                         SEQUENCE LISTING

<110>  NextCure, Inc.
       Liu, Linda
       Flies, Dallas
       Langermann, Solomon
 
<120>  ANTIBODIES FOR SIGLEC-15 AND

<130>  064467.003PCT

<140>  PCT/US17/52714
<141>  2017-09-21

<150>  62/397,794
<151>  2016-09-21

<150>  62/451,271
<151>  2017-01-27

<150>  62/500,578
<151>  2017-05-03

<160>  217   

<170>  PatentIn version 3.5

<210>  1
<211>  328
<212>  PRT
<213>  homo sapiens

<400>  1

Met Glu Lys Ser Ile Trp Leu Leu Ala Cys Leu Ala Trp Val Leu Pro 
1               5                   10                  15      


Thr Gly Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr Val Ala Leu Leu Leu Gly Ala Leu Gly 
            260                 265                 270         


Phe Lys Ala Leu Leu Leu Leu Gly Val Leu Ala Ala Arg Ala Ala Arg 
        275                 280                 285             


Arg Arg Pro Glu His Leu Asp Thr Pro Asp Thr Pro Pro Arg Ser Gln 
    290                 295                 300                 


Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Asn Pro Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Thr Met Cys Ser Pro 
                325             


<210>  2
<211>  342
<212>  PRT
<213>  mus musculus

<400>  2

Met Glu Gly Ser Leu Gln Leu Leu Ala Cys Leu Ala Cys Val Leu Gln 
1               5                   10                  15      


Met Gly Ser Leu Val Lys Thr Arg Arg Asp Ala Ser Gly Asp Leu Leu 
            20                  25                  30          


Asn Thr Glu Ala His Ser Ala Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Ala Glu Val Asn Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ser Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Thr 
                85                  90                  95      


Ala Ala Pro Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Ser Gly Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Thr Gly Asp Ala His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu Arg Val Thr Ala Ala Ala Pro Arg Ile Val Asn Ile Ser Val 
                165                 170                 175     


Leu Pro Gly Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly 
            180                 185                 190         


Glu Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Pro Gly Asn Ser 
        195                 200                 205             


Ser Ala Ala Leu Gln Gly Gln Gly His Gly Tyr Gln Val Thr Ala Glu 
    210                 215                 220                 


Leu Pro Ala Leu Thr Arg Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn 
225                 230                 235                 240 


Ser Leu Gly Arg Ala Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly 
                245                 250                 255     


Ala Pro Gly Thr Ser Thr Leu Ala Leu Leu Leu Gly Ala Leu Gly Leu 
            260                 265                 270         


Lys Ala Leu Leu Leu Leu Gly Ile Leu Gly Ala Arg Ala Thr Arg Arg 
        275                 280                 285             


Arg Leu Asp His Leu Val Pro Gln Asp Thr Pro Pro Arg Ser Gln Ala 
    290                 295                 300                 


Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Ser Pro Pro Gly His 
305                 310                 315                 320 


Gln Leu Pro Arg Val Cys Cys Glu Glu Leu Leu Ser His His His Leu 
                325                 330                 335     


Val Ile His His Glu Lys 
            340         


<210>  3
<211>  112
<212>  PRT
<213>  mus musculus

<400>  3

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  mus musculus

<400>  4

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  107
<212>  PRT
<213>  mus musculus

<400>  5

Asp Ile Gln Met Thr Gln Ala Ser Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  6
<211>  106
<212>  PRT
<213>  mus musculus

<400>  6

Gln Ile Ile Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Thr Ser Phe Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ala Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  7
<211>  108
<212>  PRT
<213>  mus musculus

<400>  7

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  113
<212>  PRT
<213>  mus musculus

<400>  8

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  9
<211>  112
<212>  PRT
<213>  mus musculus

<400>  9

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  109
<212>  PRT
<213>  mus musculus

<400>  10

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Thr Gly 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  11
<211>  112
<212>  PRT
<213>  mus musculus

<400>  11

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  109
<212>  PRT
<213>  mus musculus

<400>  12

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  13
<211>  119
<212>  PRT
<213>  mus musculus

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Ile Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Tyr His Gly Asn Gly Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  14
<211>  116
<212>  PRT
<213>  mus musculus

<400>  14

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Gly Pro Gly Ser Val Ser Ile Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  15
<211>  123
<212>  PRT
<213>  mus musculus

<400>  15

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Gly Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  119
<212>  PRT
<213>  mus musculus

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Ile Leu Tyr Tyr Ala Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Tyr His Gly Asn Gly Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  17
<211>  120
<212>  PRT
<213>  mus musculus

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Glu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Asp Ile Glu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Asp Tyr Asp Tyr Asp Gly Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  18
<211>  122
<212>  PRT
<213>  mus musculus

<400>  18

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Cys Gly Ser Asp Thr Met His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  116
<212>  PRT
<213>  mus musculus

<400>  19

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Gly Pro Gly Ser Val Ser Ile Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  mus musculus

<400>  20

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Gly Pro Glu Ser Val Ser Ile Tyr Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  21
<211>  118
<212>  PRT
<213>  mus musculus

<400>  21

Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Gly Leu Ser Cys Glu Gly Ser Gly Phe Thr Phe Ser Gly Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asp Gly Ser Ala Ile Asn Tyr Ala Pro Ser Ile 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Phe Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Val Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Tyr Asp Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  22
<211>  116
<212>  PRT
<213>  mus musculus

