
                                SEQUENCE LISTING

<110> Icellhealth Consulting LLC
      SONG, XIAOTONG

<120> ONCOLYTIC VIRUS EXPRESSING BISPECIFIC
      ENGAGER MOLECULES

<130> 768312000140

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150> 62/385,933    
<151> 2016-09-09

<150> 62/385,930    
<151> 2016-09-09

<160> 91

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-H1

<400> 1
Ser Tyr Trp Met His
 1               5  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-H2

<400> 2
Glu Ile Asn Arg Ser Asn Gly Arg Ser Asn Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Ser
    


<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-H3

<400> 3
Gly Ala Thr Val Val Asp Tyr Tyr Ala Met Asp Tyr
 1               5                  10          


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-L1

<400> 4
Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His
 1               5                  10                  15  


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-L2

<400> 5
Tyr Ala Ser Asn Leu Glu Ser
 1               5          


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 HVR-L3

<400> 6
Gln His Ser Trp Glu Ile Pro Tyr Thr
 1               5                  


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-H1

<400> 7
Asn Tyr Gly Met Asn
 1               5  


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-H2

<400> 8
Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe Lys
 1               5                  10                  15      
Gly
    


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-H3

<400> 9
Phe Gly Tyr Ala Met Asp Tyr
 1               5          


<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-L1

<400> 10
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr
 1               5                  10                  15      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-L2

<400> 11
Gln Met Ser Asn Leu Ala Ser
 1               5          


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 HVR-L3

<400> 12
Ala Gln Asn Leu Glu Leu Pro Arg Thr
 1               5                  


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-H1

<400> 13
Asn Tyr Gly Met Asn
 1               5  


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-H2

<400> 14
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys
 1               5                  10                  15      
Gly
    


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-H3

<400> 15
Trp Gly Gly Asn Phe Asp Tyr
 1               5          


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-L1

<400> 16
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr
 1               5                  10                  15      


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-L2

<400> 17
Gln Met Ser Asn Leu Ala Ser
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 HVR-L3

<400> 18
Ala Gln Asn Leu Glu Leu Pro Arg Thr
 1               5                  


<210> 19
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 VH

<400> 19
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Arg Ser Asn Gly Arg Ser Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ala Thr Val Val Asp Tyr Tyr Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Leu Thr Val Ser Ser
        115                 120     


<210> 20
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 VL

<400> 20
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp
                85                  90                  95      
Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 21
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 VH

<400> 21
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Phe Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 22
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 VL

<400> 22
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
 1               5                  10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
                85                  90                  95      
Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 23
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 VH

<400> 23
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Trp Gly Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 24
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 VL

<400> 24
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
 1               5                  10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
                85                  90                  95      
Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H1

<400> 25
Glu Asn Ile Ile His
 1               5  


<210> 26
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H2

<400> 26
Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-H3

<400> 27
His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr
 1               5                  10      


<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-L1

<400> 28
Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His
 1               5                  10                  15  


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-L2

<400> 29
Leu Ala Ser Asn Leu Glu Ser
 1               5          


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP HVR-L3

<400> 30
Gln His Ser Arg Glu Leu Pro Tyr Thr
 1               5                  


<210> 31
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP VH

<400> 31
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 32
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP VL

<400> 32
Gln Ile Leu Met Thr Gln Ser Pro Ala Ser Ser Val Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
            20                  25                  30          
Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Pro
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         
Ala
    


<210> 33
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1C8E11 scFv

<400> 33
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Arg Ser Asn Gly Arg Ser Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ala Thr Val Val Asp Tyr Tyr Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro
    130                 135                 140                 
Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg
145                 150                 155                 160 
Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr
                165                 170                 175     
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser
            180                 185                 190         
Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
        195                 200                 205             
Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala
    210                 215                 220                 
Thr Tyr Tyr Cys Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gly
225                 230                 235                 240 
Gly Thr Lys Leu Glu Ile Lys
                245         


<210> 34
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3H8B6 scFv

<400> 34
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Phe Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
    130                 135                 140                 
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
145                 150                 155                 160 
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro
                165                 170                 175     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
        195                 200                 205             
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
    210                 215                 220                 
Ala Gln Asn Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys
            


