                         SEQUENCE LISTING

<110>  Aarhus Universitet
 
<120>  Compounds for treatment of lipoprotein metabolism disorders

<130>  P4324PC00

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  692
<212>  PRT
<213>  Homo sapiens


<220>
<221>  BINDING
<222>  (78)..(167)
<223>  HSPG binding site

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  R93

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  R96

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  R97

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  R104

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  R105

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  K136

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  H139

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  R165

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  R167

<400>  1

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  2
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequences obtained by sequencing of the variable regions of the 
       immunoglobulin genes expressed by rat hybridomas 
       BNT-8H4-B8/C7-E11, BNT-5E11-D4/G1-E4


<220>
<221>  CDS
<222>  (1)..(318)
<223>  BNT-8H4-B8/C7-E11_VK

<220>
<221>  V_region
<222>  (1)..(69)

<220>
<221>  V_segment
<222>  (70)..(102)
<223>  CDR1

<220>
<221>  V_region
<222>  (103)..(147)

<220>
<221>  V_segment
<222>  (148)..(168)
<223>  CDR2

<220>
<221>  V_region
<222>  (169)..(264)

<220>
<221>  V_segment
<222>  (265)..(288)
<223>  CDR3

<220>
<221>  J_segment
<222>  (289)..(318)

<400>  2
gat att gtg atg acc cag tct ccc tca ctc ctg tct gca tct gtg gga         48
Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc act ctt agc tgc aaa gga agt cag aat att aac aat tac         96
Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr           
            20                  25                  30                    

tta gcc tgg tac caa caa aag ctc gga gaa gct ccc aaa ctc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat aat aca aac agt tta caa acg ggc atc cca tca agg ttc agt ggc        192
Tyr Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggt aca gat tgc aca ctc acc atc aga agc ctg cag cct        240
Ser Gly Ser Gly Thr Asp Cys Thr Leu Thr Ile Arg Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat gtt gcc aca tat ttc tgc tat cag tat aac aac ggg aac acg        288
Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Asn Asn Gly Asn Thr           
                85                  90                  95                

ttt gga ggt ggg acc aag ctg gag ctg aaa                                318
Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys                                   
            100                 105                                       


<210>  3
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  3

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Cys Thr Leu Thr Ile Arg Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Asn Asn Gly Asn Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  4
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequences obtained by sequencing of the variable regions of the 
       immunoglobulin genes expressed by rat hybridomas 
       BNT-8H4-B8/C7-E11, BNT-5E11-D4/G1-E4


<220>
<221>  CDS
<222>  (1)..(336)
<223>  BNT-5E11-D4/G1-E4_VK

<220>
<221>  V_region
<222>  (1)..(69)
<223>  FWR1

<220>
<221>  V_segment
<222>  (70)..(117)
<223>  CDR1

<220>
<221>  V_region
<222>  (118)..(162)
<223>  FWR2

<220>
<221>  V_segment
<222>  (163)..(183)
<223>  CDR2

<220>
<221>  V_region
<222>  (184)..(279)
<223>  FWR3

<220>
<221>  V_segment
<222>  (280)..(306)
<223>  CDR3

<220>
<221>  J_segment
<222>  (307)..(336)
<223>  JK

<400>  4
gat gtt gtg ttg aca caa act cca gtt ttc ctg tct gtc aca ctt gga         48
Asp Val Val Leu Thr Gln Thr Pro Val Phe Leu Ser Val Thr Leu Gly           
1               5                   10                  15                

gat cag act tct ata tct tgt agg tct agt cag agt ctg gaa tat agt         96
Asp Gln Thr Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser           
            20                  25                  30                    

gat gga tac act tat ttg gaa tgg tac cta cag aaa ccg ggc cag tct        144
Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctc atc tat gaa gtt tcc aac cga ttt tct ggg gtc cca        192
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc att ggc agt ggg tca ggg aca gat ttc acc ctc aag atc        240
Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gta gag cct gag gac ttg gga gtt tat tac tgc ttc caa ggt        288
Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly           
                85                  90                  95                

aca cat gat cct ctc acg ttc ggt tct ggg acc aag ctg gag atc aaa        336
Thr His Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  5
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5

Asp Val Val Leu Thr Gln Thr Pro Val Phe Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Thr Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr His Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  6
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequences obtained by sequencing of the variable regions of the 
       immunoglobulin genes expressed by rat hybridomas 
       BNT-8H4-B8/C7-E11, BNT-5E11-D4/G1-E4


