  25                  30          
Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Leu 
        35                  40                  45              
Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr His Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asn Asn Ala Ala Asn Lys Met Tyr 
65                  70                  75                  80  
Leu Glu Leu Thr Arg Leu Glu Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Gln His Gly Leu Asn Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR1 of ID-142V

<400> 9
Ile Asn Val Met Ala 
1               5   

<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR2 of ID-142V

<400> 10
Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      



<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR3 of ID-142V

<400> 11
Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
1               5                   10          

<210> 12
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR1 of ID-142V

<400> 12
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser 
    

<210> 13
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR2 of ID-142V

<400> 13
Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala 
1               5                   10                  

<210> 14
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR3 of ID-142V

<400> 14
Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala 
            20                  25                  30          



<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR4 of ID-142V

<400> 15
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 16
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V

<400> 16
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 17
<211> 745
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-38F

<400> 17
cgaattggcg gaaggccgtc aaggccacgt gtcttgtcca ggcgcgccag agctcatcac      60

acaaacaaac aaaacaaaat gatgagattt ccttcaattt ttactgccgt tttattcgca     120

gcatcctccg cattagctgc tccagtcaac actacaacag aagatgaaac ggcacaaatt     180

ccggctgaag ctgtcatcgg ttactcagat ttagaagggg atttcgatgt tgctgttttg     240

ccattttcca acagcacaaa taacgggtta ttgtttataa atactactat tgccagcatt     300

gctgctaaag aagaaggggt atctctcgag aaaagagatg ttcaattggt tgaatctggt     360

ggtggtttgg ttcaaccagg tggttctttg aaattgtctt gtgctgcttc tggtttcgat     420

ttctcttctc attggatgta ctgggttaga caagctccag gtaaagaatt ggaatggttg     480

tctgaaatca acaccaacgg tttgattacc cattatggtg attctgtcaa gggtagattc     540

actgtctcta gaaacaatgc tgctaacaag atgtacttgg aattgaccag attggaacca     600

gaagatactg ccttgtatta ctgcgctaga aatcaacatg gtttgaacaa aggtcaaggt     660

actcaagtta ccgtttcctc ataatgactt aagcttatta attaatggag cacaagactg     720

gcctcatggg ccttccgctc actgc                                           745


<210> 18
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-142V

<400> 18
catcatatcg agctcatcac acaaacaaac aaaacaaaat gatgagattt ccttcaattt      60

ttactgccgt tttattcgca gcatcctccg cattagctgc tccagtcaac actacaacag     120

aagatgaaac ggcacaaatt ccggctgaag ctgtcatcgg ttactcagat ttagaagggg     180

atttcgatgt tgctgttttg ccattttcca acagcacaaa taacgggtta ttgtttataa     240

atactactat tgccagcatt gctgctaaag aagaaggggt atctctcgag aaaagagatg     300

tgcagctggt ggagtctggg ggaggtttgg tgcaggctgg ggggtcaacg agactcacct     360

gtaaagcctc tggaagtatc agcaatatca acagtatcaa cgtcatggca tggtaccgcc     420

aggctccagg gaagggtcgc gaattggtcg caattattgg taaaggtggt gggacaaact     480

acgcagactt cgtgaagggc cgattcacca tttccagaga tgctgccaag aacacggtat     540

atctgcaaat gaacagcttg agacctgagg acacggccgt ctattactgt tatgcggatt     600

atgaagatca cgattccccg cataacgctt cctggggcca ggggacccag gtcaccgtct     660

cctcatagta agcttcccat gatg                                            684


<210> 19
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-9K including export signal sequence

