                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Compositions And Methods For Identification, Assessment, 
       Prevention, And Treatment Of AML Using USP10 Biomarkers And 
       Modulators

<130>  DFS-170.25

<140>  PCT/US2017/052506
<141>  2017-09-20

<150>  62/397,100
<151>  2016-09-20

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  3520
<212>  DNA
<213>  Homo sapiens

<400>  1
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta       60

tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg      120

agtcccaatg aaacgggcag ccatggccct ccacagcccg cagctcctgg gccatgatcc      180

cattttcatc agatgacttg agaacccaga agctctacca gcactgccat tctgtcccgt      240

cttgaaacat catgccctgg ttgccctctc ctggaatagg gcagtatatt tttggagatt      300

ttagccctga tgaattcaat caattctttg tgactcctcg atcttcagtt gagcttcctc      360

catacagtgg aacagttctg tgtggcacac aggctgtgga taaactacct gatggacaag      420

aatatcagag aattgagttt ggtgtcgatg aagtcattga acccagtgac actttgccga      480

gaacccccag ctacagtatt tcaagcacac tgaaccctca ggcccctgaa tttattctcg      540

gttgtacagc ttccaaaata acccctgatg gtatcactaa agaagcaagc tatggctcca      600

tcgactgcca gtacccaggc tctgccctcg ctttggatgg aagttctaat gtggaggcgg      660

aagttttgga aaatgatggt gtctcaggtg gtcttggaca aagggagcgt aaaaagaaga      720

aaaagcggcc acctggatat tacagctatt tgaaagatgg tggcgatgat agtatctcca      780

cagaagccct ggtcaatggc catgccaatt cagcagtccc gaacagtgtc agtgcagagg      840

atgcagaatt tatgggtgac atgcccccgt cagttacgcc caggacttgt aacagccccc      900

agaactccac agactctgtc agtgacattg tgcctgacag tcctttcccc ggagcactcg      960

gcagtgacac caggactgca gggcagccag aggggggccc cggggctgat tttggtcagt     1020

cctgcttccc tgcagaggct ggcagagaca ccctgtcaag gacagctggg gctcagccct     1080

gcgttggtac cgatactact gaaaaccttg gagttgctaa tggacaaata cttgaatcct     1140

cgggtgaggg cacagctacc aacggggtgg agttgcacac cacggaaagc atagacttgg     1200

acccaaccaa acccgagagt gcatcacctc ctgctgacgg cacgggctct gcatcaggca     1260

cccttcctgt cagccagccc aagtcctggg ccagcctctt tcatgattct aagccctctt     1320

cctcctcgcc ggtggcctat gtggaaacta agtattcccc tcccgccata tctcccctgg     1380

tttctgaaaa gcaggttgaa gtcaaagaag ggcttgttcc ggtttcagag gatcctgtag     1440

ccataaagat tgcagagttg ctggagaatg taaccctaat ccataaacca gtgtcgttgc     1500

aaccccgtgg gctgatcaat aaagggaact ggtgctacat taatgctaca ctgcaggcat     1560

tggttgcttg cccgccgatg taccacctga tgaagttcat tcctctgtat tccaaagtgc     1620

aaaggccttg tacgtcaaca cccatgatag acagctttgt tcggctaatg aatgagttca     1680

ctaatatgcc agtacctcca aaaccccgac aagctcttgg agataaaatc gtgagggata     1740

ttcgccctgg agctgccttt gagcccacat atatttacag actcctgaca gttaacaagt     1800

caagcctgtc tgaaaagggt cgacaagaag atgctgagga atacttaggc ttcattctaa     1860

atggacttca tgaggaaatg ttgaacctaa agaagcttct ctcaccaagt aatgaaaaac     1920

ttacgatttc caacggcccc aaaaaccact cggtcaatga agaagagcag gaagaacaag     1980

gtgaaggaag cgaggatgaa tgggaacaag tgggcccccg gaacaagact tccgtcaccc     2040

gccaggcgga ttttgttcag actccaatca ccggcatttt tggtggacac atcaggtctg     2100

tggtttacca gcagagttca aaagaatctg ccactttgca gccatttttc acgttgcagt     2160

tggatatcca gtcagacaag atacgcacag tccaggatgc actggagagc ttggtggcaa     2220

gagaatctgt ccaaggttat accacaaaaa ccaaacaaga ggttgagata agtcgaagag     2280

tgactctgga aaaactccct cctgtcctcg tgctgcacct gaaacgattc gtttatgaga     2340

agactggtgg gtgccagaag cttatcaaaa atattgaata tcctgtggac ttggaaatta     2400

gtaaagaact gctttctcca ggggttaaaa ataagaattt taaatgccac cgaacctatc     2460

ggctctttgc agtggtctac catcacggca acagtgcgac gggcggccat tacactacag     2520

acgtcttcca gatcggtctg aatggctggc tgcgcatcga tgaccagaca gtcaaggtga     2580

tcaaccagta ccaggtggtg aaaccaactg ctgaacgcac agcctacctc ctgtattacc     2640

gccgagtgga cctgctgtaa accctgtgtg cgctgtgtgt gcgcccagtg cccgcttcgt     2700

aggacaccac ctcacactca cttcccgcct ctctttagtg gctctttaga gagaaactct     2760

ttctcccttt gcaaaaatgg gctagaatga aaaggagatg ccttggggtt cgtgcacaac     2820

acagcttctg ttgactctaa cttccaaatc aaaatcattt ggttgaaaca gactgttgct     2880

tgattttaga aaatacacaa aaacccatat ttctgaaata atgctgattc ctgagataag     2940

aaagtggatt tgatccccag tctcattgct tagtagaata aatcctgcac cagcaacaac     3000

acttgtaaat ttgtgaaaat gaattttatc tttccttaaa aaagaaattt tttaatccat     3060

cacacttttc ttccctaccc tttagttttt gataaatgat aaaaatgagc cagttatcaa     3120

agaagaacta gttcttactt caaaagaaaa ataaacataa aaaataagtt gctggttcct     3180

aacaggaaaa attttaataa ttgtactgag agaaactgct tacgtacaca ttgcagatca     3240

aatatttgga gttaaaatgt tagtctacat agatgggtga ttgtaacttt attgccatta     3300

aaagatttca aattgcattc atgcttctgt gtacacataa tgaaaaatgg gcaaataatg     3360

aagatctctc cttcagtctg ctctgtttaa ttctgctgtc tgctcttctc taatgctgcg     3420

tccctaattg tacacagttt agtgatatct aggagtataa agttgtcgcc catcaataaa     3480

aatcacaaag ttggtttaaa aaaaaaaaaa aaaaaaaaaa                           3520


<210>  2
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Trp Leu Pro Ser Pro Gly Ile Gly Gln Tyr Ile Phe Gly Asp 
1               5                   10                  15      


Phe Ser Pro Asp Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser 
            20                  25                  30          


Val Glu Leu Pro Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala 
        35                  40                  45              


Val Asp Lys Leu Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly 
    50                  55                  60                  


Val Asp Glu Val Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser 
65                  70                  75                  80  


Tyr Ser Ile Ser Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu 
                85                  90                  95      


Gly Cys Thr Ala Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala 
            100                 105                 110         


Ser Tyr Gly Ser Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu 
