                         SEQUENCE LISTING

<110>  The Jackson Laboratory
       Cheng, Albert
       Taghbalout, Aziz
       Jillette, Nathaniel
 
<120>  Target DNA Demethylation and Methylation

<130>  52867-501001WO

<150>  US 62/393,944
<151>  2016-09-13

<150>  US 62/485,210
<151>  2017-04-13

<150>  US 62/535,113
<151>  2017-07-20

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  1
uguaugua                                                                 8


<210>  2
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  3
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  4
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  5
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  6
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  6
gttttagagc tagaaatagc aagttaaaat aaggcta                                37


<210>  7
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  7
gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggcta                     47


<210>  8
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  8
uguaugua                                                                 8


<210>  9
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  9
uugauaua                                                                 8


<210>  10
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  10
uguauaua                                                                 8


<210>  11
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  11
uggauaua                                                                 8


<210>  12
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  12
uuuauaua                                                                 8


<210>  13
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  13
ugugugug                                                                 8


<210>  14
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  14
uguauaug                                                                 8


<210>  15
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  15
uauauaua                                                                 8


<210>  16
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  16
uguauuua                                                                 8


<210>  17
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  17
uuuauuua                                                                 8


<210>  18
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  19
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  27
uugaugua                                                                 8


<210>  28
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Cys Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  29
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Cys Arg Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  30
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Cys Val Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  31
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Cys Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Cys Val Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Cys Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr 
            340     


<210>  32
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
1               5                   10                  15      


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
            20                  25                  30          


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
        35                  40                  45              


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
    50                  55                  60                  


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
65                  70                  75                  80  


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
                85                  90                  95      


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
            100                 105                 110         


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala 
        115                 120                 125             


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
    130                 135                 140                 


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
145                 150                 155                 160 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
                165                 170                 175     


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
            180                 185                 190         


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
        195                 200                 205             


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
    210                 215                 220                 


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
225                 230                 235                 240 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
                245                 250                 255     


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
            260                 265                 270         


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
        275                 280                 285             


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
    290                 295                 300                 


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
305                 310                 315                 320 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
                325                 330                 335     


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
            340                 345                 350         


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Pro Ala Gly Ser 
        355                 360                 365             


Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    370                 375                 380                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
385                 390                 395                 400 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
                405                 410                 415     


Asp Leu Asp Met Leu Tyr Ile Asp 
            420                 


<210>  33
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
1               5                   10                  15      


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
            20                  25                  30          


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
        35                  40                  45              


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
    50                  55                  60                  


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
65                  70                  75                  80  


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
                85                  90                  95      


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
            100                 105                 110         


Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala 
        115                 120                 125             


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
    130                 135                 140                 


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
145                 150                 155                 160 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
                165                 170                 175     


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
            180                 185                 190         


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
        195                 200                 205             


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
    210                 215                 220                 


Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly 
225                 230                 235                 240 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
                245                 250                 255     


Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys 
            260                 265                 270         


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
        275                 280                 285             


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
    290                 295                 300                 


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
305                 310                 315                 320 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
                325                 330                 335     


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
            340                 345                 350         


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Pro Ala Gly Ser 
        355                 360                 365             


Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    370                 375                 380                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
385                 390                 395                 400 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
                405                 410                 415     


Asp Leu Asp Met Leu Tyr Ile Asp 
            420                 


<210>  34
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
1               5                   10                  15      


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
            20                  25                  30          


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
        35                  40                  45              


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
    50                  55                  60                  


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
65                  70                  75                  80  


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
                85                  90                  95      


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
            100                 105                 110         


Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala 
        115                 120                 125             


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
    130                 135                 140                 


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
145                 150                 155                 160 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
                165                 170                 175     


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
            180                 185                 190         


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
        195                 200                 205             


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
    210                 215                 220                 


Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly 
225                 230                 235                 240 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
                245                 250                 255     


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
            260                 265                 270         


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
        275                 280                 285             


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
    290                 295                 300                 


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
305                 310                 315                 320 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
                325                 330                 335     


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
            340                 345                 350         


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Pro Ala Gly Ser 
        355                 360                 365             


Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    370                 375                 380                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
385                 390                 395                 400 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
                405                 410                 415     


Asp Leu Asp Met Leu Tyr Ile Asp 
            420                 


<210>  35
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg 
1               5                   10                  15      


Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln 
            20                  25                  30          


Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His 
        35                  40                  45              


Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
    50                  55                  60                  


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
65                  70                  75                  80  


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
                85                  90                  95      


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
            100                 105                 110         


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala 
        115                 120                 125             


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
    130                 135                 140                 


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val 
145                 150                 155                 160 


Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
                165                 170                 175     


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
            180                 185                 190         


Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
        195                 200                 205             


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
    210                 215                 220                 


Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly 
225                 230                 235                 240 


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
                245                 250                 255     


Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys 
            260                 265                 270         


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
        275                 280                 285             


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
    290                 295                 300                 


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
305                 310                 315                 320 


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
                325                 330                 335     


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
            340                 345                 350         


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Pro Ala Gly Ser 
        355                 360                 365             


Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    370                 375                 380                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
385                 390                 395                 400 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
                405                 410                 415     


Asp Leu Asp Met Leu Tyr Ile Asp 
            420                 


<210>  36
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  36
acagaggaga aagac                                                        15


<210>  37
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37
gcaaaccaac cg                                                           12


<210>  38
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38
gcccaaaaac gaaccaa                                                      17


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  39
aaacgaacca aaggaagag                                                    19


<210>  40
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  40
ccagcggcag caga                                                         14


<210>  41
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  41
gcaccgccca ggc                                                          13


<210>  42
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  42
gcgccagaca cccagcag                                                     18


<210>  43
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  43
gcagagcgga ggagggc                                                      17


<210>  44
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  44
gaaggaagaa cggagcacg                                                    19


<210>  45
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  45
ggcagagccg ccaggga                                                      17


<210>  46
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  46
gcgcaagcgc aaccc                                                        15


<210>  47
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  47
gcaggacggg ggcgc                                                        15


<210>  48
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  48
gcgccggggc agaa                                                         14


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  49
gccggccgcg cgggggaggc                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  50
ggcaggcgag gagggggagg                                                   20


<210>  51
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Glu Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp Lys 
1               5                   10                  15      


Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala Val 
            20                  25                  30          


Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile Arg 
        35                  40                  45              


Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His Gly 
    50                  55                  60                  


Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu Lys 
65                  70                  75                  80  


Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr Ala 
                85                  90                  95      


Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro Met 
            100                 105                 110         


Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr Asn 
        115                 120                 125             


Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr Cys 
    130                 135                 140                 


Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser Phe 
145                 150                 155                 160 


Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg Ser 
                165                 170                 175     


Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His Glu 
            180                 185                 190         


Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala Pro 
        195                 200                 205             


Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu Tyr 
    210                 215                 220                 


Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg Pro 
225                 230                 235                 240 


Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His Arg 
                245                 250                 255     


Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu Thr 
            260                 265                 270         


Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln Leu 
        275                 280                 285             


His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly Ser 
    290                 295                 300                 


Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val Leu 
305                 310                 315                 320 


Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro Arg 
                325                 330                 335     


Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His Lys 
            340                 345                 350         


Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys Asn 
        355                 360                 365             


Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr Leu 
    370                 375                 380                 


Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr Glu 
385                 390                 395                 400 


Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser Leu 
                405                 410                 415     


Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe Ser 
            420                 425                 430         


Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn Asp 
        435                 440                 445             


Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His Cys 
    450                 455                 460                 


Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr Leu 
                485                 490                 495     


Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr Gly 
            500                 505                 510         


Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser Phe 
        515                 520                 525             


Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp Glu 
    530                 535                 540                 


Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser Asp 
545                 550                 555                 560 


Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu Tyr 
                565                 570                 575     


Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly Val 
            580                 585                 590         


Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg Arg 
        595                 600                 605             


Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His Pro 
    610                 615                 620                 


Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys Pro 
625                 630                 635                 640 


Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu Ala 
                645                 650                 655     


Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala Asn 
            660                 665                 670         


Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile Pro 
        675                 680                 685             


Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val Ser 
    690                 695                 700                 


Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 


<210>  52
<211>  2157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Met Gly Pro Ala Glu Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile 
1               5                   10                  15      


Gln Lys Asp Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser 
            20                  25                  30          


Val Ala Ala Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly 
        35                  40                  45              


Asn Ala Ile Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys 
    50                  55                  60                  


Ser Ser His Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser 
65                  70                  75                  80  


Asp Glu Glu Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His 
                85                  90                  95      


Cys Pro Thr Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile 
            100                 105                 110         


Pro Leu Pro Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu 
        115                 120                 125             


Lys Ser Tyr Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu 
    130                 135                 140                 


Asn Arg Thr Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala 
145                 150                 155                 160 


Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys 
                165                 170                 175     


Phe Gly Arg Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser 
            180                 185                 190         


Pro Leu His Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr 
        195                 200                 205             


Arg Leu Ala Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn 
    210                 215                 220                 


Gln Val Glu Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys 
225                 230                 235                 240 


Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala 
                245                 250                 255     


His Pro His Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val 
            260                 265                 270         


Cys Thr Leu Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln 
        275                 280                 285             


Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp 
    290                 295                 300                 


Glu Phe Gly Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala 
305                 310                 315                 320 


Ile Glu Val Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln 
                325                 330                 335     


Pro Val Pro Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val 
            340                 345                 350         


