                         SEQUENCE LISTING

<110>  Biomay AG
 
<120>  Polypeptide construct comprising fragments of allergens

<130>  48955

<150>  EP 16189774.9
<151>  2016-09-20

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  PRT
<213>  Ambrosia artemisiifolia

<400>  1

Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
1               5                   10                  15      


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Trp Arg Gly 
            20                  25                  30          


Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala Gln 
        35                  40                  45              


Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Gly Asp Val Tyr Thr 
    50                  55                  60                  


Val Thr Ser Asn Leu Asp Asp Asp Val Ala Asn Pro Lys Glu Gly Thr 
65                  70                  75                  80  


Leu Arg Phe Ala Ala Ala Gln Asn Arg Pro Leu Trp Ile Ile Phe Lys 
                85                  90                  95      


Asn Asp Met Val Ile Asn Leu Asn Gln Glu Leu Val Val Asn Ser Asp 
            100                 105                 110         


Lys Thr Ile Asp Gly Arg Gly Val Lys Val Glu Ile Ile Asn Gly Gly 
        115                 120                 125             


Leu Thr Leu Met Asn Val Lys Asn Ile Ile Ile His Asn Ile Asn Ile 
    130                 135                 140                 


His Asp Val Lys Val Leu Pro Gly Gly Met Ile Lys Ser Asn Asp Gly 
145                 150                 155                 160 


Pro Pro Ile Leu Arg Gln Ala Ser Asp Gly Asp Thr Ile Asn Val Ala 
                165                 170                 175     


Gly Ser Ser Gln Ile Trp Ile Asp His Cys Ser Leu Ser Lys Ser Phe 
            180                 185                 190         


Asp Gly Leu Val Asp Val Thr Leu Gly Ser Thr His Val Thr Ile Ser 
        195                 200                 205             


Asn Cys Lys Phe Thr Gln Gln Ser Lys Ala Ile Leu Leu Gly Ala Asp 
    210                 215                 220                 


Asp Thr His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn 
225                 230                 235                 240 


Met Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg Cys Arg Phe Gly 
                245                 250                 255     


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
            260                 265                 270         


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Gln Gly Asn Arg Phe 
        275                 280                 285             


Leu Ala Pro Asp Asp Gln Ile Lys Lys Asn Val Leu Ala Arg Thr Gly 
    290                 295                 300                 


Thr Gly Ala Ala Glu Ser Met Ala Trp Asn Trp Arg Ser Asp Lys Asp 
305                 310                 315                 320 


Leu Leu Glu Asn Gly Ala Ile Phe Val Thr Ser Gly Ser Asp Pro Val 
                325                 330                 335     


Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu 
            340                 345                 350         


Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Arg Pro 
        355                 360                 365             


Gly Ala Pro Cys 
    370         


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  2

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Xaa 
            20                  25              


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is cysteine or serine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  3

Ala Glu Asp Leu Gln Gln Ile Leu Pro Ser Ala Asn Glu Thr Arg Ser 
1               5                   10                  15      


Leu Thr Thr Xaa Gly Thr Tyr Asn Ile Ile Asp Gly Xaa 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is cysteine or serine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  4

Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
1               5                   10                  15      


Leu Gln Ala Xaa Glu Ala Tyr Asn Ile Ile Asp Lys Xaa 
            20                  25                  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is cysteine or serine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  5

Ala Glu Asp Val Glu Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg 
1               5                   10                  15      


Ser Leu Lys Ala Xaa Glu Ala His Asn Ile Ile Asp Lys Xaa 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is cysteine, serine, leucine or no amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is histidine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenylalanine or valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is arginine or lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is threonine or serine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is isoleucine or leucine

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is serine or alanine

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is glycine, serine or alanine

<400>  6

Xaa Arg Xaa Gly Phe Xaa Gln Val Val Asn Asn Asn Tyr Xaa Xaa Trp 
1               5                   10                  15      


Gly Xaa Tyr Ala Xaa Gly Gly Ser Xaa Xaa Pro Thr Ile Leu 
            20                  25                  30  


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is serine or valine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is valine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is serine, lysine or asparagine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is alanine or serine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is valine or alanine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is leucine or isoleucine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is serine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  7

Xaa Asp Pro Val Leu Thr Pro Xaa Gln Xaa Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Xaa Xaa Xaa Xaa Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Xaa 
        


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is cysteine, leucine, serine or no amino acid residue

<400>  8

Xaa Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu 
            20                  25                  30  


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is cysteine, leucine, serine or no amino acid residue

<400>  9

Xaa Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
            20                  25                  30  


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  10

Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Xaa 
        


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is cysteine, serine or no amino acid residue

<400>  11

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Xaa 
        


<210>  12
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1

<400>  12

Pro Leu Trp Ile Ile Phe Glu Arg Asp Met Val Ile Arg Leu Asp Lys 
1               5                   10                  15      


Glu Met Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly 
            20                  25                  30  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  13

Pro Leu Trp Ile Ile Phe Ala Arg Asp Met Val Ile Arg Leu Asp Arg 
1               5                   10                  15      


Glu Leu Ala Ile Asn Asn Asp Lys Thr Ile Asp Gly Arg Gly 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  14

Pro Leu Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln 
1               5                   10                  15      


Glu Leu Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly 
            20                  25                  30  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  15

Pro Leu Trp Ile Ile Phe Lys Arg Asn Met Val Ile His Leu Asn Gln 
1               5                   10                  15      


Glu Leu Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly 
            20                  25                  30  


<210>  16
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  16

Ala Lys Val Glu Ile Ile Asn Ala Gly Phe Thr Leu Asn Gly Val Lys 
1               5                   10                  15      


Asn Val Ile Ile His Asn Ile Asn Met His Asp Val Lys Val Asn Pro 
            20                  25                  30          


Gly 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  17

Ala Lys Val Glu Ile Ile Asn Ala Gly Phe Ala Ile Tyr Asn Val Lys 
1               5                   10                  15      


Asn Ile Ile Ile His Asn Ile Ile Met His Asp Ile Val Val Asn Pro 
            20                  25                  30          


Gly 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  18

Val Lys Val Glu Ile Ile Asn Gly Gly Leu Thr Leu Met Asn Val Lys 
1               5                   10                  15      


Asn Ile Ile Ile His Asn Ile Asn Ile His Asp Val Lys Val Leu Pro 
            20                  25                  30          


Gly 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  19

Val Lys Val Asn Ile Val Asn Ala Gly Leu Thr Leu Met Asn Val Lys 
1               5                   10                  15      


Asn Ile Ile Ile His Asn Ile Asn Ile His Asp Ile Lys Val Cys Pro 
            20                  25                  30          


Gly 
    


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  20

Ala Gly Asp Glu Asn Ile Glu Asp Arg Gly Met Leu Ala Thr Val Ala 
1               5                   10                  15      


Phe Asn Thr Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg 
            20                  25                  30  


