                         SEQUENCE LISTING

<110>  Macfarlane Burnet Institute for Medical Research and Public
        Health Limited
 
<120>  Assembled glycoproteins

<130>  526133

<141>  2017-09-22

<150>  2016903961
<151>  2016-09-29

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified viral sequence

<400>  1
ggtaccgcta gcgccaccat gaaccccctg ctgatcctga cctttgtggc cgctgccctg       60

gccgagacac accagaacat ccagctgatc aacaccaacg gcagctggca catcaacagc      120

accgccctga actgcaacga gagcctgaac acaggctggc tggccggcct gttctaccag      180

cacaagttca acagcagcgg agcccccgag agactggcct cttgtggatc ttctggcgcc      240

tggcactacc cccctagacc ttgtggaatc gtgcccgcca agagcgtgtg cggccctgtg      300

tactgcttca cccctagccc tgtggtcgtg ggcaccaccg atagatctgg cgcccctacc      360

tattcctggg gcgccaacga caccgacgtg ttcgtgctga acaacacccg gccacccctg      420

ggcaattggt tcggctgcac ctggatgaac tccaccggct tcaccaaagt gtgcggcgct      480

cctcctgccg gatccagcgg agcacctacc gacgccttca gaaagcaccc cgaggccacc      540

tactctagag ccggatctgg cccctggatc acccccagat gcatggtgga ctacccctac      600

cggctgtggc actatccctg caccatcaac tacaccatct tcaaagtgcg gatgtacgtg      660

ggcggcgtgg aacacagact ggaagccgcc tgcaactgga ccagaggcga gagagccgac      720

ctggaagatc gggacagaag cgagcaccac caccatcacc actgatgact cgag            774


<210>  2
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified viral sequence

<400>  2
atgaaccccc tgctgatcct gacctttgtg gccgctgccc tggccgagac acaccagaac       60

atccagctga tcaacaccaa cggcagctgg cacatcaaca gcaccgccct gaactgcaac      120

gagagcctga acacaggctg gctggccggc ctgttctacc agcacaagtt caacagcagc      180

ggagcccccg agagactggc ctcttgtgga tcttctggcg cctggcacta cccccctaga      240

ccttgtggaa tcgtgcccgc caagagcgtg tgcggccctg tgtactgctt cacccctagc      300

cctgtggtcg tgggcaccac cgatagatct ggcgccccta cctattcctg gggcgccaac      360

gacaccgacg tgttcgtgct gaacaacacc cggccacccc tgggcaattg gttcggctgc      420

acctggatga actccaccgg cttcaccaaa gtgtgcggcg ctcctcctgc cggatccagc      480

ggagcaccta ccgacgcctt cagaaagcac cccgaggcca cctactctag agccggatct      540

ggcccctgga tcacccccag atgcatggtg gactacccct accggctgtg gcactatccc      600

tgcaccatca actacaccat cttcaaagtg cggatgtacg tgggcggcgt ggaacacaga      660

ctggaagccg cctgcaactg gaccagaggc gagagagccg acctggaaga tcgggacaga      720

agcgagcacc accaccatca ccactga                                          747


<210>  3
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified viral sequence

<400>  3

Glu Thr His Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10                  15      


Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp 
            20                  25                  30          


Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Ala Pro 
        35                  40                  45              


Glu Arg Leu Ala Ser Cys Gly Ser Ser Gly Ala Trp His Tyr Pro Pro 
    50                  55                  60                  


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
65                  70                  75                  80  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
                85                  90                  95      


Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu 
            100                 105                 110         


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
        115                 120                 125             


Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Ala Gly Ser 
    130                 135                 140                 


Ser Gly Ala Pro Thr Asp Ala Phe Arg Lys His Pro Glu Ala Thr Tyr 
145                 150                 155                 160 


Ser Arg Ala Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met Val Asp 
                165                 170                 175     


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr Ile 
            180                 185                 190         


Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala 
        195                 200                 205             


