                         SEQUENCE LISTING

<110>  GENETHON et al.
 
<120>  ACID-ALPHA GLUCOSIDASE VARIANTS AND USES THEREOF

<130>  B2299PC00

<160>  53    

<170>  PatentIn version 3.3

<210>  1
<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  hGAAwt w/o sp

<400>  1

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  2
<211>  952
<212>  PRT
<213>  homo sapiens

<400>  2

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  3
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  sp7

<400>  3

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  4
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  sp1

<400>  4

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu 
            20                  25          


<210>  5
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  sp2

<400>  5

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  6
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  sp6

<400>  6

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly 
            20                  25  


<210>  7
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  sp8

<400>  7

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser 
            20          


<210>  8
<211>  2859
<212>  DNA
<213>  homo sapiens

<400>  8
atgggagtga ggcacccgcc ctgctcccac cggctcctgg ccgtctgcgc cctcgtgtcc     60

ttggcaaccg cagcgctcct ggggcacatc ctactccatg atttcctgct ggttccccga    120

gagctgagtg gctcctcccc agtcctggag gagactcacc cagctcacca gcagggagcc    180

agcagaccag ggccccggga tgcccaggca caccccgggc ggccgcgagc agtgcccaca    240

cagtgcgacg tcccccccaa cagccgcttc gattgcgccc ctgacaaggc catcacccag    300

gaacagtgcg aggcccgcgg ctgttgctac atccctgcaa agcaggggct gcagggagcc    360

cagatggggc agccctggtg cttcttccca cccagctacc ccagctacaa gctggagaac    420

ctgagctcct ctgaaatggg ctacacggcc accctgaccc gtaccacccc caccttcttc    480

cccaaggaca tcctgaccct gcggctggac gtgatgatgg agactgagaa ccgcctccac    540

ttcacgatca aagatccagc taacaggcgc tacgaggtgc ccttggagac cccgcatgtc    600

cacagccggg caccgtcccc actctacagc gtggagttct ccgaggagcc cttcggggtg    660

atcgtgcgcc ggcagctgga cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc    720

tttgcggacc agttccttca gctgtccacc tcgctgccct cgcagtatat cacaggcctc    780

gccgagcacc tcagtcccct gatgctcagc accagctgga ccaggatcac cctgtggaac    840

cgggaccttg cgcccacgcc cggtgcgaac ctctacgggt ctcacccttt ctacctggcg    900

ctggaggacg gcgggtcggc acacggggtg ttcctgctaa acagcaatgc catggatgtg    960

gtcctgcagc cgagccctgc ccttagctgg aggtcgacag gtgggatcct ggatgtctac   1020

atcttcctgg gcccagagcc caagagcgtg gtgcagcagt acctggacgt tgtgggatac   1080

ccgttcatgc cgccatactg gggcctgggc ttccacctgt gccgctgggg ctactcctcc   1140

accgctatca cccgccaggt ggtggagaac atgaccaggg cccacttccc cctggacgtc   1200

cagtggaacg acctggacta catggactcc cggagggact tcacgttcaa caaggatggc   1260

ttccgggact tcccggccat ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg   1320

atcgtggatc ctgccatcag cagctcgggc cctgccggga gctacaggcc ctacgacgag   1380

ggtctgcgga ggggggtttt catcaccaac gagaccggcc agccgctgat tgggaaggta   1440

tggcccgggt ccactgcctt ccccgacttc accaacccca cagccctggc ctggtgggag   1500

gacatggtgg ctgagttcca tgaccaggtg cccttcgacg gcatgtggat tgacatgaac   1560

gagccttcca acttcatcag gggctctgag gacggctgcc ccaacaatga gctggagaac   1620

ccaccctacg tgcctggggt ggttgggggg accctccagg cggccaccat ctgtgcctcc   1680

agccaccagt ttctctccac acactacaac ctgcacaacc tctacggcct gaccgaagcc   1740

atcgcctccc acagggcgct ggtgaaggct cgggggacac gcccatttgt gatctcccgc   1800

tcgacctttg ctggccacgg ccgatacgcc ggccactgga cgggggacgt gtggagctcc   1860

tgggagcagc tcgcctcctc cgtgccagaa atcctgcagt ttaacctgct gggggtgcct   1920

ctggtcgggg ccgacgtctg cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc   1980

