                         SEQUENCE LISTING

<110>  Adamed sp. z o.o.
       Pawlak, Sebastian  Dominik
 
<120>  Przeciwnowotworowe biako fuzyjne

<130>  Biol/KM/ONCOSTATM

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  1

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg Gly Gly Gly Gly Ser Ala Ser Gly Gly Pro Glu Gly 
        195                 200                 205             


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
    210                 215                 220                 


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
225                 230                 235                 240 


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
                245                 250                 255     


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Ala Asn Ala Leu Ala 
            260                 265                 270         


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Ser Pro 
        275                 280                 285             


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
    290                 295                 300                 


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
305                 310                 315                 320 


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
                325                 330                 335     


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
            340                 345                 350         


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
        355                 360                 365             


Glu Glu Ala Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
    370                 375                 380                 


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
385                 390                 395                 400 


Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
                405                 410                 415     


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile 
            420                 425                 430         


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
        435                 440                 445             


Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
    450                 455                 460                 


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
465                 470                 475                 480 


Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly 
                485                 490                 495     


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
            500                 505                 510         


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
        515                 520                 525             


Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
    530                 535                 540                 


Lys Pro Pro Lys Asp Glu Leu 
545                 550     


<210>  2
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biako fuzyjne

<400>  2

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Ala Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg Gly Gly Gly Gly Ser Ala Ser Gly Gly Pro Glu Gly 
        195                 200                 205             


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
    210                 215                 220                 


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
225                 230                 235                 240 


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
                245                 250                 255     


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Ala Asn Ala Leu Ala 
            260                 265                 270         


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Ser Pro 
        275                 280                 285             


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
    290                 295                 300                 


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
305                 310                 315                 320 


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
                325                 330                 335     


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
            340                 345                 350         


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
        355                 360                 365             


Glu Glu Ala Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
    370                 375                 380                 


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
385                 390                 395                 400 


Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
                405                 410                 415     


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile 
            420                 425                 430         


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
        435                 440                 445             


Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
    450                 455                 460                 


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
465                 470                 475                 480 


Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly 
                485                 490                 495     


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
            500                 505                 510         


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
        515                 520                 525             


Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
    530                 535                 540                 


Lys Pro Pro Lys Asp Glu Leu 
545                 550     


<210>  3
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biako fuzyjne

<400>  3

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Ala Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg Gly Gly Gly Gly Ser Ala Ser Gly Gly Pro Glu Gly 
        195                 200                 205             


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
    210                 215                 220                 


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
225                 230                 235                 240 


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
                245                 250                 255     


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Ala Asn Ala Leu Ala 
            260                 265                 270         


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Ser Pro 
        275                 280                 285             


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
    290                 295                 300                 


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
305                 310                 315                 320 


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
                325                 330                 335     


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
            340                 345                 350         


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
        355                 360                 365             


Glu Glu Ala Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
    370                 375                 380                 


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
385                 390                 395                 400 


Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
                405                 410                 415     


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile 
            420                 425                 430         


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
        435                 440                 445             


Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
    450                 455                 460                 


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
465                 470                 475                 480 


Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly 
                485                 490                 495     


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
            500                 505                 510         


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
        515                 520                 525             


Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
    530                 535                 540                 


Lys Pro Pro Lys Asp Glu Leu 
545                 550     


<210>  4
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biako fuzyjne

<400>  4

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Ala Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Ala Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg Gly Gly Gly Gly Ser Ala Ser Gly Gly Pro Glu Gly 
        195                 200                 205             


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
    210                 215                 220                 


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
225                 230                 235                 240 


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
                245                 250                 255     


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Ala Asn Ala Leu Ala 
            260                 265                 270         


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Ser Pro 
        275                 280                 285             


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
    290                 295                 300                 


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
305                 310                 315                 320 


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
                325                 330                 335     


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
            340                 345                 350         


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
        355                 360                 365             


Glu Glu Ala Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
    370                 375                 380                 


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
385                 390                 395                 400 


Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
                405                 410                 415     


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile 
            420                 425                 430         


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
        435                 440                 445             


Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
    450                 455                 460                 


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
465                 470                 475                 480 


Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly 
                485                 490                 495     


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
            500                 505                 510         


