                         SEQUENCE LISTING

<110>  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW 
       UNIVERSITY OF JERUSALEM LTD.
       UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
       MANDELBOIM, Ofer
       JONJIC, Stipan
       BERHANI, Orit
       GLASNER, Ariella
 
<120>  ANTI-NKP46 ANTIBODIES AND THERAPEUTIC USE OF SAME

<130>  70155

<150>  US 62/384,267
<151>  2016-09-07

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain: NA sequence

<400>  1
atgggcaggc ttacttcttc attcctgcta ctgattgttc ctgcatatgt cctctcccag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgttctttct ctgggttttc actgagcact tatggtatag gagtaggctg gaatcgtcag      180

ccttcaggga agggtctgga gtggctggca cacatttggt ggaatgataa tgagtactat      240

aacatagacc tgaagagccg gctcacaatc tccaaggata cctccaacaa ccaggtattc      300

ctcaagatcg ccagtgtgga cactgcagat actgccacat actactgtgt tcgaggaaac      360

tataggtacg cgagggggta tgttatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa      480

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      540

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag      600

tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag      660

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      720

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      780

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      840

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      900

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      960

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc     1020

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1080

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1140

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     1200

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     1260

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1320

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1380

tcccactctc ctggtaaatg a                                               1401


<210>  2
<211>  466
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain: AA sequence

<400>  2

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Tyr Gly Ile Gly Val Gly Trp Asn Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asn Asp Asn Glu Tyr Tyr 
65                  70                  75                  80  


Asn Ile Asp Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Val Arg Gly Asn Tyr Arg Tyr Ala Arg Gly Tyr Val 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
145                 150                 155                 160 


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val 
225                 230                 235                 240 


Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
                245                 250                 255     


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
            260                 265                 270         


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
    290                 295                 300                 


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
        355                 360                 365             


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
    370                 375                 380                 


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
385                 390                 395                 400 


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
                405                 410                 415     


Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
            420                 425                 430         


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
        435                 440                 445             


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR1: NA sequence

<400>  3
acttatggta taggagtagg c                                                 21


<210>  4
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR1: AA sequence

<400>  4

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  5
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR2: NA sequence

<400>  5
cacatttggt ggaatgataa tgagtactat aacatagacc tgaagagc                    48


<210>  6
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR2: AA sequence

<400>  6

His Ile Trp Trp Asn Asp Asn Glu Tyr Tyr Asn Ile Asp Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR3: NA sequence

<400>  7
ggaaactata ggtacgcgag ggggtatgtt atggactac                              39


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Heavy chain CDR3: AA sequence

<400>  8

Gly Asn Tyr Arg Tyr Ala Arg Gly Tyr Val Met Asp Tyr 
1               5                   10              


<210>  9
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain: NA sequence

<400>  9
atggagtcag acacactcct gctatgggtg ctgctgctct gggttccagg ctccactggt       60

gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc      120

atctcctgca gagccagtga aagtgttgaa tattatggca caagtttaat gcagtggtac      180

caacaaaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      300

cctgtggagg aggatgattt tgcaatgtat ttctgtcagc aaaataggaa ggttccttgg      360

acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag         717


<210>  10
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain: AA sequence

<400>  10

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Asp Asp Phe Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Asn Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  11
<211>  5
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR1: NA sequence

<400>  11
agagc                                                                    5


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR1: AA sequence

<400>  12

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR2: NA sequence

<400>  13
gctgcatcca acgtagaatc t                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR2: AA sequence

<400>  14

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR3: NA sequence

<400>  15
cagcaaaata ggaaggttcc ttggacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hNKp46.02 mAb - Light chain CDR3: AA sequence

<400>  16

Gln Gln Asn Arg Lys Val Pro Trp Thr 
1               5                   


