                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Improved method for selecting polypeptide producing cells

<130>  P33876-WO

<150>  EP16191586.3
<151>  2016-09-26

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-B intron 6-exon M1M2 junction

<400>  1
cagcactgac cacccccttc ctgtccagag ctg                                    33


<210>  2
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-mut-bp intron 6-exon M1M2 junction

<400>  2
cagcacctac cacccccttc ctgtccagag ctg                                    33


<210>  3
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-mut-p(Y) intron 6-exon M1M2 junction

<400>  3
cagcactgac cacgccaatc gtgtccagag ctg                                    33


<210>  4
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-mut-bp-p(Y) intron 6-exon M1M2 junction

<400>  4
cagcacctac cacgccaatc gtgtccagag ctg                                    33


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'-splice site consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  5
nnytvayyyy yyyyyyyyny aggt                                              24


<210>  6
<211>  4608
<212>  DNA
<213>  Homo sapiens

<400>  6
cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg       60

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      120

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      180

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      240

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttggtgaga      300

ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc tgcctggacg      360

catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg cctcttcacc      420

cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct ttttccccgg      480

ctctgggcag gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg      540

ctgggctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac      600

cccaaaggcc aaactctcca ctccctcagc tcggacacct tctctcctcc cagattccag      660

taactcccaa tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac      720

cgtgcccagg taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta      780

gagtagcctg catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct      840

tcctcagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg     1200

ccacatggac agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac     1260

ctctgtccct acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     1320

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga     1380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     1440

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag     1500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     1560

cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgg caagcccccg     1620

ctccccgggc tctcgcggtc gcacgaggat gcttggcacg taccccctgt acatacttcc     1680

cgggcgccca gcatggaaat aaagcaccca gcgctgccct gggcccctgc gagactgtga     1740

tggttctttc cacgggtcag gccgagtctg aggcctgagt ggcatgaggg aggcagagcg     1800

ggtcccactg tccccacact ggcccaggct gtgcaggtgt gcctgggccg cctagggtgg     1860

ggctcagcca ggggctgccc tcggcagggt gggggatttg ccagcgtggc cctccctcca     1920

gcagcacctg ccctgggctg ggccacggga agccctagga gcccctgggg acagacacac     1980

agcccctgcc tctgtaggag actgtcctgt tctgtgagcg ccctgtcctc cgacctccat     2040

gcccactcgg gggcatgcct agtccatgcg cgtagggaca ggccctccct cacccatcta     2100

cccccacggc actaacccct ggcagccctg cccagcctcg cacccacatg gggacacaac     2160

cgactcctgg ggacatgcac tctcgggccc tgtggaggga ctggtccaga tgcccacaca     2220

cacactcagc ccagacccgt tcaacaaacc ccgcactgag gttggccggc cacacggcca     2280

ccacacacac acgtgcacgc ctcacacacg gagcttcacc cgggcgaacc gcacagcacc     2340

cagaccagag caaggtcctc gcacacgtga acactcctcg gacacaggcc cccacgagcc     2400

ccacgcggca cctcaaggcc cacgagccgc tcggcagctt ctccacttgc tgaccagctc     2460

agacaaaccc agccctcctc tcacaaagtg cccctgcagc cgccacacac acacaggccc     2520

ccacacacag gggaacacac gccacgtcac gtccctggca ctggcccact tcccaataca     2580

gcccttccct gcagctgagg tcacatgagg tgtgggcttc accatcctcc tgccctctgg     2640

gcctcaggga gggacacggg agacggggag tgggtcctgc tgagggccag gcctctatct     2700

agggccgggt gtctggctga gtcccggggc caaagctggt gcccagggcg ggcagctgtg     2760

gggagctgac ctcaggacac tgttggccca tcccggccgg gccctacatc ctgggccccg     2820

ccacagaggg aatcaccccc agaggcccaa gcccaggggg acacagcact gaccaccccc     2880

ttcctgtcca gagctgcaac tggaggagag ctgtgcggag gcgcaggacg gggagctgga     2940

cgggctgtgg acgaccatca ccatcttcat cacactcttc ctgctaagcg tgtgctacag     3000

tgccaccgtc accttcttca aggtgaagtg gatcttctcc tcggtggtgg acctgaagca     3060

gaccatcgtc cccgactaca ggaacatgat aaggcagggg gcctagggcc accctctgcg     3120

gggtgtccag ggccgcccag accccacaca cgagccgtgg gccatgctca gccaccaccc     3180

aggccacacc tgccccctga cctcaccgcc ctcaacccca tggctctctg gcttcgcagt     3240

cgccctctga gccctgaaac gccccccttc cagaccctgt gcatagcagg tctaccccag     3300

acctccgctg cttggtgcca gggcactggg ggccaggtgt cccctcagca ggacgtccct     3360

gccctctgga ccaccaggtg ctcacacaaa aggaggtaac cggcatccca ggcccccact     3420

caggcaggac ctcgccctgg agccaacccc gtccacgcca gcctcctgaa cacaggcatg     3480

gtttccagat ggtgagtggg agcatcagtc gccaaggtag ggaagccaca gcaccatcag     3540

gccctgttgg ggaggcttcc gagagctgcg aaggctcact cagacggcct tcctcccagc     3600

ccgcagccag ccagcctcca ttccgggcac tcccgtgaac tcctgacatg aggaatgagg     3660

ttgttctgat ttcaagcaaa gaacgctgct ctctggctcc tgagaacagt ctcggtgcca     3720

gcaccacccc ttggctgcct gcccacactg ctggattctc gggtggaact cgacccgcag     3780

ggacagccag ccccagagtc cgcactgggg agagaagggg ccaggcccag gacactgcca     3840

cctcccaccc actccagtcc accgagatca ctcagagaag agcctgggcc atgtggccgc     3900

tgcaggagcc ccacagtgca agggtgagga tagcccaagg aagggctggg catctgccca     3960

gacaggcctc ccacagaagg ctggtgacca ggtcccaggc gggcaagact cagccttggt     4020

ggggcctgag gacagaggag gcccaggagc atcggggaga gaggtggagg gacaccggga     4080

gagccaggag cgtggacaca gccagaactc accacagagg ctggcgtcca gtcccgggtc     4140

acgtgcagca ggaacaagca gccactctgg gggcaccagg tggagaggca agacgacaaa     4200

gagggtgccc gtgttcttgc gaaagcgggg ctgctggcca cgagtgctgg acagaggccc     4260

ccacgctctg ctgcccccat cacgccgttc cgtgactgtc acgcagaatc cacagacagg     4320

aagggaggct cgagcgggac tgcggccagc gcctgcctcg gccgtcaggg aggactcctg     4380

ggctcactcg aaggaggtgt caccatttca gctttggctt ttcttcttct tttaaatttt     4440

ctaaagctca ttaattgtct ttgatgtttc ttttttgatg acaataaaat atccttttta     4500

agtcttgtac ttcgtgatgg gagccacctt cctgtgtcca cgcgcctcct gcccccggtg     4560

gaaaacacgg tcaggaggag gctggtccag ctgcacctcg ggggatcc                  4608


<210>  7
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of the short (sIgG) isoform of the 
       gamma-chain constant region encoded by plasmid pmIgGdelta-A

<400>  7

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  8
<211>  399
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of the long (mIgG) isoform of the gamma-chain
       constant region encoded by plasmid pmIgGdelta-A

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys 
                325                 330                 335     


Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
            340                 345                 350         


Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val 
        355                 360                 365             


Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys 
    370                 375                 380                 


Gln Thr Ile Val Pro Asp Tyr Arg Asn Met Ile Arg Gln Gly Ala 
385                 390                 395                 


<210>  9
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-B intron 6-excon M1M2 for ESEfinder

<400>  9
ctgtccagag ctgcaactgg aggagagctg tgcggaggcg caggacgggg                  50


<210>  10
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmIgGD-mut-ESE

<400>  10
ctgtccagaa ttgcaattgg aagagagctg tgctgaagct caagatgggg                  50