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
        515                 520                 525             


Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
    530                 535                 540                 


Lys Pro Pro Lys Asp Glu Leu 
545                 550     


<210>  5
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biako fuzyjne

<400>  5

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Gly Gly Gly Asn 
                85                  90                  95      


Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu Gly 
            100                 105                 110         


Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser Asp 
        115                 120                 125             


Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro Thr 
    130                 135                 140                 


Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys Arg 
145                 150                 155                 160 


Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val Phe 
                165                 170                 175     


Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg Gly Gly Gly Gly 
            180                 185                 190         


Ser Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala 
        195                 200                 205             


His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
225                 230                 235                 240 


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
                245                 250                 255     


Gln Val Ile Ala Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu 
            260                 265                 270         


Gly Glu Ala Ile Arg Glu Ser Pro Glu Gln Ala Arg Leu Ala Leu Thr 
        275                 280                 285             


Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn 
    290                 295                 300                 


Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu 
305                 310                 315                 320 


Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly 
                325                 330                 335     


Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg 
            340                 345                 350         


Leu Leu Gln Ala His Arg Gln Leu Glu Glu Ala Gly Tyr Val Phe Val 
        355                 360                 365             


Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly 
    370                 375                 380                 


Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Ala Gly Phe 
385                 390                 395                 400 


Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln 
                405                 410                 415     


Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val 
            420                 425                 430         


Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Ala Thr Ser Leu Thr 
        435                 440                 445             


Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His 
    450                 455                 460                 


Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Ser Gly 
465                 470                 475                 480 


Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val 
                485                 490                 495     


Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp 
            500                 505                 510         


Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu Gln Ala Ile Ser Ala Leu 
        515                 520                 525             


Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
    530                 535                 540             


<210>  6
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg 
        195     


<210>  7
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Ala Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg 
        195     


<210>  8
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Ala Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg 
        195     


<210>  9
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Ala Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Pro Lys Ala Gln 
                85                  90                  95      


Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu Glu Lys Leu Gln 
            100                 105                 110         


Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys Met 
        115                 120                 125             


Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala Gly 
    130                 135                 140                 


Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala Phe 
145                 150                 155                 160 


Gln Arg Ala Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg Phe 
                165                 170                 175     


Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro Asn 
            180                 185                 190         


Arg Ser Arg Arg 
        195     


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val Leu Leu Gly Gln 
1               5                   10                  15      


Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser Arg Leu Leu Asp 
            20                  25                  30          


Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys Leu Arg Glu His 
        35                  40                  45              


Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu Thr Leu Arg Gly 
    50                  55                  60                  


Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala Thr Leu Gly Cys 
65                  70                  75                  80  


Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu Gly Gly Gly Asn 
                85                  90                  95      


Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu Gly 
            100                 105                 110         


Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser Asp 
        115                 120                 125             


Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro Thr 
    130                 135                 140                 


Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys Arg 
145                 150                 155                 160 


Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val Phe 
                165                 170                 175     


Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg 
            180                 185             


<210>  11
<211>  342
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  11

Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His 
1               5                   10                  15      


Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
            20                  25                  30          


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
        35                  40                  45              


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Ala Asn 
    50                  55                  60                  


Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg 
65                  70                  75                  80  


Glu Ser Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu 
                85                  90                  95      


Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala 
            100                 105                 110         


Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr 
        115                 120                 125             


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
    130                 135                 140                 


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
145                 150                 155                 160 


Arg Gln Leu Glu Glu Ala Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
                165                 170                 175     


Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg 
            180                 185                 190         


Ser Gln Asp Leu Asp Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp 
        195                 200                 205             


Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala 
    210                 215                 220                 


Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser 
225                 230                 235                 240 


Ser Leu Pro Gly Phe Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg 
            260                 265                 270         


Leu Asp Ala Ile Thr Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr 
        275                 280                 285             


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
    290                 295                 300                 


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
305                 310                 315                 320 


Ile Pro Asp Ser Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
                325                 330                 335     


Gln Pro Gly Lys Pro Pro 
            340         


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker steryczny

<400>  12

Gly Gly Gly Gly Ser Ala Ser Gly Gly 
1               5                   


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motyw kierujcy do retikulum

<400>  13

Lys Asp Glu Leu 
1               


