                         SEQUENCE LISTING

<110>  Universit de Strasbourg et al
       CNRS
       INSERM
 
<120>  Recombinant Dgkk gene for fragile X syndrome gene therapy

<130>  B2326PC

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  3816
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Proline Rich Region
<222>  (70)..(132)

<220>
<221>  EPAPE repeated region
<222>  (142)..(539)

<400>  1
atggaccgcg gagctgccgc agcccagggc actgccccgc ctcaggatgg agagcagccc       60

gctgagtctc cagagcctcc gccgccttgg ccgccgccgc caccaccacc ggctccgccg      120

ccggctccgc cgctgctctc cgaggcttcg ccagaaccca taccagagcc ctgtccagag      180

cttgctccag gtccctgtcc agaggcgacc tcagaatcag ccacagaact gtacacagaa      240

ccgaccccag aaccagccac agagccggcc tcagaaccgg ccccagaacc tgccacagag      300

ccggccccag aacctgccac agagccggcc ccagaaccgg ccccagaacc tgccacagag      360

tctgccccag agccgactcc agaacctgcc ctagagtcgg tcccagagcc ggccccagag      420

ctgactccag aagttgcccc agagctggcc ccagagccga ccccagaacc tgtgacagag      480

ctggccccag agttctgccc tgaggcggct ccagagttcc gtccaagtcc agcaccatgt      540

ctattgcaat gtccggtgga cactcgagag agaggtctaa agacctcgcc atcgccatcg      600

ccatcgccat cgcccagaac gccaatgtcg tggtccagaa taaagaaaat attgaaggaa      660

ggacctatgc tgaagaactg taactctttc aagagatgga agcttagata ttttctggtt      720

caaggacaga agctctactt tgcacaccat cccgcgtttg cacactttga aacgattgat      780

ctgtctcaag ccactgtggc agaaagcagc tgtagaaacc tttgccacag tttttgtgtt      840

attacaccac aacgaaaaat cactctggct gcacccaacc ggaaagacat ggaagaatgg      900

attaacatca taaaaaccat ccaacaggga gaaatttata agatacctgc agcagaaaac      960

aacccttttc ttgttggaat gcattgttgg tactccagtt acagccaccg gacccagcac     1020

tgcaatgttt gtcgagagag cattcctgcc ttatctagag atgccatcat ctgtgaagtg     1080

tgcaaagtga aatctcacag attgtgtgct ttgagagcaa gcaaagactg caagtggaat     1140

acattgtcta tcactgatga cctccttctg cctgcagatg aagtaaacat gccccatcaa     1200

tgggtagaag gaaacatgcc tgtcagctct cagtgtgcag tgtgtcatga gagctgtggc     1260

agttatcaaa gacttcaaga cttccgctgc ctgtggtgta attctacggt gcatgatgac     1320

tgtaggagac ggttttccaa ggaatgttgc ttcagaagcc atcgctcatc agtcattcct     1380

cccactgctc taagcgaccc caaaggcgat ggccaattag tagtatcttc agacttctgg     1440

aatcttgatt ggtcatcagc ctgttcatgt cccttgctca tcttcatcaa ctccaaaagt     1500

ggcgatcatc aggggatcgt cttcctccga aaattcaagc aataccttaa cccatctcaa     1560

gtgttcgact tattgaaggg tggacctgaa gcagggctgt ctatgttcaa gaactttgct     1620

cgctttcgca ttctggtttg tggtggagat ggcagcgtga gctgggtctt atctctgatt     1680

gatgcctttg gattacatga aaagtgtcag ttggcagtca tcccacttgg aaccggcaat     1740

gatctggctc gtgttctggg ctggggtgca ttctggaaca aaagcaagtc acctctggac     1800

atcctcaaca gagtggagca ggctagtgtg aggatcctag acagatggag tgtgatgatt     1860

cgtgagactc ccagacaaac cccgctgcta aaaggacagg ttgaaatgga tgtaccacga     1920

tttgaggctg ctgccatcca acacttagaa tctgcagcca ccgagttgaa caaaatcctg     1980

aaggccaagt accccacaga gatgatcatc gcaaccagat tcttgtgttc agctgtggaa     2040

gattttgtgg ttgatattgt aaaggcctgg ggtcagataa aacagaacaa cactgcaata     2100

gtgtctgtga ttttgaaaag tgacttaatg tatgataggc tcagtgtcct gatcgatgtc     2160

ctggctgagg aggcagcagc tacttctgct gaaaaaagtg ctacagaata tgcagacagc     2220