Ala Cys Asn Trp Thr Arg Gly Glu Arg Ala Asp Leu Glu Asp Arg Asp 
    210                 215                 220                 


Arg Ser Glu 
225         


<210>  4
<211>  278
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Glu Thr His Val Thr Gly Gly Asn Ala Gly Arg Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr 
65                  70                  75                  80  


Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn 
225                 230                 235                 240 


Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu 
        275             


<210>  5
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified E2

<400>  5

Glu Thr His Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10                  15      


Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp 
            20                  25                  30          


Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Cys Pro 
        35                  40                  45              


Glu Arg Leu Ala Ser Cys Gly Ser Ser Gly Cys Trp His Tyr Pro Pro 
    50                  55                  60                  


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
65                  70                  75                  80  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
                85                  90                  95      


Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu 
            100                 105                 110         


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
        115                 120                 125             


Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Gly Ser 
    130                 135                 140                 


Ser Gly Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
145                 150                 155                 160 


Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met Val Asp 
                165                 170                 175     


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr Ile 
            180                 185                 190         


Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala 
        195                 200                 205             


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp 
    210                 215                 220                 


Arg Ser Glu 
225         


<210>  6
<211>  3011
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Ile Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Phe Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Met Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ile Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Ile 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Gln 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Thr Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ser Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Ser His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ser Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Gln Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Thr Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Val Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Gly Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Arg Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Lys Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Arg  Val Gly Asp Phe His  Tyr Val Ser 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Ile Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Arg 
    2270                 2275                 2280             


Ala Leu  Pro Val Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Arg  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Leu  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Val Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Gly Ala Asp Thr Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Ala His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asn Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  7
<211>  363
<212>  PRT
<213>  Hepatitis C virus

<400>  7

Glu Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr 
65                  70                  75                  80  


Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn 
225                 230                 235                 240 


Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
        355                 360             


<210>  8
<211>  278
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Glu Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr 
65                  70                  75                  80  


Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn 
225                 230                 235                 240 


Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu 
        275             


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-Terminal signal sequence

<400>  9

Met Asn Pro Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Leu Ala 
1               5                   10                  15  


<210>  10
<211>  353
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Tyr Phe Ser Met Gln Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe 
1               5                   10                  15      


Leu Phe Ala Gly Val Asp Ala Glu Thr His Val Ser Gly Ala Ala Val 
            20                  25                  30          


Gly Arg Ser Thr Ala Gly Leu Ala Asn Leu Phe Ser Ser Gly Ser Lys 
        35                  40                  45              


Gln Asn Leu Gln Leu Ile Asn Ser Asn Gly Ser Trp His Ile Asn Arg 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly Phe Leu Ala Ser 
65                  70                  75                  80  


Leu Phe Tyr Thr His Lys Phe Asn Ser Ser Gly Cys Ser Glu Arg Leu 
                85                  90                  95      


Ala Cys Cys Lys Ser Leu Asp Ser Tyr Gly Gln Gly Trp Gly Pro Leu 
            100                 105                 110         


Gly Val Ala Asn Ile Ser Gly Ser Ser Asp Asp Arg Pro Tyr Cys Trp 
        115                 120                 125             


His Tyr Ala Pro Arg Pro Cys Gly Ile Val Pro Ala Ser Ser Val Cys 
    130                 135                 140                 


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
145                 150                 155                 160 


Asp His Val Gly Val Pro Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp 
                165                 170                 175     


Val Phe Leu Leu Asn Ser Thr Arg Pro Pro His Gly Ala Trp Phe Gly 
            180                 185                 190         


Cys Val Trp Met Asn Ser Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro 
        195                 200                 205             


Pro Cys Glu Val Asn Thr Asn Asn Gly Thr Trp His Cys Pro Thr Asp 
    210                 215                 220                 


Cys Phe Arg Lys His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly 
225                 230                 235                 240 


Pro Trp Ile Thr Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp 
                245                 250                 255     


His Phe Pro Cys Thr Ala Asn Phe Ser Val Phe Asn Ile Arg Thr Phe 
            260                 265                 270         


