                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  CELL DEATH BIOMARKER

<130>  AXH/75476PCT1

<150>  GB1615842.0
<151>  2016-09-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  9102
<212>  DNA
<213>  Homo sapiens

<400>  1
gagcgcatgc ccgcatctgc tgtccgacag gcggaagacg agcccagagg cggagcaggg       60

ccgtcgcgcc ttggtgacgt ctgccgccgg cgcgggcggg tgacgcgact gggcccgttg      120

tctgtgtgtg ggactgaggg gccccggggg cggtgggggc tcccggtggg ggcagcggtg      180

gggagggagg gcctggacat ggcgctgagg ggccgccccg cgggaagatg aataagggct      240

ggctggagct ggagagcgac ccaggtgagg aggggaccgg gagggccagg ggctggggag      300

gccggatggg cccgggacgc gcctgcctga ccatcacccc ctcctcttgt cgccccaccc      360

aggcctcttc accctgctcg tggaagattt cggtaagagc cttttctccc tgccggaccg      420

gggctgtggc ggcccacccc tgcgccctca ctcatcaggg gctgtccttc cctactgctt      480

tcctttcctc atcgcaggtg tcaagggggt gcaagtggag gagatctacg accttcagag      540

caaatgtcag gggtgagtgg ctgtacacca gggctgcccc ttacacccag agtgctgggg      600

aaggtcccag agaacagggc cccttaggga agacagtgcc aggaacccta cgttgtaaaa      660

tctcacagaa agcagcagcc ttgctctctg agtgcccgct cctgatcaaa ctgatacttt      720

cttttctccc aaactttcct tagcgcttcc ctttttgtag cagccccctc cccaccccta      780

agcatccttt ggttcagctg ctttcctggc cttgcagcgg gaagaccccg gtcacacaat      840

gtcttttgtg cagttgtgta atgtattaat tttagtgtgc ccatgtgtcc ttggctttaa      900

tcctgacaca aagtcatcct gtattgattg gttggggtga caaggcccct cctgggtgcc      960

cacacttaga gtcttttccc agtggtcctg cagaatagat gtgtaagaga gtagcaacag     1020

tagcaaccgt gactgaacca agaagtctac tttaatttcc tggaacaaaa gagactggtg     1080

tgggtgttca tttgctttcc tgactgcatt ggggcccaca agtgagaagg agtgcctcag     1140

ttcctcatca gagtttttgt tcttgtctta ctttgtgttc ctaccctgtc ccatccttgg     1200

ccctcagttc cagcttttct tctcttaccc agaactatag acttcataag gagactgggt     1260

ggactcctgg agcatcacag tcagaggctt atgctttgct ctgcctgtgg caggcctttg     1320

gtgtgtgagg gcacaaggcc acttcagaca cagtgttggg aagaagccag gggagagggg     1380

ggatcacagc aaggacacct gagtgatgac gcagtgcaaa ggattaatgg gagaaagaag     1440

ggaatgctga ttgtcttctc ccctttggct gatctggctc tgccccttac ttcccccagc     1500

cctgtatatg gatttatctt cctgttcaaa tggatcgaag agcgccggtc ccggcgaaag     1560

gtctctacct tggtggatga tacgtccgtg attgatgatg atattgtgaa taacatgttc     1620

tttgcccacc aggtctgctg gactctgtgc tttgtttgga gggtgggatg ctgccatgtt     1680

tttgcttggg aagtggaaat ggaggaagac aggaggagga gataggcaga ttctaggggt     1740

ggtagctaca gaaatcctct ggcagaacga actgaactct taattcatta aagggaacag     1800

