                         SEQUENCE LISTING

<110>  TheVax Genetics Vaccine Co., Ltd.
 
<120>  HEPATITIS B THERAPEUTIC VACCINES

<130>  10021-00005

<150>  62396642
<151>  2016-09-19

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
            20                  25              


<210>  2
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln 
1               5                   10                  15      


Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val 
            20                  25                  30          


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly 
    50              


<210>  3
<211>  34
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  3

Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
1               5                   10                  15      


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
            20                  25                  30          


Ile Arg 
        


<210>  4
<211>  112
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  4

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            100                 105                 110         


<210>  5
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Glu Phe Glu Glu Pro Arg Val Ile Asp Leu Trp Asp Leu Ala Gln 
1               5                   10                  15      


Ser Ala Asn Leu Thr Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu Leu 
            20                  25                  30          


Lys His Phe Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln 
        35                  40                  45              


Leu Glu Ile Ala His Glu Lys Leu Arg His Ala Glu Ser Val Gly Asp 
    50                  55                  60                  


Gly Glu Arg Val Ser Arg Ser Arg Glu Lys His Ala Leu Leu Glu Gly 
65                  70                  75                  80  


Arg Thr Lys Glu Leu Gly Tyr Thr Val Lys Lys His Leu Gln Asp Leu 
                85                  90                  95      


Ser Gly Arg Ile Ser Arg Ala Arg 
            100                 


<210>  6
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Tyr Leu Gln Thr Ser Leu Lys Tyr Asn Ile Leu Pro Glu Lys Glu 
1               5                   10                  15      


Glu Phe Pro Phe Ala Leu Gly Val Gln Thr Leu Pro Gln Thr Cys Asp 
            20                  25                  30          


Glu Pro Lys Ala His Thr Ser Phe Gln Ile Ser Leu Ser Val Ser Tyr 
        35                  40                  45              


Thr Gly Ser Arg Ser Ala Ser Asn Met Ala Ile Val Asp Val Lys Met 
    50                  55                  60                  


Val Ser Gly Phe Ile Pro Leu Lys Pro Thr Val Lys Met Leu Glu Arg 
65                  70                  75                  80  


Ser Asn His Val Ser Arg Thr Glu Val Ser Ser Asn His Val Leu Ile 
                85                  90                  95      


Tyr Leu Asp Lys Val Ser Asn Gln Thr Leu Ser Leu Phe Phe Thr Val 
            100                 105                 110         


Leu Gln Asp Val Pro Val Arg Asp Leu Lys Pro Ala Ile Val Lys Val 
        115                 120                 125             


Tyr Asp Tyr Tyr Glu Thr Asp Glu Phe Ala Ile Ala Glu Tyr Asn Ala 
    130                 135                 140                 


Pro Cys Ser Lys Asp Leu Gly Asn Ala 
145                 150             


<210>  7
<211>  24
<212>  PRT
<213>  Human immunodeficiency virus

<400>  7

Arg Gly Asp Pro Thr Gly Gln Glu Glu Ser Lys Glu Lys Val Glu Lys 
1               5                   10                  15      


Glu Thr Val Val Asp Pro Val Thr 
            20                  


<210>  8
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  9
<211>  252
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  9

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
                245                 250         


<210>  10
<211>  613
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  10

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210>  11
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  11

Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg Glu Ser 
1               5                   10                  15      


Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu Lys Ala 
            20                  25                  30          


Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His Ala Asp 
        35                  40                  45              


Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu Lys Leu 
    50                  55                  60                  


Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile Arg Asn 
65                  70                  75                  80  


Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys Asp Ala 
                85                  90                  95      


Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp Gly Leu 
            100                 105                 110         


Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr Ser Gly 
        115                 120                 125             


Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe Leu His 
    130                 135                 140                 


His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr Leu Ser 
145                 150                 155                 160 


Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp Leu Ser 
                165                 170                 175     


Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu Lys Glu 
            180                 185                 190         


Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg Val Ser 
        195                 200                 205             


His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg Val Ile 
    210                 215                 220                 


Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys Glu Leu 
225                 230                 235                 240 


Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile Glu Lys 
                245                 250                 255     


His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys Leu Arg 
            260                 265                 270         


His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser Arg Glu 
        275                 280                 285             


Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr Thr Val 
    290                 295                 300                 


Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala Arg His 
305                 310                 315                 320 


Asn Glu Leu 
            


<210>  12
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  


Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      


Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         


Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             


Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 


Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 


Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     


Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         


Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             


Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 


Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 


Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     


Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         


Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             


Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 


Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 


Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     


Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         


Arg His Asn Glu Leu 
        355         


<210>  13
<211>  101
<212>  PRT
<213>  Human immunodeficiency virus

<400>  13

Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Lys Thr Pro Cys Thr Lys Cys Tyr Cys Lys Lys Cys Cys Leu 
            20                  25                  30          


