                         SEQUENCE LISTING

<110>  Ascendis Pharma A/S
 
<120>  Controlled-release CNP agonist combination therapy

<130>  CPX70585PC

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (6)..(22)

<400>  1

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  2
<211>  53
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (37)..(53)

<400>  2

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  3
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-53


<220>
<221>  DISULFID
<222>  (38)..(54)

<400>  3

Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  4
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-CNP-53


<220>
<221>  DISULFID
<222>  (38)..(54)

<400>  4

Met Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  5
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-CNP-53


<220>
<221>  DISULFID
<222>  (38)..(54)

<400>  5

Pro Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  6
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-53 M48N


<220>
<221>  DISULFID
<222>  (37)..(53)

<400>  6

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asn 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-53 with deletion of amino acids 15-31


<220>
<221>  DISULFID
<222>  (20)..(36)

<400>  7

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  8
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-52


<220>
<221>  DISULFID
<222>  (36)..(52)

<400>  8

Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
1               5                   10                  15      


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
            20                  25                  30          


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
        35                  40                  45              


Gly Leu Gly Cys 
    50          


<210>  9
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-51


<220>
<221>  DISULFID
<222>  (35)..(51)

<400>  9

Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  10
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-50


<220>
<221>  DISULFID
<222>  (34)..(50)

<400>  10

Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His 
1               5                   10                  15      


Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            20                  25                  30          


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        35                  40                  45              


Gly Cys 
    50  


<210>  11
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-49


<220>
<221>  DISULFID
<222>  (33)..(49)

<400>  11

Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro 
1               5                   10                  15      


Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
            20                  25                  30          


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
        35                  40                  45              


Cys 
    


<210>  12
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-48


<220>
<221>  DISULFID
<222>  (32)..(48)

<400>  12

Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  13
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-47


<220>
<221>  DISULFID
<222>  (31)..(47)

<400>  13

Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
            20                  25                  30          


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45          


<210>  14
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-46


<220>
<221>  DISULFID
<222>  (30)..(46)

<400>  14

Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
1               5                   10                  15      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            20                  25                  30          


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45      


<210>  15
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-45


<220>
<221>  DISULFID
<222>  (29)..(45)

<400>  15

Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  16
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-44


<220>
<221>  DISULFID
<222>  (28)..(44)

<400>  16

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
            20                  25                  30          


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  


<210>  17
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-44 with a deletion of amino acids 14-22


<220>
<221>  DISULFID
<222>  (19)..(35)

<400>  17

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  18
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-44 with a deletion of amino acids 15-22


<220>
<221>  DISULFID
<222>  (20)..(36)

<400>  18

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  19
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-43


<220>
<221>  DISULFID
<222>  (27)..(43)

<400>  19

Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-42


<220>
<221>  DISULFID
<222>  (26)..(42)

<400>  20

Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  21
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-41


<220>
<221>  DISULFID
<222>  (25)..(41)

<400>  21

Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala 
1               5                   10                  15      


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
            20                  25                  30          


Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40      


<210>  22
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-40


<220>
<221>  DISULFID
<222>  (24)..(40)

<400>  22

Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
1               5                   10                  15      


Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
            20                  25                  30          


Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-39


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  23

Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  24
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-38


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  24

Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  25
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-37


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  25

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  26
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-37 mit Q1pQ (pQ = pyroglutamate)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = pyroglutamate

<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  26

Xaa Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  27

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-CNP-37


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  28

Pro Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-CNP-37


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  29

Met Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG-CNP-37


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  30

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  31
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MG-CNP-37


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  31

Met Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  32
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-37 M32N


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  32

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asn 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37 M32N


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  33

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Asn Ser Gly Leu Gly Cys 
        35              


<210>  34
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37 K14Q


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  34

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  35
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37 K14P


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  35

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Pro Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  36
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37 K14Q, deletion of amino acid 15


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  36

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  37
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CNP-37 K14Q, K15Q


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  37

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Gln 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  38
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-36


<220>
<221>  DISULFID
<222>  (20)..(36)

<400>  38

Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  39
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-35


<220>
<221>  DISULFID
<222>  (19)..(35)

<400>  39

His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  40
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-34


<220>
<221>  DISULFID
<222>  (18)..(34)

<400>  40

Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
1               5                   10                  15      


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
            20                  25                  30          


Gly Cys 
        


<210>  41
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-33


<220>
<221>  DISULFID
<222>  (17)..(33)

<400>  41

Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
1               5                   10                  15      


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30          


Cys 
    


<210>  42
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-32


<220>
<221>  DISULFID
<222>  (16)..(32)