ctttagagta ggagggtgtc tgagtccact ctctgtgtcc tcagatatcc agtgggtatt     1860

tggtaggtgc ttgttaaatg aataaacatt aggcaaagat gaaaggagct gagaagggga     1920

gttgtccaga tatgactgac ctgctctgga tccccattct tgatgtatat gggcttgggg     1980

cttgcagtga ggggtgctgt gtatgggtga ctattcttgg tttcacagct gatacccaac     2040

tcttgtgcaa ctcatgcctt gctgagcgtg ctcctgaact gcagcagcgt ggacctggga     2100

cccaccctga gtcgcatgaa ggacttcacc aagggtttca gccctgaggt aggctgcagt     2160

gccttcatcc tggctcacag ccaactgggc agatctgacc ctgagggcca ctgggaatgc     2220

taccacatga tattgggtac tattaggctg tttctttttc aaatgattgt ttatgttaca     2280

tttgactctt aaataaattg tgtaaggcca ttgtttttag atgcagttgc ggggaaagga     2340

cacaggccta gggagggagg agagtttcct taagtcagac catgtcagaa ccttctctgt     2400

caggactttt cctctcaggc catgttgctt cctagtgtcc actaattacc atgcaaggcc     2460

agcacagtcc atctctttgg ggctccagag ctcttttctg cccccaccag ccttttaaga     2520

aagttcgtct gtgttccttc cgattcctgg aatgcctcca ggctgctctc tgaagctttg     2580

ccttccaccc atagtcctac ctgaggagaa attattctga tacggcctta ttttcttccc     2640

cgtagagcaa aggatatgcg attggcaatg ccccggagtt ggccaaggcc cataatagcc     2700

atgccaggtg tgtgggagct gtgggagctg atgtggggtg ggagtagggg gagtatcatt     2760

ttttgggccc tgactctgtt tttccccagg cccgagccac gccacctccc tgagaagcag     2820

aatggcctta gtgcagtgcg gaccatggag gcgttccact ttgtcagcta tgtgcctatc     2880

acaggccggc tctttgagct ggatgggctg aaggtctacc ccattgacca tggtaggcac     2940

catgagctgg aggcctgttg ggtgtctctg cctacctcct agggagctgg ggctcagggc     3000

cctctggtat gtggtaccca gtggcagggg ttgtcggtac cgacacccgg ctctggctgg     3060

ggtttcaccc tacaccatat tgcccgacca gctcctgatt ccctggctca actgctcttc     3120

tctgtcttcc ttcccactcc tggcctgccc aaactcaggg tttccttctc gctgattcct     3180

tgtcttggtc tccactaggg ccctgggggg aggacgagga gtggacagac aaggcccggc     3240

gggtcatcat ggagcgtatc ggcctcgcca ctgcagggta agggccctgt gcctgccctg     3300

ttctactctc tggagctgta cctactttgg gagggacaga gagtatccag gtgatttgta     3360

aattgcaagg ccatatggtg aatctggcaa gatcaggctt agatcatggg ttctcaactt     3420

gttgtcttat ttcctgcctg ggctgcctgt ggcctgctcc tgggtgggct gggggagggg     3480

caggcctcag tggagcctta ggcagcccag gtctgctggt tcacttccag ataggcccct     3540

catacagctt gttggaaggt accagctcag gtgcctggca tgtatggcta gtcgctgcct     3600

gcctgttggg gtggggccta tacctacagc tgcaggtgtg actgcaggga gccctgccag     3660

gatatctgcc tcaacctgat ggcggggccg gggcgggagc tgctctcacg gctgcggctg     3720

tgactgcagg gagccctacc acgacatccg cttcaacctg atggcagtgg tgcccgaccg     3780

caggatcaag tatgaggcca ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga     3840