tggacccagc tgggggcctt ctaccccttc atgcggaacc acaacagcct gctcagtctg   2040

ccccaggagc cgtacagctt cagcgagccg gcccagcagg ccatgaggaa ggccctcacc   2100

ctgcgctacg cactcctccc ccacctctac acactgttcc accaggccca cgtcgcgggg   2160

gagaccgtgg cccggcccct cttcctggag ttccccaagg actctagcac ctggactgtg   2220

gaccaccagc tcctgtgggg ggaggccctg ctcatcaccc cagtgctcca ggccgggaag   2280

gccgaagtga ctggctactt ccccttgggc acatggtacg acctgcagac ggtgccagta   2340

gaggcccttg gcagcctccc acccccacct gcagctcccc gtgagccagc catccacagc   2400

gaggggcagt gggtgacgct gccggccccc ctggacacca tcaacgtcca cctccgggct   2460

gggtacatca tccccctgca gggccctggc ctcacaacca cagagtcccg ccagcagccc   2520

atggccctgg ctgtggccct gaccaagggt ggggaggccc gaggggagct gttctgggac   2580

gatggagaga gcctggaagt gctggagcga ggggcctaca cacaggtcat cttcctggcc   2640

aggaataaca cgatcgtgaa tgagctggta cgtgtgacca gtgagggagc tggcctgcag   2700

ctgcagaagg tgactgtcct gggcgtggcc acggcgcccc agcaggtcct ctccaacggt   2760

gtccctgtct ccaacttcac ctacagcccc gacaccaagg tcctggacat ctgtgtctcg   2820

ctgttgatgg gagagcagtt tctcgtcagc tggtgttag                          2859


<210>  9
<211>  2778
<212>  DNA
<213>  artificial

<220>
<223>  hGAAwt w/o sp

<400>  9
gggcacatcc tactccatga tttcctgctg gttccccgag agctgagtgg ctcctcccca     60

