                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> TOPICAL TRPV1 ANTAGONISTS AND METHODS AND COMPOSITIONS THEREOF

<130> 701039-087771-PCT

<140>
<141>

<150> 62/383,713
<151> 2016-09-06

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 839
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Lys Trp Ser Ser Thr Asp Leu Gly Ala Ala Ala Asp Pro Leu 
1               5                   10                  15      


Gln Lys Asp Thr Cys Pro Asp Pro Leu Asp Gly Asp Pro Asn Ser Arg 
            20                  25                  30          


Pro Pro Pro Ala Lys Pro Gln Leu Ser Thr Ala Lys Ser Arg Thr Arg 
        35                  40                  45              


Leu Phe Gly Lys Gly Asp Ser Glu Glu Ala Phe Pro Val Asp Cys Pro 
    50                  55                  60                  


His Glu Glu Gly Glu Leu Asp Ser Cys Pro Thr Ile Thr Val Ser Pro 
65                  70                  75                  80  


Val Ile Thr Ile Gln Arg Pro Gly Asp Gly Pro Thr Gly Ala Arg Leu 
                85                  90                  95      


Leu Ser Gln Asp Ser Val Ala Ala Ser Thr Glu Lys Thr Leu Arg Leu 
            100                 105                 110         


Tyr Asp Arg Arg Ser Ile Phe Glu Ala Val Ala Gln Asn Asn Cys Gln 
        115                 120                 125             


Asp Leu Glu Ser Leu Leu Leu Phe Leu Gln Lys Ser Lys Lys His Leu 
    130                 135                 140                 


Thr Asp Asn Glu Phe Lys Asp Pro Glu Thr Gly Lys Thr Cys Leu Leu 
145                 150                 155                 160 


Lys Ala Met Leu Asn Leu His Asp Gly Gln Asn Thr Thr Ile Pro Leu 
                165                 170                 175     


Leu Leu Glu Ile Ala Arg Gln Thr Asp Ser Leu Lys Glu Leu Val Asn 
            180                 185                 190         


Ala Ser Tyr Thr Asp Ser Tyr Tyr Lys Gly Gln Thr Ala Leu His Ile 
        195                 200                 205             


Ala Ile Glu Arg Arg Asn Met Ala Leu Val Thr Leu Leu Val Glu Asn 
    210                 215                 220                 


Gly Ala Asp Val Gln Ala Ala Ala His Gly Asp Phe Phe Lys Lys Thr 
225                 230                 235                 240 


Lys Gly Arg Pro Gly Phe Tyr Phe Gly Glu Leu Pro Leu Ser Leu Ala 
                245                 250                 255     


Ala Cys Thr Asn Gln Leu Gly Ile Val Lys Phe Leu Leu Gln Asn Ser 
            260                 265                 270         


Trp Gln Thr Ala Asp Ile Ser Ala Arg Asp Ser Val Gly Asn Thr Val 
        275                 280                 285             


Leu His Ala Leu Val Glu Val Ala Asp Asn Thr Ala Asp Asn Thr Lys 
    290                 295                 300                 


Phe Val Thr Ser Met Tyr Asn Glu Ile Leu Met Leu Gly Ala Lys Leu 
305                 310                 315                 320 


His Pro Thr Leu Lys Leu Glu Glu Leu Thr Asn Lys Lys Gly Met Thr 
                325                 330                 335     


Pro Leu Ala Leu Ala Ala Gly Thr Gly Lys Ile Gly Val Leu Ala Tyr 
            340                 345                 350         


Ile Leu Gln Arg Glu Ile Gln Glu Pro Glu Cys Arg His Leu Ser Arg 
        355                 360                 365             


Lys Phe Thr Glu Trp Ala Tyr Gly Pro Val His Ser Ser Leu Tyr Asp 
    370                 375                 380                 


Leu Ser Cys Ile Asp Thr Cys Glu Lys Asn Ser Val Leu Glu Val Ile 
385                 390                 395                 400 


Ala Tyr Ser Ser Ser Glu Thr Pro Asn Arg His Asp Met Leu Leu Val 
                405                 410                 415     