<210>  11
<211>  1287
<212>  DNA
<213>  Homo sapiens

<400>  11
gtaaatgagt gccacggccg gcaagccccc gctccccagg ctctcggggt cgcgcgagga       60

tgcttggcac gtaccccgtg tacatacttc ccaggcaccc agcatggaaa taaagcaccc      120

agcgcttccc tgggcccctg cgagactgtg atggttcttt ccacgggtca ggccgagtct      180

gaggcctgag tggcatgagg gaggcagagt gggtcccact gtccccacac tggcccaggc      240

tgtgcaggtg tgcctgggcc gcctagggtg gggctcagcc aggggctgcc ctcggcaggg      300

tgggggattt gccagcgtgg ccctccctcc agcagcagct gccctgggct gggccacgag      360

aagccctagg agcccctggg gacagacaca cagcccctgc ctctgtagga gactgtcctg      420

ttctgtgagc gccctgtcct ccgacccgca tgcccactcg ggggcatgcc tagtccatgt      480

gcgtagggac aggccctccc tcacccatct acccccacgg cactaacccc tggcagccct      540

gcccagcctc gcacccgcat ggggacacaa ccgactccgg ggacatgcac tctcgggccc      600

tgtggagaga ctggtccaga tgcccacaca cacactcagc ccagacccgt tcaacaaacc      660

ccgcactgag gttggccggc cacacggcca ccacacacac acgtgcacgc ctcacacacg      720

gagcctcacc cgggcgaacc gcacagcacc cagaccagag caaggtcctc gcacacgtga      780

acactcctcg gacacaggcc cccacgagcc ccacgcggca cctcaaggcc cacgagccgc      840

tcggcagctt ctccacatgc tgacctgctc agacaaaccc agccctcctc tcacaaggtg      900

cccctgcagc cgccacacac acacagggga tcacacacca cgtcacgtcc ctggccctgg      960

cccacttccc agtgccgccc ttccctgcag ctggggtcac atgaggtgtg ggcttcacca     1020

tcctcctgcc ctctgggcct cagggaggga cacgggagac ggggagcggg tcctgctgag     1080

ggccaggtcg ctatctaggg ccgggtgtct ggctgagccc cggggccaaa gctggtgccc     1140

agggcgggca gctgtgggga gctgacctca ggacattgtt ggcccatccc ggccgggccc     1200

tacatcctgg gtcctgccac agagggaatc acccccagag gcccaagccc agggggacac     1260

agcactgacc acgccaatcg tgtccag                                         1287


<210>  12
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  12
gggctgtgga cgaccatcac catcttcatc acactcttcc tgttaagcgt gtgctacagt       60

gccaccgtca ccttcttc                                                     78


<210>  13
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  13
agctgcaact ggaggagagc tgtgcggag                                         29


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-fragment of intron 6 of an immunoglobulin heavy chain 
       structural gene

<400>  14
tgaccacgcc aatcgtgtcc ag                                                22


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid at the junction of intron 6 and exon M1 of an 
       immunoglobulin heavy chain structural gene

<400>  15
tgaccacgcc aatcgtgtcc agagctg                                           27


<210>  16
<211>  2074
<212>  DNA
<213>  Homo sapiens

<400>  16
cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg       60

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      120

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      180

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      240

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttggtgaga      300

ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc tgcctggacg      360

catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg cctcttcacc      420

cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct ttttccccgg      480

ctctgggcag gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg      540

ctgggctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac      600

cccaaaggcc aaactctcca ctccctcagc tcggacacct tctctcctcc cagattccag      660

taactcccaa tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac      720

cgtgcccagg taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta      780

gagtagcctg catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct      840

tcctcagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg     1200

ccacatggac agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac     1260

ctctgtccct acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     1320

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga     1380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     1440

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag     1500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     1560

cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgg caagcccccg     1620

ctccccgggc tctcgcggtc gcacgaggat gcttggcacg taccccctgt acatacttcc     1680

cgggcgccca gcatggaaat aaagcaccca gcgctgccct gggcccctgc gagactgtga     1740

tggttctttc cacgggtcag gccgagtctg aggcctgagt ggcatgaggg aggcagagcg     1800

ggtcccactg tccccacact ggcccaggct gtgcaggtgt gcctgggccg cctagggtgg     1860

ggctcagcca ggggctgccc tcggcagggt gggggatttg ccagcgtggc cctccctcca     1920

gcagcacctg ccctgggctg ggccacggga agccctagga gcccctgggg acagacacac     1980

agcccctgcc tctgtaggag actgtcctgt tctgtgagcg ccctgtcctc cgacctccat     2040

gcccactcgg gggcatgcga cagattgagg atcc                                 2074


<210>  17
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of the gamma-chain constant region encoded by
       plasmid pIgG-A