<400> 19
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            100                 105                 110         
Phe Asp Phe Ser Ser His Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
        115                 120                 125             
Lys Glu Leu Glu Trp Leu Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr 
    130                 135                 140                 
His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn 
145                 150                 155                 160 
Ala Ala Asn Lys Met Tyr Leu Glu Leu Thr Arg Leu Glu Pro Glu Asp 
                165                 170                 175     
Thr Ala Leu Tyr Tyr Cys Ala Arg Asn Gln His Gly Leu Asn Lys Gly 
            180                 185                 190         
Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Lys Gly 
        195                 200                 205             
Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    210                 215                 220                 
Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile 
225                 230                 235                 240 
Ser Asn Ile Asn Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro 
                245                 250                 255     
Gly Lys Gly Arg Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr 
            260                 265                 270         
Asn Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala 
        275                 280                 285             
Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    290                 295                 300                 
Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro 
305                 310                 315                 320 
His Asn Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                325                 330                 335 

<210> 20
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-10K including export signal sequence

<400> 20
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly 
            100                 105                 110         
Ser Ile Ser Asn Ile Asn Ser Ile Asn Val Met Ala Trp Tyr Arg Gln 
        115                 120                 125             
Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Ile Ile Gly Lys Gly Gly 
    130                 135                 140                 
Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg 
145                 150                 155                 160 
Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                165                 170                 175     
Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp 
            180                 185                 190         
Ser Pro His Asn Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        195                 200                 205             
Ser Gly Gly Gly Gly Ser Lys Gly Gly Gly Gly Ser Asp Val Gln Leu 
    210                 215                 220                 
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
225                 230                 235                 240 
Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser His Trp Met Tyr Trp 
                245                 250                 255     
Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Leu Ser Glu Ile Asn 
            260                 265                 270         
Thr Asn Gly Leu Ile Thr His Tyr Gly Asp Ser Val Lys Gly Arg Phe 
        275                 280                 285             
Thr Val Ser Arg Asn Asn Ala Ala Asn Lys Met Tyr Leu Glu Leu Thr 
    290                 295                 300                 
Arg Leu Glu Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Asn Gln 
305                 310                 315                 320 
His Gly Leu Asn Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                325                 330                 335 

<210> 21
<211> 354
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-11K including export signal sequence

<400> 21
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            100                 105                 110         
Phe Asp Phe Ser Ser His Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
        115                 120                 125             
Lys Glu Leu Glu Trp Leu Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr 
    130                 135                 140                 
His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn 
145                 150                 155                 160 
Ala Ala Asn Lys Met Tyr Leu Glu Leu Thr Arg Leu Glu Pro Glu Asp 
                165                 170                 175     
Thr Ala Leu Tyr Tyr Cys Ala Arg Asn Gln His Gly Leu Asn Lys Gly 
            180                 185                 190         
Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 
Gly Leu Val Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys Lys Ala Ser 
                245                 250                 255     
Gly Ser Ile Ser Asn Ile Asn Ser Ile Asn Val Met Ala Trp Tyr Arg 
            260                 265                 270         
Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Ile Ile Gly Lys Gly 
        275                 280                 285             
Gly Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser 
    290                 295                 300                 
Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp His 
                325                 330                 335     
Asp Ser Pro His Asn Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val 
            340                 345                 350         
Ser Ser 
        

<210> 22
<211> 354
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-12K including export signal sequence

<400> 22
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly 
            100                 105                 110         
Ser Ile Ser Asn Ile Asn Ser Ile Asn Val Met Ala Trp Tyr Arg Gln 
        115                 120                 125             
Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Ile Ile Gly Lys Gly Gly 
    130                 135                 140                 
Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg 
145                 150                 155                 160 
Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                165                 170                 175     
Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp 
            180                 185                 190         
Ser Pro His Asn Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        195                 200                 205             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
225                 230                 235                 240 
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                245                 250                 255     
Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser His Trp 
            260                 265                 270         
Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Leu Ser 
        275                 280                 285             
Glu Ile Asn Thr Asn Gly Leu Ile Thr His Tyr Gly Asp Ser Val Lys 
    290                 295                 300                 
Gly Arg Phe Thr Val Ser Arg Asn Asn Ala Ala Asn Lys Met Tyr Leu 
305                 310                 315                 320 
Glu Leu Thr Arg Leu Glu Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                325                 330                 335     
Arg Asn Gln His Gly Leu Asn Lys Gly Gln Gly Thr Gln Val Thr Val 
            340                 345                 350         
Ser Ser 
        

