
                                SEQUENCE LISTING

<110> Icellhealth Consulting LLC
      SONG, XIAOTONG

<120> ONCOLYTIC VIRUS EXPRESSING IMMUNE
      CHECKPOINT MODULATORS

<130> 768312000240

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> 62/385,933    
<151> 2016-09-09

<150> 62/385,930    
<151> 2016-09-09

<160> 45

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-H1

<400> 1
Asp Tyr Tyr Ile Asn
 1               5  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-H2

<400> 2
Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-H3

<400> 3
Ala Phe Tyr Arg Tyr Asp Val Gly Ala Tyr
 1               5                  10  


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-L1

<400> 4
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala
 1               5                  10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-L2

<400> 5
Ser Ala Ser Tyr Arg Tyr Ser
 1               5          


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 HVR-L3

<400> 6
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr
 1               5                  


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-H1

<400> 7
Asp Tyr Tyr Ile Asn
 1               5  


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-H2

<400> 8
Trp Ile Tyr Pro Gly Thr Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-H3

<400> 9
Ser Tyr Tyr Arg Tyr Asp Val Gly Ala Tyr
 1               5                  10  


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-L1

<400> 10
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala
 1               5                  10      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-L2

<400> 11
Ser Ala Ser Tyr Arg Tyr Ser
 1               5          


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 HVR-L3

<400> 12
Gln Gln Tyr Asn Ile Tyr Pro Trp Thr
 1               5                  


<210> 13
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 VH

<400> 13
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Glu Gly Ala Phe Tyr Arg Tyr Asp Val Gly Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 14
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3 VL

<400> 14
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 15
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 VH

<400> 15
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Thr Gly Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Glu Gly Ser Tyr Tyr Arg Tyr Asp Val Gly Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 16
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4F11C3 VL

<400> 16
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 17
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-PD-1 1H7e3 VH

<400> 17
cagatccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctgcaagg cttctggcta caccttcact gactactata taaactgggt gaagcagaag 120
cctggacagg gacttgagtg gattggatgg atttatcctg gaagcggtaa tactaagtac 180
aatgagaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac 240
atgcagctca gcagcctgac atctgaggac actgctgtct atttctgtga gggggccttc 300
tataggtacg acgttggagc ttactggggc caagggactc tggtcactgt ctctgca    357

<210> 18
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-PD-1 1H7e3 VL

<400> 18
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60
gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca 120
gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct 240
gaagacttgg cagagtattt ctgtcagcaa tataacagct atccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa a                                           321

<210> 19
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-PD-1 4F11C3 VH

<400> 19
cagatccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctgcaagg cttctggcta caccttcact gactactata taaactgggt gaagcagaag 120
cctggacagg gacttgagtg gattggatgg atttatcctg gaaccggtaa tactaagtac 180
aatgagaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac 240
atgcagctca gcagcctgac atctgaggac actgctgtct atttctgtga ggggtcctac 300
tataggtacg acgttggagc ttactggggc caagggactc tggtcactgt ctctgca    357

<210> 20
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-PD-1 4F11C3 VL

<400> 20
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60
gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca 120
gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct 240
gaagacttgg cagagtattt ctgtcagcaa tataacatct atccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa a                                           321

<210> 21
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3, 4F11C3 VH signal peptide

<400> 21
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val His Cys
            


<210> 22
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid encoding 1H7e3, 4F11C3 VH signal peptide

<400> 22
atgggatgga gctggatctt tcttttcctc ctgtcaggaa ctgcaggtgt ccattgc    57

<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H7e3, 4F11C3 VL signal peptide

<400> 23
Met Gly Ile Lys Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu
 1               5                  10                  15      
Leu Trp Leu Ser Gly Val Asp Gly
            20                  


<210> 24
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid encoding 1H7e3, 4F11C3 VL signal peptide

<400> 24
atgggcatca agatggagtc acagactcag gtctttgtat acatgttgct gtggttgtct 60
ggtgttgatg ga                                                     72

<210> 25
<211> 167
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 extracellular domain

<400> 25
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
 1               5                  10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln
                165         


<210> 26
<211> 501
<212> DNA
<213> Artificial Sequence

<220> 
<223> PD-1 extracellular domain

<400> 26
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg 60
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt cttcccagcc 120
ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg 180
gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc 240
gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg 300
cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc 360
tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca 420
gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc 480
aggccagccg gccagttcca a                                           501