<220>
<221>  CDS
<222>  (1)..(336)
<223>  BNT-5E11-D4/G1-E4_VH

<220>
<221>  V_region
<222>  (1)..(90)
<223>  FWR1

<220>
<221>  V_segment
<222>  (91)..(108)
<223>  CDR1

<220>
<221>  V_region
<222>  (109)..(150)
<223>  FWR2

<220>
<221>  V_segment
<222>  (151)..(198)
<223>  CDR2

<220>
<221>  V_region
<222>  (199)..(294)
<223>  FWR3

<220>
<221>  V_segment
<222>  (295)..(303)
<223>  CDR3

<220>
<221>  J_segment
<222>  (304)..(336)
<223>  JH

<400>  6
gag gtg cag ctg cag gag tca gga cct ggc ctt gtg aaa cct tca cag         48
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

tca ctc tcc ctc acc tgt tct gtc act ggt tac acc att acc agt ggt         96
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly           
            20                  25                  30                    

tat gat tgg agc tgg atc cgg agg ttc cca gga aat aca atg gag tgg        144
Tyr Asp Trp Ser Trp Ile Arg Arg Phe Pro Gly Asn Thr Met Glu Trp           
        35                  40                  45                        

atg gga gac ata agt tac agt ggt agc act aac tac aac cca tcg ctc        192
Met Gly Asp Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aaa agt cga gtc tcc att aca aga gac aca tcc aag aat cag ttc ttc        240
Lys Ser Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe           
65                  70                  75                  80            

ctg cag ttg aac tct gta act act ggg gat aca gcc aca tat tac tgt        288
Leu Gln Leu Asn Ser Val Thr Thr Gly Asp Thr Ala Thr Tyr Tyr Cys           
                85                  90                  95                

gca aaa cta ccc ggc tgg ggc caa ggc act ctg gtc act gtc tct tca        336
Ala Lys Leu Pro Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser           
            100                 105                 110                   


<210>  7
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Ser Trp Ile Arg Arg Phe Pro Gly Asn Thr Met Glu Trp 
        35                  40                  45              


Met Gly Asp Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Gly Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Pro Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  8
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequences obtained by sequencing of the variable regions of the 
       immunoglobulin genes expressed by rat hybridomas 
       BNT-8H4-B8/C7-E11, BNT-5E11-D4/G1-E4


<220>
<221>  CDS
<222>  (1)..(354)
<223>  BNT-8H4-B8/C7-E11_VH

<220>
<221>  V_region
<222>  (1)..(90)
<223>  FWR1

<220>
<221>  V_segment
<222>  (91)..(111)
<223>  CDR1

<220>
<221>  V_region
<222>  (112)..(153)
<223>  FWR2

<220>
<221>  V_segment
<222>  (154)..(201)
<223>  CDR2

<220>
<221>  V_region
<222>  (202)..(297)
<223>  FWR3

<220>
<221>  V_segment
<222>  (298)..(321)
<223>  CDR3

<220>
<221>  J_segment
<222>  (322)..(354)
<223>  JH

<400>  8
cag gtt act ctg aaa gag tct ggc cct ggg ata ttg cag cct tcc cag         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln           
1               5                   10                  15                

acc ctc agt ctg act tgc tct ttc tct ggg ttt tca ctg agc agt tca         96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Ser Ser           
            20                  25                  30                    

ggt ata tgt gtg agc tgg att cgt cag cct tca ggg aag ggt ctg gag        144
Gly Ile Cys Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg ctg gca act att tgt tgg gag gat agt aag ggc tac aac cct tct        192
Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Asn Pro Ser           
    50                  55                  60                            

ctg aag aac cgg ctc acg atc tcc aag gac acc tcc aac aac caa gca        240
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala           
65                  70                  75                  80            

ctc ctc agg atc acc agt gtg gac act gca gat acc gcc att tac tac        288
Leu Leu Arg Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Ile Tyr Tyr           
                85                  90                  95                

tgt gct cgg gtt tat tac tgg tac ttt gac ttc tgg ggc cca gga acc        336
Cys Ala Arg Val Tyr Tyr Trp Tyr Phe Asp Phe Trp Gly Pro Gly Thr           
            100                 105                 110                   

atg gtc acc gtg tcc tca                                                354
Met Val Thr Val Ser Ser                                                   
        115                                                               


<210>  9
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Gly Ile Cys Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Leu Leu Arg Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Tyr Tyr Trp Tyr Phe Asp Phe Trp Gly Pro Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  10
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1  of SEQ ID NO: 7

<400>  10

Ser Gly Tyr Asp Trp Ser 
1               5       


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 of SEQ ID NO: 7

<400>  11

Asp Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 of SEQ ID NO: 7

<400>  12

Leu Pro Gly 
1           


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1 of SEQ ID NO: 5

<400>  13

Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 of SEQ ID NO: 5

<400>  14

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 of SEQ ID NO: 5

<400>  15

Phe Gln Gly Thr His Asp Pro Leu Thr 
1               5                   


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1 of SEQ ID NO: 9

<400>  16

Ser Ser Gly Ile Cys Val Ser 
1               5           


<210>  17
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 of SEQ ID NO: 9

<400>  17

Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 of SEQ ID NO: 9

<400>  18

Val Tyr Tyr Trp Tyr Phe Asp Phe 
1               5               


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1 of SEQ ID NO: 3

<400>  19

Lys Gly Ser Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 of SEQ ID NO: 3

<400>  20

Asn Thr Asn Ser Leu Gln Thr 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3  of SEQ ID NO: 3

<400>  21

Tyr Gln Tyr Asn Asn Gly Asn Thr 
1               5               