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  TM-fw1

<400>  18
ggccgagtct gaggcctgag tggcatgagg gaggcagagt                             40


<210>  19
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  TM-rv1

<400>  19
aactggatcc atgtagaaaa gaggagaagc cccgggggtc catgtagt                    48


<210>  20
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  M1-rv

<400>  20
gatccacttc accttgaaga aggtgacggt ggcactgtag cacacgc                     47


<210>  21
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  M2-fw

<400>  21
caccttcttc aaggtgaagt ggatcttctc ctcggtggtg gacctgaag                   49


<210>  22
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  TM-fw2

<400>  22
ctccagcagc agctgccctg ggctgggcca cga                                    33


<210>  23
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  TM-rv2

<400>  23
cagggatccc ccgaggtgca gctggaccag cctcctcctg accgtgtttt                  50


<210>  24
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  mutSphI-1

<400>  24
ctaccccaga cctccgctgc ttggtgcctg cagggcactg ggggccaggt gtcccctcag       60

caggacgt                                                                68


<210>  25
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  mutSphI-2

<400>  25
cctgctgagg ggacacctgg cccccagtgc cctgcaggca ccaagcagcg gaggtctggg       60

gt                                                                      62


<210>  26
<211>  6949
<212>  DNA
<213>  Homo sapiens

<400>  26
cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg       60

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt      120

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag      180

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct      240

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttggtgaga      300

ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc tgcctggacg      360

catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg cctcttcacc      420

cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct ttttccccgg      480

ctctgggcag gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg      540

ctgggctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac      600

cccaaaggcc aaactctcca ctccctcagc tcggacacct tctctcctcc cagattccag      660

taactcccaa tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac      720

cgtgcccagg taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta      780

gagtagcctg catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct      840

tcctcagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg     1200

ccacatggac agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac     1260

ctctgtccct acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     1320

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga     1380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     1440

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag     1500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     1560

cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgg caagcccccg     1620

ctccccgggc tctcgcggtc gcacgaggat gcttggcacg taccccctgt acatacttcc     1680

cgggcgccca gcatggaaat aaagcaccca gcgctgccct gggcccctgc gagactgtga     1740

tggttctttc cacgggtcag gccgagtctg aggcctgagt ggcatgaggg aggcagagcg     1800

ggtcccactg tccccacact ggcccaggct gtgcaggtgt gcctgggccg cctagggtgg     1860

ggctcagcca ggggctgccc tcggcagggt gggggatttg ccagcgtggc cctccctcca     1920

gcagcacctg ccctgggctg ggccacggga agccctagga gcccctgggg acagacacac     1980

agcccctgcc tctgtaggag actgtcctgt tctgtgagcg ccctgtcctc cgacctccat     2040

gcccactcgg gggcatgcct agtccatgcg cgtagggaca ggccctccct cacccatcta     2100

cccccacggc actaacccct ggcagccctg cccagcctcg cacccgcatg gggacacaac     2160

cgactccggg gacatgcact ctcgggccct gtggagggac tggtgcagat gcccacacac     2220

acactcagcc cagacccgtt caacaaaccc cgcactgagg ttggccggcc acacggccac     2280

cacacacaca cgtgcacgcc tcacacacgg agcctcaccc gggcgaaccg cacagcaccc     2340

agaccagagc aaggtcctcg cacacgtgaa cactcctcgg acacaggccc ccacgagccc     2400

cacgcggcac ctcaaggccc acgagccgct cggcagcttc tccacatgct gacctgctca     2460

gacaaaccca gccctcctct cacaaggtgc ccctgcagcc gccacacaca cacaggcccc     2520

cacacgcagg ggaacacacg ccacgtcgcg tccctggcac tggcccactt cccaatacag     2580

cccttccctg cagctggggt cacatgaggt gtgggcttca ccatcctcct gccctctggg     2640

cctcagggag ggacacggga gacggggagc gggtcctgct gagggccagg tcgctatcta     2700

gggccgggtg tctggctgag tcccggggcc aaagctggtg cccagggcgg gcagctgtgg     2760

ggagctgacc tcaggacatt gttggcccat cccggccggg ccctacatcc tgggccccgc     2820

cacagaggga atcaccccca gaggcccaag cccaggggga cacagcactg accaccccct     2880

tcctgtccag agctgcaact ggaggagagc tgtgcggagg cgcaggacgg ggagctggac     2940

gggctgtgga cgaccatcac catcttcatc acactcttcc tgttaagcgt gtgctacagt     3000

gccaccgtca ccttcttcaa ggtcggccgc acgttgtccc cagctgtcct tgacattgtc     3060

ccccatgctg tcacaaactg tctctgacac tgtcccacag gctgtcccca cctgtccctg     3120

acgctgtccc ccatgctctc acaaactgtc cctgacattg tccccaatgc tgcccccacc     3180

tgtccaacag tgtcccccag gctctcccca catgtccccg acactgtccc ccatgctgtc     3240

cccatctgtc cccaacactg tcccccaccc tgtccccctt tgtccccaac actgtccccc     3300

acagtttcca cctgtccctg acactgtccc ccatgctttc cccacctgtc cctgacacca     3360

tcccccactc tgtcccctat agttcctggc cctgtccccc acgctgtccc ctacagtacc     3420

tggcactgtc ccccatgctg tcccctcctg tatgaaaccc tgtcccacat gctgtcccca     3480

cctgtccgtg acaatatccc ccacactgtc cccacctgtc cccgacactc tcctccacgt     3540

tgttcttacc taaacccgac actttcctcc atgctgtccc cacccatctc cgacactgta     3600

ccccacgttg tccccacctg tcctcaacac tgtcccccat gctgtcccca cctgtcccca     3660

acactctcct ccatgctgtc cccacctgtc cctgatattg tcccccatgc agtctccacc     3720

tgtccccaat gctgtccccc aggctgtacc taccagtaca acactgtccc ccatgctgtc     3780

cccacctgtc cctgacactg tcccccacgc tgtcccctcc tgtccccgac actgtccccc     3840

acactgtccc cacctgtccc caacactatc ctccatgctg tcccctcctg tccccacctg     3900

tcccctacac tgtcccccat gctgtcccca ccagtcccca aaactttcct ccacactgtc     3960

cccacctgtc cccaacactg tcccccacgc tatcccccct gtccccgaca atgtccccac     4020

tgtttcctcc tgttccctcc tatccctgac actgtccgcc atgctgtccc cacctgtccc     4080

tgacactgtc tcccactctg tcccctataa tccctgacac tgtcccccac gccgtcccct     4140

cccgtatgca ccactgtccc ccaagctgtc cccacctgtc ctcaacacag tcccccatgc     4200

tgtccccacc tgtccccaac actctcctcc atgtccccac ctgtccctga tattgtcccc     4260

catgcagtcc ccacctgtcc ccgatgctgt cccccgggct gtacctacca gtccaacact     4320

gtcccccaca ctctccccac ctgtccctga tactgtcccc catgctgtcc ccacctgtcc     4380

cggacactgt tctccacgat ctcccctcct gtccctgaca ctgtccccca cactgtcccc     4440

acctgtcccc aacactatcc tccatcctgt cccaacctgt ctcctacact gtcccccatg     4500

ctgtccccac cagtccccaa cactgtcctc catgctgtcc cccatgtccc caacactgtc     4560

ccccatgcta cctcccctgc ccctgacaat gtccccactg tttcctgtcc cctcctatcc     4620

ctgacactgt cccccatgct gtccccacct gtcccccaca tggtctccac cggtccctga     4680

cactgtctcc cactctgtcc cctataatcc ctgacactgt cccccacacc gtcccctcct     4740

gtatgcacca cggtccccca tgctgtcccc acctgtccct gatgctgtcc tccacacagt     4800