agcaaggcag ataggaagcc cttcattcct caaatagacc acatagccaa gtgcaagttg     2280

gagctggcta caaaggccca gagtctccag aaatccttga aactcatcat atttcaagtt     2340

gaacaagctc tggatgagga aagcagacag acaatatctg ttaagaactt tagttcaact     2400

ttcttcctgg aagatgaccc agaagatatt aaccagacaa gcccacgacg ccgttctcgt     2460

cgtggcactt tgtcttctat atcttctctc aaaagtgagg acctggacaa ccttaacttg     2520

gatcacttac attttacacc tgaatctata cgcttcaaag aaaaatgtgt catgaacaac     2580

tacttcggaa ttggactgga tgctaaaatt tctctggact tcaacaccag aagagatgaa     2640

cacccagggc aatacaatag ccgccttaag aacaagatgt ggtatggcct tctgggaacc     2700

aaagaacttt tgcagcgctc ttacaggaaa ctggaagaac gagtgcattt ggagtgtgat     2760

ggagaaacca tctccttgcc aaacctgcaa ggcattgtag tgctcaacat taccagctat     2820

gctggaggta tcaacttctg gggaagcaac acagcaacca cggaatatga ggctcctgca     2880

atcgatgatg ggaaactgga ggtggtggca atctttggtt ctgtgcagat ggcaatgtcc     2940

cgtatcatca acctgcatca tcatcgcatt gcccagtgcc atgaggtgat gataaccatt     3000

gatggtgaag aaggtatccc agtgcaggtg gatggggagg cctggattca gagaccaggc     3060

cttatcaaaa ttagatacaa gaacgctgcc cagatgctga caagagatcg ggactttgag     3120

aactcaatga aaatgtggga atacaagcat actgaaattc aagctgcccc tcaaccccag     3180

ctggacttcc aggactctca agagagcctc tctgacgagg agtatgccca gatgcagcac     3240

ttagctcggc ttgcagaaaa cctcatcagc aaacttaatg acctgagcaa gatccaccag     3300

catgtgtctg tcctcatggg ttctgtgaat gccagcgcta acatcctgaa tgatatattt     3360

tacggccaag acagtggcaa tgagatgggt gcagcttcct gtattcccat tgaaactcta     3420

agcagaaatg atgccgtaga tgttacattt agtcttaaag gtctctacga tgacaccaca     3480

gctttcctgg atgaaaagct gctgagaagt gctgaggatg agactgcact acaaagcgcc     3540

ctggatgcca tgaataagga gttcaaaaag ctatctgaga ttgactggat gaatccaatc     3600

tttgttccag aggaaaaatc ttcggacact gacagtagaa gcctcaggct gaaaattaag     3660

ttccccaaat tgggaaagaa aaaggtagaa gaggaacgca agcctaaatc aggccagagt     3720

gtccagagtt ttattggcaa tttatggcac cgcagacatc gtgaagatga agcagagggt     3780

gatgatcctc taacaccatc gagatctcaa ctgtag                               3816


<210>  2
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  2
gcagctagct ccttgaaagc tggaaggaga                                        30


<210>  3
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
aatagaatgc ggccgccagc ttcaacagca cttgtag                                37


<210>  4
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
ttctcaacta tacccatacg atgttccaga ttacgcttag tccttgaaag ctggaagg         58


<210>  5
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
tcaaggacta agcgtaatct ggaacatcgt atgggtatag ttgagaactt gaaggtgttg       60


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  6
ggaatgcact actggtattc c                                                 21


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  7
gcgcttagct gtaggattc                                                    19


<210>  8
<211>  8085
<212>  DNA
<213>  Mus musculus


<220>
<221>  5'UTR
<222>  (1)..(158)

<220>
<221>  Proline Rich Region
<222>  (231)..(350)

<220>
<221>  EPAPE repeated region
<222>  (351)..(857)

<220>
<221>  Tag HA
<222>  (4209)..(4235)

<220>
<221>  3'UTR
<222>  (4239)..(8085)

