                         SEQUENCE LISTING

<110>  Weiner, David
       Duperret, Elizabeth
        
<120>  OPTIMIZED SYNTHETIC CONSENSUS IMMUNOGENIC COMPOSITIONS TARGETING 
       FIBROBLAST ACTIVATION PROTEIN

<130>  206108-0068-00-WO.606652

<150>  US 62/397,469
<151>  2016-09-21

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  2202
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic consensus nucleotide sequence for human FAP

<400>  1
ctgaggcctt ctagagtgca caactccgag ggcccaacca gagccctgac actgaaggac       60

atcctgaatg gcaccttttc ttacaagaca ttctttccca actggatctc tggccaggag      120

tatctgcacc agagcgccga taacaacatc atcctgtaca acatcgagac aggcgagagc      180

tacacaatcc tgtccaactc taccatgaag agcgtgaacg cctccaatta cggcctgagc      240

cctgacaggc agttcgccta cctggagtct gattatagca agctgtggag atactcctat      300

accgccacat accacatcta tgatctgatc aatggcgagt ttgtgcggga gaacgagctg      360

ccccgcccta tccagtacct gtgctggagc cccgtgggca gcaagctggc atacgtgtat      420

cagaacaata tctatctgaa gcagaggccc agggaccctc ccttccagat cacatccaac      480

ggcaaggaga ataagatctt taacggcatc cccgattggg tgtacgagga ggagatgctg      540

gccaccaagt atgccctgtg gtggagccct aatggcaagt tcctggccta cgccgagttt      600

aacgacacag atatcccagt gatcgcctat tcctactatg gcgacgagca gtacccccgg      660

accatcaata tcccatatcc caaggcagga gcaaagaacc caacagtgcg cgtgttcatc      720

atcgatacca catacccaga gcacgtggga ccaaaggagg tgcctgtgcc agccatgatc      780

gccagctccg actactactt cagctggctg acctgggtga cagatgagag gatctgtctg      840

cagtggctga agagaatcca gaacgtgagc gtgctgtcta tctgcgactt cagggaggat      900

tggaacacct gggactgtcc taagacacag gagcacatcg aggagagcag aaccggatgg      960

gccggcggct tcttcgtgag cacaccagtg ttctctagcg acgccatcag ctactataag     1020

atcttttccg acaaggatgg ctacaagcac atccactata tcaaggatac cgtggagaat     1080

gccatccaga tcacatctgg caagtgggag gccatcaaca tcttcagggt gacccaggac     1140

agcctgttct actcctctaa tgagtttgag ggctacccag gcaggagaaa catctataga     1200

atcagcatcg gctcctaccc acccagcaag aagtgcgtga cctgtcacct gcggaaggag     1260

aggtgccagt actatacagc cagcttttcc gattacgcca agtactatgc cctgatctgt     1320

tatggccccg gcatccctat ctccaccctg cacgacggcc ggacagatca ggagatcaag     1380

atcctggagg agaataagga gctggagaat gccctgaaga acatccagct gcctaaggag     1440

gagatcaaga agctggaggt ggacggcatc accctgtggt acaagatgat cctgcctcca     1500

cagttcgatc ggtctaagaa gtatcccctg ctgatccagg tgtacggcgg accttgctct     1560

cagagcgtgc gcagcgtgtt ttccatctct tggatctcct acctggcctc taaggagggc     1620

atcgtggtgg ccctggtgga cggaagggga accgccttcc agggcgataa gctgctgtac     1680

gccgtgtatc gcaagctggg cgtgtacgag gtggaggacc agatcacagc cgtgcggaag     1740

ttcatcgaga tgggctttat cgatgagaag aggatcgcaa tctggggatg ggcatacggc     1800

ggatatgtga gctccctggc cctggcatct ggaaccggcc tgttcaagtg tggcatcgcc     1860

gtggccccag tgtctagctg ggagtactat gcctccatct acaccgagag gttcatgggc     1920

ctgcccacaa agtccgacaa tctggagcac tataagaact ctaccgtgat ggccagggcc     1980

gagtacttca gaaacgtgga ttatctgctg atccacggca cagccgacga taatgtgcac     2040

ttccagaact ccgcccagat cgccaaggcc ctggtgaatg cccaggtgga ctttcaggcc     2100

atgtggtact ctgatcagaa ccacggcatc tctggcctga gcaccaagca cctgtatacc     2160

cacatgacac acttcctgaa gcagtgcttt agcctgtccg ac                        2202


<210>  2
<211>  734
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic consensus amino acid sequence for human FAP

<400>  2

Leu Arg Pro Ser Arg Val His Asn Ser Glu Gly Pro Thr Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Ile Leu Tyr Asn Ile Glu Thr Gly Glu Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Ser Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Ala Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr His Ile Tyr Asp Leu Ile Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Glu Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Arg Asp Pro Pro Phe Gln Ile Thr Ser Asn 
145                 150                 155                 160 