Leu Ala His Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile 
        355                 360                 365             


Lys Arg Lys Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser 
    370                 375                 380                 


Leu Pro Thr Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys 
385                 390                 395                 400 


Ser Glu Thr Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys 
                405                 410                 415     


Thr Tyr Ser Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser 
            420                 425                 430         


Pro Gly Phe Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro 
        435                 440                 445             


Leu Lys Asn Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser 
    450                 455                 460                 


Thr Pro His Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala 
465                 470                 475                 480 


Ala Ala Ala Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro 
                485                 490                 495     


Leu Pro Thr Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu 
            500                 505                 510         


Pro Ser Thr Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His 
        515                 520                 525             


Gln Pro Ser Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met 
    530                 535                 540                 


Glu Glu Asp Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu 
545                 550                 555                 560 


Pro Leu Ser Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His 
                565                 570                 575     


Ile Asp Glu Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn 
            580                 585                 590         


Ile Gly Gly Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu 
        595                 600                 605             


Cys Ala Arg Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn 
    610                 615                 620                 


Arg Asn His Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn 
625                 630                 635                 640 


Leu Asn Lys Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu 
                645                 650                 655     


Ala Lys Glu Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp 
            660                 665                 670         


Gln Ala Ala Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu 
        675                 680                 685             


Asn Gln Ile Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val 
    690                 695                 700                 


Val Thr Val Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn 
705                 710                 715                 720 


His Trp Val Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                725                 730                 735     


Gly Gly Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro 
            740                 745                 750         


Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly 
        755                 760                 765             


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
    770                 775                 780                 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
785                 790                 795                 800 


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
                805                 810                 815     


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
            820                 825                 830         


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
        835                 840                 845             


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
    850                 855                 860                 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
865                 870                 875                 880 


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
                885                 890                 895     


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
            900                 905                 910         


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
        915                 920                 925             


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
    930                 935                 940                 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
945                 950                 955                 960 


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
                965                 970                 975     


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
            980                 985                 990         


Lys Lys Asn Gly Leu Phe Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu 
        995                 1000                 1005             


Thr Pro  Asn Phe Lys Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys 
    1010                 1015                 1020             


Leu Gln  Leu Ser Lys Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu 
    1025                 1030                 1035             


Leu Ala  Gln Ile Gly Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala 
    1040                 1045                 1050             


Lys Asn  Leu Ser Asp Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val 
    1055                 1060                 1065             


Asn Thr  Glu Ile Thr Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys 
    1070                 1075                 1080             


Arg Tyr  Asp Glu His His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu 
    1085                 1090                 1095             


Val Arg  Gln Gln Leu Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp 
    1100                 1105                 1110             


Gln Ser  Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
    1115                 1120                 1125             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1130                 1135                 1140             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1145                 1150                 1155             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1160                 1165                 1170             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1175                 1180                 1185             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1190                 1195                 1200             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1205                 1210                 1215             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1220                 1225                 1230             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1235                 1240                 1245             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1250                 1255                 1260             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1265                 1270                 1275             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1280                 1285                 1290             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1295                 1300                 1305             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1310                 1315                 1320             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1325                 1330                 1335             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1340                 1345                 1350             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1355                 1360                 1365             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1370                 1375                 1380             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1385                 1390                 1395             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1400                 1405                 1410             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1415                 1420                 1425             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1430                 1435                 1440             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1445                 1450                 1455             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1460                 1465                 1470             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1475                 1480                 1485             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1490                 1495                 1500             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1505                 1510                 1515             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1520                 1525                 1530             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1535                 1540                 1545             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1550                 1555                 1560             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1565                 1570                 1575             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1580                 1585                 1590             


Ser Asp  Tyr Asp Val Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys 
    1595                 1600                 1605             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1610                 1615                 1620             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1625                 1630                 1635             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1640                 1645                 1650             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1655                 1660                 1665             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1670                 1675                 1680             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1685                 1690                 1695             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1700                 1705                 1710             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1715                 1720                 1725             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1730                 1735                 1740             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1745                 1750                 1755             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1760                 1765                 1770             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1775                 1780                 1785             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1790                 1795                 1800             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1805                 1810                 1815             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1820                 1825                 1830             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1835                 1840                 1845             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1850                 1855                 1860             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1865                 1870                 1875             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1880                 1885                 1890             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1895                 1900                 1905             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1910                 1915                 1920             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1925                 1930                 1935             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    1940                 1945                 1950             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1955                 1960                 1965             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    1970                 1975                 1980             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    1985                 1990                 1995             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    2000                 2005                 2010             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    2015                 2020                 2025             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    2030                 2035                 2040             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    2045                 2050                 2055             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    2060                 2065                 2070             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    2075                 2080                 2085             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    2090                 2095                 2100             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    2105                 2110                 2115             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Ser Pro  Lys Lys Lys 
    2120                 2125                 2130             


Arg Lys  Val Glu Ala Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    2135                 2140                 2145             


Ser Gly  Gly Gly Gly Ser Gly  Pro Ala 
    2150                 2155         


<210>  53
<211>  2156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  53

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  Glu Leu Pro Thr Cys  Ser Cys Leu 
    1430                 1435                 1440             


Asp Arg  Val Ile Gln Lys Asp  Lys Gly Pro Tyr Tyr  Thr His Leu 
    1445                 1450                 1455             


Gly Ala  Gly Pro Ser Val Ala  Ala Val Arg Glu Ile  Met Glu Asn 
    1460                 1465                 1470             


Arg Tyr  Gly Gln Lys Gly Asn  Ala Ile Arg Ile Glu  Ile Val Val 
    1475                 1480                 1485             


Tyr Thr  Gly Lys Glu Gly Lys  Ser Ser His Gly Cys  Pro Ile Ala 
    1490                 1495                 1500             


Lys Trp  Val Leu Arg Arg Ser  Ser Asp Glu Glu Lys  Val Leu Cys 
    1505                 1510                 1515             


Leu Val  Arg Gln Arg Thr Gly  His His Cys Pro Thr  Ala Val Met 
    1520                 1525                 1530             


Val Val  Leu Ile Met Val Trp  Asp Gly Ile Pro Leu  Pro Met Ala 
    1535                 1540                 1545             


Asp Arg  Leu Tyr Thr Glu Leu  Thr Glu Asn Leu Lys  Ser Tyr Asn 
    1550                 1555                 1560             


Gly His  Pro Thr Asp Arg Arg  Cys Thr Leu Asn Glu  Asn Arg Thr 
    1565                 1570                 1575             


Cys Thr  Cys Gln Gly Ile Asp  Pro Glu Thr Cys Gly  Ala Ser Phe 
    1580                 1585                 1590             


Ser Phe  Gly Cys Ser Trp Ser  Met Tyr Phe Asn Gly  Cys Lys Phe 
    1595                 1600                 1605             


Gly Arg  Ser Pro Ser Pro Arg  Arg Phe Arg Ile Asp  Pro Ser Ser 
    1610                 1615                 1620             


Pro Leu  His Glu Lys Asn Leu  Glu Asp Asn Leu Gln  Ser Leu Ala 
    1625                 1630                 1635             


Thr Arg  Leu Ala Pro Ile Tyr  Lys Gln Tyr Ala Pro  Val Ala Tyr 
    1640                 1645                 1650             


Gln Asn  Gln Val Glu Tyr Glu  Asn Val Ala Arg Glu  Cys Arg Leu 
    1655                 1660                 1665             


Gly Ser  Lys Glu Gly Arg Pro  Phe Ser Gly Val Thr  Ala Cys Leu 
    1670                 1675                 1680             


Asp Phe  Cys Ala His Pro His  Arg Asp Ile His Asn  Met Asn Asn 
    1685                 1690                 1695             


Gly Ser  Thr Val Val Cys Thr  Leu Thr Arg Glu Asp  Asn Arg Ser 
    1700                 1705                 1710             


Leu Gly  Val Ile Pro Gln Asp  Glu Gln Leu His Val  Leu Pro Leu 
    1715                 1720                 1725             


Tyr Lys  Leu Ser Asp Thr Asp  Glu Phe Gly Ser Lys  Glu Gly Met 
    1730                 1735                 1740             


Glu Ala  Lys Ile Lys Ser Gly  Ala Ile Glu Val Leu  Ala Pro Arg 
    1745                 1750                 1755             


Arg Lys  Lys Arg Thr Cys Phe  Thr Gln Pro Val Pro  Arg Ser Gly 
    1760                 1765                 1770             


Lys Lys  Arg Ala Ala Met Met  Thr Glu Val Leu Ala  His Lys Ile 
    1775                 1780                 1785             


Arg Ala  Val Glu Lys Lys Pro  Ile Pro Arg Ile Lys  Arg Lys Asn 
    1790                 1795                 1800             


Asn Ser  Thr Thr Thr Asn Asn  Ser Lys Pro Ser Ser  Leu Pro Thr 
    1805                 1810                 1815             


Leu Gly  Ser Asn Thr Glu Thr  Val Gln Pro Glu Val  Lys Ser Glu 
    1820                 1825                 1830             


Thr Glu  Pro His Phe Ile Leu  Lys Ser Ser Asp Asn  Thr Lys Thr 
    1835                 1840                 1845             


Tyr Ser  Leu Met Pro Ser Ala  Pro His Pro Val Lys  Glu Ala Ser 
    1850                 1855                 1860             