<400>  22

His Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Leu Ile Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ser Ser Pro His Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  23
<211>  118
<212>  PRT
<213>  mus musculus

<400>  23

Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Gly Leu Ser Cys Glu Gly Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asp Gly Ser Ala Val Asn Tyr Ala Pro Ser Ile 
    50                  55                  60                  


Lys Asp Gln Phe Thr Ile Phe Arg Asp Asn Asp Lys Arg Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Ile Asn Val Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Tyr Asp Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  24
<211>  16
<212>  PRT
<213>  mus musclus

<400>  24

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  mus musclus

<400>  25

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  26
<211>  11
<212>  PRT
<213>  mus musclus

<400>  26

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  27
<211>  10
<212>  PRT
<213>  mus musclus

<400>  27

Ser Ala Ser Ser Ser Thr Ser Phe Met His 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  mus musculus

<400>  28

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  29
<211>  14
<212>  PRT
<213>  mus musculus

<400>  29

Arg Ser Ser Ser Gly Ala Val Thr Thr Gly Asn Phe Ala Asn 
1               5                   10                  


<210>  30
<211>  16
<212>  PRT
<213>  mus musclus

<400>  30

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  31
<211>  14
<212>  PRT
<213>  mus musculus

<400>  31

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  32
<211>  7
<212>  PRT
<213>  mus musculus

<400>  32

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  mus musculus

<400>  33

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  mus musculus

<400>  34

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  35
<211>  6
<212>  PRT
<213>  mus musculus

<400>  35

Asp Thr Ser Lys Leu Ala 
1               5       


<210>  36
<211>  7
<212>  PRT
<213>  37-8H8 LC CDR2

<400>  36

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  mus musculus

<400>  37

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  mus musculus

<400>  38

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  mus musculus

<400>  39

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  mus musculus

<400>  40

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  mus musculus

<400>  41

Gln Gln Tyr Trp Ser Ser Pro Leu Thr 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  mus musculus

<400>  42

His Gln Arg Ser Ala Tyr Pro Trp Thr 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  mus musculus

<400>  43

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  mus musculus

<400>  44

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  mus musculus

<400>  45

Trp Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  mus musculus

<400>  46

Gly Phe Thr Phe Ser Asp Tyr Gly Met His 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  mus musculus

<400>  47

Gly Tyr Ile Phe Thr Asp Tyr Tyr Val Asn 
1               5                   10  


<210>  48
<211>  5
<212>  PRT
<213>  mus musculus

<400>  48

Asn Tyr Gly Val His 
1               5   


<210>  49
<211>  10
<212>  PRT
<213>  mus musculus

<400>  49

Gly Phe Ser Phe Ser Asp Tyr Gly Met His 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  mus musculus

<400>  50

Gly Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  mus musculus

<400>  51

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Thr 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  mus musculus

<400>  52

Gly Tyr Thr Phe Thr Asp Tyr Tyr Val Asn 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  mus musculus

<400>  53

Gly Phe Thr Phe Ser Gly Phe Trp Met Ser 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  mus musculus

<400>  54

Gly Tyr Thr Phe Thr Ser Tyr Gly Leu Ile 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  mus musclus

<400>  55

Gly Phe Thr Phe Ser Asp Phe Trp Met Ser 
1               5                   10  


<210>  56
<211>  17
<212>  PRT
<213>  mus musculus

<400>  56

Tyr Ile Ser Ser Gly Ser Ser Ile Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  mus musculus

<400>  57

Lys Ile Gly Pro Gly Ser Val Ser Ile Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  16
<212>  PRT
<213>  mus musculus

<400>  58

Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  59
<211>  32
<212>  PRT
<213>  mus musculus

<400>  59

Tyr Ile Ser Ser Gly Ser Ser Ile Leu Tyr Tyr Ala Asp Ile Val Lys 
1               5                   10                  15      


Tyr Ile Ser Ser Gly Ser Ser Ile Leu Tyr Tyr Ala Asp Ile Val Lys 
            20                  25                  30          


<210>  60
<211>  17
<212>  PRT
<213>  mus musculus

<400>  60

Arg Ile Asp Pro Glu Asp Gly Asp Ile Glu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  17
<212>  PRT
<213>  mus musculus

<400>  61

Asp Ile Tyr Cys Gly Ser Asp Thr Met His Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  62
<211>  17
<212>  PRT
<213>  mus musculus

<400>  62

Lys Ile Gly Pro Gly Ser Val Ser Ile Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  63
<211>  17
<212>  PRT
<213>  mus musculus

<400>  63

Lys Ile Gly Pro Glu Ser Val Ser Ile Tyr Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  64
<211>  17
<212>  PRT
<213>  mus musculus

<400>  64

Asp Ile Asn Ser Asp Gly Ser Ala Ile Asn Tyr Ala Pro Ser Ile Lys 
1               5                   10                  15      


Asp 
    


<210>  65
<211>  17
<212>  PRT
<213>  mus musculus

<400>  65

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  17
<212>  PRT
<213>  mus musculus

<400>  66

Asp Ile Asn Ser Asp Gly Ser Ala Val Asn Tyr Ala Pro Ser Ile Lys 
1               5                   10                  15      


Asp 
    


<210>  67
<211>  10
<212>  PRT
<213>  mus musculus

<400>  67

Asp His Tyr His Gly Asn Gly Ser Asp Tyr 
1               5                   10  


<210>  68
<211>  7
<212>  PRT
<213>  mus musculus

<400>  68

Tyr Tyr Tyr Gly Phe Ala Tyr 
1               5           


<210>  69
<211>  15
<212>  PRT
<213>  mus musculus

<400>  69

His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
1               5                   10                  15  


