                         SEQUENCE LISTING

<110>  Laboratorios del Dr. ESTEVE S.A.
       Universitat Autnoma de Barcelona
 
<120>  ADENOASSOCIATED VIRUS VECTORS FOR THE TREATMENT OF 
       MUCOPOLYSACCHARIDOSES

<130>  PCT2212.7

<150>  EP16382450
<151>  2016-09-30

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcggctcc tgcctctagc cccaggtcgg ctccggcggg gcagcccccg ccacctgccc       60

tcctgcagcc cagcgctgct actgctggtg ctgggcggct gcctgggggt cttcggggtg      120

gctgcgggaa cccggaggcc caacgtggtg ctgctcctca cggacgacca ggacgaagtg      180

ctcggcggca tgacaccgct aaagaaaacc aaagctctca tcggagagat ggggatgact      240

ttttccagtg cttatgtgcc aagtgctctc tgctgcccca gcagagccag tatcctgaca      300

ggaaagtacc cacataatca tcacgttgtg aacaacactc tggaggggaa ctgcagtagt      360

aagtcctggc agaagatcca agaaccaaat actttcccag caattctcag atcaatgtgt      420

ggttatcaga ccttttttgc agggaaatat ttaaatgagt acggagcccc agatgcaggt      480

ggactagaac acgttcctct gggttggagt tactggtatg ccttggaaaa gaattctaag      540

tattataatt acaccctgtc tatcaatggg aaggcacgga agcatggtga aaactatagt      600

gtggactacc tgacagatgt tttggctaat gtctccttgg actttctgga ctacaagtcc      660

aactttgagc ccttcttcat gatgatcgcc actccagcgc ctcattcgcc ttggacagct      720

gcacctcagt accagaaggc tttccagaat gtctttgcac caagaaacaa gaacttcaac      780

atccatggaa cgaacaagca ctggttaatt aggcaagcca agactccaat gactaattct      840

tcaatacagt ttttagataa tgcatttagg aaaaggtggc aaactctcct ctcagttgat      900

gaccttgtgg agaaactggt caagaggctg gagttcactg gggagctcaa caacacttac      960

atcttctata cctcagacaa tggctatcac acaggacagt tttccttgcc aatagacaag     1020

agacagctgt atgagtttga tatcaaagtt ccactgttgg ttcgaggacc tgggatcaaa     1080

ccaaatcaga caagcaagat gctggttgcc aacattgact tgggtcctac tattttggac     1140

attgctggct acgacctaaa taagacacag atggatggga tgtccttatt gcccattttg     1200

agaggtgcca gtaacttgac ctggcgatca gatgtcctgg tggaatacca aggagaaggc     1260

cgtaacgtca ctgacccaac atgcccttcc ctgagtcctg gcgtatctca atgcttccca     1320

gactgtgtat gtgaagatgc ttataacaat acctatgcct gtgtgaggac aatgtcagca     1380

ttgtggaatt tgcagtattg cgagtttgat gaccaggagg tgtttgtaga agtctataat     1440

ctgactgcag acccagacca gatcactaac attgctaaaa ccatagaccc agagctttta     1500

ggaaagatga actatcggtt aatgatgtta cagtcctgtt ctgggccaac ctgtcgcact     1560

ccaggggttt ttgaccccgg atacaggttt gacccccgtc tcatgttcag caatcgcggc     1620

agtgtcagga ctcgaagatt ttccaaacat cttctgtag                            1659


<210>  2
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-version1

<400>  2
atgagactgc tgcctctggc tcctggccgg ctgagaagag gcagccctag acatctgccc       60

agctgctctc cagccctgct gctgctggtg ctgggaggat gcctgggagt gtttggagtg      120

gccgctggca ccagacggcc caatgtggtg ctgctgctga ccgacgacca ggacgaagtg      180

ctgggcggca tgacccccct gaaaaagacc aaggccctga tcggcgagat gggcatgacc      240

ttcagcagcg cctatgtgcc cagcgccctg tgctgtccta gcagagccag catcctgacc      300

ggcaagtacc cccacaacca ccatgtcgtg aacaacaccc tggaaggcaa ctgcagcagc      360

aagagctggc agaagatcca ggaacccaac accttccccg ccatcctgag atccatgtgc      420

ggctaccaga ccttcttcgc cggaaagtac ctgaacgagt acggcgctcc tgacgctggc      480

ggactggaac atgtgcctct gggctggtcc tattggtacg ccctggaaaa gaacagcaag      540

tactacaact acaccctgag catcaacggc aaggcccgga agcacggcga gaactacagc      600

gtggactacc tgaccgatgt gctggccaac gtgtccctgg acttcctgga ctacaagagc      660

aacttcgagc ccttcttcat gatgatcgcc acccctgccc cccacagccc ttggacagct      720

gctcctcagt accagaaagc cttccagaac gtgttcgccc ccagaaacaa gaacttcaac      780

atccacggca ccaacaagca ctggctgatc cggcaggcca agacccccat gaccaacagc      840

agcatccagt ttctggacaa cgccttcaga aagcggtggc agaccctgct gtccgtggac      900

gacctggtgg aaaagctcgt gaagcggctg gagttcaccg gcgagctgaa caatacctac      960

atcttctaca ccagcgacaa cggctaccac accggccagt tcagcctgcc catcgacaag     1020

cggcagctgt acgagttcga catcaaggtg cccctgctcg tgcggggacc tggcatcaag     1080

cctaaccaga cctccaagat gctggtggcc aacatcgacc tgggccccac catcctggat     1140

atcgccggct acgacctgaa caagacccag atggacggca tgtccctgct gcctatcctg     1200

agaggcgcca gcaatctgac atggcggagc gacgtgctgg tggaatatca gggcgagggc     1260

cggaacgtga ccgaccctac atgtcctagc ctgagccctg gcgtgtccca gtgcttccct     1320

gattgcgtgt gcgaggacgc ctacaacaac acctacgcct gcgtgcggac catgtccgcc     1380

ctgtggaacc tgcagtattg cgagttcgat gaccaggaag tgttcgtgga agtgtacaac     1440

ctgaccgccg accccgacca gatcaccaat atcgccaaga ccatcgaccc cgagctgctg     1500

ggaaagatga actaccggct gatgatgctg cagagctgca gcggccctac ctgcagaaca     1560

ccaggcgtgt tcgaccccgg ctacagattc gaccccagac tgatgttcag caaccggggc     1620

tccgtgcgca ccagaagatt cagcaaacat ctgctctga                            1659


<210>  3
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-version2

<400>  3
atgaggctgc tgcccctggc ccccggaagg ttgcggcggg gttcgcctag acacctccct       60

