                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
       Yeda Research and Development Company, Ltd.
 
<120>  Treatment and Prevention of Malaria

<130>  P47741WO

<150>  GB1615298.5
<151>  2016-09-08

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
    450                 455                 460                 


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  2
<211>  526
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
    450                 455                 460                 


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  3
<211>  387
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Ala 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr 
                245                 250                 255     


Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  4
<211>  387
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Ala 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr 
                245                 250                 255     


Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  5
<211>  367
<212>  PRT
<213>  Plasmodium falciparum

<400>  5

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Ala Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Ala Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser 
    290                 295                 300                 


Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  6
<211>  367
<212>  PRT
<213>  Plasmodium falciparum

<400>  6

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Ala Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Ala Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser 
    290                 295                 300                 


Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  7
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 (3D7) sequence excluding flexible N-terminal (1-139) and 
       flexible loop regions

<400>  7

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn 
        195                 200                 205             


Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  8
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 (7G8) sequence excluding flexible N-terminal (1-139) and 
       flexible loop regions

<400>  8

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn 
        195                 200                 205             


Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  9
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 (3D7) sequence excluding flexible N-terminal (1-159) and 
       flexible loop regions

<400>  9

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
                245                 250                 255     


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  10
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PfRH5 (7G8) sequence excluding flexible N-terminal (1-159) and 
       flexible loop regions

<400>  10

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Ser Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu Thr Asn Leu Asn Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ser Asn 
                245                 250                 255     


Glu Tyr Ser Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  11
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sv2 (3D7) sequence excluding flexible N-terminal (1-139) region, 
       with Bip leader and Hexa-His tag

<400>  11

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp 
        115                 120                 125             


Asp Ser Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu 
    130                 135                 140                 


Glu Thr Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr 
145                 150                 155                 160 


Asp Ser Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn 
                165                 170                 175     


Arg Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys 
            180                 185                 190         


Leu Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys 
        195                 200                 205             


Met Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys 
    210                 215                 220                 


Tyr Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp 
225                 230                 235                 240 


Glu Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn 
                245                 250                 255     


Lys Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu 
            260                 265                 270         


Leu Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr 
        275                 280                 285             


Ile Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu 
    290                 295                 300                 


Tyr His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys 
305                 310                 315                 320 


Ile Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys 
                325                 330                 335     


Arg Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp 
            340                 345                 350         


His Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His 
        355                 360                 365             


Leu Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe 
    370                 375                 380                 


Asn Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn 
385                 390                 395                 400 


Lys Pro Leu Thr Gln His His His His His His 
                405                 410     


<210>  12
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sv2 (7G8) sequence excluding flexible N-terminal (1-139) region, 
       with Bip leader and Hexa-His tag

<400>  12

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp 
        115                 120                 125             


Asp Ser Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu 
    130                 135                 140                 


Glu Thr Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr 
145                 150                 155                 160 


Asp Ser Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn 
                165                 170                 175     


Arg Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys 
            180                 185                 190         


Leu Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys 
        195                 200                 205             


Met Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys 
    210                 215                 220                 


Tyr Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp 
225                 230                 235                 240 


Glu Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn 
                245                 250                 255     


Lys Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu 
            260                 265                 270         


Leu Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr 
        275                 280                 285             


Ile Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu 
    290                 295                 300                 


Tyr His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys 
305                 310                 315                 320 


Ile Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys 
                325                 330                 335     


Arg Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp 
            340                 345                 350         


His Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His 
        355                 360                 365             


Leu Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe 
    370                 375                 380                 


Asn Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn 
385                 390                 395                 400 


Lys Pro Leu Thr Gln His His His His His His 
                405                 410     


<210>  13
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sv3 (3D7) sequence excluding flexible N-terminal (1-139) and 
       flexible loop regions, with Bip leader and Hexa-His tag

<400>  13

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu 
    210                 215                 220                 


Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn 
                325                 330                 335     


Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln His His His His His His 
        355                 360         


<210>  14
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sv3 (7G8) sequence excluding flexible N-terminal (1-139) and 
       flexible loop regions, with Bip leader and Hexa-His tag

<400>  14

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Ala 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu Leu Leu 
    210                 215                 220                 


Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser Asp His 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn 
                325                 330                 335     


Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln His His His His His His 
        355                 360         


<210>  15
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (3D7) including 
       signal sequence

<400>  15

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Leu Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Phe 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  16
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (7G8) including 
       signal sequence

<400>  16

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Leu Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn Ser 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Phe 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  17
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  17

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile 
                165                 170                 175     


Asn Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn 
                245                 250                 255     


Asn Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile 
305                 310                 315                 320 


Leu Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  18
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  18

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile 
                165                 170                 175     


Asn Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn 
                245                 250                 255     


Asn Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile 
305                 310                 315                 320 


Leu Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp 
        355                 360                 365             


Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  19
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  19

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  20
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  20

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  21
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  21

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn 
        195                 200                 205             


Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu 
            260                 265                 270         


Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  22
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  22

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Phe 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  23
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminaland flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  23

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn 
        195                 200                 205             


Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu 
            260                 265                 270         


Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val 
305                 310                 315                 320 


Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln His His His His His His 
            340                 


<210>  24
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  24

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Asn 
            20                  25                  30          


Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Phe 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met Ser Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Lys Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln His His 
305                 310                 315                 320 


His His His His 
                


<210>  25
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  25

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe 
    130                 135                 140                 


Ile Asn Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu 
    210                 215                 220                 


Asn Asn Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys 
        275                 280                 285             


Ile Leu Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn 
                325                 330                 335     


Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln 
        355     


<210>  26
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  26

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met 
            260                 265                 270         


Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile 
305                 310                 315                 320 


Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


<210>  27
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  27

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Leu Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe 
    130                 135                 140                 


Ile Asn Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu 
    210                 215                 220                 


Asn Asn Leu Glu Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys 
        275                 280                 285             


Ile Leu Asp Met Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn 
                325                 330                 335     


Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln His His His His His His 
        355                 360         


<210>  28
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  28

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Lys Thr Ile Lys Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Phe Asp Glu Tyr Asn Thr Lys Lys Asn Lys Phe Ile Asn Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Asn Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Leu Ala Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Lys Asn Ile Leu Gln Gln Ser Glu Lys Leu Leu Asn Asn Leu Glu 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asn Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Lys Ile Leu Asp Met 
            260                 265                 270         


Ser Lys Glu Tyr Ala Leu Phe Ile Thr Ser Asp His Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


His His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile 
305                 310                 315                 320 


Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


His His His His His His 
            340         


<210>  29
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (3D7) including 
       signal sequence

<400>  29

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile Ala 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  30
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (7G8) including 
       signal sequence

<400>  30

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile Ala 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  31
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  31

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg 
                245                 250                 255     


Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Glu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp 
        355                 360                 365             


Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  32
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  32

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg 
                245                 250                 255     


Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Glu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp 
        355                 360                 365             


Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  33
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  33

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  34
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  34

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  35
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  35

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn 
        195                 200                 205             


Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu 
                245                 250                 255     


Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val 
305                 310                 315                 320 


Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  36
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  36

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  37
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  37

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn 
        195                 200                 205             


Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu 
                245                 250                 255     


Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val 
305                 310                 315                 320 


Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln His His His His His His 
            340                 


<210>  38
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  38

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Lys 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe Asn His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile Pro Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln His His 
305                 310                 315                 320 


His His His His 
                


<210>  39
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  39

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn 
            100                 105                 110         


Thr Ile His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu 
    210                 215                 220                 


Arg Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Glu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn 
                325                 330                 335     


Asp Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln 
        355     


<210>  40
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  40

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met 
            260                 265                 270         


Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile 
305                 310                 315                 320 


Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


<210>  41
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  41

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn 
            100                 105                 110         


Thr Ile His Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu 
    210                 215                 220                 


Arg Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile Leu Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Glu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn 
                325                 330                 335     


Asp Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln His His His His His His 
        355                 360         


<210>  42
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS2 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  42

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile His Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Met Asp Glu Tyr Lys Thr Lys Lys Lys Lys Phe Ile Lys Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Asn Lys Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Lys Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Arg Asn Leu Lys 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile Leu 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Glu Asp Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met 
            260                 265                 270         


Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


Asn His Leu Ile Tyr Val Leu Gln Met Lys Leu Asn Asp Val Pro Ile 
305                 310                 315                 320 


Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


His His His His His His 
            340         


<210>  43
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (3D7) including 
       signal sequence

<400>  43

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile Ala 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  44
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified full length PfRH5 amino acid sequence (7G8) including 
       signal sequence

<400>  44

Met Ile Arg Ile Lys Lys Lys Leu Ile Leu Thr Ile Ile Tyr Ile His 
1               5                   10                  15      


Leu Phe Ile Leu Asn Arg Leu Ser Phe Glu Asn Ala Ile Lys Lys Thr 
            20                  25                  30          


Lys Asn Gln Glu Asn Asn Leu Thr Leu Leu Pro Ile Lys Ser Thr Glu 
        35                  40                  45              


Glu Glu Lys Asp Asp Ile Lys Asn Gly Lys Asp Ile Lys Lys Glu Ile 
    50                  55                  60                  


Asp Asn Asp Lys Glu Asn Ile Lys Thr Asn Asn Ala Lys Asp His Ser 
65                  70                  75                  80  


Thr Tyr Ile Lys Ser Tyr Leu Asn Thr Asn Val Asn Asp Gly Leu Lys 
                85                  90                  95      


Tyr Leu Phe Ile Pro Ser His Asn Ser Phe Ile Lys Lys Tyr Ser Val 
            100                 105                 110         


Phe Asn Gln Ile Asn Asp Gly Met Leu Leu Asn Glu Lys Asn Asp Val 
        115                 120                 125             


Lys Asn Asn Glu Asp Tyr Lys Asn Val Asp Tyr Lys Asn Val Asn Phe 
    130                 135                 140                 


Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr Asn Ile Ala Asn Ser 
145                 150                 155                 160 


Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile Ile 
                165                 170                 175     


Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile Ala 
            180                 185                 190         


Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp Ala 
        195                 200                 205             


Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys Cys 
    210                 215                 220                 


Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu His 
225                 230                 235                 240 


Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp Ile 
                245                 250                 255     


Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr Glu 
            260                 265                 270         


Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro Ser 
        275                 280                 285             


Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met Met 
    290                 295                 300                 


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
305                 310                 315                 320 


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
                325                 330                 335     


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
            340                 345                 350         


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
        355                 360                 365             


Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Thr 
    370                 375                 380                 


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys Lys 
385                 390                 395                 400 


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
                405                 410                 415     


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
            420                 425                 430         


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp Arg 
        435                 440                 445             


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
    450                 455                 460                 


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
465                 470                 475                 480 


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
                485                 490                 495     


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro Met 
            500                 505                 510         


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        515                 520                 525     


<210>  45
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  45

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr 
                245                 250                 255     


Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  46
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  46

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser 
            100                 105                 110         


Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr 
        115                 120                 125             


Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser 
    130                 135                 140                 


Asn His Thr Pro Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr 
145                 150                 155                 160 


Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile 
                165                 170                 175     


Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp 
            180                 185                 190         


Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn 
        195                 200                 205             


Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr 
    210                 215                 220                 


Ile His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp 
225                 230                 235                 240 


Leu Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr 
                245                 250                 255     


Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys 
            260                 265                 270         


Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His 
        275                 280                 285             


Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys 
    290                 295                 300                 


Leu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile 
305                 310                 315                 320 


Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu 
                325                 330                 335     


Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn 
            340                 345                 350         


Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp 
        355                 360                 365             


Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro 
    370                 375                 380                 


Leu Thr Gln 
385         


<210>  47
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (3D7) excluding signal 
       sequence and flexible N-terminal region

<400>  47

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Cys Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  48
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified PfRH5 amino acid sequence (7G8) excluding signal 
       sequence and flexible N-terminal region

<400>  48

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Thr Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Asp Asp Ser Tyr Arg Tyr Asp 
                85                  90                  95      


Ile Ser Glu Glu Ile Asp Asp Lys Ser Glu Glu Thr Asp Asp Glu Thr 
            100                 105                 110         


Glu Glu Val Glu Asp Ser Ile Gln Asp Thr Asp Ser Asn His Thr Pro 
        115                 120                 125             


Ser Asn Lys Lys Lys Asn Asp Leu Met Asn Arg Thr Phe Lys Lys Met 
    130                 135                 140                 


Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys 
145                 150                 155                 160 


Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr 
                165                 170                 175     


Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys 
            180                 185                 190         


Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu 
        195                 200                 205             


Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met 
    210                 215                 220                 


Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys 
225                 230                 235                 240 


Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys 
                245                 250                 255     


Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile 
            260                 265                 270         


Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp 
        275                 280                 285             


Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala 
    290                 295                 300                 


Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu 
305                 310                 315                 320 


Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His 
                325                 330                 335     


His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro 
            340                 345                 350         


Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
        355                 360                 365         


<210>  49
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  49

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn 
        195                 200                 205             


Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln 
        


<210>  50
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop

<400>  50

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
305                 310                 315             


<210>  51
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  51

Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser Asn Tyr 
1               5                   10                  15      


Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu 
            20                  25                  30          


Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His 
        35                  40                  45              


Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr 
    50                  55                  60                  


Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys 
65                  70                  75                  80  


Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile 
                85                  90                  95      


Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe 
            100                 105                 110         


Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys 
        115                 120                 125             


Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met 
    130                 135                 140                 


Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn 
145                 150                 155                 160 


Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile 
                165                 170                 175     


His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu 
            180                 185                 190         


Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn 
        195                 200                 205             


Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe 
    210                 215                 220                 


Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr 
225                 230                 235                 240 


Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu 
                245                 250                 255     


Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu 
            260                 265                 270         


Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg 
        275                 280                 285             


Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn 
    290                 295                 300                 


Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val 
305                 310                 315                 320 


Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu 
                325                 330                 335     


Thr Gln His His His His His His 
            340                 


<210>  52
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Hexa-histidine C-terminal tag

<400>  52

Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe Val Ile 
1               5                   10                  15      


Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser Tyr Ile 
            20                  25                  30          


Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala Val Asp 
        35                  40                  45              


Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys Ser Lys 
    50                  55                  60                  


Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys Leu Glu 
65                  70                  75                  80  


His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys Met Met 
                85                  90                  95      


Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile Lys Asn 
            100                 105                 110         


His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn Tyr Gly 
        115                 120                 125             


Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe Cys Asn 
    130                 135                 140                 


Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys Leu Ile 
145                 150                 155                 160 


Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp Met Thr 
                165                 170                 175     


Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys Lys Lys 
            180                 185                 190         


Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His Lys Glu 
        195                 200                 205             


Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile Ile Asn 
    210                 215                 220                 


Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile Trp Arg 
225                 230                 235                 240 


Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met Ala Lys 
                245                 250                 255     


Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met Leu Tyr 
            260                 265                 270         


Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe His His 
        275                 280                 285             


Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile Pro Met 
    290                 295                 300                 


Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln His His 
305                 310                 315                 320 


His His His His 
                


<210>  53
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  53

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu 
    210                 215                 220                 


