                               SEQUENCE LISTING

<110> THORNE, STEPHEN H.
 
<120> HIGH MOBILITY GROUP BOX I MUTANT

<130> 52663-702.601

<140> PCT/US2017/052746
<141> 2017-09-21

<150> 62/397,523
<151> 2016-09-21

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (706)..(714)
<223> a, c, t, g, unknown or other

<400> 1
ctcgagatgg actggacatg gattctcttt ctagtggccg cagccacaag ggtccactcc       60

atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg      120

caaacttgcc gggaggagca caagaagaag cacccggatg ctgcagtcaa cttcgctgag      180

ttcgcaaaga agtgcgctga gaggtggaag accatggcag ctaaagaaaa ggggaaattt      240

gaagatatgg caaaggctga caaggctcgt tatgaaagag aaatgaaaac ctacatcccc      300

cccaaagggg agaccaaaaa gaagttcaag gaccccaatg cacccaagag gcctccttcg      360

gccttcttct tgttctgttc tgagtaccgc cccaaaatca aaggcgagca tcctggctta      420

tccattggtg atgttgcaaa gaaactagga gagatgtgga acaacactgc agcagatgac      480

aagcagccct atgagaagaa agctgccaag ctgaaggaga agtatgagaa ggatattgct      540

gcctacagag ctaaaggaaa acctgatgca gcgaaaaagg gggtggtcaa ggctgaaaag      600

gcgaagaaaa agaaggaaga ggaagatgat gaggaggatg aagaggatga ggaagaggag      660

gaagaagagg aagacgaaga tgaagaagaa gatgatgatg atgaannnnn nnnn            714


<210> 2
<211> 186
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
ctcgagatgg actggacatg gattctcttt ctagtggccg cagccacaag ggtccactcc       60

atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg      120

caaacttgcc gggaggagca caagaagaag cacccggatg ctgcagtcaa cttcgctgag      180

ttcgca                                                                 186


<210> 3
<211> 498
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (490)..(498)
<223> a, c, t, g, unknown or other

<400> 3
gcagctaaag aaaaggggaa atttgaagat atggcaaagg ctgacaaggc tcgttatgaa       60

agagaaatga aaacctacat cccccccaaa ggggagacca aaaagaagtt caaggacccc      120

aatgcaccca agaggcctcc ttcggccttc ttcttgttct gttctgagta ccgccccaaa      180

atcaaaggcg agcatcctgg cttatccatt ggtgatgttg caaagaaact aggagagatg      240

tggaacaaca ctgcagcaga tgacaagcag ccctatgaga agaaagctgc caagctgaag      300

gagaagtatg agaaggatat tgctgcctac agagctaaag gaaaacctga tgcagcgaaa      360

aagggggtgg tcaaggctga aaaggcgaag aaaaagaagg aagaggaaga tgatgaggag      420

gatgaagagg atgaggaaga ggaggaagaa gaggaagacg aagatgaaga agaagatgat      480

gatgatgaan nnnnnnnn                                                    498


<210> 4
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Leu Glu Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr 
1               5                   10                  15      


Arg Val His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys 
            20                  25                  30          


Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys 
        35                  40                  45              


Lys Lys His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys 
    50                  55                  60                  


Cys Ala Glu Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe 
65                  70                  75                  80  


Glu Asp Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys 
                85                  90                  95      


Thr Tyr Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro 
            100                 105                 110         


Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu 
        115                 120                 125             


Tyr Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp 
    130                 135                 140                 


Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp 
145                 150                 155                 160 


Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu 
                165                 170                 175     


Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys 
            180                 185                 190         


Lys Gly Val Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu 
        195                 200                 205             


Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Asp Glu Asp Glu Glu Glu Asp Asp Asp Asp Glu Glu Ala Ser 
225                 230                 235             


<210> 5
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Leu Glu Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr 
1               5                   10                  15      


Arg Val His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys 
            20                  25                  30          


Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys 
        35                  40                  45              


Lys Lys His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala 
    50                  55                  60          


<210> 6
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys 
1               5                   10                  15      


Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro Lys Gly Glu 
            20                  25                  30          


Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser 
        35                  40                  45              


Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile Lys Gly Glu 
    50                  55                  60                  


His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met 
65                  70                  75                  80  


Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala 
                85                  90                  95      


Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala 
            100                 105                 110         


Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys Ala Glu Lys 
        115                 120                 125             


Ala Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp Glu Glu Asp 
    130                 135                 140                 


Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Asp Asp 
145                 150                 155                 160 