tcatgctctc ccgccctgtt gctgctcgtg ctcggcggat gcctcggggt gttcggggtg      120

gccgcgggca cccggcgccc gaacgtcgtg ctgctgctga ccgacgacca agacgaggtg      180

ctcggtggca tgaccccgct gaagaaaacc aaggcgctga tcggtgaaat gggcatgacc      240

ttctcctccg catacgtgcc ctcggccctt tgctgtccgt cccgcgcgtc catcctgacc      300

gggaagtacc cgcataatca ccacgtcgtg aacaacactc tcgaggggaa ctgcagctcc      360

aagtcctggc agaagatcca agagcccaat accttccctg ctatcctgcg gtcgatgtgc      420

ggataccaga ccttctttgc cggaaagtat ctgaacgaat acggagcacc agatgccggt      480

ggactggaac atgtgccgct gggatggagc tattggtacg cactggagaa gaactccaag      540

tactacaatt acaccctgtc catcaacggg aaggcccgca agcacggcga aaactattcc      600

gtggactacc tcaccgacgt gctggccaac gtgtcgctgg atttccttga ctacaagtcc      660

aactttgagc ccttcttcat gatgatcgcc actccggcgc cccatagccc ctggaccgcc      720

gcgcctcagt accaaaaggc tttccagaac gtgttcgccc caagaaacaa gaacttcaat      780

attcacggaa ctaacaagca ctggctgatc agacaggcca aaactccaat gaccaactcg      840

agcatccagt tcctggacaa cgccttccgg aagcgctggc agaccctgct ctccgtggat      900

gacctggtgg aaaagctggt caagcggctg gagttcactg gggagttgaa caacacctat      960

atcttctaca cctccgacaa tggttaccac accggacagt tctcgctgcc aattgacaag     1020

cggcagctgt acgagttcga tattaaggtc ccacttcttg tgcgcgggcc gggaatcaag     1080

cccaaccaaa cttccaagat gctggtcgcc aacattgacc tgggtccgac tattctcgat     1140

atcgccggct acgacctgaa caagactcag atggacggca tgagcttgct gccgatcctg     1200

cgcggagcgt ccaacctgac ttggaggtcc gacgtcttgg tggaatacca gggcgaaggg     1260

cgcaacgtca ccgacccaac ttgcccttca ctgtcacccg gagtgtccca gtgcttcccc     1320

gactgcgtgt gtgaagatgc ctacaacaat acctacgcct gcgtgcgcac catgtccgct     1380

ctctggaacc tccagtactg cgaatttgac gaccaggagg tgttcgtgga agtgtacaac     1440

ctgacagccg atcctgacca aatcaccaac attgcaaaga ccatcgaccc tgagctgctg     1500

ggaaagatga actacaggct gatgatgctc cagagctgct ccggcccgac gtgccggacg     1560

ccgggagtgt ttgaccctgg ataccggttc gacccgagac tgatgttctc aaaccggggc     1620

tcggtccgga cccgaagatt cagcaaacac ctcctctga                            1659


<210>  4
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-version3

<400>  4
atgcgactgc tgccactggc tcctggaaga ctgagacgag ggtcaccaag acatctgcct       60

agttgttcac ctgctctgct gctgctggtg ctgggcggct gcctgggcgt gttcggagtg      120

gcagcaggaa cccggcggcc caacgtggtg ctgctgctga cagacgatca ggacgaggtg      180

ctgggaggaa tgacccccct gaagaagaca aaggccctga tcggcgagat gggcatgacc      240

tttagctccg cctacgtgcc tagcgccctg tgctgtccaa gccgggcctc tatcctgacc      300

ggcaagtatc cacacaatca ccacgtggtg aacaatacac tggagggcaa ctgctctagc      360

aagtcttggc agaagatcca ggagcctaat accttcccag ccatcctgag aagcatgtgc      420

ggctaccaga cattctttgc cggcaagtac ctgaacgagt atggcgcccc agatgcagga      480

ggcctggagc acgtgccact gggatggagc tactggtatg ccctggagaa gaacagcaag      540

tactataact acacactgag catcaatggc aaggccagga agcacggcga gaactactcc      600

gtggactatc tgaccgatgt gctggccaac gtgagcctgg acttcctgga ttacaagtct      660

aactttgagc ccttctttat gatgatcgca accccagcac ctcacagccc atggacagcc      720

gccccccagt atcagaaggc cttccagaac gtgttcgccc ctcggaacaa gaacttcaac      780

atccacggca ccaacaagca ctggctgatc agacaggcca agaccccaat gacaaattcc      840

tctatccagt tcctggacaa cgcctttagg aagcggtggc agaccctgct gtccgtggac      900

gatctggtgg agaagctggt gaagagactg gagttcacag gcgagctgaa caacacctac      960

atcttttata caagcgataa cggctaccac accggccagt tctccctgcc catcgacaag     1020

aggcagctgt atgagtttga tatcaaggtg cctctgctgg tgcgcggccc cggcatcaag     1080

cctaatcaga catctaagat gctggtggcc aacatcgacc tgggaccaac catcctggac     1140

atcgcaggct acgatctgaa caagacacag atggatggca tgtccctgct gcctatcctg     1200

aggggagcaa gcaatctgac ctggcgctcc gacgtgctgg tggagtatca gggcgagggc     1260

aggaacgtga ccgatccaac atgcccaagc ctgtcccccg gcgtgtccca gtgtttccct     1320

gactgcgtgt gcgaggatgc ctacaacaat acctatgcct gcgtgcgcac aatgtctgcc     1380

ctgtggaatc tgcagtactg tgagttcgac gatcaggagg tgtttgtgga ggtgtataat     1440

ctgaccgccg accctgatca gatcaccaac atcgccaaga caatcgaccc agagctgctg     1500

ggcaagatga actaccggct gatgatgctg cagtcttgca gcggccctac ctgtagaaca     1560

ccaggcgtgt tcgaccccgg ctatcggttt gatcctagac tgatgttttc caatagaggc     1620

tccgtgagga ctcggcggtt tagtaagcac ctgctgtaa                            1659


<210>  5
<211>  7894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-hGNS

<400>  5
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcggc tcctgcctct agccccaggt cggctccggc ggggcagccc     1980

