                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
      UNIVERSITY OF OSLO
 
<120> BLOCKADE OF ALPHAFETOPROTEIN (AFP) INTERACTIONS WITH 
      BETA2-MICROGLOBULIN ASSOCIATED MOLECULES

<130> 043214-086861-PCT

<140> PCT/US2017/051462
<141> 2017-09-14

<150> 62/395,696
<151> 2016-09-16

<160> 131   

<170> PatentIn version 3.5

<210> 1
<211> 609
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210> 2
<211> 591
<212> PRT
<213> Homo sapiens

<400> 2
Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu Asp Ser 
1               5                   10                  15      


Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr Ile Phe 
            20                  25                  30          


Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser Lys Met 
        35                  40                  45              


Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp Glu Gln 
    50                  55                  60                  


Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu Glu Leu 
65                  70                  75                  80  


Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp Cys Cys 
                85                  90                  95      


Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His Lys Lys 
            100                 105                 110         


Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro Val Thr 
        115                 120                 125             


Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn Lys Phe 
    130                 135                 140                 


Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro Thr Ile 
145                 150                 155                 160 


Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys Cys Lys 
                165                 170                 175     


Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr Val Thr 
            180                 185                 190         


Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys Ala Val 
        195                 200                 205             


Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val Thr Lys 
    210                 215                 220                 


Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln Lys Leu 
225                 230                 235                 240 


Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly Asp Val 
                245                 250                 255     


Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile Cys Ser 
            260                 265                 270         


Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys Leu Thr 
        275                 280                 285             


Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp Glu Lys 
    290                 295                 300                 


Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp Arg Asp 
305                 310                 315                 320 


Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala Ser Phe 
                325                 330                 335     


Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser Val Ile 
            340                 345                 350         


Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys Phe Gln 
        355                 360                 365             


Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu Leu Gln 
    370                 375                 380                 


Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys Gly Leu 
385                 390                 395                 400 


Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu Val Ala 
                405                 410                 415     


Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met Ala Ile 
            420                 425                 430         


Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu Ser Glu 
        435                 440                 445             


Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile Ile Gly 
    450                 455                 460                 


His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly Val Gly 
465                 470                 475                 480 


Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe Ser Ser 
                485                 490                 495     


Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys 
            500                 505                 510         


Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln 
        515                 520                 525             


Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys Pro Gln 
    530                 535                 540                 


Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser Gly Leu 
545                 550                 555                 560 


Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe Ala Glu 
                565                 570                 575     


Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly Val 
            580                 585                 590     


<210> 3
<211> 119
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210> 4
<211> 99
<212> PRT
<213> Homo sapiens

<400> 4
Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210> 5
<211> 365
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210> 6
<211> 341
<212> PRT
<213> Homo sapiens

<400> 6
Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Leu Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ala Val Ile Thr Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Met Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Thr Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu 
                325                 330                 335     


Thr Ala Cys Lys Val 
            340     


<210> 7
<211> 362
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210> 8
<211> 338
<212> PRT
<213> Homo sapiens

<400> 8
Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Ser Thr Val Pro Ile Val Gly Ile Val 
        275                 280                 285             


Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu 
                325                 330                 335     


Thr Ala 
        


<210> 9
<211> 366
<212> PRT
<213> Homo sapiens

<400> 9
Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210> 10
<211> 342
<212> PRT
<213> Homo sapiens

<400> 10
Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Ser Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu 
            260                 265                 270         


Ser Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Met Gly Ile Val 
        275                 280                 285             


Ala Gly Leu Ala Val Leu Val Val Leu Ala Val Leu Gly Ala Val Val 
    290                 295                 300                 


Thr Ala Met Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly Gly Ser 
305                 310                 315                 320 


Cys Ser Gln Ala Ala Cys Ser Asn Ser Ala Gln Gly Ser Asp Glu Ser 
                325                 330                 335     


Leu Ile Thr Cys Lys Ala 
            340         


<210> 11
<211> 358
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210> 12
<211> 337
<212> PRT
<213> Homo sapiens

<400> 12
Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
    130                 135                 140                 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser 
                325                 330                 335     


Leu 
    


<210> 13
<211> 346
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
            340                 345     


<210> 14
<211> 325
<212> PRT
<213> Homo sapiens

<400> 14
Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr Trp Glu Trp Thr Thr 
    50                  55                  60                  


Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg Val Ala Leu Arg Asn 
65                  70                  75                  80  


Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr Ile Ser Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu Phe Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala His Val Ala His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Glu Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Gln Pro Leu Ile Leu 
            260                 265                 270         


Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro Ile Val Gly Ile Val 
        275                 280                 285             


Ala Gly Leu Val Val Leu Gly Ala Val Val Thr Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg Asn Arg Gly Ser Tyr 
305                 310                 315                 320 


Ser Gln Ala Ala Val 
                325 


<210> 15
<211> 338
<212> PRT
<213> Homo sapiens

<400> 15
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210> 16
<211> 314
<212> PRT
<213> Homo sapiens

<400> 16
Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu 
            260                 265                 270         


Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val 
        275                 280                 285             


Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala 
    290                 295                 300                 


Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
305                 310                 


<210> 17
<211> 298
<212> PRT
<213> Homo sapiens

<400> 17
Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210> 18
<211> 278
<212> PRT
<213> Homo sapiens

<400> 18
Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr Ile Tyr Thr Gly 
1               5                   10                  15      


Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln Ala Leu Gly Ser 
            20                  25                  30          


Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys Asp Arg Lys Ser 
        35                  40                  45              


Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met Glu Asp Trp Lys 
    50                  55                  60                  


Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile Phe Met Glu Thr 
65                  70                  75                  80  


Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn Gly Ser His Val 
                85                  90                  95      


Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn Arg Ser Ser Gly 
            100                 105                 110         


Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr Ile Glu Phe Asn 
        115                 120                 125             


Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala Ala Gln Ile Thr 
    130                 135                 140                 


Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln Arg Ala Lys Ala 
145                 150                 155                 160 


Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys Tyr Leu Lys Tyr 
                165                 170                 175     


Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser Val Val Val Thr 
            180                 185                 190         


Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys Cys Leu Ala Tyr 
        195                 200                 205             


Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr Arg Ala Gly Glu 
    210                 215                 220                 


Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His Asn Gly Asn Gly 
225                 230                 235                 240 


Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro Gln Asp Thr Ala 
                245                 250                 255     


Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala Gln Pro Leu Val 
            260                 265                 270         


Val Pro Trp Glu Ala Ser 
        275             


<210> 19
<211> 348
<212> PRT
<213> Homo sapiens

<400> 19
Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Pro Pro 
        195                 200                 205             


Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg 
    210                 215                 220                 


Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu 
225                 230                 235                 240 


Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val 
                245                 250                 255     


Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val 
            260                 265                 270         


Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly 
        275                 280                 285             


Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr 
    290                 295                 300                 


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
305                 310                 315                 320 


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
                325                 330                 335     


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
            340                 345             


<210> 20
<211> 326
<212> PRT
<213> Homo sapiens

<400> 20
Arg Leu Leu Arg Ser His Ser Leu His Tyr Leu Phe Met Gly Ala Ser 
1               5                   10                  15      


Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu Ala Leu Gly Tyr Val Asp 
            20                  25                  30          


Asp Gln Leu Phe Val Phe Tyr Asp His Glu Ser Arg Arg Val Glu Pro 
        35                  40                  45              


Arg Thr Pro Trp Val Ser Ser Arg Ile Ser Ser Gln Met Trp Leu Gln 
    50                  55                  60                  


Leu Ser Gln Ser Leu Lys Gly Trp Asp His Met Phe Thr Val Asp Phe 
65                  70                  75                  80  


Trp Thr Ile Met Glu Asn His Asn His Ser Lys Glu Ser His Thr Leu 
                85                  90                  95      


Gln Val Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly 
            100                 105                 110         


Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro 
        115                 120                 125             


Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys 
    130                 135                 140                 


Leu Glu Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr 
145                 150                 155                 160 


Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly 
                165                 170                 175     


Arg Gly Val Leu Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His 
            180                 185                 190         


His Val Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr 
        195                 200                 205             


Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met 
    210                 215                 220                 


Asp Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly 
225                 230                 235                 240 


Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile 
            260                 265                 270         


Val Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile 
        275                 280                 285             


Ser Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe 
    290                 295                 300                 


Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr 
305                 310                 315                 320 


Val Leu Ala Glu Arg Glu 
                325     


<210> 21
<211> 341
<212> PRT
<213> Homo sapiens

<400> 21
Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Pro Pro Leu Val Arg Val 
        195                 200                 205             


Asn Arg Lys Glu Thr Phe Pro Gly Val Thr Ala Leu Phe Cys Lys Ala 
    210                 215                 220                 


His Gly Phe Tyr Pro Pro Glu Ile Tyr Met Thr Trp Met Lys Asn Gly 
225                 230                 235                 240 


Glu Glu Ile Val Gln Glu Ile Asp Tyr Gly Asp Ile Leu Pro Ser Gly 
                245                 250                 255     


Asp Gly Thr Tyr Gln Ala Trp Ala Ser Ile Glu Leu Asp Pro Gln Ser 
            260                 265                 270         


Ser Asn Leu Tyr Ser Cys His Val Glu His Cys Gly Val His Met Val 
        275                 280                 285             


Leu Gln Val Pro Gln Glu Ser Glu Thr Ile Pro Leu Val Met Lys Ala 
    290                 295                 300                 


Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala Gly Val Gly Val 
305                 310                 315                 320 


Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly Ala Ile Tyr Leu 
                325                 330                 335     


Pro Thr Pro Asp Arg 
            340     


<210> 22
<211> 319
<212> PRT
<213> Homo sapiens

<400> 22
Arg Thr His Ser Leu Arg Tyr Phe Arg Leu Gly Val Ser Asp Pro Ile 
1               5                   10                  15      


His Gly Val Pro Glu Phe Ile Ser Val Gly Tyr Val Asp Ser His Pro 
            20                  25                  30          


Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln Lys Glu Pro Arg Ala Pro 
        35                  40                  45              


