                         SEQUENCE LISTING

<110>  Idera Pharmaceuticals Inc.
       Agrawal, Sudhir
       WANG, Daqing
       JIANG, Wayne
 
<120>  IMMUNE MODULATION WITH TLR9 AGONISTS FOR CANCER TREATMENT

<130>  105968-5001PC

<140>  PCT/US17/51742
<141>  2017-09-15

<150>  62/394,845
<151>  2016-09-15

<150>  62/486,738
<151>  2017-04-18

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<400>  1
tctgacgttc ttcttgcagt ct                                                22


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<400>  2
tctgtcgttc ttcttgctgt ct                                                22


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  3
tcgtcgttct ggtcttgctg ct                                                22


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by is a glycerol linker

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  4
tcgaacgttc ggcttgcaag ct                                                22


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  phosphodiester linkage

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Phosphodiester linkage

<400>  5
ctgtcgttct cctcttgctg tc                                                22


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-arabinoguanosine

<400>  6
ctgtcgttct cctcttgctg tc                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-arabinoguanosine

<400>  7
tcgaacgttc gtcttgctgt ct                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a C3-linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<400>  8
tcgaacgttc ggacagctgt ct                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-arabinoguanosine

<400>  9
cagtcgttca ggacttgctg ac                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-7-deazaguanosine

<400>  10
cagtcgttca ggacttgctg ac                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3,5-pentanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  11
tcgaacgttc ggcttgcaag ct                                                22


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3-propanediol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2'-deoxy-7-deazaguanosine

<400>  12
tcgaacgttc gtcttgctgt cttgct                                            26


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3-propanediol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methylribonucleotide

<400>  13
tcgaacgttc gtcttgctgu ct                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a cis,trans-1,3,5-cyclohexanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  14
tcgaacgttc ggcttgcaag ct                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,4-butanediol linker

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-arabinoguanosine

<400>  15
tcgaacgttc ggacttgctg ac                                                22


<210>  16
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2'-deoxy-7-deazaguanosine

<400>  16
tcgaacgttc gtgttgctgt cttgct                                            26


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-U

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by a cis,cis-1,3,5-cyclohexanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-U

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-arabinoguanosine

<400>  17
tcgtcgttuy yuttgctgct                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,4-butanediol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<400>  18
cagtcgttca gtcttgctgt ct                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a glycerol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  19
tcgtacgtac ggcatgcatg ct                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3,5-pentanetriol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  20
tcgaacgttc ggcttgcaag ct                                                22


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,4-butanediol linker

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-deoxy-7-deazaguanosine

<400>  21
tcgaacgttc gcttgctgac ttgct                                             25


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a isobutanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  22
tcgaacgttc ggcttgcaag ct                                                22


<210>  23
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,5-pentandiol linker

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2'-deoxy-7-deazaguanosine

<400>  23
tcgaacgttc gcattgctgt cttgct                                            26


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a cis,trans-1,3,5-cyclohexanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<400>  24
tcgaacgttc ggcttgcaag ct                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a isobutanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  a phosphodiester linkage

<400>  25
tcgaacgttc ggcttgcaag ct                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Linked by an isobutanetriol linker

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<400>  26
tcgaacgttc ggcttgcaag ct                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a cis,trans-1,3,5-cyclohexanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  a phosphodiester linkage

<400>  27
tcgaacgttc ggcttgcaag ct                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by an isobutanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-arabinoguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  a phosphodiester linkage

<400>  28
tcgaacgttc ggcttgcaag ct                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3,5-pentanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  a phosphodiester linkage

<400>  29
tcgaacgttc ggcttgcaag ct                                                22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Linked by a 1,3,5-pentanetriol linker

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  a phosphodiester linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxy-7-deazaguanosine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  a phosphodiester linkage

<400>  30
tcgaacgttc ggcttgcaag ct                                                22