ccgccacctg ccctcctgca gcccagcgct gctactgctg gtgctgggcg gctgcctggg     2040

ggtcttcggg gtggctgcgg gaacccggag gcccaacgtg gtgctgctcc tcacggacga     2100

ccaggacgaa gtgctcggcg gcatgacacc gctaaagaaa accaaagctc tcatcggaga     2160

gatggggatg actttttcca gtgcttatgt gccaagtgct ctctgctgcc ccagcagagc     2220

cagtatcctg acaggaaagt acccacataa tcatcacgtt gtgaacaaca ctctggaggg     2280

gaactgcagt agtaagtcct ggcagaagat ccaagaacca aatactttcc cagcaattct     2340

cagatcaatg tgtggttatc agaccttttt tgcagggaaa tatttaaatg agtacggagc     2400

cccagatgca ggtggactag aacacgttcc tctgggttgg agttactggt atgccttgga     2460

aaagaattct aagtattata attacaccct gtctatcaat gggaaggcac ggaagcatgg     2520

tgaaaactat agtgtggact acctgacaga tgttttggct aatgtctcct tggactttct     2580

ggactacaag tccaactttg agcccttctt catgatgatc gccactccag cgcctcattc     2640

gccttggaca gctgcacctc agtaccagaa ggctttccag aatgtctttg caccaagaaa     2700

caagaacttc aacatccatg gaacgaacaa gcactggtta attaggcaag ccaagactcc     2760

aatgactaat tcttcaatac agtttttaga taatgcattt aggaaaaggt ggcaaactct     2820

cctctcagtt gatgaccttg tggagaaact ggtcaagagg ctggagttca ctggggagct     2880

caacaacact tacatcttct atacctcaga caatggctat cacacaggac agttttcctt     2940

gccaatagac aagagacagc tgtatgagtt tgatatcaaa gttccactgt tggttcgagg     3000

acctgggatc aaaccaaatc agacaagcaa gatgctggtt gccaacattg acttgggtcc     3060

tactattttg gacattgctg gctacgacct aaataagaca cagatggatg ggatgtcctt     3120

attgcccatt ttgagaggtg ccagtaactt gacctggcga tcagatgtcc tggtggaata     3180

ccaaggagaa ggccgtaacg tcactgaccc aacatgccct tccctgagtc ctggcgtatc     3240

tcaatgcttc ccagactgtg tatgtgaaga tgcttataac aatacctatg cctgtgtgag     3300

gacaatgtca gcattgtgga atttgcagta ttgcgagttt gatgaccagg aggtgtttgt     3360

agaagtctat aatctgactg cagacccaga ccagatcact aacattgcta aaaccataga     3420

cccagagctt ttaggaaaga tgaactatcg gttaatgatg ttacagtcct gttctgggcc     3480

aacctgtcgc actccagggg tttttgaccc cggatacagg tttgaccccc gtctcatgtt     3540

cagcaatcgc ggcagtgtca ggactcgaag attttccaaa catcttctgt aggaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt     4320

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4380

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4440

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4500

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4560

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4620

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4680

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4740

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4800

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4860

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4920

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4980

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5040

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5100

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5160

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     5220

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     5280

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5340

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5400

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5460

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5520

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5580

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5640

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5700

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5760

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5820

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5880

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5940

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6000

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6060

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6120

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6180

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     6240

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6300

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6360

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     6420

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     6480

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     6540

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     6600

tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag     6660

caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa     6720

tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata     6780

tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc     6840

ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc     6900

ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt     6960

ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt     7020

accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa     7080

attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt     7140

tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata     7200

gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac     7260

gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa     7320

tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc     7380

cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg     7440

aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca     7500

cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta     7560

taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat     7620

tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc     7680

gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt     7740

aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag     7800

aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact     7860

gttgggaagg gcgatcggtg cgggcctctt cgct                                 7894


<210>  6
<211>  7894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGNS-version1

<400>  6
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgagac tgctgcctct ggctcctggc cggctgagaa gaggcagccc     1980

tagacatctg cccagctgct ctccagccct gctgctgctg gtgctgggag gatgcctggg     2040

agtgtttgga gtggccgctg gcaccagacg gcccaatgtg gtgctgctgc tgaccgacga     2100

ccaggacgaa gtgctgggcg gcatgacccc cctgaaaaag accaaggccc tgatcggcga     2160

gatgggcatg accttcagca gcgcctatgt gcccagcgcc ctgtgctgtc ctagcagagc     2220

cagcatcctg accggcaagt acccccacaa ccaccatgtc gtgaacaaca ccctggaagg     2280

caactgcagc agcaagagct ggcagaagat ccaggaaccc aacaccttcc ccgccatcct     2340

gagatccatg tgcggctacc agaccttctt cgccggaaag tacctgaacg agtacggcgc     2400

tcctgacgct ggcggactgg aacatgtgcc tctgggctgg tcctattggt acgccctgga     2460

aaagaacagc aagtactaca actacaccct gagcatcaac ggcaaggccc ggaagcacgg     2520

cgagaactac agcgtggact acctgaccga tgtgctggcc aacgtgtccc tggacttcct     2580

ggactacaag agcaacttcg agcccttctt catgatgatc gccacccctg ccccccacag     2640

cccttggaca gctgctcctc agtaccagaa agccttccag aacgtgttcg cccccagaaa     2700

caagaacttc aacatccacg gcaccaacaa gcactggctg atccggcagg ccaagacccc     2760

catgaccaac agcagcatcc agtttctgga caacgccttc agaaagcggt ggcagaccct     2820

gctgtccgtg gacgacctgg tggaaaagct cgtgaagcgg ctggagttca ccggcgagct     2880

gaacaatacc tacatcttct acaccagcga caacggctac cacaccggcc agttcagcct     2940

gcccatcgac aagcggcagc tgtacgagtt cgacatcaag gtgcccctgc tcgtgcgggg     3000

acctggcatc aagcctaacc agacctccaa gatgctggtg gccaacatcg acctgggccc     3060

caccatcctg gatatcgccg gctacgacct gaacaagacc cagatggacg gcatgtccct     3120

gctgcctatc ctgagaggcg ccagcaatct gacatggcgg agcgacgtgc tggtggaata     3180

tcagggcgag ggccggaacg tgaccgaccc tacatgtcct agcctgagcc ctggcgtgtc     3240

ccagtgcttc cctgattgcg tgtgcgagga cgcctacaac aacacctacg cctgcgtgcg     3300

gaccatgtcc gccctgtgga acctgcagta ttgcgagttc gatgaccagg aagtgttcgt     3360

ggaagtgtac aacctgaccg ccgaccccga ccagatcacc aatatcgcca agaccatcga     3420

ccccgagctg ctgggaaaga tgaactaccg gctgatgatg ctgcagagct gcagcggccc     3480

tacctgcaga acaccaggcg tgttcgaccc cggctacaga ttcgacccca gactgatgtt     3540

cagcaaccgg ggctccgtgc gcaccagaag attcagcaaa catctgctct gagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt     4320

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4380

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4440

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4500

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4560

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4620

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4680

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4740

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4800

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4860

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4920

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4980

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5040

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5100

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5160

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     5220

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     5280

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5340

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5400

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5460

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5520

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5580

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5640

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5700

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5760

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5820

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5880

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5940

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6000

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6060

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6120

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6180

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     6240

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6300

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6360

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     6420

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     6480

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     6540

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     6600

tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag     6660

caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa     6720

tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata     6780

tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc     6840

ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc     6900

ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt     6960

ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt     7020

accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa     7080

attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt     7140

tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata     7200

gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac     7260

gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa     7320

tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc     7380

cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg     7440

aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca     7500

cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta     7560

taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat     7620

tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc     7680

gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt     7740

aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag     7800

aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact     7860

gttgggaagg gcgatcggtg cgggcctctt cgct                                 7894


<210>  7
<211>  7894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGNS-version2