Trp Met Ala Glu Asn Leu Ala Pro Asp His Trp Glu Arg Tyr Thr Gln 
    50                  55                  60                  


Leu Leu Arg Gly Trp Gln Gln Met Phe Lys Val Glu Leu Lys Arg Leu 
65                  70                  75                  80  


Gln Arg His Tyr Asn His Ser Gly Ser His Thr Tyr Gln Arg Met Ile 
                85                  90                  95      


Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr Thr Gly Phe Leu Gln Tyr 
            100                 105                 110         


Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe Asn Lys Asp Thr Leu Ser 
        115                 120                 125             


Trp Leu Ala Val Asp Asn Val Ala His Thr Ile Lys Gln Ala Trp Glu 
    130                 135                 140                 


Ala Asn Gln His Glu Leu Leu Tyr Gln Lys Asn Trp Leu Glu Glu Glu 
145                 150                 155                 160 


Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu Tyr Gly Lys Asp Thr Leu 
                165                 170                 175     


Gln Arg Thr Glu Pro Pro Leu Val Arg Val Asn Arg Lys Glu Thr Phe 
            180                 185                 190         


Pro Gly Val Thr Ala Leu Phe Cys Lys Ala His Gly Phe Tyr Pro Pro 
        195                 200                 205             


Glu Ile Tyr Met Thr Trp Met Lys Asn Gly Glu Glu Ile Val Gln Glu 
    210                 215                 220                 


Ile Asp Tyr Gly Asp Ile Leu Pro Ser Gly Asp Gly Thr Tyr Gln Ala 
225                 230                 235                 240 


Trp Ala Ser Ile Glu Leu Asp Pro Gln Ser Ser Asn Leu Tyr Ser Cys 
                245                 250                 255     


His Val Glu His Cys Gly Val His Met Val Leu Gln Val Pro Gln Glu 
            260                 265                 270         


Ser Glu Thr Ile Pro Leu Val Met Lys Ala Val Ser Gly Ser Ile Val 
        275                 280                 285             


Leu Val Ile Val Leu Ala Gly Val Gly Val Leu Val Trp Arg Arg Arg 
    290                 295                 300                 


Pro Arg Glu Gln Asn Gly Ala Ile Tyr Leu Pro Thr Pro Asp Arg 
305                 310                 315                 


<210> 23
<211> 327
<212> PRT
<213> Homo sapiens

<400> 23
Met Leu Phe Leu Leu Leu Pro Leu Leu Ala Val Leu Pro Gly Asp Gly 
1               5                   10                  15      


Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
            20                  25                  30          


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
        35                  40                  45              


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
    50                  55                  60                  


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
65                  70                  75                  80  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
                85                  90                  95      


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
            100                 105                 110         


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
        115                 120                 125             


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
    130                 135                 140                 


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
145                 150                 155                 160 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
                165                 170                 175     


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
            180                 185                 190         


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
        195                 200                 205             


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
    210                 215                 220                 


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
225                 230                 235                 240 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
                245                 250                 255     


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
            260                 265                 270         


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
        275                 280                 285             


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
    290                 295                 300                 


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
305                 310                 315                 320 


Phe Arg Lys Arg Cys Phe Cys 
                325         


<210> 24
<211> 309
<212> PRT
<213> Homo sapiens

<400> 24
Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile Ala Ser 
1               5                   10                  15      


Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp Leu Ser 
            20                  25                  30          


Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile Val Phe 
        35                  40                  45              


Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp Lys Glu 
    50                  55                  60                  


Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu Gly Ile 
65                  70                  75                  80  


Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu Ile Gln 
                85                  90                  95      


Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly Ser Phe 
            100                 105                 110         


Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln Asn Asn 
        115                 120                 125             


Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His Phe Cys 
    130                 135                 140                 


Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His Asn Leu 
145                 150                 155                 160 


Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp Ala Gly 
                165                 170                 175     


Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu Ser His 
            180                 185                 190         


Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His Val Ser 
        195                 200                 205             


Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln 
    210                 215                 220                 


Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala Asp Gly 
225                 230                 235                 240 


Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu Ala Ala 
                245                 250                 255     


Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln Asp Ile 
            260                 265                 270         


Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile Leu Ala 
        275                 280                 285             


Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp Phe Arg 
    290                 295                 300                 


Lys Arg Cys Phe Cys 
305                 


<210> 25
<211> 333
<212> PRT
<213> Homo sapiens

<400> 25
Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln 
            20                  25                  30          


Thr Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr 
    50                  55                  60                  


Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu 
65                  70                  75                  80  


Val Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala 
                85                  90                  95      


Arg Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe 
            100                 105                 110         


Glu Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile 
        115                 120                 125             


Val Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val 
    130                 135                 140                 


Lys Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln 
145                 150                 155                 160 


Lys Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val 
                165                 170                 175     


Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu 
            180                 185                 190         


Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp 
        195                 200                 205             


Leu Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile 
    290                 295                 300                 


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Leu Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
                325                 330             


<210> 26
<211> 316
<212> PRT
<213> Homo sapiens

<400> 26
Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln Thr 
1               5                   10                  15      


Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly Trp 
            20                  25                  30          


Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr Ala 
        35                  40                  45              


Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu Val 
    50                  55                  60                  


Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala Arg 
65                  70                  75                  80  


Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe Glu 
                85                  90                  95      


Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile Val 
            100                 105                 110         


Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val Lys 
        115                 120                 125             


Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln Lys 
    130                 135                 140                 


Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val Arg 
145                 150                 155                 160 


Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu Asn 
                165                 170                 175     


Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
            180                 185                 190         


Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His 
        195                 200                 205             


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
    210                 215                 220                 


Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn Ala 
225                 230                 235                 240 


Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly Glu 
                245                 250                 255     


Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
            260                 265                 270         


Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile Val 
        275                 280                 285             


Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala Leu 
    290                 295                 300                 


Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
305                 310                 315     


<210> 27
<211> 333
<212> PRT
<213> Homo sapiens

<400> 27
Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210> 28
<211> 316
<212> PRT
<213> Homo sapiens

<400> 28
Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln Ile 
1               5                   10                  15      


Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly Trp 
            20                  25                  30          


Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr Ile 
        35                  40                  45              


Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu Leu 
    50                  55                  60                  


Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr Arg 
65                  70                  75                  80  


Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe Glu 
                85                  90                  95      


Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro Glu 
            100                 105                 110         


Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe Gln 
        115                 120                 125             


Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln Ser 
    130                 135                 140                 


Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr Val 
145                 150                 155                 160 


Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu Leu 
                165                 170                 175     


Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala Trp 
            180                 185                 190         


Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val Cys 
        195                 200                 205             


His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met Arg 
    210                 215                 220                 


Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro Asn 
225                 230                 235                 240 


Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser Glu 
                245                 250                 255     


Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly Gly 
            260                 265                 270         


Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp Ile 
        275                 280                 285             


Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val Leu 
    290                 295                 300                 


Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
305                 310                 315     


<210> 29
<211> 335
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210> 30
<211> 316
<212> PRT
<213> Homo sapiens

<400> 30
Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln Ile Ser Ser 
1               5                   10                  15      


Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala Trp Leu Gly 
            20                  25                  30          


Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr Val Arg Ser 
        35                  40                  45              


Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln Trp Glu Thr 
    50                  55                  60                  


Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr Arg Asp Val 
65                  70                  75                  80  


Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu Glu Leu Gln 
                85                  90                  95      


Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser Asn Asn Phe 
            100                 105                 110         


Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe Gln Gly Thr 
        115                 120                 125             


Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn Leu Ala Ile 
    130                 135                 140                 


Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val Gln Trp Leu 
145                 150                 155                 160 


Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu Glu Ser Gly 
                165                 170                 175     


Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp Leu Ser Arg 
            180                 185                 190         


Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys His Val Ser 
        195                 200                 205             


Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg Gly Glu Gln 
    210                 215                 220                 


Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn Ala Asp Glu 
225                 230                 235                 240 


Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly Glu Ala Ala 
                245                 250                 255     


Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln Asp Ile 
            260                 265                 270         


Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu Ile Ala Leu 
        275                 280                 285             


Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly Phe Thr Ser 
    290                 295                 300                 


Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
305                 310                 315     


<210> 31
<211> 388
<212> PRT
<213> Homo sapiens

<400> 31
Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210> 32
<211> 369
<212> PRT
<213> Homo sapiens

<400> 32
Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu Glu Gln Leu 
1               5                   10                  15      


Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His Ser Trp Ala 
            20                  25                  30          


His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr His Gly Trp 
        35                  40                  45              


Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp Ser His Gly 
    50                  55                  60                  


Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu Phe Gln Leu 
65                  70                  75                  80  


Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala Gly Gln Phe 
                85                  90                  95      


Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly Cys Arg Met 
            100                 105                 110         


Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly Ser Asp Phe 
        115                 120                 125             


Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly Ala Gly Ile 
    130                 135                 140                 


Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu Asp Ile Lys 
145                 150                 155                 160 


Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg Phe Leu Ala 
                165                 170                 175     


Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys Val Lys Pro 
            180                 185                 190         


Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln 
        195                 200                 205             


Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met 
    210                 215                 220                 


Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg Gly Asp Val 
225                 230                 235                 240 


Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val 
                245                 250                 255     


Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser 
            260                 265                 270         


Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr Ser Ile Phe 
        275                 280                 285             


Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val 
    290                 295                 300                 


Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys Asn Ile Leu 
305                 310                 315                 320 


Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
                325                 330                 335     


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
            340                 345                 350         


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
        355                 360                 365             


Trp 
    


<210> 33
<211> 11
<212> PRT
<213> Homo sapiens

<400> 33
Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
1               5                   10      


<210> 34
<211> 11
<212> PRT
<213> Homo sapiens

<400> 34
Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe 
1               5                   10      


<210> 35
<211> 11
<212> PRT
<213> Homo sapiens

<400> 35
Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
1               5                   10      


<210> 36
<211> 11
<212> PRT
<213> Homo sapiens

<400> 36
Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
1               5                   10      