        115                 120                 125             


Asp Gly Ser Ser Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val 
    130                 135                 140                 


Ser Gly Gly Leu Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro 
145                 150                 155                 160 


Pro Gly Tyr Tyr Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser 
                165                 170                 175     


Thr Glu Ala Leu Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser 
            180                 185                 190         


Val Ser Ala Glu Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val 
        195                 200                 205             


Thr Pro Arg Thr Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser 
    210                 215                 220                 


Asp Ile Val Pro Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr 
225                 230                 235                 240 


Arg Thr Ala Gly Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln 
                245                 250                 255     


Ser Cys Phe Pro Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala 
            260                 265                 270         


Gly Ala Gln Pro Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val 
        275                 280                 285             


Ala Asn Gly Gln Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn 
    290                 295                 300                 


Gly Val Glu Leu His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys 
305                 310                 315                 320 


Pro Glu Ser Ala Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly 
                325                 330                 335     


Thr Leu Pro Val Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp 
            340                 345                 350         


Ser Lys Pro Ser Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr 
        355                 360                 365             


Ser Pro Pro Ala Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val 
    370                 375                 380                 


Lys Glu Gly Leu Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile 
385                 390                 395                 400 


Ala Glu Leu Leu Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu 
                405                 410                 415     


Gln Pro Arg Gly Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala 
            420                 425                 430         


Thr Leu Gln Ala Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys 
        435                 440                 445             


Phe Ile Pro Leu Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro 
    450                 455                 460                 


Met Ile Asp Ser Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro 
465                 470                 475                 480 


Val Pro Pro Lys Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp 
                485                 490                 495     


Ile Arg Pro Gly Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu 
            500                 505                 510         


Thr Val Asn Lys Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala 
        515                 520                 525             


Glu Glu Tyr Leu Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu 
    530                 535                 540                 


Asn Leu Lys Lys Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser 
545                 550                 555                 560 


Asn Gly Pro Lys Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln 
                565                 570                 575     


Gly Glu Gly Ser Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys 
            580                 585                 590         


Thr Ser Val Thr Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly 
        595                 600                 605             


Ile Phe Gly Gly His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys 
    610                 615                 620                 


Glu Ser Ala Thr Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln 
625                 630                 635                 640 


Ser Asp Lys Ile Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala 
                645                 650                 655     


Arg Glu Ser Val Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu 
            660                 665                 670         


Ile Ser Arg Arg Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu 
        675                 680                 685             


His Leu Lys Arg Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu 
    690                 695                 700                 


Ile Lys Asn Ile Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu 
705                 710                 715                 720 


Leu Ser Pro Gly Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr 
                725                 730                 735     


Arg Leu Phe Ala Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly 
            740                 745                 750         


His Tyr Thr Thr Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg 
        755                 760                 765             


Ile Asp Asp Gln Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys 
    770                 775                 780                 


Pro Thr Ala Glu Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp 
785                 790                 795                 800 