<400>  7
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgaggc tgctgcccct ggcccccgga aggttgcggc ggggttcgcc     1980

tagacacctc ccttcatgct ctcccgccct gttgctgctc gtgctcggcg gatgcctcgg     2040

ggtgttcggg gtggccgcgg gcacccggcg cccgaacgtc gtgctgctgc tgaccgacga     2100

ccaagacgag gtgctcggtg gcatgacccc gctgaagaaa accaaggcgc tgatcggtga     2160

aatgggcatg accttctcct ccgcatacgt gccctcggcc ctttgctgtc cgtcccgcgc     2220

gtccatcctg accgggaagt acccgcataa tcaccacgtc gtgaacaaca ctctcgaggg     2280

gaactgcagc tccaagtcct ggcagaagat ccaagagccc aataccttcc ctgctatcct     2340

gcggtcgatg tgcggatacc agaccttctt tgccggaaag tatctgaacg aatacggagc     2400

accagatgcc ggtggactgg aacatgtgcc gctgggatgg agctattggt acgcactgga     2460

gaagaactcc aagtactaca attacaccct gtccatcaac gggaaggccc gcaagcacgg     2520

cgaaaactat tccgtggact acctcaccga cgtgctggcc aacgtgtcgc tggatttcct     2580

tgactacaag tccaactttg agcccttctt catgatgatc gccactccgg cgccccatag     2640

cccctggacc gccgcgcctc agtaccaaaa ggctttccag aacgtgttcg ccccaagaaa     2700

caagaacttc aatattcacg gaactaacaa gcactggctg atcagacagg ccaaaactcc     2760

aatgaccaac tcgagcatcc agttcctgga caacgccttc cggaagcgct ggcagaccct     2820

gctctccgtg gatgacctgg tggaaaagct ggtcaagcgg ctggagttca ctggggagtt     2880

gaacaacacc tatatcttct acacctccga caatggttac cacaccggac agttctcgct     2940

gccaattgac aagcggcagc tgtacgagtt cgatattaag gtcccacttc ttgtgcgcgg     3000

gccgggaatc aagcccaacc aaacttccaa gatgctggtc gccaacattg acctgggtcc     3060

gactattctc gatatcgccg gctacgacct gaacaagact cagatggacg gcatgagctt     3120

gctgccgatc ctgcgcggag cgtccaacct gacttggagg tccgacgtct tggtggaata     3180

ccagggcgaa gggcgcaacg tcaccgaccc aacttgccct tcactgtcac ccggagtgtc     3240

ccagtgcttc cccgactgcg tgtgtgaaga tgcctacaac aatacctacg cctgcgtgcg     3300

caccatgtcc gctctctgga acctccagta ctgcgaattt gacgaccagg aggtgttcgt     3360

ggaagtgtac aacctgacag ccgatcctga ccaaatcacc aacattgcaa agaccatcga     3420

ccctgagctg ctgggaaaga tgaactacag gctgatgatg ctccagagct gctccggccc     3480

gacgtgccgg acgccgggag tgtttgaccc tggataccgg ttcgacccga gactgatgtt     3540

ctcaaaccgg ggctcggtcc ggacccgaag attcagcaaa cacctcctct gagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt     4320

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4380

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4440

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4500

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4560

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4620

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4680

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4740

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4800

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4860

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4920

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4980

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5040

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5100

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5160

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     5220

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     5280

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5340

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5400

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5460

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5520

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5580

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5640

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5700

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5760

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5820

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5880

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5940

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6000

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6060

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6120

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6180

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     6240

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6300

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6360

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     6420

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     6480

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     6540

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     6600

tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag     6660

caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa     6720

tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata     6780

tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc     6840

ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc     6900

ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt     6960

ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt     7020

accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa     7080

attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt     7140

tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata     7200

gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac     7260

gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa     7320

tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc     7380

cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg     7440

aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca     7500

cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta     7560

taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat     7620

tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc     7680

gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt     7740

aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag     7800

aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact     7860

gttgggaagg gcgatcggtg cgggcctctt cgct                                 7894


<210>  8
<211>  7894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohGNS-version3

<400>  8
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcgac tgctgccact ggctcctgga agactgagac gagggtcacc     1980

aagacatctg cctagttgtt cacctgctct gctgctgctg gtgctgggcg gctgcctggg     2040

cgtgttcgga gtggcagcag gaacccggcg gcccaacgtg gtgctgctgc tgacagacga     2100

tcaggacgag gtgctgggag gaatgacccc cctgaagaag acaaaggccc tgatcggcga     2160

gatgggcatg acctttagct ccgcctacgt gcctagcgcc ctgtgctgtc caagccgggc     2220

ctctatcctg accggcaagt atccacacaa tcaccacgtg gtgaacaata cactggaggg     2280

caactgctct agcaagtctt ggcagaagat ccaggagcct aataccttcc cagccatcct     2340

gagaagcatg tgcggctacc agacattctt tgccggcaag tacctgaacg agtatggcgc     2400

cccagatgca ggaggcctgg agcacgtgcc actgggatgg agctactggt atgccctgga     2460

gaagaacagc aagtactata actacacact gagcatcaat ggcaaggcca ggaagcacgg     2520

cgagaactac tccgtggact atctgaccga tgtgctggcc aacgtgagcc tggacttcct     2580

ggattacaag tctaactttg agcccttctt tatgatgatc gcaaccccag cacctcacag     2640

cccatggaca gccgcccccc agtatcagaa ggccttccag aacgtgttcg cccctcggaa     2700

caagaacttc aacatccacg gcaccaacaa gcactggctg atcagacagg ccaagacccc     2760

aatgacaaat tcctctatcc agttcctgga caacgccttt aggaagcggt ggcagaccct     2820

gctgtccgtg gacgatctgg tggagaagct ggtgaagaga ctggagttca caggcgagct     2880

gaacaacacc tacatctttt atacaagcga taacggctac cacaccggcc agttctccct     2940

gcccatcgac aagaggcagc tgtatgagtt tgatatcaag gtgcctctgc tggtgcgcgg     3000

ccccggcatc aagcctaatc agacatctaa gatgctggtg gccaacatcg acctgggacc     3060

aaccatcctg gacatcgcag gctacgatct gaacaagaca cagatggatg gcatgtccct     3120

gctgcctatc ctgaggggag caagcaatct gacctggcgc tccgacgtgc tggtggagta     3180

tcagggcgag ggcaggaacg tgaccgatcc aacatgccca agcctgtccc ccggcgtgtc     3240

ccagtgtttc cctgactgcg tgtgcgagga tgcctacaac aatacctatg cctgcgtgcg     3300

cacaatgtct gccctgtgga atctgcagta ctgtgagttc gacgatcagg aggtgtttgt     3360

ggaggtgtat aatctgaccg ccgaccctga tcagatcacc aacatcgcca agacaatcga     3420

cccagagctg ctgggcaaga tgaactaccg gctgatgatg ctgcagtctt gcagcggccc     3480

tacctgtaga acaccaggcg tgttcgaccc cggctatcgg tttgatccta gactgatgtt     3540

ttccaataga ggctccgtga ggactcggcg gtttagtaag cacctgctgt aagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt     4320