<210> 37
<211> 8
<212> PRT
<213> Homo sapiens

<400> 37
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 38
<211> 8
<212> PRT
<213> Homo sapiens

<400> 38
Pro Thr Pro Ala Ser Ile Pro Leu 
1               5               


<210> 39
<211> 14
<212> PRT
<213> Homo sapiens

<400> 39
Pro Gln Leu Thr Ser Ser Glu Leu Met Ala Ile Thr Arg Lys 
1               5                   10                  


<210> 40
<211> 11
<212> PRT
<213> Homo sapiens

<400> 40
His Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10      


<210> 41
<211> 42
<212> PRT
<213> Homo sapiens

<400> 41
Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His 
1               5                   10                  15      


Lys Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln 
            20                  25                  30          


Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
        35                  40          


<210> 42
<211> 9
<212> PRT
<213> Homo sapiens

<400> 42
Ile Gln Arg Thr Pro Lys Ile Gln Val 
1               5                   


<210> 43
<211> 13
<212> PRT
<213> Homo sapiens

<400> 43
Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
1               5                   10              


<210> 44
<211> 23
<212> PRT
<213> Homo sapiens

<400> 44
Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser 
1               5                   10                  15      


Lys Asp Trp Ser Phe Tyr Leu 
            20              


<210> 45
<211> 16
<212> PRT
<213> Homo sapiens

<400> 45
Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
1               5                   10                  15      


<210> 46
<211> 365
<212> PRT
<213> Homo sapiens

<400> 46
Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210> 47
<211> 335
<212> PRT
<213> Homo sapiens

<400> 47
Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210> 48
<211> 388
<212> PRT
<213> Homo sapiens

<400> 48
Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210> 49
<211> 333
<212> PRT
<213> Homo sapiens

<400> 49
Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210> 50
<211> 327
<212> PRT
<213> Homo sapiens

<400> 50
Met Leu Phe Leu Leu Leu Pro Leu Leu Ala Val Leu Pro Gly Asp Gly 
1               5                   10                  15      


Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
            20                  25                  30          


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
        35                  40                  45              


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
    50                  55                  60                  


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
65                  70                  75                  80  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
                85                  90                  95      


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
            100                 105                 110         


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
        115                 120                 125             


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
    130                 135                 140                 


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
145                 150                 155                 160 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
                165                 170                 175     


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
            180                 185                 190         


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
        195                 200                 205             


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
    210                 215                 220                 


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
225                 230                 235                 240 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
                245                 250                 255     


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
            260                 265                 270         


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
        275                 280                 285             


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
    290                 295                 300                 


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
305                 310                 315                 320 


Phe Arg Lys Arg Cys Phe Cys 
                325         


<210> 51
<211> 333
<212> PRT
<213> Homo sapiens

<400> 51
Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln 
            20                  25                  30          


Thr Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr 
    50                  55                  60                  


Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu 
65                  70                  75                  80  


Val Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala 
                85                  90                  95      


Arg Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe 
            100                 105                 110         


Glu Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile 
        115                 120                 125             


Val Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val 
    130                 135                 140                 


Lys Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln 
145                 150                 155                 160 


Lys Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val 
                165                 170                 175     


Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu 
            180                 185                 190         


Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp 
        195                 200                 205             


Leu Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile 
    290                 295                 300                 


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Leu Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
                325                 330             


<210> 52
<211> 298
<212> PRT
<213> Homo sapiens

<400> 52
Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210> 53
<211> 309
<212> PRT
<213> Homo sapiens

<400> 53
Ser His Ser Leu His Tyr Leu Phe Met Gly Ala Ser Glu Gln Asp Leu 
1               5                   10                  15      


Gly Leu Ser Leu Phe Glu Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe 
            20                  25                  30          


Val Phe Tyr Asp Asp Glu Ser Arg Arg Val Glu Pro Arg Thr Pro Trp 
        35                  40                  45              


Val Ser Ser Arg Ile Ser Ser Gln Met Trp Leu Gln Leu Ser Gln Ser 
    50                  55                  60                  


Leu Lys Gly Trp Asp His Met Phe Thr Val Asp Phe Trp Thr Ile Met 
65                  70                  75                  80  


Glu Asn His Asn His Ser Lys Glu Ser His Thr Leu Gln Val Ile Leu 
                85                  90                  95      


Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr 
            100                 105                 110         


Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp Thr Leu Asp 
        115                 120                 125             


Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu 
    130                 135                 140                 


Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp 
145                 150                 155                 160 


Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly Val Leu 
                165                 170                 175     


Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His His Val Thr Ser 
            180                 185                 190         


Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn 
        195                 200                 205             


Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu 
    210                 215                 220                 


Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly 
225                 230                 235                 240 


Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Tyr 
                245                 250                 255     


Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu 
            260                 265                 270         


Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala 
        275                 280                 285             


Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg 
    290                 295                 300                 


Lys Arg Gln Gly Ser 
305                 


<210> 54
<211> 334
<212> PRT
<213> Homo sapiens

<400> 54
Leu Leu Pro Leu Ile Ile Val Leu Met Val Lys His Ser Asp Ser Arg 
1               5                   10                  15      


