                         SEQUENCE LISTING

<110>  RSEM, LIMITED PARTNERSHIP
       Sapieha, Przemyslaw
       Mallette, Frederick Antoine
       Oubaha, Malika
       Beaulieu, Normand
       Wilson, Ariel
 
<120>  COMPOSITIONS COMPRISING SASP MODULATORS AND SENESCENCE 
       ATTENUATORS AND USES THEREOF FOR MODULATING  CELLULAR SENESCENCE

<130>  787/12810.651

<150>  US 62/398,819
<151>  2016-09-23

<150>  US 62/398,797
<151>  2016-09-23

<150>  US 62/398,183
<151>  2016-09-22

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1
gacggccagg tcatcactat tg                                                22


<210>  2
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2
ctggtacatc agcacctcac a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3
ctctgggaaa tcgtggaaat g                                                 21


<210>  4
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4
ccgaacgtga tccgctactt ct                                                22


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5
ggccaatccc aagagcagag                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6
ctccactgct gcttcctgag                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7
ccgtgttggt tcatccctgt a                                                 21


<210>  8
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8
tgacgtcgtg gaactgc                                                      17


<210>  9
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9
gggacttcgc tatcttcaga ac                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10
ggactctcca cctgcaagac                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11
ctgagtccga atcaggtcca g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12
cgcgacgtgg aactggcaga a                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13
gccctgagtc aagaggacag                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14
caaggctttt gaaggcaaag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15
gtcacagatg tgccgaatgg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
ggcggtggtg acagtatctt                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17
ccacaggatt ccatacccaa ga                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18
gagctcctta acatgccctg                                                   20


<210>  19
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19
aagtgcatca tcgttgttca taca                                              24


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20
cgcaaagtcc ttctgctcca ca                                                22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21
gccacatgct agacacgcta                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22
tgctgagctc atgccctttg                                                   20


<210>  23
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23
ttttggattt ttaagacaga gtctttgta                                         29


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24
gaaagacttg tgaagtcggc                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25
ggcgtgcttt taggaatgtt g                                                 21


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26
catagatggc gttgttgcgg                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  27
gtccatggga agatgttctg g                                                 21


<210>  28
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28
cttggtggtt tgctacgacg tggg                                              24


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  29
ctcctaggcc cctcagaagt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  30
agaaggtgtt tgtggctgct                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  31
tgagcgtgat cagctccagg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32
gtcactgaca gaggcgatga                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  33
aaatccttga tattaaccag g                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  34
tttcccgtaa atatcacacc g                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  35
ttgaaactac tttaagaacg g                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  36
aaattagcac attctttcag g                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  37
aaattgccaa tataccaagg c                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  38
aatgagctgc atgaagtctc g                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  39
aaattggcac attctttcag g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  40
ttcattagga atacatcctg c                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  41
ttatttatag gaaacactgg g                                                 21


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  42
aacgccaccc atccaacca                                                    19


<210>  43
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  43
gcaagctgac cctgaagttc at                                                22


<210>  44
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  45
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  46
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Ala Glu 
    610                 615                 620                 


Thr Ile Phe Ile Pro Leu Leu Tyr His Phe Ser Ser Cys Leu Ser Trp 
625                 630                 635                 640 


Asp Gln Leu Thr Pro Val Cys Val Leu Val Thr Pro His Gly Arg Glu 
                645                 650                 655     


Leu Pro Arg Asn Arg Ser Cys Leu Ala Arg Thr Arg Ala Ser Ser Phe 
            660                 665                 670         


Pro His Val Ile Trp Ile Asp Glu Leu Phe Leu Ile Ala Thr Thr Ile 
        675                 680                 685             


Cys Asn Asn Asn Leu Ser His Phe Glu Ser Gln Arg Leu Gly Leu Ser 
    690                 695                 700                 


<210>  47
<211>  923
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (110)..(110)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (140)..(140)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (153)..(153)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (155)..(155)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (170)..(170)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (170)..(170)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (196)..(196)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (204)..(204)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (219)..(219)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (242)..(242)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (269)..(269)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (298)..(298)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (303)..(303)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (323)..(323)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (359)..(359)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (360)..(360)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (362)..(362)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (371)..(371)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (372)..(372)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (378)..(378)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (379)..(379)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (380)..(380)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (392)..(392)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (393)..(393)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (393)..(393)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (396)..(396)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (409)..(409)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (410)..(410)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (449)..(449)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (453)..(453)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (469)..(469)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (476)..(476)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (479)..(479)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (481)..(481)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (487)..(487)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (491)..(491)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (498)..(498)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (518)..(518)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (518)..(518)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (518)..(518)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (528)..(528)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (528)..(528)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (553)..(553)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (553)..(553)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (555)..(555)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (556)..(556)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (572)..(572)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (587)..(587)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (599)..(599)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (601)..(601)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (634)..(634)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (634)..(634)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (667)..(667)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (669)..(669)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (672)..(672)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (674)..(674)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (717)..(717)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (741)..(741)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (755)..(755)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (756)..(756)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (805)..(805)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (813)..(813)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (820)..(820)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (835)..(835)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (838)..(838)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (916)..(916)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (919)..(919)
<223>  X is any amino acid

<400>  47

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Xaa Leu Ala Leu Xaa Leu 
1               5                   10                  15      


Ala Xaa Ala Gly Ala Phe Arg Xaa Asp Lys Cys Gly Xaa Thr Ile Lys 
            20                  25                  30          


Ile Glu Xaa Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Xaa Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Xaa Asp Gly Glu Asn Glu Xaa 
                85                  90                  95      