<210>  70
<211>  11
<212>  PRT
<213>  mus musculus

<400>  70

Asp Tyr Asp Tyr Asp Gly Gly Trp Phe Ala Tyr 
1               5                   10      


<210>  71
<211>  13
<212>  PRT
<213>  mus musculus

<400>  71

Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  72
<211>  9
<212>  PRT
<213>  mus musculus

<400>  72

Tyr Asp Asp Tyr Gly Tyr Phe Asp Val 
1               5                   


<210>  73
<211>  7
<212>  PRT
<213>  mus musculus

<400>  73

Ser Ser Pro His Gly Asp Tyr 
1               5           


<210>  74
<211>  336
<212>  DNA
<213>  mus msuculus

<400>  74
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaag                                336


<210>  75
<211>  336
<212>  DNA
<213>  mus musculus

<400>  75
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttatattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cggtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtttt tattactgta tgcaacatct agaatatccg      300

tacacgttcg gaggggggac caggctggaa ataaaa                                336


<210>  76
<211>  321
<212>  DNA
<213>  mus musculus

<400>  76
gacatccaga tgacacaggc ttcatcctcc ttgtctgtat ctctaggagg cagagtcacc       60

attacttgca aggcaagtga ccacattaat aattggttgg cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagtt ctcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  77
<211>  335
<212>  DNA
<213>  mus musculus

<400>  77
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaa                                 335


<210>  78
<211>  318
<212>  DNA
<213>  mus musculus

<400>  78
caaattattc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtacaagt ttcatgcact ggtaccagca gaagccaggc      120

acctccccca aaagatggat ttttgacaca tccaaactgg cttctggagt ccctggtcgc      180

ttcattggta gtgggtctgg gacctcttat tctctcacaa tcagcaccat ggaggctgaa      240

gatgctgcca cttattactg ccatcagcgg agtgcttacc catggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  79
<211>  321
<212>  DNA
<213>  mus musculus

<400>  79
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  80
<211>  336
<212>  DNA
<213>  mus musculus

<400>  80
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cggtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattattgta tgcaacatct agaatatccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  81
<211>  336
<212>  DNA
<213>  mus musculus

<400>  81
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cggtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  82
<211>  327
<212>  DNA
<213>  mus musculus

<400>  82
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagttctgg ggctgttaca actggtaact ttgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  83
<211>  336
<212>  DNA
<213>  mus musculus

<400>  83
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca gtcagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  84
<211>  327
<212>  DNA
<213>  mus musculus

<400>  84
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  85
<211>  357
<212>  DNA
<213>  mus musculus

<400>  85
gaggtgcagc tggtggagtc tgggggaggc ttcgtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gactatggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggttgcatac attagtagtg gcagtagtat catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgttc      240

ctgcaaatga ccagtctgag gtctgaggac acggccatgt attactgtgc aagggaccac      300

taccatggta acgggtccga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  86
<211>  348
<212>  DNA
<213>  mus musculus

<400>  86
caggtccagc tgaagcagtc tggagctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta catcttcact gactattatg taaactgggt gaagcagagg      120

cctggacagg gccttgagtg gattggaaag attggtcctg gaagtgttag tatttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcagtct atttctgtgc aagttattac      300

tacgggtttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  87
<211>  369
<212>  DNA
<213>  mus musculus

<400>  87
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcaccg tctcagggtt ctcattaagc aattatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctggtactg atatggagtg atggaagcac aacctataat      180

tcagctctca aatccagact gagcatcagc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctccaaac tggtgacaca gccatgtact actgtgccag acatccctat      300

gatgattatt ccggctatta ctatactatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  88
<211>  357
<212>  DNA
<213>  mus musculus

<400>  88
gaggtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggttt ctctttcagt gactatggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggttgcatac attagtagtg gcagtagtat cctctactat      180

gcagacatag tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgttc      240

ctgcaaatga ccagtctgag gtctgaggac acggccatgt attactgtgc aagggaccac      300

taccatggta acgggtccga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  89
<211>  360
<212>  DNA
<213>  mus musculus

<400>  89
gaggttcagc tgcagcagtc tggggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactactata tgcactgggt gaaagagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg aggatggtga tattgaatat      180

gacccgaagt tccagggcaa ggccactatg actgcagata catcctccaa cacagcctac      240

ctgcagttca gcagcctgac atctgaggac actgccgtct attattgtgt cacggactat      300

gattacgacg gaggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  90
<211>  366
<212>  DNA
<213>  mus musculus

<400>  90
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcacc agctactgga taacctgggt gatacagagg      120

ccgggacaag gccttgagtg gattggagat atttattgtg gtagtgatac tatgcactac      180

aatgagaagt tcaagaacaa ggccacactg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagatggtgg      300

gactacggta gtagctacga ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  91
<211>  348
<212>  DNA
<213>  mus musculus

<400>  91
caggtccagc tgaagcagtc tggacctgaa ctggtgaggc ctggggcttc agtgaagata       60

tcctgcgagg cttctggcta caccttcact gactattatg taaactgggt gaagcagagg      120

cctggacggg gccttgagtg gattggaaag attggtcctg gaagtgttag tatttactac      180

aatgagaagt tcaaggacaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctgac atctgaggac tctgcagtct atttctgtgc aagttattac      300

tacggttttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  92
<211>  348
<212>  DNA
<213>  mus musculus