Glu Pro Leu Asn Arg Leu Leu Gln Asp Lys Trp Asp Arg Phe Val Lys 
            420                 425                 430         


Arg Ile Phe Tyr Phe Asn Phe Leu Val Tyr Cys Leu Tyr Met Ile Ile 
        435                 440                 445             


Phe Thr Met Ala Ala Tyr Tyr Arg Pro Val Asp Gly Leu Pro Pro Phe 
    450                 455                 460                 


Lys Met Glu Lys Thr Gly Asp Tyr Phe Arg Val Thr Gly Glu Ile Leu 
465                 470                 475                 480 


Ser Val Leu Gly Gly Val Tyr Phe Phe Phe Arg Gly Ile Gln Tyr Phe 
                485                 490                 495     


Leu Gln Arg Arg Pro Ser Met Lys Thr Leu Phe Val Asp Ser Tyr Ser 
            500                 505                 510         


Glu Met Leu Phe Phe Leu Gln Ser Leu Phe Met Leu Ala Thr Val Val 
        515                 520                 525             


Leu Tyr Phe Ser His Leu Lys Glu Tyr Val Ala Ser Met Val Phe Ser 
    530                 535                 540                 


Leu Ala Leu Gly Trp Thr Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln 
545                 550                 555                 560 


Gln Met Gly Ile Tyr Ala Val Met Ile Glu Lys Met Ile Leu Arg Asp 
                565                 570                 575     


Leu Cys Arg Phe Met Phe Val Tyr Ile Val Phe Leu Phe Gly Phe Ser 
            580                 585                 590         


Thr Ala Val Val Thr Leu Ile Glu Asp Gly Lys Asn Asp Ser Leu Pro 
        595                 600                 605             


Ser Glu Ser Thr Ser His Arg Trp Arg Gly Pro Ala Cys Arg Pro Pro 
    610                 615                 620                 


Asp Ser Ser Tyr Asn Ser Leu Tyr Ser Thr Cys Leu Glu Leu Phe Lys 
625                 630                 635                 640 


Phe Thr Ile Gly Met Gly Asp Leu Glu Phe Thr Glu Asn Tyr Asp Phe 
                645                 650                 655     


Lys Ala Val Phe Ile Ile Leu Leu Leu Ala Tyr Val Ile Leu Thr Tyr 
            660                 665                 670         


Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Met Gly Glu Thr Val Asn 
        675                 680                 685             


Lys Ile Ala Gln Glu Ser Lys Asn Ile Trp Lys Leu Gln Arg Ala Ile 
    690                 695                 700                 


Thr Ile Leu Asp Thr Glu Lys Ser Phe Leu Lys Cys Met Arg Lys Ala 
705                 710                 715                 720 


Phe Arg Ser Gly Lys Leu Leu Gln Val Gly Tyr Thr Pro Asp Gly Lys 
                725                 730                 735     


Asp Asp Tyr Arg Trp Cys Phe Arg Val Asp Glu Val Asn Trp Thr Thr 
            740                 745                 750         


Trp Asn Thr Asn Val Gly Ile Ile Asn Glu Asp Pro Gly Asn Cys Glu 
        755                 760                 765             


Gly Val Lys Arg Thr Leu Ser Phe Ser Leu Arg Ser Ser Arg Val Ser 
    770                 775                 780                 


Gly Arg His Trp Lys Asn Phe Ala Leu Val Pro Leu Leu Arg Glu Ala 
785                 790                 795                 800 


Ser Ala Arg Asp Arg Gln Ser Ala Gln Pro Glu Glu Val Tyr Leu Arg 
                805                 810                 815     


Gln Phe Ser Gly Ser Leu Lys Pro Glu Asp Ala Glu Val Phe Lys Ser 
            820                 825                 830         


Pro Ala Ala Ser Gly Glu Lys 
        835                 


<210> 2
<211> 1119
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens

<400> 3
Gln Arg Phe Ser Arg 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Rattus norvegicus

<400> 4
Gln His Asn Pro Arg 
1               5   


<210> 5
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      SMR3 peptide

<400> 5
Gln Arg Gly Pro Arg 
1               5   