Gly Xaa Xaa Xaa Gly Lys Phe Cys Gly Lys Ile Ala Pro Xaa Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Xaa Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Xaa Pro Xaa Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Xaa Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Xaa Asp Ser Asn Pro Pro Gly Gly Xaa Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Xaa Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Xaa Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Xaa Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Xaa Thr Asn Trp Ser Xaa Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Xaa Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Xaa Xaa Asp Xaa Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Xaa Xaa Lys Glu Gly Asn Lys Xaa Xaa Xaa Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Xaa Xaa Val Phe Xaa Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Xaa Xaa Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Xaa Ser Asn Gln Xaa Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Xaa Gly Trp Ala Leu Pro Pro Xaa Pro His Xaa Tyr 
465                 470                 475                 480 


Xaa Asn Glu Trp Leu Gln Xaa Asp Leu Gly Xaa Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Xaa Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Xaa Tyr Ser Asn Asn Gly Ser Asp Trp Lys Xaa 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Xaa Phe Xaa Xaa Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Xaa Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Xaa Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Xaa Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Xaa Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Xaa His Xaa Gln Leu Xaa 
            660                 665                 670         


Trp Xaa Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Xaa Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Xaa Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Xaa Xaa Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Xaa Gln Glu Asp Cys Ala Lys Pro Xaa Leu Asp Lys 
                805                 810                 815     


Lys Asn Asn Xaa Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Xaa Glu Gly Xaa Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Xaa Gln Ser Xaa Tyr Ser Glu Ala 
        915                 920             


<210>  48
<211>  923
<212>  PRT
<213>  Mus musculus

<400>  48

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920             


<210>  49
<211>  922
<212>  PRT
<213>  Ratus norvegicus

<400>  49

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Val Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Phe Gly Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Ala Phe Thr Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Val Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Arg Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu His Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Pro Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Glu Gly Lys Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn 
        835                 840                 845             


Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser 
    850                 855                 860                 


Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys 
865                 870                 875                 880 


Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu 
                885                 890                 895     


Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys 
            900                 905                 910         


Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920         


<210>  50
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  51
<211>  1308
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  51
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctgg atccaaggaa aacttgtatt tccagggc                  1308


<210>  52
<211>  436
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  52

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Lys 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu 
            420                 425                 430         


Tyr Phe Gln Gly 
        435     


<210>  53
<211>  1785
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  53
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctggatc caaggaaaac ttgtatttcc agggc                     1785


<210>  54
<211>  595
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  54

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Lys 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr 
            580                 585                 590         


Phe Gln Gly 
        595 


<210>  55
<211>  2154
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  55
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aaaagataac agattatcct      840

tgctctggaa tgttgggtat ggtgtctgga cttatttctg actcccagat cacatcatcc      900

aaccaagggg acagaaactg gatgcctgaa aacatccgcc tggtaaccag tcgctctggc      960

tgggcacttc cacccgcacc tcattcctac atcaatgagt ggctccaaat agacctgggg     1020

gaggagaaga tcgtgagggg catcatcatt cagggtggga agcaccgaga gaacaaggtg     1080

ttcatgagga agttcaagat cgggtacagc aacaacggct cggactggaa gatgatcatg     1140

gatgacagca aacgcaaggc gaagtctttt gagggcaaca acaactatga tacacctgag     1200

ctgcggactt ttccagctct ctccacgcga ttcatcagga tctaccccga gagagccact     1260

catggcggac tggggctcag aatggagctg ctgggctgtg aagtggaagc ccctacagct     1320

ggaccgacca ctcccaacgg gaacttggtg gatgaatgtg atgacgacca ggccaactgc     1380

cacagtggaa caggtgatga cttccagctc acaggtggca ccactgtgct ggccacagaa     1440

aagcccacgg tcatagacag caccatacaa tcagagtttc caacatatgg ttttaactgt     1500

gaatttggct ggggctctca caagaccttc tgccactggg aacatgacaa tcacgtgcag     1560

ctcaagtgga gtgtgttgac cagcaagacg ggacccattc aggatcacac aggagatggc     1620

aacttcatct attcccaagc tgacgaaaat cagaagggca aagtggctcg cctggtgagc     1680

cctgtggttt attcccagaa ctctgcccac tgcatgacct tctggtatca catgtctggg     1740

tcccacgtcg gcacactcag ggtcaaactg cgctaccaga agccagagga gtacgatcag     1800

ctggtctgga tggccattgg acaccaaggt gaccactgga aggaagggcg tgtcttgctc     1860

cacaagtctc tgaaacttta tcaggtgatt ttcgagggcg aaatcggaaa aggaaacctt     1920

ggtgggattg ctgtggatga cattagtatt aataaccaca tttcacaaga agattgtgca     1980

aaaccagcag acctggataa aaagaaccca gaaattaaaa ttgatgaaac agggagcacg     2040

ccaggatacg aaggtgaagg agaaggtgac aagaacatct ccaggaagcc aggcaatgtg     2100

ttgaagacct tagaccccag atctggatcc aaggaaaact tgtatttcca gggc           2154


<210>  56
<211>  718
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  56

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met Val 
        275                 280                 285             


Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly Asp 
    290                 295                 300                 


Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser Gly 
305                 310                 315                 320 


Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu Gln 
                325                 330                 335     


Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln Gly 
            340                 345                 350         


Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile Gly 
        355                 360                 365             


Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser Lys 
    370                 375                 380                 


Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro Glu 
385                 390                 395                 400 


Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr Pro 
                405                 410                 415     


Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu Gly 
            420                 425                 430         


Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn 
        435                 440                 445             


Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr 
    450                 455                 460                 


Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu 
465                 470                 475                 480 


Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr 
                485                 490                 495     


Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His 
            500                 505                 510         


Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser 
        515                 520                 525             


Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr 
    530                 535                 540                 


Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser 
545                 550                 555                 560 


Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr 
                565                 570                 575     


His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr 
            580                 585                 590         


Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His 
        595                 600                 605             


Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu 
    610                 615                 620                 


Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu 
625                 630                 635                 640 


Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln 
                645                 650                 655     


Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile 
            660                 665                 670         


Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu 
        675                 680                 685             


Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu 
    690                 695                 700                 


Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
705                 710                 715             


<210>  57
<211>  1335
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  57
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aaaagataac agattatcct      840

tgctctggaa tgttgggtat ggtgtctgga cttatttctg actcccagat cacatcatcc      900

aaccaagggg acagaaactg gatgcctgaa aacatccgcc tggtaaccag tcgctctggc      960

tgggcacttc cacccgcacc tcattcctac atcaatgagt ggctccaaat agacctgggg     1020

gaggagaaga tcgtgagggg catcatcatt cagggtggga agcaccgaga gaacaaggtg     1080

ttcatgagga agttcaagat cgggtacagc aacaacggct cggactggaa gatgatcatg     1140

gatgacagca aacgcaaggc gaagtctttt gagggcaaca acaactatga tacacctgag     1200

ctgcggactt ttccagctct ctccacgcga ttcatcagga tctaccccga gagagccact     1260

catggcggac tggggctcag aatggagctg ctgggctgta gatctggatc caaggaaaac     1320

ttgtatttcc agggc                                                      1335


<210>  58
<211>  445
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  58

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met Val 
        275                 280                 285             


Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly Asp 
    290                 295                 300                 


Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser Gly 
305                 310                 315                 320 


Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu Gln 
                325                 330                 335     


Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln Gly 
            340                 345                 350         


Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile Gly 
        355                 360                 365             


Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser Lys 
    370                 375                 380                 


Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro Glu 
385                 390                 395                 400 


Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr Pro 
                405                 410                 415     


Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu Gly 
            420                 425                 430         


Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        435                 440                 445 


<210>  59
<211>  2256
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  59
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaaag aggtcctgaa tgttcccaga actacacaac acctagtgga      120

gtgataaagt cccccggatt ccctgaaaaa tatcccaaca gccttgaatg cacttatatt      180

gtctttgcgc caaagatgtc agagattatc ctggaatttg aaagctttga cctggagcct      240

gactcaaatc ctccaggggg gatgttctgt cgctacgacc ggctagaaat ctgggatgga      300

ttccctgatg ttggccctca cattgggcgt tactgtggac agaaaacacc aggtcgaatc      360

cgatcctcat cgggcattct ctccatggtt ttttacaccg acagcgcgat agcaaaagaa      420

ggtttctcag caaactacag tgtcttgcag agcagtgtct cagaagattt caaatgtatg      480

gaagctctgg gcatggaatc aggagaaatt cattctgacc agatcacagc ttcttcccag      540

tatagcacca actggtctgc agagcgctcc cgcctgaact accctgagaa tgggtggact      600

cccggagagg attcctaccg agagtggata caggtagact tgggccttct gcgctttgtc      660

acggctgtcg ggacacaggg cgccatttca aaagaaacca agaagaaata ttatgtcaag      720

acttacaaga tcgacgttag ctccaacggg gaagactgga tcaccataaa agaaggaaac      780

aaacctgttc tctttcaggg aaacaccaac cctacagatg ttgtggttgc agtattcccc      840

aaaccactga taactcgatt tgtccgaatc aagcctgcaa cttgggaaac tggcatatct      900

atgagatttg aagtatatgg ttgcaagata acagattatc cttgctctgg aatgttgggt      960

atggtgtctg gacttatttc tgactcccag atcacatcat ccaaccaagg ggacagaaac     1020

tggatgcctg aaaacatccg cctggtaacc agtcgctctg gctgggcact tccacccgca     1080

cctcattcct acatcaatga gtggctccaa atagacctgg gggaggagaa gatcgtgagg     1140

ggcatcatca ttcagggtgg gaagcaccga gagaacaagg tgttcatgag gaagttcaag     1200

atcgggtaca gcaacaacgg ctcggactgg aagatgatca tggatgacag caaacgcaag     1260

gcgaagtctt ttgagggcaa caacaactat gatacacctg agctgcggac ttttccagct     1320

ctctccacgc gattcatcag gatctacccc gagagagcca ctcatggcgg actggggctc     1380

agaatggagc tgctgggctg tgaagtggaa gcccctacag ctggaccgac cactcccaac     1440

gggaacttgg tggatgaatg tgatgacgac caggccaact gccacagtgg aacaggtgat     1500

gacttccagc tcacaggtgg caccactgtg ctggccacag aaaagcccac ggtcatagac     1560

agcaccatac aatcagagtt tccaacatat ggttttaact gtgaatttgg ctggggctct     1620

cacaagacct tctgccactg ggaacatgac aatcacgtgc agctcaagtg gagtgtgttg     1680

accagcaaga cgggacccat tcaggatcac acaggagatg gcaacttcat ctattcccaa     1740

gctgacgaaa atcagaaggg caaagtggct cgcctggtga gccctgtggt ttattcccag     1800

aactctgccc actgcatgac cttctggtat cacatgtctg ggtcccacgt cggcacactc     1860

agggtcaaac tgcgctacca gaagccagag gagtacgatc agctggtctg gatggccatt     1920

ggacaccaag gtgaccactg gaaggaaggg cgtgtcttgc tccacaagtc tctgaaactt     1980

tatcaggtga ttttcgaggg cgaaatcgga aaaggaaacc ttggtgggat tgctgtggat     2040

gacattagta ttaataacca catttcacaa gaagattgtg caaaaccagc agacctggat     2100

aaaaagaacc cagaaattaa aattgatgaa acagggagca cgccaggata cgaaggtgaa     2160

ggagaaggtg acaagaacat ctccaggaag ccaggcaatg tgttgaagac cttagacccc     2220

agatctggat ccaaggaaaa cttgtatttc cagggc                               2256


<210>  60
<211>  752
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  60

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Arg Gly Pro Glu Cys Ser 
            20                  25                  30          


Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro 
        35                  40                  45              


Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro 
    50                  55                  60                  


Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro 
65                  70                  75                  80  


Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu 
                85                  90                  95      


Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys 
            100                 105                 110         


Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser 
        115                 120                 125             


Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala 
    130                 135                 140                 


Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met 
145                 150                 155                 160 


Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr 
                165                 170                 175     


Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu 
            180                 185                 190         


Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu 
        195                 200                 205             


Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly 
    210                 215                 220                 


Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys 
225                 230                 235                 240 


Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile 
                245                 250                 255     


Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr 
            260                 265                 270         


Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val 
        275                 280                 285             


Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu 
    290                 295                 300                 


Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly 
305                 310                 315                 320 


Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln 
                325                 330                 335     


Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg 
            340                 345                 350         


Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp 
        355                 360                 365             


Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile 
    370                 375                 380                 


Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys 
385                 390                 395                 400 


Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp 
                405                 410                 415     


Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr 
            420                 425                 430         


Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile 
        435                 440                 445             


Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu 
    450                 455                 460                 


Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn 
465                 470                 475                 480 


Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser 
                485                 490                 495     


Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala 
            500                 505                 510         


Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro 
        515                 520                 525             


Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe 
    530                 535                 540                 


Cys His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu 
545                 550                 555                 560 


Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe 
                565                 570                 575     


Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu 
            580                 585                 590         


Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe 
        595                 600                 605             


Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu 
    610                 615                 620                 


Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile 
625                 630                 635                 640 


Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys 
                645                 650                 655     


Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly 
            660                 665                 670         


Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile 
        675                 680                 685             


Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro 
    690                 695                 700                 


Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu 
705                 710                 715                 720 


Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys 
                725                 730                 735     


Thr Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
            740                 745                 750         


<210>  61
<211>  1437
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  61
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaaag aggtcctgaa tgttcccaga actacacaac acctagtgga      120

gtgataaagt cccccggatt ccctgaaaaa tatcccaaca gccttgaatg cacttatatt      180

gtctttgcgc caaagatgtc agagattatc ctggaatttg aaagctttga cctggagcct      240

gactcaaatc ctccaggggg gatgttctgt cgctacgacc ggctagaaat ctgggatgga      300

ttccctgatg ttggccctca cattgggcgt tactgtggac agaaaacacc aggtcgaatc      360

cgatcctcat cgggcattct ctccatggtt ttttacaccg acagcgcgat agcaaaagaa      420

ggtttctcag caaactacag tgtcttgcag agcagtgtct cagaagattt caaatgtatg      480

gaagctctgg gcatggaatc aggagaaatt cattctgacc agatcacagc ttcttcccag      540

tatagcacca actggtctgc agagcgctcc cgcctgaact accctgagaa tgggtggact      600

cccggagagg attcctaccg agagtggata caggtagact tgggccttct gcgctttgtc      660

acggctgtcg ggacacaggg cgccatttca aaagaaacca agaagaaata ttatgtcaag      720

acttacaaga tcgacgttag ctccaacggg gaagactgga tcaccataaa agaaggaaac      780

aaacctgttc tctttcaggg aaacaccaac cctacagatg ttgtggttgc agtattcccc      840

aaaccactga taactcgatt tgtccgaatc aagcctgcaa cttgggaaac tggcatatct      900

atgagatttg aagtatatgg ttgcaagata acagattatc cttgctctgg aatgttgggt      960

atggtgtctg gacttatttc tgactcccag atcacatcat ccaaccaagg ggacagaaac     1020

tggatgcctg aaaacatccg cctggtaacc agtcgctctg gctgggcact tccacccgca     1080

cctcattcct acatcaatga gtggctccaa atagacctgg gggaggagaa gatcgtgagg     1140

ggcatcatca ttcagggtgg gaagcaccga gagaacaagg tgttcatgag gaagttcaag     1200

atcgggtaca gcaacaacgg ctcggactgg aagatgatca tggatgacag caaacgcaag     1260

gcgaagtctt ttgagggcaa caacaactat gatacacctg agctgcggac ttttccagct     1320

ctctccacgc gattcatcag gatctacccc gagagagcca ctcatggcgg actggggctc     1380

agaatggagc tgctgggctg tagatctgga tccaaggaaa acttgtattt ccagggc        1437


<210>  62
<211>  479
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  62

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Arg Gly Pro Glu Cys Ser 
            20                  25                  30          


Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro 
        35                  40                  45              


Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro 
    50                  55                  60                  


Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro 
65                  70                  75                  80  


Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu 
                85                  90                  95      


Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys 
            100                 105                 110         


Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser 
        115                 120                 125             


Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala 
    130                 135                 140                 


Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met 
145                 150                 155                 160 


Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr 
                165                 170                 175     


Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu 
            180                 185                 190         


Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu 
        195                 200                 205             


Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly 
    210                 215                 220                 


Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys 
225                 230                 235                 240 


Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile 
                245                 250                 255     


Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr 
            260                 265                 270         


Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val 
        275                 280                 285             


Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu 
    290                 295                 300                 


Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly 
305                 310                 315                 320 


Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln 
                325                 330                 335     


Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg 
            340                 345                 350         


Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp 
        355                 360                 365             


Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile 
    370                 375                 380                 


Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys 
385                 390                 395                 400 


Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp 
                405                 410                 415     


Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr 
            420                 425                 430         


Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile 
        435                 440                 445             


Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu 
    450                 455                 460                 


Leu Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
465                 470                 475                 


<210>  63
<211>  960
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  63
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaaag aggtcctgaa tgttcccaga actacacaac acctagtgga      120

gtgataaagt cccccggatt ccctgaaaaa tatcccaaca gccttgaatg cacttatatt      180

gtctttgcgc caaagatgtc agagattatc ctggaatttg aaagctttga cctggagcct      240

gactcaaatc ctccaggggg gatgttctgt cgctacgacc ggctagaaat ctgggatgga      300

ttccctgatg ttggccctca cattgggcgt tactgtggac agaaaacacc aggtcgaatc      360

cgatcctcat cgggcattct ctccatggtt ttttacaccg acagcgcgat agcaaaagaa      420

ggtttctcag caaactacag tgtcttgcag agcagtgtct cagaagattt caaatgtatg      480

gaagctctgg gcatggaatc aggagaaatt cattctgacc agatcacagc ttcttcccag      540

tatagcacca actggtctgc agagcgctcc cgcctgaact accctgagaa tgggtggact      600

cccggagagg attcctaccg agagtggata caggtagact tgggccttct gcgctttgtc      660

acggctgtcg ggacacaggg cgccatttca aaagaaacca agaagaaata ttatgtcaag      720

acttacaaga tcgacgttag ctccaacggg gaagactgga tcaccataaa agaaggaaac      780

aaacctgttc tctttcaggg aaacaccaac cctacagatg ttgtggttgc agtattcccc      840

aaaccactga taactcgatt tgtccgaatc aagcctgcaa cttgggaaac tggcatatct      900

atgagatttg aagtatatgg ttgcagatct ggatccaagg aaaacttgta tttccagggc      960


<210>  64
<211>  320
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  64

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Arg Gly Pro Glu Cys Ser 
            20                  25                  30          


Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro 
        35                  40                  45              


Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro 
    50                  55                  60                  


Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro 
65                  70                  75                  80  


Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu 
                85                  90                  95      


Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys 
            100                 105                 110         


Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser 
        115                 120                 125             


Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala 
    130                 135                 140                 


Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met 
145                 150                 155                 160 


Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr 
                165                 170                 175     


Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu 
            180                 185                 190         


Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu 
        195                 200                 205             


Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly 
    210                 215                 220                 


Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys 
225                 230                 235                 240 


Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile 
                245                 250                 255     


Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr 
            260                 265                 270         


Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val 
        275                 280                 285             


Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu 
    290                 295                 300                 


Val Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
305                 310                 315                 320 


<210>  65
<211>  1797
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  65
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaaag aggtcctgaa tgttcccaga actacacaac acctagtgga      120

gtgataaagt cccccggatt ccctgaaaaa tatcccaaca gccttgaatg cacttatatt      180

gtctttgcgc caaagatgtc agagattatc ctggaatttg aaagctttga cctggagcct      240

gactcaaatc ctccaggggg gatgttctgt cgctacgacc ggctagaaat ctgggatgga      300

ttccctgatg ttggccctca cattgggcgt tactgtggac agaaaacacc aggtcgaatc      360

cgatcctcat cgggcattct ctccatggtt ttttacaccg acagcgcgat agcaaaagaa      420

ggtttctcag caaactacag tgtcttgcag agcagtgtct cagaagattt caaatgtatg      480

gaagctctgg gcatggaatc aggagaaatt cattctgacc agatcacagc ttcttcccag      540

tatagcacca actggtctgc agagcgctcc cgcctgaact accctgagaa tgggtggact      600

cccggagagg attcctaccg agagtggata caggtagact tgggccttct gcgctttgtc      660

acggctgtcg ggacacaggg cgccatttca aaagaaacca agaagaaata ttatgtcaag      720

acttacaaga tcgacgttag ctccaacggg gaagactgga tcaccataaa agaaggaaac      780

aaacctgttc tctttcaggg aaacaccaac cctacagatg ttgtggttgc agtattcccc      840

aaaccactga taactcgatt tgtccgaatc aagcctgcaa cttgggaaac tggcatatct      900

atgagatttg aagtatatgg ttgcaagata acagattatc ctgaagtgga agcccctaca      960

gctggaccga ccactcccaa cgggaacttg gtggatgaat gtgatgacga ccaggccaac     1020

tgccacagtg gaacaggtga tgacttccag ctcacaggtg gcaccactgt gctggccaca     1080

gaaaagccca cggtcataga cagcaccata caatcagagt ttccaacata tggttttaac     1140

tgtgaatttg gctggggctc tcacaagacc ttctgccact gggaacatga caatcacgtg     1200

cagctcaagt ggagtgtgtt gaccagcaag acgggaccca ttcaggatca cacaggagat     1260

ggcaacttca tctattccca agctgacgaa aatcagaagg gcaaagtggc tcgcctggtg     1320

agccctgtgg tttattccca gaactctgcc cactgcatga ccttctggta tcacatgtct     1380

gggtcccacg tcggcacact cagggtcaaa ctgcgctacc agaagccaga ggagtacgat     1440

cagctggtct ggatggccat tggacaccaa ggtgaccact ggaaggaagg gcgtgtcttg     1500

ctccacaagt ctctgaaact ttatcaggtg attttcgagg gcgaaatcgg aaaaggaaac     1560

cttggtggga ttgctgtgga tgacattagt attaataacc acatttcaca agaagattgt     1620

gcaaaaccag cagacctgga taaaaagaac ccagaaatta aaattgatga aacagggagc     1680

acgccaggat acgaaggtga aggagaaggt gacaagaaca tctccaggaa gccaggcaat     1740

gtgttgaaga ccttagaccc cagatctgga tccaaggaaa acttgtattt ccagggc        1797


<210>  66
<211>  599
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  66

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Arg Gly Pro Glu Cys Ser 
            20                  25                  30          


Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro 
        35                  40                  45              


Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro 
    50                  55                  60                  


Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro 
65                  70                  75                  80  


Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu 
                85                  90                  95      


Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys 
            100                 105                 110         


Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser 
        115                 120                 125             


Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala 
    130                 135                 140                 


Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met 
145                 150                 155                 160 


Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr 
                165                 170                 175     


Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu 
            180                 185                 190         


Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu 
        195                 200                 205             


Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly 
    210                 215                 220                 


Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys 
225                 230                 235                 240 


Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile 
                245                 250                 255     


Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr 
            260                 265                 270         


Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val 
        275                 280                 285             


Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu 
    290                 295                 300                 


Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr 
305                 310                 315                 320 


Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp 
                325                 330                 335     


Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr 
            340                 345                 350         


Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser 
        355                 360                 365             


Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly 
    370                 375                 380                 


Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val 
385                 390                 395                 400 


Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp 
                405                 410                 415     


His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln 
            420                 425                 430         


Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn 
        435                 440                 445             


Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val 
    450                 455                 460                 


Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp 
465                 470                 475                 480 


Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu 
                485                 490                 495     


Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe 
            500                 505                 510         


Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp 
        515                 520                 525             


Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala 
    530                 535                 540                 


Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser 
545                 550                 555                 560 


Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg 
                565                 570                 575     


Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Gly Ser Lys 
            580                 585                 590         


Glu Asn Leu Tyr Phe Gln Gly 
        595                 


<210>  67
<211>  2604
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  67
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggc                                            2604


<210>  68
<211>  847
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  68

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        835                 840                 845         


<210>  69
<211>  2604
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  69
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggc                                            2604


<210>  70
<211>  847
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  70

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        835                 840                 845         


<210>  71
<211>  2604
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  71
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggaaagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggc                                            2604


<210>  72
<211>  847
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  72

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Lys Lys Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        835                 840                 845         


<210>  73
<211>  2604
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  73
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccattgccaa aaagaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggc                                            2604


<210>  74
<211>  847
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  74

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ala Lys Lys Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        835                 840                 845         


<210>  75
<211>  2604
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  75
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagagaag      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg     1800

gatgaatgtg atgacgacca ggccaactgc cacagtggaa caggtgatga cttccagctc     1860

acaggtggca ccactgtgct ggccacagaa aagcccacgg tcatagacag caccatacaa     1920

tcagagtttc caacatatgg ttttaactgt gaatttggct ggggctctca caagaccttc     1980

tgccactggg aacatgacaa tcacgtgcag ctcaagtgga gtgtgttgac cagcaagacg     2040

ggacccattc aggatcacac aggagatggc aacttcatct attcccaagc tgacgaaaat     2100

cagaagggca aagtggctcg cctggtgagc cctgtggttt attcccagaa ctctgcccac     2160

tgcatgacct tctggtatca catgtctggg tcccacgtcg gcacactcag ggtcaaactg     2220

cgctaccaga agccagagga gtacgatcag ctggtctgga tggccattgg acaccaaggt     2280

gaccactgga aggaagggcg tgtcttgctc cacaagtctc tgaaacttta tcaggtgatt     2340

ttcgagggcg aaatcggaaa aggaaacctt ggtgggattg ctgtggatga cattagtatt     2400

aataaccaca tttcacaaga agattgtgca aaaccagcag acctggataa aaagaaccca     2460

gaaattaaaa ttgatgaaac agggagcacg ccaggatacg aaggtgaagg agaaggtgac     2520

aagaacatct ccaggaagcc aggcaatgtg ttgaagacct tagaccccag atctggatcc     2580

aaggaaaact tgtatttcca gggc                                            2604


<210>  76
<211>  847
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  76

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Lys Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                565                 570                 575     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            580                 585                 590         


Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr 
        595                 600                 605             


Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr 
    610                 615                 620                 


Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys 
625                 630                 635                 640 


His Trp Glu His Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr 
                645                 650                 655     


Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile 
            660                 665                 670         


Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val 
        675                 680                 685             


Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp 
    690                 695                 700                 


Tyr His Met Ser Gly Ser His Val Gly Thr Leu Arg Val Lys Leu Arg 
705                 710                 715                 720 


Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly 
                725                 730                 735     


His Gln Gly Asp His Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser 
            740                 745                 750         


Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn 
        755                 760                 765             


Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser 
    770                 775                 780                 


Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu 
785                 790                 795                 800 


Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr 
            820                 825                 830         


Leu Asp Pro Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
        835                 840                 845         


<210>  77
<211>  1785
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  77
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctggatc caaggaaaac ttgtatttcc agggc                     1785


<210>  78
<211>  574
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  78

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                565                 570                 


<210>  79
<211>  1785
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  79
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct tgctctggaa tgttgggtat ggtgtctgga     1320

cttatttctg actcccagat cacatcatcc aaccaagggg acagaaactg gatgcctgaa     1380

aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac     1440

atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt     1500

cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc     1560

aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt     1620

gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga     1680

ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg     1740

ctgggctgta gatctggatc caaggaaaac ttgtatttcc agggc                     1785


<210>  80
<211>  574
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  80

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                405                 410                 415     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            420                 425                 430         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        435                 440                 445             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    450                 455                 460                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
465                 470                 475                 480 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                485                 490                 495     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            500                 505                 510         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        515                 520                 525             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    530                 535                 540                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
545                 550                 555                 560 


Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                565                 570                 


<210>  81
<211>  1308
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  81
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctgg atccaaggaa aacttgtatt tccagggc                  1308


<210>  82
<211>  415
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  82

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                405                 410                 415 


<210>  83
<211>  1308
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  83
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcagatctgg atccaaggaa aacttgtatt tccagggc                  1308


<210>  84
<211>  415
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  84

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                405                 410                 415 


<210>  85
<211>  831
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  85
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgagatc tggatccaag gaaaacttgt atttccaggg c               831


<210>  86
<211>  256
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  86

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Arg Ser Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
                245                 250                 255     


<210>  87
<211>  2145
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  87
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctggatc caaggaaaac ttgtatttcc agggc                     2145


<210>  88
<211>  694
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  88

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Gly Ser Lys Glu 
        675                 680                 685             


Asn Leu Tyr Phe Gln Gly 
    690                 


<210>  89
<211>  2145
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  89
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccaggc tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatctggatc caaggaaaac ttgtatttcc agggc                     2145


<210>  90
<211>  694
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  90

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Ala Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser Gly Ser Lys Glu 
        675                 680                 685             


Asn Leu Tyr Phe Gln Gly 
    690                 


<210>  91
<211>  1677
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  91
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aagaagtgga agcccctaca      840

gctggaccga ccactcccaa cgggaacttg gtggatgaat gtgatgacga ccaggccaac      900

tgccacagtg gaacaggtga tgacttccag ctcacaggtg gcaccactgt gctggccaca      960

gaaaagccca cggtcataga cagcaccata caatcagagt ttccaacata tggttttaac     1020

tgtgaatttg gctggggctc tcacaagacc ttctgccact gggaacatga caatcacgtg     1080

cagctcaagt ggagtgtgtt gaccagcaag acgggaccca ttcaggatca cacaggagat     1140

ggcaacttca tctattccca agctgacgaa aatcagaagg gcaaagtggc tcgcctggtg     1200

agccctgtgg tttattccca gaactctgcc cactgcatga ccttctggta tcacatgtct     1260

gggtcccacg tcggcacact cagggtcaaa ctgcgctacc agaagccaga ggagtacgat     1320

cagctggtct ggatggccat tggacaccaa ggtgaccact ggaaggaagg gcgtgtcttg     1380

ctccacaagt ctctgaaact ttatcaggtg attttcgagg gcgaaatcgg aaaaggaaac     1440

cttggtggga ttgctgtgga tgacattagt attaataacc acatttcaca agaagattgt     1500

gcaaaaccag cagacctgga taaaaagaac ccagaaatta aaattgatga aacagggagc     1560

acgccaggat acgaaggtga aggagaaggt gacaagaaca tctccaggaa gccaggcaat     1620

gtgttgaaga ccttagaccc cagatctgga tccaaggaaa acttgtattt ccagggc        1677


<210>  92
<211>  538
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  92

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Glu Val Glu 
                245                 250                 255     


Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu 
            260                 265                 270         


Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe 
        275                 280                 285             


Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val 
    290                 295                 300                 


Ile Asp Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys 
305                 310                 315                 320 


Glu Phe Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp 
                325                 330                 335     


Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro 
            340                 345                 350         


Ile Gln Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp 
        355                 360                 365             


Glu Asn Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr 
    370                 375                 380                 


Ser Gln Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly 
385                 390                 395                 400 


Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu 
                405                 410                 415     


Glu Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His 
            420                 425                 430         


Trp Lys Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln 
        435                 440                 445             


Val Ile Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala 
    450                 455                 460                 


Val Asp Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala 
465                 470                 475                 480 


Lys Pro Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu 
                485                 490                 495     


Thr Gly Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn 
            500                 505                 510         


Ile Ser Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Arg Ser 
        515                 520                 525             


Gly Ser Lys Glu Asn Leu Tyr Phe Gln Gly 
    530                 535             


<210>  93
<211>  2115
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  93
atggagaggg ggctgccgct cctctgcgcc gtgctcgccc tcgtcctcgc cccggccggc       60