<210> 27
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> TMIGD2 extracellular domain

<400> 27
Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser
 1               5                  10                  15      
Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg
            20                  25                  30          
Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr
        35                  40                  45              
Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg
    50                  55                  60                  
Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val
65                  70                  75                  80  
Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile
                85                  90                  95      
Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr Arg Leu Phe Val Asp
            100                 105                 110         
Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg Ile Ala Ser Phe Pro Gly
        115                 120                 125             


<210> 28
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> signal peptide of TMIGD2 extracellular domain-Fc 
fusion protein

<400> 28
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala
 1               5                  10                  15      
Leu Gln Glu Ala Ser Ser
            20          


<210> 29
<211> 343
<212> PRT
<213> Artificial Sequence

<220> 
<223> SIRPalpha extracellular domain

<400> 29
Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala
 1               5                  10                  15      
Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro
            20                  25                  30          
Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu
        35                  40                  45              
Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser
    50                  55                  60                  
Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn
65                  70                  75                  80  
Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys
                85                  90                  95      
Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu
            100                 105                 110         
Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala
        115                 120                 125             
Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly
    130                 135                 140                 
Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu
145                 150                 155                 160 
Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser
                165                 170                 175     
Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val
            180                 185                 190         
His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp
        195                 200                 205             
Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro
    210                 215                 220                 
Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn
225                 230                 235                 240 
Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr
                245                 250                 255     
Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val
            260                 265                 270         
Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val
        275                 280                 285             
Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu
    290                 295                 300                 
His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser
305                 310                 315                 320 
Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly
                325                 330                 335     
Ser Asn Glu Arg Asn Ile Tyr
            340             


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CXCL12 N terminal sequence

<400> 30
Lys Arg Tyr Ser Leu Ser Val Gly Lys
 1               5                  


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker (IgG1 hinge) between SIRPalpha extracellular 
domain and CXCL12

<400> 31
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 32
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> signal peptide of SIRPalpha-CXCL12-Fc fusion protein

<400> 32
Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys
 1               5                  10                  15      
Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly
            20                  25                  30  


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-VL linker amino acid sequence

<400> 33
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-VL linker amino acid sequence

<400> 34
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala
 1               5                  10                  


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv-scFv linker amino acid sequence

<400> 35
Gly Gly Gly Gly Ser
 1               5  



<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H1

<400> 36
Glu Asn Ile Ile His
 1               5  


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H2

<400> 37
Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 38
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H3

<400> 38
His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr
 1               5                  10      


<210> 39
<211> 15
<212> PRT
<213> FAP HVR-L1

<220> 
<223> Synthetic Construct

<400> 39
Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His
 1               5                  10                  15  


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-L2

<400> 40
Leu Ala Ser Asn Leu Glu Ser
 1               5          


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-L3

<400> 41
Gln His Ser Arg Glu Leu Pro Tyr Thr
 1               5                  


<210> 42
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP VH

<400> 42
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 43
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP VL

<400> 43
Gln Ile Leu Met Thr Gln Ser Pro Ala Ser Ser Val Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
            20                  25                  30          
Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Pro
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         
Ala
    


<210> 44
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP scFv

<400> 44
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser Pro Ala Ser
    130                 135                 140                 
Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
145                 150                 155                 160 
Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln
                165                 170                 175     
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu
            180                 185                 190         
Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205             
Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
    210                 215                 220                 
Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg Ala
                245         


<210> 45
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP-human CD3 TE 

<400> 45
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser Pro Ala Ser
    130                 135                 140                 
Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
145                 150                 155                 160 
Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln
                165                 170                 175     
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu
            180                 185                 190         
Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205             
Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
    210                 215                 220                 
Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu
                245                 250                 255     
Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met
            260                 265                 270         
Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp
        275                 280                 285             
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn
    290                 295                 300                 
Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala
305                 310                 315                 320 
Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr
            340                 345                 350         
Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
        355                 360                 365             
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    370                 375                 380                 
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser
385                 390                 395                 400 
Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser
                405                 410                 415     
Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp
            420                 425                 430         
Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser
        435                 440                 445             
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
    450                 455                 460                 
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro
465                 470                 475                 480 
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 490             