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4380

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4440

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4500

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4560

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4620

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4680

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4740

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4800

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4860

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4920

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4980

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5040

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5100

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5160

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     5220

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     5280

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5340

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5400

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5460

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5520

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5580

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5640

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5700

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5760

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5820

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5880

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5940

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6000

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6060

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6120

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6180

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     6240

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6300

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6360

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     6420

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     6480

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     6540

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     6600

tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag     6660

caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa     6720

tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata     6780

tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc     6840

ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc     6900

ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt     6960

ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt     7020

accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa     7080

attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt     7140

tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata     7200

gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac     7260

gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa     7320

tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc     7380

cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg     7440

aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca     7500

cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta     7560

taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat     7620

tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc     7680

gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt     7740

aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag     7800

aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact     7860

gttgggaagg gcgatcggtg cgggcctctt cgct                                 7894


<210>  9
<211>  4313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-hGNS

<400>  9
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcggc tcctgcctct agccccaggt cggctccggc ggggcagccc     1980

ccgccacctg ccctcctgca gcccagcgct gctactgctg gtgctgggcg gctgcctggg     2040

ggtcttcggg gtggctgcgg gaacccggag gcccaacgtg gtgctgctcc tcacggacga     2100

ccaggacgaa gtgctcggcg gcatgacacc gctaaagaaa accaaagctc tcatcggaga     2160

gatggggatg actttttcca gtgcttatgt gccaagtgct ctctgctgcc ccagcagagc     2220

cagtatcctg acaggaaagt acccacataa tcatcacgtt gtgaacaaca ctctggaggg     2280

gaactgcagt agtaagtcct ggcagaagat ccaagaacca aatactttcc cagcaattct     2340

cagatcaatg tgtggttatc agaccttttt tgcagggaaa tatttaaatg agtacggagc     2400

cccagatgca ggtggactag aacacgttcc tctgggttgg agttactggt atgccttgga     2460

aaagaattct aagtattata attacaccct gtctatcaat gggaaggcac ggaagcatgg     2520

tgaaaactat agtgtggact acctgacaga tgttttggct aatgtctcct tggactttct     2580

ggactacaag tccaactttg agcccttctt catgatgatc gccactccag cgcctcattc     2640

gccttggaca gctgcacctc agtaccagaa ggctttccag aatgtctttg caccaagaaa     2700

caagaacttc aacatccatg gaacgaacaa gcactggtta attaggcaag ccaagactcc     2760

aatgactaat tcttcaatac agtttttaga taatgcattt aggaaaaggt ggcaaactct     2820

cctctcagtt gatgaccttg tggagaaact ggtcaagagg ctggagttca ctggggagct     2880

caacaacact tacatcttct atacctcaga caatggctat cacacaggac agttttcctt     2940

gccaatagac aagagacagc tgtatgagtt tgatatcaaa gttccactgt tggttcgagg     3000

acctgggatc aaaccaaatc agacaagcaa gatgctggtt gccaacattg acttgggtcc     3060

tactattttg gacattgctg gctacgacct aaataagaca cagatggatg ggatgtcctt     3120

attgcccatt ttgagaggtg ccagtaactt gacctggcga tcagatgtcc tggtggaata     3180

ccaaggagaa ggccgtaacg tcactgaccc aacatgccct tccctgagtc ctggcgtatc     3240

tcaatgcttc ccagactgtg tatgtgaaga tgcttataac aatacctatg cctgtgtgag     3300

gacaatgtca gcattgtgga atttgcagta ttgcgagttt gatgaccagg aggtgtttgt     3360

agaagtctat aatctgactg cagacccaga ccagatcact aacattgcta aaaccataga     3420

cccagagctt ttaggaaaga tgaactatcg gttaatgatg ttacagtcct gttctgggcc     3480

aacctgtcgc actccagggg tttttgaccc cggatacagg tttgaccccc gtctcatgtt     3540

cagcaatcgc ggcagtgtca ggactcgaag attttccaaa catcttctgt aggaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4313


<210>  10
<211>  4313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGNS-version1

<400>  10
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgagac tgctgcctct ggctcctggc cggctgagaa gaggcagccc     1980

tagacatctg cccagctgct ctccagccct gctgctgctg gtgctgggag gatgcctggg     2040

agtgtttgga gtggccgctg gcaccagacg gcccaatgtg gtgctgctgc tgaccgacga     2100

ccaggacgaa gtgctgggcg gcatgacccc cctgaaaaag accaaggccc tgatcggcga     2160

gatgggcatg accttcagca gcgcctatgt gcccagcgcc ctgtgctgtc ctagcagagc     2220

cagcatcctg accggcaagt acccccacaa ccaccatgtc gtgaacaaca ccctggaagg     2280

caactgcagc agcaagagct ggcagaagat ccaggaaccc aacaccttcc ccgccatcct     2340

gagatccatg tgcggctacc agaccttctt cgccggaaag tacctgaacg agtacggcgc     2400

tcctgacgct ggcggactgg aacatgtgcc tctgggctgg tcctattggt acgccctgga     2460

aaagaacagc aagtactaca actacaccct gagcatcaac ggcaaggccc ggaagcacgg     2520

cgagaactac agcgtggact acctgaccga tgtgctggcc aacgtgtccc tggacttcct     2580

ggactacaag agcaacttcg agcccttctt catgatgatc gccacccctg ccccccacag     2640

cccttggaca gctgctcctc agtaccagaa agccttccag aacgtgttcg cccccagaaa     2700

caagaacttc aacatccacg gcaccaacaa gcactggctg atccggcagg ccaagacccc     2760

catgaccaac agcagcatcc agtttctgga caacgccttc agaaagcggt ggcagaccct     2820

gctgtccgtg gacgacctgg tggaaaagct cgtgaagcgg ctggagttca ccggcgagct     2880

gaacaatacc tacatcttct acaccagcga caacggctac cacaccggcc agttcagcct     2940

gcccatcgac aagcggcagc tgtacgagtt cgacatcaag gtgcccctgc tcgtgcgggg     3000

acctggcatc aagcctaacc agacctccaa gatgctggtg gccaacatcg acctgggccc     3060

caccatcctg gatatcgccg gctacgacct gaacaagacc cagatggacg gcatgtccct     3120

gctgcctatc ctgagaggcg ccagcaatct gacatggcgg agcgacgtgc tggtggaata     3180

tcagggcgag ggccggaacg tgaccgaccc tacatgtcct agcctgagcc ctggcgtgtc     3240

ccagtgcttc cctgattgcg tgtgcgagga cgcctacaac aacacctacg cctgcgtgcg     3300

gaccatgtcc gccctgtgga acctgcagta ttgcgagttc gatgaccagg aagtgttcgt     3360

ggaagtgtac aacctgaccg ccgaccccga ccagatcacc aatatcgcca agaccatcga     3420

ccccgagctg ctgggaaaga tgaactaccg gctgatgatg ctgcagagct gcagcggccc     3480

tacctgcaga acaccaggcg tgttcgaccc cggctacaga ttcgacccca gactgatgtt     3540

cagcaaccgg ggctccgtgc gcaccagaag attcagcaaa catctgctct gagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4313


<210>  11
<211>  4313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGNS-version2