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  21

Asp Phe Asp Glu Arg Gly Met Leu Cys Thr Val Ala Phe Asn Lys Phe 
1               5                   10                  15      


Thr Asp Asn Val Asp Gln Arg Met Pro Asn 
            20                  25      


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  22

Ala Asp Asp Thr His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala 
1               5                   10                  15      


Phe Asn Met Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  23

Ala Asp Asp Thr His Tyr Gln Asp Lys Gly Met Leu Ala Thr Val Ala 
1               5                   10                  15      


Phe Asn Met Phe Thr Asp His Val Asp Gln Arg Met Pro Arg 
            20                  25                  30  


<210>  24
<211>  173
<212>  PRT
<213>  Hepatitis B virus

<400>  24

Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
1               5                   10                  15      


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            20                  25                  30          


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
        35                  40                  45              


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
    50                  55                  60                  


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
65                  70                  75                  80  


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
                85                  90                  95      


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
            100                 105                 110         


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
        115                 120                 125             


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
    130                 135                 140                 


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
145                 150                 155                 160 


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn 
                165                 170             


<210>  25
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4His

<400>  25

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val 
    50                  55                  60                  


Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys 
65                  70                  75                  80  


Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile 
                85                  90                  95      


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr 
            100                 105                 110         


Asn Ile Ile Asp Lys Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val 
145                 150                 155                 160 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
                405                 410                 415     


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu 
    450                 455                 460                 


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Lys Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    530                 535                 540                 


Leu His His His His His His 
545                 550     


<210>  26
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4AHis

<400>  26

Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly 
1               5                   10                  15      


Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Arg Phe Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val Gly Glu 
    50                  55                  60                  


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala 
65                  70                  75                  80  


Tyr Asn Ile Ile Asp Lys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
                85                  90                  95      


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
            100                 105                 110         


Asp Lys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        115                 120                 125             


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    130                 135                 140                 


Val Leu Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met 
145                 150                 155                 160 


Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala 
                165                 170                 175     


Gly Val Leu Ser Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
            180                 185                 190         


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
        195                 200                 205             


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
    210                 215                 220                 


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
225                 230                 235                 240 


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
                245                 250                 255     


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
            260                 265                 270         


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
        275                 280                 285             


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
    290                 295                 300                 


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
305                 310                 315                 320 


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
                325                 330                 335     


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
            340                 345                 350         


Asn Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro 
        355                 360                 365             


Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val 
    370                 375                 380                 


Leu Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
385                 390                 395                 400 


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
                405                 410                 415     


Val Leu Ser Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu 
            420                 425                 430         


Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Ala 
        435                 440                 445             


Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu 
    450                 455                 460                 


Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Arg Phe Gly Phe Phe 
465                 470                 475                 480 


Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly 
                485                 490                 495     


Gly Ser Ser Ala Pro Thr Ile Leu Arg Phe Gly Phe Phe Gln Val Val 
            500                 505                 510         


Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser 
        515                 520                 525             


Ala Pro Thr Ile Leu His His His His His His 
    530                 535                 


<210>  27
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4BHis

<400>  27

Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val 
    50                  55                  60                  


Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser 
65                  70                  75                  80  


Glu Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile 
                85                  90                  95      


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr 
            100                 105                 110         


Asn Ile Ile Asp Lys Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val 
145                 150                 155                 160 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
                405                 410                 415     


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile Leu 
    450                 455                 460                 


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Lys Ser Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    530                 535                 540                 


Leu His His His His His His 
545                 550     


<210>  28
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4Cvar

<400>  28

Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly 
        115                 120                 125             


Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser 
    130                 135                 140                 


Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
145                 150                 155                 160 


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
                165                 170                 175     


Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys Pro Arg 
            180                 185                 190         


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
        195                 200                 205             


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
    210                 215                 220                 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
225                 230                 235                 240 


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
                245                 250                 255     


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
            260                 265                 270         


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
        275                 280                 285             


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
    290                 295                 300                 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
305                 310                 315                 320 


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
                325                 330                 335     


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
            340                 345                 350         


Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala 
        355                 360                 365             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser 
    370                 375                 380                 


Ser Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln 
385                 390                 395                 400 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu 
                405                 410                 415     


Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Asp Leu Gln Glu Ile 
            420                 425                 430         


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
        435                 440                 445             


Ile Ile Asp Gly Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Ser Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys 
                485                 490                 495     


Trp Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser 
            500                 505                 510         


Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly 
        515                 520                 525             


Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu 
    530                 535                 540     


<210>  29
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4Dvar

<400>  29

Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly 
        115                 120                 125             


Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser 
    130                 135                 140                 


Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
145                 150                 155                 160 


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
                165                 170                 175     


Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys Pro Arg 
            180                 185                 190         


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
        195                 200                 205             


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
    210                 215                 220                 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
225                 230                 235                 240 


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
                245                 250                 255     


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
            260                 265                 270         


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
        275                 280                 285             


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
    290                 295                 300                 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
305                 310                 315                 320 


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
                325                 330                 335     


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
            340                 345                 350         


Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala 
        355                 360                 365             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser 
    370                 375                 380                 


Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val Gln 
385                 390                 395                 400 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
                405                 410                 415     


Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Gly Val Gly Glu Ile 
            420                 425                 430         


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr 
        435                 440                 445             


Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Ser Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
                485                 490                 495     


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
            500                 505                 510         


Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg 
        515                 520                 525             


Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
    530                 535                 540             


<210>  30
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4Evar

<400>  30

Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Ser Ala Glu Gly Val Gly Glu Ile Leu 
                85                  90                  95      


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn 
            100                 105                 110         


Ile Ile Asp Lys Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala 
        115                 120                 125             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser 
    130                 135                 140                 


Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val Gln 
145                 150                 155                 160 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
                165                 170                 175     


Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys Pro 
            180                 185                 190         


Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 
        195                 200                 205             


Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn 
    210                 215                 220                 


Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn 
225                 230                 235                 240 


Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly 
                245                 250                 255     


Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val 
            260                 265                 270         


Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln 
        275                 280                 285             


Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met 
    290                 295                 300                 


Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val 
305                 310                 315                 320 


Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn 
                325                 330                 335     


Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr 
            340                 345                 350         


Gly Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
        355                 360                 365             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
    370                 375                 380                 


Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val 
385                 390                 395                 400 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                405                 410                 415     


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Asp Leu Gln Glu 
            420                 425                 430         


Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr 
        435                 440                 445             


Asn Ile Ile Asp Gly Ser Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Ser Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
                485                 490                 495     


Asp Lys Trp Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile 
            500                 505                 510         


Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg 
        515                 520                 525             


Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
    530                 535                 540             


<210>  31
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4F

<400>  31

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ser Asp Pro Val 
    50                  55                  60                  


Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu 
65                  70                  75                  80  


Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp 
                85                  90                  95      


Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro 
            100                 105                 110         


Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys 
        115                 120                 125             


Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
    130                 135                 140                 


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly 
145                 150                 155                 160 


Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala 
                165                 170                 175     


Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ala Glu Gly Val Gly Glu Ile Leu Pro 
        355                 360                 365             


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile 
    370                 375                 380                 


Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn 
385                 390                 395                 400 


Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys 
                405                 410                 415     


Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro 
            420                 425                 430         


Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val 
        435                 440                 445             


Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met 
    450                 455                 460                 


Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala 
465                 470                 475                 480 


Gly Val Leu Ser Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  32
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4G

<400>  32

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        35                  40                  45              


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    50                  55                  60                  


Val Leu Ser Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn 
65                  70                  75                  80  


Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys 
                85                  90                  95      


Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg 
            100                 105                 110         


Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Cys Arg 
        115                 120                 125             


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
    130                 135                 140                 


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly 
145                 150                 155                 160 


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
                165                 170                 175     


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Cys Arg Phe Gly Phe Phe Gln Val Val 
        355                 360                 365             


Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser 
    370                 375                 380                 


Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
385                 390                 395                 400 


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
                405                 410                 415     


Thr Ile Leu Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu 
            420                 425                 430         


Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
        435                 440                 445             


Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
    450                 455                 460                 


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ser Asp Pro 
465                 470                 475                 480 


Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly 
                485                 490                 495     


Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser 
            500                 505                 510         


Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu 
        515                 520                 525             


Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser 
    530                 535                 540                 


Cys 
545 


<210>  33
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4H

<400>  33

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        35                  40                  45              


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    50                  55                  60                  


Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly 
65                  70                  75                  80  


Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser 
                85                  90                  95      


Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser 
            100                 105                 110         


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr 
        115                 120                 125             


Ser Ser Ala Gly Val Leu Ser Cys Cys Arg Phe Gly Phe Phe Gln Val 
    130                 135                 140                 


Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser 
145                 150                 155                 160 


Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn 
                165                 170                 175     


Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala 
            180                 185                 190         


Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn 
        195                 200                 205             


Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr 
    210                 215                 220                 


Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp 
225                 230                 235                 240 


Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
                245                 250                 255     


Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
            260                 265                 270         


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
        275                 280                 285             


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
    290                 295                 300                 


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
                325                 330                 335     


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
            340                 345                 350         


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
        355                 360                 365             


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
    370                 375                 380                 


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
385                 390                 395                 400 


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
                405                 410                 415     


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn Ala Glu Gly 
            420                 425                 430         


Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala 
        435                 440                 445             


Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu 
    450                 455                 460                 


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala 
465                 470                 475                 480 


Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro 
                485                 490                 495     


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile 
            500                 505                 510         


Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn 
        515                 520                 525             


Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys 
    530                 535                 540                 


Cys 
545 


<210>  34
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4I

<400>  34

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        35                  40                  45              


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    50                  55                  60                  


Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly 
65                  70                  75                  80  


Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser 
                85                  90                  95      


Ala Gly Val Leu Ser Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn 
            100                 105                 110         


Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala 
        115                 120                 125             


Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn 
    130                 135                 140                 


Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr 
145                 150                 155                 160 


Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp 
                165                 170                 175     


Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
            180                 185                 190         


Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
        195                 200                 205             


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
    210                 215                 220                 


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
225                 230                 235                 240 


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
                245                 250                 255     


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
            260                 265                 270         


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
        275                 280                 285             


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
    290                 295                 300                 


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
305                 310                 315                 320 


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
                325                 330                 335     


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
            340                 345                 350         


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn Ala Glu Gly 
        355                 360                 365             


Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala 
    370                 375                 380                 


Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu 
385                 390                 395                 400 


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala 
                405                 410                 415     


Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro 
            420                 425                 430         


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile 
        435                 440                 445             


Ile Asp Lys Cys 
    450         


<210>  35
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4J

<400>  35

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        35                  40                  45              


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    50                  55                  60                  


Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly 
65                  70                  75                  80  


Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser 
                85                  90                  95      


Ala Gly Val Leu Ser Ser Ser Arg Phe Gly Phe Phe Gln Val Val Asn 
            100                 105                 110         


Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala 
        115                 120                 125             


Pro Thr Ile Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn 
    130                 135                 140                 


Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr 
145                 150                 155                 160 


Ile Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp 
                165                 170                 175     


Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
            180                 185                 190         


Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
        195                 200                 205             


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
    210                 215                 220                 


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
225                 230                 235                 240 


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
                245                 250                 255     


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
            260                 265                 270         


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
        275                 280                 285             


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
    290                 295                 300                 


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
305                 310                 315                 320 


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
                325                 330                 335     


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
            340                 345                 350         


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn Ala Glu Gly 
        355                 360                 365             


Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala 
    370                 375                 380                 


Ser Glu Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu 
385                 390                 395                 400 


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala 
                405                 410                 415     


Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile Leu Pro 
            420                 425                 430         


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn Ile 
        435                 440                 445             


Ile Asp Lys Ser 
    450         


<210>  36
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4CHis

<400>  36

Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly 
        115                 120                 125             


Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser 
    130                 135                 140                 


Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
145                 150                 155                 160 


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
                165                 170                 175     


Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg 
            180                 185                 190         


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
        195                 200                 205             


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
    210                 215                 220                 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
225                 230                 235                 240 


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
                245                 250                 255     


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
            260                 265                 270         


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
        275                 280                 285             


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
    290                 295                 300                 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
305                 310                 315                 320 


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
                325                 330                 335     


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
            340                 345                 350         


Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala 
        355                 360                 365             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser 
    370                 375                 380                 


Ser Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln 
385                 390                 395                 400 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu 
                405                 410                 415     


Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Asp Leu Gln Glu Ile 
            420                 425                 430         


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
        435                 440                 445             


Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Cys Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys 
                485                 490                 495     


Trp Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys 
            500                 505                 510         


Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly 
        515                 520                 525             


Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu His His His 
    530                 535                 540                 


His His His 
545         


<210>  37
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4K

<400>  37

Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr Glu Arg Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile Leu Leu Arg 
            20                  25                  30          


His Gly Phe Val Gln Val Val Asn Asn Asn Tyr Glu Arg Trp Gly Ser 
        35                  40                  45              


Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Gln Ile Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Cys 
65                  70                  75                  80  


Gly Thr Tyr Asn Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Gln Ile 
                85                  90                  95      


Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Cys Gly Thr Tyr 
            100                 105                 110         


Asn Ile Ile Asp Gly Cys Val Asp Pro Val Leu Thr Pro Glu Gln Asn 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu 
145                 150                 155                 160 


Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln 
        355                 360                 365             


Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Glu Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
                405                 410                 415     


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Asp Leu Gln 
            420                 425                 430         


Gln Ile Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Cys Gly 
        435                 440                 445             


Thr Tyr Asn Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Gln Ile Leu 
    450                 455                 460                 


Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Cys Gly Thr Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Gly Cys Leu Arg His Gly Phe Val Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro 
            500                 505                 510         


Thr Ile Leu Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  38
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4L

<400>  38

Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr Glu Arg Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile Leu Leu Arg 
            20                  25                  30          