Leu Leu 
        


<210>  3
<211>  3399
<212>  DNA
<213>  Homo sapiens

<400>  3
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta       60

tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg      120

agtcccaatg aaacgggcag ccatggccct ccacagcccg cagtatattt ttggagattt      180

tagccctgat gaattcaatc aattctttgt gactcctcga tcttcagttg agcttcctcc      240

atacagtgga acagttctgt gtggcacaca ggctgtggat aaactacctg atggacaaga      300

atatcagaga attgagtttg gtgtcgatga agtcattgaa cccagtgaca ctttgccgag      360

aacccccagc tacagtattt caagcacact gaaccctcag gcccctgaat ttattctcgg      420

ttgtacagct tccaaaataa cccctgatgg tatcactaaa gaagcaagct atggctccat      480

cgactgccag tacccaggct ctgccctcgc tttggatgga agttctaatg tggaggcgga      540

agttttggaa aatgatggtg tctcaggtgg tcttggacaa agggagcgta aaaagaagaa      600

aaagcggcca cctggatatt acagctattt gaaagatggt ggcgatgata gtatctccac      660

agaagccctg gtcaatggcc atgccaattc agcagtcccg aacagtgtca gtgcagagga      720

tgcagaattt atgggtgaca tgcccccgtc agttacgccc aggacttgta acagccccca      780

gaactccaca gactctgtca gtgacattgt gcctgacagt cctttccccg gagcactcgg      840

cagtgacacc aggactgcag ggcagccaga ggggggcccc ggggctgatt ttggtcagtc      900

ctgcttccct gcagaggctg gcagagacac cctgtcaagg acagctgggg ctcagccctg      960

cgttggtacc gatactactg aaaaccttgg agttgctaat ggacaaatac ttgaatcctc     1020

gggtgagggc acagctacca acggggtgga gttgcacacc acggaaagca tagacttgga     1080

cccaaccaaa cccgagagtg catcacctcc tgctgacggc acgggctctg catcaggcac     1140

ccttcctgtc agccagccca agtcctgggc cagcctcttt catgattcta agccctcttc     1200

ctcctcgccg gtggcctatg tggaaactaa gtattcccct cccgccatat ctcccctggt     1260

ttctgaaaag caggttgaag tcaaagaagg gcttgttccg gtttcagagg atcctgtagc     1320

cataaagatt gcagagttgc tggagaatgt aaccctaatc cataaaccag tgtcgttgca     1380

accccgtggg ctgatcaata aagggaactg gtgctacatt aatgctacac tgcaggcatt     1440

ggttgcttgc ccgccgatgt accacctgat gaagttcatt cctctgtatt ccaaagtgca     1500

aaggccttgt acgtcaacac ccatgataga cagctttgtt cggctaatga atgagttcac     1560

taatatgcca gtacctccaa aaccccgaca agctcttgga gataaaatcg tgagggatat     1620

tcgccctgga gctgcctttg agcccacata tatttacaga ctcctgacag ttaacaagtc     1680

aagcctgtct gaaaagggtc gacaagaaga tgctgaggaa tacttaggct tcattctaaa     1740

tggacttcat gaggaaatgt tgaacctaaa gaagcttctc tcaccaagta atgaaaaact     1800

tacgatttcc aacggcccca aaaaccactc ggtcaatgaa gaagagcagg aagaacaagg     1860

tgaaggaagc gaggatgaat gggaacaagt gggcccccgg aacaagactt ccgtcacccg     1920

ccaggcggat tttgttcaga ctccaatcac cggcattttt ggtggacaca tcaggtctgt     1980

ggtttaccag cagagttcaa aagaatctgc cactttgcag ccatttttca cgttgcagtt     2040

ggatatccag tcagacaaga tacgcacagt ccaggatgca ctggagagct tggtggcaag     2100

agaatctgtc caaggttata ccacaaaaac caaacaagag gttgagataa gtcgaagagt     2160

gactctggaa aaactccctc ctgtcctcgt gctgcacctg aaacgattcg tttatgagaa     2220

gactggtggg tgccagaagc ttatcaaaaa tattgaatat cctgtggact tggaaattag     2280

taaagaactg ctttctccag gggttaaaaa taagaatttt aaatgccacc gaacctatcg     2340

gctctttgca gtggtctacc atcacggcaa cagtgcgacg ggcggccatt acactacaga     2400

cgtcttccag atcggtctga atggctggct gcgcatcgat gaccagacag tcaaggtgat     2460

caaccagtac caggtggtga aaccaactgc tgaacgcaca gcctacctcc tgtattaccg     2520

ccgagtggac ctgctgtaaa ccctgtgtgc gctgtgtgtg cgcccagtgc ccgcttcgta     2580

ggacaccacc tcacactcac ttcccgcctc tctttagtgg ctctttagag agaaactctt     2640

tctccctttg caaaaatggg ctagaatgaa aaggagatgc cttggggttc gtgcacaaca     2700

cagcttctgt tgactctaac ttccaaatca aaatcatttg gttgaaacag actgttgctt     2760

gattttagaa aatacacaaa aacccatatt tctgaaataa tgctgattcc tgagataaga     2820

aagtggattt gatccccagt ctcattgctt agtagaataa atcctgcacc agcaacaaca     2880

cttgtaaatt tgtgaaaatg aattttatct ttccttaaaa aagaaatttt ttaatccatc     2940