gtcctggagg agactcaccc agctcaccag cagggagcca gcagaccagg gccccgggat    120

gcccaggcac accccgggcg gccgcgagca gtgcccacac agtgcgacgt cccccccaac    180

agccgcttcg attgcgcccc tgacaaggcc atcacccagg aacagtgcga ggcccgcggc    240

tgttgctaca tccctgcaaa gcaggggctg cagggagccc agatggggca gccctggtgc    300

ttcttcccac ccagctaccc cagctacaag ctggagaacc tgagctcctc tgaaatgggc    360

tacacggcca ccctgacccg taccaccccc accttcttcc ccaaggacat cctgaccctg    420

cggctggacg tgatgatgga gactgagaac cgcctccact tcacgatcaa agatccagct    480

aacaggcgct acgaggtgcc cttggagacc ccgcatgtcc acagccgggc accgtcccca    540

ctctacagcg tggagttctc cgaggagccc ttcggggtga tcgtgcgccg gcagctggac    600

ggccgcgtgc tgctgaacac gacggtggcg cccctgttct ttgcggacca gttccttcag    660

ctgtccacct cgctgccctc gcagtatatc acaggcctcg ccgagcacct cagtcccctg    720

atgctcagca ccagctggac caggatcacc ctgtggaacc gggaccttgc gcccacgccc    780

ggtgcgaacc tctacgggtc tcaccctttc tacctggcgc tggaggacgg cgggtcggca    840

cacggggtgt tcctgctaaa cagcaatgcc atggatgtgg tcctgcagcc gagccctgcc    900

cttagctgga ggtcgacagg tgggatcctg gatgtctaca tcttcctggg cccagagccc    960

aagagcgtgg tgcagcagta cctggacgtt gtgggatacc cgttcatgcc gccatactgg   1020

ggcctgggct tccacctgtg ccgctggggc tactcctcca ccgctatcac ccgccaggtg   1080

gtggagaaca tgaccagggc ccacttcccc ctggacgtcc agtggaacga cctggactac   1140

atggactccc ggagggactt cacgttcaac aaggatggct tccgggactt cccggccatg   1200

gtgcaggagc tgcaccaggg cggccggcgc tacatgatga tcgtggatcc tgccatcagc   1260

agctcgggcc ctgccgggag ctacaggccc tacgacgagg gtctgcggag gggggttttc   1320

atcaccaacg agaccggcca gccgctgatt gggaaggtat ggcccgggtc cactgccttc   1380

cccgacttca ccaaccccac agccctggcc tggtgggagg acatggtggc tgagttccat   1440

gaccaggtgc ccttcgacgg catgtggatt gacatgaacg agccttccaa cttcatcagg   1500

ggctctgagg acggctgccc caacaatgag ctggagaacc caccctacgt gcctggggtg   1560

gttgggggga ccctccaggc ggccaccatc tgtgcctcca gccaccagtt tctctccaca   1620

cactacaacc tgcacaacct ctacggcctg accgaagcca tcgcctccca cagggcgctg   1680

gtgaaggctc gggggacacg cccatttgtg atctcccgct cgacctttgc tggccacggc   1740

cgatacgccg gccactggac gggggacgtg tggagctcct gggagcagct cgcctcctcc   1800

gtgccagaaa tcctgcagtt taacctgctg ggggtgcctc tggtcggggc cgacgtctgc   1860

ggcttcctgg gcaacacctc agaggagctg tgtgtgcgct ggacccagct gggggccttc   1920

taccccttca tgcggaacca caacagcctg ctcagtctgc cccaggagcc gtacagcttc   1980

agcgagccgg cccagcaggc catgaggaag gccctcaccc tgcgctacgc actcctcccc   2040

cacctctaca cactgttcca ccaggcccac gtcgcggggg agaccgtggc ccggcccctc   2100

ttcctggagt tccccaagga ctctagcacc tggactgtgg accaccagct cctgtggggg   2160

gaggccctgc tcatcacccc agtgctccag gccgggaagg ccgaagtgac tggctacttc   2220

cccttgggca catggtacga cctgcagacg gtgccagtag aggcccttgg cagcctccca   2280

cccccacctg cagctccccg tgagccagcc atccacagcg aggggcagtg ggtgacgctg   2340

ccggcccccc tggacaccat caacgtccac ctccgggctg ggtacatcat ccccctgcag   2400

ggccctggcc tcacaaccac agagtcccgc cagcagccca tggccctggc tgtggccctg   2460

accaagggtg gggaggcccg aggggagctg ttctgggacg atggagagag cctggaagtg   2520

ctggagcgag gggcctacac acaggtcatc ttcctggcca ggaataacac gatcgtgaat   2580

gagctggtac gtgtgaccag tgagggagct ggcctgcagc tgcagaaggt gactgtcctg   2640

ggcgtggcca cggcgcccca gcaggtcctc tccaacggtg tccctgtctc caacttcacc   2700

tacagccccg acaccaaggt cctggacatc tgtgtctcgc tgttgatggg agagcagttt   2760

ctcgtcagct ggtgttag                                                 2778


<210>  10
<211>  2778
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1 w/o sp

<400>  10
ggccatatcc tgctgcacga ctttctacta gtgcccagag agctgagcgg cagctctccc     60

