                         SEQUENCE LISTING

<110>  ProQR Therapeutics II BV
       van Diepen, Hester  C.
       Turunen, Janne J.
       Chan, Hee Lam
 
<120>  Antisense oligonucleotides for the treatment of eye disease

<130>  P3048PC00

<150>  GB 1616202.6
<151>  2016-09-23

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  670
<212>  DNA
<213>  Homo sapiens

<400>  1
taaatatatt ttatctttag ggcttaggtg tgatcattgc aattttggat ttaaatttct       60

ccgaagcttt aatgatgttg gatgtgagcc ctgccagtgt aacctccatg gctcagtgaa      120

caaattctgc aatcctcact ctgggcagtg tgagtgcaaa aaagaagcca aaggacttca      180

gtgtgacacc tgcagagaaa acttttatgg gttagatgtc accaattgta aggcctgtga      240

ctgtgacaca gctggatccc tccctgggac tgtctgtaat gctaagacag ggcagtgcat      300

ctgcaagccc aatgttgaag ggagacagtg caataaatgt ttggagggaa acttctacct      360

acggcaaaat aattctttcc tctgtctgcc ttgcaactgt gataagactg ggacaataaa      420

tggctctctg ctgtgtaaca aatcaacagg acaatgtcct tgcaaattag gggtaacagg      480

tcttcgctgt aatcagtgtg agcctcacag gtacaatttg accattgaca attttcaaca      540

ctgccagatg tgtgagtgtg attccttggg gacattacct gggaccattt gtgacccaat      600

cagtggccag tgcctgtgtg tgcctaatcg tcaaggaaga aggtgtaatc agtgtcaacc      660

aggtaagaaa                                                             670


<210>  2
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  2
ggcttaggtg tgatcattgc aattttggat ttaaatttct ccgaagcttt aatgatgttg       60

gatgtgagcc ctgccagtgt aacctccatg gctcagtgaa caaattctgc aatcctcact      120

ctgggcagtg tgagtgcaaa aaagaagcca aaggacttca gtgtgacacc tgcagagaaa      180

acttttatgg gttagatgtc accaattgta aggcctgtga ctgtgacaca gctggatccc      240

tccctgggac tgtctgtaat gctaagacag ggcagtgcat ctgcaagccc aatgttgaag      300

ggagacagtg caataaatgt ttggagggaa acttctacct acggcaaaat aattctttcc      360

tctgtctgcc ttgcaactgt gataagactg ggacaataaa tggctctctg ctgtgtaaca      420

aatcaacagg acaatgtcct tgcaaattag gggtaacagg tcttcgctgt aatcagtgtg      480

agcctcacag gtacaatttg accattgaca attttcaaca ctgccagatg tgtgagtgtg      540

attccttggg gacattacct gggaccattt gtgacccaat cagtggccag tgcctgtgtg      600

tgcctaatcg tcaaggaaga aggtgtaatc agtgtcaacc ag                         642


<210>  3
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic antisense oligonucleotide AON1

<400>  3
gagccaugga gguuacacug gcag                                              24


<210>  4
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide AON2

<400>  4
acacaggcac uggccacuga uu                                                22


<210>  5
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide Ex13-1

<400>  5
caccuaagcc cuaaagauaa aau                                               23


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide Ex13-2

<400>  6
ugaucacacc uaagcccuaa a                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide Ex13-3

<400>  7
agcuucggag aaauuuaaau c                                                 21


<210>  8
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide Ex13-4

<400>  8
ggcucacauc caacaucau                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antisense oligonucleotide Ex13-5

<400>  9
ucacacugcc cagagugag                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer exon 11

<400>  10
aagttggtgc agatccttcg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer exon 15

<400>  11
agaaacactg gcctgtgacc                                                   20


<210>  12
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  12
auuuuaucuu uagggcuuag gug                                               23


<210>  13
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  13
uuuagggcuu aggugugauc a                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  14
gauuuaaauu ucuccgaagc u                                                 21


<210>  15
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  15
augauguugg augugagcc                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  16
cucacucugg gcaguguga                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer ddPCR

<400>  17
tgggacagtg gatggagata                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer ddPCR

<400>  18
tggcattgcc tggagaaata                                                   20


<210>  19
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe ddPCR

<400>  19
attcaggcca gtgcaagtgc aaag                                              24


<210>  20
<211>  670
<212>  RNA
<213>  Homo sapiens

<400>  20
uaaauauauu uuaucuuuag ggcuuaggug ugaucauugc aauuuuggau uuaaauuucu       60

ccgaagcuuu aaugauguug gaugugagcc cugccagugu aaccuccaug gcucagugaa      120

caaauucugc aauccucacu cugggcagug ugagugcaaa aaagaagcca aaggacuuca      180

gugugacacc ugcagagaaa acuuuuaugg guuagauguc accaauugua aggccuguga      240

cugugacaca gcuggauccc ucccugggac ugucuguaau gcuaagacag ggcagugcau      300

cugcaagccc aauguugaag ggagacagug caauaaaugu uuggagggaa acuucuaccu      360

acggcaaaau aauucuuucc ucugucugcc uugcaacugu gauaagacug ggacaauaaa      420

uggcucucug cuguguaaca aaucaacagg acaauguccu ugcaaauuag ggguaacagg      480

ucuucgcugu aaucagugug agccucacag guacaauuug accauugaca auuuucaaca      540

cugccagaug ugugagugug auuccuuggg gacauuaccu gggaccauuu gugacccaau      600

caguggccag ugccugugug ugccuaaucg ucaaggaaga agguguaauc agugucaacc      660

agguaagaaa                                                             670


<210>  21
<211>  642
<212>  RNA
<213>  Homo sapiens

<400>  21
ggcuuaggug ugaucauugc aauuuuggau uuaaauuucu ccgaagcuuu aaugauguug       60

gaugugagcc cugccagugu aaccuccaug gcucagugaa caaauucugc aauccucacu      120

cugggcagug ugagugcaaa aaagaagcca aaggacuuca gugugacacc ugcagagaaa      180

acuuuuaugg guuagauguc accaauugua aggccuguga cugugacaca gcuggauccc      240

ucccugggac ugucuguaau gcuaagacag ggcagugcau cugcaagccc aauguugaag      300

ggagacagug caauaaaugu uuggagggaa acuucuaccu acggcaaaau aauucuuucc      360

ucugucugcc uugcaacugu gauaagacug ggacaauaaa uggcucucug cuguguaaca      420

aaucaacagg acaauguccu ugcaaauuag ggguaacagg ucuucgcugu aaucagugug      480

agccucacag guacaauuug accauugaca auuuucaaca cugccagaug ugugagugug      540

auuccuuggg gacauuaccu gggaccauuu gugacccaau caguggccag ugccugugug      600

ugccuaaucg ucaaggaaga agguguaauc agugucaacc ag                         642


<210>  22
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Control AON

<400>  22
ggauagguau gagauac                                                      17


<210>  23
<211>  18
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Control AON

<400>  23
ccucuuaccu caguuaca                                                     18