acacttttct tccctaccct ttagtttttg ataaatgata aaaatgagcc agttatcaaa     3000

gaagaactag ttcttacttc aaaagaaaaa taaacataaa aaataagttg ctggttccta     3060

acaggaaaaa ttttaataat tgtactgaga gaaactgctt acgtacacat tgcagatcaa     3120

atatttggag ttaaaatgtt agtctacata gatgggtgat tgtaacttta ttgccattaa     3180

aagatttcaa attgcattca tgcttctgtg tacacataat gaaaaatggg caaataatga     3240

agatctctcc ttcagtctgc tctgtttaat tctgctgtct gctcttctct aatgctgcgt     3300

ccctaattgt acacagttta gtgatatcta ggagtataaa gttgtcgccc atcaataaaa     3360

atcacaaagt tggtttaaaa aaaaaaaaaa aaaaaaaaa                            3399


<210>  4
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210>  5
<211>  2297
<212>  DNA
<213>  Homo sapiens

<400>  5
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta       60

tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg      120

agtcccaatg aaacgggcag ccatggccct ccacagcccg cagtatattt ttggagattt      180

tagccctgat gaattcaatc aattctttgt gactcctcga tcttcagttg agagttgctg      240

gagaatgtaa ccctaatcca taaaccagtg tcgttgcaac cccgtgggct gatcaataaa      300

gggaactggt gctacattaa tgctacactg caggcattgg ttgcttgccc gccgatgtac      360

cacctgatga agttcattcc tctgtattcc aaagtgcaaa ggccttgtac gtcaacaccc      420

atgatagaca gctttgttcg gctaatgaat gagttcacta atatgccagt acctccaaaa      480

ccccgacaag ctcttggaga taaaatcgtg agggatattc gccctggagc tgcctttgag      540

cccacatata tttacagact cctgacagtt aacaagtcaa gcctgtctga aaagggtcga      600

caagaagatg ctgaggaata cttaggcttc attctaaatg gacttcatga ggaaatgttg      660

aacctaaaga agcttctctc accaagtaat gaaaaactta cgatttccaa cggccccaaa      720

aaccactcgg tcaatgaaga agagcaggaa gaacaaggtg aaggaagcga ggatgaatgg      780

gaacaagtgg gcccccggaa caagacttcc gtcacccgcc aggcggattt tgttcagact      840

ccaatcaccg gcatttttgg tggacacatc aggtctgtgg tttaccagca gagttcaaaa      900

gaatctgcca ctttgcagcc atttttcacg ttgcagttgg atatccagtc agacaagata      960

cgcacagtcc aggatgcact ggagagcttg gtggcaagag aatctgtcca aggttatacc     1020

acaaaaacca aacaagaggt tgagataagt cgaagagtga ctctggaaaa actccctcct     1080

gtcctcgtgc tgcacctgaa acgattcgtt tatgagaaga ctggtgggtg ccagaagctt     1140

atcaaaaata ttgaatatcc tgtggacttg gaaattagta aagaactgct ttctccaggg     1200

gttaaaaata agaattttaa atgccaccga acctatcggc tctttgcagt ggtctaccat     1260

cacggcaaca gtgcgacggg cggccattac actacagacg tcttccagat cggtctgaat     1320

ggctggctgc gcatcgatga ccagacagtc aaggtgatca accagtacca ggtggtgaaa     1380

ccaactgctg aacgcacagc ctacctcctg tattaccgcc gagtggacct gctgtaaacc     1440

ctgtgtgcgc tgtgtgtgcg cccagtgccc gcttcgtagg acaccacctc acactcactt     1500

cccgcctctc tttagtggct ctttagagag aaactctttc tccctttgca aaaatgggct     1560

agaatgaaaa ggagatgcct tggggttcgt gcacaacaca gcttctgttg actctaactt     1620

ccaaatcaaa atcatttggt tgaaacagac tgttgcttga ttttagaaaa tacacaaaaa     1680

cccatatttc tgaaataatg ctgattcctg agataagaaa gtggatttga tccccagtct     1740

cattgcttag tagaataaat cctgcaccag caacaacact tgtaaatttg tgaaaatgaa     1800

ttttatcttt ccttaaaaaa gaaatttttt aatccatcac acttttcttc cctacccttt     1860

agtttttgat aaatgataaa aatgagccag ttatcaaaga agaactagtt cttacttcaa     1920

aagaaaaata aacataaaaa ataagttgct ggttcctaac aggaaaaatt ttaataattg     1980

tactgagaga aactgcttac gtacacattg cagatcaaat atttggagtt aaaatgttag     2040

tctacataga tgggtgattg taactttatt gccattaaaa gatttcaaat tgcattcatg     2100

cttctgtgta cacataatga aaaatgggca aataatgaag atctctcctt cagtctgctc     2160

tgtttaattc tgctgtctgc tcttctctaa tgctgcgtcc ctaattgtac acagtttagt     2220

gatatctagg agtataaagt tgtcgcccat caataaaaat cacaaagttg gtttaaaaaa     2280

aaaaaaaaaa aaaaaaa                                                    2297


<210>  6
<211>  3136
<212>  DNA
<213>  Homo sapiens

<400>  6
ctccccgcgc cccgcggcgc gcggccagtg cgcaggcgcg gcggccgatg cgagtgtgta       60