<400>  8
cttagacctc agagctgcgc tagccatgga gcgaagcggg tgcaaagttt ggcaccctgc       60

aaagggatgt cagataggag tgggtggacc gcccaagggc tctttagccc tctaagctta      120

gggaccccgg ctgcctggac ctcagacggt gtgctgcaat ggacggtgta gattcggtgg      180

cccagggcac tgcccagcct caggatggag agcagcctgc tgagtcccca gagccgccgc      240

cgccacctcc cgctccgccg cccgccccac cgcctccggc cccaccgcct ccggccccac      300

cgccgccggc cccaccaccg cctgctcctc caccattccc tgagccttct ccagaaccag      360

taccagagcc tgctctggga ccctgtccag aggcgactcc agaaccagcc acagaaacag      420

acgcaaaatc aaccccagag ccggccccga agccggactc agaaccggac tcggacccgg      480

ccctcgaacc agactcagag ccggccccag agccggaccc cgaaccagac tcagagccgg      540

ccccagagcc ggaccccgaa ccagactcag agccggcccc agagccggac cccgaaccag      600

actcagagcc ggccccagag ccggaccccg aaccagactc agagccggcc ccagagccgg      660

accccgaacc agactcagag ccggccccag agccggaccc cgaaccagac tcagaaccgg      720

ccccagaacc agtctcagag ccggccccag aacttgtccc agagctggcc tcggagccgg      780

ccccagaacc tgtcctagag ccaaccctag agttggcctc agaactggcc ctagaaccag      840

ccccagatcc tgccatggag agggccccag agtcctggcc agagccaact ccagagtcct      900

gtctaagaat gagtccagca ctacatctgt tgcaggtagt tcctggagag aaaagtggaa      960

cagcatctcc agtgctattg ccattgccgt cgcccaaacc gccaataacg tggtccagaa     1020

taaagaaaat actgaaggaa ggacccctgc tgaagaactg taactccttc agaagatgga     1080

agcttagata ctgtctggtt caagggcaga agctccactt tgcacaccat ccttcgtttg     1140

cacactttga aacaattgat ctgtctcaag ttgttttggc tgaaagtagc tgcagaaatc     1200

tttgccatgg tttttgtgtt atcacaccac atcgaaaagt gtctctagtt gcacccactc     1260

ggcaagacat ggaagaatgg attaacatca taaaaactgt ccaacaagga gaaatccgtc     1320

agatccctgc agccgaaaac aacccctttc ttgtcggaat gcactactgg tattccagta     1380

gtaatccccg gagtcacttc tgcaatgttt gtcgagagaa cattcctgct ttatctcgag     1440

atgccgtcac ctgtgaagtc tgtcaggtga aatctcataa attctgtgct ttgagagcaa     1500

acaaagactg taaatggaat actttatccg tgactgatga ccttcttcta cccgctgatg     1560

aaatacaaac aatgccgcat cagtgggtag aaggaaatat acccgctggc tctcaatgtg     1620

tcgtatgtca caagagctgc ggtagtcatc acagacttca ggatttccgc tgcctctggt     1680

gcggctctac ggtgcacggg gcctgccaga agcggttttc caaggaatgt tccttcggaa     1740

gtcgtcgctc gtccatcgtg ccaccaacgg cactgagcga ccctaggggc gatggccagc     1800

tagtagtatc gcctgacttc tggaatcttg actggccact gacttgttcc tgtcccttgc     1860

tcatcttcat caactctaaa agtggagatc atcaagggat catctttctc cggaaattca     1920

aacaatacct taatccgtct caagtattcg acctggcgaa gggtggacct gaagcaggca     1980

tcgctatgtt caagaacttt gcccgttttc gtgttctggt ttgtggtgga gatggcagtg     2040

tgagctgggt cttgtctacg attgatgcct atggattgca tgataggtgt cagctggcga     2100

tcatcccact tggaactggt aatgatctcg ctcgtgtcct gggctgggga gcagtctgga     2160

gtaaaggcac atcaccactg gatattctca gcagagtgga gcaggctcac gtgaggattt     2220

tagacagatg gagtgtgatg atccgtgaga cccccagaca agccccgctg ctgaaaggac     2280

aagtggcaat ggatatacca agatttgagg ctgctgccat caagaacgta gagtctgcaa     2340

ccactgagtt gaacaaaatt ctgaaggcca aatatcccac ggagatggtc atcgccacaa     2400

gattcctgtg ctcagcagtg gaagattttg tggaagatat tgtaaaggcc tggcaccaaa     2460

taaaacagaa cagcacagca gtggagtctg tgattttgaa aagcgactta atgtatgata     2520

aactcagtgt ccttattgat ctcctggctg aggatgcagt agctgcctcc gctgagagga     2580