ggctctgcag caggtaggtg ccctttcttc ctggcctctg cccagcccaa ccctccctgc     3900

attcctcctc ccttccccca cagcatttgt ctctgattcg tgaacatact ctcttgtaga     3960

tctgggcttc agctaaccac atcttttctt tgcccccatt gtgggaaagg tgggacttgg     4020

agtggggagg gagaatagct tctaaaagga agtttgggtt tgggtgtttt atttccctgt     4080

gagtgaatgg gtagagccaa ggccattatt cctttaggtc ctcagccctt agctatttaa     4140

ggtagaagcc cgggtctacc ctttctcctc tgagccctgg attctgttgt tagctgataa     4200

gagtaacaca gccagagctg attcagaccc acaagtctca agagtcacag ctgcctgagg     4260

agtccaagtc agccagcaac aagtccccgc tggtgctgga agcaaacagg gcccctgcag     4320

cctctgaggg caaccacaca ggtactgggg ggtttgggac ctcttgtgga cctcagagcc     4380

acccgctaat gtctgacatg ggaggcctaa acagggaaag tctttttctg gggatgtcct     4440

tgggcagtgt tcttcccccg tcagaaggta gagggagagc agtccttccc taaagaaagg     4500

cacctgtaaa gggccgctgt taccacaggc ccctgggccc ttctctgtaa tgtacactcc     4560

ctttcttgtt ttctctagag gcggtttttt tttttttttt tttttttttt tttcttcctg     4620

cttctttttt cccatctcat tctttgccct gtctcattgc gggatcatga cttagagctt     4680

gctgactccc attgcaccag ctggctgggc tgttcttctc tgggaagtgc tggttcacag     4740

ggccggggag actgtgagct tttcttggag atcctactgg aggtcctgcc tgtgttcttg     4800

ccctgtctca gatggtgcag aggaggcggc tggttcatgc gcacaagccc catcccacag     4860

ccctcccaac aaacccaagc tagtggtgaa gcctccaggc agcagcctca atggggttca     4920

ccccaacccc actcccattg tccagcggct gccggccttt ctagacaatc acaattatgc     4980

caagtccccc atgcaggtaa gctgggagca cccttgcagg attctctact tgattctctt     5040

gagaggctgc aacaggcaat tttcccatgt ggttccttgg tgttcatcct tggcatggct     5100

gggtcaagct gcctgggcct gggttgctag gttcctctgc ctgatatgaa aaggccccca     5160

caacagcagg agcttaggga ggcagggaga gctcctttga atttaatcta gttacgtggc     5220

tgtgggatta aatgtttagg tcacgctcct tggtacaact tcatgggttg ggttttactg     5280

gcaaaataaa ggcatgtgtt tcagggcact ctgtttctct taaaacccct ccgtggggtt     5340

ctatccagtg taagtgggtg gcagcctccc cacaagccaa ggacaggcca tggaacagct     5400

ggaggggttc cgctgactca gtctggaaaa ccatgttggc tttctctctg gctgtgagtg     5460

tctaggctca gcctgggccg agcagcactt gtttgtaact gccctggtct ttgtcccagg     5520

aggaagaaga cctggcggca ggtgtgggcc gcagccgagt tccagtccgc ccaccccagc     5580

agtactcaga tgatgaggat gactatgagg atgacgagga ggatgacgtg cagaacacca     5640

actctgccct taggtcagcc cagctttcta aggctaccag gttctaggtg cttcggatcc     5700

catcctgaat atctcagtct gtgtctgaga atgccctgca gcagataatg ttgagcacct     5760

gcggagtttg gggccctggg ggaggctggc atgatggggc tgaccccagg tccccaggaa     5820

gtttttggtg ggctgggggg taaggctgag cacgtaagct tatatcatgt cctattggaa     5880