gcttttcgca acgataaatg tggcgatact ataaaaattg aaagccccgg gtaccttaca      120

tctcctggtt atcctcattc ttatcaccca agtgaaaaat gcgaatggct gattcaggct      180

ccggacccat accagagaat tatgatcaac ttcaaccctc acttcgattt ggaggacaga      240

gactgcaagt atgactacgt ggaagtcttc gatggagaaa atgaaaatgg acattttagg      300

ggaaagttct gtggaaagat agcccctcct cctgttgtgt cttcagggcc atttcttttt      360

atcaaatttg tctctgacta cgaaacacat ggtgcaggat tttccatacg ttatgaactt      420

ttcaagagag gtcctgaatg ttcccagaac tacacaacac ctagtggagt gataaagtcc      480

cccggattcc ctgaaaaata tcccaacagc cttgaatgca cttatattgt ctttgcgcca      540

aagatgtcag agattatcct ggaatttgaa agctttgacc tggagcctga ctcaaatcct      600

ccagggggga tgttctgtcg ctacgaccgg ctagaaatct gggatggatt ccctgatgtt      660

ggccctcaca ttgggcgtta ctgtggacag aaaacaccag gtcgaatccg atcctcatcg      720

ggcattctct ccatggtttt ttacaccgac agcgcgatag caaaagaagg tttctcagca      780

aactacagtg tcttgcagag cagtgtctca gaagatttca aatgtatgga agctctgggc      840

atggaatcag gagaaattca ttctgaccag atcacagctt cttcccagta tagcaccaac      900

tggtctgcag agcgctcccg cctgaactac cctgagaatg ggtggactcc cggagaggat      960

tcctaccgag agtggataca ggtagacttg ggccttctgc gctttgtcac ggctgtcggg     1020

acacagggcg ccatttcaaa agaaaccaag aagaaatatt atgtcaagac ttacaagatc     1080

gacgttagct ccaacgggga agactggatc accataaaag aaggaaacaa acctgttctc     1140

tttcagggaa acaccaaccc tacagatgtt gtggttgcag tattccccaa accactgata     1200

actcgatttg tccgaatcaa gcctgcaact tgggaaactg gcatatctat gagatttgaa     1260

gtatatggtt gcaagataac agattatcct gaagtggaag cccctacagc tggaccgacc     1320

actcccaacg ggaacttggt ggatgaatgt gatgacgacc aggccaactg ccacagtgga     1380

acaggtgatg acttccagct cacaggtggc accactgtgc tggccacaga aaagcccacg     1440

gtcatagaca gcaccataca atcagagttt ccaacatatg gttttaactg tgaatttggc     1500

tggggctctc acaagacctt ctgccactgg gaacatgaca atcacgtgca gctcaagtgg     1560

agtgtgttga ccagcaagac gggacccatt caggatcaca caggagatgg caacttcatc     1620

tattcccaag ctgacgaaaa tcagaagggc aaagtggctc gcctggtgag ccctgtggtt     1680

tattcccaga actctgccca ctgcatgacc ttctggtatc acatgtctgg gtcccacgtc     1740

ggcacactca gggtcaaact gcgctaccag aagccagagg agtacgatca gctggtctgg     1800

atggccattg gacaccaagg tgaccactgg aaggaagggc gtgtcttgct ccacaagtct     1860

ctgaaacttt atcaggtgat tttcgagggc gaaatcggaa aaggaaacct tggtgggatt     1920

gctgtggatg acattagtat taataaccac atttcacaag aagattgtgc aaaaccagca     1980

gacctggata aaaagaaccc agaaattaaa attgatgaaa cagggagcac gccaggatac     2040

gaaggtgaag gagaaggtga caagaacatc tccaggaagc caggcaatgt gttgaagacc     2100

ttagacccca gatct                                                      2115


<210>  94
<211>  682
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  94

Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys Ile Glu Ser Pro Gly 
1               5                   10                  15      


Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr His Pro Ser Glu Lys 
            20                  25                  30          


Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr Gln Arg Ile Met Ile 
        35                  40                  45              


Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg Asp Cys Lys Tyr Asp 
    50                  55                  60                  


Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn Gly His Phe Arg Gly 
65                  70                  75                  80  


Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val Val Ser Ser Gly Pro 
                85                  90                  95      


Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu Thr His Gly Ala Gly 
            100                 105                 110         


Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly Pro Glu Cys Ser Gln 
        115                 120                 125             


Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser Pro Gly Phe Pro Glu 
    130                 135                 140                 


Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile Val Phe Ala Pro Lys 
145                 150                 155                 160 


Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
                165                 170                 175     


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            180                 185                 190         


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        195                 200                 205             


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    210                 215                 220                 


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
225                 230                 235                 240 


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                245                 250                 255     


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            260                 265                 270         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        275                 280                 285             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    290                 295                 300                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
305                 310                 315                 320 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                325                 330                 335     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            340                 345                 350         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        355                 360                 365             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    370                 375                 380                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
385                 390                 395                 400 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Glu Val Glu Ala Pro Thr Ala 
                405                 410                 415     


Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp 
            420                 425                 430         


Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly 
        435                 440                 445             


Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr 
    450                 455                 460                 


Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp 
465                 470                 475                 480 


Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln 
                485                 490                 495     


Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
            500                 505                 510         


Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys 
        515                 520                 525             


Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser 
    530                 535                 540                 


Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly 
545                 550                 555                 560 


Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln 
                565                 570                 575     


Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly 
            580                 585                 590         


Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu 
        595                 600                 605             


Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile 
    610                 615                 620                 


Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp 
625                 630                 635                 640 


Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr 
                645                 650                 655     


Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys 
            660                 665                 670         


Pro Gly Asn Val Leu Lys Thr Leu Asp Pro 
        675                 680         


<210>  95
<211>  923
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  95

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Val Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Phe Gly Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Ala Phe Thr Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Val Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Arg Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu His Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Pro Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Glu Glu Gly Lys Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920             


<210>  96
<211>  923
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  96

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  97
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  97

Glu Xaa Xaa Tyr Xaa Gln Gly 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid

<400>  98

Glu Xaa Xaa Tyr Xaa Gln Ser 
1               5           


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRP1 forward primer

<400>  99
acccacattt cgatttggag                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRP1 reverse primer

<400>  100
ttcatagcgg atggaaaacc                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEMA3A forward primer

<400>  101
gctcctgctc cgtagcctgc                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEMA3A Reverse primer

<400>  102
tcggcgttgc tttcggtccc                                                   20


<210>  103
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEMA3e forward primer

<400>  103
tctgcaacca tcca                                                         14


<210>  104
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEMA3e reverse primer

<400>  104
accacaagag ggaagcacag ac                                                22


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFb forward primer

<400>  105
ggactctcca cctgcaagac                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFb reverse primer

<400>  106
catagatggc gttgttgcgg                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFa forward primer

<400>  107
gccctgagtc aagaggacag                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFa reverse primer

<400>  108
ctcctaggcc cctcagaagt                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFb forward primer

<400>  109
tctgagcatg gaactcatgg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFb reverse primer

<400>  110
tctgcattca cattggctgt                                                   20