<210> 23
<211> 334
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-13K including export signal sequence

<400> 23
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            100                 105                 110         
Phe Asp Phe Ser Ser His Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
        115                 120                 125             
Lys Glu Leu Glu Trp Leu Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr 
    130                 135                 140                 
His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn 
145                 150                 155                 160 
Ala Ala Asn Lys Met Tyr Leu Glu Leu Thr Arg Leu Glu Pro Glu Asp 
                165                 170                 175     
Thr Ala Leu Tyr Tyr Cys Ala Arg Asn Gln His Gly Leu Asn Lys Gly 
            180                 185                 190         
Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             
Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    210                 215                 220                 
Ala Gly Gly Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser 
225                 230                 235                 240 
Asn Ile Asn Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly 
                245                 250                 255     
Lys Gly Arg Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn 
            260                 265                 270         
Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala 
        275                 280                 285             
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    290                 295                 300                 
Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His 
305                 310                 315                 320 
Asn Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                325                 330                 

<210> 24
<211> 344
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-14K including export signal sequence

<400> 24
Met Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser 
1               5                   10                  15      
Ser Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala 
            20                  25                  30          
Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp 
        35                  40                  45              
Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu 
    50                  55                  60                  
Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  
Val Ser Leu Glu Lys Arg Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
                85                  90                  95      
Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            100                 105                 110         
Phe Asp Phe Ser Ser His Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
        115                 120                 125             
Lys Glu Leu Glu Trp Leu Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr 
    130                 135                 140                 
His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn 
145                 150                 155                 160 
Ala Ala Asn Lys Met Tyr Leu Glu Leu Thr Arg Leu Glu Pro Glu Asp 
                165                 170                 175     
Thr Ala Leu Tyr Tyr Cys Ala Arg Asn Gln His Gly Leu Asn Lys Gly 
            180                 185                 190         
Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
    210                 215                 220                 
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Thr Arg 
225                 230                 235                 240 
Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn Ser Ile Asn 
                245                 250                 255     
Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
            260                 265                 270         
Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp Phe Val Lys 
        275                 280                 285             
Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu 
    290                 295                 300                 
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
305                 310                 315                 320 
Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser Trp Gly Gln 
                325                 330                 335     
Gly Thr Gln Val Thr Val Ser Ser 
            340                 

<210> 25
<211> 1049
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 19

<400> 25
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaaccag gtggttcttt gaaattgtct tgtgctgctt     360

ctggtttcga tttctcttct cattggatgt actgggttag acaagctcca ggtaaagaat     420

tggaatggtt gtctgaaatc aacaccaacg gtttgattac ccattatggt gattctgtca     480

agggtagatt cactgtctct agaaacaatg ctgctaacaa gatgtacttg gaattgacca     540

gattggaacc agaagatact gccttgtatt actgcgctag aaatcaacat ggtttgaaca     600

aaggtcaagg tactcaagtt actgtttctt caggtggtgg tggtagtaag ggcggtggtg     660

gttcagatgt tcaattagta gaaagtggtg gtggtttagt acaagctggt ggtagtacta     720

gattgacttg taaggcttcc ggttccatct ccaacattaa ctccattaac gttatggcct     780

ggtatagaca agcacctggt aagggtagag aattggttgc tattattggt aaaggtggtg     840

gtacaaacta cgccgatttt gttaagggta gattcaccat ttcaagagat gctgctaaga     900

acaccgttta cttgcaaatg aactccttaa gacctgaaga taccgctgtt tattactgct     960

atgctgatta cgaagatcac gattctccac ataatgcttc atggggtcaa ggtacacagg    1020

tcaccgtttc ctcataatga cttaagctt                                      1049


<210> 26
<211> 1049
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 20

<400> 26
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaagctg gtggttctac tagattgact tgtaaggctt     360