Thr His Ser Leu Arg Tyr Phe Arg Leu Gly Val Ser Asp Pro Ile His 
            20                  25                  30          


Gly Val Pro Glu Phe Ile Ser Val Gly Tyr Val Asp Ser His Pro Ile 
        35                  40                  45              


Thr Thr Tyr Asp Ser Val Thr Arg Gln Lys Glu Pro Arg Ala Pro Trp 
    50                  55                  60                  


Met Ala Glu Asn Leu Ala Pro Asp His Trp Glu Arg Tyr Thr Gln Leu 
65                  70                  75                  80  


Leu Arg Gly Trp Gln Gln Met Phe Lys Val Glu Leu Lys Arg Leu Gln 
                85                  90                  95      


Arg His Tyr Asn His Ser Gly Ser His Thr Tyr Gln Arg Met Ile Gly 
            100                 105                 110         


Cys Glu Leu Leu Glu Asp Gly Ser Thr Thr Gly Phe Leu Gln Tyr Ala 
        115                 120                 125             


Tyr Asp Gly Gln Asp Phe Leu Ile Phe Asn Lys Asp Thr Leu Ser Trp 
    130                 135                 140                 


Leu Ala Val Asp Asn Val Ala His Thr Ile Lys Gln Ala Trp Glu Ala 
145                 150                 155                 160 


Asn Gln His Glu Leu Leu Tyr Gln Lys Asn Trp Leu Glu Glu Glu Cys 
                165                 170                 175     


Ile Ala Trp Leu Lys Arg Phe Leu Glu Tyr Gly Lys Asp Thr Leu Gln 
            180                 185                 190         


Arg Thr Glu Pro Pro Leu Val Arg Val Asn Arg Lys Glu Thr Phe Pro 
        195                 200                 205             


Gly Val Thr Ala Leu Phe Cys Lys Ala His Gly Phe Tyr Pro Pro Glu 
    210                 215                 220                 


Ile Tyr Met Thr Trp Met Lys Asn Gly Glu Glu Ile Val Gln Glu Ile 
225                 230                 235                 240 


Asp Tyr Gly Asp Ile Leu Pro Ser Gly Asp Gly Thr Tyr Gln Ala Trp 
                245                 250                 255     


Ala Ser Ile Glu Leu Asp Pro Gln Ser Ser Asn Leu Tyr Ser Cys His 
            260                 265                 270         


Val Glu His Cys Gly Val His Met Val Leu Gln Val Pro Gln Glu Ser 
        275                 280                 285             


Glu Thr Ile Pro Leu Val Met Lys Ala Val Ser Gly Ser Ile Val Leu 
    290                 295                 300                 


Val Ile Val Leu Ala Gly Val Gly Val Leu Val Trp Arg Arg Arg Pro 
305                 310                 315                 320 


Arg Glu Gln Asn Gly Ala Ile Tyr Leu Pro Thr Pro Asp Arg 
                325                 330                 


<210> 55
<211> 358
<212> PRT
<213> Homo sapiens

<400> 55
Met Val Asp Gly Thr Leu Leu Leu Leu Ser Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210> 56
<211> 362
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val Thr Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Gly Val Ser Leu Thr Ala Asn Lys Val 
        355                 360         


<210> 57
<211> 280
<212> PRT
<213> Homo sapiens

<400> 57
Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Cys Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg 
        275                 280 


<210> 58
<211> 273
<212> PRT
<213> Homo sapiens

<400> 58
Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg 
    50                  55                  60                  


Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp 
                85                  90                  95      


Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg 
    130                 135                 140                 


Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg 
            260                 265                 270         


Trp 
    


<210> 59
<211> 362
<212> PRT
<213> Homo sapiens

<400> 59
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Thr Ser Pro Arg Lys Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Ser Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Tyr Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Trp Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asn Gln Leu Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Asp Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Ser Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210> 60
<211> 366
<212> PRT
<213> Homo sapiens

<400> 60
Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210> 61
<211> 28
<212> PRT
<213> Homo sapiens

<400> 61
Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
1               5                   10                  15      


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys 
            20                  25              


<210> 62
<211> 28
<212> PRT
<213> Homo sapiens

<400> 62
Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
1               5                   10                  15      


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys 
            20                  25              


<210> 63
<211> 28
<212> PRT
<213> Homo sapiens

<400> 63
Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
1               5                   10                  15      


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys 
            20                  25              


<210> 64
<211> 28
<212> PRT
<213> Homo sapiens

<400> 64
Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
1               5                   10                  15      


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg 
            20                  25              


<210> 65
<211> 28
<212> PRT
<213> Homo sapiens

<400> 65
Ala Ser Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
1               5                   10                  15      


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys 
            20                  25              


<210> 66
<211> 29
<212> PRT
<213> Homo sapiens

<400> 66
Glu Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile 
1               5                   10                  15      


Ser Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys 
            20                  25                  


<210> 67
<211> 28
<212> PRT
<213> Homo sapiens

<400> 67
Thr Arg Gln Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala 
1               5                   10                  15      


Pro Asp His Trp Glu Arg Tyr Thr Gln Leu Leu Arg 
            20                  25              


