                         SEQUENCE LISTING

<110>  MedImmune LLC
 
<120>  COMPOSITIONS AND METHODS FOR CHARACTERIZING SOLID TUMORS 
       RESPONSIVENESS TO ANTI-PD-L1 ANTIBODY MONOTHERAPY

<130>  B7H1-465-WO-PCT

<140>  PCT/US2017/052246
<141>  2017-09-19

<150>  US 62/397062
<151>  2016-09-20

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  2
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Phe Thr Phe Ser Arg Tyr Trp Met Ser 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Tyr Gly Ser Leu Pro Trp Thr 
1               5                   


<210>  9
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  10
<211>  1237
<212>  DNA
<213>  Homo sapiens

<400>  10
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

tcacaacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                              1237


<210>  11
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
65                  70                  75                  80  


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
                165                 170                 175     


<210>  12
<211>  3349
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg ccccatacaa caaaatcaac      180

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      240

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      300

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      360

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      420

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      480

actcacttgg taattctggg agccatctta ttatgccttg gtgtagcact gacattcatc      540

ttccgtttaa gaaaagggag aatgatggat gtgaaaaaat gtggcatcca agatacaaac      600

tcaaagaagc aaagtgatac acatttggag gagacgtaat ccagcattgg aacttctgat      660

cttcaagcag ggattctcaa cctgtggttt aggggttcat cggggctgag cgtgacaaga      720

ggaaggaatg ggcccgtggg atgcaggcaa tgtgggactt aaaaggccca agcactgaaa      780

atggaacctg gcgaaagcag aggaggagaa tgaagaaaga tggagtcaaa cagggagcct      840

ggagggagac cttgatactt tcaaatgcct gaggggctca tcgacgcctg tgacagggag      900

aaaggatact tctgaacaag gagcctccaa gcaaatcatc cattgctcat cctaggaaga      960

cgggttgaga atccctaatt tgagggtcag ttcctgcaga agtgcccttt gcctccactc     1020

aatgcctcaa tttgttttct gcatgactga gagtctcagt gttggaacgg gacagtattt     1080

atgtatgagt ttttcctatt tattttgagt ctgtgaggtc ttcttgtcat gtgagtgtgg     1140

ttgtgaatga tttcttttga agatatattg tagtagatgt tacaattttg tcgccaaact     1200

aaacttgctg cttaatgatt tgctcacatc tagtaaaaca tggagtattt gtaaggtgct     1260

tggtctcctc tataactaca agtatacatt ggaagcataa agatcaaacc gttggttgca     1320

taggatgtca cctttattta acccattaat actctggttg acctaatctt attctcagac     1380

