               SEQUENCE LISTING

<110> Molecular Partners AG

<120> Recombinant Binding Proteins

<130> P015

<160> 33

<170> BiSSAP 1.3

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> His-tag

<400> 1
Met Arg Gly Ser His His His His His His 
1               5                   10  

<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> GlySer linker

<400> 2
Gly Gly Gly Gly Ser 
1               5   

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> GlySer linker

<400> 3
Gly Gly Gly Gly Ser Gly Ser 
1               5           

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> GlySer linker

<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> GlySer linker

<400> 5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> GlySer linker

<400> 6
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> ProThr linker

<400> 7
Gly Ser Pro Thr Pro Thr Pro Thr 
1               5               

<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> ProThr linker

<400> 8
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
1               5                   10                  15  

<210> 9
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> ProThr linker

<400> 9
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro Thr 
            20          

<210> 10
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 10
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Thr Asp Asn Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Ser Asn Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Ser Asp Leu Thr Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Tyr Asp Asn Asp Gly His Thr Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 
Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 11
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 11
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 12
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 12
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 13
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 13
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 14
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 14
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 15
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 15
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 16
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 16
Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala Ala Lys Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala Ala Gln Ser Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 17
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 17
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Gly 
            100                 105                 110         
Ala Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 18
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 18
Gly Ser Asp Leu Gly Val Lys Leu Leu Trp Ala Ala Ala Arg Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Phe Gln Gly Ile Thr Pro Leu His Ile Ala Ala Thr Asn Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Ile Thr Gly Glu Thr Pro Leu His His Ala Ala Asp Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ala Gly Val Thr Pro Ala Asp Leu Ala Ala Ala 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 19
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 19
Gly Ser Asp Leu Gly Val Lys Leu Leu Trp Ala Ala Ala Arg Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Phe Gln Gly Ile Thr Pro Leu His Ile Ala Ala Gln Ser Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His 
65                  70                  75                  80  
Gly His Leu Val Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 20
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 20
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly 
            100                 105                 110         
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 21
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 21
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala 
145                 150                 155                 160 
Ala Lys Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala 
            180                 185                 190         
Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Asp Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro 
                325                 330                 335     
Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
465                 470                 475                 480 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
            500                 505                 510         
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 22
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 22
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala 
145                 150                 155                 160 
Ala Lys Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala 
            180                 185                 190         
Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Asp Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro 
                325                 330                 335     
Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
465                 470                 475                 480 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
            500                 505                 510         
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 23
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 23
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Val Lys Leu Leu Trp Ala Ala 
145                 150                 155                 160 
Ala Arg Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Phe Gln Gly Ile Thr Pro Leu His Ile Ala 
            180                 185                 190         
Ala Thr Asn Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Ile Thr Gly Glu Thr Pro Leu His His 
    210                 215                 220                 
Ala Ala Asp Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Lys Ala Gly Val Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Ala Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro 
                325                 330                 335     
Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
465                 470                 475                 480 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
            500                 505                 510         
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 24
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 24
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Ile Lys Leu 
    290                 295                 300                 
Leu Phe Ala Ala Ala Lys Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Val Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Thr Gly Asp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Glu Arg Gly Trp 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr 
465                 470                 475                 480 
Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala 
            500                 505                 510         
Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu 
        515                 520                 525             
Ile Ala Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 25
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 25
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Val Lys Leu 
    290                 295                 300                 
Leu Trp Ala Ala Ala Arg Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Ile Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Thr Asn Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ile Thr Gly Glu Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Asp Ser Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ala Gly Val 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Ala Trp Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr 
465                 470                 475                 480 
Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala 
            500                 505                 510         
Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu 
        515                 520                 525             
Ile Ala Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 26
<211> 562
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 26
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Ala Lys Leu Leu Ser Asp Leu Gly Val 
145                 150                 155                 160 
Lys Leu Leu Trp Ala Ala Ala Arg Gly Gln Asp Asp Glu Val Arg Ile 
                165                 170                 175     
Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Ile 
            180                 185                 190         
Thr Pro Leu His Ile Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu 
        195                 200                 205             
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Thr Gly 
    210                 215                 220                 
Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Val Ile Val 
225                 230                 235                 240 
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Glu Arg 
                245                 250                 255     
Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly His Glu Asp Ile 
            260                 265                 270         
Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
    290                 295                 300                 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
305                 310                 315                 320 
Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala 
                325                 330                 335     
His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
385                 390                 395                 400 
Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
                405                 410                 415     
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         
Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
        435                 440                 445             
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
    450                 455                 460                 
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
465                 470                 475                 480 
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
                485                 490                 495     
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
            500                 505                 510         
Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His 
        515                 520                 525             
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
    530                 535                 540                 
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
545                 550                 555                 560 
Ala Ala 
        