Gly Lys Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Thr Val Arg Val Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Glu His Val Gly Pro Lys Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Ile Cys Leu Gln Trp Leu Lys Arg Ile Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Asn Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Ser Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Ile Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Gly Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ser 
        515                 520                 525             


Ile Ser Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Ile Val Val Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Ser Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Ile Ser Gly Leu Ser Thr Lys His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 


<210>  3
<211>  2256
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic consensus nucleotide sequence for human FAP operably 
       linked to sequence encoding an IgE leader

<400>  3
atggactgga cctggattct gttcctggtg gcagcagcaa caagggtgca ctccctgagg       60

ccttctagag tgcacaactc cgagggccca accagagccc tgacactgaa ggacatcctg      120

aatggcacct tttcttacaa gacattcttt cccaactgga tctctggcca ggagtatctg      180

caccagagcg ccgataacaa catcatcctg tacaacatcg agacaggcga gagctacaca      240

atcctgtcca actctaccat gaagagcgtg aacgcctcca attacggcct gagccctgac      300

aggcagttcg cctacctgga gtctgattat agcaagctgt ggagatactc ctataccgcc      360

acataccaca tctatgatct gatcaatggc gagtttgtgc gggagaacga gctgccccgc      420

cctatccagt acctgtgctg gagccccgtg ggcagcaagc tggcatacgt gtatcagaac      480

aatatctatc tgaagcagag gcccagggac cctcccttcc agatcacatc caacggcaag      540

gagaataaga tctttaacgg catccccgat tgggtgtacg aggaggagat gctggccacc      600

aagtatgccc tgtggtggag ccctaatggc aagttcctgg cctacgccga gtttaacgac      660

acagatatcc cagtgatcgc ctattcctac tatggcgacg agcagtaccc ccggaccatc      720

aatatcccat atcccaaggc aggagcaaag aacccaacag tgcgcgtgtt catcatcgat      780

accacatacc cagagcacgt gggaccaaag gaggtgcctg tgccagccat gatcgccagc      840

tccgactact acttcagctg gctgacctgg gtgacagatg agaggatctg tctgcagtgg      900

ctgaagagaa tccagaacgt gagcgtgctg tctatctgcg acttcaggga ggattggaac      960

acctgggact gtcctaagac acaggagcac atcgaggaga gcagaaccgg atgggccggc     1020

ggcttcttcg tgagcacacc agtgttctct agcgacgcca tcagctacta taagatcttt     1080

tccgacaagg atggctacaa gcacatccac tatatcaagg ataccgtgga gaatgccatc     1140

cagatcacat ctggcaagtg ggaggccatc aacatcttca gggtgaccca ggacagcctg     1200

ttctactcct ctaatgagtt tgagggctac ccaggcagga gaaacatcta tagaatcagc     1260

atcggctcct acccacccag caagaagtgc gtgacctgtc acctgcggaa ggagaggtgc     1320

cagtactata cagccagctt ttccgattac gccaagtact atgccctgat ctgttatggc     1380

cccggcatcc ctatctccac cctgcacgac ggccggacag atcaggagat caagatcctg     1440

gaggagaata aggagctgga gaatgccctg aagaacatcc agctgcctaa ggaggagatc     1500

aagaagctgg aggtggacgg catcaccctg tggtacaaga tgatcctgcc tccacagttc     1560

gatcggtcta agaagtatcc cctgctgatc caggtgtacg gcggaccttg ctctcagagc     1620

gtgcgcagcg tgttttccat ctcttggatc tcctacctgg cctctaagga gggcatcgtg     1680

gtggccctgg tggacggaag gggaaccgcc ttccagggcg ataagctgct gtacgccgtg     1740

tatcgcaagc tgggcgtgta cgaggtggag gaccagatca cagccgtgcg gaagttcatc     1800

gagatgggct ttatcgatga gaagaggatc gcaatctggg gatgggcata cggcggatat     1860

gtgagctccc tggccctggc atctggaacc ggcctgttca agtgtggcat cgccgtggcc     1920

ccagtgtcta gctgggagta ctatgcctcc atctacaccg agaggttcat gggcctgccc     1980

acaaagtccg acaatctgga gcactataag aactctaccg tgatggccag ggccgagtac     2040

ttcagaaacg tggattatct gctgatccac ggcacagccg acgataatgt gcacttccag     2100

aactccgccc agatcgccaa ggccctggtg aatgcccagg tggactttca ggccatgtgg     2160

tactctgatc agaaccacgg catctctggc ctgagcacca agcacctgta tacccacatg     2220

acacacttcc tgaagcagtg ctttagcctg tccgac                               2256


<210>  4
<211>  752
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic consensus amino acid sequence for human FAP operably 
       linked to an IgE leader sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Leu Arg Pro Ser Arg Val His Asn Ser Glu Gly Pro Thr Arg 
            20                  25                  30          


Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr 
        35                  40                  45              


Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala 
    50                  55                  60                  


Asp Asn Asn Ile Ile Leu Tyr Asn Ile Glu Thr Gly Glu Ser Tyr Thr 
65                  70                  75                  80  


Ile Leu Ser Asn Ser Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly 
                85                  90                  95      


Leu Ser Pro Asp Arg Gln Phe Ala Tyr Leu Glu Ser Asp Tyr Ser Lys 
            100                 105                 110         


Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr His Ile Tyr Asp Leu Ile 
        115                 120                 125             


Asn Gly Glu Phe Val Arg Glu Asn Glu Leu Pro Arg Pro Ile Gln Tyr 
    130                 135                 140                 


Leu Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn 
145                 150                 155                 160 


Asn Ile Tyr Leu Lys Gln Arg Pro Arg Asp Pro Pro Phe Gln Ile Thr 
                165                 170                 175     


Ser Asn Gly Lys Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val 
            180                 185                 190         


Tyr Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro 
        195                 200                 205             


Asn Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro 
    210                 215                 220                 


Val Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile 
225                 230                 235                 240 


Asn Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Thr Val Arg Val 
                245                 250                 255     


Phe Ile Ile Asp Thr Thr Tyr Pro Glu His Val Gly Pro Lys Glu Val 
            260                 265                 270         


Pro Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu 
        275                 280                 285             


Thr Trp Val Thr Asp Glu Arg Ile Cys Leu Gln Trp Leu Lys Arg Ile 
    290                 295                 300                 


Gln Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Asn 
305                 310                 315                 320 


Thr Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr 
                325                 330                 335     


Gly Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Ser Asp 
            340                 345                 350         


Ala Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His 
        355                 360                 365             


Ile His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser 
    370                 375                 380                 


Gly Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu 
385                 390                 395                 400 


Phe Tyr Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile 
                405                 410                 415     


Tyr Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr 
            420                 425                 430         


Cys His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser 
        435                 440                 445             


Asp Tyr Ala Lys Tyr Tyr Ala Leu Ile Cys Tyr Gly Pro Gly Ile Pro 
    450                 455                 460                 


Ile Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu 
465                 470                 475                 480 


Glu Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro 
                485                 490                 495     


Lys Glu Glu Ile Lys Lys Leu Glu Val Asp Gly Ile Thr Leu Trp Tyr 
            500                 505                 510         


Lys Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu 
        515                 520                 525             


Leu Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val 
    530                 535                 540                 


Phe Ser Ile Ser Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Ile Val 
545                 550                 555                 560 


Val Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu 
                565                 570                 575     


Leu Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln 
            580                 585                 590         


Ile Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys 
        595                 600                 605             


Arg Ile Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser Leu 
    610                 615                 620                 


Ala Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala 
625                 630                 635                 640 


Pro Val Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Thr Glu Arg Phe 
                645                 650                 655     


Met Gly Leu Pro Thr Lys Ser Asp Asn Leu Glu His Tyr Lys Asn Ser 
            660                 665                 670         


Thr Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu 
        675                 680                 685             


Ile His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln 
    690                 695                 700                 


Ile Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp 
705                 710                 715                 720 


Tyr Ser Asp Gln Asn His Gly Ile Ser Gly Leu Ser Thr Lys His Leu 
                725                 730                 735     


Tyr Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
            740                 745                 750         


<210>  5
<211>  2205
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic consensus nucleotide sequence for mouse FAP

<400>  5
ctgcggcctt cccgcgtgta caagccagag ggcaacacca agcgcgccct gacactgaag       60