Val Gly Gly Ile Glu His Arg Met Gln Ala Ala Cys Asn Trp Thr Arg 
        275                 280                 285             


Gly Glu Val Cys Gly Leu Glu His Arg Asp Arg Val Glu Leu Ser Pro 
    290                 295                 300                 


Leu Leu Leu Thr Thr Thr Ala Trp Gln Ile Leu Pro Cys Ser Phe Thr 
305                 310                 315                 320 


Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
                325                 330                 335     


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp 
            340                 345                 350         


Ala 
    


<210>  11
<211>  353
<212>  PRT
<213>  Hepatitis C virus

<400>  11

Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu 
1               5                   10                  15      


Leu Phe Ala Gly Val Asp Ala Glu Thr His Val Thr Gly Gly Asn Ala 
            20                  25                  30          


Gly Arg Thr Thr Ala Gly Leu Val Gly Leu Leu Thr Pro Gly Ala Lys 
        35                  40                  45              


Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Ser 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp Leu Ala Gly 
65                  70                  75                  80  


Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu 
                85                  90                  95      


Ala Ser Cys Arg Arg Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile 
            100                 105                 110         


Ser Tyr Ala Asn Gly Ser Gly Leu Asp Glu Arg Pro Tyr Cys Trp His 
        115                 120                 125             


Tyr Pro Pro Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly 
    130                 135                 140                 


Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp 
145                 150                 155                 160 


Arg Ser Gly Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val 
                165                 170                 175     


Phe Val Leu Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys 
            180                 185                 190         


Thr Trp Met Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro 
        195                 200                 205             


Cys Val Ile Gly Gly Val Gly Asn Asn Thr Leu Leu Cys Pro Thr Asp 
    210                 215                 220                 


Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly 
225                 230                 235                 240 


Pro Trp Ile Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp 
                245                 250                 255     


His Tyr Pro Cys Thr Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr 
            260                 265                 270         


Val Gly Gly Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp Thr Arg 
        275                 280                 285             


Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro 
    290                 295                 300                 


Leu Leu Leu Ser Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr 
305                 310                 315                 320 


Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
                325                 330                 335     


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp 
            340                 345                 350         


Ala 
    


<210>  12
<211>  354
<212>  PRT
<213>  Hepatitis C virus

<400>  12

Tyr Tyr Ala Ser Ala Ala Asn Trp Ala Lys Val Val Leu Val Leu Phe 
1               5                   10                  15      


Leu Phe Ala Gly Val Asp Ala Asn Thr Arg Thr Val Gly Gly Ser Ala 
            20                  25                  30          


Ala Gln Gly Ala Arg Gly Leu Ala Ser Leu Phe Thr Pro Gly Pro Gln 
        35                  40                  45              


Gln Asn Leu Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Val Ala Gly 
65                  70                  75                  80  


Leu Leu Tyr Tyr His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Met 
                85                  90                  95      


Ala Ser Cys Arg Pro Leu Ala Ala Phe Asp Gln Gly Trp Gly Thr Ile 
            100                 105                 110         


Ser Tyr Ala Ala Val Ser Gly Pro Ser Asp Asp Lys Pro Tyr Cys Trp 
        115                 120                 125             


His Tyr Pro Pro Arg Pro Cys Gly Ile Val Pro Ala Arg Gly Val Cys 
    130                 135                 140                 


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
145                 150                 155                 160 


Asp Arg Lys Gly Asn Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp 
                165                 170                 175     


Ile Phe Leu Leu Asn Asn Thr Arg Pro Pro Thr Gly Asn Trp Phe Gly 
            180                 185                 190         


Cys Thr Trp Met Asn Ser Thr Gly Phe Val Lys Thr Cys Gly Ala Pro 
        195                 200                 205             


Pro Cys Asn Leu Gly Pro Thr Gly Asn Asn Ser Leu Lys Cys Pro Thr 
    210                 215                 220                 


Asp Cys Phe Arg Lys His Pro Asp Ala Thr Tyr Thr Lys Cys Gly Ser 
225                 230                 235                 240 