<210> 68
<211> 28
<212> PRT
<213> Homo sapiens

<400> 68
Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
1               5                   10                  15      


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala 
            20                  25              


<210> 69
<211> 31
<212> PRT
<213> Homo sapiens

<400> 69
Asp Ser Asn Ser Ser Thr Ile Val Phe Leu Trp Pro Trp Ser Arg Gly 
1               5                   10                  15      


Asn Phe Ser Asn Glu Glu Trp Lys Glu Leu Glu Thr Leu Phe Arg 
            20                  25                  30      


<210> 70
<211> 31
<212> PRT
<213> Homo sapiens

<400> 70
Asp Ser Asp Ser Gly Thr Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly 
1               5                   10                  15      


Asn Phe Ser Asp Lys Glu Val Ala Glu Leu Glu Glu Ile Phe Arg 
            20                  25                  30      


<210> 71
<211> 27
<212> PRT
<213> Homo sapiens

<400> 71
Asp Thr Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp 
1               5                   10                  15      


Gln Gln Trp Glu Thr Leu Gln His Ile Phe Arg 
            20                  25          


<210> 72
<211> 28
<212> PRT
<213> Homo sapiens

<400> 72
Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu Arg 
1               5                   10                  15      


Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg 
            20                  25              


<210> 73
<211> 39
<212> PRT
<213> Homo sapiens

<400> 73
Thr Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala 
1               5                   10                  15      


Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn 
            20                  25                  30          


Gly Lys Glu Thr Leu Gln Arg 
        35                  


<210> 74
<211> 29
<212> PRT
<213> Homo sapiens

<400> 74
Glu Gln Leu Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu Arg 
1               5                   10                  15      


Arg Tyr Leu Lys Asn Gly Lys Glu Thr Leu Gln Arg Ala 
            20                  25                  


<210> 75
<211> 28
<212> PRT
<213> Homo sapiens

<400> 75
Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His 
1               5                   10                  15      


Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His 
            20                  25              


<210> 76
<211> 28
<212> PRT
<213> Homo sapiens

<400> 76
Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His 
1               5                   10                  15      


Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg 
            20                  25              


<210> 77
<211> 31
<212> PRT
<213> Homo sapiens

<400> 77
Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala 
1               5                   10                  15      


Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln 
            20                  25                  30      


<210> 78
<211> 33
<212> PRT
<213> Homo sapiens

<400> 78
His Glu Leu Leu Tyr Gln Lys Asn Trp Leu Glu Glu Glu Cys Ile Ala 
1               5                   10                  15      


Trp Leu Lys Arg Phe Leu Glu Tyr Gly Lys Asp Thr Leu Gln Arg Thr 
            20                  25                  30          


Glu 
    


<210> 79
<211> 32
<212> PRT
<213> Homo sapiens

<400> 79
Pro Val Tyr Val Gln Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro 
1               5                   10                  15      


Ala Thr Leu Arg Lys Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg 
            20                  25                  30          


<210> 80
<211> 33
<212> PRT
<213> Homo sapiens

<400> 80
His Glu Asn Asp Ile Thr His Asn Leu Leu Ser Asp Thr Cys Pro Arg 
1               5                   10                  15      


Phe Ile Leu Gly Leu Leu Asp Ala Gly Lys Ala His Leu Gln Arg Gln 
            20                  25                  30          


Val 
    


<210> 81
<211> 30
<212> PRT
<213> Homo sapiens

<400> 81
Glu Thr Val Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu 
1               5                   10                  15      


Gly Val Leu Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val 
            20                  25                  30  


<210> 82
<211> 32
<212> PRT
<213> Homo sapiens

<400> 82
Trp Thr Arg Glu Thr Val Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln 
1               5                   10                  15      


Phe Val Ser Gly Leu Leu Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln 
            20                  25                  30          


<210> 83
<211> 6
<212> PRT
<213> Homo sapiens

<400> 83
Pro Thr Pro Ala Ser Ile 
1               5       


<210> 84
<211> 8
<212> PRT
<213> Homo sapiens

<400> 84
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 85
<211> 8
<212> PRT
<213> Homo sapiens

<400> 85
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 86
<211> 7
<212> PRT
<213> Homo sapiens

<400> 86
Pro Thr Pro Ala Ser Ile Pro 
1               5           


<210> 87
<211> 8
<212> PRT
<213> Homo sapiens

<400> 87
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 88
<211> 5
<212> PRT
<213> Homo sapiens

<400> 88
Pro Thr Pro Ala Ser 
1               5   


<210> 89
<211> 8
<212> PRT
<213> Homo sapiens

<400> 89
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 90
<211> 5
<212> PRT
<213> Homo sapiens

<400> 90
Pro Thr Pro Ala Ser 
1               5   


<210> 91
<211> 11
<212> PRT
<213> Homo sapiens

<400> 91
Leu Glu Lys Tyr Gly His Ser Asp Cys Cys Ser 
1               5                   10      