gatatcctga acggaacctt cagctacaag acattctttc ccaactggat ctccggccag      120

gagtacctgc accagtctga ggacgataac atcgtgtttt acaacatcga gacaggagag      180

tcctacatca tcctgtccaa ctctacaatg aagtctgtga acgctagcga ctacggcctg      240

tctcctgata ggcagttcgt gtacctggag agcgactact ccaagctgtg gagatacagc      300

tacaccgcca catactacat ctacgatctg cagaacggcg agtttgtgag gggatacgag      360

ctgcccagac ctatccagta cctgtgctgg tcccctgtgg gatctaagct ggcctacgtg      420

taccagaaca acatctacct gaagcagcgg ccaggcgacc ctcccttcca gatcacctac      480

aacggccgcg agaacaagat ctttaacgga atccccgatt gggtgtacga ggaggagatg      540

ctggctacaa agtacgccct gtggtggagc cccaacggca agttcctggc ttacgccgag      600

tttaacgaca ccgatatccc agtgatcgcc tacagctact acggcgacgg acagtacccc      660

aggacaatca acatcccata ccccaaggct ggagccaaga accccgtggt gagagtgttc      720

atcgtggata ccacataccc acaccacgtg ggaccaatgg aggtgcctgt gccagagatg      780

atcgctagct ccgactacta ctttagctgg ctgacctggg tgacagatga gagggtgtgc      840

ctgcagtggc tgaagcgcgt gcagaacgtg tctgtgctga gcatctgcga cttcagggag      900

gattggcacg cctgggagtg tcctaagaac caggagcacg tggaggagtc cagaaccgga      960

tgggccggcg gcttcttcgt gagcacacca gtgttcagcc aggacgccat ctcctactac     1020

aagatctttt ctgacaagga tggatacaag cacatccact acatcaagga taccgtggag     1080

aacgctatcc agatcacaag cggcaagtgg gaggccatct acatcttccg ggtgacccag     1140

gactccctgt tctactctag caacgagttt gagggctacc caggaaggag aaacatctac     1200

cgcatctcta tcggctcctc tccacccagc aagaagtgcg tgacctgtca cctgaggaag     1260

gagagatgcc agtactacac agctagcttt tccgactacg ctaagtacta cgctctggtg     1320

tgctacggac caggactgcc tatctccacc ctgcacgacg gaagaacaga tcaggagatc     1380

aagatcctgg aggagaacaa ggagctggag aacgccctga agaacatcca gctgcccaag     1440

gaggagatca agaagctgga ggtggacggc atcaccctgt ggtacaagat gatcctgcct     1500

ccacagttcg atcggtccaa gaagtacccc ctgctgatcc aggtgtacgg cggaccttgc     1560

tctcagagcg tgaagagcgt gttcgctgtg aactggatca gctacctggc ctccaaggag     1620

ggcatcgtga tcgctctggt ggacggaagg ggaaccgctt tccagggcga taagtttctg     1680

tacgccgtgt accgcaagct gggagtgtac gaggtggagg accagatcac agccgtgagg     1740

aagttcatcg agatgggctt tatcgatgag aagagaatcg ctatctgggg atgggcctac     1800

ggcggatacg tgagctccct ggctctggct tccggaaccg gactgttcaa gtgtggaatc     1860

gctgtggccc cagtgtctag ctgggagtac tacgcctcta tctacaccga gaggtttatg     1920

ggcctgccca caaaggacga taacctggag cactacaaga acagcaccgt gatggctcgg     1980

gccgagtact tccgcaacgt ggactacctg ctgatccacg gaacagctga cgataacgtg     2040

cacttccaga acagcgccca gatcgctaag gccctggtga acgctcaggt ggactttcag     2100

gccatgtggt actccgatca gaaccacggc atctccggcg gatctacaaa ccacctgtac     2160

acccacatga cacacttcct gaagcagtgc ttttccctgt ctgac                     2205


<210>  6
<211>  735
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic consensus amino acid sequence for mouse FAP

<400>  6

Leu Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala 
1               5                   10                  15      


Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe 
            20                  25                  30          


Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Glu Asp 
        35                  40                  45              


Asp Asn Ile Val Phe Tyr Asn Ile Glu Thr Gly Glu Ser Tyr Ile Ile 
    50                  55                  60                  


Leu Ser Asn Ser Thr Met Lys Ser Val Asn Ala Ser Asp Tyr Gly Leu 
65                  70                  75                  80  


Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe 
225                 230                 235                 240 


Ile Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro 
                245                 250                 255     


Val Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala 
    290                 295                 300                 


Trp Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Gln Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Ser Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Gly Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Ile Ser Gly Gly Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  7
<211>  2259
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic consensus nucleotide sequence for mouse FAP operably 
       linked to sequence encoding an IgE leader

<400>  7
atggactgga cctggattct gttcctggtg gctgctgcta cacgggtgca cagcctgcgg       60

