                         SEQUENCE LISTING

<110>  WuXi Biologics (Shanghai) Co. Ltd.
 
<120>  NOVEL ANTI-PCSK9 ANTIBODIES

<130>  053674-8010WO02

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Ser Tyr Trp Ile His 
1               5   


<210>  2
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  2
agctactgga tacac                                                        15


<210>  3
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Leu Asn Pro Ser Asp Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  4
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  4
gagcttaatc ctagcgacgg tcgtactaac tacaatgaga agttcaagaa c                51


<210>  5
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Asn Phe Tyr Gly Ser Ser Ser Phe Ala Asn 
1               5                   10      


<210>  6
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  6
tcgaatttct acggtagtag ctcctttgct aac                                    33


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  8
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  8
agtgccagct caagtgtaag ttacatgaac                                        30


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Ile Ser Asn Leu Ala Ser 
1               5           


<210>  10
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  10
ggtatatcca acctggcttc t                                                 21


<210>  11
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  12
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  12
cagcaaagga gtagttaccc acccacg                                           27


<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  13

Asn Tyr Val Met His 
1               5   


<210>  14
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  14
aactatgtta tgcac                                                        15


<210>  15
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  15

Tyr Ile Asn Pro Tyr Asn Asp Tyr Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  16
tatattaatc cttataatga ttatattaag tacaatgaga agttcaaagg c                51


<210>  17
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Arg Tyr Tyr Gly Tyr Arg Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  18
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  18
cagaggtact acggttatag accctactat gctatggact at                          42


<210>  19
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  19

Arg Ala Ser Glu Ser Val Asp Gly Tyr Gly Asn Val Phe Met His 
1               5                   10                  15  


<210>  20
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  20
agagccagtg aaagtgttga tggttatggc aatgttttta tgcac                       45


<210>  21
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  21

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  22
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  22
cttgcatcta acctggaatc t                                                 21


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Gln Gln Asn Asn Lys Asp Pro Trp Thr 
1               5                   


<210>  24
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  24
cagcaaaata ataaggatcc gtggacg                                           27


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Arg Ala Ser Glu Ser Val Glu Gly Tyr Gly Asn Val Phe Met His 
1               5                   10                  15  


<210>  26
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
cgggcctcag aaagtgtgga gggatacggg aacgtgttca tgcac                       45


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aactacgtga tgcac                                                        15


<210>  28
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
tatattaacc cctacaacga ctacatcaag tacaatgaga agtttaaagg g                51


<210>  29
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
cagcggtact acggctacag gccctactac gccatggatt at                          42


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
agctactgga tccac                                                        15


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gagctgaacc ccagtgatgg gaggacaaat tacaacgaga agtttaagaa c                51


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
tcaaacttct atggcagcag tagctttgcc aac                                    33


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
tccgccagtt catcagtgag ttacatgaat                                        30


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
ggaatctcca accttgccag c                                                 21


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
cagcagagga gcagctatcc acccacc                                           27


<210>  36
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Leu Asn Pro Ser Asp Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Phe Tyr Gly Ser Ser Ser Phe Ala Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  37
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  37
caggtccaac tgcagcagcc tggggctgaa gtggtgaagc ctggggcttc agtgacggtg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tacactgggt gatgcagaga      120

cctggacaag gccttgagtg gattggagag cttaatccta gcgacggtcg tactaactac      180

aatgagaagt tcaagaacaa ggccacactg actgtagaca catcgtccag tacagtctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagatcgaat      300

ttctacggta gtagctcctt tgctaactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  38
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  38

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Ile Leu Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Phe Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  39
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  39
gaaattttgc tcacccagtc tccagcaatc atagctgcat ctcctgggga gaaggtcacc       60

atcacctgca gtgccagctc aagtgtaagt tacatgaact ggtatcagca gaaaccagga      120

tcctccccca tactatggat ctatggtata tccaacctgg cttctggagt tcctgctcgc      180

ttcagcggca gtgggtctgg gacatctttc tctttcacaa tcaacaacat ggaggctgaa      240

gatgttgcca cttattactg tcagcaaagg agtagttacc cacccacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  40
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Tyr Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gln Arg Tyr Tyr Gly Tyr Arg Pro Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  41
<211>  369
<212>  DNA
<213>  Mus musculus