Pro Gly  Phe Ser Trp Ser Pro  Lys Thr Ala Ser Ala  Thr Pro Ala 
    1865                 1870                 1875             


Pro Leu  Lys Asn Asp Ala Thr  Ala Ser Cys Gly Phe  Ser Glu Arg 
    1880                 1885                 1890             


Ser Ser  Thr Pro His Cys Thr  Met Pro Ser Gly Arg  Leu Ser Gly 
    1895                 1900                 1905             


Ala Asn  Ala Ala Ala Ala Asp  Gly Pro Gly Ile Ser  Gln Leu Gly 
    1910                 1915                 1920             


Glu Val  Ala Pro Leu Pro Thr  Leu Ser Ala Pro Val  Met Glu Pro 
    1925                 1930                 1935             


Leu Ile  Asn Ser Glu Pro Ser  Thr Gly Val Thr Glu  Pro Leu Thr 
    1940                 1945                 1950             


Pro His  Gln Pro Asn His Gln  Pro Ser Phe Leu Thr  Ser Pro Gln 
    1955                 1960                 1965             


Asp Leu  Ala Ser Ser Pro Met  Glu Glu Asp Glu Gln  His Ser Glu 
    1970                 1975                 1980             


Ala Asp  Glu Pro Pro Ser Asp  Glu Pro Leu Ser Asp  Asp Pro Leu 
    1985                 1990                 1995             


Ser Pro  Ala Glu Glu Lys Leu  Pro His Ile Asp Glu  Tyr Trp Ser 
    2000                 2005                 2010             


Asp Ser  Glu His Ile Phe Leu  Asp Ala Asn Ile Gly  Gly Val Ala 
    2015                 2020                 2025             


Ile Ala  Pro Ala His Gly Ser  Val Leu Ile Glu Cys  Ala Arg Arg 
    2030                 2035                 2040             


Glu Leu  His Ala Thr Thr Pro  Val Glu His Pro Asn  Arg Asn His 
    2045                 2050                 2055             


Pro Thr  Arg Leu Ser Leu Val  Phe Tyr Gln His Lys  Asn Leu Asn 
    2060                 2065                 2070             


Lys Pro  Gln His Gly Phe Glu  Leu Asn Lys Ile Lys  Phe Glu Ala 
    2075                 2080                 2085             


Lys Glu  Ala Lys Asn Lys Lys  Met Lys Ala Ser Glu  Gln Lys Asp 
    2090                 2095                 2100             


Gln Ala  Ala Asn Glu Gly Pro  Glu Gln Ser Ser Glu  Val Asn Glu 
    2105                 2110                 2115             


Leu Asn  Gln Ile Pro Ser His  Lys Ala Leu Thr Leu  Thr His Asp 
    2120                 2125                 2130             


Asn Val  Val Thr Val Ser Pro  Tyr Ala Leu Thr His  Val Ala Gly 
    2135                 2140                 2145             


Pro Tyr  Asn His Trp Val Ile  Asp 
    2150                 2155     


<210>  54
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Met Gly Pro Ala Glu Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile 
1               5                   10                  15      


Gln Lys Asp Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser 
            20                  25                  30          


Val Ala Ala Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly 
        35                  40                  45              


Asn Ala Ile Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys 
    50                  55                  60                  


Ser Ser His Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser 
65                  70                  75                  80  


Asp Glu Glu Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His 
                85                  90                  95      


Cys Pro Thr Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile 
            100                 105                 110         


Pro Leu Pro Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu 
        115                 120                 125             


Lys Ser Tyr Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu 
    130                 135                 140                 


Asn Arg Thr Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala 
145                 150                 155                 160 


Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys 
                165                 170                 175     


Phe Gly Arg Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser 
            180                 185                 190         


Pro Leu His Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr 
        195                 200                 205             


Arg Leu Ala Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn 
    210                 215                 220                 


Gln Val Glu Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys 
225                 230                 235                 240 


Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala 
                245                 250                 255     


His Pro His Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val 
            260                 265                 270         


Cys Thr Leu Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln 
        275                 280                 285             


Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp 
    290                 295                 300                 


Glu Phe Gly Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala 
305                 310                 315                 320 


Ile Glu Val Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln 
                325                 330                 335     


Pro Val Pro Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val 
            340                 345                 350         


Leu Ala His Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile 
        355                 360                 365             


Lys Arg Lys Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser 
    370                 375                 380                 


Leu Pro Thr Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys 
385                 390                 395                 400 


Ser Glu Thr Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys 
                405                 410                 415     


Thr Tyr Ser Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser 
            420                 425                 430         


Pro Gly Phe Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro 
        435                 440                 445             


Leu Lys Asn Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser 
    450                 455                 460                 


Thr Pro His Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala 
465                 470                 475                 480 


Ala Ala Ala Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro 
                485                 490                 495     


Leu Pro Thr Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu 
            500                 505                 510         


Pro Ser Thr Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His 
        515                 520                 525             


Gln Pro Ser Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met 
    530                 535                 540                 


Glu Glu Asp Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu 
545                 550                 555                 560 


Pro Leu Ser Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His 
                565                 570                 575     


Ile Asp Glu Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn 
            580                 585                 590         


Ile Gly Gly Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu 
        595                 600                 605             


Cys Ala Arg Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn 
    610                 615                 620                 


Arg Asn His Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn 
625                 630                 635                 640 


Leu Asn Lys Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu 
                645                 650                 655     


Ala Lys Glu Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp 
            660                 665                 670         


Gln Ala Ala Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu 
        675                 680                 685             


Asn Gln Ile Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val 
    690                 695                 700                 


Val Thr Val Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn 
705                 710                 715                 720 


His Trp Val Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg 
                725                 730                 735     


Lys Val Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg 
            740                 745                 750         


Lys Val Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly 
        755                 760                 765             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro 
    770                 775                 780                 


Pro Lys Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu 
785                 790                 795                 800 


Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala 
                805                 810                 815     


Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile 
            820                 825                 830         


Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe 
        835                 840                 845             


Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly 
    850                 855                 860                 


Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys 
865                 870                 875                 880 


Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu 
                885                 890                 895     


Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro 
            900                 905                 910         


Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu 
        915                 920                 925             


Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile 
    930                 935                 940                 


Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys 
945                 950                 955                 960 


Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile 
                965                 970                 975     


Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu 
            980                 985                 990         


Glu Glu Leu His Gln His Thr Glu  Gln Leu Val Gln Asp  Gln Tyr Gly 
        995                 1000                 1005             


Asn Tyr  Val Ile Gln His Val  Leu Glu His Gly Arg  Pro Glu Asp 
    1010                 1015                 1020             


Lys Ser  Lys Ile Val Ala Glu  Ile Arg Gly Asn Val  Leu Val Leu 
    1025                 1030                 1035             


Ser Gln  His Lys Phe Ala Ser  Asn Val Val Glu Lys  Cys Val Thr 
    1040                 1045                 1050             


His Ala  Ser Arg Thr Glu Arg  Ala Val Leu Ile Asp  Glu Val Cys 
    1055                 1060                 1065             


Thr Met  Asn Asp Gly Pro His  Ser Ala Leu Tyr Thr  Met Met Lys 
    1070                 1075                 1080             


Asp Gln  Tyr Ala Asn Tyr Val  Val Gln Lys Met Ile  Asp Val Ala 
    1085                 1090                 1095             


Glu Pro  Gly Gln Arg Lys Ile  Val Met His Lys Ile  Arg Pro His 
    1100                 1105                 1110             


Ile Ala  Thr Leu Arg Lys Tyr  Thr Tyr Gly Lys His  Ile Leu Ala 
    1115                 1120                 1125             


Lys Leu  Glu Lys Tyr Tyr Met  Lys Asn Gly Val Asp  Leu Gly Asp 
    1130                 1135                 1140             


Pro Lys  Lys Lys Arg Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val 
    1145                 1150                 1155             


Gly Gly  Arg Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1160                 1165                 1170             


Gly Gly  Ser Gly Pro Ala 
    1175                 


<210>  55
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Glu Leu Pro Thr Cys Ser Cys 
    450                 455                 460                 


Leu Asp Arg Val Ile Gln Lys Asp Lys Gly Pro Tyr Tyr Thr His Leu 
465                 470                 475                 480 


Gly Ala Gly Pro Ser Val Ala Ala Val Arg Glu Ile Met Glu Asn Arg 
                485                 490                 495     


Tyr Gly Gln Lys Gly Asn Ala Ile Arg Ile Glu Ile Val Val Tyr Thr 
            500                 505                 510         


Gly Lys Glu Gly Lys Ser Ser His Gly Cys Pro Ile Ala Lys Trp Val 
        515                 520                 525             


Leu Arg Arg Ser Ser Asp Glu Glu Lys Val Leu Cys Leu Val Arg Gln 
    530                 535                 540                 


Arg Thr Gly His His Cys Pro Thr Ala Val Met Val Val Leu Ile Met 
545                 550                 555                 560 


Val Trp Asp Gly Ile Pro Leu Pro Met Ala Asp Arg Leu Tyr Thr Glu 
                565                 570                 575     


Leu Thr Glu Asn Leu Lys Ser Tyr Asn Gly His Pro Thr Asp Arg Arg 
            580                 585                 590         


Cys Thr Leu Asn Glu Asn Arg Thr Cys Thr Cys Gln Gly Ile Asp Pro 
        595                 600                 605             