ccttcccgcg tgtacaagcc agagggcaac accaagcgcg ccctgacact gaaggatatc      120

ctgaacggaa ccttcagcta caagacattc tttcccaact ggatctccgg ccaggagtac      180

ctgcaccagt ctgaggacga taacatcgtg ttttacaaca tcgagacagg agagtcctac      240

atcatcctgt ccaactctac aatgaagtct gtgaacgcta gcgactacgg cctgtctcct      300

gataggcagt tcgtgtacct ggagagcgac tactccaagc tgtggagata cagctacacc      360

gccacatact acatctacga tctgcagaac ggcgagtttg tgaggggata cgagctgccc      420

agacctatcc agtacctgtg ctggtcccct gtgggatcta agctggccta cgtgtaccag      480

aacaacatct acctgaagca gcggccaggc gaccctccct tccagatcac ctacaacggc      540

cgcgagaaca agatctttaa cggaatcccc gattgggtgt acgaggagga gatgctggct      600

acaaagtacg ccctgtggtg gagccccaac ggcaagttcc tggcttacgc cgagtttaac      660

gacaccgata tcccagtgat cgcctacagc tactacggcg acggacagta ccccaggaca      720

atcaacatcc cataccccaa ggctggagcc aagaaccccg tggtgagagt gttcatcgtg      780

gataccacat acccacacca cgtgggacca atggaggtgc ctgtgccaga gatgatcgct      840

agctccgact actactttag ctggctgacc tgggtgacag atgagagggt gtgcctgcag      900

tggctgaagc gcgtgcagaa cgtgtctgtg ctgagcatct gcgacttcag ggaggattgg      960

cacgcctggg agtgtcctaa gaaccaggag cacgtggagg agtccagaac cggatgggcc     1020

ggcggcttct tcgtgagcac accagtgttc agccaggacg ccatctccta ctacaagatc     1080

ttttctgaca aggatggata caagcacatc cactacatca aggataccgt ggagaacgct     1140

atccagatca caagcggcaa gtgggaggcc atctacatct tccgggtgac ccaggactcc     1200

ctgttctact ctagcaacga gtttgagggc tacccaggaa ggagaaacat ctaccgcatc     1260

tctatcggct cctctccacc cagcaagaag tgcgtgacct gtcacctgag gaaggagaga     1320

tgccagtact acacagctag cttttccgac tacgctaagt actacgctct ggtgtgctac     1380

ggaccaggac tgcctatctc caccctgcac gacggaagaa cagatcagga gatcaagatc     1440

ctggaggaga acaaggagct ggagaacgcc ctgaagaaca tccagctgcc caaggaggag     1500

atcaagaagc tggaggtgga cggcatcacc ctgtggtaca agatgatcct gcctccacag     1560

ttcgatcggt ccaagaagta ccccctgctg atccaggtgt acggcggacc ttgctctcag     1620

agcgtgaaga gcgtgttcgc tgtgaactgg atcagctacc tggcctccaa ggagggcatc     1680

gtgatcgctc tggtggacgg aaggggaacc gctttccagg gcgataagtt tctgtacgcc     1740

gtgtaccgca agctgggagt gtacgaggtg gaggaccaga tcacagccgt gaggaagttc     1800

atcgagatgg gctttatcga tgagaagaga atcgctatct ggggatgggc ctacggcgga     1860

tacgtgagct ccctggctct ggcttccgga accggactgt tcaagtgtgg aatcgctgtg     1920

gccccagtgt ctagctggga gtactacgcc tctatctaca ccgagaggtt tatgggcctg     1980

cccacaaagg acgataacct ggagcactac aagaacagca ccgtgatggc tcgggccgag     2040

tacttccgca acgtggacta cctgctgatc cacggaacag ctgacgataa cgtgcacttc     2100

cagaacagcg cccagatcgc taaggccctg gtgaacgctc aggtggactt tcaggccatg     2160

tggtactccg atcagaacca cggcatctcc ggcggatcta caaaccacct gtacacccac     2220

atgacacact tcctgaagca gtgcttttcc ctgtctgac                            2259


<210>  8
<211>  753
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic consensus amino acid sequence for mouse FAP operably 
       linked to an IgE leader sequence

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Leu Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys 
            20                  25                  30          


Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys 
        35                  40                  45              


Thr Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser 
    50                  55                  60                  


Glu Asp Asp Asn Ile Val Phe Tyr Asn Ile Glu Thr Gly Glu Ser Tyr 
65                  70                  75                  80  


Ile Ile Leu Ser Asn Ser Thr Met Lys Ser Val Asn Ala Ser Asp Tyr 
                85                  90                  95      


Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser 
            100                 105                 110         


Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu 
        115                 120                 125             


Gln Asn Gly Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln 
    130                 135                 140                 


Tyr Leu Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln 
145                 150                 155                 160 


Asn Asn Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile 
                165                 170                 175     


Thr Tyr Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp 
            180                 185                 190         


Val Tyr Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser 
        195                 200                 205             


Pro Asn Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile 
    210                 215                 220                 


Pro Val Ile Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr 
225                 230                 235                 240 


Ile Asn Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg 
                245                 250                 255     


Val Phe Ile Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu 
            260                 265                 270         


Val Pro Val Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp 
        275                 280                 285             


Leu Thr Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg 
    290                 295                 300                 


Val Gln Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp 
305                 310                 315                 320 


His Ala Trp Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg 
                325                 330                 335     


Thr Gly Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Gln 
            340                 345                 350         


Asp Ala Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys 
        355                 360                 365             


His Ile His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr 
    370                 375                 380                 