Asp Asp Glu Ala Ser 
                165 


<210> 7
<211> 60
<212> DNA
<213> Homo sapiens

<400> 7
tttaaagatc cgaacgcgcc gaaacgcccg ccgagcgcgt tttttctgtt ttgcagcgaa       60


<210> 8
<211> 20
<212> PRT
<213> Homo sapiens

<400> 8
Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu 
1               5                   10                  15      


Phe Cys Ser Glu 
            20  


<210> 9
<211> 102
<212> DNA
<213> Homo sapiens

<400> 9
aaactgaaag aaaaatatga aaaagatatt gcggcgtatc gcgcgaaagg caaaccggat       60

gcggcgaaaa aaggcgtggt gaaagcggaa aaaagcaaaa aa                         102


<210> 10
<211> 34
<212> PRT
<213> Homo sapiens

<400> 10
Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys 
1               5                   10                  15      


Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys Ala Glu Lys Ser 
            20                  25                  30          


Lys Lys 
        


<210> 11
<211> 1341
<212> DNA
<213> Homo sapiens

<400> 11
ctgaactttc gcgcgccgcc ggtgattccg aacgtgccgt ttctgtgggc gtggaacgcg       60

ccgagcgaat tttgcctggg caaatttgat gaaccgctgg atatgagcct gtttagcttt      120

attggcagcc cgcgcattaa cgcgaccggc cagggcgtga ccatttttta tgtggatcgc      180

ctgggctatt atccgtatat tgatagcatt accggcgtga ccgtgaacgg cggcattccg      240

cagaaaatta gcctgcagga tcatctggat aaagcgaaaa aagatattac cttttatatg      300

ccggtggata acctgggcat ggcggtgatt gattgggaag aatggcgccc gacctgggcg      360

cgcaactgga aaccgaaaga tgtgtataaa aaccgcagca ttgaactggt gcagcagcag      420

aacgtgcagc tgagcctgac cgaagcgacc gaaaaagcga aacaggaatt tgaaaaagcg      480

ggcaaagatt ttctggtgga aaccattaaa ctgggcaaac tgctgcgccc gaaccatctg      540

tggggctatt atctgtttcc ggattgctat aaccatcatt ataaaaaacc gggctataac      600

ggcagctgct ttaacgtgga aattaaacgc aacgatgatc tgagctggct gtggaacgaa      660

agcaccgcgc tgtatccgag catttatctg aacacccagc agagcccggt ggcggcgacc      720

ctgtatgtgc gcaaccgcgt gcgcgaagcg attcgcgtga gcaaaattcc ggatgcgaaa      780

agcccgctgc cggtgtttgc gtatacccgc attgtgttta ccgatcaggt gctgaaattt      840

ctgagccagg atgaactggt gtataccttt ggcgaaaccg tggcgctggg cgcgagcggc      900

attgtgattt ggggcaccct gagcattatg cgcagcatga aaagctgcct gctgctggat      960

aactatatgg aaaccattct gaacccgtat attattaacg tgaccctggc ggcgaaaatg     1020

tgcagccagg tgctgtgcca ggaacagggc gtgtgcattc gcaaaaactg gaacagcagc     1080

gattatctgc atctgaaccc ggataacttt gcgattcagc tggaaaaagg cggcaaagaa     1140

accgtgcgcg gcaaaccgac cctggaagat ctggaacagt ttagcgaaaa attttattgc     1200

agctgctata gcaccctgag ctgcaaagaa aaagcggatg tgaaagatac cgatgcggtg     1260

gatgtgtgca ttgcggatgg cgtgtgcatt gatgcgtttc tgaaaccgcc gatggaaacc     1320

gaagaaccgc agatttttta t                                               1341


<210> 12
<211> 447
<212> PRT
<213> Homo sapiens

<400> 12
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp 
1               5                   10                  15      


Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro 
            20                  25                  30          


Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala 
        35                  40                  45              


Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr 
    50                  55                  60                  


Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro 
65                  70                  75                  80  


Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile 
                85                  90                  95      


Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp 
            100                 105                 110         


Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val 
        115                 120                 125             


Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu 
    130                 135                 140                 


Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala 
145                 150                 155                 160 


Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg 
                165                 170                 175     


Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His 
            180                 185                 190         


His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile 
        195                 200                 205             


Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu 
    210                 215                 220                 


Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr 
225                 230                 235                 240 


Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile 
                245                 250                 255     


Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val 
            260                 265                 270         


Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr 
        275                 280                 285             


Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp 
    290                 295                 300                 


Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp 
305                 310                 315                 320 


Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu 
                325                 330                 335     


Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys 
            340                 345                 350         


Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp 
        355                 360                 365             


Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Glu Thr Val Arg Gly 
    370                 375                 380                 


Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys 
385                 390                 395                 400 


Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp 
                405                 410                 415     


Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala 
            420                 425                 430         


Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr 
        435                 440                 445         


<210> 13
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
ctcgagatgg actggacatg gattctcttt ctagtggccg cagccacaag ggtccactcc       60

atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg      120

caaacttgcc gggaggagca caagaagaag cacccggatg ctgcagtcaa cttcgctgag      180

ttcgcaaaga agtgcgctga gaggtggaag accatggcag ctaaagaaaa ggggaaattt      240

gaagatatgg caaaggctga caaggctcgt tatgaaagag aaatgaaaac ctacatcccc      300

cccaaagggg agaccaaaaa gaagttcaag gaccccaatg cacccaagag gcctccttcg      360

gccttcttct tgttctgttc tgagtaccgc cccaaaatca aaggcgagca tcctggctta      420

tccattggtg atgttgcaaa gaaactagga gagatgtgga acaacactgc agcagatgac      480

aagcagccct atgagaagaa agctgccaag ctgaaggaga agtatgagaa ggatattgct      540

gcctacagag ctaaaggaaa acctgatgca gcgaaaaagg gggtggtcaa ggctgaaaag      600

gcgaagaaaa agaaggaaga ggaagatgat gaggaggatg aagaggatga ggaagaggag      660

gaagaagagg aagacgaaga tgaagaagaa gatgatgatg atgaa                      705


<210> 14
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (706)..(708)
<223> a, c, t, g, unknown or other

<400> 14
ctcgagatgg actggacatg gattctcttt ctagtggccg cagccacaag ggtccactcc       60

atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg      120

caaacttgcc gggaggagca caagaagaag cacccggatg ctgcagtcaa cttcgctgag      180

ttcgcaaaga agtgcgctga gaggtggaag accatggcag ctaaagaaaa ggggaaattt      240

gaagatatgg caaaggctga caaggctcgt tatgaaagag aaatgaaaac ctacatcccc      300

cccaaagggg agaccaaaaa gaagttcaag gaccccaatg cacccaagag gcctccttcg      360

gccttcttct tgttctgttc tgagtaccgc cccaaaatca aaggcgagca tcctggctta      420

tccattggtg atgttgcaaa gaaactagga gagatgtgga acaacactgc agcagatgac      480

aagcagccct atgagaagaa agctgccaag ctgaaggaga agtatgagaa ggatattgct      540

gcctacagag ctaaaggaaa acctgatgca gcgaaaaagg gggtggtcaa ggctgaaaag      600

gcgaagaaaa agaaggaaga ggaagatgat gaggaggatg aagaggatga ggaagaggag      660

gaagaagagg aagacgaaga tgaagaagaa gatgatgatg atgaannngc tagc            714


<210> 15
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Leu Glu Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr 
1               5                   10                  15      


Arg Val His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys 
            20                  25                  30          


Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys 
        35                  40                  45              


Lys Lys His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys 
    50                  55                  60                  


Cys Ala Glu Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe 
65                  70                  75                  80  


Glu Asp Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys 
                85                  90                  95      


Thr Tyr Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro 
            100                 105                 110         


Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu 
        115                 120                 125             


Tyr Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp 
    130                 135                 140                 


Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp 
145                 150                 155                 160 


Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu 
                165                 170                 175     


Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys 
            180                 185                 190         


Lys Gly Val Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu 
        195                 200                 205             


Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Asp Glu Asp Glu Glu Glu Asp Asp Asp Asp Glu 
225                 230                 235 


<210> 16
<211> 215
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210> 17
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (236)..(236)
<223> Any amino acid

<400> 17
Leu Glu Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr 
1               5                   10                  15      


Arg Val His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys 
            20                  25                  30          


Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys 
        35                  40                  45              


Lys Lys His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys 
    50                  55                  60                  


Cys Ala Glu Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe 
65                  70                  75                  80  


Glu Asp Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys 
                85                  90                  95      


Thr Tyr Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro 
            100                 105                 110         


Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu 
        115                 120                 125             


Tyr Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp 
    130                 135                 140                 


Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp 
145                 150                 155                 160 


Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu 
                165                 170                 175     


Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys 
            180                 185                 190         


Lys Gly Val Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu 
        195                 200                 205             


Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Asp Glu Asp Glu Glu Glu Asp Asp Asp Asp Glu Xaa Ala Ser 
225                 230                 235             