Glu Thr Cys Gly Ala Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr 
    610                 615                 620                 


Phe Asn Gly Cys Lys Phe Gly Arg Ser Pro Ser Pro Arg Arg Phe Arg 
625                 630                 635                 640 


Ile Asp Pro Ser Ser Pro Leu His Glu Lys Asn Leu Glu Asp Asn Leu 
                645                 650                 655     


Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile Tyr Lys Gln Tyr Ala Pro 
            660                 665                 670         


Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu Asn Val Ala Arg Glu Cys 
        675                 680                 685             


Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys 
    690                 695                 700                 


Leu Asp Phe Cys Ala His Pro His Arg Asp Ile His Asn Met Asn Asn 
705                 710                 715                 720 


Gly Ser Thr Val Val Cys Thr Leu Thr Arg Glu Asp Asn Arg Ser Leu 
                725                 730                 735     


Gly Val Ile Pro Gln Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys 
            740                 745                 750         


Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys Glu Gly Met Glu Ala Lys 
        755                 760                 765             


Ile Lys Ser Gly Ala Ile Glu Val Leu Ala Pro Arg Arg Lys Lys Arg 
    770                 775                 780                 


Thr Cys Phe Thr Gln Pro Val Pro Arg Ser Gly Lys Lys Arg Ala Ala 
785                 790                 795                 800 


Met Met Thr Glu Val Leu Ala His Lys Ile Arg Ala Val Glu Lys Lys 
                805                 810                 815     


Pro Ile Pro Arg Ile Lys Arg Lys Asn Asn Ser Thr Thr Thr Asn Asn 
            820                 825                 830         


Ser Lys Pro Ser Ser Leu Pro Thr Leu Gly Ser Asn Thr Glu Thr Val 
        835                 840                 845             


Gln Pro Glu Val Lys Ser Glu Thr Glu Pro His Phe Ile Leu Lys Ser 
    850                 855                 860                 


Ser Asp Asn Thr Lys Thr Tyr Ser Leu Met Pro Ser Ala Pro His Pro 
865                 870                 875                 880 


Val Lys Glu Ala Ser Pro Gly Phe Ser Trp Ser Pro Lys Thr Ala Ser 
                885                 890                 895     


Ala Thr Pro Ala Pro Leu Lys Asn Asp Ala Thr Ala Ser Cys Gly Phe 
            900                 905                 910         


Ser Glu Arg Ser Ser Thr Pro His Cys Thr Met Pro Ser Gly Arg Leu 
        915                 920                 925             


Ser Gly Ala Asn Ala Ala Ala Ala Asp Gly Pro Gly Ile Ser Gln Leu 
    930                 935                 940                 


Gly Glu Val Ala Pro Leu Pro Thr Leu Ser Ala Pro Val Met Glu Pro 
945                 950                 955                 960 


Leu Ile Asn Ser Glu Pro Ser Thr Gly Val Thr Glu Pro Leu Thr Pro 
                965                 970                 975     


His Gln Pro Asn His Gln Pro Ser Phe Leu Thr Ser Pro Gln Asp Leu 
            980                 985                 990         


Ala Ser Ser Pro Met Glu Glu Asp  Glu Gln His Ser Glu  Ala Asp Glu 
        995                 1000                 1005             


Pro Pro  Ser Asp Glu Pro Leu  Ser Asp Asp Pro Leu  Ser Pro Ala 
    1010                 1015                 1020             


Glu Glu  Lys Leu Pro His Ile  Asp Glu Tyr Trp Ser  Asp Ser Glu 
    1025                 1030                 1035             


His Ile  Phe Leu Asp Ala Asn  Ile Gly Gly Val Ala  Ile Ala Pro 
    1040                 1045                 1050             


Ala His  Gly Ser Val Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His 
    1055                 1060                 1065             


Ala Thr  Thr Pro Val Glu His  Pro Asn Arg Asn His  Pro Thr Arg 
    1070                 1075                 1080             


Leu Ser  Leu Val Phe Tyr Gln  His Lys Asn Leu Asn  Lys Pro Gln 
    1085                 1090                 1095             


His Gly  Phe Glu Leu Asn Lys  Ile Lys Phe Glu Ala  Lys Glu Ala 
    1100                 1105                 1110             


Lys Asn  Lys Lys Met Lys Ala  Ser Glu Gln Lys Asp  Gln Ala Ala 
    1115                 1120                 1125             


Asn Glu  Gly Pro Glu Gln Ser  Ser Glu Val Asn Glu  Leu Asn Gln 
    1130                 1135                 1140             


Ile Pro  Ser His Lys Ala Leu  Thr Leu Thr His Asp  Asn Val Val 
    1145                 1150                 1155             


Thr Val  Ser Pro Tyr Ala Leu  Thr His Val Ala Gly  Pro Tyr Asn 
    1160                 1165                 1170             


His Trp  Val Ile Asp 
    1175             


<210>  56
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro 
1               5                   10                  15      


Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile 
            20                  25                  30          


Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg 
        35                  40                  45              


Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val 
    50                  55                  60                  


Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr 
65                  70                  75                  80  


Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly 
                85                  90                  95      


Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu 
            100                 105                 110         


Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His 
        115                 120                 125             


Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe 
    130                 135                 140                 


Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala 
                165                 170                 175     


Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg 
            180                 185                 190         


Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu 
        195                 200                 205             


Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr 
    210                 215                 220                 


Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe 
225                 230                 235                 240 


Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val 
                245                 250                 255     


Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu 
            260                 265                 270         


Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg 
        275                 280                 285             


His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
    290                 295                 300     


<210>  57
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  57

Gly Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp Lys Arg Gln Pro 
1               5                   10                  15      


Val Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys Val Leu Lys Ser 
            20                  25                  30          


Leu Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly Gly Thr Leu Lys 
        35                  40                  45              


Tyr Val Glu Asp Val Thr Asn Val Val Arg Arg Asp Val Glu Lys Trp 
    50                  55                  60                  


Gly Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro Leu Gly Ser Ser 
65                  70                  75                  80  


Cys Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe His Arg Ile Leu 
                85                  90                  95      


Gln Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro Phe Phe Trp Ile 
            100                 105                 110         


Phe Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln Glu Thr Thr Thr 
        115                 120                 125             


Arg Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp Val Arg Gly Arg 
    130                 135                 140                 


Asp Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile Pro Gly Leu Lys 
145                 150                 155                 160 


Ser Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu Tyr Leu Gln Ala 
                165                 170                 175     


Gln Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys Val Asp Leu Leu 
            180                 185                 190         


Val Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser 
        195                 200                 205             


Gln Asn Ser Leu Pro Leu 
    210                 


<210>  58
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro 
1               5                   10                  15      


Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile 
            20                  25                  30          


Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg 
        35                  40                  45              


Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val 
    50                  55                  60                  


Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr 
65                  70                  75                  80  


Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly 
                85                  90                  95      


Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu 
            100                 105                 110         


Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His 
        115                 120                 125             


Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe 
    130                 135                 140                 


Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala 
                165                 170                 175     


Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg 
            180                 185                 190         


Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu 
        195                 200                 205             


Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr 
    210                 215                 220                 


Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe 
225                 230                 235                 240 


Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val 
                245                 250                 255     


Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu 
            260                 265                 270         


Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg 
        275                 280                 285             


His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val Ser Ser Gly 
    290                 295                 300                 


Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser Gly Leu Val 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Gly Ser His Met Gly Pro Met Glu Ile Tyr Lys 
                325                 330                 335     


Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe 
            340                 345                 350         


Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly 
        355                 360                 365             


Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn 
    370                 375                 380                 


Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr 
385                 390                 395                 400 


Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp 
                405                 410                 415     


Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln 
            420                 425                 430         


Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu 
        435                 440                 445             


Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala 
    450                 455                 460                 


Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg 
465                 470                 475                 480 


Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr 
                485                 490                 495     


Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys 
            500                 505                 510         


Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro 
        515                 520                 525             


Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu 
    530                 535                 540             


<210>  59
<211>  1739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  59

Met Gly Pro Ala Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr 
1               5                   10                  15      


Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu 
            20                  25                  30          


Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile 
        35                  40                  45              


Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr 
    50                  55                  60                  


Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val 
65                  70                  75                  80  


Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu 
                85                  90                  95      


Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala 
            100                 105                 110         


Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr 
        115                 120                 125             


Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe 
    130                 135                 140                 


Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg 
145                 150                 155                 160 


Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys 
                165                 170                 175     


Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro 
            180                 185                 190         


Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu 
        195                 200                 205             


Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg 
    210                 215                 220                 


Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His 
225                 230                 235                 240 


Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu 
                245                 250                 255     


Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn 
            260                 265                 270         


Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val 
        275                 280                 285             


Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys 
    290                 295                 300                 


Val Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
                325                 330                 335     


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
            340                 345                 350         


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
        355                 360                 365             


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
    370                 375                 380                 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
385                 390                 395                 400 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
                405                 410                 415     


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
            420                 425                 430         


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
        435                 440                 445             


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
    450                 455                 460                 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
465                 470                 475                 480 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
                485                 490                 495     


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
            500                 505                 510         


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
        515                 520                 525             


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
    530                 535                 540                 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
545                 550                 555                 560 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
                565                 570                 575     


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
            580                 585                 590         


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
        595                 600                 605             


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
    610                 615                 620                 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
625                 630                 635                 640 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
                645                 650                 655     


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
            660                 665                 670         


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
        675                 680                 685             