<400>  92
caggtccagc tgaagcagtc tggagctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact gactattatg taaactgggt gaagcagagg      120

cctggacagg gccttgagtg gattggaaag attggtcctg aaagtgttag tatttattac      180

agtgagaagt tcaaggccaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcagtct atttctgtgc aagttattac      300

tacgggtttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  93
<211>  354
<212>  DNA
<213>  mus musculus

<400>  93
gaagtgcagc tgttggagac tggaggaggc ttggtgcaac cgggggggtc acggggactc       60

tcttgtgaag gctcagggtt cacttttagt ggcttctgga tgagctgggt tcgacagaca      120

cctgggaaga ccctggagtg gattggagac attaattctg atggcagtgc aataaactac      180

gcaccatcca taaaggatcg attcactatc ttcagagaca atgacaagaa caccctgtac      240

ctgcagatga acaatgtgcg atcggaggac acagccacgt atttctgtgt gagatatgat      300

gattacgggt acttcgatgt ctggggcaca gggaccacgg tcaccgtctc ctca            354


<210>  94
<211>  348
<212>  DNA
<213>  mus musculus

<400>  94
cacgttcagc tgcagcagtc tggagctgag ttggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca agctatggtt taatctgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtaa tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca tatcctccag cacagcgtac      240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagttcctct      300

cctcacgggg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  95
<211>  354
<212>  DNA
<213>  mus musculus

<400>  95
gaagtgcagc tgttggagac tggaggaggc ttagtgcaac ctggggggtc acggggactc       60

tcttgtgaag gctcagggtt cacttttagt gacttctgga tgagctgggt tcgacagaca      120

cctgggaaga ccctggagtg gattggagac attaattctg atggcagtgc agttaactac      180

gcaccatcca taaaggatca attcactatc ttcagagaca atgacaagag gaccctgcac      240

ctgcagatga tcaatgttcg atcggaggac acagccacgt atttctgtgt gagatatgat      300

gattacgggt acttcgatgt ctggggcaca gggaccacgg tcaccgtctc ctca            354


<210>  96
<211>  112
<212>  PRT
<213>  mus musculus

<400>  96

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  97
<211>  112
<212>  PRT
<213>  mus musculus

<400>  97

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Ile Pro Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  98
<211>  112
<212>  PRT
<213>  mus musculus

<400>  98

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  99
<211>  112
<212>  PRT
<213>  mus musculus

<400>  99

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  100
<211>  112
<212>  PRT
<213>  mus musculus

<400>  100

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Lys Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Met Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  101
<211>  113
<212>  PRT
<213>  mus musculus

<400>  101

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Asn Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  102
<211>  112
<212>  PRT
<213>  mus musculus

<400>  102

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  103
<211>  107
<212>  PRT
<213>  mus msuculus

<400>  103

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Glu Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  104
<211>  104
<212>  PRT
<213>  mus musculus

<400>  104

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Ile Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Trp Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Gln Leu Glu Ile Lys 
            100                 


<210>  105
<211>  113
<212>  PRT
<213>  mus musculus

<400>  105

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Gln Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Met 
            100                 105                 110         


Lys 
    


<210>  106
<211>  112
<212>  PRT
<213>  mus musculus

<400>  106

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  107
<211>  112
<212>  PRT
<213>  mus musculus

<400>  107

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Leu Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ile Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105                 110         


<210>  108
<211>  115
<212>  PRT
<213>  mus musculus

<400>  108

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Thr 
        115 


<210>  109
<211>  115
<212>  PRT
<213>  mus musculus

<400>  109

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  110
<211>  115
<212>  PRT
<213>  mus musculus

<400>  110

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  111
<211>  115
<212>  PRT
<213>  mus musculus

<400>  111

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Asp Pro Glu Asn Gly Asp Ile Glu Tyr Ala Ser Arg Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Val Gly Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  112
<211>  115
<212>  PRT
<213>  mus musculus

<400>  112

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Val Gly Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  113
<211>  114
<212>  PRT
<213>  mus musculus

<400>  113

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Asp Glu Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Val Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Trp Phe Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  114
<211>  115
<212>  PRT
<213>  mus musculus

<400>  114

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asp 
            20                  25                  30          


Gly Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Gly Thr Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  115
<211>  115
<212>  PRT
<213>  mus musculus

<400>  115

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Trp Glu Asp Cys Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  116
<211>  121
<212>  PRT
<213>  mus musculus

<400>  116

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Phe Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg His Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Ile Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Ile Tyr Asp Gly Ser Ser Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  117
<211>  114
<212>  PRT
<213>  mus musculus

<400>  117

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Cys Leu Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  118
<211>  115
<212>  PRT
<213>  mus musculus

<400>  118

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asp 
            20                  25                  30          


Gly Ile Thr Trp Leu Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Gly Thr Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  119
<211>  115
<212>  PRT
<213>  mus musculus

<400>  119

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Ala Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  120
<211>  336
<212>  DNA
<213>  mus musculus

<400>  120
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaggatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  121
<211>  336
<212>  DNA
<213>  mus musculus

<400>  121
gatgttgtga tgacccagac tccactcact ttgtcgattc ccattggaca accagcctcc       60

atctcttgta agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctcatct atctggtgtc tgaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgaaga tttgggagtt tattattgtt ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  122
<211>  336
<212>  DNA
<213>  mus musculus