ccggttccat ctccaacatt aactccatta acgttatggc ctggtataga caagctccag     420

gtaaaggtag agaattggtt gctattattg gtaagggtgg tggtactaat tacgccgatt     480

ttgttaaggg tagattcacc atttctagag atgctgctaa gaacaccgtt tacttgcaaa     540

tgaactcctt aagaccagaa gataccgctg tttattactg ctatgctgat tacgaagatc     600

acgattctcc acataatgct tcatggggtc aaggtactca agttactgtt tcttcaggtg     660

gtggtggttc aaagggcggt ggtggtagtg atgtacaatt agtagaaagt ggtggtggtt     720

tagtacaacc aggtggtagt ttgaaattgt cttgtgctgc ttctggtttc gatttctctt     780

ctcattggat gtactgggtt agacaagcac ctggtaaaga attggaatgg ttgtctgaaa     840

tcaacaccaa cggtttgatt acccattatg gtgattctgt caaaggtaga ttcaccgtca     900

gtagaaacaa tgctgccaac aaaatgtact tggaattgac cagattggaa cctgaagata     960

ctgccttgta ttactgcgct agaaatcaac atggtttgaa caaaggtcaa ggtacacagg    1020

tcaccgtttc ctcataatga cttaagctt                                      1049


<210> 27
<211> 1106
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 21

<400> 27
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaaccag gtggttcttt gaaattgtct tgtgctgctt     360

ctggtttcga tttctcttct cattggatgt actgggttag acaagctcca ggtaaagaat     420

tggaatggtt gtctgaaatc aacaccaacg gtttgattac ccattatggt gattctgtca     480

agggtagatt cactgtctct agaaacaatg ctgctaacaa gatgtacttg gaattgacca     540

gattggaacc agaagatact gccttgtatt actgcgctag aaatcaacat ggtttgaaca     600

aaggtcaagg tactcaagtt actgtttctt caggtggagg cggttcaggc ggaggtggct     660

ctggcggtgg cggaagtggt ggcggtggat caggtggtgg cggttcgggc ggtggtggaa     720

gcgatgttca attagtagaa agtggtggtg gtttagtaca agctggtggt agtactagat     780

tgacttgtaa ggcttccggt tccatctcca acattaactc cattaacgtt atggcctggt     840

atagacaagc acctggtaag ggtagagaat tggttgctat tattggtaaa ggtggtggta     900

caaactacgc cgattttgtt aagggtagat tcaccatttc aagagatgct gctaagaaca     960

ccgtttactt gcaaatgaac tccttaagac ctgaagatac cgctgtttat tactgctatg    1020

ctgattacga agatcacgat tctccacata atgcttcatg gggtcaaggt acacaggtca    1080

ccgtttcctc ataatgactt aagctt                                         1106


<210> 28
<211> 1106
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 22

<400> 28
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaagctg gtggttctac tagattgact tgtaaggctt     360

ccggttccat ctccaacatt aactccatta acgttatggc ctggtataga caagctccag     420

gtaaaggtag agaattggtt gctattattg gtaagggtgg tggtactaat tacgccgatt     480

ttgttaaggg tagattcacc atttctagag atgctgctaa gaacaccgtt tacttgcaaa     540

tgaactcctt aagaccagaa gataccgctg tttattactg ctatgctgat tacgaagatc     600

acgattctcc acataatgct tcatggggtc aaggtactca agttactgtt tcttcaggtg     660

gaggcggttc aggcggaggt ggctctggcg gtggcggaag tggtggcggt ggatcaggtg     720

gtggcggttc gggcggtggt ggaagcgatg tacaattagt agaaagtggt ggtggtttag     780

tacaaccagg tggtagtttg aaattgtctt gtgctgcttc tggtttcgat ttctcttctc     840

attggatgta ctgggttaga caagcacctg gtaaagaatt ggaatggttg tctgaaatca     900

acaccaacgg tttgattacc cattatggtg attctgtcaa aggtagattc accgtcagta     960

gaaacaatgc tgccaacaaa atgtacttgg aattgaccag attggaacct gaagatactg    1020

ccttgtatta ctgcgctaga aatcaacatg gtttgaacaa aggtcaaggt acacaggtca    1080

ccgtttcctc ataatgactt aagctt                                         1106


<210> 29
<211> 1046
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 23

<400> 29
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaaccag gtggttcttt gaaattgtct tgtgctgctt     360