His Gly Phe Val Gln Val Val Asn Asn Asn Tyr Glu Arg Trp Gly Ser 
        35                  40                  45              


Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Gln Ile Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Ser 
65                  70                  75                  80  


Gly Thr Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Leu Gln Gln Ile 
                85                  90                  95      


Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Ser Gly Thr Tyr 
            100                 105                 110         


Asn Ile Ile Asp Gly Ser Val Asp Pro Val Leu Thr Pro Glu Gln Asn 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu 
145                 150                 155                 160 


Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln 
        355                 360                 365             


Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Glu Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
                405                 410                 415     


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Asp Leu Gln 
            420                 425                 430         


Gln Ile Leu Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Ser Gly 
        435                 440                 445             


Thr Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Leu Gln Gln Ile Leu 
    450                 455                 460                 


Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Ser Gly Thr Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Gly Ser Leu Arg His Gly Phe Val Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro 
            500                 505                 510         


Thr Ile Leu Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  39
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4M

<400>  39

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Val 
    50                  55                  60                  


Glu Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala 
65                  70                  75                  80  


Cys Glu Ala His Asn Ile Ile Asp Lys Cys Ala Glu Asp Val Glu Glu 
                85                  90                  95      


Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Cys Glu 
            100                 105                 110         


Ala His Asn Ile Ile Asp Lys Cys Ser Asp Pro Val Leu Thr Pro Glu 
        115                 120                 125             


Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
    130                 135                 140                 


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr 
145                 150                 155                 160 


Pro Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val 
                165                 170                 175     


Leu Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser 
            180                 185                 190         


Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro 
        195                 200                 205             


Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn 
    210                 215                 220                 


Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro 
225                 230                 235                 240 


Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro 
                245                 250                 255     


Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 
            260                 265                 270         


Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser 
        275                 280                 285             


Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro 
    290                 295                 300                 


Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp 
305                 310                 315                 320 


Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly 
                325                 330                 335     


Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser 
            340                 345                 350         


Ala Arg Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro 
        355                 360                 365             


Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
    370                 375                 380                 


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu 
385                 390                 395                 400 


Thr Pro Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala 
                405                 410                 415     


Val Leu Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Asp 
            420                 425                 430         


Val Glu Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys 
        435                 440                 445             


Ala Cys Glu Ala His Asn Ile Ile Asp Lys Cys Ala Glu Asp Val Glu 
    450                 455                 460                 


Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Cys 
465                 470                 475                 480 


Glu Ala His Asn Ile Ile Asp Lys Cys Cys Arg Phe Gly Phe Phe Gln 
                485                 490                 495     


Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly 
            500                 505                 510         


Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val 
        515                 520                 525             


Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser 
    530                 535                 540                 


Ala Pro Thr Ile Leu 
545                 


<210>  40
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4N

<400>  40

Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Val 
    50                  55                  60                  


Glu Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala 
65                  70                  75                  80  


Ser Glu Ala His Asn Ile Ile Asp Lys Ser Ala Glu Asp Val Glu Glu 
                85                  90                  95      


Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Cys Glu 
            100                 105                 110         


Ala His Asn Ile Ile Asp Lys Ser Ser Asp Pro Val Leu Thr Pro Glu 
        115                 120                 125             


Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
    130                 135                 140                 


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr 
145                 150                 155                 160 


Pro Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val 
                165                 170                 175     


Leu Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser 
            180                 185                 190         


Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro 
        195                 200                 205             


Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn 
    210                 215                 220                 


Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro 
225                 230                 235                 240 


Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro 
                245                 250                 255     


Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu 
            260                 265                 270         


Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser 
        275                 280                 285             


Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro 
    290                 295                 300                 


Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp 
305                 310                 315                 320 


Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly 
                325                 330                 335     


Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser 
            340                 345                 350         


Ala Arg Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro 
        355                 360                 365             


Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
    370                 375                 380                 


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu 
385                 390                 395                 400 


Thr Pro Glu Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala 
                405                 410                 415     


Val Leu Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Asp 
            420                 425                 430         


Val Glu Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys 
        435                 440                 445             


Ala Ser Glu Ala His Asn Ile Ile Asp Lys Ser Ala Glu Asp Val Glu 
    450                 455                 460                 


Glu Phe Leu Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Ser 
465                 470                 475                 480 


Glu Ala His Asn Ile Ile Asp Lys Ser Ser Arg Phe Gly Phe Phe Gln 
                485                 490                 495     


Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly 
            500                 505                 510         


Ser Ser Ala Pro Thr Ile Leu Ser Arg Phe Gly Phe Phe Gln Val Val 
        515                 520                 525             


Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser 
    530                 535                 540                 


Ala Pro Thr Ile Leu 
545                 


<210>  41
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4O

<400>  41

Pro Leu Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln 
1               5                   10                  15      


Glu Leu Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Pro Leu 
            20                  25                  30          


Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln Glu Leu 
        35                  40                  45              


Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Pro Leu Trp Ile 
    50                  55                  60                  


Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln Glu Leu Val Val 
65                  70                  75                  80  


Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Ser Asp Pro Val Leu Thr 
                85                  90                  95      


Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala 
            100                 105                 110         


Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val 
        115                 120                 125             


Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu 
    130                 135                 140                 


Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp 
145                 150                 155                 160 


Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro 
                165                 170                 175     


Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys 
            180                 185                 190         


Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
        195                 200                 205             


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
    210                 215                 220                 


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
225                 230                 235                 240 


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
                245                 250                 255     


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
            260                 265                 270         


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
        275                 280                 285             


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
    290                 295                 300                 


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
305                 310                 315                 320 


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
                325                 330                 335     


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
            340                 345                 350         


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Cys Arg Phe Gly 
        355                 360                 365             


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
    370                 375                 380                 


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe 
385                 390                 395                 400 


Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly 
                405                 410                 415     


Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val 
            420                 425                 430         


Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser 
        435                 440                 445             


Ser Ala Pro Thr Ile Leu Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu 
                485                 490                 495     


Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
            500                 505                 510         


Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
        515                 520                 525             


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
    530                 535                 540     


<210>  42
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4P

<400>  42

Pro Leu Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln 
1               5                   10                  15      


Glu Leu Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Pro Leu 
            20                  25                  30          


Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln Glu Leu 
        35                  40                  45              


Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Pro Leu Trp Ile 
    50                  55                  60                  


Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln Glu Leu Val Val 
65                  70                  75                  80  


Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Cys Arg Phe Gly Phe Phe 
                85                  90                  95      


Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly 
            100                 105                 110         


Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val 
        115                 120                 125             


Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser 
    130                 135                 140                 


Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn 
145                 150                 155                 160 


Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala 
                165                 170                 175     


Pro Thr Ile Leu Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
            180                 185                 190         


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
        195                 200                 205             


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
    210                 215                 220                 


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
225                 230                 235                 240 


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
                245                 250                 255     


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
            260                 265                 270         


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
        275                 280                 285             


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
    290                 295                 300                 