gtggcctttt agccaggcct tgaaggattg gttggggcag ggatggagga gatgtgggtg     5940

gtggggaggc agctttgctg gaacacaggg cattggcaaa aggccaggag tgggatggct     6000

ggaatagagg aagtgtcttt tgaggacact tggctgcagc tgtcagaact tgatgccagg     6060

cttagcatgg ctagttcaag ttgcttggac caagtataag gagttttagg gtcagcccct     6120

ggaggtcggg atgtatttaa gccattctgg gtactgctgg gtatggtcac ctggcccgtt     6180

cccttgcttc acatcttctc gggccccaca ggtataaggg gaagggaaca gggaagccag     6240

gggcattgag cggttctgct gatgggcaac tgtcagtgct gcagcccaac accatcaacg     6300

tcttggctga gaagctcaaa gagtcccaga aggacctctc aattcctctg tccatcaaga     6360

ctagcagcgg ggctgggagt ccggctgtgg cagtgcccac acactcgcag ccctcaccca     6420

cccccagcaa tgagagtaca gacacggcct ctgagatcgg cagtgctttc aactcgccac     6480

tgcgctcgcc tatccgctca gccaacccga cgcggccctc cagccctgtc acctcccaca     6540

tctccaaggt gctttttgga gaggatgaca gcctgctgcg tgttgactgc atacgctaca     6600

accgtgctgt ccgtgatctg ggtcctgtca tcagcacagg cctgctgcac ctggctgagg     6660

atggggtgct gagtcccctg gcgctgacag gtgggccttg gactggctca ctggccactt     6720

ggtgcaccca ggagggagga gggaagtggc caagtgacca caaagtgtcc tgcactctga     6780

tgattttctt gtgacctctc ttcccagagg gtgggaaggg ttcctcgccc tccatcagac     6840

caatccaagg cagccagggg tccagcagcc cagtggagaa ggaggtcgtg gaagccacgg     6900

acagcagaga gaagacgggg atggtgaggc ctggcgagcc cttgagtggg gagaaatact     6960

cacccaaggt gagcctccgt tgtggttttc tcctttaatc ctggcagagg gtaaggcctg     7020

agctcctcct gcccaggtgc caagttcttg attggaactt tggtgtgaag attggtggct     7080

ggagccatgt gccagaagac tttctgggtt gggtggtggc aggggccttg ataggcatgg     7140

actcgctgct catccttgcc tctagctgcc tattgctcgt ggggctttgt tgctggcccg     7200

ccccgatcag aggtgcaatg ctgggttttg gcaggagctg ctggcactgc tgaagtgtgt     7260

ggaggctgag attgcaaact atgaggcgtg cctcaaggag gaggtagaga agaggaagaa     7320

gttcaaggtg ggtgatttct ccagttgcct gatctggcct ctcccgaggt ccactggtgg     7380

ctgctctggc aagattggct ccagtgctct cagtcttctt ctctcctaca gattgatgac     7440

cagagaagga cccacaacta cgatgagttc atctgcacct ttatctccat gctggctcag     7500

gaaggtgagg ggatgcgctg ctgtcttaac tggaatgccc tgctgagggc cgtgtccttc     7560

agctcccctc ccctggcctc tcctgaggct tgagcagacc ttggggcaca gggagggcca     7620

tgagagcctc agctcctggc ctgaggcagc cagcacctgc tcaagggtct ctacctcttc     7680

gcaggcatgc tggccaacct agtggagcag aacatctccg tgcggcggcg ccaaggggtc     7740

agcatcggcc ggctccacaa gcagcggaag cctgaccggc ggaaacgctc tcgcccctac     7800

aaggccaagc gccagtgagg actgctggcc ctgactctgc agcccactct tgccgtgtgg     7860

ccctcaccag ggtccttccc tgccccactt ccccttttcc cagtattact gaatagtccc     7920