<400>  42

Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
1               5                   10                  15      


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30          


<210>  43
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-31


<220>
<221>  DISULFID
<222>  (15)..(31)

<400>  43

Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
1               5                   10                  15      


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30      


<210>  44
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-30


<220>
<221>  DISULFID
<222>  (14)..(30)

<400>  44

Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
1               5                   10                  15      


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-29


<220>
<221>  DISULFID
<222>  (13)..(29)

<400>  45

Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
1               5                   10                  15      


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  


<210>  46
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-28


<220>
<221>  DISULFID
<222>  (12)..(28)

<400>  46

Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  47
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHKSEVAHRF-CNP-28


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  47

Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  48
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  48

Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  49
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4Q, K5Q


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  49

Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  50
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4R, K5R


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  50

Gly Ala Asn Arg Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  51
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4P, K5R


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  51

Gly Ala Asn Pro Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  52
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4S, K5S


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  52

Gly Ala Asn Ser Ser Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  53
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAN-CNP-27 K4P, K5R


<220>
<221>  DISULFID
<222>  (14)..(30)

<400>  53

Gly Ala Asn Gly Ala Asn Pro Arg Gly Leu Ser Arg Gly Cys Phe Gly 
1               5                   10                  15      


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30  


<210>  54
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4R, K5R, K9R


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  54

Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-27 K4R, K5R, K9R, M22N


<220>
<221>  DISULFID
<222>  (11)..(27)

<400>  55

Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Asn Ser Gly Leu Gly Cys 
            20                  25          


<210>  56
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-CNP-27 K4R, K5R, K9R


<220>
<221>  DISULFID
<222>  (12)..(28)

<400>  56

Pro Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  57
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-CNP-27 K4R, K5R, K9R


<220>
<221>  DISULFID
<222>  (12)..(28)

<400>  57

Met Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  58
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Serum Albumine Fragment - CNP-27


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  58

Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  59
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Serum Albumine Fragment - CNP-27 M22N


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  59

Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Asn Ser Gly Leu Gly Cys 
        35              


<210>  60
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  methionine - Human Serum Albumine Fragment - CNP-27


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  60

Met Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  61
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proline - Human Serum Albumine Fragment - CNP-27


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  61

Pro Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-26


<220>
<221>  DISULFID
<222>  (10)..(26)

<400>  62

Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25      


<210>  63
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-25


<220>
<221>  DISULFID
<222>  (9)..(25)

<400>  63

Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
1               5                   10                  15      


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25  


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-24


<220>
<221>  DISULFID
<222>  (8)..(24)

<400>  64

Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  65
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-23


<220>
<221>  DISULFID
<222>  (7)..(23)

<400>  65

Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  66
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R-CNP-22


<220>
<221>  DISULFID
<222>  (7)..(23)

<400>  66

Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER-CNP-22


<220>
<221>  DISULFID
<222>  (8)..(24)

<400>  67

Glu Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R-CNP-22 K4R


<220>
<221>  DISULFID
<222>  (7)..(23)

<400>  68

Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER-CNP-22 4KR


<220>
<221>  DISULFID
<222>  (8)..(24)

<400>  69

Glu Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  70
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RR-CNP-22


<220>
<221>  DISULFID
<222>  (8)..(24)

<400>  70

Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  71
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRGP fragment - CNP-22


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  71

Gly His His Ser His Glu Gln His Pro His Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  72
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRGP fragment - CNP-22


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  72

Gly Ala His His Pro His Glu His Asp Thr His Gly Ala Asn Gln Gln 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  73
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRGP fragment - CNP-22


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  73

Gly His His Ser His Glu Gln His Pro His Gly Ala Asn Pro Arg Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  74
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1(FC) fragment - CNP-22


<220>
<221>  DISULFID
<222>  (20)..(36)

<400>  74

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  75
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Serum Albumine - CNP-22


<220>
<221>  DISULFID
<222>  (23)..(39)

<400>  75

Gly Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Gly Ala Asn Pro 
1               5                   10                  15      


Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  76
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Serum Albumine - CNP-22


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  76

Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  77
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  osteocrin NPR C inhibitor fragment - CNP-22


<220>
<221>  DISULFID
<222>  (19)..(35)

<400>  77

Phe Gly Ile Pro Met Asp Arg Ile Gly Arg Asn Pro Arg Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  78
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2 heparin-binding domain fragment - CNP-22


<220>
<221>  DISULFID
<222>  (24)..(40)

<400>  78

Gly Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly 
1               5                   10                  15      


Pro Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
            20                  25                  30          


Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40  


<210>  79
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1(FC) fragment - CNP-22 K4R