<210> 27
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 27
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Ala Lys Leu Leu Ser Asp Leu 
145                 150                 155                 160 
Gly Val Lys Leu Leu Trp Ala Ala Ala Arg Gly Gln Asp Asp Glu Val 
                165                 170                 175     
Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
            180                 185                 190         
Gly Ile Thr Pro Leu His Ile Ala Ala Gln Ser Gly His Leu Glu Ile 
        195                 200                 205             
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
    210                 215                 220                 
Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Val 
225                 230                 235                 240 
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
                245                 250                 255     
Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly His Glu 
            260                 265                 270         
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr 
        275                 280                 285             
Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
    290                 295                 300                 
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
305                 310                 315                 320 
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
                325                 330                 335     
Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly 
            340                 345                 350         
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        355                 360                 365             
Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
    370                 375                 380                 
Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val 
385                 390                 395                 400 
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly 
                405                 410                 415     
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser 
            420                 425                 430         
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
        435                 440                 445             
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
    450                 455                 460                 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
465                 470                 475                 480 
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
                485                 490                 495     
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            500                 505                 510         
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
        515                 520                 525             
Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His 
    530                 535                 540                 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
545                 550                 555                 560 
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
                565                 570                 575     
Ala Ala 
        

<210> 28
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 28
Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala Ala Lys Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala Ala Gln Ser Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala 
            180                 185                 190         
Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Gly Gly Ser Gly Gly Gly Ser Cys 
        275                 280             

<210> 29
<211> 414
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 29
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Arg Ser Asp Leu Gly Ala Lys Leu Leu Ser Asp Leu Gly Val Lys 
145                 150                 155                 160 
Leu Leu Trp Ala Ala Ala Arg Gly Gln Asp Asp Glu Val Arg Ile Leu 
                165                 170                 175     
Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Ile Thr 
            180                 185                 190         
Pro Leu His Ile Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu Val 
        195                 200                 205             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Thr Gly Asp 
    210                 215                 220                 
Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Val Ile Val Glu 
225                 230                 235                 240 
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Glu Arg Gly 
                245                 250                 255     
Trp Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly His Glu Asp Ile Ala 
            260                 265                 270         
Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
    290                 295                 300                 
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
305                 310                 315                 320 
Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly 
                325                 330                 335     
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
        355                 360                 365             
Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly 
385                 390                 395                 400 
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                405                 410                 

<210> 30
<211> 562
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 30
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Ser Asp Leu Gly Ala Lys Leu Leu Ser Asp Leu 
    290                 295                 300                 
Gly Val Lys Leu Leu Trp Ala Ala Ala Arg Gly Gln Asp Asp Glu Val 
305                 310                 315                 320 
Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
                325                 330                 335     
Gly Ile Thr Pro Leu His Ile Ala Ala Gln Ser Gly His Leu Glu Ile 
            340                 345                 350         
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
        355                 360                 365             
Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Val 
    370                 375                 380                 
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
385                 390                 395                 400 
Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly His Glu 
                405                 410                 415     
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly 
            420                 425                 430         
Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
        435                 440                 445             
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
    450                 455                 460                 
Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala 
465                 470                 475                 480 
Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly 
                485                 490                 495     
Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu 
            500                 505                 510         
Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His 
        515                 520                 525             
Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp 
    530                 535                 540                 
Ile Ser Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
545                 550                 555                 560 
Ala Ala 
        

<210> 31
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 31
Met Arg Gly Ser His His His His His His Gly Ser Asp Leu Gly Lys 
1               5                   10                  15      
Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu 
            20                  25                  30          
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His 
        35                  40                  45              
Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu 
    50                  55                  60                  
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly 
65                  70                  75                  80  
Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val 
                85                  90                  95      
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe 
            100                 105                 110         
Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile 
        115                 120                 125             
Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
    130                 135                 140                 
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
145                 150                 155                 160 
Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala Ala Lys Gly Gln Asp Asp 
                165                 170                 175     
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            180                 185                 190         
Phe Gln Gly Val Thr Pro Leu His Ile Ala Ala Gln Ser Gly His Leu 
        195                 200                 205             
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    210                 215                 220                 
Asp Val Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His 
225                 230                 235                 240 
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                245                 250                 255     
Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp Trp Gly 
            260                 265                 270         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        275                 280                 285             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    290                 295                 300                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
305                 310                 315                 320 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                325                 330                 335     
Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala 
            340                 345                 350         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        355                 360                 365             
Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala 
    370                 375                 380                 
Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys Ala Gly Ala 
385                 390                 395                 400 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                405                 410                 415     
Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            420                 425                 430         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        435                 440                 445             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    450                 455                 460                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala 
465                 470                 475                 480 
Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His 
                485                 490                 495     
Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            500                 505                 510         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu 
        515                 520                 525             
His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu 
    530                 535                 540                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro 
545                 550                 555                 560 
Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                565                 570                 575     
Gln Lys Ala Ala 
            580 

<210> 32
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 32
Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala Ala Lys Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala Ala Gln Ser Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu Ala Ala Gln His 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala 
            180                 185                 190         
Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala 
        

<210> 33
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 33
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Ile Lys Leu Leu Phe Ala Ala 
145                 150                 155                 160 
Ala Lys Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Phe Gln Gly Val Thr Pro Leu His Ile Ala 
            180                 185                 190         
Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Thr Gly Asp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Glu Arg Gly Trp Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Asp Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro 
                325                 330                 335     
Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Gly Ala Gly Asn Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala 
            420         