<210> 35
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4A4D8 scFv

<400> 35
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Trp Gly Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
    130                 135                 140                 
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
145                 150                 155                 160 
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro
                165                 170                 175     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
        195                 200                 205             
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
    210                 215                 220                 
Ala Gln Asn Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys
            


<210> 36
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 scFv

<400> 36
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr
            100                 105                 110         
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
    130                 135                 140                 
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160 
Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                165                 170                 175     
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp
            180                 185                 190         
Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly
        195                 200                 205             
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
    210                 215                 220                 
Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr Thr Phe
225                 230                 235                 240 
Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser
                245                 250 


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-H1

<400> 37
Arg Tyr Thr Met His
 1               5  


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-H2

<400> 38
Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-H3

<400> 39
Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
 1               5                  10  


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-L1

<400> 40
Arg Ala Ser Ser Ser Val Ser Tyr Met Asn
 1               5                  10  


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-L2

<400> 41
Asp Thr Ser Lys Val Ala Ser
 1               5          


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 HVR-L3

<400> 42
Gln Gln Trp Ser Ser Asn Pro Leu Thr
 1               5                  


<210> 43
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 VH

<400> 43
Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 44
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 VL

<400> 44
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
            100                 105         


<210> 45
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> Homo sapiens CD3 scFv

<400> 45
Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile
    130                 135                 140                 
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser
145                 150                 155                 160 
Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser
                165                 170                 175     
Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro
            180                 185                 190         
Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile
        195                 200                 205             
Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
    210                 215                 220                 
Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
225                 230                 235                 240 
Ser
    


<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-VL linker amino acid sequence

<400> 46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-VL linker amino acid sequence

<400> 47
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala
 1               5                  10                  


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv-scFv linker amino acid sequence

<400> 48
Gly Gly Gly Gly Ser
 1               5  


<210> 49
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP scFv

<400> 49
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser Pro Ala Ser
    130                 135                 140                 
Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
145                 150                 155                 160 
Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln
                165                 170                 175     
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu
            180                 185                 190         
Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205             
Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
    210                 215                 220                 
Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg Ala
                245         


<210> 50
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR scFv

<400> 50
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala
            100                 105                 110         
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val
    130                 135                 140                 
Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys
145                 150                 155                 160 
Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Phe Ala Ser Trp Tyr
                165                 170                 175     
Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Met Tyr Ala Arg Asn
            180                 185                 190         
Asp Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
        195                 200                 205             
Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala
    210                 215                 220                 
Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu Phe
225                 230                 235                 240 
Gly Ala Gly Thr Lys Leu Thr Val Leu
                245                 


<210> 51
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM-CD3 and EGFR-CD3 signal peptide

<400> 51
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 52
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid encoding EpCAM-CD3 and EGFR-CD3 signal peptide

<400> 52
atgggatggt cctgtatcat tctgtttctg gtggctaccg caactggagt gcatagt    57

<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP-CD3 signal peptide

<400> 53
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly
 1               5                  10                  15      
Ala His Ser
            


<210> 54
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid encoding FAP-CD3 signal peptide

<400> 54
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattct    57

<210> 55
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM 1C8E11-Homo sapiens CD3 TE

<400> 55
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Arg Ser Asn Gly Arg Ser Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ala Thr Val Val Asp Tyr Tyr Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro
    130                 135                 140                 
Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg
145                 150                 155                 160 
Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr
                165                 170                 175     
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser
            180                 185                 190         
Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
        195                 200                 205             
Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala
    210                 215                 220                 
Thr Tyr Tyr Cys Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gly
225                 230                 235                 240 
Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Lys Leu
                245                 250                 255     
Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met
            260                 265                 270         
Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp
        275                 280                 285             
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn
    290                 295                 300                 
Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala
305                 310                 315                 320 
Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr
            340                 345                 350         
Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
        355                 360                 365             
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    370                 375                 380                 
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser
385                 390                 395                 400 
Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser
                405                 410                 415     
Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp
            420                 425                 430         
Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser
        435                 440                 445             
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
    450                 455                 460                 
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro
465                 470                 475                 480 
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 490             