cagccacagc atatggaagc agaagccaag cagatggaaa acccttcgtg cctcaactag     2640

accacatagc aagggccaaa ctggagttgg ctgaaagggc tcagaaactc cagcagtcct     2700

tgaaactcat catattccag gtcgaacaag ttctggatga agaaagcaga cagagcttat     2760

cagttaagaa ctttacttca tctttgttcc tgggagacgg agacgacgac gactcagatg     2820

actatgatca gagccctaga caccgttctc gttgtgacat cttatgttct ataccttctc     2880

tgagaaatga agacctagat aaccttgact tagaacactt acacattgca cctgaaacga     2940

tacgcttcaa agaaaagtgt gtcatgaaca actactttgg aattggacta gacgcaaaaa     3000

tctctctgga gtttaattcc agaagagaag aacatccaga acaatacaat agccgcctca     3060

agaacaaaat atggtatggt cttctgggaa gcaaggaatt actgcaacgc tcttacagga     3120

aattggaaga gcgaatacac ctcgagtgtg atggagaagc tgtctccttg ccaaaccttc     3180

aaggcatcgt agtgctcaac attacgagct acgctggagg cgtcaacttt tggggaagaa     3240

acagagcaac cacagaatat gatgtccctg caatcaatga tgggaagcta gaggttgtgg     3300

caatctttgg ttctgtgcag atggccatgt ctcgtatcgt caacctgcaa caacatcgaa     3360

ttgcgcagtg ccatgaggtg gtaataacta ttgatggtga agacggtgtc cctgtgcaag     3420

tggatgggga agcctggatt cagaagccag gccttatcaa gattaaatac aagaatgttg     3480

cccagatgtt gatgagagat agggactttg agaactcaat gaaaacctgg gaatctaagc     3540

atactgaaat ccaagctgtc caaccacccc acctggattt ccaggaatct caagacagcc     3600

tctctgatgg agagtatgcc cagatgcagc acttggctcg gcttgcagaa aacctcatta     3660

gcagacttac tgacctaagc aaggtccacc agcacgtgtc tgtcctcatg gattctgtga     3720

atgccagtgc taacatactg aatgatgtgt tctatagcca agacagtggt aacgaagcag     3780

gcgcagcttc ctgcattccc attgagactc taagcagaac tgatgcagta gatgttacat     3840

ttagtcttaa agggctctac gatgacacca aagctttcct ggatgaaaac ttgttgagag     3900

atgctgagga tcgggccatg ctacaaactg ccttggatgc catgaataca gagttaagaa     3960

ggatactggc aattggctgg ctgagtcaaa tcttctttcc agaggaacag gcttctgaca     4020

ctcgcagttt aagtcgtagg tttagaataa aattccccaa gctggggaag aagaaacaac     4080

gagaagaggg agaaaagcct aaatcaagcc aaagattccc tggttttctt ggcaagttct     4140

ggcgtcgaag aaatcgtagc aatcgagcaa aagctgatga ccctccaaca ccttcaagtt     4200

ctcaactata cccatacgat gttccagatt acgcttagtc cttgaaagct ggaaggagag     4260

ctctcaacac agaattctac taaaaactct caagacctca agaaaggctg aactaaatta     4320

tttctgaaca aacatgagca ccaccaagaa agaccctcca aatccttata ctaatatgtt     4380

ttccccagac ttaatcagat caccttagag ggttacattt ttctcgttgg ccaaagattc     4440

ttgttccgag ttgtcttgtt cagttcttct cgttgtgtac cttgggcaac tacagtgttt     4500

attggggaca ggctctctat gaatggcctg ggagctatga gaatgtatgg gagtgcatct     4560

cgttaggaaa tattagaatg gggggtcttt cacttggaga gaaactgttg acaccaagga     4620

ataaatgagt gaccaagtct cagaaagatg aggaagggga agggtgtcca ggcttagttg     4680

tgtttctcct ccaatccctg ccaattgcaa cttgaatttc aaaagatggc tcctagttgg     4740

cttaagaaga tgagaacaag gtcctggggc ttgtccactc atctgttaca atgactatgt     4800

gaatcttttc ttatagatat agaactctcc tcttctctct ttcctttctc ctctcatttc     4860

ctcttctctc ctctaccacc tcttatctcc tctacatctc ttctctctcc tctcacttct     4920

ctctttctcc acctccttct aatttctttc ccctttcttt cctttccatc tctccttctc     4980

ttccactttc ctctattact ccttatctcc ccataaactc ttcgtgtttt tccatgtgta     5040

catgtatgtc tttgcacatg tccaggtggt gctctcgtgg ctgggtgggc ccactggttg     5100

gaactcaccc ctcatggcaa ccatacaggc tcctgtactt ttgccttgat cccagcctgc     5160

