                         SEQUENCE LISTING

<110>  IncellDx, Inc.
       Patterson, Bruce  K.
       Chargin, Amanda  Noel
       Shults, Keith
 
<120>  METHODS OF DETECTING PER CELL PD-L1 EXPRESSION AND USES THEREOF

<130>  ICDX-011WO

<140>  PCT US2017/050322
<141>  2017-09-06

<150>  US 62/384,037
<151>  2016-09-06

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  2
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
65                  70                  75                  80  


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
                165                 170                 175     


<210>  3
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc      180

aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta      240

gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt      300

attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg      360

gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg      420

aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag      480

cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg      540

gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa      600

gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc      660

aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat      720

gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg      780

gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg      840

ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg      900

agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat      960

acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc     1020

aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg     1080

ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc     1140

agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac     1200

tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca     1260

aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa     1320

tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt     1380

ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta     1440

tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt     1500

gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga     1560

tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta     1620

caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt     1680

taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt     1740

atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat     1800

ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga     1860

ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac     1920

ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc     1980

aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca     2040

gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac     2100

aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa     2160

aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata     2220

tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa     2280

ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc     2340

ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc     2400

ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa     2460

agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc     2520

tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt     2580

tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg     2640

tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg     2700

aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt     2760

cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata     2820

catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat     2880

gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa     2940

aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct     3000

ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg     3060

aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg     3120

tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc     3180

tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca     3240

tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac     3300

agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt     3360

ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata     3420

gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac     3480

tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc     3540

tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt     3600

gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca     3660

gtttaacatc ccagtggaga aagttaaaaa a                                    3691


<210>  4
<211>  3349
<212>  DNA
<213>  Homo sapiens

<400>  4
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg ccccatacaa caaaatcaac      180

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      240

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      300

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      360

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      420

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      480

actcacttgg taattctggg agccatctta ttatgccttg gtgtagcact gacattcatc      540

ttccgtttaa gaaaagggag aatgatggat gtgaaaaaat gtggcatcca agatacaaac      600

tcaaagaagc aaagtgatac acatttggag gagacgtaat ccagcattgg aacttctgat      660

cttcaagcag ggattctcaa cctgtggttt aggggttcat cggggctgag cgtgacaaga      720

ggaaggaatg ggcccgtggg atgcaggcaa tgtgggactt aaaaggccca agcactgaaa      780

atggaacctg gcgaaagcag aggaggagaa tgaagaaaga tggagtcaaa cagggagcct      840

ggagggagac cttgatactt tcaaatgcct gaggggctca tcgacgcctg tgacagggag      900

aaaggatact tctgaacaag gagcctccaa gcaaatcatc cattgctcat cctaggaaga      960

cgggttgaga atccctaatt tgagggtcag ttcctgcaga agtgcccttt gcctccactc     1020

aatgcctcaa tttgttttct gcatgactga gagtctcagt gttggaacgg gacagtattt     1080

atgtatgagt ttttcctatt tattttgagt ctgtgaggtc ttcttgtcat gtgagtgtgg     1140

ttgtgaatga tttcttttga agatatattg tagtagatgt tacaattttg tcgccaaact     1200

aaacttgctg cttaatgatt tgctcacatc tagtaaaaca tggagtattt gtaaggtgct     1260

tggtctcctc tataactaca agtatacatt ggaagcataa agatcaaacc gttggttgca     1320

taggatgtca cctttattta acccattaat actctggttg acctaatctt attctcagac     1380

ctcaagtgtc tgtgcagtat ctgttccatt taaatatcag ctttacaatt atgtggtagc     1440

ctacacacat aatctcattt catcgctgta accaccctgt tgtgataacc actattattt     1500

tacccatcgt acagctgagg aagcaaacag attaagtaac ttgcccaaac cagtaaatag     1560

cagacctcag actgccaccc actgtccttt tataatacaa tttacagcta tattttactt     1620

taagcaattc ttttattcaa aaaccattta ttaagtgccc ttgcaatatc aatcgctgtg     1680

ccaggcattg aatctacaga tgtgagcaag acaaagtacc tgtcctcaag gagctcatag     1740

tataatgagg agattaacaa gaaaatgtat tattacaatt tagtccagtg tcatagcata     1800

aggatgatgc gaggggaaaa cccgagcagt gttgccaaga ggaggaaata ggccaatgtg     1860

gtctgggacg gttggatata cttaaacatc ttaataatca gagtaatttt catttacaaa     1920

gagaggtcgg tacttaaaat aaccctgaaa aataacactg gaattccttt tctagcatta     1980

tatttattcc tgatttgcct ttgccatata atctaatgct tgtttatata gtgtctggta     2040

ttgtttaaca gttctgtctt ttctatttaa atgccactaa attttaaatt catacctttc     2100

catgattcaa aattcaaaag atcccatggg agatggttgg aaaatctcca cttcatcctc     2160

caagccattc aagtttcctt tccagaagca actgctactg cctttcattc atatgttctt     2220

ctaaagatag tctacatttg gaaatgtatg ttaaaagcac gtatttttaa aatttttttc     2280

ctaaatagta acacattgta tgtctgctgt gtactttgct atttttattt attttagtgt     2340

ttcttatata gcagatggaa tgaatttgaa gttcccaggg ctgaggatcc atgccttctt     2400

tgtttctaag ttatctttcc catagctttt cattatcttt catatgatcc agtatatgtt     2460

aaatatgtcc tacatataca tttagacaac caccatttgt taagtatttg ctctaggaca     2520

gagtttggat ttgtttatgt ttgctcaaaa ggagacccat gggctctcca gggtgcactg     2580

agtcaatcta gtcctaaaaa gcaatcttat tattaactct gtatgacaga atcatgtctg     2640

gaacttttgt tttctgcttt ctgtcaagta taaacttcac tttgatgctg tacttgcaaa     2700

atcacatttt ctttctggaa attccggcag tgtaccttga ctgctagcta ccctgtgcca     2760

gaaaagcctc attcgttgtg cttgaaccct tgaatgccac cagctgtcat cactacacag     2820

ccctcctaag aggcttcctg gaggtttcga gattcagatg ccctgggaga tcccagagtt     2880

tcctttccct cttggccata ttctggtgtc aatgacaagg agtaccttgg ctttgccaca     2940

tgtcaaggct gaagaaacag tgtctccaac agagctcctt gtgttatctg tttgtacatg     3000

tgcatttgta cagtaattgg tgtgacagtg ttctttgtgt gaattacagg caagaattgt     3060

ggctgagcaa ggcacatagt ctactcagtc tattcctaag tcctaactcc tccttgtggt     3120

gttggatttg taaggcactt tatccctttt gtctcatgtt tcatcgtaaa tggcataggc     3180

agagatgata cctaattctg catttgattg tcactttttg tacctgcatt aatttaataa     3240

aatattctta tttattttgt tacttggtac accagcatgt ccattttctt gtttattttg     3300

tgtttaataa aatgttcagt ttaacatccc agtggagaaa gttaaaaaa                 3349