<400>  122
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgtt ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  123
<211>  336
<212>  DNA
<213>  mus musculus

<400>  123
gacgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gaaacaccta tttagaatgg      120

tacctacaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  124
<211>  336
<212>  DNA
<213>  mus musculus

<400>  124
gatgttttga tgacccaaag tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacatagta catagtaatg gtaacaccta tttagaatgg      120

tacctgaaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatg tattactgct ttcaaggttc acatgttccg      300

ctcacgttcg gagctgggac caagctggag ctgaaa                                336


<210>  125
<211>  339
<212>  DNA
<213>  mus musculus

<400>  125
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctgca agtccaatca gagtctgtta aacagtggag atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaactattga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca atttattact gtcagaatga ttatagttat      300

ccactcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  126
<211>  336
<212>  DNA
<213>  mus musculus

<400>  126
gatgttgtga tgacccagac tccactcact ttgtcggtta ctattggaca atcagcctcc       60

atctcttgca agtcaagtca gagcctccta gatagtgatg gaaacacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atttggtgtc tgaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  127
<211>  321
<212>  DNA
<213>  mus musculus

<400>  127
gaaatccaga tgacccagtc tccatcctct atgtctgcat ctctgggaga cagaataacc       60

atcacttgcc aggcaactca agacattgtt aagaatttaa actggtatca gcagaaacca      120

gggaaacccc cttcattcct gatctattat gcaactgaac tggcagaagg ggtcccatca      180

aggttcagtg gcagtgggtc tgggtcagac tattctctga caatcagcaa cctggagtct      240

gaagattttg cagactatta ctgtctacag ttttatgaat ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  128
<211>  312
<212>  DNA
<213>  mus musculus

<400>  128
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga ggagatcacc       60

ctaatttgca gtgccagctc gagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acttctccca aactcttgat ttatcgcaca tccaacctgg cttctggagt cccttctcgc      180

ttcagtggca gtgggtctgg gaccttttat tctcttacaa tcagcagtgt ggaggctgaa      240

gatgctgccg attattactg ccatcagtgg agtagttgga cgttcggtgg aggcacccag      300

ctggaaatca aa                                                          312


<210>  129
<211>  339
<212>  DNA
<213>  mus musculus

<400>  129
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ttacttgacc      120

tggtaccagc agaaaccagg acagcctcct aaactgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      240

attagcaatg tgcagcctga agacctggca gtttattact gtcagaatga ttatagtttt      300

ccattcacgt tcggctcggg gacagagttg gaaatgaaa                             339


<210>  130
<211>  336
<212>  DNA
<213>  mus musculus

<400>  130
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  131
<211>  336
<212>  DNA
<213>  mus musculus

<400>  131
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtct gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

atcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttcca      300

ttcacgttcg gctcggggac aaagttggaa gtaaaa                                336


<210>  132
<211>  336
<212>  DNA
<213>  mus musculus

<400>  132
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gaaacaccta tttagaatgg      120

tacctacaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  133
<211>  345
<212>  DNA
<213>  mus musculus

<400>  133
gaggttcagc tgcagcagtc tggggctgaa cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggatgc attgatcctg agaatggtga tactgaatat      180

gcctcgaaat tccaggacaa ggccactata acaacagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtac tacatacgtt      300

ggatttgctt actggggcca agggactctg gtcactgtct ctaca                      345


<210>  134
<211>  345
<212>  DNA
<213>  mus musculus

<400>  134
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcata agctatggta taacctgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag attcatccta gaagtggtaa tacttactac      180

aatgagaatt tcaaggacag ggcctcactg actgcagaca aatcctccag cacagcgtac      240

atggaggtcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aaggggtggg      300

ccgggggact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  135
<211>  345
<212>  DNA
<213>  mus musculus

<400>  135
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca agctatggta taagctgggt gaagcagaga      120

actggacagg gccttgagtg gattggacag atttatccta gaagtgacaa tacttactac      180

aatgagaggt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggcgctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagagagggg      300

ggtcccgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  136
<211>  345
<212>  DNA
<213>  mus musculus

<400>  136
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggatgc attgatcctg agaatggtga tattgaatat      180

gcctcgaggt tccagggcaa ggccactatg acagcagaca catcctccaa cacagcctac      240

ctgcagctca ccagcctgac atctgcggac actgccgtct attactgtac tacatacgtt      300

ggatttggtt actggggcca agggactctg gtcactgtct ctgca                      345


<210>  137
<211>  345
<212>  DNA
<213>  mus musculus

<400>  137
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggatgt attgatcctg agaatggtga tactgaatat      180

gcctcgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagtctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtac tacatacgtt      300

ggatttggtt actggggcca ggggactctg gtcactgtct ctgca                      345


<210>  138
<211>  342
<212>  DNA
<213>  mus musculus

<400>  138
caggtccaac tgaagcagtc tggggctgaa ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaggg cttctggcta cactttcact gacttctaca taaactgggt gaagcagagg      120

cctggacagg gacttgagtg gattgcaagg atttatcctg gaagtgatga gacttactac      180

aatgagaagt ttaaggacaa ggtcacactg actgcagaaa aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgaggac tctgctgtct atttctgtgc cctctggttc      300

ttcgatgtct ggggcacagg gaccacggtc accgtctcct ca                         342


<210>  139
<211>  345
<212>  DNA
<213>  mus musculus

<400>  139
caggttcagc tgcagcagtc tggagctgag ttggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttcgggcta caccttcaca agcgatggta ttacctgggt gaagcagaga      120

actggacagg gccttgagtg gattggacag attcatccta gaagtggtaa tacctactac      180

aatgggaagt tcaagggcaa ggccacactg actgcagaca gatcctccag cacaacgtac      240

atggaactcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aaaaactggg      300

acgggggact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  140
<211>  345
<212>  DNA
<213>  mus musculus