tgtgcgggcg agaagatggc ggcggcgggg gaagcagcgt gagcagccgg aggatcgcgg      120

agtcccaatg aaacgggcag ccatggccct ccacagcccg cagtatattt ttggagattt      180

tagccctgat gaattcaatc aattctttgt gactcctcga tcttcagttg aggacaagaa      240

tatcagagaa ttgagtttgg tgtcgatgaa gtcattgaac ccagtgacac tttgccgaga      300

acccccagct acagtatttc aagcacactg aaccctcagg cccctgaatt tattctcggt      360

tgtacagctt ccaaaataac ccctgatggt atcactaaag aagcaagcta tggctccatc      420

gactgccagt acccaggctc tgccctcgct ttggatggaa gttctaatgt ggaggcggaa      480

gttttggaaa atgatggtgt ctcaggtggt cttggacaaa gggagcgtaa aaagaagaaa      540

aagcggccac ctggatatta cagctatttg aaagatggtg gcgatgatag tatctccaca      600

gaagccctgg tcaatggcca tgccaattca gcagtcccga acagtgtcag tgcagaggat      660

gcagaattta tgggtgacat gcccccgtca gttacgccca ggacttgtaa cagcccccag      720

aactccacag actctgtcag tgacattgtg cctgacagtc ctttccccgg agcactcggc      780

agtgacacca ggactgcagg gcagccagag gggggccccg gggctgattt tggtcagtcc      840

tgcttccctg cagaggctgg cagagacacc ctgtcaagga cagctggggc tcagccctgc      900

gttggtaccg atactactga aaaccttgga gttgctaatg gacaaatact tgaatcctcg      960

ggtgagggca cagctaccaa cggggtggag ttgcacacca cggaaagcat agacttggac     1020

ccaaccaaac ccgagagtgc atcacctcct gctgacggca cgggctctgc atcaggcacc     1080

cttcctgtca gccagcccaa gtcctgggcc agcctctttc atgattctaa gccctcttcc     1140

tcctcgccgg tggcctatgt ggaaactaag tattcccctc ccgccatatc tcccctggtt     1200

tctgaaaagc aggttgaagt caaagaaggg cttgttccgg tttcagagga tcctgtagcc     1260

ataaagattg cagtgttcgg ctaatgaatg agttcactaa tatgccagta cctccaaaac     1320

cccgacaagc tcttggagat aaaatcgtga gggatattcg ccctggagct gcctttgagc     1380

ccacatatat ttacagactc ctgacagtta acaagtcaag cctgtctgaa aagggtcgac     1440

aagaagatgc tgaggaatac ttaggcttca ttctaaatgg acttcatgag gaaatgttga     1500

acctaaagaa gcttctctca ccaagtaatg aaaaacttac gatttccaac ggccccaaaa     1560

accactcggt caatgaagaa gagcaggaag aacaaggtga aggaagcgag gatgaatggg     1620

aacaagtggg cccccggaac aagacttccg tcacccgcca ggcggatttt gttcagactc     1680

caatcaccgg catttttggt ggacacatca ggtctgtggt ttaccagcag agttcaaaag     1740

aatctgccac tttgcagcca tttttcacgt tgcagttgga tatccagtca gacaagatac     1800

gcacagtcca ggatgcactg gagagcttgg tggcaagaga atctgtccaa ggttatacca     1860

caaaaaccaa acaagaggtt gagataagtc gaagagtgac tctggaaaaa ctccctcctg     1920

tcctcgtgct gcacctgaaa cgattcgttt atgagaagac tggtgggtgc cagaagctta     1980

tcaaaaatat tgaatatcct gtggacttgg aaattagtaa agaactgctt tctccagggg     2040

ttaaaaataa gaattttaaa tgccaccgaa cctatcggct ctttgcagtg gtctaccatc     2100

acggcaacag tgcgacgggc ggccattaca ctacagacgt cttccagatc ggtctgaatg     2160

gctggctgcg catcgatgac cagacagtca aggtgatcaa ccagtaccag gtggtgaaac     2220

caactgctga acgcacagcc tacctcctgt attaccgccg agtggacctg ctgtaaaccc     2280

tgtgtgcgct gtgtgtgcgc ccagtgcccg cttcgtagga caccacctca cactcacttc     2340

ccgcctctct ttagtggctc tttagagaga aactctttct ccctttgcaa aaatgggcta     2400

gaatgaaaag gagatgcctt ggggttcgtg cacaacacag cttctgttga ctctaacttc     2460

caaatcaaaa tcatttggtt gaaacagact gttgcttgat tttagaaaat acacaaaaac     2520

ccatatttct gaaataatgc tgattcctga gataagaaag tggatttgat ccccagtctc     2580

attgcttagt agaataaatc ctgcaccagc aacaacactt gtaaatttgt gaaaatgaat     2640

tttatctttc cttaaaaaag aaatttttta atccatcaca cttttcttcc ctacccttta     2700

gtttttgata aatgataaaa atgagccagt tatcaaagaa gaactagttc ttacttcaaa     2760

agaaaaataa acataaaaaa taagttgctg gttcctaaca ggaaaaattt taataattgt     2820

actgagagaa actgcttacg tacacattgc agatcaaata tttggagtta aaatgttagt     2880

ctacatagat gggtgattgt aactttattg ccattaaaag atttcaaatt gcattcatgc     2940

ttctgtgtac acataatgaa aaatgggcaa ataatgaaga tctctccttc agtctgctct     3000

gtttaattct gctgtctgct cttctctaat gctgcgtccc taattgtaca cagtttagtg     3060

atatctagga gtataaagtt gtcgcccatc aataaaaatc acaaagttgg tttaaaaaaa     3120

aaaaaaaaaa aaaaaa                                                     3136


<210>  7
<211>  3848
<212>  DNA
<213>  Homo sapiens

<400>  7
acctgcagcg cgaggcgcgc cgctccaggc ggcatcgcag ggctgggccg gcgcggcctg       60