atgtctccat ggagtgcttg cctgcattct cgctggattt tttaactaaa tgttttgccg     5220

ctgtgctgca gtatagatta tatacagaga cataaagatg tacatatata tacatatata     5280

tttttaagaa ctgaaaatac aactcgacct ctaagtgacc ctctaattta ttatgataac     5340

ccaggaatcc ctcctcatcc ctattaccct atacacatat atactctacc aactgcccta     5400

gttcttggtg gagcttctaa tcttttggtg cattttttag tgtcttagaa gtagctgggg     5460

tctatatatc ccagctaatt ctgacatcca cttctgagcc aggccacaga aggggaacaa     5520

aaacaccaat gccctgccaa aagggcccag ctggcatgct gccatttagc tctgtttctc     5580

ctggctctac atcagtaact gcccaagcta tatcaccctc ctccccaata aaaagatgtc     5640

aaagagctct accctttaaa tgtctaagtc agggtctacc tgacaataaa accacagccc     5700

atgcccctcc ccaaaagctt aatctgggcc tgcagctatt agataagctg ttgggtcact     5760

cctcaaatta tcttcaaatc tcatatctta ccccctcccc ccccccccag agtataagag     5820

aggcagtcag agtgaccaga aagaacattg atctgggaaa agaaaggcga aaagcctctg     5880

cttccccact gttctgcttc caaggtggtt ttcatgaaca tagtcggtct ccaatctcag     5940

tcaagtaaat ctgccgagag tgcagtgctc agaaagaagg tctctggtct acctcctctt     6000

caccctcaag tcgcaccttt tggaacaagt cccttcccac ttatcaagaa aaagatccag     6060

aaaactgccc ttttctcact gctcagccaa acttagcgtg ctcaattacc ttgctcagtc     6120

caatggctgg ttcactgagg tgcacaatcc agacttcgat cactggttct taactttcta     6180

gaacaccacc agcctaaccc acttaaacca gctgcctgtg ttccacctct tcaagggtga     6240

gaaaaagaga ctaacaatgg ggtagtcccc aaacatctga tagctgtgcc aaacaaaaaa     6300

acaaaaaaca aaaaaaaaat gtcctcgctc tacaactgga gaagaaattc aatgggaaaa     6360

gatgacagaa aacgtgtaag actcaaataa cagaatgtgt acgtgttgac agtgtatgta     6420

tttgagggga gtgctgttgc agtgtctctg gttttctctt atgcctcttt cttcccagga     6480

ggaggtatct gatcaaacca ccaaggttcc tccttggttg caggaatgaa tacctgcaca     6540

gacacactca cagagttggg atccatctta aattttctca gaggagtctt tcccaaggat     6600

catgtataaa taagcaaatt taaggaaaca gaaggaaatc ttaggaaacc gtagccttat     6660

cttggtagtg actaagcagg gctatgtctt gtaattattt ttatcacaat gatagtcaac     6720

tggaacagga ccccatctct gcctattttg ctgaagtact actgtaggtc tttgtgtact     6780

gcaatgctgc tgttgctcta ttgtaccatc tgaattccca ctcactttcc ctgttccccc     6840

acctgagtca gagtgctact gaatgacacc cataggatgg ggacttgaac caaatgtgga     6900

gcaaaactga taagctaaaa aaccaacttg gcttgttaaa atggtccaga tatcattagt     6960

taccgatttc ttttcctgag aaaggaagat gacatgctaa gaacgtgttc acacatctac     7020

aaagtaagaa gggatctccc tccctcccta gctacctacc atctccccct ctcctccctc     7080

tttctctctc ccccacctcc tctgaagtta acttagcccc taagaacatg ggctcctttc     7140

aagatttcat tgttgactat ttgaagaact acagttgttc aggtggtggg actggaaacc     7200

aagtatctgc cacagttatg tgcagaaatc attaagaatc aaaactctgg ggtttgattg     7260

tgtctttggt agtactttct gcagaattga ttgaatggct aattcttggc cagaaggaca     7320

ttagagaagg aaaaatctga atagcgttaa gctgccacca accacttctg gcattgatac     7380

tataggaggt caccagctat cctgtaaagc cctctgttac agcaaagaag gttaagagaa     7440

gaataaaaag taataaaagg tgaccagaag aaatttgggg ggatcaacat catcttccca     7500

caggacacag tagaatttta gttgtataac agatggaaac tattaccaaa gagatcagac     7560

ctcattcaca ctttcccatt ggatacggga ccttgattgg ctttatggtt atggagttgc     7620

attcgtctgc taatctgtaa tacattgttg ctttctattc tgtgttctgt gttttctcaa     7680

aggccctgca aaataagtag cagggccagg gcctggttag gggaggaggc tggaatagtc     7740