<400>  140
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactagctac      180

aaccagaagt tcaaggacaa ggccacattg actgtaaaca agtcctccag cacagccttc      240

atggagctcc gcagcctggc atcggaggat tctgcagtct attactgtgc aaggtctgac      300

tgggaagact gctggggcca aggcaccact ctcacagtct cctca                      345


<210>  141
<211>  363
<212>  DNA
<213>  mus musculus

<400>  141
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaat tttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagac acgatggtag caataactac      180

aacccgtctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgat tactgaggac acagccacat attactgtgt aagagagatc      300

tatgatggtt cctccgggta cttcgatgtc tggggcacag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  142
<211>  342
<212>  DNA
<213>  mus musculus

<400>  142
caggtccagc tgaagcagtc tggggctgaa ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta cactttcact gactactata taaactgggt gaagcagagg      120

cctggacagg gacttgagtg gattgcaagg atttatcctg gaaatggtaa tactgactac      180

aatgagaagt tcaaggacaa ggccacactg actgcagaaa aatcctccac cactgcctac      240

atacaactca gcagtctgac atctgaggac tctgctgtct atttctgttg cctctggtac      300

ttcgatgtct ggggcacagg aaccacggtc accgtctcct ca                         342


<210>  143
<211>  345
<212>  DNA
<213>  mus musculus

<400>  143
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttcgggcta caccttcaca agcgacggta taacctggct gaaacagaga      120

actggacagg gccttgagtg gattggacag attcatccta gaagtggtaa tacctactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggaactcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aaaaactggg      300

acgggggact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  144
<211>  345
<212>  DNA
<213>  mus musculus

<400>  144
caggttcagc tgcagcagtc tgggcctgag ctggcgaggc ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca agctatggta taagctgggt gaagcaaaga      120

actggacagg gccttgagtg gattggacag attcatccta gaagtggtaa tacttactac      180

aatgagaact tcaagggcaa ggccacactg actgcagcca aatcctccag cacagcgtac      240

ctggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagagagggg      300

ggtcccgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  145
<211>  345
<212>  DNA
<213>  mus musculus

<400>  145
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggatgc attgatcctg agaatggtga tattgaatat      180

gcctcgaggt tccagggcaa ggccactatg acagcagaca catcctccaa cacagcctac      240

ctgcagctca ccagcctgac atctgcggac actgccgtct attactgtac tacatacgtt      300

ggatttggtt actggggcca agggactctg gtcactgtct ctgca                      345


<210>  146
<211>  16
<212>  PRT
<213>  mus musculus

<400>  146

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  147
<211>  17
<212>  PRT
<213>  mus musculus

<400>  147

Lys Ser Asn Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  148
<211>  16
<212>  PRT
<213>  mus musculus

<400>  148

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  149
<211>  11
<212>  PRT
<213>  mus musculus

<400>  149

Gln Ala Thr Gln Asp Ile Val Lys Asn Leu Asn 
1               5                   10      


<210>  150
<211>  10
<212>  PRT
<213>  mus musculus

<400>  150

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  151
<211>  17
<212>  PRT
<213>  mus musculus

<400>  151

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  152
<211>  16
<212>  PRT
<213>  mus musculus

<400>  152

Lys Ser Ser Leu Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  153
<211>  7
<212>  PRT
<213>  mus musculus

<400>  153

Leu Val Ser Glu Leu Asp Ser 
1               5           


<210>  154
<211>  7
<212>  PRT
<213>  mus musculus

<400>  154

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  155
<211>  7
<212>  PRT
<213>  mus musculus

<400>  155

Tyr Ala Thr Glu Leu Ala Glu 
1               5           


<210>  156
<211>  7
<212>  PRT
<213>  mus musculus

<400>  156

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  157
<211>  9
<212>  PRT
<213>  mus musculus

<400>  157

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  mus musculus

<400>  158

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  mus musculus

<400>  159

Leu Gln Phe Tyr Glu Phe Pro Tyr Thr 
1               5                   


<210>  160
<211>  7
<212>  PRT
<213>  mus musculus

<400>  160

His Gln Trp Ser Ser Trp Thr 
1               5           


<210>  161
<211>  9
<212>  PRT
<213>  mus musculus

<400>  161

Gln Asn Asp Tyr Ser Phe Pro Phe Thr 
1               5                   


<210>  162
<211>  5
<212>  PRT
<213>  mus musculus

<400>  162

Asp Asp Tyr Met His 
1               5   


<210>  163
<211>  5
<212>  PRT
<213>  mus musculus

<400>  163

Ser Tyr Gly Ile Thr 
1               5   


<210>  164
<211>  5
<212>  PRT
<213>  mus musculus

<400>  164

Ser Tyr Gly Ile Ser 
1               5   


<210>  165
<211>  5
<212>  PRT
<213>  mus musculus

<400>  165

Asp Phe Tyr Ile Asn 
1               5   


<210>  166
<211>  5
<212>  PRT
<213>  mus musculus

<400>  166

Ser Asp Gly Ile Thr 
1               5   


<210>  167
<211>  5
<212>  PRT
<213>  mus musculus

<400>  167

Asp Tyr Asn Met His 
1               5   


<210>  168
<211>  6
<212>  PRT
<213>  mus musculus

<400>  168

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  169
<211>  5
<212>  PRT
<213>  mus musculus