Ser Gly Lys Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser 
385                 390                 395                 400 


Leu Phe Tyr Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn 
                405                 410                 415     


Ile Tyr Arg Ile Ser Ile Gly Ser Ser Pro Pro Ser Lys Lys Cys Val 
            420                 425                 430         


Thr Cys His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe 
        435                 440                 445             


Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu 
    450                 455                 460                 


Pro Ile Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile 
465                 470                 475                 480 


Leu Glu Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu 
                485                 490                 495     


Pro Lys Glu Glu Ile Lys Lys Leu Glu Val Asp Gly Ile Thr Leu Trp 
            500                 505                 510         


Tyr Lys Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro 
        515                 520                 525             


Leu Leu Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser 
    530                 535                 540                 


Val Phe Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Ile 
545                 550                 555                 560 


Val Ile Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys 
                565                 570                 575     


Phe Leu Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp 
            580                 585                 590         


Gln Ile Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu 
        595                 600                 605             


Lys Arg Ile Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser 
    610                 615                 620                 


Leu Ala Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val 
625                 630                 635                 640 


Ala Pro Val Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Thr Glu Arg 
                645                 650                 655     


Phe Met Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn 
            660                 665                 670         


Ser Thr Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu 
        675                 680                 685             


Leu Ile His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala 
    690                 695                 700                 


Gln Ile Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met 
705                 710                 715                 720 


Trp Tyr Ser Asp Gln Asn His Gly Ile Ser Gly Gly Ser Thr Asn His 
                725                 730                 735     


Leu Tyr Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser 
            740                 745                 750         


Asp 
    


<210>  9
<211>  2208
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Native nucleotide sequence for mouse FAP

<400>  9
ctgcggcctt ctcgcgtgta caagccagag ggcaacacca agcgcgctct gacactgaag       60