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
305                 310                 315                 320 


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
                325                 330                 335     


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
            340                 345                 350         


Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
        355                 360                 365             


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
    370                 375                 380                 


Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
385                 390                 395                 400 


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
                405                 410                 415     


Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly 
            420                 425                 430         


Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser 
        435                 440                 445             


Ala Gly Val Leu Ser Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu 
                485                 490                 495     


Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
            500                 505                 510         


Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
        515                 520                 525             


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
    530                 535                 540     


<210>  43
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4Q

<400>  43

Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Val Glu Glu Phe Leu 
                85                  90                  95      


Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Cys Glu Ala His 
            100                 105                 110         


Asn Ile Ile Asp Lys Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Glu 
145                 150                 155                 160 


Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Glu Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
                405                 410                 415     


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Asp Leu Gln Gln Ile Leu 
    450                 455                 460                 


Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Cys Gly Thr Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Gly Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  44
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4R

<400>  44

Ser Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Ser Ala Glu Asp Val Glu Glu Phe Leu 
                85                  90                  95      


Pro Ser Ala Asn Glu Thr Arg Arg Ser Leu Lys Ala Cys Glu Ala His 
            100                 105                 110         


Asn Ile Ile Asp Lys Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Glu 
145                 150                 155                 160 


Gln Lys Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu Arg 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Ser Val Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Glu Gln Asn Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Val Leu 
                405                 410                 415     


Arg Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Asp Leu Gln Gln Ile Leu 
    450                 455                 460                 


Pro Ser Ala Asn Glu Thr Arg Ser Leu Thr Thr Ser Gly Thr Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Gly Ser Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Leu Arg His Gly Phe Val Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Glu Arg Trp Gly Ser Tyr Ala Leu Gly Gly Ser Ala Gly Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  45

Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser 
1               5                   10                  15      


Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys 
            20                  25                  


<210>  46
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  46

Trp Arg Gly Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp 
1               5                   10                  15      


Cys Ala Gln Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Cys 
            20                  25                  30      


<210>  47
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  47

Gly Asp Val Tyr Thr Val Thr Ser Asn Leu Asp Asp Asp Val Ala Asn 
1               5                   10                  15      


Pro Lys Glu Gly Thr Leu Arg Phe Ala Ala Ala Gln Asn Arg Cys 
            20                  25                  30      


<210>  48
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  48

Pro Leu Trp Ile Ile Phe Lys Asn Asp Met Val Ile Asn Leu Asn Gln 
1               5                   10                  15      


Glu Leu Val Val Asn Ser Asp Lys Thr Ile Asp Gly Arg Gly Cys 
            20                  25                  30      


<210>  49
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  49

Val Lys Val Glu Ile Ile Asn Gly Gly Leu Thr Leu Met Asn Val Lys 
1               5                   10                  15      


Asn Ile Ile Ile His Asn Ile Asn Ile His Asp Val Lys Val Leu Pro 
            20                  25                  30          


Gly Cys 
        


<210>  50
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  50

Gly Met Ile Lys Ser Asn Asp Gly Pro Pro Ile Leu Arg Gln Ala Ser 
1               5                   10                  15      


Asp Gly Asp Thr Ile Asn Val Ala Gly Ser Ser Gln Ile Trp Ile Asp 
            20                  25                  30          


His Cys 
        


<210>  51
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  51

Cys Phe Asp Gly Leu Val Asp Val Thr Leu Gly Ser Thr His Val Thr 
1               5                   10                  15      


Ile Ser Asn Cys Lys Phe Thr Gln Gln Ser Lys Ala Ile Leu Leu Gly 
            20                  25                  30          


<210>  52
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  52

Cys Ala Asp Asp Thr His Val Gln Asp Lys Gly Met Leu Ala Thr Val 
1               5                   10                  15      


Ala Phe Asn Met Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg 
            20                  25                  30      


<210>  53
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  53

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
            20                  25                  30  


<210>  54
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  54

Cys Gln Gly Asn Arg Phe Leu Ala Pro Asp Asp Gln Ile Lys Lys Asn 
1               5                   10                  15      


Val Leu Ala Arg Thr Gly Thr Gly Ala Ala Glu Ser Met Ala Trp Asn 
            20                  25                  30          


Trp Arg Ser 
        35  


<210>  55
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amb a 1 fragment

<400>  55

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Cys 
        


<210>  56
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K1

<400>  56

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly 
    50                  55                  60                  


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
65                  70                  75                  80  


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly Phe Phe 
                85                  90                  95      


Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly 
            100                 105                 110         


Gly Ser Ser Ala Pro Thr Ile Leu Gly Gly Trp Ser Ser Lys Pro Arg 
        115                 120                 125             


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
    130                 135                 140                 


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
145                 150                 155                 160 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
                165                 170                 175     


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
            180                 185                 190         


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
        195                 200                 205             


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
    210                 215                 220                 


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
225                 230                 235                 240 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
                245                 250                 255     


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
            260                 265                 270         


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
        275                 280                 285             


Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala 
    290                 295                 300                 


Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser 
305                 310                 315                 320 


Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln 
                325                 330                 335     


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
            340                 345                 350         


Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro 
        355                 360                 365             


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
    370                 375                 380                 


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu 
385                 390                 395                 400 


Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala 
                405                 410                 415     


Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys 
            420                 425                 


<210>  57
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2

<400>  57

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg Phe Gly 
    50                  55                  60                  


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
65                  70                  75                  80  


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Gly Gly Trp Ser Ser Lys 
                85                  90                  95      


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
            100                 105                 110         


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
        115                 120                 125             


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
    130                 135                 140                 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
145                 150                 155                 160 


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
                165                 170                 175     


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
            180                 185                 190         


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
        195                 200                 205             


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
    210                 215                 220                 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
225                 230                 235                 240 


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
                245                 250                 255     


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
            260                 265                 270         


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
        275                 280                 285             


Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro 
    290                 295                 300                 


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
305                 310                 315                 320 


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu 
                325                 330                 335     


Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala 
            340                 345                 350         


Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys 
        355                 360                 365 


<210>  58
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K3

<400>  58

Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala 
1               5                   10                  15      


Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu 
            20                  25                  30          


Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        35                  40                  45              


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    50                  55                  60                  


Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly 
65                  70                  75                  80  


Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser 
                85                  90                  95      


Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly 
            100                 105                 110         


Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp 
        115                 120                 125             


His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp 
    130                 135                 140                 


Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly 
145                 150                 155                 160 


Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu 
                165                 170                 175     


Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile 
            180                 185                 190         


Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro 
        195                 200                 205             


Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn 
    210                 215                 220                 


Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu 
225                 230                 235                 240 


Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro 
                245                 250                 255     


Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro 
            260                 265                 270         


Val Thr Asn Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        275                 280                 285             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    290                 295                 300                 


Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg 
305                 310                 315                 320 


Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys 
                325                 330                 335     


Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly 
            340                 345                 350         


Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
        355                 360                 365 