<400>  169

Asp Tyr Tyr Ile Asn 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  mus musculus

<400>  170

Cys Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  171
<211>  17
<212>  PRT
<213>  mus musculus

<400>  171

Glu Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  172
<211>  18
<212>  PRT
<213>  mus musculus

<400>  172

Gln Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  173
<211>  17
<212>  PRT
<213>  mus musculus

<400>  173

Cys Ile Asp Pro Glu Asn Gly Asp Ile Glu Tyr Ala Ser Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  17
<212>  PRT
<213>  mus musculus

<400>  174

Cys Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  17
<212>  PRT
<213>  mus musculus

<400>  175

Arg Ile Tyr Pro Gly Ser Asp Glu Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  176
<211>  17
<212>  PRT
<213>  mus musculus

<400>  176

Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  177
<211>  17
<212>  PRT
<213>  mus musculus

<400>  177

Tyr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  178
<211>  16
<212>  PRT
<213>  mus musculus

<400>  178

Tyr Ile Arg His Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  179
<211>  17
<212>  PRT
<213>  mus musculus

<400>  179

Arg Ile Tyr Pro Gly Asn Gly Asn Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  180
<211>  17
<212>  PRT
<213>  mus musculus

<400>  180

Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  181
<211>  17
<212>  PRT
<213>  mus musculus

<400>  181

Gln Ile His Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  182
<211>  6
<212>  PRT
<213>  mus musculus

<400>  182

Tyr Val Gly Phe Ala Tyr 
1               5       


<210>  183
<211>  6
<212>  PRT
<213>  mus musculus

<400>  183

Gly Gly Pro Gly Asp Tyr 
1               5       


<210>  184
<211>  6
<212>  PRT
<213>  mus musculus

<400>  184

Glu Gly Gly Pro Asp Tyr 
1               5       


<210>  185
<211>  6
<212>  PRT
<213>  mus musculus

<400>  185

Tyr Val Gly Phe Gly Tyr 
1               5       


<210>  186
<211>  5
<212>  PRT
<213>  mus musculus

<400>  186

Trp Phe Phe Asp Val 
1               5   


<210>  187
<211>  6
<212>  PRT
<213>  mus musculus

<400>  187

Thr Gly Thr Gly Asp Tyr 
1               5       


<210>  188
<211>  6
<212>  PRT
<213>  mus musculus

<400>  188

Ser Asp Trp Glu Asp Cys 
1               5       


<210>  189
<211>  15
<212>  PRT
<213>  mus musculus

<400>  189

Glu Ile Tyr Asp Gly Ser Ser Gly Tyr Phe Asp Val Trp Gly Thr 
1               5                   10                  15  


<210>  190
<211>  5
<212>  PRT
<213>  mus musculus

<400>  190

Trp Tyr Phe Asp Val 
1               5   


<210>  191
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  191

Ser Asn Tyr Glu Asn Leu 
1               5       


<210>  192
<211>  640
<212>  PRT
<213>  homo sapiens

<400>  192

Met Leu Asn Lys Met Thr Leu His Pro Gln Gln Ile Met Ile Gly Pro 
1               5                   10                  15      


Arg Phe Asn Arg Ala Leu Phe Asp Pro Leu Leu Val Val Leu Leu Ala 
            20                  25                  30          


Leu Gln Leu Leu Val Val Ala Gly Leu Val Arg Ala Gln Thr Cys Pro 
        35                  40                  45              


Ser Val Cys Ser Cys Ser Asn Gln Phe Ser Lys Val Ile Cys Val Arg 
    50                  55                  60                  


Lys Asn Leu Arg Glu Val Pro Asp Gly Ile Ser Thr Asn Thr Arg Leu 
65                  70                  75                  80  


Leu Asn Leu His Glu Asn Gln Ile Gln Ile Ile Lys Val Asn Ser Phe 
                85                  90                  95      


Lys His Leu Arg His Leu Glu Ile Leu Gln Leu Ser Arg Asn His Ile 
            100                 105                 110         


Arg Thr Ile Glu Ile Gly Ala Phe Asn Gly Leu Ala Asn Leu Asn Thr 
        115                 120                 125             


Leu Glu Leu Phe Asp Asn Arg Leu Thr Thr Ile Pro Asn Gly Ala Phe 
    130                 135                 140                 


Val Tyr Leu Ser Lys Leu Lys Glu Leu Trp Leu Arg Asn Asn Pro Ile 
145                 150                 155                 160 


Glu Ser Ile Pro Ser Tyr Ala Phe Asn Arg Ile Pro Ser Leu Arg Arg 
                165                 170                 175     


Leu Asp Leu Gly Glu Leu Lys Arg Leu Ser Tyr Ile Ser Glu Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Ser Asn Leu Arg Tyr Leu Asn Leu Ala Met Cys Asn 
        195                 200                 205             


Leu Arg Glu Ile Pro Asn Leu Thr Pro Leu Ile Lys Leu Asp Glu Leu 
    210                 215                 220                 