<210> 56
<211> 489
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM 3H8B6-Homo sapiens CD3 TE

<400> 56
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Phe Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
    130                 135                 140                 
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
145                 150                 155                 160 
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro
                165                 170                 175     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
        195                 200                 205             
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
    210                 215                 220                 
Ala Gln Asn Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly
                245                 250                 255     
Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr
            260                 265                 270         
Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg
        275                 280                 285             
Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly
    290                 295                 300                 
Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr
305                 310                 315                 320 
Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser
                325                 330                 335     
Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr
            340                 345                 350         
Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly
        355                 360                 365             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    370                 375                 380                 
Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
385                 390                 395                 400 
Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp
                405                 410                 415     
Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
            420                 425                 430         
Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser
        435                 440                 445             
Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala
    450                 455                 460                 
Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly
465                 470                 475                 480 
Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 


<210> 57
<211> 489
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM 4A4D8-Homo sapiens CD3 TE

<400> 57
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Trp Gly Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
    130                 135                 140                 
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
145                 150                 155                 160 
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro
                165                 170                 175     
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
        195                 200                 205             
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
    210                 215                 220                 
Ala Gln Asn Leu Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly
                245                 250                 255     
Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr
            260                 265                 270         
Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg
        275                 280                 285             
Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly
    290                 295                 300                 
Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr
305                 310                 315                 320 
Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser
                325                 330                 335     
Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr
            340                 345                 350         
Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly
        355                 360                 365             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    370                 375                 380                 
Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
385                 390                 395                 400 
Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp
                405                 410                 415     
Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
            420                 425                 430         
Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser
        435                 440                 445             
Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala
    450                 455                 460                 
Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly
465                 470                 475                 480 
Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 


<210> 58
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM MT201-Homo sapiens CD3 TE

<400> 58
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr
            100                 105                 110         
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
    130                 135                 140                 
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160 
Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                165                 170                 175     
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp
            180                 185                 190         
Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly
        195                 200                 205             
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
    210                 215                 220                 
Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr Thr Phe
225                 230                 235                 240 
Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Asp
                245                 250                 255     
Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser
            260                 265                 270         
Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr
        275                 280                 285             
Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly
    290                 295                 300                 
Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys
305                 310                 315                 320 
Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met
                325                 330                 335     
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
            340                 345                 350         
Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr
        355                 360                 365             
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    370                 375                 380                 
Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met
385                 390                 395                 400 
Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser
                405                 410                 415     
Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro
            420                 425                 430         
Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr
        435                 440                 445             
Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
    450                 455                 460                 
Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
465                 470                 475                 480 
Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 490                 495     


<210> 59
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> FAP-Homo sapiens CD3 TE

<400> 59
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser Pro Ala Ser
    130                 135                 140                 
Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
145                 150                 155                 160 
Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln
                165                 170                 175     
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu
            180                 185                 190         
Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205             
Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
    210                 215                 220                 
Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu
                245                 250                 255     
Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met
            260                 265                 270         
Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp
        275                 280                 285             
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn
    290                 295                 300                 
Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala
305                 310                 315                 320 
Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr
            340                 345                 350         
Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
        355                 360                 365             
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    370                 375                 380                 
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser
385                 390                 395                 400 
Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser
                405                 410                 415     
Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp
            420                 425                 430         
Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser
        435                 440                 445             
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
    450                 455                 460                 
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro
465                 470                 475                 480 
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 490             


<210> 60
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 1C8E11 VH

<400> 60
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaggcagagg 120
cctggagaag gccttgagtg gattggagag attaatcgta gcaacggtcg ttctaactac 180
aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaggggct 300
acggtagtcg attactatgc tatggactac tggggtcaag gaacctcact caccgtctcc 360
tca                                                               363

<210> 61
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 1C8E11 VL

<400> 61
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc 60
atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac 120
caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct 180
ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac 300
acgttcggag gggggaccaa gctggaaata aaa                              333

<210> 62
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 3H8B6 VH

<400> 62
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gtcaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagatttggc 300
tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca              348

<210> 63
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 3H8B6 VL

<400> 63
gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60
atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg 120
tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180
tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc 240
agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttcct 300
cggacgttcg gtggaggcac caagctggaa atcaaa                           336