ctcaagtgtc tgtgcagtat ctgttccatt taaatatcag ctttacaatt atgtggtagc     1440

ctacacacat aatctcattt catcgctgta accaccctgt tgtgataacc actattattt     1500

tacccatcgt acagctgagg aagcaaacag attaagtaac ttgcccaaac cagtaaatag     1560

cagacctcag actgccaccc actgtccttt tataatacaa tttacagcta tattttactt     1620

taagcaattc ttttattcaa aaaccattta ttaagtgccc ttgcaatatc aatcgctgtg     1680

ccaggcattg aatctacaga tgtgagcaag acaaagtacc tgtcctcaag gagctcatag     1740

tataatgagg agattaacaa gaaaatgtat tattacaatt tagtccagtg tcatagcata     1800

aggatgatgc gaggggaaaa cccgagcagt gttgccaaga ggaggaaata ggccaatgtg     1860

gtctgggacg gttggatata cttaaacatc ttaataatca gagtaatttt catttacaaa     1920

gagaggtcgg tacttaaaat aaccctgaaa aataacactg gaattccttt tctagcatta     1980

tatttattcc tgatttgcct ttgccatata atctaatgct tgtttatata gtgtctggta     2040

ttgtttaaca gttctgtctt ttctatttaa atgccactaa attttaaatt catacctttc     2100

catgattcaa aattcaaaag atcccatggg agatggttgg aaaatctcca cttcatcctc     2160

caagccattc aagtttcctt tccagaagca actgctactg cctttcattc atatgttctt     2220

ctaaagatag tctacatttg gaaatgtatg ttaaaagcac gtatttttaa aatttttttc     2280

ctaaatagta acacattgta tgtctgctgt gtactttgct atttttattt attttagtgt     2340

ttcttatata gcagatggaa tgaatttgaa gttcccaggg ctgaggatcc atgccttctt     2400

tgtttctaag ttatctttcc catagctttt cattatcttt catatgatcc agtatatgtt     2460

aaatatgtcc tacatataca tttagacaac caccatttgt taagtatttg ctctaggaca     2520

gagtttggat ttgtttatgt ttgctcaaaa ggagacccat gggctctcca gggtgcactg     2580

agtcaatcta gtcctaaaaa gcaatcttat tattaactct gtatgacaga atcatgtctg     2640

gaacttttgt tttctgcttt ctgtcaagta taaacttcac tttgatgctg tacttgcaaa     2700

atcacatttt ctttctggaa attccggcag tgtaccttga ctgctagcta ccctgtgcca     2760

gaaaagcctc attcgttgtg cttgaaccct tgaatgccac cagctgtcat cactacacag     2820

ccctcctaag aggcttcctg gaggtttcga gattcagatg ccctgggaga tcccagagtt     2880

tcctttccct cttggccata ttctggtgtc aatgacaagg agtaccttgg ctttgccaca     2940

tgtcaaggct gaagaaacag tgtctccaac agagctcctt gtgttatctg tttgtacatg     3000

tgcatttgta cagtaattgg tgtgacagtg ttctttgtgt gaattacagg caagaattgt     3060

ggctgagcaa ggcacatagt ctactcagtc tattcctaag tcctaactcc tccttgtggt     3120

gttggatttg taaggcactt tatccctttt gtctcatgtt tcatcgtaaa tggcataggc     3180

agagatgata cctaattctg catttgattg tcactttttg tacctgcatt aatttaataa     3240

aatattctta tttattttgt tacttggtac accagcatgt ccattttctt gtttattttg     3300

tgtttaataa aatgttcagt ttaacatccc agtggagaaa gttaaaaaa                 3349


<210>  13
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  14
<211>  2723
<212>  DNA
<213>  Homo sapiens

<400>  14
aaaatgtgtt ctctaaagaa tttctcaggc tcaaaatcca atacaggagt gacttggaac       60

