                         SEQUENCE LISTING

<110>  University Court of the University of St Andrews
       Connaris, Helen
       Taylor, Garry
       Andrew, Peter
       Yesilkaya, Hasan
 
<120>  Treatment and/or prevention of Sepsis

<130>  PG446840WO

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  781
<212>  PRT
<213>  Vibrio cholerae

<400>  1

Met Arg Phe Lys Asn Val Lys Lys Thr Ala Leu Met Leu Ala Met Phe 
1               5                   10                  15      


Gly Met Ala Thr Ser Ser Asn Ala Ala Leu Phe Asp Tyr Asn Ala Thr 
            20                  25                  30          


Gly Asp Thr Glu Phe Asp Ser Pro Ala Lys Gln Gly Trp Met Gln Asp 
        35                  40                  45              


Asn Thr Asn Asn Gly Ser Gly Val Leu Thr Asn Ala Asp Gly Met Pro 
    50                  55                  60                  


Ala Trp Leu Val Gln Gly Ile Gly Gly Arg Ala Gln Trp Thr Tyr Ser 
65                  70                  75                  80  


Leu Ser Thr Asn Gln His Ala Gln Ala Ser Ser Phe Gly Trp Arg Met 
                85                  90                  95      


Thr Thr Glu Met Lys Val Leu Ser Gly Gly Met Ile Thr Asn Tyr Tyr 
            100                 105                 110         


Ala Asn Gly Thr Gln Arg Val Leu Pro Ile Ile Ser Leu Asp Ser Ser 
        115                 120                 125             


Gly Asn Leu Val Val Glu Phe Glu Gly Gln Thr Gly Arg Thr Val Leu 
    130                 135                 140                 


Ala Thr Gly Thr Ala Ala Thr Glu Tyr His Lys Phe Glu Leu Val Phe 
145                 150                 155                 160 


Leu Pro Gly Ser Asn Pro Ser Ala Ser Phe Tyr Phe Asp Gly Lys Leu 
                165                 170                 175     


Ile Arg Asp Asn Ile Gln Pro Thr Ala Ser Lys Gln Asn Met Ile Val 
            180                 185                 190         


Trp Gly Asn Gly Ser Ser Asn Thr Asp Gly Val Ala Ala Tyr Arg Asp 
        195                 200                 205             


Ile Lys Phe Glu Ile Gln Gly Asp Val Ile Phe Arg Gly Pro Asp Arg 
    210                 215                 220                 


Ile Pro Ser Ile Val Ala Ser Ser Val Thr Pro Gly Val Val Thr Ala 
225                 230                 235                 240 


Phe Ala Glu Lys Arg Val Gly Gly Gly Asp Pro Gly Ala Leu Ser Asn 
                245                 250                 255     


Thr Asn Asp Ile Ile Thr Arg Thr Ser Arg Asp Gly Gly Ile Thr Trp 
            260                 265                 270         


Asp Thr Glu Leu Asn Leu Thr Glu Gln Ile Asn Val Ser Asp Glu Phe 
        275                 280                 285             


Asp Phe Ser Asp Pro Arg Pro Ile Tyr Asp Pro Ser Ser Asn Thr Val 
    290                 295                 300                 


Leu Val Ser Tyr Ala Arg Trp Pro Thr Asp Ala Ala Gln Asn Gly Asp 
305                 310                 315                 320 


Arg Ile Lys Pro Trp Met Pro Asn Gly Ile Phe Tyr Ser Val Tyr Asp 
                325                 330                 335     


Val Ala Ser Gly Asn Trp Gln Ala Pro Ile Asp Val Thr Asp Gln Val 
            340                 345                 350         


Lys Glu Arg Ser Phe Gln Ile Ala Gly Trp Gly Gly Ser Glu Leu Tyr 
        355                 360                 365             


Arg Arg Asn Thr Ser Leu Asn Ser Gln Gln Asp Trp Gln Ser Asn Ala 
    370                 375                 380                 


Lys Ile Arg Ile Val Asp Gly Ala Ala Asn Gln Ile Gln Val Ala Asp 
385                 390                 395                 400 


Gly Ser Arg Lys Tyr Val Val Thr Leu Ser Ile Asp Glu Ser Gly Gly 
                405                 410                 415     


Leu Val Ala Asn Leu Asn Gly Val Ser Ala Pro Ile Ile Leu Gln Ser 
            420                 425                 430         