His Cys Gln Val Cys Phe Met Thr Lys Gly Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Pro Gln Asp Asn Lys Asn 
    50                  55                  60                  


His Gln Val Ser Leu Ser Lys Gln Pro Thr Ser Arg Ala Arg Gly Asp 
65                  70                  75                  80  


Pro Thr Gly Gln Glu Glu Ser Lys Glu Lys Val Glu Lys Glu Thr Val 
                85                  90                  95      


Val Asp Pro Val Thr 
            100     


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention seqeunce

<400>  14

Lys Asp Glu Leu 
1               


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Arg Xaa Arg Xaa Lys Arg 
1               5       


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  16

Lys Lys Asp Leu Arg Asp Glu Leu Lys Asp Glu Leu 
1               5                   10          


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  17

Lys Lys Asp Glu Leu Arg Asp Glu Leu Lys Asp Glu Leu 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  18

Lys Lys Asp Glu Leu Arg Val Glu Leu Lys Asp Glu Leu 
1               5                   10              


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  19

Lys Asp Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu 
1               5                   10          


<210>  20
<211>  46
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  20

Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
1               5                   10                  15      


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
            20                  25                  30          


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
        35                  40                  45      


<210>  21
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCD28convPEt

<400>  21

Thr Asp Ile Tyr Phe Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Arg Ala Arg Tyr 
            20                  25                  30          


Lys Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
        35                  40                  45              


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
    50                  55                  60                  


Gln Val Ile Arg 
65              


<210>  22
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD28convPEt

<400>  22

Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Arg Ala Arg Tyr 
            20                  25                  30          


Lys Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
        35                  40                  45              


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
    50                  55                  60                  


Gln Val Ile Arg 
65              


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hepatitis B virus X protein deletion mutant

<400>  23

Met Ala Ala Arg Met Cys Cys Gln Leu Asp Pro Ala Arg Asp Val Leu 
1               5                   10                  15      


Cys Leu Arg Pro Ser His Leu Ser Leu Arg Gly Leu Pro Val Cys Ser 
            20                  25                  30          


Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg Arg 
        35                  40                  45              


Met Glu Thr Thr Val Asn Ala Pro Trp Ser Leu Pro Thr Val Leu His 
    50                  55                  60                  


Lys Arg Thr Ile Gly Leu Ser Gly Arg Ser Met Thr Trp Ile Glu Glu 
65                  70                  75                  80  


Tyr Ile Lys Asp Cys Val Phe Lys Asp Trp Glu Glu Leu Gly Glu Glu 
                85                  90                  95      


Ile Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val 
            100                 105                 110         


Cys Ser Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala 
        115                 120                 


<210>  24
<211>  154
<212>  PRT
<213>  Hepatitis B virus

<400>  24

Met Ala Ala Arg Met Cys Cys Gln Leu Asp Pro Ala Arg Asp Val Leu 
1               5                   10                  15      


Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro Leu Pro Gly 
            20                  25                  30          


Pro Leu Gly Ala Leu Pro Pro Ser Ser Ala Ser Ala Val Pro Ala Asp 
        35                  40                  45              


His Gly Ser His Leu Ser Leu Arg Gly Leu Pro Val Cys Ser Phe Ser 
    50                  55                  60                  


Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg Arg Met Glu 
65                  70                  75                  80  


Thr Thr Val Asn Ala Pro Trp Ser Leu Pro Thr Val Leu His Lys Arg 
                85                  90                  95      


Thr Ile Gly Leu Ser Gly Arg Ser Met Thr Trp Ile Glu Glu Tyr Ile 
            100                 105                 110         


Lys Asp Cys Val Phe Lys Asp Trp Glu Glu Leu Gly Glu Glu Ile Arg 
        115                 120                 125             


Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val Cys Ser 
    130                 135                 140                 


Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala 
145                 150                 


<210>  25
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAP1-mCD28convPEt-deletion mutant HBx-K3

<400>  25

Met Ala Glu Phe Glu Glu Pro Arg Val Ile Asp Leu Trp Asp Leu Ala 
1               5                   10                  15      


Gln Ser Ala Asn Leu Thr Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu 
            20                  25                  30          


Leu Lys His Phe Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys 
        35                  40                  45              


Gln Leu Glu Ile Ala His Glu Lys Leu Arg His Ala Glu Ser Val Gly 
    50                  55                  60                  


Asp Gly Glu Arg Val Ser Arg Ser Arg Glu Lys His Ala Leu Leu Glu 
65                  70                  75                  80  


Gly Arg Thr Lys Glu Leu Gly Tyr Thr Val Lys Lys His Leu Gln Asp 
                85                  90                  95      