gggaccccgg gctccggagg ccatgccggc gttggcgcgc gacggcggcc agctgccgct      120

gctcgttgtt ttttctgcaa tgatatttgg gactattaca aatcaagatc tgcctgtgat      180

caagtgtgtt ttaatcaatc ataagaacaa tgattcatca gtggggaagt catcatcata      240

tcccatggta tcagaatccc cggaagacct cgggtgtgcg ttgagacccc agagctcagg      300

gacagtgtac gaagctgccg ctgtggaagt ggatgtatct gcttccatca cactgcaagt      360

gctggtcgac gccccaggga acatttcctg tctctgggtc tttaagcaca gctccctgaa      420

ttgccagcca cattttgatt tacaaaacag aggagttgtt tccatggtca ttttgaaaat      480

gacagaaacc caagctggag aatacctact ttttattcag agtgaagcta ccaattacac      540

aatattgttt acagtgagta taagaaatac cctgctttac acattaagaa gaccttactt      600

tagaaaaatg gaaaaccagg acgccctggt ctgcatatct gagagcgttc cagagccgat      660

cgtggaatgg gtgctttgcg attcacaggg ggaaagctgt aaagaagaaa gtccagctgt      720

tgttaaaaag gaggaaaaag tgcttcatga attatttggg acggacataa ggtgctgtgc      780

cagaaatgaa ctgggcaggg aatgcaccag gctgttcaca atagatctaa atcaaactcc      840

tcagaccaca ttgccacaat tatttcttaa agtaggggaa cccttatgga taaggtgcaa      900

agctgttcat gtgaaccatg gattcgggct cacctgggaa ttagaaaaca aagcactcga      960

ggagggcaac tactttgaga tgagtaccta ttcaacaaac agaactatga tacggattct     1020

gtttgctttt gtatcatcag tggcaagaaa cgacaccgga tactacactt gttcctcttc     1080

aaagcatccc agtcaatcag ctttggttac catcgtagaa aagggattta taaatgctac     1140

caattcaagt gaagattatg aaattgacca atatgaagag ttttgttttt ctgtcaggtt     1200

taaagcctac ccacaaatca gatgtacgtg gaccttctct cgaaaatcat ttccttgtga     1260

gcaaaagggt cttgataacg gatacagcat atccaagttt tgcaatcata agcaccagcc     1320

aggagaatat atattccatg cagaaaatga tgatgcccaa tttaccaaaa tgttcacgct     1380

gaatataaga aggaaacctc aagtgctcgc agaagcatcg gcaagtcagg cgtcctgttt     1440

ctcggatgga tacccattac catcttggac ctggaagaag tgttcagaca agtctcccaa     1500

ctgcacagaa gagatcacag aaggagtctg gaatagaaag gctaacagaa aagtgtttgg     1560

acagtgggtg tcgagcagta ctctaaacat gagtgaagcc ataaaagggt tcctggtcaa     1620

gtgctgtgca tacaattccc ttggcacatc ttgtgagacg atccttttaa actctccagg     1680

ccccttccct ttcatccaag acaacatctc attctatgca acaattggtg tttgtctcct     1740

cttcattgtc gttttaaccc tgctaatttg tcacaagtac aaaaagcaat ttaggtatga     1800

aagccagcta cagatggtac aggtgaccgg ctcctcagat aatgagtact tctacgttga     1860

tttcagagaa tatgaatatg atctcaaatg ggagtttcca agagaaaatt tagagtttgg     1920

gaaggtacta ggatcaggtg cttttggaaa agtgatgaac gcaacagctt atggaattag     1980

caaaacagga gtctcaatcc aggttgccgt caaaatgctg aaagaaaaag cagacagctc     2040

tgaaagagag gcactcatgt cagaactcaa gatgatgacc cagctgggaa gccacgagaa     2100

tattgtgaac ctgctggggg cgtgcacact gtcaggacca atttacttga tttttgaata     2160

ctgttgctat ggtgatcttc tcaactatct aagaagtaaa agagaaaaat ttcacaggac     2220

ttggacagag attttcaagg aacacaattt cagtttttac cccactttcc aatcacatcc     2280

aaattccagc atgcctggtt caagagaagt tcagatacac ccggactcgg atcaaatctc     2340

agggcttcat gggaattcat ttcactctga agatgaaatt gaatatgaaa accaaaaaag     2400

gctggaagaa gaggaggact tgaatgtgct tacatttgaa gatcttcttt gctttgcata     2460

tcaagttgcc aaaggaatgg aatttctgga atttaagtcg tgtgttcaca gagacctggc     2520

cgccaggaac gtgcttgtca cccacgggaa agtggtgaag atatgtgact ttggattggc     2580

tcgagatatc atgagtgatt ccaactatgt tgtcaggggc aatgcccgtc tgcctgtaaa     2640

atggatggcc cccgaaagcc tgtttgaagg catctacacc attaagagtg atgtctggtc     2700

atatggaata ttactgtggg aaatcttctc acttggtgtg aatccttacc ctggcattcc     2760

ggttgatgct aacttctaca aactgattca aaatggattt aaaatggatc agccatttta     2820

tgctacagaa gaaatataca ttataatgca atcctgctgg gcttttgact caaggaaacg     2880

gccatccttc cctaatttga cttcgttttt aggatgtcag ctggcagatg cagaagaagc     2940

gatgtatcag aatgtggatg gccgtgtttc ggaatgtcct cacacctacc aaaacaggcg     3000

acctttcagc agagagatgg atttggggct actctctccg caggctcagg tcgaagattc     3060

gtagaggaac aatttagttt taaggacttc atccctccac ctatccctaa caggctgtag     3120

attaccaaaa caagattaat ttcatcacta aaagaaaatc tattatcaac tgctgcttca     3180

ccagactttt ctctagaagc tgtctgcgtt tactcttgtt ttcaaaggga cttttgtaaa     3240

atcaaatcat cctgtcacaa ggcaggagga gctgataatg aactttattg gagcattgat     3300

ctgcatccaa ggccttctca ggctggcttg agtgaattgt gtacctgaag tacagtatat     3360

tcttgtaaat acataaaaca aaagcatttt gctaaggaga agctaatatg attttttaag     3420

tctatgtttt aaaataatat gtaaattttt cagctattta gtgatatatt ttatgggtgg     3480

gaataaaatt tctactacag aattgcccat tattgaatta tttacatggt ataattaggg     3540

caagtcttaa ctggagttca cgaaccccct gaaattgtgc acccatagcc acctacacat     3600

tccttccaga gcacgtgtgc ttttacccca agatacaagg aatgtgtagg cagctatggt     3660

tgtcacagcc taagatttct gcaacaacag gggttgtatt gggggaagtt tataatgaat     3720

aggtgttcta ccataaagag taatacatca cctagacact ttggcggcct tcccagactc     3780

agggccagtc agaagtaaca tggaggatta gtattttcaa taaagttact cttgtcccca     3840

caaaaaaa                                                              3848


<210>  8
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  9
<211>  3980
<212>  DNA
<213>  Homo sapiens

<400>  9
acctgcagcg cgaggcgcgc cgctccaggc ggcatcgcag ggctgggccg gcgcggcctg       60