Thr Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn 
                325                 330                 335     


Asp Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln 
        355     


<210>  54
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence

<400>  54

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met 
            260                 265                 270         


Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile 
305                 310                 315                 320 


Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


<210>  55
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  55

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu Ser 
            20                  25                  30          


Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly 
        35                  40                  45              


His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr 
    50                  55                  60                  


Lys His Leu Ser Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly 
65                  70                  75                  80  


Lys Tyr Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr 
                85                  90                  95      


Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn 
            100                 105                 110         


Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg 
        115                 120                 125             


Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu 
    130                 135                 140                 


Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met 
145                 150                 155                 160 


Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr 
                165                 170                 175     


Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu 
            180                 185                 190         


Tyr Ile His Lys Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys 
        195                 200                 205             


Asp Leu Asn Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu 
    210                 215                 220                 


Thr Asn Leu Lys Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile 
225                 230                 235                 240 


Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr 
                245                 250                 255     


His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile 
            260                 265                 270         


Lys Leu Asp Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg 
        275                 280                 285             


Ile Leu Asp Met Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp 
    290                 295                 300                 


Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu 
305                 310                 315                 320 


Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn 
                325                 330                 335     


Asp Val Pro Ile Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys 
            340                 345                 350         


Pro Leu Thr Gln His His His His His His 
        355                 360         


<210>  56
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3 excluding signal sequence, flexible N-terminal and flexible 
       loop and comprising a Bip leader sequence and a Hexa-histidine 
       C-terminal tag

<400>  56

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Ser Ile Asp Ile Leu Gln Glu Lys Glu Gly His Leu Asp Phe 
            20                  25                  30          


Val Ile Ile Pro His Tyr Thr Phe Leu Glu Tyr Tyr Lys His Leu Ser 
        35                  40                  45              


Tyr Ile Ala Ile Tyr His Lys Ser Ser Thr Tyr Gly Lys Tyr Ile Ala 
    50                  55                  60                  


Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala Tyr Asp Lys Val Lys 
65                  70                  75                  80  


Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile Asn Thr Ile Lys Lys 
                85                  90                  95      


Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn Arg Ala Phe Lys Lys 
            100                 105                 110         


Met Met Asp Glu Tyr Asn Thr Lys Lys Lys Lys Leu Ile Lys Cys Ile 
        115                 120                 125             


Lys Asn His Glu Asn Asp Phe Asn Lys Ile Cys Met Asp Met Lys Asn 
    130                 135                 140                 


Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser Cys Tyr Asn Asn Asn Phe 
145                 150                 155                 160 


Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr Asp Glu Tyr Ile His Lys 
                165                 170                 175     


Leu Ile Asn Ser Val Lys Ser Lys Asn Leu Asn Lys Asp Leu Asn Asp 
            180                 185                 190         


Met Thr Asn Ile Leu Gln Gln Ser Glu Asp Leu Leu Thr Asn Leu Lys 
        195                 200                 205             


Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp Thr Ile Lys Phe Ile His 
    210                 215                 220                 


Lys Glu Met Lys His Ile Phe Asn Arg Ile Glu Tyr His Thr Lys Ile 
225                 230                 235                 240 


Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp Lys Ile Lys Leu Asp Ile 
                245                 250                 255     


Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu Lys Arg Ile Leu Asp Met 
            260                 265                 270         


Ala Lys Glu Tyr Ala Leu Phe Arg Thr Ser Asp Asp Leu Arg Gln Met 
        275                 280                 285             


Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys His Leu Asn Asn Ile Phe 
    290                 295                 300                 


His His Leu Ile Tyr Val Leu Gln Met Lys Phe Asn Asp Val Pro Ile 
305                 310                 315                 320 


Pro Met Glu Tyr Phe Gln Thr Tyr Lys Lys Asn Lys Pro Leu Thr Gln 
                325                 330                 335     


His His His His His His 
            340         