tccattctat cactatgaag aaaagtggtg ttcttttcct cttgggcatc atcttgctgg      120

ttctgattgg agtgcaagga accccagtag tgagaaaggg tcgctgttcc tgcatcagca      180

ccaaccaagg gactatccac ctacaatcct tgaaagacct taaacaattt gccccaagcc      240

cttcctgcga gaaaattgaa atcattgcta cactgaagaa tggagttcaa acatgtctaa      300

acccagattc agcagatgtg aaggaactga ttaaaaagtg ggagaaacag gtcagccaaa      360

agaaaaagca aaagaatggg aaaaaacatc aaaaaaagaa agttctgaaa gttcgaaaat      420

ctcaacgttc tcgtcaaaag aagactacat aagagaccac ttcaccaata agtattctgt      480

gttaaaaatg ttctatttta attataccgc tatcattcca aaggaggatg gcatataata      540

caaaggctta ttaatttgac tagaaaattt aaaacattac tctgaaattg taactaaagt      600

tagaaagttg attttaagaa tccaaacgtt aagaattgtt aaaggctatg attgtctttg      660

ttcttctacc acccaccagt tgaatttcat catgcttaag gccatgattt tagcaatacc      720

catgtctaca cagatgttca cccaaccaca tcccactcac aacagctgcc tggaagagca      780

gccctaggct tccacgtact gcagcctcca gagagtatct gaggcacatg tcagcaagtc      840

ctaagcctgt tagcatgctg gtgagccaag cagtttgaaa ttgagctgga cctcaccaag      900

ctgctgtggc catcaacctc tgtatttgaa tcagcctaca ggcctcacac acaatgtgtc      960

tgagagattc atgctgattg ttattgggta tcaccactgg agatcaccag tgtgtggctt     1020

tcagagcctc ctttctggct ttggaagcca tgtgattcca tcttgcccgc tcaggctgac     1080

cactttattt ctttttgttc ccctttgctt cattcaagtc agctcttctc catcctacca     1140

caatgcagtg cctttcttct ctccagtgca cctgtcatat gctctgattt atctgagtca     1200

actcctttct catcttgtcc ccaacacccc acagaagtgc tttcttctcc caattcatcc     1260

tcactcagtc cagcttagtt caagtcctgc ctcttaaata aacctttttg gacacacaaa     1320

ttatcttaaa actcctgttt cacttggttc agtaccacat gggtgaacac tcaatggtta     1380

actaattctt gggtgtttat cctatctctc caaccagatt gtcagctcct tgagggcaag     1440

agccacagta tatttccctg tttcttccac agtgcctaat aatactgtgg aactaggttt     1500

taataatttt ttaattgatg ttgttatggg caggatggca accagaccat tgtctcagag     1560

caggtgctgg ctctttcctg gctactccat gttggctagc ctctggtaac ctcttactta     1620

ttatcttcag gacactcact acagggacca gggatgatgc aacatccttg tctttttatg     1680

acaggatgtt tgctcagctt ctccaacaat aagaagcacg tggtaaaaca cttgcggata     1740

ttctggactg tttttaaaaa atatacagtt taccgaaaat catataatct tacaatgaaa     1800

aggactttat agatcagcca gtgaccaacc ttttcccaac catacaaaaa ttccttttcc     1860

cgaaggaaaa gggctttctc aataagcctc agctttctaa gatctaacaa gatagccacc     1920

gagatcctta tcgaaactca ttttaggcaa atatgagttt tattgtccgt ttacttgttt     1980

cagagtttgt attgtgatta tcaattacca caccatctcc catgaagaaa gggaacggtg     2040

aagtactaag cgctagagga agcagccaag tcggttagtg gaagcatgat tggtgcccag     2100

ttagcctctg caggatgtgg aaacctcctt ccaggggagg ttcagtgaat tgtgtaggag     2160

aggttgtctg tggccagaat ttaaacctat actcactttc ccaaattgaa tcactgctca     2220

cactgctgat gatttagagt gctgtccggt ggagatccca cccgaacgtc ttatctaatc     2280

atgaaactcc ctagttcctt catgtaactt ccctgaaaaa tctaagtgtt tcataaattt     2340

gagagtctgt gacccactta ccttgcatct cacaggtaga cagtatataa ctaacaacca     2400

aagactacat attgtcactg acacacacgt tataatcatt tatcatatat atacatacat     2460

gcatacactc tcaaagcaaa taatttttca cttcaaaaca gtattgactt gtataccttg     2520

taatttgaaa tattttcttt gttaaaatag aatggtatca ataaatagac cattaatcag     2580

aaaacagatc ttgatttttt ttctcttgaa tgtacccttc aactgttgaa tgtttaatag     2640

taaatcttat atgtccttat ttacttttta gctttctctc aaataaagtg taacactagt     2700

tgagataaaa aaaaaaaaaa aaa                                             2723


<210>  15
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  16
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  16
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc      180

aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta      240

gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt      300

attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg      360

gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg      420

aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag      480

cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg      540

gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa      600

gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc      660

aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat      720

gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg      780

gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg      840

ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg      900

agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat      960

acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc     1020

aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg     1080

ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc     1140

agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac     1200

tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca     1260

aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa     1320

tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt     1380

ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta     1440

tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt     1500

gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga     1560

tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta     1620

caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt     1680

taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt     1740

atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat     1800

ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga     1860

ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac     1920

ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc     1980

aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca     2040

gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac     2100

aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa     2160

aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata     2220

tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa     2280

ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc     2340

ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc     2400

ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa     2460

agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc     2520

tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt     2580

tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg     2640

tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg     2700

aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt     2760

cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata     2820

catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat     2880

gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa     2940

aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct     3000

ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg     3060

aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg     3120

tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc     3180

tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca     3240

tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac     3300

agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt     3360

ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata     3420

gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac     3480

tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc     3540

tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt     3600

gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca     3660

gtttaacatc ccagtggaga aagttaaaaa a                                    3691


<210>  17
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Gly Gln Pro Gln Val Gly Lys Glu 
        355                 360 


