                         SEQUENCE LISTING

<110>  Nanyang Technological University
 
<120>  CO-CRYSTALS OF NURR1-LBD IN COMPLEX WITH A CYCLOPENTENONE 
       PROSTAGLANDIN AND MODULATORS OF NURR1

<130>  P112800

<150>  Singapore Patent Application No. 10201607854Q
<151>  2016-09-20

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly 
1               5                   10                  15      


Arg Leu Pro Ser Lys Pro Lys Ser Pro Gln Glu Pro Ser Pro Pro Ser 
            20                  25                  30          


Pro Pro Val Ser Leu Ile Ser Ala Leu Val Arg Ala His Val Asp Ser 
        35                  40                  45              


Asn Pro Ala Met Thr Ser Leu Asp Tyr Ser Arg Phe Gln Ala Asn Pro 
    50                  55                  60                  


Asp Tyr Gln Met Ser Gly Asp Asp Thr Gln His Ile Gln Gln Phe Tyr 
65                  70                  75                  80  


Asp Leu Leu Thr Gly Ser Met Glu Ile Ile Arg Gly Trp Ala Glu Lys 
                85                  90                  95      


Ile Pro Gly Phe Ala Asp Leu Pro Lys Ala Asp Gln Asp Leu Leu Phe 
            100                 105                 110         


Glu Ser Ala Phe Leu Glu Leu Phe Val Leu Arg Leu Ala Tyr Arg Ser 
        115                 120                 125             


Asn Pro Val Glu Gly Lys Leu Ile Phe Cys Asn Gly Val Val Leu His 
    130                 135                 140                 


Arg Leu Gln Cys Val Arg Gly Phe Gly Glu Trp Ile Asp Ser Ile Val 
145                 150                 155                 160 


Glu Phe Ser Ser Asn Leu Gln Asn Met Asn Ile Asp Ile Ser Ala Phe 
                165                 170                 175     


Ser Cys Ile Ala Ala Leu Ala Met Val Thr Glu Arg His Gly Leu Lys 
            180                 185                 190         


Glu Pro Lys Arg Val Glu Glu Leu Gln Asn Lys Ile Val Asn Cys Leu 
        195                 200                 205             


Lys Asp His Val Thr Phe Asn Asn Gly Gly Leu Asn Arg Pro Asn Tyr 
    210                 215                 220                 


Leu Ser Lys Leu Leu Gly Lys Leu Pro Glu Leu Arg Thr Leu Cys Thr 
225                 230                 235                 240 


Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp Leu Val Pro 
                245                 250                 255     


Pro Pro Ala Ile Ile Asp Lys Leu Phe Leu Asp Thr Leu Pro Phe 
            260                 265                 270     


<210>  2
<211>  271
<212>  PRT
<213>  Mus musculus

<400>  2

Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly 
1               5                   10                  15      


Arg Leu Pro Ser Lys Pro Lys Ser Pro Gln Asp Pro Ser Pro Pro Ser 
            20                  25                  30          


Pro Pro Val Ser Leu Ile Ser Ala Leu Val Arg Ala His Val Asp Ser 
        35                  40                  45              


Asn Pro Ala Met Thr Ser Leu Asp Tyr Ser Arg Phe Gln Ala Asn Pro 
    50                  55                  60                  


Asp Tyr Gln Met Ser Gly Asp Asp Thr Gln His Ile Gln Gln Phe Tyr 
65                  70                  75                  80  


Asp Leu Leu Thr Gly Ser Met Glu Ile Ile Arg Gly Trp Ala Glu Lys 
                85                  90                  95      


Ile Pro Gly Phe Ala Asp Leu Pro Lys Ala Asp Gln Asp Leu Leu Phe 
            100                 105                 110         


Glu Ser Ala Phe Leu Glu Leu Phe Val Leu Arg Leu Ala Tyr Arg Ser 
        115                 120                 125             


Asn Pro Val Glu Gly Lys Leu Ile Phe Cys Asn Gly Val Val Leu His 
    130                 135                 140                 


Arg Leu Gln Cys Val Arg Gly Phe Gly Glu Trp Ile Asp Ser Ile Val 
145                 150                 155                 160 


Glu Phe Ser Ser Asn Leu Gln Asn Met Asn Ile Asp Ile Ser Ala Phe 
                165                 170                 175     


Ser Cys Ile Ala Ala Leu Ala Met Val Thr Glu Arg His Gly Leu Lys 
            180                 185                 190         


Glu Pro Lys Arg Val Glu Glu Leu Gln Asn Lys Ile Val Asn Cys Leu 
        195                 200                 205             


Lys Asp His Val Thr Phe Asn Asn Gly Gly Leu Asn Arg Pro Asn Tyr 
    210                 215                 220                 


Leu Ser Lys Leu Leu Gly Lys Leu Pro Glu Leu Arg Thr Leu Cys Thr 
225                 230                 235                 240 


Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp Leu Val Pro 
                245                 250                 255     


Pro Pro Ala Ile Ile Asp Lys Leu Phe Leu Asp Thr Leu Pro Phe 
            260                 265                 270     


<210>  3
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  4
<211>  598
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Ser Thr Pro Ser Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  5
<211>  598
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Ser Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