<210>  59
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4

<400>  59

Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val 
    50                  55                  60                  


Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys 
65                  70                  75                  80  


Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile 
                85                  90                  95      


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr 
            100                 105                 110         


Asn Ile Ile Asp Lys Cys Ser Asp Pro Val Leu Thr Pro Val Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val 
145                 150                 155                 160 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
                405                 410                 415     


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu 
    450                 455                 460                 


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Lys Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  60
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K5

<400>  60

Trp Arg Gly Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp 
1               5                   10                  15      


Cys Ala Gln Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Trp Arg 
            20                  25                  30          


Gly Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala 
        35                  40                  45              


Gln Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Ala Asp Asp Thr 
    50                  55                  60                  


His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn Met Phe 
65                  70                  75                  80  


Thr Asp Asn Val Asp Gln Arg Met Pro Arg Ala Asp Asp Thr His Val 
                85                  90                  95      


Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn Met Phe Thr Asp 
            100                 105                 110         


Asn Val Asp Gln Arg Met Pro Arg Ala Glu Gly Val Gly Glu Ile Leu 
        115                 120                 125             


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn 
    130                 135                 140                 


Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val 
145                 150                 155                 160 


Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp 
                165                 170                 175     


Lys Cys Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn 
            180                 185                 190         


Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp 
        195                 200                 205             


Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro 
    210                 215                 220                 


Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe 
225                 230                 235                 240 


Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro 
                245                 250                 255     


Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala 
            260                 265                 270         


Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro 
        275                 280                 285             


Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe 
    290                 295                 300                 


His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala 
305                 310                 315                 320 


Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser 
                325                 330                 335     


His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn Trp 
            340                 345                 350         


Arg Gly Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys 
        355                 360                 365             


Ala Gln Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Trp Arg Gly 
    370                 375                 380                 


Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala Gln 
385                 390                 395                 400 


Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Ala Asp Asp Thr His 
                405                 410                 415     


Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn Met Phe Thr 
            420                 425                 430         


Asp Asn Val Asp Gln Arg Met Pro Arg Ala Asp Asp Thr His Val Gln 
        435                 440                 445             


Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn Met Phe Thr Asp Asn 
    450                 455                 460                 


Val Asp Gln Arg Met Pro Arg Ala Glu Gly Val Gly Glu Ile Leu Pro 
465                 470                 475                 480 


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile 
                485                 490                 495     


Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn 
            500                 505                 510         


Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys 
        515                 520                 525             


Cys 
    


<210>  61
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K6

<400>  61

Ala Asp Asp Thr His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala 
1               5                   10                  15      


Phe Asn Met Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg Ala Asp 
            20                  25                  30          


Asp Thr His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn 
        35                  40                  45              


Met Phe Thr Asp Asn Val Asp Gln Arg Met Pro Arg Ala Asp Asp Thr 
    50                  55                  60                  


His Val Gln Asp Lys Gly Met Leu Ala Thr Val Ala Phe Asn Met Phe 
65                  70                  75                  80  


Thr Asp Asn Val Asp Gln Arg Met Pro Arg Ser Asp Pro Val Leu Thr 
                85                  90                  95      


Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala 
            100                 105                 110         


Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val 
        115                 120                 125             


Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu 
    130                 135                 140                 


Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ser Asp 
145                 150                 155                 160 


Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro 
                165                 170                 175     


Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Cys 
            180                 185                 190         


Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser 
        195                 200                 205             


Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
    210                 215                 220                 


Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys 
225                 230                 235                 240 


Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly Ala Phe Gly Pro 
                245                 250                 255     


Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala 
            260                 265                 270         


Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro Pro Ala Ser Thr 
        275                 280                 285             


Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg 
    290                 295                 300                 


Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr Ala Phe His Gln 
305                 310                 315                 320 


Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
                325                 330                 335     


Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile Ala Ser His Ile 
            340                 345                 350         


Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr Asn Ala Glu Gly 
        355                 360                 365             


Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala 
    370                 375                 380                 


Cys Glu Ala Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu 
385                 390                 395                 400 


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala 
                405                 410                 415     


Tyr Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro 
            420                 425                 430         


Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile 
        435                 440                 445             


Ile Asp Lys Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn 
    450                 455                 460                 


Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr 
465                 470                 475                 480 


Ile Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp 
                485                 490                 495     


Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
            500                 505                 510         


Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
        515                 520                 525             


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Trp Arg 
    530                 535                 540                 


Gly Lys Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala 
545                 550                 555                 560 


Gln Gly Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Trp Arg Gly Lys 
                565                 570                 575     


Ala Asp Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala Gln Gly 
            580                 585                 590         


Phe Ala Lys Gly Thr Tyr Gly Gly Lys Trp Trp Arg Gly Lys Ala Asp 
        595                 600                 605             


Trp Glu Asn Asn Arg Gln Ala Leu Ala Asp Cys Ala Gln Gly Phe Ala 
    610                 615                 620                 


Lys Gly Thr Tyr Gly Gly Lys Trp 
625                 630         


<210>  62
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4A

<400>  62

Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly 
1               5                   10                  15      


Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Arg Phe Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val Gly Glu 
    50                  55                  60                  


Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala 
65                  70                  75                  80  


Tyr Asn Ile Ile Asp Lys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
                85                  90                  95      


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
            100                 105                 110         


Asp Lys Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
        115                 120                 125             


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
    130                 135                 140                 


Val Leu Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met 
145                 150                 155                 160 


Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala 
                165                 170                 175     


Gly Val Leu Ser Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
            180                 185                 190         


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
        195                 200                 205             


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
    210                 215                 220                 


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
225                 230                 235                 240 


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
                245                 250                 255     


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
            260                 265                 270         


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
        275                 280                 285             


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
    290                 295                 300                 


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
305                 310                 315                 320 


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
                325                 330                 335     


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
            340                 345                 350         


Asn Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile Pro 
        355                 360                 365             


Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly Val 
    370                 375                 380                 


Leu Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala Gly Met Ile 
385                 390                 395                 400 


Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser Ser Ala Gly 
                405                 410                 415     


Val Leu Ser Ala Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu 
            420                 425                 430         


Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Ala 
        435                 440                 445             


Glu Gly Val Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu 
    450                 455                 460                 


Gln Ala Cys Glu Ala Tyr Asn Ile Ile Asp Lys Arg Phe Gly Phe Phe 
465                 470                 475                 480 


Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly 
                485                 490                 495     


Gly Ser Ser Ala Pro Thr Ile Leu Arg Phe Gly Phe Phe Gln Val Val 
            500                 505                 510         


Asn Asn Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser 
        515                 520                 525             


Ala Pro Thr Ile Leu 
    530             


<210>  63
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4B

<400>  63

Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp 
1               5                   10                  15      


Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ser Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Gly Val 
    50                  55                  60                  


Gly Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser 
65                  70                  75                  80  


Glu Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile 
                85                  90                  95      


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr 
            100                 105                 110         