<210>  18
<211>  1995
<212>  DNA
<213>  Homo sapiens

<400>  18
acaggggtga aggcccagag accagcagaa cggcatccca gccacgacgg ccactttgct       60

ctgtctgctc tccgccacgg ccctgctctg ttccctggga cacccccgcc cccacctcct      120

caggctgcct gatctgccca gctttccagc tttcctctgg attccggcct ctggtcatcc      180

ctccccaccc tctctccaag gccctctcct ggtctccctt cttctagaac cccttcctcc      240

acctccctct ctgcagaact tctcctttac cccccacccc ccaccactgc cccctttcct      300

tttctgacct ccttttggag ggctcagcgc tgcccagacc ataggagaga tgtgggaggc      360

tcagttcctg ggcttgctgt ttctgcagcc gctttgggtg gctccagtga agcctctcca      420

gccaggggct gaggtcccgg tggtgtgggc ccaggagggg gctcctgccc agctcccctg      480

cagccccaca atccccctcc aggatctcag ccttctgcga agagcagggg tcacttggca      540

gcatcagcca gacagtggcc cgcccgctgc cgcccccggc catcccctgg cccccggccc      600

tcacccggcg gcgccctcct cctgggggcc caggccccgc cgctacacgg tgctgagcgt      660

gggtcccgga ggcctgcgca gcgggaggct gcccctgcag ccccgcgtcc agctggatga      720

gcgcggccgg cagcgcgggg acttctcgct atggctgcgc ccagcccggc gcgcggacgc      780

cggcgagtac cgcgccgcgg tgcacctcag ggaccgcgcc ctctcctgcc gcctccgtct      840

gcgcctgggc caggcctcga tgactgccag ccccccagga tctctcagag cctccgactg      900

ggtcattttg aactgctcct tcagccgccc tgaccgccca gcctctgtgc attggttccg      960

gaaccggggc cagggccgag tccctgtccg ggagtccccc catcaccact tagcggaaag     1020

cttcctcttc ctgccccaag tcagccccat ggactctggg ccctggggct gcatcctcac     1080

ctacagagat ggcttcaacg tctccatcat gtataacctc actgttctgg gtctggagcc     1140

cccaactccc ttgacagtgt acgctggagc aggttccagg gtggggctgc cctgccgcct     1200

gcctgctggt gtggggaccc ggtctttcct cactgccaag tggactcctc ctgggggagg     1260

ccctgacctc ctggtgactg gagacaatgg cgactttacc cttcgactag aggatgtgag     1320

ccaggcccag gctgggacct acacctgcca tatccatctg caggaacagc agctcaatgc     1380

cactgtcaca ttggcaatca tcacagtgac tcccaaatcc tttgggtcac ctggatccct     1440

ggggaagctg ctttgtgagg tgactccagt atctggacaa gaacgctttg tgtggagctc     1500

tctggacacc ccatcccaga ggagtttctc aggaccttgg ctggaggcac aggaggccca     1560

gctcctttcc cagccttggc aatgccagct gtaccagggg gagaggcttc ttggagcagc     1620

agtgtacttc acagagctgt ctagcccagg tgcccaacgc tctgggagag ccccaggtgc     1680

cctcccagca ggccacctcc tgctgtttct catccttggt gtcctttctc tgctcctttt     1740

ggtgactgga gcctttggct ttcacctttg gagaagacag tggcgaccaa gacgattttc     1800

tgccttagag caagggattc accctccgca ggctcagagc aagatagagg agctggagca     1860

agaaccggag ccggagccgg agccggaacc ggagcccgag cccgagcccg agccggagca     1920

gctctgacct ggagctgagg cagccagcag atctcagcag cccagtccaa ataaactccc     1980

tgtcagcagc aaaaa                                                      1995