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  79

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  80
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Serum Albumine fragment - CNP-22 K4R


<220>
<221>  DISULFID
<222>  (20)..(36)

<400>  80

Gly Val Pro Gln Val Ser Thr Ser Thr Gly Ala Asn Gln Gln Gly Leu 
1               5                   10                  15      


Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  81
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibronectin fragment - CNP-22


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  81

Gly Gln Pro Ser Ser Ser Ser Gln Ser Thr Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  82
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibronectin fragment - CNP-22 K4R


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  82

Gly Gln Thr His Ser Ser Gly Thr Gln Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  83
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibronectin fragment - CNP-22 K4R


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  83

Gly Ser Thr Gly Gln Trp His Ser Glu Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  84
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  zinc finger fragment - CNP-22 K4R


<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  84

Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  85
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-21


<220>
<221>  DISULFID
<222>  (5)..(21)

<400>  85

Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
1               5                   10                  15      


Ser Gly Leu Gly Cys 
            20      


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-20


<220>
<221>  DISULFID
<222>  (4)..(20)

<400>  86

Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
1               5                   10                  15      


Gly Leu Gly Cys 
            20  


<210>  87
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-19


<220>
<221>  DISULFID
<222>  (3)..(19)

<400>  87

Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
1               5                   10                  15      


Leu Gly Cys 
            


<210>  88
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-18


<220>
<221>  DISULFID
<222>  (2)..(18)

<400>  88

Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-17


<220>
<221>  DISULFID
<222>  (1)..(17)

<400>  89

Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
1               5                   10                  15      


Cys 
    


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNP fragment - CNP-17 - BNP- fragment


<220>
<221>  DISULFID
<222>  (10)..(26)

<400>  90

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Leu Lys Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  91
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-38 L1G


<220>
<221>  DISULFID
<222>  (22)..(38)

<400>  91

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  92
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-CNP-37


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  92

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  93
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-37, Xaa = K or R, with the provision that at least one Xaa is
       R


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<220>
<221>  DISULFID
<222>  (21)..(37)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = Lys, Arg, Pro, Ser or Gln, with the provision that at least
       one of amino acids 8, 10, 14, 15, 19 or 25 is selected from the 
       group consisting of Arg, Pro, Ser and Gln

<400>  93

Gln Glu His Pro Asn Ala Arg Xaa Tyr Xaa Gly Ala Asn Xaa Xaa Gly 
1               5                   10                  15      


Leu Ser Xaa Gly Cys Phe Gly Leu Xaa Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  94
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CNP-37


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is selected from the group consising of Lys, Arg, Pro, Ser and 
       Gln, with the provision that at least one of the amino acids at 
       position 14, 15, 19 and 25 is selected from the group consisting 
       of  Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is selected from the group consising of Lys, Arg, Pro, Ser and 
       Gln, with the provision that at least one of the amino acids at 
       position 14, 15, 19 and 25 is selected from the group consisting 
       of  Arg, Pro, Ser and Gln

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is selected from the group consising of Lys, Arg, Pro, Ser and 
       Gln, with the provision that at least one of the amino acids at 
       position 14, 15, 19 and 25 is selected from the group consisting 
       of  Arg, Pro, Ser and Gln

<220>
<221>  DISULFID
<222>  (21)..(37)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is selected from the group consising of Lys, Arg, Pro, Ser and 
       Gln, with the provision that at least one of the amino acids at 
       position 14, 15, 19 and 25 is selected from the group consisting 
       of  Arg, Pro, Ser and Gln

<400>  94

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Xaa Xaa Gly 
1               5                   10                  15      


Leu Ser Xaa Gly Cys Phe Gly Leu Xaa Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  95
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated CNP-37


<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  Xaa Xaa is selected from the group consisting of Lys Arg, Arg 
       Lys, Lys Pro, Pro Lys, Ser Ser, Arg Ser, Ser Arg, Gln Lys, Gln 
       Arg, Lys Gln, Arg Gln, Arg Arg and Gln Gln

<220>
<221>  DISULFID
<222>  (21)..(37)

<400>  95

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Xaa Xaa Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
1               5                   10                  15  


<210>  97
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial random coil

<400>  97

Gly Gly Pro Gly Gly Pro Gly Pro Gly Gly Pro Gly Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gly Pro Gly 
            20  


<210>  98
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPR-C inhibitor

<400>  98

Phe Gly Ile Pro Met Asp Arg Ile Gly Arg Asn Pro Arg 
1               5                   10              


<210>  99
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  99

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