<400>  11
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgaggc tgctgcccct ggcccccgga aggttgcggc ggggttcgcc     1980

tagacacctc ccttcatgct ctcccgccct gttgctgctc gtgctcggcg gatgcctcgg     2040

ggtgttcggg gtggccgcgg gcacccggcg cccgaacgtc gtgctgctgc tgaccgacga     2100

ccaagacgag gtgctcggtg gcatgacccc gctgaagaaa accaaggcgc tgatcggtga     2160

aatgggcatg accttctcct ccgcatacgt gccctcggcc ctttgctgtc cgtcccgcgc     2220

gtccatcctg accgggaagt acccgcataa tcaccacgtc gtgaacaaca ctctcgaggg     2280

gaactgcagc tccaagtcct ggcagaagat ccaagagccc aataccttcc ctgctatcct     2340

gcggtcgatg tgcggatacc agaccttctt tgccggaaag tatctgaacg aatacggagc     2400

accagatgcc ggtggactgg aacatgtgcc gctgggatgg agctattggt acgcactgga     2460

gaagaactcc aagtactaca attacaccct gtccatcaac gggaaggccc gcaagcacgg     2520

cgaaaactat tccgtggact acctcaccga cgtgctggcc aacgtgtcgc tggatttcct     2580

tgactacaag tccaactttg agcccttctt catgatgatc gccactccgg cgccccatag     2640

cccctggacc gccgcgcctc agtaccaaaa ggctttccag aacgtgttcg ccccaagaaa     2700

caagaacttc aatattcacg gaactaacaa gcactggctg atcagacagg ccaaaactcc     2760

aatgaccaac tcgagcatcc agttcctgga caacgccttc cggaagcgct ggcagaccct     2820

gctctccgtg gatgacctgg tggaaaagct ggtcaagcgg ctggagttca ctggggagtt     2880

gaacaacacc tatatcttct acacctccga caatggttac cacaccggac agttctcgct     2940

gccaattgac aagcggcagc tgtacgagtt cgatattaag gtcccacttc ttgtgcgcgg     3000

gccgggaatc aagcccaacc aaacttccaa gatgctggtc gccaacattg acctgggtcc     3060

gactattctc gatatcgccg gctacgacct gaacaagact cagatggacg gcatgagctt     3120

gctgccgatc ctgcgcggag cgtccaacct gacttggagg tccgacgtct tggtggaata     3180

ccagggcgaa gggcgcaacg tcaccgaccc aacttgccct tcactgtcac ccggagtgtc     3240

ccagtgcttc cccgactgcg tgtgtgaaga tgcctacaac aatacctacg cctgcgtgcg     3300

caccatgtcc gctctctgga acctccagta ctgcgaattt gacgaccagg aggtgttcgt     3360

ggaagtgtac aacctgacag ccgatcctga ccaaatcacc aacattgcaa agaccatcga     3420

ccctgagctg ctgggaaaga tgaactacag gctgatgatg ctccagagct gctccggccc     3480

gacgtgccgg acgccgggag tgtttgaccc tggataccgg ttcgacccga gactgatgtt     3540

ctcaaaccgg ggctcggtcc ggacccgaag attcagcaaa cacctcctct gagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4313


<210>  12
<211>  4313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohGNS-version3

<400>  12
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcgac tgctgccact ggctcctgga agactgagac gagggtcacc     1980

aagacatctg cctagttgtt cacctgctct gctgctgctg gtgctgggcg gctgcctggg     2040

cgtgttcgga gtggcagcag gaacccggcg gcccaacgtg gtgctgctgc tgacagacga     2100

tcaggacgag gtgctgggag gaatgacccc cctgaagaag acaaaggccc tgatcggcga     2160

gatgggcatg acctttagct ccgcctacgt gcctagcgcc ctgtgctgtc caagccgggc     2220

ctctatcctg accggcaagt atccacacaa tcaccacgtg gtgaacaata cactggaggg     2280

caactgctct agcaagtctt ggcagaagat ccaggagcct aataccttcc cagccatcct     2340

gagaagcatg tgcggctacc agacattctt tgccggcaag tacctgaacg agtatggcgc     2400

cccagatgca ggaggcctgg agcacgtgcc actgggatgg agctactggt atgccctgga     2460

gaagaacagc aagtactata actacacact gagcatcaat ggcaaggcca ggaagcacgg     2520

cgagaactac tccgtggact atctgaccga tgtgctggcc aacgtgagcc tggacttcct     2580

ggattacaag tctaactttg agcccttctt tatgatgatc gcaaccccag cacctcacag     2640

cccatggaca gccgcccccc agtatcagaa ggccttccag aacgtgttcg cccctcggaa     2700

caagaacttc aacatccacg gcaccaacaa gcactggctg atcagacagg ccaagacccc     2760

aatgacaaat tcctctatcc agttcctgga caacgccttt aggaagcggt ggcagaccct     2820

gctgtccgtg gacgatctgg tggagaagct ggtgaagaga ctggagttca caggcgagct     2880

gaacaacacc tacatctttt atacaagcga taacggctac cacaccggcc agttctccct     2940

gcccatcgac aagaggcagc tgtatgagtt tgatatcaag gtgcctctgc tggtgcgcgg     3000

ccccggcatc aagcctaatc agacatctaa gatgctggtg gccaacatcg acctgggacc     3060

aaccatcctg gacatcgcag gctacgatct gaacaagaca cagatggatg gcatgtccct     3120

gctgcctatc ctgaggggag caagcaatct gacctggcgc tccgacgtgc tggtggagta     3180

tcagggcgag ggcaggaacg tgaccgatcc aacatgccca agcctgtccc ccggcgtgtc     3240

ccagtgtttc cctgactgcg tgtgcgagga tgcctacaac aatacctatg cctgcgtgcg     3300

cacaatgtct gccctgtgga atctgcagta ctgtgagttc gacgatcagg aggtgtttgt     3360

ggaggtgtat aatctgaccg ccgaccctga tcagatcacc aacatcgcca agacaatcga     3420

cccagagctg ctgggcaaga tgaactaccg gctgatgatg ctgcagtctt gcagcggccc     3480

tacctgtaga acaccaggcg tgttcgaccc cggctatcgg tttgatccta gactgatgtt     3540

ttccaataga ggctccgtga ggactcggcg gtttagtaag cacctgctgt aagaattcga     3600

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     3660

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     3720

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3780

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     3840

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     3900

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     3960

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     4020

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     4080

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     4140

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     4200

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4260

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4313


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GNS sense primer

<400>  13
ccacacaggg cagttctctt                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GNS antisense primer

<400>  14
gtgggaccca agtcgatgtt                                                   20


<210>  15
<211>  646
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  15
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgg                     646