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
    690                 695                 700                 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
705                 710                 715                 720 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
                725                 730                 735     


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
            740                 745                 750         


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
        755                 760                 765             


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
    770                 775                 780                 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
785                 790                 795                 800 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
                805                 810                 815     


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
            820                 825                 830         


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
        835                 840                 845             


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
    850                 855                 860                 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
865                 870                 875                 880 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
                885                 890                 895     


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
            900                 905                 910         


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
        915                 920                 925             


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
    930                 935                 940                 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
945                 950                 955                 960 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
                965                 970                 975     


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
            980                 985                 990         


Leu Lys Arg Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
        995                 1000                 1005             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1010                 1015                 1020             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1025                 1030                 1035             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1040                 1045                 1050             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1055                 1060                 1065             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1070                 1075                 1080             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1085                 1090                 1095             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1100                 1105                 1110             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1130                 1135                 1140             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1145                 1150                 1155             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1160                 1165                 1170             


Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile Val Pro  Gln Ser Phe 
    1175                 1180                 1185             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1190                 1195                 1200             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1205                 1210                 1215             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1220                 1225                 1230             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1235                 1240                 1245             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1250                 1255                 1260             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1265                 1270                 1275             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1280                 1285                 1290             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1295                 1300                 1305             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1310                 1315                 1320             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1325                 1330                 1335             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1340                 1345                 1350             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1355                 1360                 1365             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1370                 1375                 1380             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1385                 1390                 1395             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1400                 1405                 1410             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1415                 1420                 1425             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1430                 1435                 1440             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1445                 1450                 1455             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1460                 1465                 1470             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1475                 1480                 1485             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1490                 1495                 1500             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1505                 1510                 1515             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1520                 1525                 1530             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1535                 1540                 1545             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1550                 1555                 1560             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1565                 1570                 1575             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1580                 1585                 1590             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1595                 1600                 1605             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1610                 1615                 1620             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1625                 1630                 1635             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1640                 1645                 1650             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1655                 1660                 1665             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1670                 1675                 1680             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1685                 1690                 1695             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Pro Lys 
    1700                 1705                 1710             


Lys Lys  Arg Lys Val Glu Ala  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1715                 1720                 1725             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Pro Ala 
    1730                 1735                 


<210>  60
<211>  1652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Met Gly Pro Ala Gly Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp 
1               5                   10                  15      


Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys 
            20                  25                  30          


Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly 
        35                  40                  45              


Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn Val Val Arg Arg Asp 
    50                  55                  60                  


Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro 
65                  70                  75                  80  


Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe 
                85                  90                  95      


His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro 
            100                 105                 110         


Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln 
        115                 120                 125             


Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp 
    130                 135                 140                 


Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile 
145                 150                 155                 160 


Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu 
                165                 170                 175     


Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys 
            180                 185                 190         


Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe 
        195                 200                 205             


Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu Ile Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Tyr Pro Tyr Asp 
225                 230                 235                 240 


Val Pro Asp Tyr Ala Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
                245                 250                 255     


Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
            260                 265                 270         


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
        275                 280                 285             


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
    290                 295                 300                 


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
305                 310                 315                 320 


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
                325                 330                 335     


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
            340                 345                 350         


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
        355                 360                 365             


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
    370                 375                 380                 


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
385                 390                 395                 400 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
                405                 410                 415     


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
            420                 425                 430         


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
        435                 440                 445             


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
    450                 455                 460                 


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
465                 470                 475                 480 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
                485                 490                 495     


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
            500                 505                 510         


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
        515                 520                 525             


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
    530                 535                 540                 


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
545                 550                 555                 560 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
                565                 570                 575     


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
            580                 585                 590         


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
        595                 600                 605             


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
    610                 615                 620                 


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
625                 630                 635                 640 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
                645                 650                 655     


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
            660                 665                 670         


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
        675                 680                 685             


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
    690                 695                 700                 


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
705                 710                 715                 720 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
                725                 730                 735     


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
            740                 745                 750         


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
        755                 760                 765             


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
    770                 775                 780                 


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
785                 790                 795                 800 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
                805                 810                 815     


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
            820                 825                 830         


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
        835                 840                 845             


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
    850                 855                 860                 


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
865                 870                 875                 880 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
                885                 890                 895     


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
            900                 905                 910         


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
        915                 920                 925             


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
    930                 935                 940                 


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
945                 950                 955                 960 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
                965                 970                 975     


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
            980                 985                 990         


Leu Gln Thr Val Lys Val Val Asp  Glu Leu Val Lys Val  Met Gly Arg 
        995                 1000                 1005             


His Lys  Pro Glu Asn Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln 
    1010                 1015                 1020             


Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg 
    1025                 1030                 1035             


Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu 
    1040                 1045                 1050             


His Pro  Val Glu Asn Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu 
    1055                 1060                 1065             


Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu 
    1070                 1075                 1080             


Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val Asp Ala  Ile Val Pro 
    1085                 1090                 1095             


Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr 
    1100                 1105                 1110             


Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu 
    1115                 1120                 1125             


Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn 
    1130                 1135                 1140             


Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala 
    1145                 1150                 1155             


Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys 
    1160                 1165                 1170             


Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr Lys His  Val Ala Gln 
    1175                 1180                 1185             


Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys 
    1190                 1195                 1200             


Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val 
    1205                 1210                 1215             


Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile 
    1220                 1225                 1230             


Asn Asn  Tyr His His Ala His  Asp Ala Tyr Leu Asn  Ala Val Val 
    1235                 1240                 1245             


Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
    1250                 1255                 1260             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1265                 1270                 1275             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1280                 1285                 1290             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1295                 1300                 1305             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1310                 1315                 1320             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1325                 1330                 1335             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1340                 1345                 1350             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1355                 1360                 1365             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1370                 1375                 1380             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1385                 1390                 1395             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1400                 1405                 1410             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1415                 1420                 1425             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1430                 1435                 1440             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1445                 1450                 1455             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1460                 1465                 1470             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1475                 1480                 1485             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1490                 1495                 1500             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1505                 1510                 1515             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1520                 1525                 1530             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1535                 1540                 1545             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1550                 1555                 1560             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1565                 1570                 1575             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1580                 1585                 1590             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1595                 1600                 1605             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1610                 1615                 1620             


Ser Pro  Lys Lys Lys Arg Lys  Val Glu Ala Ser Gly  Gly Gly Gly 
    1625                 1630                 1635             


Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Pro Ala 
    1640                 1645                 1650         


<210>  61
<211>  1981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  61

Met Gly Pro Ala Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr 
1               5                   10                  15      


Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu 
            20                  25                  30          


Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile 
        35                  40                  45              


Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr 
    50                  55                  60                  


Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val 
65                  70                  75                  80  


Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu 
                85                  90                  95      


Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala 
            100                 105                 110         


Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr 
        115                 120                 125             


Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe 
    130                 135                 140                 


Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg 
145                 150                 155                 160 


Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys 
                165                 170                 175     


Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro 
            180                 185                 190         


Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu 
        195                 200                 205             


Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg 
    210                 215                 220                 


Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His 
225                 230                 235                 240 


Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu 
                245                 250                 255     


Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn 
            260                 265                 270         


Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val 
        275                 280                 285             


Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys 
    290                 295                 300                 


Val Ser Ser Gly Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser 
305                 310                 315                 320 


Ser Gly Leu Val Pro Leu Ser Leu Arg Gly Ser His Met Gly Pro Met 
                325                 330                 335     


Glu Ile Tyr Lys Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val 
            340                 345                 350         


Leu Ser Leu Phe Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe 
        355                 360                 365             


Leu Glu Ser Gly Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu 
    370                 375                 380                 


Asp Val Thr Asn Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe 
385                 390                 395                 400 


Asp Leu Val Tyr Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg 
                405                 410                 415     


Cys Pro Gly Trp Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala 
            420                 425                 430         


Leu Pro Arg Gln Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp 
        435                 440                 445             


Asn Leu Leu Leu Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu 
    450                 455                 460                 


Gln Thr Glu Ala Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln 
465                 470                 475                 480 


Asn Ala Met Arg Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His 
                485                 490                 495     


Ala Pro Leu Thr Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg 
            500                 505                 510         


Ser Arg Ser Lys Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn 
        515                 520                 525             


Cys Leu Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser 
    530                 535                 540                 


Leu Pro Leu Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro 
                565                 570                 575     


Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly 
            580                 585                 590         


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
        595                 600                 605             


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
    610                 615                 620                 


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
625                 630                 635                 640 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
                645                 650                 655     


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
            660                 665                 670         


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
        675                 680                 685             


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
    690                 695                 700                 


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
705                 710                 715                 720 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
                725                 730                 735     


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
            740                 745                 750         


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
        755                 760                 765             


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
    770                 775                 780                 


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
785                 790                 795                 800 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
                805                 810                 815     


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
            820                 825                 830         


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
        835                 840                 845             


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
    850                 855                 860                 


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
865                 870                 875                 880 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
                885                 890                 895     


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
            900                 905                 910         


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
        915                 920                 925             


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
    930                 935                 940                 


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
945                 950                 955                 960 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
                965                 970                 975     


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
            980                 985                 990         


Ser Ile Pro His Gln Ile His Leu  Gly Glu Leu His Ala  Ile Leu Arg 
        995                 1000                 1005             


Arg Gln  Glu Asp Phe Tyr Pro  Phe Leu Lys Asp Asn  Arg Glu Lys 
    1010                 1015                 1020             