gatatcctga acggaacctt ctcttacaag acatactttc ccaactggat ctctgagcag      120

gagtacctgc accagagcga ggacgataac atcgtgtttt acaacatcga gacaagggag      180

agctacatca tcctgagcaa ctccaccatg aagagcgtga acgctacaga ctacggcctg      240

tcccctgata ggcagttcgt gtacctggag tctgactaca gcaagctgtg gagatactcc      300

tacaccgcca catactacat ctacgatctg cagaacggcg agtttgtgcg gggatacgag      360

ctgccccgcc ctatccagta cctgtgctgg agccctgtgg gctccaagct ggcctacgtg      420

taccagaaca acatctacct gaagcagagg cccggcgacc ctcccttcca gatcacctac      480

acaggcaggg agaacagaat ctttaacgga atccccgact gggtgtacga ggaggagatg      540

ctggctacca agtacgccct gtggtggtcc cctgatggca agttcctggc ttacgtggag      600

tttaacgact ccgatatccc aatcatcgcc tactcttact acggcgatgg acagtacccc      660

aggacaatca acatcccata ccccaaggct ggcgccaaga accccgtggt gagagtgttc      720

atcgtggaca ccacataccc acaccacgtg ggacccatgg aggtgcctgt gccagagatg      780

atcgccagct ccgattacta cttttcttgg ctgacctggg tgtctagcga gagggtgtgc      840

ctgcagtggc tgaagagagt gcagaacgtg tccgtgctgt ctatctgcga cttcagggag      900

gattggcacg cttgggagtg tcctaagaac caggagcacg tggaggagtc cagaacagga      960

tgggccggcg gcttcttcgt gagcacccca gctttcagcc aggacgccac atcctactac     1020

aagatctttt ctgacaagga tggctacaag cacatccact acatcaagga taccgtggag     1080

aacgctatcc agatcacaag cggaaagtgg gaggccatct acatcttcag ggtgacccag     1140

gactccctgt tctactcctc taacgagttt gagggctacc caggaaggag aaacatctac     1200

agaatctcca tcggcaacag cccaccctcc aagaagtgcg tgacctgtca cctgcggaag     1260

gagaggtgcc agtactacac agcctctttt agctacaagg ctaagtacta cgctctggtg     1320

tgctacggac caggactgcc tatctctacc ctgcacgacg gacggacaga tcaggagatc     1380

caggtgctgg aggagaacaa ggagctggag aacagcctgc gcaacatcca gctgcccaag     1440

gtggagatca agaagctgaa ggacggcgga ctgacattct ggtacaagat gatcctgcct     1500

ccacagtttg ataggagcaa gaagtacccc ctgctgatcc aggtgtacgg cggaccttgc     1560

tcccagtctg tgaagtccgt gttcgctgtg aactggatca cctacctggc ctctaaggag     1620

ggcatcgtga tcgctctggt ggacggaagg ggaacagctt tccagggcga taagtttctg     1680

cacgccgtgt accgcaagct gggagtgtac gaggtggagg accagctgac cgccgtgcgg     1740

aagttcatcg agatgggctt tatcgatgag gagcgcatcg ctatctgggg atgggcctac     1800

ggcggatacg tgagctccct ggctctggct agcggaacag gactgttcaa gtgtggcatc     1860

gctgtggccc cagtgtctag ctgggagtac tacgcctcta tctacagcga gcggtttatg     1920

ggactgccca ccaaggacga taacctggag cactacaaga acagcacagt gatggctagg     1980

gccgagtact tcagaaacgt ggactacctg ctgatccacg gcaccgctga cgataacgtg     2040

cacttccaga actccgccca gatcgctaag gccctggtga acgctcaggt ggactttcag     2100

gccatgtggt actctgatca gaaccacggc atctcctctg gacgcagcca gaaccacctg     2160

tacacccaca tgacacactt cctgaagcag tgctttagcc tgtccgac                  2208


<210>  10
<211>  736
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Native amino acid sequence for mouse FAP

<400>  10

Leu Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala 
1               5                   10                  15      


Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Tyr 
            20                  25                  30          


Phe Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser Glu Asp 
        35                  40                  45              


Asp Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile 
    50                  55                  60                  


Leu Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr Gly Leu 
65                  70                  75                  80  


Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr 
145                 150                 155                 160 


Thr Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asp 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile Pro Ile 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe 
225                 230                 235                 240 


Ile Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro 
                245                 250                 255     


Val Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala 
    290                 295                 300                 


Trp Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln Asp Ala 
                325                 330                 335     


Thr Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr 
            420                 425                 430         


Lys Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Val Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu 
545                 550                 555                 560 


His Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Ile Ser Ser Gly Arg Ser Gln Asn His Leu 
705                 710                 715                 720 


Tyr Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735     


<210>  11
<211>  2262
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleotide sequence for native mouse FAP operably linked to an 
       IgE leader sequence

<400>  11
atggactgga cctggattct gttcctggtg gctgctgcta cacgggtgca ctccctgcgg       60