Glu His Ala Lys Val His Ser Phe His Asp Tyr Glu Leu Gln Tyr Ser 
        435                 440                 445             


Ala Leu Asn His Thr Thr Thr Leu Phe Val Asp Gly Gln Gln Ile Thr 
    450                 455                 460                 


Thr Trp Ala Gly Glu Val Ser Gln Glu Asn Asn Ile Gln Phe Gly Asn 
465                 470                 475                 480 


Ala Asp Ala Gln Ile Asp Gly Arg Leu His Val Gln Lys Ile Val Leu 
                485                 490                 495     


Thr Gln Gln Gly His Asn Leu Val Glu Phe Asp Ala Phe Tyr Leu Ala 
            500                 505                 510         


Gln Gln Thr Pro Glu Val Glu Lys Asp Leu Glu Lys Leu Gly Trp Thr 
        515                 520                 525             


Lys Ile Lys Thr Gly Asn Thr Met Ser Leu Tyr Gly Asn Ala Ser Val 
    530                 535                 540                 


Asn Pro Gly Pro Gly His Gly Ile Thr Leu Thr Arg Gln Gln Asn Ile 
545                 550                 555                 560 


Ser Gly Ser Gln Asn Gly Arg Leu Ile Tyr Pro Ala Ile Val Leu Asp 
                565                 570                 575     


Arg Phe Phe Leu Asn Val Met Ser Ile Tyr Ser Asp Asp Gly Gly Ser 
            580                 585                 590         


Asn Trp Gln Thr Gly Ser Thr Leu Pro Ile Pro Phe Arg Trp Lys Ser 
        595                 600                 605             


Ser Ser Ile Leu Glu Thr Leu Glu Pro Ser Glu Ala Asp Met Val Glu 
    610                 615                 620                 


Leu Gln Asn Gly Asp Leu Leu Leu Thr Ala Arg Leu Asp Phe Asn Gln 
625                 630                 635                 640 


Ile Val Asn Gly Val Asn Tyr Ser Pro Arg Gln Gln Phe Leu Ser Lys 
                645                 650                 655     


Asp Gly Gly Ile Thr Trp Ser Leu Leu Glu Ala Asn Asn Ala Asn Val 
            660                 665                 670         


Phe Ser Asn Ile Ser Thr Gly Thr Val Asp Ala Ser Ile Thr Arg Phe 
        675                 680                 685             


Glu Gln Ser Asp Gly Ser His Phe Leu Leu Phe Thr Asn Pro Gln Gly 
    690                 695                 700                 


Asn Pro Ala Gly Thr Asn Gly Arg Gln Asn Leu Gly Leu Trp Phe Ser 
705                 710                 715                 720 


Phe Asp Glu Gly Val Thr Trp Lys Gly Pro Ile Gln Leu Val Asn Gly 
                725                 730                 735     


Ala Ser Ala Tyr Ser Asp Ile Tyr Gln Leu Asp Ser Glu Asn Ala Ile 
            740                 745                 750         


Val Ile Val Glu Thr Asp Asn Ser Asn Met Arg Ile Leu Arg Met Pro 
        755                 760                 765             


Ile Thr Leu Leu Lys Gln Lys Leu Thr Leu Ser Gln Asn 
    770                 775                 780     


<210>  2
<211>  1035
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  2

Met Ser Tyr Phe Arg Asn Arg Asp Ile Asp Ile Glu Arg Asn Ser Met 
1               5                   10                  15      


Asn Arg Ser Val Gln Glu Arg Lys Cys Arg Tyr Ser Ile Arg Lys Leu 
            20                  25                  30          


Ser Val Gly Ala Val Ser Met Ile Val Gly Ala Val Val Phe Gly Thr 
        35                  40                  45              


Ser Pro Val Leu Ala Gln Glu Gly Ala Ser Glu Gln Pro Leu Ala Asn 
    50                  55                  60                  


Glu Thr Gln Leu Ser Gly Glu Ser Ser Thr Leu Thr Asp Thr Glu Lys 
65                  70                  75                  80  


Ser Gln Pro Ser Ser Glu Thr Glu Leu Ser Gly Asn Lys Gln Glu Gln 
                85                  90                  95      


Glu Arg Lys Asp Lys Gln Glu Glu Lys Ile Pro Arg Asp Tyr Tyr Ala 
            100                 105                 110         