Gly Pro Trp Leu Thr Pro Arg Cys Leu Val His Tyr Pro Tyr Arg Leu 
                245                 250                 255     


Trp His Tyr Pro Cys Thr Leu Asn Tyr Thr Ile Phe Lys Val Arg Met 
            260                 265                 270         


Tyr Ile Gly Gly Leu Glu His Arg Leu Glu Val Ala Cys Asn Trp Thr 
        275                 280                 285             


Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ala Glu Leu Ser 
    290                 295                 300                 


Pro Leu Leu His Thr Thr Thr Gln Trp Ala Ile Leu Pro Cys Ser Phe 
305                 310                 315                 320 


Thr Pro Thr Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn 
                325                 330                 335     


Ile Val Asp Thr Gln Tyr Leu Tyr Gly Leu Ser Ser Ser Ile Val Ser 
            340                 345                 350         


Trp Ala 
        


<210>  13
<211>  359
<212>  PRT
<213>  Hepatitis C virus

<400>  13

Tyr Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Ala Ile Val Met Ile 
1               5                   10                  15      


Met Phe Ser Gly Val Asp Ala Glu Thr Tyr Val Thr Gly Gly Ser Val 
            20                  25                  30          


Ala His Ser Ala Arg Gly Leu Thr Ser Leu Phe Ser Met Gly Ala Lys 
        35                  40                  45              


Gln Lys Leu Gln Leu Val Asn Thr Asn Gly Ser Trp His Ile Asn Ser 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Glu Ser Ile Asn Thr Gly Phe Ile Ala Gly 
65                  70                  75                  80  


Leu Phe Tyr Tyr His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Leu 
                85                  90                  95      


Ser Ser Cys Lys Pro Ile Ile Ser Phe Arg Gln Gly Trp Gly Pro Leu 
            100                 105                 110         


Thr Asp Ala Asn Ile Thr Gly Pro Ser Asp Asp Arg Pro Tyr Cys Trp 
        115                 120                 125             


His Tyr Ala Pro Arg Pro Cys Ser Val Val Pro Ala Ser Ser Val Cys 
    130                 135                 140                 


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
145                 150                 155                 160 


Asp Ile Lys Gly Arg Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp 
                165                 170                 175     


Val Phe Leu Leu Glu Ser Leu Arg Pro Pro Ser Gly Arg Trp Phe Gly 
            180                 185                 190         


Cys Ala Trp Met Asn Ser Thr Gly Phe Leu Lys Thr Cys Gly Ala Pro 
        195                 200                 205             


Pro Cys Asn Ile Tyr Gly Gly Glu Gly Asp Pro Glu Asn Glu Thr Asp 
    210                 215                 220                 


Leu Phe Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
225                 230                 235                 240 


Ser Arg Cys Gly Ala Gly Pro Trp Leu Thr Pro Arg Cys Met Val Asp 
                245                 250                 255     


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Leu 
            260                 265                 270         


Phe Lys Val Arg Met Phe Val Gly Gly Phe Glu His Arg Phe Thr Ala 
        275                 280                 285             


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Ile Glu Asp Arg Asp 
    290                 295                 300                 


Arg Ser Glu Gln His Pro Leu Leu His Ser Thr Thr Glu Leu Ala Ile 
305                 310                 315                 320 


Leu Pro Cys Ser Phe Thr Pro Met Pro Ala Leu Ser Thr Gly Leu Ile 
                325                 330                 335     


His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly 
            340                 345                 350         


Ser Asp Met Val Gly Trp Ala 
        355                 


<210>  14
<211>  357
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Tyr Phe Gly Met Ala Gly Asn Trp Leu Lys Val Leu Ala Val Leu Phe 
1               5                   10                  15      


Leu Phe Ala Gly Val Glu Ala Gln Thr Met Ile Ala His Gly Val Ser 
            20                  25                  30          


Gln Thr Thr Ser Gly Phe Ala Ser Leu Leu Thr Pro Gly Ala Lys Gln 
        35                  40                  45              


Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr 
    50                  55                  60                  


Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu 
65                  70                  75                  80  


Phe Tyr Thr His Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala 
                85                  90                  95      


Ala Cys Lys Pro Leu Ala Glu Phe Arg Gln Gly Trp Gly Gln Ile Thr 
            100                 105                 110         


His Lys Asn Val Ser Gly Pro Ser Asp Asp Arg Pro Tyr Cys Trp His 
        115                 120                 125             


Tyr Ala Pro Arg Pro Cys Glu Val Val Pro Ala Arg Ser Val Cys Gly 
    130                 135                 140                 


Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp 
145                 150                 155                 160 


Lys Arg Gly Asn Pro Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val 
                165                 170                 175     


Phe Met Leu Glu Ser Leu Arg Pro Pro Thr Gly Gly Trp Phe Gly Cys 
            180                 185                 190         


Thr Trp Met Asn Ser Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro 
        195                 200                 205             


Cys Gln Ile Val Pro Gly Asn Tyr Asn Ser Ser Ala Asn Glu Leu Leu 
    210                 215                 220                 


Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Gln Arg 
225                 230                 235                 240 


Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Cys Leu Val Asp Tyr Ala 
                245                 250                 255     


Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Leu His Lys 
            260                 265                 270         


Val Arg Met Phe Val Gly Gly Thr Glu His Arg Phe Asp Val Ala Cys 
        275                 280                 285             


Asn Trp Thr Arg Gly Glu Arg Cys Glu Leu His Asp Arg Asn Arg Ile 
    290                 295                 300                 


Glu Met Ser Pro Leu Leu Phe Ser Thr Thr Gln Leu Ser Ile Leu Pro 
305                 310                 315                 320 


Cys Ser Phe Ser Thr Met Pro Ala Leu Ser Thr Gly Leu Ile His Leu 
                325                 330                 335     


His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Ser Thr Asn 
            340                 345                 350         


Val Thr Ser Trp Val 
        355         


<210>  15
<211>  357
<212>  PRT
<213>  Hepatitis C virus

<400>  15

Tyr Phe Gly Met Ala Gly Asn Trp Ala Lys Val Ile Leu Ile Met Leu 
1               5                   10                  15      


Leu Met Ser Gly Val Asp Ala Glu Thr Met Ala Val Gly Ala Arg Ala 
            20                  25                  30          


Ala His Thr Thr Gly Ala Leu Val Ser Leu Leu Asn Pro Gly Pro Ser 
        35                  40                  45              


Gln Arg Leu Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Ile Ala Ala 
65                  70                  75                  80  


Leu Phe Tyr Thr His Arg Phe Asn Ser Ser Gly Cys Pro Glu Arg Met 
                85                  90                  95      


Ala Ser Cys Lys Pro Leu Ser Asp Phe Asp Gln Gly Trp Gly Pro Leu 
            100                 105                 110         


Trp Tyr Asn Ser Thr Glu Arg Pro Ser Asp Gln Arg Pro Tyr Cys Trp 
        115                 120                 125             


His Tyr Ala Pro Ser Pro Cys Gly Ile Val Pro Ala Lys Asp Val Cys 
    130                 135                 140                 


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
145                 150                 155                 160 


Asp Arg Arg Gly Val Pro Thr Tyr Thr Trp Gly Glu Asn Glu Ser Asp 
                165                 170                 175     


Val Phe Leu Leu Asn Ser Thr Arg Pro Pro Gln Gly Ser Trp Phe Gly 
            180                 185                 190         


Cys Ser Trp Met Asn Thr Thr Gly Phe Thr Lys Thr Cys Gly Gly Pro 
        195                 200                 205             


Pro Cys Lys Ile Arg Pro Gln Gly Ala Gln Ser Asn Thr Ser Leu Thr 
    210                 215                 220                 


Cys Pro Thr Asp Cys Phe Arg Lys His Pro Arg Ala Thr Tyr Ser Ala 
225                 230                 235                 240 


Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Met Val His Tyr Pro 
                245                 250                 255     


Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile His Lys 
            260                 265                 270         


Val Arg Leu Tyr Ile Gly Gly Val Glu His Arg Leu Asp Ala Ala Cys 
        275                 280                 285             


Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Val 
    290                 295                 300                 


Asp Met Ser Pro Leu Leu His Ser Thr Thr Glu Leu Ala Ile Leu Pro 
305                 310                 315                 320 


Cys Ser Phe Val Pro Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu 
                325                 330                 335     


His Gln Asn Ile Val Asp Ala Gln Tyr Leu Tyr Gly Leu Ser Pro Ala 
            340                 345                 350         


Ile Ile Ser Trp Ala 
        355         


<210>  16
<211>  357
<212>  PRT
<213>  Hepatitis C virus

<400>  16

Tyr Phe Ser Met Gln Gly Ala Trp Ala Lys Val Val Val Ile Leu Leu 
1               5                   10                  15      


Leu Ala Ala Gly Val Asp Ala Arg Thr His Thr Val Gly Gly Ser Ala 
            20                  25                  30          


Ala Gln Thr Thr Gly Arg Leu Thr Ser Leu Phe Asp Met Gly Pro Arg 
        35                  40                  45              


Gln Lys Ile Gln Leu Val Asn Thr Asn Gly Ser Trp His Ile Asn Arg 
    50                  55                  60                  


Thr Ala Leu Asn Cys Asn Asp Ser Leu His Thr Gly Phe Ile Ala Ser 
65                  70                  75                  80  


Leu Phe Tyr Thr His Ser Phe Asn Ser Ser Gly Cys Pro Glu Arg Met 
                85                  90                  95      


Ser Ala Cys Arg Ser Ile Glu Ala Phe Arg Val Gly Trp Gly Ala Leu 
            100                 105                 110         


Gln Tyr Glu Asp Asn Val Thr Asn Pro Glu Asp Met Arg Pro Tyr Cys 
        115                 120                 125             


Trp His Tyr Pro Pro Arg Gln Cys Gly Val Val Ser Ala Lys Thr Val 
    130                 135                 140                 


Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr 
145                 150                 155                 160 


Thr Asp Arg Leu Gly Ala Pro Thr Tyr Thr Trp Gly Glu Asn Glu Thr 
                165                 170                 175     


Asp Val Phe Leu Leu Asn Ser Thr Arg Pro Pro Leu Gly Ser Trp Phe 
            180                 185                 190         


Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr Thr Lys Thr Cys Gly Ala 
        195                 200                 205             


Pro Pro Cys Arg Thr Arg Ala Asp Phe Asn Ala Ser Thr Asp Leu Leu 
    210                 215                 220                 


Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Thr Thr Tyr Leu Lys 
225                 230                 235                 240 


Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Ile Asp Tyr Pro 
                245                 250                 255     


Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr Thr Ile Phe Lys 
            260                 265                 270         


Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Thr Ala Ala Cys 
        275                 280                 285             


Asn Phe Thr Arg Gly Asp Arg Cys Asn Leu Glu Asp Arg Asp Arg Ser 
    290                 295                 300                 


Gln Leu Ser Pro Leu Leu His Ser Thr Thr Glu Trp Ala Ile Leu Pro 
305                 310                 315                 320 


Cys Ser Tyr Ser Asp Leu Pro Ala Leu Ser Thr Gly Leu Leu His Leu 
                325                 330                 335     


His Gln Asn Ile Val Asp Val Gln Phe Met Tyr Gly Leu Ser Pro Ala 
            340                 345                 350         


Leu Thr Lys Tyr Ile 
        355         


<210>  17
<211>  632
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  17

Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
1               5                   10                  15      


Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr 
            20                  25                  30          


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        35                  40                  45              


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    50                  55                  60                  


Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu 
65                  70                  75                  80  


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                85                  90                  95      


Thr Leu Asn Cys Thr Asp Leu Arg Asn Val Thr Ser Ser Glu Gly Met 
            100                 105                 110         