agctggagag tccaggccct gggaatggga ggaaccaggc cacattcctt ccatcgtgcc     7980

ctgaggcctg acacggcaga tcagccccat agtgctcagg aggcagcatc tggagttggg     8040

gcacagcgag gtactgcagc ttcctccaca gccggctgtg gagcagcagg acctggccct     8100

tctgcctggg cagcagaata tatattttac ctatcagaga catctatttt tctgggctcc     8160

aacccaacat gccaccatgt tgacataagt tcctacctga ctatgctttc tctcctagga     8220

gctgtcctgg tgggcccagg tccttgtatc atgccacggt cccaactaca gggtcctagc     8280

tgggggcctg ggtgggccct gggctctggg ccctgctgct ctagccccag ccaccagcct     8340

gtccctgttg taaggaagcc aggtcttctc tcttcattcc tcttaggaga gtgccaaact     8400

cagggaccca gcactgggct gggttgggag tagggtgtcc cagtggggtt ggggtgagca     8460

ggctgctggg atcccatggc ctgagcagag catgtgggaa ctgttcagtg gcctgtgaac     8520

tgtcttcctt gttctagcca ggctgttcaa gactgctctc catagcaagg ttctagggct     8580

cttcgccttc agtgttgtgg ccctagctat gggcctaaat tgggctctag gtctctgtcc     8640

ctggcgcttg aggctcagaa gagcctctgt ccagcccctc agtattacca tgtctccctc     8700

tcaggggtag cagagacagg gttgcttata ggaagctggc accactcagc tcttcctgct     8760

actccagttt cctcagcctc tgcaaggcac tcagggtggg ggacagcagg atcaagacaa     8820

cccgttggag cccctgtgtt ccagaggacc tgatgccaag gggtaatggg cccagcagtg     8880

cctctggagc ccaggcccca acacagcccc atggcctctg ccagatggct ttgaaaaagg     8940

tgatccaagc aggccccttt atctgtacat agtgactgag tggggggtgc tggcaagtgt     9000

ggcagctgcc tctgggctga gcacagcttg acccctctag cccctgtaaa tactggatca     9060

atgaatgaat aaaactctcc taagaatctc ctgagaaatg aa                        9102


<210>  2
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaataagg gctggctgga gctggagagc gacccaggcc tcttcaccct gctcgtggaa       60

gatttcggtg tcaagggggt gcaagtggag gagatctacg accttcagag caaatgtcag      120

ggccctgtat atggatttat cttcctgttc aaatggatcg aagagcgccg gtcccggcga      180

aaggtctcta ccttggtgga tgatacgtcc gtgattgatg atgatattgt gaataacatg      240

ttctttgccc accagctgat acccaactct tgtgcaactc atgccttgct gagcgtgctc      300

ctgaactgca gcagcgtgga cctgggaccc accctgagtc gcatgaagga cttcaccaag      360

ggtttcagcc ctgagagcaa aggatatgcg attggcaatg ccccggagtt ggccaaggcc      420

cataatagcc atgccaggcc cgagccacgc cacctccctg agaagcagaa tggccttagt      480

gcagtgcgga ccatggaggc gttccacttt gtcagctatg tgcctatcac aggccggctc      540

tttgagctgg atgggctgaa ggtctacccc attgaccatg ggccctgggg ggaggacgag      600

gagtggacag acaaggcccg gcgggtcatc atggagcgta tcggcctcgc cactgcaggg      660

gagccctacc acgacatccg cttcaacctg atggcagtgg tgcccgaccg caggatcaag      720

tatgaggcca ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga ggctctgcag      780