gggaccccgg gctccggagg ccatgccggc gttggcgcgc gacggcggcc agctgccgct      120

gctcgttgtt ttttctgcaa tgatatttgg gactattaca aatcaagatc tgcctgtgat      180

caagtgtgtt ttaatcaatc ataagaacaa tgattcatca gtggggaagt catcatcata      240

tcccatggta tcagaatccc cggaagacct cgggtgtgcg ttgagacccc agagctcagg      300

gacagtgtac gaagctgccg ctgtggaagt ggatgtatct gcttccatca cactgcaagt      360

gctggtcgac gccccaggga acatttcctg tctctgggtc tttaagcaca gctccctgaa      420

ttgccagcca cattttgatt tacaaaacag aggagttgtt tccatggtca ttttgaaaat      480

gacagaaacc caagctggag aatacctact ttttattcag agtgaagcta ccaattacac      540

aatattgttt acagtgagta taagaaatac cctgctttac acattaagaa gaccttactt      600

tagaaaaatg gaaaaccagg acgccctggt ctgcatatct gagagcgttc cagagccgat      660

cgtggaatgg gtgctttgcg attcacaggg ggaaagctgt aaagaagaaa gtccagctgt      720

tgttaaaaag gaggaaaaag tgcttcatga attatttggg acggacataa ggtgctgtgc      780

cagaaatgaa ctgggcaggg aatgcaccag gctgttcaca atagatctaa atcaaactcc      840

tcagaccaca ttgccacaat tatttcttaa agtaggggaa cccttatgga taaggtgcaa      900

agctgttcat gtgaaccatg gattcgggct cacctgggaa ttagaaaaca aagcactcga      960

ggagggcaac tactttgaga tgagtaccta ttcaacaaac agaactatga tacggattct     1020

gtttgctttt gtatcatcag tggcaagaaa cgacaccgga tactacactt gttcctcttc     1080

aaagcatccc agtcaatcag ctttggttac catcgtagaa aagggattta taaatgctac     1140

caattcaagt gaagattatg aaattgacca atatgaagag ttttgttttt ctgtcaggtt     1200

taaagcctac ccacaaatca gatgtacgtg gaccttctct cgaaaatcat ttccttgtga     1260

gcaaaagggt cttgataacg gatacagcat atccaagttt tgcaatcata agcaccagcc     1320

aggagaatat atattccatg cagaaaatga tgatgcccaa tttaccaaaa tgttcacgct     1380

gaatataaga aggaaacctc aagtgctcgc agaagcatcg gcaagtcagg cgtcctgttt     1440

ctcggatgga tacccattac catcttggac ctggaagaag tgttcagaca agtctcccaa     1500

ctgcacagaa gagatcacag aaggagtctg gaatagaaag gctaacagaa aagtgtttgg     1560

acagtgggtg tcgagcagta ctctaaacat gagtgaagcc ataaaagggt tcctggtcaa     1620

gtgctgtgca tacaattccc ttggcacatc ttgtgagacg atccttttaa actctccagg     1680

ccccttccct ttcatccaag acaacatctc attctatgca acaattggtg tttgtctcct     1740

cttcattgtc gttttaaccc tgctaatttg tcacaagtac aaaaagcaat ttaggtatga     1800

aagccagcta cagatggtac aggtgaccgg ctcctcagat aatgagtact tctacgttga     1860

tttcagagaa tatgaatatg atctcaaatg ggagtttcca agagaaaatt tagagtttgg     1920

gaaggtacta ggatcaggtg cttttggaaa agtgatgaac gcaacagctt atggaattag     1980

caaaacagga gtctcaatcc aggttgccgt caaaatgctg aaagaaaaag cagacagctc     2040