Ile Glu  Lys Ile Leu Thr Phe  Arg Ile Pro Tyr Tyr  Val Gly Pro 
    1025                 1030                 1035             


Leu Ala  Arg Gly Asn Ser Arg  Phe Ala Trp Met Thr  Arg Lys Ser 
    1040                 1045                 1050             


Glu Glu  Thr Ile Thr Pro Trp  Asn Phe Glu Glu Val  Val Asp Lys 
    1055                 1060                 1065             


Gly Ala  Ser Ala Gln Ser Phe  Ile Glu Arg Met Thr  Asn Phe Asp 
    1070                 1075                 1080             


Lys Asn  Leu Pro Asn Glu Lys  Val Leu Pro Lys His  Ser Leu Leu 
    1085                 1090                 1095             


Tyr Glu  Tyr Phe Thr Val Tyr  Asn Glu Leu Thr Lys  Val Lys Tyr 
    1100                 1105                 1110             


Val Thr  Glu Gly Met Arg Lys  Pro Ala Phe Leu Ser  Gly Glu Gln 
    1115                 1120                 1125             


Lys Lys  Ala Ile Val Asp Leu  Leu Phe Lys Thr Asn  Arg Lys Val 
    1130                 1135                 1140             


Thr Val  Lys Gln Leu Lys Glu  Asp Tyr Phe Lys Lys  Ile Glu Cys 
    1145                 1150                 1155             


Phe Asp  Ser Val Glu Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala 
    1160                 1165                 1170             


Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys 
    1175                 1180                 1185             


Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile 
    1190                 1195                 1200             


Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu 
    1205                 1210                 1215             


Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp Asp Lys  Val Met Lys 
    1220                 1225                 1230             


Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg 
    1235                 1240                 1245             


Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile 
    1250                 1255                 1260             


Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met 
    1265                 1270                 1275             


Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln 
    1280                 1285                 1290             


Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser Leu His  Glu His Ile 
    1295                 1300                 1305             


Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln 
    1310                 1315                 1320             


Thr Val  Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
    1325                 1330                 1335             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    1340                 1345                 1350             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    1355                 1360                 1365             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    1370                 1375                 1380             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    1385                 1390                 1395             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    1400                 1405                 1410             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp Ala Ile  Val Pro Gln 
    1415                 1420                 1425             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    1430                 1435                 1440             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    1445                 1450                 1455             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    1460                 1465                 1470             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    1475                 1480                 1485             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    1490                 1495                 1500             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    1505                 1510                 1515             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    1520                 1525                 1530             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    1535                 1540                 1545             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    1550                 1555                 1560             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    1565                 1570                 1575             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    1580                 1585                 1590             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1595                 1600                 1605             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1610                 1615                 1620             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1625                 1630                 1635             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1640                 1645                 1650             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1655                 1660                 1665             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1670                 1675                 1680             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1685                 1690                 1695             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1700                 1705                 1710             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1715                 1720                 1725             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1730                 1735                 1740             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1745                 1750                 1755             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1760                 1765                 1770             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1775                 1780                 1785             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1790                 1795                 1800             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1805                 1810                 1815             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1820                 1825                 1830             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1835                 1840                 1845             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1850                 1855                 1860             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1865                 1870                 1875             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1880                 1885                 1890             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1895                 1900                 1905             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1910                 1915                 1920             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1925                 1930                 1935             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Glu Ala Ser Gly Gly  Gly Gly Ser 
    1955                 1960                 1965             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Pro  Ala 
    1970                 1975                 1980     


<210>  62
<211>  1738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  Asn His Asp Gln Glu  Phe Asp Pro 
    1430                 1435                 1440             


Pro Lys  Val Tyr Pro Pro Val  Pro Ala Glu Lys Arg  Lys Pro Ile 
    1445                 1450                 1455             


Arg Val  Leu Ser Leu Phe Asp  Gly Ile Ala Thr Gly  Leu Leu Val 
    1460                 1465                 1470             


Leu Lys  Asp Leu Gly Ile Gln  Val Asp Arg Tyr Ile  Ala Ser Glu 
    1475                 1480                 1485             


Val Cys  Glu Asp Ser Ile Thr  Val Gly Met Val Arg  His Gln Gly 
    1490                 1495                 1500             


Lys Ile  Met Tyr Val Gly Asp  Val Arg Ser Val Thr  Gln Lys His 
    1505                 1510                 1515             


Ile Gln  Glu Trp Gly Pro Phe  Asp Leu Val Ile Gly  Gly Ser Pro 
    1520                 1525                 1530             


Cys Asn  Asp Leu Ser Ile Val  Asn Pro Ala Arg Lys  Gly Leu Tyr 
    1535                 1540                 1545             


Glu Gly  Thr Gly Arg Leu Phe  Phe Glu Phe Tyr Arg  Leu Leu His 
    1550                 1555                 1560             


Asp Ala  Arg Pro Lys Glu Gly  Asp Asp Arg Pro Phe  Phe Trp Leu 
    1565                 1570                 1575             


Phe Glu  Asn Val Val Ala Met  Gly Val Ser Asp Lys  Arg Asp Ile 
    1580                 1585                 1590             


Ser Arg  Phe Leu Glu Ser Asn  Pro Val Met Ile Asp  Ala Lys Glu 
    1595                 1600                 1605             


Val Ser  Ala Ala His Arg Ala  Arg Tyr Phe Trp Gly  Asn Leu Pro 
    1610                 1615                 1620             


Gly Met  Asn Arg Pro Leu Ala  Ser Thr Val Asn Asp  Lys Leu Glu 
    1625                 1630                 1635             


Leu Gln  Glu Cys Leu Glu His  Gly Arg Ile Ala Lys  Phe Ser Lys 
    1640                 1645                 1650             


Val Arg  Thr Ile Thr Thr Arg  Ser Asn Ser Ile Lys  Gln Gly Lys 
    1655                 1660                 1665             


Asp Gln  His Phe Pro Val Phe  Met Asn Glu Lys Glu  Asp Ile Leu 
    1670                 1675                 1680             


Trp Cys  Thr Glu Met Glu Arg  Val Phe Gly Phe Pro  Val His Tyr 
    1685                 1690                 1695             


Thr Asp  Val Ser Asn Met Ser  Arg Leu Ala Arg Gln  Arg Leu Leu 
    1700                 1705                 1710             


Gly Arg  Ser Trp Ser Val Pro  Val Ile Arg His Leu  Phe Ala Pro 
    1715                 1720                 1725             


Leu Lys  Glu Tyr Phe Ala Cys  Val Ile Asp 
    1730                 1735             


<210>  63
<211>  1651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  Gly Pro Met Glu Ile  Tyr Lys Thr 
    1430                 1435                 1440             


Val Ser  Ala Trp Lys Arg Gln  Pro Val Arg Val Leu  Ser Leu Phe 
    1445                 1450                 1455             


Arg Asn  Ile Asp Lys Val Leu  Lys Ser Leu Gly Phe  Leu Glu Ser 
    1460                 1465                 1470             


Gly Ser  Gly Ser Gly Gly Gly  Thr Leu Lys Tyr Val  Glu Asp Val 
    1475                 1480                 1485             


Thr Asn  Val Val Arg Arg Asp  Val Glu Lys Trp Gly  Pro Phe Asp 
    1490                 1495                 1500             


Leu Val  Tyr Gly Ser Thr Gln  Pro Leu Gly Ser Ser  Cys Asp Arg 
    1505                 1510                 1515             


Cys Pro  Gly Trp Tyr Met Phe  Gln Phe His Arg Ile  Leu Gln Tyr 
    1520                 1525                 1530             


Ala Leu  Pro Arg Gln Glu Ser  Gln Arg Pro Phe Phe  Trp Ile Phe 
    1535                 1540                 1545             


Met Asp  Asn Leu Leu Leu Thr  Glu Asp Asp Gln Glu  Thr Thr Thr 
    1550                 1555                 1560             


Arg Phe  Leu Gln Thr Glu Ala  Val Thr Leu Gln Asp  Val Arg Gly 
    1565                 1570                 1575             


Arg Asp  Tyr Gln Asn Ala Met  Arg Val Trp Ser Asn  Ile Pro Gly 
    1580                 1585                 1590             


Leu Lys  Ser Lys His Ala Pro  Leu Thr Pro Lys Glu  Glu Glu Tyr 
    1595                 1600                 1605             


Leu Gln  Ala Gln Val Arg Ser  Arg Ser Lys Leu Asp  Ala Pro Lys 
    1610                 1615                 1620             


Val Asp  Leu Leu Val Lys Asn  Cys Leu Leu Pro Leu  Arg Glu Tyr 
    1625                 1630                 1635             


Phe Lys  Tyr Phe Ser Gln Asn  Ser Leu Pro Leu Ile  Asp 
    1640                 1645                 1650     


<210>  64
<211>  1980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Met Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
        35                  40                  45              


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    50                  55                  60                  


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
65                  70                  75                  80  


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                85                  90                  95      