cagctgataa gagtaacaca gccagagctg attcagaccc acaagtctca agagtcacag      840

ctgcctgagg agtccaagtc agccagcaac aagtccccgc tggtgctgga agcaaacagg      900

gcccctgcag cctctgaggg caaccacaca gatggtgcag aggaggcggc tggttcatgc      960

gcacaagccc catcccacag ccctcccaac aaacccaagc tagtggtgaa gcctccaggc     1020

agcagcctca atggggttca ccccaacccc actcccattg tccagcggct gccggccttt     1080

ctagacaatc acaattatgc caagtccccc atgcaggagg aagaagacct ggcggcaggt     1140

gtgggccgca gccgagttcc agtccgccca ccccagcagt actcagatga tgaggatgac     1200

tatgaggatg acgaggagga tgacgtgcag aacaccaact ctgcccttag gtataagggg     1260

aagggaacag ggaagccagg ggcattgagc ggttctgctg atgggcaact gtcagtgctg     1320

cagcccaaca ccatcaacgt cttggctgag aagctcaaag agtcccagaa ggacctctca     1380

attcctctgt ccatcaagac tagcagcggg gctgggagtc cggctgtggc agtgcccaca     1440

cactcgcagc cctcacccac ccccagcaat gagagtacag acacggcctc tgagatcggc     1500

agtgctttca actcgccact gcgctcgcct atccgctcag ccaacccgac gcggccctcc     1560

agccctgtca cctcccacat ctccaaggtg ctttttggag aggatgacag cctgctgcgt     1620

gttgactgca tacgctacaa ccgtgctgtc cgtgatctgg gtcctgtcat cagcacaggc     1680

ctgctgcacc tggctgagga tggggtgctg agtcccctgg cgctgacaga gggtgggaag     1740

ggttcctcgc cctccatcag accaatccaa ggcagccagg ggtccagcag cccagtggag     1800

aaggaggtcg tggaagccac ggacagcaga gagaagacgg ggatggtgag gcctggcgag     1860

cccttgagtg gggagaaata ctcacccaag gagctgctgg cactgctgaa gtgtgtggag     1920

gctgagattg caaactatga ggcgtgcctc aaggaggagg tagagaagag gaagaagttc     1980

aagattgatg accagagaag gacccacaac tacgatgagt tcatctgcac ctttatctcc     2040

atgctggctc aggaaggcat gctggccaac ctagtggagc agaacatctc cgtgcggcgg     2100

cgccaagggg tcagcatcgg ccggctccac aagcagcgga agcctgaccg gcggaaacgc     2160

tctcgcccct acaaggccaa gcgccagtga                                      2190


<210>  3
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 
1               5                   10                  15      


Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 
            20                  25                  30          


Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 
        35                  40                  45              


Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr 
    50                  55                  60                  


Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 
65                  70                  75                  80  


Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 
                85                  90                  95      


Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 
            100                 105                 110         


Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 
        115                 120                 125             


Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 
    130                 135                 140                 


Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 
145                 150                 155                 160 


Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 
                165                 170                 175     


Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 
            180                 185                 190         


His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 
        195                 200                 205             


Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 
    210                 215                 220                 


Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 
225                 230                 235                 240 


Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 
                245                 250                 255     


Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 
            260                 265                 270         


Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 
        275                 280                 285             


Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 
    290                 295                 300                 


Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 
305                 310                 315                 320 


Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 
                325                 330                 335     


Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 
            340                 345                 350         


Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 
        355                 360                 365             


Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 
    370                 375                 380                 


Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 
385                 390                 395                 400 


Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 
                405                 410                 415     


Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 
            420                 425                 430         


Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 
        435                 440                 445             


Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 
    450                 455                 460                 


Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 
465                 470                 475                 480 


His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 
                485                 490                 495     


Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 
            500                 505                 510         


Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 
        515                 520                 525             


Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 
    530                 535                 540                 


Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 
545                 550                 555                 560 


Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 
                565                 570                 575     


Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 
            580                 585                 590         


Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 
        595                 600                 605             


Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 
    610                 615                 620                 


Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 
625                 630                 635                 640 


Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 
                645                 650                 655     


Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 
            660                 665                 670         


Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 
        675                 680                 685             


Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 
    690                 695                 700                 


Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 
705                 710                 715                 720 


Ser Arg Pro Tyr Lys Ala Lys Arg Gln 
                725                 


<210>  4
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 
1               5                   10                  15      


Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 
            20                  25                  30          


Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 
        35                  40                  45              


Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Gln Lys Val Ser Thr 
    50                  55                  60                  


Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 
65                  70                  75                  80  


Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 
                85                  90                  95      


Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 
            100                 105                 110         


Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 
        115                 120                 125             


Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 
    130                 135                 140                 


Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 
145                 150                 155                 160 


Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 
                165                 170                 175     


Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 
            180                 185                 190         


His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 
        195                 200                 205             


Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 
    210                 215                 220                 


Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 
225                 230                 235                 240 


Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 
                245                 250                 255     


Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 
            260                 265                 270         


Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 
        275                 280                 285             


Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 
    290                 295                 300                 


Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 
305                 310                 315                 320 


Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 
                325                 330                 335     


Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 
            340                 345                 350         


Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 
        355                 360                 365             


Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 
    370                 375                 380                 


Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 
385                 390                 395                 400 


Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 
                405                 410                 415     


Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 
            420                 425                 430         


Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 
        435                 440                 445             


Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 
    450                 455                 460                 


Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 
465                 470                 475                 480 


His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 
                485                 490                 495     


Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 
            500                 505                 510         


Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 
        515                 520                 525             


Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 
    530                 535                 540                 


Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 
545                 550                 555                 560 


Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 
                565                 570                 575     


Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 
            580                 585                 590         


Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 
        595                 600                 605             


Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 
    610                 615                 620                 


Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 
625                 630                 635                 640 


Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 
                645                 650                 655     


Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 
            660                 665                 670         


Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 
        675                 680                 685             


Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 
    690                 695                 700                 


Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 
705                 710                 715                 720 


Ser Arg Pro Tyr Lys Ala Lys Arg Gln 
                725                 


<210>  5
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaataagg gctggctgga gctggagagc gacccaggcc tcttcaccct gctcgtggaa       60

gatttcggtg tcaagggggt gcaagtggag gagatctacg accttcagag caaatgtcag      120

ggccctgtat atggatttat cttcctgttc aaatggatcg aagagcgccg gtcccggcaa      180

aaggtctcta ccttggtgga tgatacgtcc gtgattgatg atgatattgt gaataacatg      240

ttctttgccc accagctgat acccaactct tgtgcaactc atgccttgct gagcgtgctc      300

ctgaactgca gcagcgtgga cctgggaccc accctgagtc gcatgaagga cttcaccaag      360

ggtttcagcc ctgagagcaa aggatatgcg attggcaatg ccccggagtt ggccaaggcc      420

cataatagcc atgccaggcc cgagccacgc cacctccctg agaagcagaa tggccttagt      480

gcagtgcgga ccatggaggc gttccacttt gtcagctatg tgcctatcac aggccggctc      540

tttgagctgg atgggctgaa ggtctacccc attgaccatg ggccctgggg ggaggacgag      600

gagtggacag acaaggcccg gcgggtcatc atggagcgta tcggcctcgc cactgcaggg      660

gagccctacc acgacatccg cttcaacctg atggcagtgg tgcccgaccg caggatcaag      720

tatgaggcca ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga ggctctgcag      780