<210>  16
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  omGNS

<400>  16
atgagactgc ctagcgccgc tggccccaga cccggcagac ctagaaggct gcctgccctg       60

ctgctgctgc ctctcctggg cggatgtctg ggccttgtgg gagccgctag aaggcccaac      120

gtgctgctgc tgctgacaga cgaccaggat gccgagctgg gcggcatgac ccccctgaaa      180

aagaccaagg ccctgatcgg cgagaagggc atgaccttca gcagcgccta cgtgcccagc      240

gccctgtgct gtcccagcag agccagcatc ctgaccggca agtaccccca caaccaccac      300

gtggtgaaca acaccctgga aggcaactgc agcagcaagg cctggcagaa gatccaagaa      360

ccctacacct tccccgccat cctgaagtcc gtgtgcggct accagacctt cttcgctggc      420

aagtacctga acgagtacgg cgctcccgac gctggcggcc tggaacatat ccccctgggc      480

tggtcctatt ggtacgccct ggaaaagaac agcaagtact acaactacac cctgagcatc      540

aacggcaagg ccagaaagca cggcgagaac tacagcgtgg actacctgac cgacgtgctg      600

gccaacctga gcctggactt cctggactac aagagcaaca gcgagccatt cttcatgatg      660

atcagcaccc ctgcccccca cagcccttgg acagccgccc ctcagtacca gaaagccttc      720

cagaacgtga tcgcccccag aaacaagaac ttcaacatcc acggcaccaa caagcactgg      780

ctgatcagac aggccaagac ccccatgacc aacagctcta tcagattcct ggacgacgcc      840

ttcaggcgga gatggcagac cctgctgtcc gtggacgacc tggtggaaaa gctggtgaaa      900

agactggaca gcaccggcga gctggacaac acctacatct tctacaccag cgacaacggc      960

taccacaccg gccagttcag cctgcccatc gacaagagac agctgtacga gttcgacatc     1020

aaggtgcccc tgctcgtgcg cggacccggc atcaagccca accagaccag caagatgctg     1080

gtgtccaaca tcgacctggg ccccaccatc ctggacctgg ccggctacga cctgaacaag     1140

acccagatgg acggcatgag cctgctgcct atcctgaagg gcgacagaaa cctgacctgg     1200

cgctctgacg tgctggtgga ataccagggc gagggcagaa acgtgaccga ccctacctgc     1260

cccagcctgt ctcctggcgt gtcccagtgc ttccccgact gtgtgtgcga ggacgcctac     1320

aacaacacat acgcctgcgt gcggaccctg agcagcctgt ggaacctgca gtactgcgag     1380

ttcgatgacc aagaagtgtt cgtcgaagtc tacaacatca ccgccgaccc cgaccagatc     1440

accaatatcg ccaagagcat cgaccccgag ctgctgggca agatgaacta cagactgatg     1500

atgctgcaga gctgcagcgg ccctacctgc agaacccctg gcgtgttcga ccccggctac     1560

agattcgacc tgagactgat gttcaactcc cacggcagcg tgcgcaccag aagattcagc     1620

aagcaccccc tgtga                                                      1635


<210>  17
<211>  7887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-omGNS

<400>  17
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgct agcgccacca tgagactgcc tagcgccgct ggccccagac ccggcagacc     1980

tagaaggctg cctgccctgc tgctgctgcc tctcctgggc ggatgtctgg gccttgtggg     2040

agccgctaga aggcccaacg tgctgctgct gctgacagac gaccaggatg ccgagctggg     2100

cggcatgacc cccctgaaaa agaccaaggc cctgatcggc gagaagggca tgaccttcag     2160

cagcgcctac gtgcccagcg ccctgtgctg tcccagcaga gccagcatcc tgaccggcaa     2220

gtacccccac aaccaccacg tggtgaacaa caccctggaa ggcaactgca gcagcaaggc     2280

ctggcagaag atccaagaac cctacacctt ccccgccatc ctgaagtccg tgtgcggcta     2340

ccagaccttc ttcgctggca agtacctgaa cgagtacggc gctcccgacg ctggcggcct     2400

ggaacatatc cccctgggct ggtcctattg gtacgccctg gaaaagaaca gcaagtacta     2460

caactacacc ctgagcatca acggcaaggc cagaaagcac ggcgagaact acagcgtgga     2520

ctacctgacc gacgtgctgg ccaacctgag cctggacttc ctggactaca agagcaacag     2580

cgagccattc ttcatgatga tcagcacccc tgccccccac agcccttgga cagccgcccc     2640

tcagtaccag aaagccttcc agaacgtgat cgcccccaga aacaagaact tcaacatcca     2700

cggcaccaac aagcactggc tgatcagaca ggccaagacc cccatgacca acagctctat     2760

cagattcctg gacgacgcct tcaggcggag atggcagacc ctgctgtccg tggacgacct     2820

ggtggaaaag ctggtgaaaa gactggacag caccggcgag ctggacaaca cctacatctt     2880

ctacaccagc gacaacggct accacaccgg ccagttcagc ctgcccatcg acaagagaca     2940

gctgtacgag ttcgacatca aggtgcccct gctcgtgcgc ggacccggca tcaagcccaa     3000

ccagaccagc aagatgctgg tgtccaacat cgacctgggc cccaccatcc tggacctggc     3060

cggctacgac ctgaacaaga cccagatgga cggcatgagc ctgctgccta tcctgaaggg     3120

cgacagaaac ctgacctggc gctctgacgt gctggtggaa taccagggcg agggcagaaa     3180

cgtgaccgac cctacctgcc ccagcctgtc tcctggcgtg tcccagtgct tccccgactg     3240

tgtgtgcgag gacgcctaca acaacacata cgcctgcgtg cggaccctga gcagcctgtg     3300

gaacctgcag tactgcgagt tcgatgacca agaagtgttc gtcgaagtct acaacatcac     3360

cgccgacccc gaccagatca ccaatatcgc caagagcatc gaccccgagc tgctgggcaa     3420

gatgaactac agactgatga tgctgcagag ctgcagcggc cctacctgca gaacccctgg     3480

cgtgttcgac cccggctaca gattcgacct gagactgatg ttcaactccc acggcagcgt     3540

gcgcaccaga agattcagca agcaccccct gtgatgagcg gccgcgaatt cgagctcggt     3600

acccgggaat caattcactc ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt     3660

ggccaatgcc ctggctcaca aataccactg agatcttttt ccctctgcca aaaattatgg     3720

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     3780

tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga aggacatatg ggagggcaaa     3840