<210> 64
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 4A4D8 VH

<400> 64
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatgggga 300
ggtaactttg actactgggg ccaaggcacc actctcacag tctcctca              348

<210> 65
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 4A4D8 VL

<400> 65
gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60
atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg 120
tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180
tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc 240
agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttcct 300
cggacgttcg gtggaggcac caagctggaa atcaaa                           336

<210> 66
<211> 741
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 1C8E11 scFv

<400> 66
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaggcagagg 120
cctggagaag gccttgagtg gattggagag attaatcgta gcaacggtcg ttctaactac 180
aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaggggct 300
acggtagtcg attactatgc tatggactac tggggtcaag gaacctcact caccgtctcc 360
tcaggcggag gaggctccgg aggaggaggg tctggaggag gaggaagtga cattgtgctg 420
acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg 480
gccagccaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca 540
ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc 600
aggttcagtg gcagtgggtc tgggacagac ttcaccctca acatccatcc tgtggaggag 660
gaggatactg caacatatta ctgtcagcac agttgggaga ttccgtacac gttcggaggg 720
gggaccaagc tggaaataaa a                                           741

<210> 67
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 1C8E11 VH-VL-CD3 VH-VL

<400> 67
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaggcagagg 120
cctggagaag gccttgagtg gattggagag attaatcgta gcaacggtcg ttctaactac 180
aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaggggct 300
acggtagtcg attactatgc tatggactac tggggtcaag gaacctcact caccgtctcc 360
tcaggcggag gaggctccgg aggaggaggg tctggaggag gaggaagtga cattgtgctg 420
acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg 480
gccagccaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca 540
ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc 600
aggttcagtg gcagtgggtc tgggacagac ttcaccctca acatccatcc tgtggaggag 660
gaggatactg caacatatta ctgtcagcac agttgggaga ttccgtacac gttcggaggg 720
gggaccaagc tggaaataaa aggcggggga ggcgggagcg atattaaact gcagcagtct 780
ggagctgaac tggcacgacc tggcgcctcc gtgaaaatgt cttgtaagac tagtggctac 840
acattcactc gctataccat gcactgggtc aagcagcgac ctggacaggg cctggagtgg 900
atcgggtata ttaatccaag ccgcggatac accaactaca accagaagtt caaggacaag 960
gcaacactga ctaccgataa gagctcctct actgcctaca tgcagctgag ttcactgacc 1020
agtgaagact cagctgtgta ctattgcgca agatactatg acgatcatta ctgtctggat 1080
tattgggggc agggaacaac tctgactgtg agctccggag gaggaggaag cggaggagga 1140
ggcagcggag gaggcgggtc cgacatccag ctgacacaga gcccagcaat tatgtccgcc 1200
tctcccggcg agaaagtgac catgacatgc agggcctcta gttcagtctc ctacatgaat 1260
tggtaccagc agaaaagcgg gacatcccca aagcggtgga tctacgacac ttcaaaggtg 1320
gctagcggcg tcccctatag attttccggc tcagggagcg gcacctccta ctctctgact 1380
attagctcca tggaggcaga agatgcagcc acctactatt gtcagcagtg gtctagtaat 1440
ccactgactt ttggggcagg gactaaactg gaactgaaat ct                    1482

<210> 68
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 3H8B6 scFv

<400> 68
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gtcaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagatttggc 300
tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagg cggaggaggc 360
tccggaggag gagggtctgg aggaggagga agtgatattg tgatgacgca ggctgcattc 420
tccaatccag tcactcttgg aacatcagct tccatctcct gcaggtctag taagagtctc 480
ctacatagta atggcatcac ttatttgtat tggtatctgc agaagccagg ccagtctcct 540
cagctcctga tttatcagat gtccaacctt gcctcaggag tcccagacag gttcagtagc 600
agtgggtcag gaactgattt cacactgaga atcagcagag tggaggctga ggatgtgggt 660
gtttattact gtgctcaaaa tctagaactt cctcggacgt tcggtggagg caccaagctg 720
gaaatcaaa                                                         729

<210> 69
<211> 1470
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 3H8B6 VH-VL-CD3 VH-VL