atggaataac agaaaaaaat gcagaaggaa aagatccaca aagtgtgcct attcctttta     7800

gccctcccca caaaatggaa caccagtcct cacaattgta attgcttctt aaaatatttt     7860

aataaatgga taaatagcat caatatctac gtcttctcac ttctttcaac ttggaggggg     7920

tgatagttaa atggggctgg atgttagtta ttggattggg gtggtctttt aagctctcaa     7980

taggctacca acaggtacca gaggcaggaa agactaggca gcaaaacaca aaccaggact     8040

ggcccatcat tgtgatttta atactacaag tgctgttgaa gctgg                     8085


<210>  9
<211>  1271
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Arg Gly Ala Ala Ala Ala Gln Gly Thr Ala Pro Pro Gln Asp 
1               5                   10                  15      


Gly Glu Gln Pro Ala Glu Ser Pro Glu Pro Pro Pro Pro Trp Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Ala Pro Pro Pro Ala Pro Pro Leu Leu Ser Glu 
        35                  40                  45              


Ala Ser Pro Glu Pro Ile Pro Glu Pro Cys Pro Glu Leu Ala Pro Gly 
    50                  55                  60                  


Pro Cys Pro Glu Ala Thr Ser Glu Ser Ala Thr Glu Leu Tyr Thr Glu 
65                  70                  75                  80  


Pro Thr Pro Glu Pro Ala Thr Glu Pro Ala Ser Glu Pro Ala Pro Glu 
                85                  90                  95      


Pro Ala Thr Glu Pro Ala Pro Glu Pro Ala Thr Glu Pro Ala Pro Glu 
            100                 105                 110         


Pro Ala Pro Glu Pro Ala Thr Glu Ser Ala Pro Glu Pro Thr Pro Glu 
        115                 120                 125             


Pro Ala Leu Glu Ser Val Pro Glu Pro Ala Pro Glu Leu Thr Pro Glu 
    130                 135                 140                 


Val Ala Pro Glu Leu Ala Pro Glu Pro Thr Pro Glu Pro Val Thr Glu 
145                 150                 155                 160 


Leu Ala Pro Glu Phe Cys Pro Glu Ala Ala Pro Glu Phe Arg Pro Ser 
                165                 170                 175     


Pro Ala Pro Cys Leu Leu Gln Cys Pro Val Asp Thr Arg Glu Arg Gly 
            180                 185                 190         


Leu Lys Thr Ser Pro Ser Pro Ser Pro Ser Pro Ser Pro Arg Thr Pro 
        195                 200                 205             


Met Ser Trp Ser Arg Ile Lys Lys Ile Leu Lys Glu Gly Pro Met Leu 
    210                 215                 220                 


Lys Asn Cys Asn Ser Phe Lys Arg Trp Lys Leu Arg Tyr Phe Leu Val 
225                 230                 235                 240 


Gln Gly Gln Lys Leu Tyr Phe Ala His His Pro Ala Phe Ala His Phe 
                245                 250                 255     


Glu Thr Ile Asp Leu Ser Gln Ala Thr Val Ala Glu Ser Ser Cys Arg 
            260                 265                 270         


Asn Leu Cys His Ser Phe Cys Val Ile Thr Pro Gln Arg Lys Ile Thr 
        275                 280                 285             


Leu Ala Ala Pro Asn Arg Lys Asp Met Glu Glu Trp Ile Asn Ile Ile 
    290                 295                 300                 


Lys Thr Ile Gln Gln Gly Glu Ile Tyr Lys Ile Pro Ala Ala Glu Asn 
305                 310                 315                 320 


Asn Pro Phe Leu Val Gly Met His Cys Trp Tyr Ser Ser Tyr Ser His 
                325                 330                 335     