tcatttaaaa catcagaatg agtatttggt ttagagtttg gcaacatatg cccatatgct     3900

ggctgccatg aacaaaggtt ggctataaag aggtcatcag tatatgaaac agccccctgc     3960

tgtccattcc ttattccata gaaaagcctt gacttgaggt tagatttttt ttatattttg     4020

ttttgtgtta tttttttctt taacatccct aaaattttcc ttacatgttt tactagccag     4080

atttttcctc ctctcctgac tactcccagt catagctgtc cctcttctct tatggagatc     4140

cctcgacctg cagcccaagc tgtagataag tagcatggcg ggttaatcat taactacaag     4200

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     4260

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc attaatgaat     4320

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     4380

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     4440

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     4500

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     4560

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     4620

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     4680

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     4740

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     4800

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     4860

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     4920

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     4980

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     5040

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     5100

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     5160

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     5220

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     5280

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     5340

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     5400

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     5460

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     5520

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     5580

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     5640

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     5700

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     5760

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     5820

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     5880

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     5940

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     6000

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     6060

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     6120

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     6180

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     6240

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta     6300

agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg     6360

tctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt     6420

cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg     6480

tgttggcggg tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt     6540

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     6600

attccaacat ccaataaatc atacaggcaa ggcaaagaat tagcaaaatt aagcaataaa     6660

gcctcagagc ataaagctaa atcggttgta ccaaaaacat tatgaccctg taatactttt     6720

gcgggagaag cctttatttc aacgcaagga taaaaatttt tagaaccctc atatatttta     6780

aatgcaatgc ctgagtaatg tgtaggtaaa gattcaaacg ggtgagaaag gccggagaca     6840

gtcaaatcac catcaatatg atattcaacc gttctagctg ataaattcat gccggagagg     6900

gtagctattt ttgagaggtc tctacaaagg ctatcaggtc attgcctgag agtctggagc     6960

aaacaagaga atcgatgaac ggtaatcgta aaactagcat gtcaatcata tgtaccccgg     7020

ttgataatca gaaaagcccc aaaaacagga agattgtata agcaaatatt taaattgtaa     7080

gcgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc     7140

aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga     7200

gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag     7260

ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt     7320

ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta     7380

gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag     7440

cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg     7500

cgcttaatgc gccgctacag ggcgcgtact atggttgctt tgacgagcac gtataacgtg     7560

ctttcctcgt tagaatcaga gcgggagcta aacaggaggc cgattaaagg gattttagac     7620

aggaacggta cgccagaatc ctgagaagtg tttttataat cagtgaggcc accgagtaaa     7680

agagtctgtc catcacgcaa attaaccgtt gtcgcaatac ttctttgatt agtaataaca     7740

tcacttgcct gagtagaaga actcaaacta tcggccttgc tggtaatatc cagaacaata     7800

ttaccgccag ccattgcaac ggaatcgcca ttcgccattc aggctgcgca actgttggga     7860

agggcgatcg gtgcgggcct cttcgct                                         7887


<210>  18
<211>  4306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-omGNS

<400>  18
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgct agcgccacca tgagactgcc tagcgccgct ggccccagac ccggcagacc     1980

tagaaggctg cctgccctgc tgctgctgcc tctcctgggc ggatgtctgg gccttgtggg     2040

agccgctaga aggcccaacg tgctgctgct gctgacagac gaccaggatg ccgagctggg     2100

cggcatgacc cccctgaaaa agaccaaggc cctgatcggc gagaagggca tgaccttcag     2160

cagcgcctac gtgcccagcg ccctgtgctg tcccagcaga gccagcatcc tgaccggcaa     2220

gtacccccac aaccaccacg tggtgaacaa caccctggaa ggcaactgca gcagcaaggc     2280

ctggcagaag atccaagaac cctacacctt ccccgccatc ctgaagtccg tgtgcggcta     2340

ccagaccttc ttcgctggca agtacctgaa cgagtacggc gctcccgacg ctggcggcct     2400

ggaacatatc cccctgggct ggtcctattg gtacgccctg gaaaagaaca gcaagtacta     2460

caactacacc ctgagcatca acggcaaggc cagaaagcac ggcgagaact acagcgtgga     2520

ctacctgacc gacgtgctgg ccaacctgag cctggacttc ctggactaca agagcaacag     2580

cgagccattc ttcatgatga tcagcacccc tgccccccac agcccttgga cagccgcccc     2640

tcagtaccag aaagccttcc agaacgtgat cgcccccaga aacaagaact tcaacatcca     2700

cggcaccaac aagcactggc tgatcagaca ggccaagacc cccatgacca acagctctat     2760

cagattcctg gacgacgcct tcaggcggag atggcagacc ctgctgtccg tggacgacct     2820

ggtggaaaag ctggtgaaaa gactggacag caccggcgag ctggacaaca cctacatctt     2880

ctacaccagc gacaacggct accacaccgg ccagttcagc ctgcccatcg acaagagaca     2940

gctgtacgag ttcgacatca aggtgcccct gctcgtgcgc ggacccggca tcaagcccaa     3000

ccagaccagc aagatgctgg tgtccaacat cgacctgggc cccaccatcc tggacctggc     3060

cggctacgac ctgaacaaga cccagatgga cggcatgagc ctgctgccta tcctgaaggg     3120

cgacagaaac ctgacctggc gctctgacgt gctggtggaa taccagggcg agggcagaaa     3180

cgtgaccgac cctacctgcc ccagcctgtc tcctggcgtg tcccagtgct tccccgactg     3240

tgtgtgcgag gacgcctaca acaacacata cgcctgcgtg cggaccctga gcagcctgtg     3300

gaacctgcag tactgcgagt tcgatgacca agaagtgttc gtcgaagtct acaacatcac     3360

cgccgacccc gaccagatca ccaatatcgc caagagcatc gaccccgagc tgctgggcaa     3420

gatgaactac agactgatga tgctgcagag ctgcagcggc cctacctgca gaacccctgg     3480

cgtgttcgac cccggctaca gattcgacct gagactgatg ttcaactccc acggcagcgt     3540

gcgcaccaga agattcagca agcaccccct gtgatgagcg gccgcgaatt cgagctcggt     3600

acccgggaat caattcactc ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt     3660

ggccaatgcc ctggctcaca aataccactg agatcttttt ccctctgcca aaaattatgg     3720

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     3780

tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga aggacatatg ggagggcaaa     3840

tcatttaaaa catcagaatg agtatttggt ttagagtttg gcaacatatg cccatatgct     3900

ggctgccatg aacaaaggtt ggctataaag aggtcatcag tatatgaaac agccccctgc     3960

tgtccattcc ttattccata gaaaagcctt gacttgaggt tagatttttt ttatattttg     4020

ttttgtgtta tttttttctt taacatccct aaaattttcc ttacatgttt tactagccag     4080

atttttcctc ctctcctgac tactcccagt catagctgtc cctcttctct tatggagatc     4140

cctcgacctg cagcccaagc tgtagataag tagcatggcg ggttaatcat taactacaag     4200

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     4260

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag                    4306


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGNS sense primer

<400>  19
aaactggtca agaggctgga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hGNS antisense primer

<400>  20
tggtttgatc ccaggtcctc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v1 sense primer

<400>  21
ccaacagcag catccagttt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v1 antisense primer

<400>  22
cgttgtcgct ggtgtagaag                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v2  sense primer

<400>  23
ctgaagaaaa ccaaggcgct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v2 antisense primer

<400>  24
agttcccctc gagagtgttg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v3 sense primer

<400>  25
aacttcaaca tccacggcac                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohGNS-v3 antisense primer

<400>  26
actccagtct cttcaccagc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human RPLPP0 sense primer

<400>  27
ctctggagaa actgctgcct                                                   20


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human RPLPP0 antisense primer

<400>  28
ctgcacatca ctcaggattt caa                                               23