Asn Ile Ile Asp Lys Ser Ser Asp Pro Val Leu Thr Pro Val Gln Ser 
        115                 120                 125             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr 
    130                 135                 140                 


Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro Val 
145                 150                 155                 160 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                165                 170                 175     


Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Gly Gly Trp Ser Ser Lys 
            180                 185                 190         


Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly 
        195                 200                 205             


Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn 
    210                 215                 220                 


Asn Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala 
225                 230                 235                 240 


Asn Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His 
                245                 250                 255     


Gly Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg 
        275                 280                 285             


Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala 
    290                 295                 300                 


Met Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg 
305                 310                 315                 320 


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
                325                 330                 335     


Asn Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg 
            340                 345                 350         


Thr Gly Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln 
        355                 360                 365             


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
    370                 375                 380                 


Thr Ser Ser Ala Gly Val Leu Ser Ser Ser Asp Pro Val Leu Thr Pro 
385                 390                 395                 400 


Val Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile 
                405                 410                 415     


Lys Leu Thr Ser Ser Ala Gly Val Leu Ser Ser Ala Glu Gly Val Gly 
            420                 425                 430         


Glu Ile Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu 
        435                 440                 445             


Ala Tyr Asn Ile Ile Asp Lys Ser Ala Glu Gly Val Gly Glu Ile Leu 
    450                 455                 460                 


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Ser Glu Ala Tyr Asn 
465                 470                 475                 480 


Ile Ile Asp Lys Ser Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn 
                485                 490                 495     


Asn Tyr Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro 
            500                 505                 510         


Thr Ile Leu Ser Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
        515                 520                 525             


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
    530                 535                 540                 


Leu 
545 


<210>  64
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4C

<400>  64

Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly 
        115                 120                 125             


Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser 
    130                 135                 140                 


Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
145                 150                 155                 160 


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
                165                 170                 175     


Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg 
            180                 185                 190         


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
        195                 200                 205             


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
    210                 215                 220                 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
225                 230                 235                 240 


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
                245                 250                 255     


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
            260                 265                 270         


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
        275                 280                 285             


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
    290                 295                 300                 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
305                 310                 315                 320 


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
                325                 330                 335     


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
            340                 345                 350         


Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala 
        355                 360                 365             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser 
    370                 375                 380                 


Ser Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln 
385                 390                 395                 400 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu 
                405                 410                 415     


Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Asp Leu Gln Glu Ile 
            420                 425                 430         


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
        435                 440                 445             


Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Cys Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys 
                485                 490                 495     


Trp Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys 
            500                 505                 510         


Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly 
        515                 520                 525             


Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu 
    530                 535                 540     


<210>  65
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4D

<400>  65

Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly 
        115                 120                 125             


Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser 
    130                 135                 140                 


Ala Gly Val Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
145                 150                 155                 160 


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
                165                 170                 175     


Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg 
            180                 185                 190         


Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe 
        195                 200                 205             


Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro 
    210                 215                 220                 


Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln 
225                 230                 235                 240 


Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly 
                245                 250                 255     


Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser 
            260                 265                 270         


Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro 
        275                 280                 285             


Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln 
    290                 295                 300                 


Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg 
305                 310                 315                 320 


Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro 
                325                 330                 335     


Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly 
            340                 345                 350         


Asp Pro Val Thr Asn Ser Asp Pro Val Leu Thr Pro Val Gln Ser Ala 
        355                 360                 365             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu Thr Ser 
    370                 375                 380                 


Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln 
385                 390                 395                 400 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
                405                 410                 415     


Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Gly Val Gly Glu Ile 
            420                 425                 430         


Leu Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr 
        435                 440                 445             


Asn Ile Ile Asp Lys Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Cys Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
                485                 490                 495     


Asp Arg Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile 
            500                 505                 510         


Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg 
        515                 520                 525             


Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
    530                 535                 540             


<210>  66
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4E

<400>  66

Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp 
1               5                   10                  15      


Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg 
            20                  25                  30          


Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg Trp Gly Thr 
        35                  40                  45              


Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu Ala Glu Asp Leu 
    50                  55                  60                  


Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly 
65                  70                  75                  80  


Ala Tyr Asn Ile Ile Asp Gly Cys Ala Glu Gly Val Gly Glu Ile Leu 
                85                  90                  95      


Pro Ser Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn 
            100                 105                 110         


Ile Ile Asp Lys Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala 
        115                 120                 125             


Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser 
    130                 135                 140                 


Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val Gln 
145                 150                 155                 160 


Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys Leu 
                165                 170                 175     


Thr Ser Ser Ala Gly Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro 
            180                 185                 190         


Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe 
        195                 200                 205             


Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn 
    210                 215                 220                 


Pro Asp Trp Asp Phe Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn 
225                 230                 235                 240 


Gln Val Gly Val Gly Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly 
                245                 250                 255     


Gly Ile Leu Gly Trp Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val 
            260                 265                 270         


Ser Thr Ile Pro Pro Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln 
        275                 280                 285             


Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met 
    290                 295                 300                 


Gln Trp Asn Ser Thr Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val 
305                 310                 315                 320 


Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn 
                325                 330                 335     


Pro Ala Pro Asn Ile Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr 
            340                 345                 350         


Gly Asp Pro Val Thr Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser 
        355                 360                 365             


Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr 
    370                 375                 380                 


Ser Ser Ala Gly Val Leu Ser Cys Ser Asp Pro Val Leu Thr Pro Val 
385                 390                 395                 400 


Gln Ser Ala Gly Met Ile Pro Ala Glu Pro Gly Glu Ala Ala Ile Lys 
                405                 410                 415     


Leu Thr Ser Ser Ala Gly Val Leu Ser Cys Ala Glu Asp Leu Gln Glu 
            420                 425                 430         


Ile Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr 
        435                 440                 445             


Asn Ile Ile Asp Gly Cys Ala Glu Gly Val Gly Glu Ile Leu Pro Ser 
    450                 455                 460                 


Val Asn Glu Thr Arg Ser Leu Gln Ala Cys Glu Ala Tyr Asn Ile Ile 
465                 470                 475                 480 


Asp Lys Cys Cys Arg His Gly Phe Phe Gln Val Val Asn Asn Asn Tyr 
                485                 490                 495     


Asp Lys Trp Gly Ser Tyr Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile 
            500                 505                 510         


Leu Cys Arg Phe Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Arg 
        515                 520                 525             


Trp Gly Thr Tyr Ala Ile Gly Gly Ser Ser Ala Pro Thr Ile Leu 
    530                 535                 540             


<210>  67
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4S

<400>  67

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys Cys Arg His Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg His Gly Phe Phe 
    50                  55                  60                  


Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile Gly 
65                  70                  75                  80  


Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu 
        115                 120                 125             


Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys 
    130                 135                 140                 


Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala 
145                 150                 155                 160 


Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu 
                165                 170                 175     


Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile 
            180                 185                 190         


Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly 
        195                 200                 205             


Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
    210                 215                 220                 


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
225                 230                 235                 240 


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
                245                 250                 255     


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
            260                 265                 270         