gtgctggaag aaacacaccc tgcccatcag cagggcgcct ctagacctgg acctagagat    120

gcccaggccc accccggcag acctagagct gtgcctaccc agtgtgacgt gccccccaac    180

agcagattcg actgcgcccc tgacaaggcc atcacccagg aacagtgcga ggccagaggc    240

tgctgctaca tccctgccaa gcagggactg cagggcgctc agatgggaca gccctggtgc    300

ttcttcccac cctcctaccc cagctacaag ctggaaaacc tgagcagcag cgagatgggc    360

tacaccgcca ccctgaccag aaccaccccc acattcttcc caaaggacat cctgaccctg    420

cggctggacg tgatgatgga aaccgagaac cggctgcact tcaccatcaa ggaccccgcc    480

aatcggagat acgaggtgcc cctggaaacc ccccacgtgc actctagagc ccccagccct    540

ctgtacagcg tggaattcag cgaggaaccc ttcggcgtga tcgtgcggag acagctggat    600

ggcagagtgc tgctgaacac caccgtggcc cctctgttct tcgccgacca gttcctgcag    660

ctgagcacca gcctgcccag ccagtacatc acaggactgg ccgagcacct gagccccctg    720

atgctgagca catcctggac ccggatcacc ctgtggaaca gggatctggc ccctacccct    780

ggcgccaatc tgtacggcag ccaccctttc tacctggccc tggaagatgg cggatctgcc    840

cacggagtgt ttctgctgaa ctccaacgcc atggacgtgg tgctgcagcc tagccctgcc    900

ctgtcttgga gaagcacagg cggcatcctg gatgtgtaca tctttctggg ccccgagccc    960

aagagcgtgg tgcagcagta tctggatgtc gtgggctacc ccttcatgcc cccttactgg   1020

ggcctgggat tccacctgtg cagatggggc tactccagca ccgccatcac cagacaggtg   1080

gtggaaaaca tgaccagagc ccacttccca ctggatgtgc agtggaacga cctggactac   1140

atggacagca gacgggactt caccttcaac aaggacggct tccgggactt ccccgccatg   1200

gtgcaggaac tgcatcaggg cggcagacgg tacatgatga tcgtggatcc cgccatcagc   1260

tcctctggcc ctgccggctc ttacagaccc tacgacgagg gcctgcggag aggcgtgttc   1320

atcaccaacg agacaggcca gcccctgatc ggcaaagtgt ggcctggcag cacagccttc   1380

cccgacttca ccaatcctac cgccctggct tggtgggagg acatggtggc cgagttccac   1440

gaccaggtgc ccttcgacgg catgtggatc gacatgaacg agcccagcaa cttcatccgg   1500

ggcagcgagg atggctgccc caacaacgaa ctggaaaatc ccccttacgt gcccggcgtc   1560

gtgggcggaa cactgcaggc cgctacaatc tgtgccagca gccaccagtt tctgagcacc   1620

cactacaacc tgcacaacct gtacggcctg accgaggcca ttgccagcca ccgcgctctc   1680

gtgaaagcca gaggcacacg gcccttcgtg atcagcagaa gcacctttgc cggccacggc   1740

agatacgccg gacattggac tggcgacgtg tggtcctctt gggagcagct ggcctctagc   1800

gtgcccgaga tcctgcagtt caatctgctg ggcgtgccac tcgtgggcgc cgatgtgtgt   1860

ggcttcctgg gcaacacctc cgaggaactg tgtgtgcggt ggacacagct gggcgccttc   1920

taccctttca tgagaaacca caacagcctg ctgagcctgc cccaggaacc ctacagcttt   1980

agcgagcctg cacagcaggc catgcggaag gccctgacac tgagatacgc tctgctgccc   2040

cacctgtaca ccctgtttca ccaggcccat gtggccggcg agacagtggc cagacctctg   2100

tttctggaat tccccaagga cagcagcacc tggaccgtgg accatcagct gctgtgggga   2160

gaggctctgc tgattacccc agtgctgcag gcaggcaagg ccgaagtgac cggctacttt   2220

cccctgggca cttggtacga cctgcagacc gtgcctgtgg aagccctggg atctctgcct   2280

ccacctcctg ccgctcctag agagcctgcc attcactctg agggccagtg ggtcacactg   2340

cctgcccccc tggataccat caacgtgcac ctgagggccg gctacatcat accactgcag   2400

ggacctggcc tgaccaccac cgagtctaga cagcagccaa tggccctggc cgtggccctg   2460

accaaaggcg gagaagctag gggcgagctg ttctgggacg atggcgagag cctggaagtg   2520

ctggaaagag gcgcctatac ccaagtgatc ttcctggccc ggaacaacac catcgtgaac   2580

gagctggtgc gcgtgacctc tgaaggcgct ggactgcagc tgcagaaagt gaccgtgctg   2640

ggagtggcca cagcccctca gcaggtgctg tctaatggcg tgcccgtgtc caacttcacc   2700

tacagccccg acaccaaggt gctggacatc tgcgtgtcac tgctgatggg agagcagttt   2760

ctggtgtcct ggtgctga                                                 2778


<210>  11
<211>  2778
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2 w/o sp

<400>  11
ggacacatcc tgctgcacga cttcctgttg gtgcctagag agctgagcgg atcatcccca     60