<400> 69
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gtcaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagatttggc 300
tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagg cggaggaggc 360
tccggaggag gagggtctgg aggaggagga agtgatattg tgatgacgca ggctgcattc 420
tccaatccag tcactcttgg aacatcagct tccatctcct gcaggtctag taagagtctc 480
ctacatagta atggcatcac ttatttgtat tggtatctgc agaagccagg ccagtctcct 540
cagctcctga tttatcagat gtccaacctt gcctcaggag tcccagacag gttcagtagc 600
agtgggtcag gaactgattt cacactgaga atcagcagag tggaggctga ggatgtgggt 660
gtttattact gtgctcaaaa tctagaactt cctcggacgt tcggtggagg caccaagctg 720
gaaatcaaag gcgggggagg cgggagcgat attaaactgc agcagtctgg agctgaactg 780
gcacgacctg gcgcctccgt gaaaatgtct tgtaagacta gtggctacac attcactcgc 840
tataccatgc actgggtcaa gcagcgacct ggacagggcc tggagtggat cgggtatatt 900
aatccaagcc gcggatacac caactacaac cagaagttca aggacaaggc aacactgact 960
accgataaga gctcctctac tgcctacatg cagctgagtt cactgaccag tgaagactca 1020
gctgtgtact attgcgcaag atactatgac gatcattact gtctggatta ttgggggcag 1080
ggaacaactc tgactgtgag ctccggagga ggaggaagcg gaggaggagg cagcggagga 1140
ggcgggtccg acatccagct gacacagagc ccagcaatta tgtccgcctc tcccggcgag 1200
aaagtgacca tgacatgcag ggcctctagt tcagtctcct acatgaattg gtaccagcag 1260
aaaagcggga catccccaaa gcggtggatc tacgacactt caaaggtggc tagcggcgtc 1320
ccctatagat tttccggctc agggagcggc acctcctact ctctgactat tagctccatg 1380
gaggcagaag atgcagccac ctactattgt cagcagtggt ctagtaatcc actgactttt 1440
ggggcaggga ctaaactgga actgaaatct                                  1470

<210> 70
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 4A4D8 scFv

<400> 70
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatgggga 300
ggtaactttg actactgggg ccaaggcacc actctcacag tctcctcagg cggaggaggc 360
tccggaggag gagggtctgg aggaggagga agtgatattg tgatgacgca ggctgcattc 420
tccaatccag tcactcttgg aacatcagct tccatctcct gcaggtctag taagagtctc 480
ctacatagta atggcatcac ttatttgtat tggtatctgc agaagccagg ccagtctcct 540
cagctcctga tttatcagat gtccaacctt gcctcaggag tcccagacag gttcagtagc 600
agtgggtcag gaactgattt cacactgaga atcagcagag tggaggctga ggatgtgggt 660
gtttattact gtgctcaaaa tctagaactt cctcggacgt tcggtggagg caccaagctg 720
gaaatcaaa                                                         729

<210> 71
<211> 1470
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM 4A4D8 VH-VL-CD3 VH-VL