tgaaagagag gcactcatgt cagaactcaa gatgatgacc cagctgggaa gccacgagaa     2100

tattgtgaac ctgctggggg cgtgcacact gtcaggacca atttacttga tttttgaata     2160

ctgttgctat ggtgatcttc tcaactatct aagaagtaaa agagaaaaat ttcacaggac     2220

ttggacagag attttcaagg aacacaattt cagtttttac cccactttcc aatcacatcc     2280

aaattccagt aaaaagaaat gagctttaca aaggcaaact ggaaaaaaga aggatggtga     2340

aacgcttacg ggactctcgg gaagatctgt attatgtgag ggaaagtggg ctgagttcag     2400

aaaccaaaga atgagatcga tcatgcctgg ttcaagagaa gttcagatac acccggactc     2460

ggatcaaatc tcagggcttc atgggaattc atttcactct gaagatgaaa ttgaatatga     2520

aaaccaaaaa aggctggaag aagaggagga cttgaatgtg cttacatttg aagatcttct     2580

ttgctttgca tatcaagttg ccaaaggaat ggaatttctg gaatttaagt cgtgtgttca     2640

cagagacctg gccgccagga acgtgcttgt cacccacggg aaagtggtga agatatgtga     2700

ctttggattg gctcgagata tcatgagtga ttccaactat gttgtcaggg gcaatgcccg     2760

tctgcctgta aaatggatgg cccccgaaag cctgtttgaa ggcatctaca ccattaagag     2820

tgatgtctgg tcatatggaa tattactgtg ggaaatcttc tcacttggtg tgaatcctta     2880

ccctggcatt ccggttgatg ctaacttcta caaactgatt caaaatggat ttaaaatgga     2940

tcagccattt tatgctacag aagaaatata cattataatg caatcctgct gggcttttga     3000

ctcaaggaaa cggccatcct tccctaattt gacttcgttt ttaggatgtc agctggcaga     3060

tgcagaagaa gcgatgtatc agaatgtgga tggccgtgtt tcggaatgtc ctcacaccta     3120

ccaaaacagg cgacctttca gcagagagat ggatttgggg ctactctctc cgcaggctca     3180

ggtcgaagat tcgtagagga acaatttagt tttaaggact tcatccctcc acctatccct     3240

aacaggctgt agattaccaa aacaagatta atttcatcac taaaagaaaa tctattatca     3300

actgctgctt caccagactt ttctctagaa gctgtctgcg tttactcttg ttttcaaagg     3360

gacttttgta aaatcaaatc atcctgtcac aaggcaggag gagctgataa tgaactttat     3420

tggagcattg atctgcatcc aaggccttct caggctggct tgagtgaatt gtgtacctga     3480

agtacagtat attcttgtaa atacataaaa caaaagcatt ttgctaagga gaagctaata     3540

tgatttttta agtctatgtt ttaaaataat atgtaaattt ttcagctatt tagtgatata     3600

ttttatgggt gggaataaaa tttctactac agaattgccc attattgaat tatttacatg     3660

gtataattag ggcaagtctt aactggagtt cacgaacccc ctgaaattgt gcacccatag     3720

ccacctacac attccttcca gagcacgtgt gcttttaccc caagatacaa ggaatgtgta     3780

ggcagctatg gttgtcacag cctaagattt ctgcaacaac aggggttgta ttgggggaag     3840

tttataatga ataggtgttc taccataaag agtaatacat cacctagaca ctttggcggc     3900

cttcccagac tcagggccag tcagaagtaa catggaggat tagtattttc aataaagtta     3960

ctcttgtccc cacaaaaaaa                                                 3980