Arg Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg 
        115                 120                 125             


Asp Lys Val Lys Lys Asp Tyr Ala Leu Phe Tyr Arg Leu Asp Val Val 
    130                 135                 140                 


Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr 
145                 150                 155                 160 


Ser Thr Cys Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
                165                 170                 175     


Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
            180                 185                 190         


Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln 
        195                 200                 205             


Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
    210                 215                 220                 


Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Ser Asn Phe Thr 
225                 230                 235                 240 


Asp Asn Ala Lys Asn Ile Ile Val Gln Leu Lys Glu Ser Val Glu Ile 
                245                 250                 255     


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly 
            260                 265                 270         


Pro Gly Arg Cys Phe Tyr Thr Thr Gly Asp Ile Ile Gly Asp Ile Arg 
        275                 280                 285             


Gln Ala His Cys Asn Ile Ser Arg Thr Lys Trp Asn Asn Thr Leu Asn 
    290                 295                 300                 


Gln Ile Ala Thr Lys Leu Lys Glu Gln Phe Gly Asn Asn Lys Thr Ile 
305                 310                 315                 320 


Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser 
                325                 330                 335     


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe 
            340                 345                 350         


Asn Ser Thr Trp Asn Phe Asn Gly Thr Trp Asn Leu Thr Gln Ser Asn 
        355                 360                 365             


Gly Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
    370                 375                 380                 


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro 
385                 390                 395                 400 


Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu 
                405                 410                 415     


Thr Arg Asp Gly Gly Asn Asn His Asn Asn Asp Thr Glu Thr Phe Arg 
            420                 425                 430         


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
        435                 440                 445             


Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Cys 
    450                 455                 460                 


Lys Arg Arg Val Val Gln Arg Arg Arg Arg Lys Arg Ala Val Gly Thr 
465                 470                 475                 480 


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
                485                 490                 495     


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser 
            500                 505                 510         


Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Pro Glu Ala Gln 
        515                 520                 525             


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
    530                 535                 540                 


Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
545                 550                 555                 560 


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Ala Val Pro Trp 
                565                 570                 575     


Asn Ala Ser Trp Ser Asn Lys Thr Leu Asp Met Ile Trp Asn Asn Met 
            580                 585                 590         


Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile 
        595                 600                 605             


Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
    610                 615                 620                 


Glu Leu Leu Glu Leu Asp Gly Ser 
625                 630         


<210>  18
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues corresponding to HIV1 env with N-terminal 
       leader sequence and C-terminal HIS tag

<400>  18

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Glu Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met 
                85                  90                  95      


His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu Arg Asn 
        115                 120                 125             


Val Thr Ser Ser Glu Gly Met Arg Gly Glu Ile Lys Asn Cys Ser Phe 
    130                 135                 140                 


Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Lys Lys Asp Tyr Ala Leu 
145                 150                 155                 160 


Phe Tyr Arg Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr 
                165                 170                 175     


Arg Leu Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln Ala Cys Pro Lys 
            180                 185                 190         


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe 
        195                 200                 205             


Ala Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys 
    210                 215                 220                 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val 
225                 230                 235                 240 


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val 
                245                 250                 255     


Ile Arg Ser Ser Asn Phe Thr Asp Asn Ala Lys Asn Ile Ile Val Gln 
            260                 265                 270         


Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
        275                 280                 285             


Arg Lys Ser Ile His Ile Gly Pro Gly Arg Cys Phe Tyr Thr Thr Gly 
    290                 295                 300                 


Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Thr 
305                 310                 315                 320 


Lys Trp Asn Asn Thr Leu Asn Gln Ile Ala Thr Lys Leu Lys Glu Gln 
                325                 330                 335     


Phe Gly Asn Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Phe Asn Gly Thr 
    370                 375                 380                 


Trp Asn Leu Thr Gln Ser Asn Gly Thr Glu Gly Asn Asp Thr Ile Thr 
385                 390                 395                 400 


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
                405                 410                 415     


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
            420                 425                 430         


Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Asn His Asn 
        435                 440                 445             


Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
    450                 455                 460                 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
465                 470                 475                 480 


Gly Val Ala Pro Thr Lys Cys Lys Arg Arg Val Val Gln Arg Arg Arg 
                485                 490                 495     


Arg Lys Arg Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
    530                 535                 540                 


Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
                565                 570                 575     


Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Cys Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Thr Leu 
        595                 600                 605             


Asp Met Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Gly Ser His 
                645                 650                 655     


His His His His His 
            660     


<210>  19
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H77cdelta123

<400>  19

Glu Thr His Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His 
1               5                   10                  15      


Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp 
            20                  25                  30          


Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Cys Pro 
        35                  40                  45              


Glu Arg Leu Ala Ser Cys Gly Ser Ser Gly Cys Trp His Tyr Pro Pro 
    50                  55                  60                  


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
65                  70                  75                  80  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
                85                  90                  95      


Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu 
            100                 105                 110         


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
        115                 120                 125             


Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Gly Ser 
    130                 135                 140                 


Ser Gly Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
145                 150                 155                 160 


Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met Val Asp 
                165                 170                 175     


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr Ile 
            180                 185                 190         


Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala 
        195                 200                 205             


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp 
    210                 215                 220                 


Arg Ser Glu His His His His His His 
225                 230             


<210>  20
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Con1delta123

<400>  20

Gly Thr Tyr Gly Ser Ser Gly Gln Leu Val Asn Thr Asn Gly Ser Trp 
1               5                   10                  15      


His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly 
            20                  25                  30          


Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe Asn Ser Ser Gly Cys 
        35                  40                  45              


Pro Glu Arg Met Ala Ser Cys Gly Ser Ser Gly Cys Trp His Tyr Ala 
    50                  55                  60                  


Pro Arg Pro Cys Gly Ile Val Pro Ala Ala Gln Val Cys Gly Pro Val 
65                  70                  75                  80  


Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Phe 
                85                  90                  95      


Gly Val Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Leu Leu 
            100                 105                 110         


Leu Asn Asn Thr Arg Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp 
        115                 120                 125             


Met Asn Ser Thr Gly Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Gly 
    130                 135                 140                 


Ser Ser Gly Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr 
145                 150                 155                 160 


Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val 
                165                 170                 175     


His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr 
            180                 185                 190         


Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu 
        195                 200                 205             


Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp Arg 
    210                 215                 220                 


Asp Arg Ser Glu 
225             


<210>  21
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S52delta123

<400>  21

Glu Thr His Gln Lys Leu Gln Leu Val Asn Thr Asn Gly Ser Trp His 
1               5                   10                  15      


Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser Ile Asn Thr Gly Phe 
            20                  25                  30          


Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn Ser Thr Gly Cys Pro 
        35                  40                  45              


Gln Arg Leu Ser Ser Cys Gly Ser Ser Gly Cys Trp His Tyr Ala Pro 
    50                  55                  60                  


Arg Pro Cys Ser Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr 
65                  70                  75                  80  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly 
                85                  90                  95      


Lys Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu 
            100                 105                 110         


Glu Ser Leu Arg Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met 
        115                 120                 125             


Asn Ser Thr Gly Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Gly Ser 
    130                 135                 140                 


Ser Gly Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
145                 150                 155                 160 


Ser Arg Cys Gly Ala Gly Pro Trp Leu Thr Pro Arg Cys Met Val Asp 
                165                 170                 175     


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Leu 
            180                 185                 190         


Phe Lys Val Arg Met Phe Val Gly Gly Phe Glu His Arg Phe Thr Ala 
        195                 200                 205             


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Ile Glu Asp Arg Asp 
    210                 215                 220                 


Arg Ser Glu 
225         


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human trypsinogen signal peptide

<400>  22

Met Asn Pro Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Leu Ala 
1               5                   10                  15  


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human tissue plasminogen activator signal peptide (tPA)

<400>  23

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser 
            20              


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6 HIS tag

<400>  24

His His His His His His 
1               5       