<210> 18
<211> 428
<212> PRT
<213> Homo sapiens

<400> 18
Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys 
1               5                   10                  15      


Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr 
            20                  25                  30          


Gly Tyr Phe Pro Glu Pro Val Met Val Thr Trp Asp Thr Gly Ser Leu 
        35                  40                  45              


Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly 
    50                  55                  60                  


His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys 
65                  70                  75                  80  


Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp 
                85                  90                  95      


Val Asp Asn Lys Thr Phe Ser Val Cys Ser Arg Asp Phe Thr Pro Pro 
            100                 105                 110         


Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro 
        115                 120                 125             


Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr 
    130                 135                 140                 


Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu 
145                 150                 155                 160 


Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser 
                165                 170                 175     


Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr 
            180                 185                 190         


Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys 
        195                 200                 205             


Cys Ala Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro 
    210                 215                 220                 


Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu 
225                 230                 235                 240 


Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser 
                245                 250                 255     


Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys 
            260                 265                 270         


Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr 
        275                 280                 285             


Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro 
    290                 295                 300                 


His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro 
305                 310                 315                 320 


Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly 
                325                 330                 335     


Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro 
            340                 345                 350         


Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp 
        355                 360                 365             


Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe 
    370                 375                 380                 


Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys 
385                 390                 395                 400 


Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln 
                405                 410                 415     


Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            420                 425             


<210> 19
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
ctcgagatgg actggacatg gattctcttt ctagtggccg cagccacaag ggtccactcc       60

atgggcaaag gagatcctaa aaagccgaga ggcaaaatgt cctcatatgc attctttgtg      120

caaacttgcc gggaggagca caagaagaag cacccggatg ctgcagtcaa cttcgctgag      180

ttcgcaaaga agtgcgctga gaggtggaag accatggcag ctaaagaaaa ggggaaattt      240

gaagatatgg caaaggctga caaggctcgt tatgaaagag aaatgaaaac ctacatcccc      300

cccaaagggg agaccaaaaa gaagttcaag gaccccaatg cacccaagag gcctccttcg      360

gccttcttct tgttctgttc tgagtaccgc cccaaaatca aaggcgagca tcctggctta      420

tccattggtg atgttgcaaa gaaactagga gagatgtgga acaacactgc agcagatgac      480

aagcagccct atgagaagaa agctgccaag ctgaaggaga agtatgagaa ggatattgct      540

gcctacagag ctaaaggaaa acctgatgca gcgaaaaagg gggtggtcaa ggctgaaaag      600

gcgaagaaaa agaaggaaga ggaagatgat gaggaggatg aagaggatga ggaagaggag      660

gaagaagagg aagacgaaga tgaagaagaa gatgatgatg atgaagaagc tagc            714


<210> 20
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Lys Lys Lys His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys 
1               5                   10                  15      


Lys Cys Ala Glu Arg Trp Lys Thr Met Ala Ala 
            20                  25          


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Glu Lys Ala Lys Lys Lys Lys 
1               5           


<210> 22
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210> 23
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (216)..(216)
<223> Any amino acid

<400> 23
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu Xaa Ala Ser 
    210                 215             


<210> 24
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser 
            20                  25                  30          


Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys 
        35                  40                  45              


His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala 
    50                  55                  60                  


Glu Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp 
65                  70                  75                  80  


Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr 
                85                  90                  95      


Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro Asn Ala 
            100                 105                 110         


Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg 
        115                 120                 125             


Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala 
    130                 135                 140                 


Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln 
145                 150                 155                 160 


Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp 
                165                 170                 175     


Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly 
            180                 185                 190         


Val Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Asp Asp 
        195                 200                 205             


Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Glu Asp Asp Asp Asp Glu 
225                 230             


<210> 25
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (234)..(234)
<223> Any amino acid

<400> 25
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser 
            20                  25                  30          


Ser Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys 
        35                  40                  45              


His Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala 
    50                  55                  60                  


Glu Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp 
65                  70                  75                  80  


Met Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr 
                85                  90                  95      


Ile Pro Pro Lys Gly Glu Thr Lys Lys Lys Glu Lys Asp Pro Asn Ala 
            100                 105                 110         


Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg 
        115                 120                 125             


Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala 
    130                 135                 140                 


Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln 
145                 150                 155                 160 


Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp 
                165                 170                 175     


Ile Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly 
            180                 185                 190         


Val Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Asp Asp 
        195                 200                 205             


Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Glu Asp Asp Asp Asp Glu Xaa Ala Ser 
225                 230                 235     