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
        275                 280                 285             


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
    290                 295                 300                 


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
305                 310                 315                 320 


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
                325                 330                 335     


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
            340                 345                 350         


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
        355                 360                 365             


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
    370                 375                 380                 


Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro 
385                 390                 395                 400 


Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val 
                405                 410                 415     


Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met 
            420                 425                 430         


Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala 
        435                 440                 445             


Gly Val Leu Ser Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg 
                485                 490                 495     


Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys Cys Arg His 
            500                 505                 510         


Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr 
        515                 520                 525             


Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg His Gly Phe 
    530                 535                 540                 


Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile 
545                 550                 555                 560 


Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile 
                565                 570                 575     


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
            580                 585                 590         


Ile Ile Asp Gly Cys 
        595         


<210>  68
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4SHis

<400>  68

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys Cys Arg His Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg His Gly Phe Phe 
    50                  55                  60                  


Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile Gly 
65                  70                  75                  80  


Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu 
        115                 120                 125             


Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys 
    130                 135                 140                 


Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala 
145                 150                 155                 160 


Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu 
                165                 170                 175     


Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile 
            180                 185                 190         


Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly 
        195                 200                 205             


Val Leu Ser Cys Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
    210                 215                 220                 


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
225                 230                 235                 240 


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
                245                 250                 255     


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
            260                 265                 270         


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
        275                 280                 285             


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
    290                 295                 300                 


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
305                 310                 315                 320 


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
                325                 330                 335     


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
            340                 345                 350         


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
        355                 360                 365             


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
    370                 375                 380                 


Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro 
385                 390                 395                 400 


Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val 
                405                 410                 415     


Leu Ser Cys Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met 
            420                 425                 430         


Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala 
        435                 440                 445             


Gly Val Leu Ser Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Cys Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg 
                485                 490                 495     


Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Cys Cys Arg His 
            500                 505                 510         


Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr 
        515                 520                 525             


Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Cys Arg His Gly Phe 
    530                 535                 540                 


Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile 
545                 550                 555                 560 


Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile 
                565                 570                 575     


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
            580                 585                 590         


Ile Ile Asp Gly Cys His His His His His His 
        595                 600             


<210>  69
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4T

<400>  69

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser Ser Arg His Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg His Gly Phe Phe 
    50                  55                  60                  


Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile Gly 
65                  70                  75                  80  


Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu 
        115                 120                 125             


Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser 
    130                 135                 140                 


Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala 
145                 150                 155                 160 


Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu 
                165                 170                 175     


Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile 
            180                 185                 190         


Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly 
        195                 200                 205             


Val Leu Ser Ser Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
    210                 215                 220                 


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
225                 230                 235                 240 


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
                245                 250                 255     


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
            260                 265                 270         


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
        275                 280                 285             


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
    290                 295                 300                 


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
305                 310                 315                 320 


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
                325                 330                 335     


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
            340                 345                 350         


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
        355                 360                 365             


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
    370                 375                 380                 


Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro 
385                 390                 395                 400 


Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val 
                405                 410                 415     


Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met 
            420                 425                 430         


Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala 
        435                 440                 445             


Gly Val Leu Ser Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg 
                485                 490                 495     


Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser Ser Arg His 
            500                 505                 510         


Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr 
        515                 520                 525             


Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg His Gly Phe 
    530                 535                 540                 


Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile 
545                 550                 555                 560 


Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile 
                565                 570                 575     


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
            580                 585                 590         


Ile Ile Asp Gly Ser 
        595         


<210>  70
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4THis

<400>  70

Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg Leu 
1               5                   10                  15      


Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser Ser Arg His Gly 
            20                  25                  30          


Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala 
        35                  40                  45              


Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg His Gly Phe Phe 
    50                  55                  60                  


Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile Gly 
65                  70                  75                  80  


Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile Leu 
                85                  90                  95      


Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile 
            100                 105                 110         


Ile Asp Gly Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu 
        115                 120                 125             


Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser 
    130                 135                 140                 


Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro Ala 
145                 150                 155                 160 


Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val Leu 
                165                 170                 175     


Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile 
            180                 185                 190         


Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly 
        195                 200                 205             


Val Leu Ser Ser Gly Gly Trp Ser Ser Lys Pro Arg Lys Gly Met Gly 
    210                 215                 220                 


Thr Asn Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
225                 230                 235                 240 


Leu Asp Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe 
                245                 250                 255     


Asn Pro Ile Lys Asp His Trp Pro Ala Ala Asn Gln Val Gly Val Gly 
            260                 265                 270         


Ala Phe Gly Pro Gly Leu Thr Pro Pro His Gly Gly Ile Leu Gly Trp 
        275                 280                 285             


Ser Pro Gln Ala Gln Gly Ile Leu Thr Thr Val Ser Thr Ile Pro Pro 
    290                 295                 300                 


Pro Ala Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser 
305                 310                 315                 320 


Pro Pro Leu Arg Asp Ser His Pro Gln Ala Met Gln Trp Asn Ser Thr 
                325                 330                 335     


Ala Phe His Gln Ala Leu Gln Asp Pro Arg Val Arg Gly Leu Tyr Phe 
            340                 345                 350         


Pro Ala Gly Gly Ser Ser Ser Gly Thr Val Asn Pro Ala Pro Asn Ile 
        355                 360                 365             


Ala Ser His Ile Ser Ser Ile Ser Ala Arg Thr Gly Asp Pro Val Thr 
    370                 375                 380                 


Asn Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met Ile Pro 
385                 390                 395                 400 


Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala Gly Val 
                405                 410                 415     


Leu Ser Ser Val Asp Pro Val Leu Thr Pro Glu Gln Ser Ala Gly Met 
            420                 425                 430         


Ile Pro Ala Glu Pro Gly Glu Ser Ala Leu Ser Leu Thr Ser Ser Ala 
        435                 440                 445             


Gly Val Leu Ser Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn 
    450                 455                 460                 


Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly 
465                 470                 475                 480 


Ser Ala Glu Asp Leu Gln Glu Ile Leu Pro Val Asn Glu Thr Arg Arg 
                485                 490                 495     


Leu Thr Thr Ser Gly Ala Tyr Asn Ile Ile Asp Gly Ser Ser Arg His 
            500                 505                 510         


Gly Phe Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr 
        515                 520                 525             


Ala Ile Gly Gly Ser Ala Ser Pro Thr Ile Leu Ser Arg His Gly Phe 
    530                 535                 540                 


Phe Gln Val Val Asn Asn Asn Tyr Asp Lys Trp Gly Ser Tyr Ala Ile 
545                 550                 555                 560 


Gly Gly Ser Ala Ser Pro Thr Ile Leu Ala Glu Asp Leu Gln Glu Ile 
                565                 570                 575     


Leu Pro Val Asn Glu Thr Arg Arg Leu Thr Thr Ser Gly Ala Tyr Asn 
            580                 585                 590         


Ile Ile Asp Gly Ser His His His His His His 
        595                 600             