ccttctcgcg tgtacaagcc agagggcaac accaagcgcg ctctgacact gaaggatatc      120

ctgaacggaa ccttctctta caagacatac tttcccaact ggatctctga gcaggagtac      180

ctgcaccaga gcgaggacga taacatcgtg ttttacaaca tcgagacaag ggagagctac      240

atcatcctga gcaactccac catgaagagc gtgaacgcta cagactacgg cctgtcccct      300

gataggcagt tcgtgtacct ggagtctgac tacagcaagc tgtggagata ctcctacacc      360

gccacatact acatctacga tctgcagaac ggcgagtttg tgcggggata cgagctgccc      420

cgccctatcc agtacctgtg ctggagccct gtgggctcca agctggccta cgtgtaccag      480

aacaacatct acctgaagca gaggcccggc gaccctccct tccagatcac ctacacaggc      540

agggagaaca gaatctttaa cggaatcccc gactgggtgt acgaggagga gatgctggct      600

accaagtacg ccctgtggtg gtcccctgat ggcaagttcc tggcttacgt ggagtttaac      660

gactccgata tcccaatcat cgcctactct tactacggcg atggacagta ccccaggaca      720

atcaacatcc cataccccaa ggctggcgcc aagaaccccg tggtgagagt gttcatcgtg      780

gacaccacat acccacacca cgtgggaccc atggaggtgc ctgtgccaga gatgatcgcc      840

agctccgatt actacttttc ttggctgacc tgggtgtcta gcgagagggt gtgcctgcag      900

tggctgaaga gagtgcagaa cgtgtccgtg ctgtctatct gcgacttcag ggaggattgg      960

cacgcttggg agtgtcctaa gaaccaggag cacgtggagg agtccagaac aggatgggcc     1020

ggcggcttct tcgtgagcac cccagctttc agccaggacg ccacatccta ctacaagatc     1080

ttttctgaca aggatggcta caagcacatc cactacatca aggataccgt ggagaacgct     1140

atccagatca caagcggaaa gtgggaggcc atctacatct tcagggtgac ccaggactcc     1200

ctgttctact cctctaacga gtttgagggc tacccaggaa ggagaaacat ctacagaatc     1260

tccatcggca acagcccacc ctccaagaag tgcgtgacct gtcacctgcg gaaggagagg     1320

tgccagtact acacagcctc ttttagctac aaggctaagt actacgctct ggtgtgctac     1380

ggaccaggac tgcctatctc taccctgcac gacggacgga cagatcagga gatccaggtg     1440

ctggaggaga acaaggagct ggagaacagc ctgcgcaaca tccagctgcc caaggtggag     1500

atcaagaagc tgaaggacgg cggactgaca ttctggtaca agatgatcct gcctccacag     1560

tttgatagga gcaagaagta ccccctgctg atccaggtgt acggcggacc ttgctcccag     1620

tctgtgaagt ccgtgttcgc tgtgaactgg atcacctacc tggcctctaa ggagggcatc     1680

gtgatcgctc tggtggacgg aaggggaaca gctttccagg gcgataagtt tctgcacgcc     1740

gtgtaccgca agctgggagt gtacgaggtg gaggaccagc tgaccgccgt gcggaagttc     1800

atcgagatgg gctttatcga tgaggagcgc atcgctatct ggggatgggc ctacggcgga     1860

tacgtgagct ccctggctct ggctagcgga acaggactgt tcaagtgtgg catcgctgtg     1920

gccccagtgt ctagctggga gtactacgcc tctatctaca gcgagcggtt tatgggactg     1980

cccaccaagg acgataacct ggagcactac aagaacagca cagtgatggc tagggccgag     2040

tacttcagaa acgtggacta cctgctgatc cacggcaccg ctgacgataa cgtgcacttc     2100

cagaactccg cccagatcgc taaggccctg gtgaacgctc aggtggactt tcaggccatg     2160

tggtactctg atcagaacca cggcatctcc tctggacgca gccagaacca cctgtacacc     2220

cacatgacac acttcctgaa gcagtgcttt agcctgtccg ac                        2262


<210>  12
<211>  754
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence for native mouse FAP operably linked to an 
       IgE leader sequence

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Leu Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys 
            20                  25                  30          


Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys 
        35                  40                  45              


Thr Tyr Phe Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser 
    50                  55                  60                  


Glu Asp Asp Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr 
65                  70                  75                  80  


Ile Ile Leu Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr 
                85                  90                  95      


Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser 
            100                 105                 110         


Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu 
        115                 120                 125             


Gln Asn Gly Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln 
    130                 135                 140                 


Tyr Leu Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln 
145                 150                 155                 160 


Asn Asn Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile 
                165                 170                 175     


Thr Tyr Thr Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp 
            180                 185                 190         


Val Tyr Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser 
        195                 200                 205             


Pro Asp Gly Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile 
    210                 215                 220                 


Pro Ile Ile Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr 
225                 230                 235                 240 


Ile Asn Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg 
                245                 250                 255     


Val Phe Ile Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu 
            260                 265                 270         


Val Pro Val Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp 
        275                 280                 285             


Leu Thr Trp Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg 
    290                 295                 300                 


Val Gln Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp 
305                 310                 315                 320 


His Ala Trp Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg 
                325                 330                 335     


Thr Gly Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln 
            340                 345                 350         


Asp Ala Thr Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys 
        355                 360                 365             


His Ile His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr 
    370                 375                 380                 


Ser Gly Lys Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser 
385                 390                 395                 400 


Leu Phe Tyr Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn 
                405                 410                 415     


Ile Tyr Arg Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val 
            420                 425                 430         


Thr Cys His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe 
        435                 440                 445             


Ser Tyr Lys Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu 
    450                 455                 460                 


Pro Ile Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val 
465                 470                 475                 480 


Leu Glu Glu Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu 
                485                 490                 495     


Pro Lys Val Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp 
            500                 505                 510         


Tyr Lys Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro 
        515                 520                 525             


Leu Leu Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser 
    530                 535                 540                 


Val Phe Ala Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile 
545                 550                 555                 560 


Val Ile Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys 
                565                 570                 575     


Phe Leu His Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp 
            580                 585                 590         


Gln Leu Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu 
        595                 600                 605             


Glu Arg Ile Ala Ile Trp Gly Trp Ala Tyr Gly Gly Tyr Val Ser Ser 
    610                 615                 620                 


Leu Ala Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val 
625                 630                 635                 640 


Ala Pro Val Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg 
                645                 650                 655     


Phe Met Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn 
            660                 665                 670         


Ser Thr Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu 
        675                 680                 685             


Leu Ile His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala 
    690                 695                 700                 


Gln Ile Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met 
705                 710                 715                 720 


Trp Tyr Ser Asp Gln Asn His Gly Ile Ser Ser Gly Arg Ser Gln Asn 
                725                 730                 735     


His Leu Tyr Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu 
            740                 745                 750         


Ser Asp 
        


<210>  13
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  13

Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met Ile Leu Pro Pro 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  14

Ala Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  15

Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala Leu Val Asp Gly 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  16

Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  17

His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  18

Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Ile 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  19

Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu Ser Asn Ser Thr 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  20

Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  21

Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly Glu Phe Val Arg 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  22

Glu Val Asp Gly Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  23

Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Ile Val 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Immunogenic Fragment of FAP

<400>  24

Asn Ile Glu Thr Gly Glu Ser Tyr Ile Ile Leu Ser Asn Ser Thr 
1               5                   10                  15  