Arg Thr Gln His Cys Asn Val Cys Arg Glu Ser Ile Pro Ala Leu Ser 
            340                 345                 350         


Arg Asp Ala Ile Ile Cys Glu Val Cys Lys Val Lys Ser His Arg Leu 
        355                 360                 365             


Cys Ala Leu Arg Ala Ser Lys Asp Cys Lys Trp Asn Thr Leu Ser Ile 
    370                 375                 380                 


Thr Asp Asp Leu Leu Leu Pro Ala Asp Glu Val Asn Met Pro His Gln 
385                 390                 395                 400 


Trp Val Glu Gly Asn Met Pro Val Ser Ser Gln Cys Ala Val Cys His 
                405                 410                 415     


Glu Ser Cys Gly Ser Tyr Gln Arg Leu Gln Asp Phe Arg Cys Leu Trp 
            420                 425                 430         


Cys Asn Ser Thr Val His Asp Asp Cys Arg Arg Arg Phe Ser Lys Glu 
        435                 440                 445             


Cys Cys Phe Arg Ser His Arg Ser Ser Val Ile Pro Pro Thr Ala Leu 
    450                 455                 460                 


Ser Asp Pro Lys Gly Asp Gly Gln Leu Val Val Ser Ser Asp Phe Trp 
465                 470                 475                 480 


Asn Leu Asp Trp Ser Ser Ala Cys Ser Cys Pro Leu Leu Ile Phe Ile 
                485                 490                 495     


Asn Ser Lys Ser Gly Asp His Gln Gly Ile Val Phe Leu Arg Lys Phe 
            500                 505                 510         


Lys Gln Tyr Leu Asn Pro Ser Gln Val Phe Asp Leu Leu Lys Gly Gly 
        515                 520                 525             


Pro Glu Ala Gly Leu Ser Met Phe Lys Asn Phe Ala Arg Phe Arg Ile 
    530                 535                 540                 


Leu Val Cys Gly Gly Asp Gly Ser Val Ser Trp Val Leu Ser Leu Ile 
545                 550                 555                 560 


Asp Ala Phe Gly Leu His Glu Lys Cys Gln Leu Ala Val Ile Pro Leu 
                565                 570                 575     


Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Ala Phe Trp 
            580                 585                 590         


Asn Lys Ser Lys Ser Pro Leu Asp Ile Leu Asn Arg Val Glu Gln Ala 
        595                 600                 605             


Ser Val Arg Ile Leu Asp Arg Trp Ser Val Met Ile Arg Glu Thr Pro 
    610                 615                 620                 


Arg Gln Thr Pro Leu Leu Lys Gly Gln Val Glu Met Asp Val Pro Arg 
625                 630                 635                 640 


Phe Glu Ala Ala Ala Ile Gln His Leu Glu Ser Ala Ala Thr Glu Leu 
                645                 650                 655     


Asn Lys Ile Leu Lys Ala Lys Tyr Pro Thr Glu Met Ile Ile Ala Thr 
            660                 665                 670         


Arg Phe Leu Cys Ser Ala Val Glu Asp Phe Val Val Asp Ile Val Lys 
        675                 680                 685             


Ala Trp Gly Gln Ile Lys Gln Asn Asn Thr Ala Ile Val Ser Val Ile 
    690                 695                 700                 


Leu Lys Ser Asp Leu Met Tyr Asp Arg Leu Ser Val Leu Ile Asp Val 
705                 710                 715                 720 


Leu Ala Glu Glu Ala Ala Ala Thr Ser Ala Glu Lys Ser Ala Thr Glu 
                725                 730                 735     


Tyr Ala Asp Ser Ser Lys Ala Asp Arg Lys Pro Phe Ile Pro Gln Ile 
            740                 745                 750         


Asp His Ile Ala Lys Cys Lys Leu Glu Leu Ala Thr Lys Ala Gln Ser 
        755                 760                 765             


Leu Gln Lys Ser Leu Lys Leu Ile Ile Phe Gln Val Glu Gln Ala Leu 
    770                 775                 780                 


Asp Glu Glu Ser Arg Gln Thr Ile Ser Val Lys Asn Phe Ser Ser Thr 
785                 790                 795                 800 


Phe Phe Leu Glu Asp Asp Pro Glu Asp Ile Asn Gln Thr Ser Pro Arg 
                805                 810                 815     