Asp Leu Ser Gly Asn His Leu Ser Ala Ile Arg Pro Gly Ser Phe Gln 
225                 230                 235                 240 


Gly Leu Met His Leu Gln Lys Leu Trp Met Ile Gln Ser Gln Ile Gln 
                245                 250                 255     


Val Ile Glu Arg Asn Ala Phe Asp Asn Leu Gln Ser Leu Val Glu Ile 
            260                 265                 270         


Asn Leu Ala His Asn Asn Leu Thr Leu Leu Pro His Asp Leu Phe Thr 
        275                 280                 285             


Pro Leu His His Leu Glu Arg Ile His Leu His His Asn Pro Trp Asn 
    290                 295                 300                 


Cys Asn Cys Asp Ile Leu Trp Leu Ser Trp Trp Ile Lys Asp Met Ala 
305                 310                 315                 320 


Pro Ser Asn Thr Ala Cys Cys Ala Arg Cys Asn Thr Pro Pro Asn Leu 
                325                 330                 335     


Lys Gly Arg Tyr Ile Gly Glu Leu Asp Gln Asn Tyr Phe Thr Cys Tyr 
            340                 345                 350         


Ala Pro Val Ile Val Glu Pro Pro Ala Asp Leu Asn Val Thr Glu Gly 
        355                 360                 365             


Met Ala Ala Glu Leu Lys Cys Arg Ala Ser Thr Ser Leu Thr Ser Val 
    370                 375                 380                 


Ser Trp Ile Thr Pro Asn Gly Thr Val Met Thr His Gly Ala Tyr Lys 
385                 390                 395                 400 


Val Arg Ile Ala Val Leu Ser Asp Gly Thr Leu Asn Phe Thr Asn Val 
                405                 410                 415     


Thr Val Gln Asp Thr Gly Met Tyr Thr Cys Met Val Ser Asn Ser Val 
            420                 425                 430         


Gly Asn Thr Thr Ala Ser Ala Thr Leu Asn Val Thr Ala Ala Thr Thr 
        435                 440                 445             


Thr Pro Phe Ser Tyr Phe Ser Thr Val Thr Val Glu Thr Met Glu Pro 
    450                 455                 460                 


Ser Gln Asp Glu Ala Arg Thr Thr Asp Asn Asn Val Gly Pro Thr Pro 
465                 470                 475                 480 


Val Val Asp Trp Glu Thr Thr Asn Val Thr Thr Ser Leu Thr Pro Gln 
                485                 490                 495     


Ser Thr Arg Ser Thr Glu Lys Thr Phe Thr Ile Pro Val Thr Asp Ile 
            500                 505                 510         


Asn Ser Gly Ile Pro Gly Ile Asp Glu Val Met Lys Thr Thr Lys Ile 
        515                 520                 525             


Ile Ile Gly Cys Phe Val Ala Ile Thr Leu Met Ala Ala Val Met Leu 
    530                 535                 540                 


Val Ile Phe Tyr Lys Met Arg Lys Gln His His Arg Gln Asn His His 
545                 550                 555                 560 


Ala Pro Thr Arg Thr Val Glu Ile Ile Asn Val Asp Asp Glu Ile Thr 
                565                 570                 575     


Gly Asp Thr Pro Met Glu Ser His Leu Pro Met Pro Ala Ile Glu His 
            580                 585                 590         


Glu His Leu Asn His Tyr Asn Ser Tyr Lys Ser Pro Phe Asn His Thr 
        595                 600                 605             


Thr Thr Val Asn Thr Ile Asn Ser Ile His Ser Ser Val His Glu Pro 
    610                 615                 620                 


Leu Leu Ile Arg Met Asn Ser Lys Asp Asn Val Gln Glu Thr Gln Ile 
625                 630                 635                 640 


<210>  193
<211>  486
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  193

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly 
                485     


<210>  194
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  194

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly 
465         


<210>  195
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  sybthetic construct

<400>  195

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  196
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  196

Lys Ala Ser Gln Asp Ile Asn Thr Tyr Leu Ser 
1               5                   10      


<210>  197
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  197

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Val Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  198
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  198

Lys Ala Ser Gln Asp Ile Asn Val Tyr Leu Ser 
1               5                   10      


<210>  199
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Gln Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  200
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  200

Lys Ala Ser Gln Asp Ile Gln Ser Tyr Leu Ser 
1               5                   10      


<210>  201
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Val Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  202
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  202

Arg Ala Asn Arg Leu Thr Ser 
1               5           


<210>  203
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Ser Gly Ser Asp Thr Met His Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  204
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  204

Ser Tyr Trp Ile Thr 
1               5   


<210>  205
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  205

Asp Ile Tyr Ser Gly Ser Asp Thr Met His Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  206
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  206

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Ser Gly Ser Asp Thr Thr His Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  207
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  207

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Ser Gly Ser Asp Thr Thr His Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  208
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  208

Ser Tyr Trp Ile Ser 
1               5   


<210>  209
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  210
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  211
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  211

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  212
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  212

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Val Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  213
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  213

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Ala Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  214
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  214

Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Ala Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  215
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  215

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  216
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  216

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Trp Ser Glu Gly Ser Thr Thr Tyr Ala Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Pro Tyr Asp Asp Tyr Ser Gly Tyr Tyr Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  217
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  217

Leu Ile Trp Ser Glu Gly Ser Thr Thr Tyr Ala Ser Ala Leu Lys Ser 
1               5                   10                  15      