cagctgataa gagtaacaca gccagagctg attcagaccc acaagtctca agagtcacag      840

ctgcctgagg agtccaagtc agccagcaac aagtccccgc tggtgctgga agcaaacagg      900

gcccctgcag cctctgaggg caaccacaca gatggtgcag aggaggcggc tggttcatgc      960

gcacaagccc catcccacag ccctcccaac aaacccaagc tagtggtgaa gcctccaggc     1020

agcagcctca atggggttca ccccaacccc actcccattg tccagcggct gccggccttt     1080

ctagacaatc acaattatgc caagtccccc atgcaggagg aagaagacct ggcggcaggt     1140

gtgggccgca gccgagttcc agtccgccca ccccagcagt actcagatga tgaggatgac     1200

tatgaggatg acgaggagga tgacgtgcag aacaccaact ctgcccttag gtataagggg     1260

aagggaacag ggaagccagg ggcattgagc ggttctgctg atgggcaact gtcagtgctg     1320

cagcccaaca ccatcaacgt cttggctgag aagctcaaag agtcccagaa ggacctctca     1380

attcctctgt ccatcaagac tagcagcggg gctgggagtc cggctgtggc agtgcccaca     1440

cactcgcagc cctcacccac ccccagcaat gagagtacag acacggcctc tgagatcggc     1500

agtgctttca actcgccact gcgctcgcct atccgctcag ccaacccgac gcggccctcc     1560

agccctgtca cctcccacat ctccaaggtg ctttttggag aggatgacag cctgctgcgt     1620

gttgactgca tacgctacaa ccgtgctgtc cgtgatctgg gtcctgtcat cagcacaggc     1680

ctgctgcacc tggctgagga tggggtgctg agtcccctgg cgctgacaga gggtgggaag     1740

ggttcctcgc cctccatcag accaatccaa ggcagccagg ggtccagcag cccagtggag     1800

aaggaggtcg tggaagccac ggacagcaga gagaagacgg ggatggtgag gcctggcgag     1860

cccttgagtg gggagaaata ctcacccaag gagctgctgg cactgctgaa gtgtgtggag     1920

gctgagattg caaactatga ggcgtgcctc aaggaggagg tagagaagag gaagaagttc     1980

aagattgatg accagagaag gacccacaac tacgatgagt tcatctgcac ctttatctcc     2040

atgctggctc aggaaggcat gctggccaac ctagtggagc agaacatctc cgtgcggcgg     2100

cgccaagggg tcagcatcgg ccggctccac aagcagcgga agcctgaccg gcggaaacgc     2160

tctcgcccct acaaggccaa gcgccagtga                                      2190


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  6
acctagaacc tggtagcctt ag                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  7
gtacagctcc agagagtaga ac                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  8
tcttaccgaa atcttccacg ag                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  9
ctgctgcttt ctgtgagatt tt                                                22


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  10
agggcattcc agttaagaca g                                                 21


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  11
caagagtggg ctgcagag                                                     18


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  12
actaaggcca ttctgcttct c                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  13
atcccaccct ccaaacaaag                                                   20


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  14
caccaagtgg ccagtgag                                                     18


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  15
ggctgtcatc ctctccaaaa                                                   20


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  16
gagggctgcg agtgtgtg                                                     18


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  17
ctctgccagg attaaaggag aa                                                22


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  18
gaatgcaggg agggttgg                                                     18


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  19
acccaatatc atgtggtagc at                                                22


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  20
aaggacagcc cctgatga                                                     18


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  21
gtaggcagag acacccaac                                                    19


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  22
ccttctctgg tcatcaatct gt                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  23
ctctgaggtc cacaagaggt                                                   20


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  24
tcaagtagag aatcctgcaa gg                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  25
gagcagcact tgtttgtaac tg                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  26
ctcaactgct cttctctgtc tt                                                22


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  27
gagggagggc ctggacat                                                     18


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  28
ctgtccttcc ctactgcttt c                                                 21


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  29
gaagttcaag gtgggtgatt tc                                                22


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  30
ctcagctcct ggcctgag                                                     18


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  31
ggagaaatta ttctgatacg gcc                                               23


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  32
gaagggaatg ctgattgtct tc                                                22


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  33
ctatccgctc agccaacc                                                     18


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  34
ctctcaattc ctctgtccat ca                                                22


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  35
cgttcccttg cttcacatct                                                   20


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  36
tcctgcactc tgatgatttt ct                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  37
gatatctgcc tcaacctgat gg                                                22


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  38
gtgctgtgta tgggtgacta                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  39
gaagatgaat aagggctggc t                                                 21


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  40
tgatgtgggg tgggagtag                                                    19


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  41
cccgatcaga ggtgcaat                                                     18


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  42
agctatttaa ggtagaagcc cg                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  43
actgtgagct tttcttggag at                                                22


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence for short hairpin

<400>  44
taaaggtgca gatgaactc                                                    19