Arg Asp Leu Glu Asn Val Glu Thr Val Ile Glu Lys Glu Asp Val Glu 
        115                 120                 125             


Thr Asn Ala Ser Asn Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp 
    130                 135                 140                 


Lys Leu Lys Lys Leu Glu Asn Ala Thr Val His Met Glu Phe Lys Pro 
145                 150                 155                 160 


Asp Ala Lys Ala Pro Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala 
                165                 170                 175     


Thr Lys Lys Asp Glu Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala 
            180                 185                 190         


Thr Leu Glu Gly Arg Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr 
        195                 200                 205             


Asn Asp Ala Pro Leu Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr 
    210                 215                 220                 


Phe Thr Val Glu Lys Pro Thr Ala Glu Leu Pro Lys Gly Arg Val Arg 
225                 230                 235                 240 


Leu Tyr Val Asn Gly Val Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn 
                245                 250                 255     


Phe Ile Lys Asp Met Pro Asp Val Thr His Val Gln Ile Gly Ala Thr 
            260                 265                 270         


Lys Arg Ala Asn Asn Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn 
        275                 280                 285             


Leu Thr Val Tyr Asn Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg 
    290                 295                 300                 


Ser Gln Leu Phe Lys Arg Ser Asp Leu Glu Lys Lys Leu Pro Glu Gly 
305                 310                 315                 320 


Ala Ala Leu Thr Glu Lys Thr Asp Ile Phe Glu Ser Gly Arg Asn Gly 
                325                 330                 335     


Lys Pro Asn Lys Asp Gly Ile Lys Ser Tyr Arg Ile Pro Ala Leu Leu 
            340                 345                 350         


Lys Thr Asp Lys Gly Thr Leu Ile Ala Gly Ala Asp Glu Arg Arg Leu 
        355                 360                 365             


His Ser Ser Asp Trp Gly Asp Ile Gly Met Val Ile Arg Arg Ser Glu 
    370                 375                 380                 


Asp Asn Gly Lys Thr Trp Gly Asp Arg Val Thr Ile Thr Asn Leu Arg 
385                 390                 395                 400 


Asp Asn Pro Lys Ala Ser Asp Pro Ser Ile Gly Ser Pro Val Asn Ile 
                405                 410                 415     


Asp Met Val Leu Val Gln Asp Pro Glu Thr Lys Arg Ile Phe Ser Ile 
            420                 425                 430         


Tyr Asp Met Phe Pro Glu Gly Lys Gly Ile Phe Gly Met Ser Ser Gln 
        435                 440                 445             


Lys Glu Glu Ala Tyr Lys Lys Ile Asp Gly Lys Thr Tyr Gln Ile Leu 
    450                 455                 460                 


Tyr Arg Glu Gly Glu Lys Gly Ala Tyr Thr Ile Arg Glu Asn Gly Thr 
465                 470                 475                 480 


Val Tyr Thr Pro Asp Gly Lys Ala Thr Asp Tyr Arg Val Val Val Asp 
                485                 490                 495     


Pro Val Lys Pro Ala Tyr Ser Asp Lys Gly Asp Leu Tyr Lys Gly Asn 
            500                 505                 510         


Gln Leu Leu Gly Asn Ile Tyr Phe Thr Thr Asn Lys Thr Ser Pro Phe 
        515                 520                 525             


Arg Ile Ala Lys Asp Ser Tyr Leu Trp Met Ser Tyr Ser Asp Asp Asp 
    530                 535                 540                 


Gly Lys Thr Trp Ser Ala Pro Gln Asp Ile Thr Pro Met Val Lys Ala 
545                 550                 555                 560 


Asp Trp Met Lys Phe Leu Gly Val Gly Pro Gly Thr Gly Ile Val Leu 
                565                 570                 575     


Arg Asn Gly Pro His Lys Gly Arg Ile Leu Ile Pro Val Tyr Thr Thr 
            580                 585                 590         


Asn Asn Val Ser His Leu Asn Gly Ser Gln Ser Ser Arg Ile Ile Tyr 
        595                 600                 605             


Ser Asp Asp His Gly Lys Thr Trp His Ala Gly Glu Ala Val Asn Asp 
    610                 615                 620                 


Asn Arg Gln Val Asp Gly Gln Lys Ile His Ser Ser Thr Met Asn Asn 
625                 630                 635                 640 