Arg Arg Ser Arg Arg Gly Thr Leu Ser Ser Ile Ser Ser Leu Lys Ser 
            820                 825                 830         


Glu Asp Leu Asp Asn Leu Asn Leu Asp His Leu His Phe Thr Pro Glu 
        835                 840                 845             


Ser Ile Arg Phe Lys Glu Lys Cys Val Met Asn Asn Tyr Phe Gly Ile 
    850                 855                 860                 


Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe Asn Thr Arg Arg Asp Glu 
865                 870                 875                 880 


His Pro Gly Gln Tyr Asn Ser Arg Leu Lys Asn Lys Met Trp Tyr Gly 
                885                 890                 895     


Leu Leu Gly Thr Lys Glu Leu Leu Gln Arg Ser Tyr Arg Lys Leu Glu 
            900                 905                 910         


Glu Arg Val His Leu Glu Cys Asp Gly Glu Thr Ile Ser Leu Pro Asn 
        915                 920                 925             


Leu Gln Gly Ile Val Val Leu Asn Ile Thr Ser Tyr Ala Gly Gly Ile 
    930                 935                 940                 


Asn Phe Trp Gly Ser Asn Thr Ala Thr Thr Glu Tyr Glu Ala Pro Ala 
945                 950                 955                 960 


Ile Asp Asp Gly Lys Leu Glu Val Val Ala Ile Phe Gly Ser Val Gln 
                965                 970                 975     


Met Ala Met Ser Arg Ile Ile Asn Leu His His His Arg Ile Ala Gln 
            980                 985                 990         


Cys His Glu Val Met Ile Thr Ile  Asp Gly Glu Glu Gly  Ile Pro Val 
        995                 1000                 1005             


Gln Val  Asp Gly Glu Ala Trp  Ile Gln Arg Pro Gly  Leu Ile Lys 
    1010                 1015                 1020             


Ile Arg  Tyr Lys Asn Ala Ala  Gln Met Leu Thr Arg  Asp Arg Asp 
    1025                 1030                 1035             


Phe Glu  Asn Ser Met Lys Met  Trp Glu Tyr Lys His  Thr Glu Ile 
    1040                 1045                 1050             


Gln Ala  Ala Pro Gln Pro Gln  Leu Asp Phe Gln Asp  Ser Gln Glu 
    1055                 1060                 1065             


Ser Leu  Ser Asp Glu Glu Tyr  Ala Gln Met Gln His  Leu Ala Arg 
    1070                 1075                 1080             


Leu Ala  Glu Asn Leu Ile Ser  Lys Leu Asn Asp Leu  Ser Lys Ile 
    1085                 1090                 1095             


His Gln  His Val Ser Val Leu  Met Gly Ser Val Asn  Ala Ser Ala 
    1100                 1105                 1110             


Asn Ile  Leu Asn Asp Ile Phe  Tyr Gly Gln Asp Ser  Gly Asn Glu 
    1115                 1120                 1125             


Met Gly  Ala Ala Ser Cys Ile  Pro Ile Glu Thr Leu  Ser Arg Asn 
    1130                 1135                 1140             


Asp Ala  Val Asp Val Thr Phe  Ser Leu Lys Gly Leu  Tyr Asp Asp 
    1145                 1150                 1155             


Thr Thr  Ala Phe Leu Asp Glu  Lys Leu Leu Arg Ser  Ala Glu Asp 
    1160                 1165                 1170             


Glu Thr  Ala Leu Gln Ser Ala  Leu Asp Ala Met Asn  Lys Glu Phe 
    1175                 1180                 1185             


Lys Lys  Leu Ser Glu Ile Asp  Trp Met Asn Pro Ile  Phe Val Pro 
    1190                 1195                 1200             


Glu Glu  Lys Ser Ser Asp Thr  Asp Ser Arg Ser Leu  Arg Leu Lys 
    1205                 1210                 1215             


Ile Lys  Phe Pro Lys Leu Gly  Lys Lys Lys Val Glu  Glu Glu Arg 
    1220                 1225                 1230             


Lys Pro  Lys Ser Gly Gln Ser  Val Gln Ser Phe Ile  Gly Asn Leu 
    1235                 1240                 1245             


Trp His  Arg Arg His Arg Glu  Asp Glu Ala Glu Gly  Asp Asp Pro 
    1250                 1255                 1260             


Leu Thr  Pro Ser Arg Ser Gln  Leu 
    1265                 1270     