ctggtttcga tttctcttct cattggatgt actgggttag acaagctcca ggtaaagaat     420

tggaatggtt gtctgaaatc aacaccaacg gtttgattac ccattatggt gattctgtca     480

agggtagatt cactgtctct agaaacaatg ctgctaacaa gatgtacttg gaattgacca     540

gattggaacc agaagatact gccttgtatt actgcgctag aaatcaacat ggtttgaaca     600

aaggtcaagg tactcaagtt actgtttctt caggtggagg cggttcaggc ggaggtggct     660

ctgatgttca attagtagaa agtggtggtg gtttagtaca agctggtggt agtactagat     720

tgacttgtaa ggcttccggt tccatctcca acattaactc cattaacgtt atggcctggt     780

atagacaagc acctggtaag ggtagagaat tggttgctat tattggtaaa ggtggtggta     840

caaactacgc cgattttgtt aagggtagat tcaccatttc aagagatgct gctaagaaca     900

ccgtttactt gcaaatgaac tccttaagac ctgaagatac cgctgtttat tactgctatg     960

ctgattacga agatcacgat tctccacata atgcttcatg gggtcaaggt acacaggtca    1020

ccgtttcctc ataatgactt aagctt                                         1046


<210> 30
<211> 1076
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding SEQ ID NO: 24

<400> 30
gagctcatca cacaaacaaa caaaacaaaa tgatgagatt tccttcaatt tttactgccg      60

ttttattcgc agcatcctcc gcattagctg ctccagtcaa cactacaaca gaagatgaaa     120

cggcacaaat tccggctgaa gctgtcatcg gttactcaga tttagaaggg gatttcgatg     180

ttgctgtttt gccattttcc aacagcacaa ataacgggtt attgtttata aatactacta     240

ttgccagcat tgctgctaaa gaagaagggg tatctctcga gaaaagagat gttcaattgg     300

ttgaatccgg tggtggtttg gttcaaccag gtggttcttt gaaattgtct tgtgctgctt     360

ctggtttcga tttctcttct cattggatgt actgggttag acaagctcca ggtaaagaat     420

tggaatggtt gtctgaaatc aacaccaacg gtttgattac ccattatggt gattctgtca     480

agggtagatt cactgtctct agaaacaatg ctgctaacaa gatgtacttg gaattgacca     540

gattggaacc agaagatact gccttgtatt actgcgctag aaatcaacat ggtttgaaca     600

aaggtcaagg tactcaagtt actgtttctt caggtggagg cggttcaggc ggaggtggct     660

ctggcggtgg cggaagtggt ggcggtggat cagatgttca attagtagaa agtggtggtg     720

gtttagtaca agctggtggt agtactagat tgacttgtaa ggcttccggt tccatctcca     780

acattaactc cattaacgtt atggcctggt atagacaagc acctggtaag ggtagagaat     840

tggttgctat tattggtaaa ggtggtggta caaactacgc cgattttgtt aagggtagat     900

tcaccatttc aagagatgct gctaagaaca ccgtttactt gcaaatgaac tccttaagac     960

ctgaagatac cgctgtttat tactgctatg ctgattacga agatcacgat tctccacata    1020

atgcttcatg gggtcaaggt acacaggtca ccgtttcctc ataatgactt aagctt        1076


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of enterokinase cleavage site

<400> 31
Asp Asp Asp Asp Lys 
1               5   

<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of specific labile linker used in ID-9K and
      ID-10K

<400> 32
Gly Gly Gly Gly Ser Lys Gly Gly Gly Gly Ser 
1               5                   10      

<210> 33
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of specific non-labile linker used in ID-11K

<400> 33
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  

<210> 34
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-123V

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