<400> 71
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat 180
gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatgggga 300
ggtaactttg actactgggg ccaaggcacc actctcacag tctcctcagg cggaggaggc 360
tccggaggag gagggtctgg aggaggagga agtgatattg tgatgacgca ggctgcattc 420
tccaatccag tcactcttgg aacatcagct tccatctcct gcaggtctag taagagtctc 480
ctacatagta atggcatcac ttatttgtat tggtatctgc agaagccagg ccagtctcct 540
cagctcctga tttatcagat gtccaacctt gcctcaggag tcccagacag gttcagtagc 600
agtgggtcag gaactgattt cacactgaga atcagcagag tggaggctga ggatgtgggt 660
gtttattact gtgctcaaaa tctagaactt cctcggacgt tcggtggagg caccaagctg 720
gaaatcaaag gcgggggagg cgggagcgat attaaactgc agcagtctgg agctgaactg 780
gcacgacctg gcgcctccgt gaaaatgtct tgtaagacta gtggctacac attcactcgc 840
tataccatgc actgggtcaa gcagcgacct ggacagggcc tggagtggat cgggtatatt 900
aatccaagcc gcggatacac caactacaac cagaagttca aggacaaggc aacactgact 960
accgataaga gctcctctac tgcctacatg cagctgagtt cactgaccag tgaagactca 1020
gctgtgtact attgcgcaag atactatgac gatcattact gtctggatta ttgggggcag 1080
ggaacaactc tgactgtgag ctccggagga ggaggaagcg gaggaggagg cagcggagga 1140
ggcgggtccg acatccagct gacacagagc ccagcaatta tgtccgcctc tcccggcgag 1200
aaagtgacca tgacatgcag ggcctctagt tcagtctcct acatgaattg gtaccagcag 1260
aaaagcggga catccccaaa gcggtggatc tacgacactt caaaggtggc tagcggcgtc 1320
ccctatagat tttccggctc agggagcggc acctcctact ctctgactat tagctccatg 1380
gaggcagaag atgcagccac ctactattgt cagcagtggt ctagtaatcc actgactttt 1440
ggggcaggga ctaaactgga actgaaatct                                  1470

<210> 72
<211> 1491
<212> DNA
<213> Artificial Sequence

<220> 
<223> EpCAM MT201 VH-VL-CD3 VH-VL

<400> 72
gaggtgcagc tgctggagag tggggggggc gtggtccagc ccggccggtc tctgagactg 60
agttgcgccg cttcaggctt cacctttagc tcctatggaa tgcactgggt gcgacaggca 120
cctggaaagg gcctggagtg ggtggctgtc atcagctacg acggctccaa caaatactat 180
gcagatagcg tgaaggggag gttcaccatt tctcgcgaca acagtaaaaa tacactgtac 240
ctgcagatga acagcctgag ggccgaagac accgctgtgt actattgcgc taaggatatg 300
ggatggggaa gcggatggcg accatactat tactatggca tggatgtctg ggggcaggga 360
accacagtga cagtctctag tggcggagga ggctccggag gaggagggtc tggaggagga 420
ggaagtgagc tgcagatgac ccagtcccca tcaagcctgt cagcaagcgt gggagaccga 480
gtcaccatca catgtcggac atcccagtct atttcctctt acctgaactg gtatcagcag 540
aaacctggac agccccctaa gctgctgatc tactgggcct caaccagaga gagcggcgtg 600
ccagacaggt tcagtggctc agggagcgga acagatttta ctctgaccat cagttcactg 660
cagcccgaag acagcgctac ttactattgc cagcagtcct acgatattcc ttatactttt 720
ggccagggga ccaaactgga gatcaagtct ggcgggggag gcgggagcga tattaaactg 780
cagcagtctg gagctgaact ggcacgacct ggcgcctccg tgaaaatgtc ttgtaagact 840
agtggctaca cattcactcg ctataccatg cactgggtca agcagcgacc tggacagggc 900
ctggagtgga tcgggtatat taatccaagc cgcggataca ccaactacaa ccagaagttc 960
aaggacaagg caacactgac taccgataag agctcctcta ctgcctacat gcagctgagt 1020
tcactgacca gtgaagactc agctgtgtac tattgcgcaa gatactatga cgatcattac 1080
tgtctggatt attgggggca gggaacaact ctgactgtga gctccggagg aggaggaagc 1140
ggaggaggag gcagcggagg aggcgggtcc gacatccagc tgacacagag cccagcaatt 1200
atgtccgcct ctcccggcga gaaagtgacc atgacatgca gggcctctag ttcagtctcc 1260
tacatgaatt ggtaccagca gaaaagcggg acatccccaa agcggtggat ctacgacact 1320
tcaaaggtgg ctagcggcgt cccctataga ttttccggct cagggagcgg cacctcctac 1380
tctctgacta ttagctccat ggaggcagaa gatgcagcca cctactattg tcagcagtgg 1440
tctagtaatc cactgacttt tggggcaggg actaaactgg aactgaaatc t          1491

<210> 73
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> FAP VH-VL-Homo sapiens CD3 VH-VL