Arg Arg Ala Gln Asn Thr Glu Ser Thr Val Val Gln Leu Asn Asn Gly 
                645                 650                 655     


Asp Val Lys Leu Phe Met Arg Gly Leu Thr Gly Asp Leu Gln Val Ala 
            660                 665                 670         


Thr Ser Lys Asp Gly Gly Val Thr Trp Glu Lys Asp Ile Lys Arg Tyr 
        675                 680                 685             


Pro Gln Val Lys Asp Val Tyr Val Gln Met Ser Ala Ile His Thr Met 
    690                 695                 700                 


His Glu Gly Lys Glu Tyr Ile Ile Leu Ser Asn Ala Gly Gly Pro Lys 
705                 710                 715                 720 


Arg Glu Asn Gly Met Val His Leu Ala Arg Val Glu Glu Asn Gly Glu 
                725                 730                 735     


Leu Thr Trp Leu Lys His Asn Pro Ile Gln Lys Gly Glu Phe Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gln Glu Leu Gly Asn Gly Glu Tyr Gly Ile Leu Tyr Glu 
        755                 760                 765             


His Thr Glu Lys Gly Gln Asn Ala Tyr Thr Leu Ser Phe Arg Lys Phe 
    770                 775                 780                 


Asn Trp Asp Phe Leu Ser Lys Asp Leu Ile Ser Pro Thr Glu Ala Lys 
785                 790                 795                 800 


Val Lys Arg Thr Arg Glu Met Gly Lys Gly Val Ile Gly Leu Glu Phe 
                805                 810                 815     


Asp Ser Glu Val Leu Val Asn Lys Ala Pro Thr Leu Gln Leu Ala Asn 
            820                 825                 830         


Gly Lys Thr Ala Arg Phe Met Thr Gln Tyr Asp Thr Lys Thr Leu Leu 
        835                 840                 845             


Phe Thr Val Asp Ser Glu Asp Met Gly Gln Lys Val Thr Gly Leu Ala 
    850                 855                 860                 


Glu Gly Ala Ile Glu Ser Met His Asn Leu Pro Val Ser Val Ala Gly 
865                 870                 875                 880 


Thr Lys Leu Ser Asn Gly Met Asn Gly Ser Glu Ala Ala Val His Glu 
                885                 890                 895     


Val Pro Glu Tyr Thr Gly Pro Leu Gly Thr Ser Gly Glu Glu Pro Ala 
            900                 905                 910         


Pro Thr Val Glu Lys Pro Glu Tyr Thr Gly Pro Leu Gly Thr Ser Gly 
        915                 920                 925             


Glu Glu Pro Ala Pro Thr Val Glu Lys Pro Glu Tyr Thr Gly Pro Leu 
    930                 935                 940                 


Gly Thr Ala Gly Glu Glu Ala Ala Pro Thr Val Glu Lys Pro Glu Phe 
945                 950                 955                 960 


Thr Gly Gly Val Asn Gly Thr Glu Pro Ala Val His Glu Ile Ala Glu 
                965                 970                 975     


Tyr Lys Gly Ser Asp Ser Leu Val Thr Leu Thr Thr Lys Glu Asp Tyr 
            980                 985                 990         


Thr Tyr Lys Ala Pro Leu Ala Gln  Gln Ala Leu Pro Glu  Thr Gly Asn 
        995                 1000                 1005             


Lys Glu  Ser Asp Leu Leu Ala  Ser Leu Gly Leu Thr  Ala Phe Phe 
    1010                 1015                 1020             


Leu Gly  Leu Phe Thr Leu Gly  Lys Lys Arg Glu Gln  
    1025                 1030                 1035 


<210>  3
<211>  185
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  3

Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn Gly Gln Arg 
1               5                   10                  15      


Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu Glu Asn Ala 
            20                  25                  30          


Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro Ala Phe Tyr 
        35                  40                  45              


Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu Tyr Phe Thr 
    50                  55                  60                  


Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg Gly Ser Asp 
65                  70                  75                  80  


Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu Lys Val Lys 
                85                  90                  95      


Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys Pro Thr Ala 
            100                 105                 110         


Glu Leu Pro Lys Gly Arg Val Arg Leu Tyr Val Asn Gly Val Leu Ser 
        115                 120                 125             


Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met Pro Asp Val 
    130                 135                 140                 


Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn Thr Val Trp 
145                 150                 155                 160 


Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn Arg Ala Leu 
                165                 170                 175     


Thr Pro Glu Glu Val Gln Lys Arg Ser 
            180                 185 


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4

Ala Leu Asn Gly Ser 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  5

Leu Gln Ala Leu Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  6

Gly Gly Asn Ser Gly 
1               5   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  7

Ala Leu Asn Gly Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  8

Leu Gln Ala Leu Gly Gly Gly Gly Ser Leu 
1               5                   10  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  9

Ala Leu Asn Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15  


<210>  10
<211>  438
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  10

Met Asn Thr Tyr Phe Asp Ile Pro His Arg Leu Val Gly Lys Ala Leu 
1               5                   10                  15      


Tyr Glu Ser Tyr Tyr Asp His Phe Gly Gln Met Asp Ile Leu Ser Asp 
            20                  25                  30          


Gly Ser Leu Tyr Leu Ile Tyr Arg Arg Ala Thr Glu His Val Gly Gly 
        35                  40                  45              


Ser Asp Gly Arg Val Val Phe Ser Lys Leu Glu Gly Gly Ile Trp Ser 
    50                  55                  60                  


Ala Pro Thr Ile Val Ala Gln Ala Gly Gly Gln Asp Phe Arg Asp Val 
65                  70                  75                  80  


Ala Gly Gly Thr Met Pro Ser Gly Arg Ile Val Ala Ala Ser Thr Val 
                85                  90                  95      


Tyr Glu Thr Gly Glu Val Lys Val Tyr Val Ser Asp Asp Ser Gly Val 
            100                 105                 110         


Thr Trp Val His Lys Phe Thr Leu Ala Arg Gly Gly Ala Asp Tyr Asn 
        115                 120                 125             


Phe Ala His Gly Lys Ser Phe Gln Val Gly Ala Arg Tyr Val Ile Pro 
    130                 135                 140                 


Leu Tyr Ala Ala Thr Gly Val Asn Tyr Glu Leu Lys Trp Leu Glu Ser 
145                 150                 155                 160 


Ser Asp Gly Gly Glu Thr Trp Gly Glu Gly Ser Thr Ile Tyr Ser Gly 
                165                 170                 175     


Asn Thr Pro Tyr Asn Glu Thr Ser Tyr Leu Pro Val Gly Asp Gly Val 
            180                 185                 190         


Ile Leu Ala Val Ala Arg Val Gly Ser Gly Ala Gly Gly Ala Leu Arg 
        195                 200                 205             


Gln Phe Ile Ser Leu Asp Asp Gly Gly Thr Trp Thr Asp Gln Gly Asn 
    210                 215                 220                 


Val Thr Ala Gln Asn Gly Asp Ser Thr Asp Ile Leu Val Ala Pro Ser 
225                 230                 235                 240 


Leu Ser Tyr Ile Tyr Ser Glu Gly Gly Thr Pro His Val Val Leu Leu 
                245                 250                 255     


Tyr Thr Asn Arg Thr Thr His Phe Cys Tyr Tyr Arg Thr Ile Leu Leu 
            260                 265                 270         


Ala Lys Ala Val Ala Gly Ser Ser Gly Trp Thr Glu Arg Val Pro Val 
        275                 280                 285             


Tyr Ser Ala Pro Ala Ala Ser Gly Tyr Thr Ser Gln Val Val Leu Gly 
    290                 295                 300                 


Gly Arg Arg Ile Leu Gly Asn Leu Phe Arg Glu Thr Ser Ser Thr Thr 
305                 310                 315                 320 


Ser Gly Ala Tyr Gln Phe Glu Val Tyr Leu Gly Gly Val Pro Asp Phe 
                325                 330                 335     


Glu Ser Asp Trp Phe Ser Val Ser Ser Asn Ser Leu Tyr Thr Leu Ser 
            340                 345                 350         


His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val Glu Phe Ala Arg 
        355                 360                 365             


Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro Ser Tyr Phe Asn 
    370                 375                 380                 


Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu Val Gly Ser Leu 
385                 390                 395                 400 


Asn Ile Arg Leu Gly Thr Gly Ala Ala Val Trp Gly Thr Gly Tyr Phe 
                405                 410                 415     


Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala Thr Gly Tyr Tyr 
            420                 425                 430         


Arg Val Arg Ala Trp Ile 
        435             