<400>  41
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcctc agtgaagatg       60

tcctgcgagg cttctggata cacattcact aactatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt ataatgatta tattaagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag tacaacctac      240

ctggaagtca gcagcctgac ctctgaggac tctgcggtct attactgtgg aagacagagg      300

tactacggtt atagacccta ctatgctatg gactattggg gtcagggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  42
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  42

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Tyr 
            20                  25                  30          


Gly Asn Val Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Lys Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  43
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  43
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctaggtca gagggccacc       60

atttcctgca gagccagtga aagtgttgat ggttatggca atgtttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatctaa cctggaatct      180

ggggtccctg acaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacttat tactgtcagc aaaataataa ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  44
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Tyr Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gln Arg Tyr Tyr Gly Tyr Arg Pro Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
caagtgcagc tcgtgcagtc tggagcagaa gtgaagaagc ctggatcatc cgtcaaggtg       60

agttgcgagg cttccgggta cacattcacc aactacgtga tgcactgggt cagacaggct      120

ccagggcagg ggcttgagtg gatggggtat attaacccct acaacgacta catcaagtac      180

aatgagaagt ttaaagggaa agccaccatc actgccgaca agagcaccag cacagcctac      240

atggagctgt ccagcctgag gagcgaggat acagccgtct actactgtgg ccgccagcgg      300

tactacggct acaggcccta ctacgccatg gattattggg gccagggcac tttggtgaca      360

gtcagctcc                                                              369


<210>  46
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Gly Tyr 
            20                  25                  30          


Gly Asn Val Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Lys Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  47
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gacatcgtct tgacccagtc tcctgcttcc cttgcagtgt cccctgggca aagagctact       60

attacctgcc gggcctcaga aagtgtggag ggatacggga acgtgttcat gcactggtac      120

cagcagaagc ccggacagcc accaaagctg ctcatctacc tggccagcaa cctcgagagc      180

ggcgtgcccg ccaggtttag cgggagcggc tccgggactg atttcacact gacaattaat      240

cccgtcgagg ccgacgatac agccaactat tactgtcagc agaacaacaa ggacccctgg      300

acatttggcg gcgggaccaa agtcgagatc aag                                   333


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Leu Asn Pro Ser Asp Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Phe Tyr Gly Ser Ser Ser Phe Ala Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
caggtgcaac ttgtgcagtc cggagcagaa gtgaagaagc caggggcttc agtgaaggtc       60

tcctgcaagg cttccggata caccttcacc agctactgga tccactgggt cagacaggcc      120

cctgggcagg gcttggagtg gatgggcgag ctgaacccca gtgatgggag gacaaattac      180

aacgagaagt ttaagaacaa agccaccatg accgtcgaca catccacaag cacagtgtac      240

atggagctct ccagcctgcg cagcgaggac actgccgtct actactgtgc ccggtcaaac      300

ttctatggca gcagtagctt tgccaactgg ggccagggga ctctggtgac tgtgtcttct      360


<210>  50
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  51
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
gacatccaaa tgacccagag cccttcttcc ctctccgctt ctgtcggaga tcgggtcaca       60

atcacatgct ccgccagttc atcagtgagt tacatgaatt ggtaccagca gaagcctggg      120

aaggcaccca agctgctgat ctacggaatc tccaaccttg ccagcggcgt gccaagcaga      180

ttctccggca gcgggagcgg gacagatttc acctttacaa ttagctcctt gcagcccgaa      240

gacattgcca cttactactg tcagcagagg agcagctatc cacccacctt tggcggcggg      300

actaaagtgg agattaag                                                    318


