                         SEQUENCE LISTING

<110>  WANG, MING-HAI
 
<120>  MONOCLONAL ANTIBODIES SPECIFIC TO THE PLEXIN-SEMAPHORIN-INTEGRIN 
       (PSI) DOMAIN OF RON FOR DRUG DELIVERY AND ITS APPLICATION IN 
       CANCER THERAPY

<130>  PCMT:2000WO

<140>  UNKNOWN
<141>  2017-09-01

<150>  62/384,989
<151>  2016-09-08

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  1
ggctacacct tcacagacta tcacatggat                                        30


<210>  2
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  2
gacatcaacc caaacaatgg cggcgccatc tacaatcaga agtttaaggg c                51


<210>  3
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
tctcactacg attatgctgg aggagcttgg ttcgcttac                              39


<210>  4
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
aagagctccc agagcctgct gttctccggc aaccagaaga attacctggc t                51


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
tgggcttcta ccagagctag c                                                 21


<210>  6
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
cagcagtact atagcttccc aagaacc                                           27


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Gly Tyr Thr Phe Thr Asp Tyr His Met Asp 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Asp Ile Asn Pro Asn Asn Gly Gly Ala Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Ser His Tyr Asp Tyr Ala Gly Gly Ala Trp Phe Ala Tyr 
1               5                   10              


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Lys Ser Ser Gln Ser Leu Leu Phe Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Trp Ala Ser Thr Arg Ala Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Gln Gln Tyr Tyr Ser Phe Pro Arg Thr 
1               5                   


<210>  13
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  13
gccgccacca tgggttggtc atgtattatt ctgtttctgg tggctactgc taccggcgtg       60

cattcccagg tgcagctggt ccagtctggg gctgaagtga agaagcccgg cgccaccgtg      120

aagatcagct gcaaggtgtc cggctacacc ttcacagact atcacatgga ttgggtgcag      180

caggctcctg gcaagggcct cgagtggatg ggcgacatca acccaaacaa tggcggcgcc      240

atctacaatc agaagtttaa gggccgggtg accatcacag ctgacacctc tacagatacc      300

gcctatatgg agctgagctc cctgagatcc gaggacacag ccgtgtacta ttgcgcccgg      360

tctcactacg attatgctgg aggagcttgg ttcgcttact ggggacaggg cacactggtg      420

accgtgagcc gggcttccac caagggccct agcgtgtttc cactggcccc ctcttccaag      480

tctacaagcg gaggaaccgc cgctctggga tgtctggtga aggattactt cccagagccc      540

gtgaccgtgt cttggaacag cggcgctctg acaagcggcg tgcacacatt tcctgccgtg      600

ctgcagtcct ctggcctgta ctccctgagc tccgtggtga cagtgccatc tagctccctg      660

ggcacacaga cctatatctg caacgtgaat cacaagccaa gcaataccaa ggtggacaag      720

aaggtggagc ccaagtcctg tgataagaca cacacctgcc ccccttgtcc tgctccagag      780

ctgctgggag gaccttccgt gttcctgttt ccacccaaac ctaaggacac actgatgatc      840

tctcggacac cagaggtgac ctgcgtggtg gtggacgtga gccacgagga tcccgaggtg      900

aagttcaact ggtatgtcga tggcgtggag gtgcacaatg ccaagaccaa gccccgggag      960

gagcagtaca actctacata tagggtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctcaacggca aggagtataa gtgcaaggtg tccaataagg ctctgcccgc ccctatcgag     1080

aagacaatct ctaaggctaa gggccagcct agggagccac aggtgtacac cctgcctcca     1140

tctagagacg agctgacaaa gaaccaggtg agcctgacct gtctggtgaa gggcttctat     1200

cccagcgata tcgccgtgga gtgggagtcc aatggccagc ctgagaacaa ttacaagacc     1260

acaccccctg tgctggactc cgatggctct ttctttctgt attccaagct gaccgtggat     1320

aagtctcggt ggcagcaggg caacgtgttc agctgttctg tgatgcacga agccctgcat     1380

aatcactata cccagaaatc cctgagtctg tcacctggaa agtga                     1425


<210>  14
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  14
gccgccacca tgggctggtc atgtattatt ctgtttctgg tcgcaactgc tactggggtg       60

catagcgaaa tcgtgatgac tcagtctccc ggaaccctgt ccctgtctcc aggcgagcgg      120

gccaccctgt cctgcaagag ctcccagagc ctgctgttct ccggcaacca gaagaattac      180

ctggcttggt atcagcagaa gccaggccag gctcccaggc tgctgatcta ctgggcttct      240

accagagcta gcggcatccc cgacaggttc agcggctccg gctctggcac agacttcacc      300

ctgacaatct ctagactgga gcctgaggac ttcgccgtgt actattgcca gcagtactat      360

agcttcccaa gaacctttgg ccagggcaca aagctggaga tcaagcggac cgtggccgct      420

cccagcgtgt tcatctttcc cccttccgac gagcagctga agtccggcac agcttctgtg      480

gtgtgcctgc tgaacaactt ctaccccagg gaggccaagg tccagtggaa ggtggataac      540

gctctgcaga gcggcaattc ccaggagtct gtgaccgagc aggacagcaa ggattccaca      600

tattctctgt ctagcaccct gacactgtct aaggccgatt acgagaagca caaggtgtat      660

gcttgtgaag tcacccacca gggtctgtca tcacccgtca ctaagtcttt taaccgaggc      720

gaatgctga                                                              729


<210>  15
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr His Met Asp Trp Val Gln Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Asn Pro Asn Asn Gly Gly Ala Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser His Tyr Asp Tyr Ala Gly Gly Ala Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  16
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Phe Ser Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Tyr Ser Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  17
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Pro Ile Arg Gly Pro Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys 
1               5                   10                  15      


Leu Arg Ala Trp His Phe Met Gly Cys Gly Trp Cys Gly Asn Met Cys 
            20                  25                  30          


Gly Gln Gln Lys Glu Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro 
        35                  40                  45              


Pro Lys Leu Thr Glu Phe 
    50                  