<210> 92
<211> 7
<212> PRT
<213> Homo sapiens

<400> 92
Pro Thr Pro Ala Ser Ile Pro 
1               5           


<210> 93
<211> 8
<212> PRT
<213> Homo sapiens

<400> 93
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 94
<211> 8
<212> PRT
<213> Homo sapiens

<400> 94
Lys Pro Thr Pro Ala Ser Ile Pro 
1               5               


<210> 95
<211> 8
<212> PRT
<213> Homo sapiens

<400> 95
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 96
<211> 7
<212> PRT
<213> Homo sapiens

<400> 96
Pro Thr Pro Ala Ser Ile Pro 
1               5           


<210> 97
<211> 8
<212> PRT
<213> Homo sapiens

<400> 97
Leu Glu Lys Tyr Gly His Ser Asp 
1               5               


<210> 98
<211> 7
<212> PRT
<213> Homo sapiens

<400> 98
Pro Thr Pro Ala Ser Ile Pro 
1               5           


<210> 99
<211> 10
<212> PRT
<213> Homo sapiens

<400> 99
Pro Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   10  


<210> 100
<211> 7
<212> PRT
<213> Homo sapiens

<400> 100
Pro Gln Leu Thr Ser Ser Glu 
1               5           


<210> 101
<211> 7
<212> PRT
<213> Homo sapiens

<400> 101
Pro Gln Leu Thr Ser Ser Glu 
1               5           


<210> 102
<211> 7
<212> PRT
<213> Homo sapiens

<400> 102
Pro Gln Leu Thr Ser Ser Glu 
1               5           


<210> 103
<211> 10
<212> PRT
<213> Homo sapiens

<400> 103
Pro Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   10  


<210> 104
<211> 10
<212> PRT
<213> Homo sapiens

<400> 104
Pro Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   10  


<210> 105
<211> 9
<212> PRT
<213> Homo sapiens

<400> 105
Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   


<210> 106
<211> 7
<212> PRT
<213> Homo sapiens

<400> 106
Pro Gln Leu Thr Ser Ser Glu 
1               5           


<210> 107
<211> 9
<212> PRT
<213> Homo sapiens

<400> 107
Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   


<210> 108
<211> 10
<212> PRT
<213> Homo sapiens

<400> 108
Pro Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   10  


<210> 109
<211> 9
<212> PRT
<213> Homo sapiens

<400> 109
Gln Leu Thr Ser Ser Glu Leu Met Ala 
1               5                   


<210> 110
<211> 10
<212> PRT
<213> Homo sapiens

<400> 110
Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10  


<210> 111
<211> 10
<212> PRT
<213> Homo sapiens

<400> 111
Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10  


<210> 112
<211> 11
<212> PRT
<213> Homo sapiens

<400> 112
His Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10      


<210> 113
<211> 7
<212> PRT
<213> Homo sapiens

<400> 113
Arg His Glu Met Thr Pro Val 
1               5           


<210> 114
<211> 11
<212> PRT
<213> Homo sapiens

<400> 114
His Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10      


<210> 115
<211> 9
<212> PRT
<213> Homo sapiens

<400> 115
Arg His Glu Met Thr Pro Val Asn Pro 
1               5                   


<210> 116
<211> 12
<212> PRT
<213> Homo sapiens

<400> 116
Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro 
1               5                   10          


<210> 117
<211> 7
<212> PRT
<213> Homo sapiens

<400> 117
Arg His Glu Met Thr Pro Val 
1               5           


<210> 118
<211> 11
<212> PRT
<213> Homo sapiens

<400> 118
His Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10      


<210> 119
<211> 10
<212> PRT
<213> Homo sapiens

<400> 119
Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10  


<210> 120
<211> 11
<212> PRT
<213> Homo sapiens

<400> 120
His Leu Cys Ile Arg His Glu Met Thr Pro Val 
1               5                   10      


<210> 121
<211> 39
<212> PRT
<213> Homo sapiens

<400> 121
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 122
<211> 39
<212> PRT
<213> Homo sapiens

<400> 122
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 123
<211> 39
<212> PRT
<213> Homo sapiens

<400> 123
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 124
<211> 39
<212> PRT
<213> Homo sapiens

<400> 124
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 125
<211> 39
<212> PRT
<213> Homo sapiens

<400> 125
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 126
<211> 39
<212> PRT
<213> Homo sapiens

<400> 126
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 127
<211> 33
<212> PRT
<213> Homo sapiens

<400> 127
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe 
    


<210> 128
<211> 39
<212> PRT
<213> Homo sapiens

<400> 128
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe Leu Ile Asn Leu Val Lys 
        35                  


<210> 129
<211> 32
<212> PRT
<213> Homo sapiens

<400> 129
Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys Asp 
1               5                   10                  15      


Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu Phe 
            20                  25                  30          


<210> 130
<211> 33
<212> PRT
<213> Homo sapiens

<400> 130
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu 
            20                  25                  30          


Phe 
    


<210> 131
<211> 20
<212> PRT
<213> Homo sapiens

<400> 131
Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys Phe Ile Phe His Lys 
1               5                   10                  15      


Asp Leu Cys Gln 
            20  