Leu Ser Gly Arg Ile Ser Arg Ala Arg Glu Leu Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Arg Ala Arg Tyr Lys Arg Gly Trp Glu 
    130                 135                 140                 


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
145                 150                 155                 160 


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Gly 
                165                 170                 175     


Ser Glu Phe Met Ala Ala Arg Met Cys Cys Gln Leu Asp Pro Ala Arg 
            180                 185                 190         


Asp Val Leu Cys Leu Arg Pro Ser His Leu Ser Leu Arg Gly Leu Pro 
        195                 200                 205             


Val Cys Ser Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser 
    210                 215                 220                 


Ala Arg Arg Met Glu Thr Thr Val Asn Ala Pro Trp Ser Leu Pro Thr 
225                 230                 235                 240 


Val Leu His Lys Arg Thr Ile Gly Leu Ser Gly Arg Ser Met Thr Trp 
                245                 250                 255     


Ile Glu Glu Tyr Ile Lys Asp Cys Val Phe Lys Asp Trp Glu Glu Leu 
            260                 265                 270         


Gly Glu Glu Ile Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg His 
        275                 280                 285             


Lys Leu Val Cys Ser Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala Leu 
    290                 295                 300                 


Glu Lys Asp Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu 
305                 310                 315         


<210>  26
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAP1-hCD28convPEt-deletion mutant HBx-K3

<400>  26

Met Ala Glu Phe Glu Glu Pro Arg Val Ile Asp Leu Trp Asp Leu Ala 
1               5                   10                  15      


Gln Ser Ala Asn Leu Thr Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu 
            20                  25                  30          


Leu Lys His Phe Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys 
        35                  40                  45              


Gln Leu Glu Ile Ala His Glu Lys Leu Arg His Ala Glu Ser Val Gly 
    50                  55                  60                  


Asp Gly Glu Arg Val Ser Arg Ser Arg Glu Lys His Ala Leu Leu Glu 
65                  70                  75                  80  


Gly Arg Thr Lys Glu Leu Gly Tyr Thr Val Lys Lys His Leu Gln Asp 
                85                  90                  95      


Leu Ser Gly Arg Ile Ser Arg Ala Arg Glu Leu Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Arg Ala Arg Tyr Lys Arg Gly Trp Glu 
    130                 135                 140                 


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
145                 150                 155                 160 


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Gly 
                165                 170                 175     


Ser Glu Phe Met Ala Ala Arg Met Cys Cys Gln Leu Asp Pro Ala Arg 
            180                 185                 190         


Asp Val Leu Cys Leu Arg Pro Ser His Leu Ser Leu Arg Gly Leu Pro 
        195                 200                 205             


Val Cys Ser Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser 
    210                 215                 220                 


Ala Arg Arg Met Glu Thr Thr Val Asn Ala Pro Trp Ser Leu Pro Thr 
225                 230                 235                 240 


Val Leu His Lys Arg Thr Ile Gly Leu Ser Gly Arg Ser Met Thr Trp 
                245                 250                 255     


Ile Glu Glu Tyr Ile Lys Asp Cys Val Phe Lys Asp Trp Glu Glu Leu 
            260                 265                 270         


Gly Glu Glu Ile Arg Leu Lys Val Phe Val Leu Gly Gly Cys Arg His 
        275                 280                 285             


Lys Leu Val Cys Ser Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala Leu 
    290                 295                 300                 


Glu Lys Asp Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu 
305                 310                 315         


<210>  27
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28convPEt


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Thr Asp Ile Tyr Phe Cys Lys Xaa Glu Xaa Xaa Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Xaa Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Arg Xaa Arg Xaa 
            20                  25                  30          


Lys Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
        35                  40                  45              


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
    50                  55                  60                  


Gln Val Ile Arg 
65              


<210>  28
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 consensus sequence


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Thr Asp Ile Tyr Phe Cys Lys Xaa Glu Xaa Xaa Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Xaa Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
            20                  25              


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 critical region


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Lys Xaa Glu Xaa Xaa Tyr Pro Pro Pro Tyr 
1               5                   10  


<210>  30
<211>  61
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  30

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    50                  55                  60      


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV1-F'-EcoRI

<400>  31
gaattcatgg ctgctcgtat gtgctgc                                           27


<210>  32
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV20.51-S

<400>  32
ctgcgtccgt ctcacctgtc tctgcgtgg                                         29


<210>  33
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV20.51-A

<400>  33
gttctgtgcc tgcgtccgtc tcacctgtcg acaggtgaga cggacgcagg cacagaac         58


<210>  34
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBV154-R'-XhoI

<400>  34
ctcgagggca gaggtgaaga agttgcac                                          28