ccccacctct ccctgacact gtccccatct ctccccaaca ctctcctcca tgctgtcctc     4860

aactgtcccc aacactcttc cacactctgt ctccacctgt ccctgacact gtcccccaca     4920

ctgtcctcac ctgtgtctga cactgtcccc cacgctgtcc ccacctgtcc ctgacgctgt     4980

cttctgtgct gtccacatgc tgttggtgcc ctggctctgc tctctatcac caagcctcag     5040

agcaggcagt ggtgaggcca tggcacctgg gtggcatgag gggccggatg ggcctcaggg     5100

gcagggctgt ggcctgcgtg gactgacagg tgggtgggcc ttgggggcag agaggtggcc     5160

tcagtgccct gaggggtggg tggggctcgg gggcagggct gtggcctcgc tcacccctgt     5220

gctgtgcctt gcctacaggt gaagtggatc ttctcctcgg tggtggacct gaagcagacc     5280

atcatccccg actacaggaa catgatcgga cagggggcct agggccaccc tctgcggggt     5340

gtccagggcc gcccagaccc cacacaccag ccatgggcca tgctcagcca ccacccaggc     5400

cacacctgcc cccgacctca ccgccctcaa ccccatggct ctctggcctc gcagttgccc     5460

tctgaccctg acacacctga cacgcccccc ttccagaccc tgtgcatagc aggtctaccc     5520

cagacctccg ctgcttggtg cctgcagggc actgggggcc aggtgtcccc tcagcaggac     5580

gtccttgccc tccggaccac aaggtgctca cacaaaagga ggcagtgacc ggtatcccag     5640

gcccccaccc aggcaggagc tggccctgga gccaaccccg tccacgccag cctcctgaac     5700

acaggcgtgg tttccagatg gtgagtggga gcatcagccg ccaaggtagg gaagccacag     5760

caccatcagg ccctgttggg gaggcttccg agagctgcga aggctcactc agacggcctt     5820

cctcccagcc cgcagccagc cagcctccat tccgggcact cccgtgaact cctgacatga     5880

ggaatgacgt tgttctgatt tcaagcaaag aacgctgctc tctggctcct gggaacagtc     5940

tcggtgccag caccacccct tggctgcctg cccacactgc tggattctcg ggtggaactc     6000

gacccgcagg gacagccagc cccagagtcc gcactgggga gagaaggggc caggcccagg     6060

acactgccac ctcccaccca ctccagtcca ccgagatcac tcggagaaga gtctgggcca     6120

tgtggccgct gcaggagccc cacagtgcaa gggtgaggat agcccaagga agggctgggc     6180

atctgcccag acaggcctcc cacagaaggc tggtgaccag gtcccaggcg ggcaagactc     6240

agccttggtg gggcctgagg acagaggagg cccaggagca tcggggagag aggtggaggg     6300

acaccgggag agccaggggc gtggacacag ccagaactca tcacagaggc tggcgtccag     6360

tcccgggtca tgtgcagcag gaacaagcag ccactctggg ggcaccaggt ggagaggcaa     6420

gacgacaaag agggtgcccg tgttcttgcg aaagcggggc tgctggccac gagtgctgga     6480

cagaggcccc cacgctctgc tgcccccatc acgccgttcc gtgactgtca cgcagaatct     6540

gcagacagga agggagactc gagcgggagt gcggccagag cctgcctcgg ccgtcaggga     6600

ggactcccgg gctcactcga aggaggtgcc accatttcag ctttggtagc ttttcttctt     6660

cttttaaatt ttctaaagct cattaattgt ctttgatgtt tcttttgtga tgacaataaa     6720

atatcctttt taagtcttgt acttcgtgat gggagccgcc ttcctgtgtc cacgcgcctc     6780

ctgcccccgg tgggaagcac ggtcaggagg aggctggtcc agctgcacct cgggggctcc     6840

ctgcactcgc cccccgcctc ctgcagccac acgcattgcc cgagcgaccc tccctggccc     6900

ctgtcactac atggaccccc ggggcttctc ctcttttcta catggatcc                 6949


<210>  27
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  28
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys 
                325                 330                 335     


Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
            340                 345                 350         


Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val 
        355                 360                 365             


Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys 
    370                 375                 380                 


Gln Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
385                 390                 395                 


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated 3'-fragment of intron 6

<400>  29
ctaccacccc cttcctgtcc ag                                                22


<210>  30
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated 3'-fragment of intron 6 with exon fragment

<400>  30
ctaccacccc cttcctgtcc agagctg                                           27


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated 3'-fragment of intron 6 II

<400>  31
ctaccacgcc aatcgtgtcc ag                                                22


<210>  32
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated 3'-fragment of intron 6 II with exon fragment

<400>  32
ctaccacgcc aatcgtgtcc agagctg                                           27