<400> 73
caggtgcagc tgaagcagtc tggagctgaa ctggtgaaac ccggggcatc agtgaagctg 60
tcctgcaaga cttctggcta caccttcact gaaaatatta tacactgggt aaagcagagg 120
tctgggcagg gtcttgagtg gattgggtgg tttcaccctg gaagtggtag tataaagtac 180
aatgagaaat tcaaggacaa ggccacattg actgcggaca aatcctccag cacagtctat 240
atggagctta gtagattgac atctgaagac tctgcggtct atttctgtgc aagacacgga 300
ggaactgggc gaggagctat ggactactgg ggtcaaggaa cctcagtcac cgtctcgagt 360
ggtggaggcg gttcaggcgg aggtggctct ggcggtagtg cacaaattct gatgacccag 420
tctcctgctt cctcagttgt atctctgggg cagagggcca ccatctcatg cagggccagc 480
aaaagtgtca gtacatctgc ctatagttat atgcactggt accaacagaa accaggacag 540
ccacccaaac tcctcatcta tcttgcatcc aacctagaat ctggggtccc tcccaggttc 600
agtggcagtg ggtctgggac agacttcacc ctcaacatcc accctgtgga ggaggaggat 660
gctgcaacct attactgtca gcacagtagg gagcttccgt acacgttcgg aggggggacc 720
aagctggaaa taaaacgggc gggcggggga ggctcagtcg acgatatcaa gctgcagcag 780
tctggagcag agctggctag accaggagca tcagtgaaaa tgagctgtaa gacctccggc 840
tatacattca ctcgctacac aatgcactgg gtgaagcagc gacctgggca gggactggaa 900
tggatcgggt acattaatcc aagcagggga tacaccaact acaaccagaa gtttaaagac 960
aaggctactc tgactaccga taagtcaagc tccaccgcat acatgcagct gtctagtctg 1020
acatcagagg acagcgccgt gtactattgc gctcgctact atgacgatca ttattgtctg 1080
gattattggg gacaggggac aactctgaca gtgtcaagcg gaggaggagg aagcggagga 1140
ggcggctccg gcggaggagg ctctgacatc cagctgactc agtctcccgc cattatgtca 1200
gcttcccctg gcgaaaaagt gaccatgaca tgccgggcct cctctagtgt cagctatatg 1260
aactggtacc agcagaaatc cgggacttct ccaaagcgat ggatctatga cacctctaag 1320
gtggctagtg gagtccccta ccggttctcc ggatctggca gtgggacttc atatagcctg 1380
accatttcaa gcatggaggc cgaagatgct gcaacctact attgtcagca gtggtcctct 1440
aatcccctga ccttcggggc tgggactaaa ctggaactga aatcatga              1488

<210> 74
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR-CD3 TE

<400> 74
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala
            100                 105                 110         
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val
    130                 135                 140                 
Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys
145                 150                 155                 160 
Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Phe Ala Ser Trp Tyr
                165                 170                 175     
Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Met Tyr Ala Arg Asn
            180                 185                 190         
Asp Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
        195                 200                 205             
Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala
    210                 215                 220                 
Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu Phe
225                 230                 235                 240 
Gly Ala Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Asp Ile
                245                 250                 255     
Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val
            260                 265                 270         
Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met
        275                 280                 285             
His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr
    290                 295                 300                 
Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp
305                 310                 315                 320 
Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln
                325                 330                 335     
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg
            340                 345                 350         
Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr
        355                 360                 365             
Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    370                 375                 380                 
Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser
385                 390                 395                 400 
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser
                405                 410                 415     
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
            420                 425                 430         
Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg
        435                 440                 445             
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser
    450                 455                 460                 
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
465                 470                 475                 480 
Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser
                485                 490                 495 


<210> 75
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> EGFR VH-VL-CD3 VH-VL