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            100                 105                 110         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        115                 120                 125             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    130                 135                 140                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
145                 150                 155                 160 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                165                 170                 175     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            180                 185                 190         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        195                 200                 205             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    210                 215                 220                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
225                 230                 235                 240 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                245                 250                 255     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            260                 265                 270         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        275                 280                 285             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    290                 295                 300                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
305                 310                 315                 320 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                325                 330                 335     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            340                 345                 350         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        355                 360                 365             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
385                 390                 395                 400 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                405                 410                 415     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            420                 425                 430         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        435                 440                 445             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    450                 455                 460                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                485                 490                 495     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        515                 520                 525             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
545                 550                 555                 560 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                565                 570                 575     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            580                 585                 590         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        595                 600                 605             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    610                 615                 620                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
625                 630                 635                 640 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                645                 650                 655     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            660                 665                 670         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        675                 680                 685             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
705                 710                 715                 720 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                725                 730                 735     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            740                 745                 750         


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
        755                 760                 765             


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
    770                 775                 780                 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
785                 790                 795                 800 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
                805                 810                 815     


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
            820                 825                 830         


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
        835                 840                 845             


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
    850                 855                 860                 


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val 
865                 870                 875                 880 


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
                885                 890                 895     


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
            900                 905                 910         


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
        915                 920                 925             


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
    930                 935                 940                 


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
                965                 970                 975     


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
            980                 985                 990         


Val Ile Thr Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
        995                 1000                 1005             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1010                 1015                 1020             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1025                 1030                 1035             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1040                 1045                 1050             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1055                 1060                 1065             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1070                 1075                 1080             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1085                 1090                 1095             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1100                 1105                 1110             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1115                 1120                 1125             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1130                 1135                 1140             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1145                 1150                 1155             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1160                 1165                 1170             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1175                 1180                 1185             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1190                 1195                 1200             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1205                 1210                 1215             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1220                 1225                 1230             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1235                 1240                 1245             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1250                 1255                 1260             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1265                 1270                 1275             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1280                 1285                 1290             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1310                 1315                 1320             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1325                 1330                 1335             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1340                 1345                 1350             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1355                 1360                 1365             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1370                 1375                 1380             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Glu  Ala Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1415                 1420                 1425             


Gly Gly  Gly Ser Gly Pro Ala  Asn His Asp Gln Glu  Phe Asp Pro 
    1430                 1435                 1440             


Pro Lys  Val Tyr Pro Pro Val  Pro Ala Glu Lys Arg  Lys Pro Ile 
    1445                 1450                 1455             


Arg Val  Leu Ser Leu Phe Asp  Gly Ile Ala Thr Gly  Leu Leu Val 
    1460                 1465                 1470             


Leu Lys  Asp Leu Gly Ile Gln  Val Asp Arg Tyr Ile  Ala Ser Glu 
    1475                 1480                 1485             


Val Cys  Glu Asp Ser Ile Thr  Val Gly Met Val Arg  His Gln Gly 
    1490                 1495                 1500             


Lys Ile  Met Tyr Val Gly Asp  Val Arg Ser Val Thr  Gln Lys His 
    1505                 1510                 1515             


Ile Gln  Glu Trp Gly Pro Phe  Asp Leu Val Ile Gly  Gly Ser Pro 
    1520                 1525                 1530             


Cys Asn  Asp Leu Ser Ile Val  Asn Pro Ala Arg Lys  Gly Leu Tyr 
    1535                 1540                 1545             


Glu Gly  Thr Gly Arg Leu Phe  Phe Glu Phe Tyr Arg  Leu Leu His 
    1550                 1555                 1560             


Asp Ala  Arg Pro Lys Glu Gly  Asp Asp Arg Pro Phe  Phe Trp Leu 
    1565                 1570                 1575             


Phe Glu  Asn Val Val Ala Met  Gly Val Ser Asp Lys  Arg Asp Ile 
    1580                 1585                 1590             


Ser Arg  Phe Leu Glu Ser Asn  Pro Val Met Ile Asp  Ala Lys Glu 
    1595                 1600                 1605             


Val Ser  Ala Ala His Arg Ala  Arg Tyr Phe Trp Gly  Asn Leu Pro 
    1610                 1615                 1620             


Gly Met  Asn Arg Pro Leu Ala  Ser Thr Val Asn Asp  Lys Leu Glu 
    1625                 1630                 1635             


Leu Gln  Glu Cys Leu Glu His  Gly Arg Ile Ala Lys  Phe Ser Lys 
    1640                 1645                 1650             


Val Arg  Thr Ile Thr Thr Arg  Ser Asn Ser Ile Lys  Gln Gly Lys 
    1655                 1660                 1665             


Asp Gln  His Phe Pro Val Phe  Met Asn Glu Lys Glu  Asp Ile Leu 
    1670                 1675                 1680             


Trp Cys  Thr Glu Met Glu Arg  Val Phe Gly Phe Pro  Val His Tyr 
    1685                 1690                 1695             


Thr Asp  Val Ser Asn Met Ser  Arg Leu Ala Arg Gln  Arg Leu Leu 
    1700                 1705                 1710             


Gly Arg  Ser Trp Ser Val Pro  Val Ile Arg His Leu  Phe Ala Pro 
    1715                 1720                 1725             


Leu Lys  Glu Tyr Phe Ala Cys  Val Ser Ser Gly Asn  Ser Asn Ala 
    1730                 1735                 1740             


Asn Ser  Arg Gly Pro Ser Phe  Ser Ser Gly Leu Val  Pro Leu Ser 
    1745                 1750                 1755             


Leu Arg  Gly Ser His Met Gly  Pro Met Glu Ile Tyr  Lys Thr Val 
    1760                 1765                 1770             


Ser Ala  Trp Lys Arg Gln Pro  Val Arg Val Leu Ser  Leu Phe Arg 
    1775                 1780                 1785             


Asn Ile  Asp Lys Val Leu Lys  Ser Leu Gly Phe Leu  Glu Ser Gly 
    1790                 1795                 1800             


Ser Gly  Ser Gly Gly Gly Thr  Leu Lys Tyr Val Glu  Asp Val Thr 
    1805                 1810                 1815             


Asn Val  Val Arg Arg Asp Val  Glu Lys Trp Gly Pro  Phe Asp Leu 
    1820                 1825                 1830             


Val Tyr  Gly Ser Thr Gln Pro  Leu Gly Ser Ser Cys  Asp Arg Cys 
    1835                 1840                 1845             


Pro Gly  Trp Tyr Met Phe Gln  Phe His Arg Ile Leu  Gln Tyr Ala 
    1850                 1855                 1860             


Leu Pro  Arg Gln Glu Ser Gln  Arg Pro Phe Phe Trp  Ile Phe Met 
    1865                 1870                 1875             


Asp Asn  Leu Leu Leu Thr Glu  Asp Asp Gln Glu Thr  Thr Thr Arg 
    1880                 1885                 1890             


Phe Leu  Gln Thr Glu Ala Val  Thr Leu Gln Asp Val  Arg Gly Arg 
    1895                 1900                 1905             


Asp Tyr  Gln Asn Ala Met Arg  Val Trp Ser Asn Ile  Pro Gly Leu 
    1910                 1915                 1920             


Lys Ser  Lys His Ala Pro Leu  Thr Pro Lys Glu Glu  Glu Tyr Leu 
    1925                 1930                 1935             


Gln Ala  Gln Val Arg Ser Arg  Ser Lys Leu Asp Ala  Pro Lys Val 
    1940                 1945                 1950             


Asp Leu  Leu Val Lys Asn Cys  Leu Leu Pro Leu Arg  Glu Tyr Phe 
    1955                 1960                 1965             


Lys Tyr  Phe Ser Gln Asn Ser  Leu Pro Leu Ile Asp  
    1970                 1975                 1980 


<210>  65
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Met Gly Pro Ala Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr 
1               5                   10                  15      


Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu 
            20                  25                  30          


Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile 
        35                  40                  45              


Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr 
    50                  55                  60                  


Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val 
65                  70                  75                  80  


Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu 
                85                  90                  95      


Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala 
            100                 105                 110         


Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr 
        115                 120                 125             


Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe 
    130                 135                 140                 


Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg 
145                 150                 155                 160 


Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys 
                165                 170                 175     


Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro 
            180                 185                 190         


Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu 
        195                 200                 205             


Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg 
    210                 215                 220                 


Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His 
225                 230                 235                 240 


Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu 
                245                 250                 255     


Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn 
            260                 265                 270         


Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val 
        275                 280                 285             


Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys 
    290                 295                 300                 


Val Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
305                 310                 315                 320 


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
                325                 330                 335     


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
        355                 360                 365             


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
    370                 375                 380                 


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
385                 390                 395                 400 


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
                405                 410                 415     


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
            420                 425                 430         


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
        435                 440                 445             


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
    450                 455                 460                 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
465                 470                 475                 480 


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
                485                 490                 495     


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
            500                 505                 510         


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
        515                 520                 525             


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
    530                 535                 540                 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
545                 550                 555                 560 


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
                565                 570                 575     


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
            580                 585                 590         


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        595                 600                 605             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    610                 615                 620                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
625                 630                 635                 640 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                645                 650                 655     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            660                 665                 670         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        675                 680                 685             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    690                 695                 700                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
705                 710                 715                 720 


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
                725                 730                 735     


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Gly Pro Ala 
        755                 760     


<210>  66
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Met Gly Pro Ala Gly Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp 
1               5                   10                  15      


Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys 
            20                  25                  30          


Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly 
        35                  40                  45              


Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn Val Val Arg Arg Asp 
    50                  55                  60                  


Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro 
65                  70                  75                  80  


Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe 
                85                  90                  95      


His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro 
            100                 105                 110         


Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln 
        115                 120                 125             


Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp 
    130                 135                 140                 


Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile 
145                 150                 155                 160 


Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu 
                165                 170                 175     


Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys 
            180                 185                 190         


Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe 
        195                 200                 205             


Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu Ile Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys 
225                 230                 235                 240 


Val Asp Pro Lys Lys Lys Arg Lys Val Gly Ser Thr Gly Ser Arg Asn 
                245                 250                 255     


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Arg Ala Gly Ile Leu Pro Pro Lys Lys Lys Arg Lys Val Ser Arg 
        275                 280                 285             


Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
    290                 295                 300                 


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
305                 310                 315                 320 


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
                325                 330                 335     


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
            340                 345                 350         


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
        355                 360                 365             


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
    370                 375                 380                 


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
385                 390                 395                 400 


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
                405                 410                 415     


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
            420                 425                 430         


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
        435                 440                 445             


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
    450                 455                 460                 


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
465                 470                 475                 480 


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
                485                 490                 495     


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
            500                 505                 510         


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
        515                 520                 525             


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
    530                 535                 540                 


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
545                 550                 555                 560 


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
                565                 570                 575     


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
            580                 585                 590         


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
        595                 600                 605             


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
    610                 615                 620                 


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Asp Pro Lys 
625                 630                 635                 640 


Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Pro Ala 
        


<210>  67
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Asn His Asp Gln Glu Phe Asp 
    450                 455                 460                 


Pro Pro Lys Val Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile 
465                 470                 475                 480 


Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu 
                485                 490                 495     


Lys Asp Leu Gly Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys 
            500                 505                 510         


Glu Asp Ser Ile Thr Val Gly Met Val Arg His Gln Gly Lys Ile Met 
        515                 520                 525             


Tyr Val Gly Asp Val Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp 
    530                 535                 540                 


Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser 
545                 550                 555                 560 


Ile Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu 
                565                 570                 575     


Phe Phe Glu Phe Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly 
            580                 585                 590         


Asp Asp Arg Pro Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly 
        595                 600                 605             


Val Ser Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val 
    610                 615                 620                 


Met Ile Asp Ala Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe 
625                 630                 635                 640 


Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn 
                645                 650                 655     


Asp Lys Leu Glu Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys 
            660                 665                 670         


Phe Ser Lys Val Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln 
        675                 680                 685             


Gly Lys Asp Gln His Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile 
    690                 695                 700                 


Leu Trp Cys Thr Glu Met Glu Arg Val Phe Gly Phe Pro Val His Tyr 
705                 710                 715                 720 


Thr Asp Val Ser Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly 
                725                 730                 735     


Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys 
            740                 745                 750         


Glu Tyr Phe Ala Cys Val Ile Asp 
        755                 760 


<210>  68
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Gly Pro Met Glu Ile Tyr Lys 
    450                 455                 460                 


Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe 
465                 470                 475                 480 


Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn 
            500                 505                 510         


Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr 
        515                 520                 525             


Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp 
    530                 535                 540                 


Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln 
545                 550                 555                 560 


Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu 
                565                 570                 575     


Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala 
            580                 585                 590         


Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg 
        595                 600                 605             


Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr 
    610                 615                 620                 


Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys 
625                 630                 635                 640 


Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro 
                645                 650                 655     


Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu Ile 
            660                 665                 670         


Asp 
    


<210>  69
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  69

Met Ile Asp Gly Gly Gly Gly Ser Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ser Thr Gly Ser Arg Asn Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Arg Ala Gly Ile Leu Pro Pro Lys 
    50                  55                  60                  


Lys Lys Arg Lys Val Ser Arg Gly Arg Ser Arg Leu Leu Glu Asp Phe 
65                  70                  75                  80  


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
                85                  90                  95      


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu 
            100                 105                 110         


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
        115                 120                 125             


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
    130                 135                 140                 


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
145                 150                 155                 160 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
                165                 170                 175     


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
            180                 185                 190         


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
        195                 200                 205             


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
    210                 215                 220                 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
225                 230                 235                 240 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg 
                245                 250                 255     


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
            260                 265                 270         


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
        275                 280                 285             


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
    290                 295                 300                 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
305                 310                 315                 320 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
                325                 330                 335     


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
            340                 345                 350         


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
        355                 360                 365             


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
    370                 375                 380                 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
385                 390                 395                 400 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
                405                 410                 415     


Val Asp Leu Gly Asp Pro Lys Lys Lys Arg Lys Val Asp Pro Lys Lys 
            420                 425                 430         


Lys Arg Lys Val Gly Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Pro Ala Asn His Asp Gln Glu Phe Asp 
    450                 455                 460                 


Pro Pro Lys Val Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile 
465                 470                 475                 480 


Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu 
                485                 490                 495     


Lys Asp Leu Gly Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys 
            500                 505                 510         


Glu Asp Ser Ile Thr Val Gly Met Val Arg His Gln Gly Lys Ile Met 
        515                 520                 525             


Tyr Val Gly Asp Val Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp 
    530                 535                 540                 


Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser 
545                 550                 555                 560 


Ile Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu 
                565                 570                 575     


Phe Phe Glu Phe Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly 
            580                 585                 590         


Asp Asp Arg Pro Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly 
        595                 600                 605             


Val Ser Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val 
    610                 615                 620                 


Met Ile Asp Ala Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe 
625                 630                 635                 640 


Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn 
                645                 650                 655     


Asp Lys Leu Glu Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys 
            660                 665                 670         


Phe Ser Lys Val Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln 
        675                 680                 685             


Gly Lys Asp Gln His Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile 
    690                 695                 700                 


Leu Trp Cys Thr Glu Met Glu Arg Val Phe Gly Phe Pro Val His Tyr 
705                 710                 715                 720 


Thr Asp Val Ser Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly 
                725                 730                 735     


Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys 
            740                 745                 750         


Glu Tyr Phe Ala Cys Val Ser Ser Gly Asn Ser Asn Ala Asn Ser Arg 
        755                 760                 765             


Gly Pro Ser Phe Ser Ser Gly Leu Val Pro Leu Ser Leu Arg Gly Ser 
    770                 775                 780                 


His Met Gly Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp Lys Arg 
785                 790                 795                 800 


Gln Pro Val Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys Val Leu 
                805                 810                 815     


Lys Ser Leu Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly Gly Thr 
            820                 825                 830         


Leu Lys Tyr Val Glu Asp Val Thr Asn Val Val Arg Arg Asp Val Glu 
        835                 840                 845             


Lys Trp Gly Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro Leu Gly 
    850                 855                 860                 


Ser Ser Cys Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe His Arg 
865                 870                 875                 880 


Ile Leu Gln Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro Phe Phe 
                885                 890                 895     


Trp Ile Phe Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln Glu Thr 
            900                 905                 910         


Thr Thr Arg Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp Val Arg 
        915                 920                 925             


Gly Arg Asp Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile Pro Gly 
    930                 935                 940                 


Leu Lys Ser Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu Tyr Leu 
945                 950                 955                 960 


Gln Ala Gln Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys Val Asp 
                965                 970                 975     


Leu Leu Val Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe Lys Tyr 
            980                 985                 990         


Phe Ser Gln Asn Ser Leu Pro Leu  Ile Asp 
        995                 1000         


<210>  70
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  70
gcaggacggg ggcgcagaag agcagcggaa acagcaagca agaaaaaggc agccgacaac       60

gaaaaagggc accgagcggg ccaagggccc agagagagcc gagagccgag agccgagagc      120

cgagaagac                                                              129


<210>  71
<211>  127
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  71
gcgccggggc agaagaagag cagcggaaac agcaagcaag aaaaaggcag ccgacaacga       60

aaaagggcac cgagcgggcc aagggcccag agagagccga gagccgagag ccgagagccg      120

agaagac                                                                127


<210>  72
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  72
gccggccgcg cgggggaggc gaagagcagc ggaaacagca agcaagaaaa aggcagccga       60

caacgaaaaa gggcaccgag cgggccaagg gcccagagag agccgagagc cgagagccga      120

gagccgagaa gac                                                         133


<210>  73
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  73
ggcaggcgag gagggggagg gaagagcagc ggaaacagca agcaagaaaa aggcagccga       60

caacgaaaaa gggcaccgag cgggccaagg gcccagagag agccgagagc cgagagccga      120

gagccgagaa gac                                                         133


<210>  74
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  74
acagagttga gaaatttgac gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  75
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  75
gtcaaatttc tcaactctgt gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  76
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  76
gctcctaaaa acgaaccaat gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  77
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  77
aaacgaacca ataggaagag gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  78
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  78
cttcagcggc agctattgat gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  79
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  79
gcatctctgc tcctattggc gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  80
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  80
gcgccagatc acctcagcag gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  81
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  81
gcagagcgga ggaggtgctg tttaagagct atgctggaaa cagcatagca agtttaaata       60

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgccaatt gggtctccag      120

attgtatgta gcctgtatgt agcctgtatg tagcctgtat gtagcctgta tgtaagatct      180

tttttt                                                                 186


<210>  82
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  82
gaaggaagaa cgtgagcacg gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  83
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  83
ggcagtagcc gcttcaggga gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


<210>  84
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  84
gcgcaagcgc atatccttct gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgccaat tgggtctcca      120

gattgtatgt agcctgtatg tagcctgtat gtagcctgta tgtagcctgt atgtaagatc      180

ttttttt                                                                187