<400> 75
gaggtgcagc tggtccagag cggggcagaa gtgaaaaagc ctgggtcatc cgtgaaagtg 60
tcctgtaaag caagcggcgg cacatttagc tcctacgcca tctcctgggt gcggcaggca 120
cctggacagg gcctggagtg gatgggagga atcatcccaa tcttcggcac cgccaactac 180
gcccagaagt ttcagggcag agtgaccatc acagccgacg agtctaccag cacagcctat 240
atggagctgt ctagcctgag gtctgaggat accgccgtgt actattgcgc ccgcgaggag 300
ggaccatact gctcctctac aagctgttat ggagccttcg acatctgggg acagggcacc 360
ctggtgaccg tgagcagcgg aggaggaggc agcggaggag gaggctccgg cggcggcggc 420
tcccagtctg tgctgacaca ggaccctgcc gtgtccgtgg ccctgggaca gaccgtgaag 480
atcacatgcc agggcgattc tctgaggagc tacttcgcca gctggtatca gcagaagcca 540
ggacaggcac ccaccctggt catgtatgca aggaatgaca gaccagccgg cgtgcccgat 600
cggttcagcg gctccaagtc tggcacaagc gcctccctgg ccatctccgg actgcagtct 660
gaggacgagg ccgattacta ttgtgccgcc tgggacgact cactgaatgg atacctgttc 720
ggggctggga ctaaactgac cgtgctgggc gggggaggcg ggagcgatat taaactgcag 780
cagtctggag ctgaactggc acgacctggc gcctccgtga aaatgtcttg taagactagt 840
ggctacacat tcactcgcta taccatgcac tgggtcaagc agcgacctgg acagggcctg 900
gagtggatcg ggtatattaa tccaagccgc ggatacacca actacaacca gaagttcaag 960
gacaaggcaa cactgactac cgataagagc tcctctactg cctacatgca gctgagttca 1020
ctgaccagtg aagactcagc tgtgtactat tgcgcaagat actatgacga tcattactgt 1080
ctggattatt gggggcaggg aacaactctg actgtgagct ccggaggagg aggaagcgga 1140
ggaggaggca gcggaggagg cgggtccgac atccagctga cacagagccc agcaattatg 1200
tccgcctctc ccggcgagaa agtgaccatg acatgcaggg cctctagttc agtctcctac 1260
atgaattggt accagcagaa aagcgggaca tccccaaagc ggtggatcta cgacacttca 1320
aaggtggcta gcggcgtccc ctatagattt tccggctcag ggagcggcac ctcctactct 1380
ctgactatta gctccatgga ggcagaagat gcagccacct actattgtca gcagtggtct 1440
agtaatccac tgacttttgg ggcagggact aaactggaac tgaaatct              1488

<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-H1

<400> 76
Gly Phe Thr Phe Ser Ser Tyr Gly
 1               5              


<210> 77
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-H2

<400> 77
Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 78
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-H3

<400> 78
Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr Gly Met
 1               5                  10                  15      
Asp Val
        


<210> 79
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-L1

<400> 79
Arg Thr Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10      


<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-L2

<400> 80
Tyr Trp Ala Ser Thr Arg Glu Ser
 1               5              


<210> 81
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 HVR-L3

<400> 81
Gln Gln Ser Tyr Asp Ile Pro Tyr Thr
 1               5                  


<210> 82
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 VH

<400> 82
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr
            100                 105                 110         
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125         


<210> 83
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> MT201 VL

<400> 83
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser
            100                 105             


<210> 84
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-H1

<400> 84
Ser Tyr Ala Ile Ser
 1               5  


<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-H2

<400> 85
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    


<210> 86
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-H3

<400> 86
Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala Phe Asp
 1               5                  10                  15      
Ile
    


<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-L1

<400> 87
Gln Gly Asp Ser Leu Arg Ser Tyr Phe Ala Ser
 1               5                  10      


<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-L2

<400> 88
Ala Arg Asn Asp Arg Pro Ala
 1               5          


<210> 89
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR HVR-L3

<400> 89
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu
 1               5                  10      


<210> 90
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR VH

<400> 90
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Glu Gly Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala
            100                 105                 110         
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 91
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR VL

<400> 91
Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
 1               5                  10                  15      
Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Phe Ala
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Val Met Tyr
        35                  40                  45              
Ala Arg Asn Asp Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly
                85                  90                  95      
Tyr Leu Phe Gly Ala Gly Thr Lys Leu Thr Val Leu
            100                 105             