gtgctggagg agactcatcc tgctcaccaa cagggagctt ccagaccagg accgagagac    120

gcccaagccc atcctggtag accaagagct gtgcctaccc aatgcgacgt gccacccaac    180

tcccgattcg actgcgcgcc agataaggct attacccaag agcagtgtga agccagaggt    240

tgctgctaca tcccagcgaa gcaaggattg caaggcgccc aaatgggaca accttggtgt    300

ttcttccccc cttcgtaccc atcatataaa ctcgaaaacc tgtcctcttc ggaaatgggt    360

tatactgcca ccctcaccag aactactcct actttcttcc cgaaagacat cttgaccttg    420

aggctggacg tgatgatgga gactgaaaac cggctgcatt tcactatcaa agatcctgcc    480

aatcggcgat acgaggtccc tctggaaacc cctcacgtgc actcacgggc tccttctccg    540

ctttactccg tcgaattctc tgaggaaccc ttcggagtga tcgttagacg ccagctggat    600

ggtagagtgc tgttgaacac tactgtggcc ccacttttct tcgctgacca gtttctgcaa    660

ctgtccactt ccctgccatc ccagtacatt actggactcg ccgaacacct gtcgccactg    720

atgctctcga cctcttggac tagaatcact ttgtggaaca gagacttggc ccctactccg    780

ggagcaaatc tgtacggaag ccaccctttt tacctggcgc tcgaagatgg cggatccgct    840

cacggagtgt tcctgctgaa tagcaacgca atggacgtgg tgctgcaacc ttcccctgca    900

ctcagttgga gaagtaccgg gggtattctg gacgtgtaca tcttcctcgg accagaaccc    960

aagagcgtgg tgcagcaata tctggacgtg gtcggatacc cttttatgcc tccttactgg   1020

ggactgggat tccacctttg ccgttggggc tactcatcca ccgccattac cagacaggtg   1080

gtggagaata tgaccagagc ccacttccct ctcgacgtgc agtggaacga tctggactat   1140

atggactccc ggagagattt caccttcaac aaggacgggt tccgcgattt tcccgcgatg   1200

gttcaagagc tccaccaggg tggtcgaaga tatatgatga tcgtcgaccc agccatttcg   1260

agcagcggac ccgctggatc ttatagacct tacgacgaag gccttaggag aggagtgttc   1320

atcacaaacg agactggaca gcctttgatc ggtaaagtgt ggcctggatc aaccgccttt   1380

cctgacttta ccaatcccac tgccttggct tggtgggagg acatggtggc cgaattccac   1440

gaccaagtcc cctttgatgg aatgtggatc gatatgaacg aaccaagcaa ttttatcaga   1500

ggttccgaag acggttgccc caacaacgaa ctggaaaacc ctccttatgt gcccggagtc   1560

gtgggcggaa cattacaggc cgcgactatt tgcgccagca gccaccaatt cctgtccact   1620

cactacaacc tccacaacct ttatggatta accgaagcta ttgcaagtca cagggctctg   1680

gtgaaggcta gagggactag gccctttgtg atctcccgat ccacctttgc cggacacggg   1740

agatacgccg gtcactggac tggtgacgtg tggagctcat gggaacaact ggcctcctcc   1800

gtgccggaaa tcttacagtt caaccttctg ggtgtccctc ttgtcggagc agacgtgtgt   1860

gggtttcttg gtaacacctc cgaggaactg tgtgtgcgct ggactcaact gggtgcattc   1920

tacccattca tgagaaacca caactccttg ctgtccctgc cacaagagcc ctactcgttc   1980

agcgagcctg cacaacaggc tatgcggaag gcactgaccc tgagatacgc cctgcttcca   2040

cacttataca ctctcttcca tcaagcgcat gtggcaggag aaaccgttgc aaggcctctt   2100

ttccttgaat tccccaagga ttcctcgact tggacggtgg atcatcagct gctgtgggga   2160

gaagctctgc tgattactcc agtgttgcaa gccggaaaag ctgaggtgac cggatacttt   2220

ccgctgggaa cctggtacga cctccagact gtccctgttg aagcccttgg atcactgcct   2280

ccgcctccgg cagctccacg cgaaccagct atacattccg agggacagtg ggttacatta   2340

ccagctcctc tggacacaat caacgtccac ttaagagctg gctacattat ccctctgcaa   2400

ggaccaggac tgactacgac cgagagcaga cagcagccaa tggcactggc tgtggctctg   2460

accaagggag gggaagctag aggagaactc ttctgggatg atggggagtc ccttgaagtg   2520

ctggaaagag gcgcttacac tcaagtcatt ttccttgcac ggaacaacac cattgtgaac   2580

gaattggtgc gagtgaccag cgaaggagct ggacttcaac tgcagaaggt cactgtgctc   2640

ggagtggcta ccgctcctca gcaagtgctg tcgaatggag tccccgtgtc aaactttacc   2700

tactcccctg acactaaggt gctcgacatt tgcgtgtccc tcctgatggg agagcagttc   2760

cttgtgtcct ggtgttga                                                 2778


<210>  12
<211>  2754
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1-delta-8 w/o sp

<400>  12
ctactagtgc ccagagagct gagcggcagc tctcccgtgc tggaagaaac acaccctgcc     60

catcagcagg gcgcctctag acctggacct agagatgccc aggcccaccc cggcagacct    120

agagctgtgc ctacccagtg tgacgtgccc cccaacagca gattcgactg cgcccctgac    180

aaggccatca cccaggaaca gtgcgaggcc agaggctgct gctacatccc tgccaagcag    240

ggactgcagg gcgctcagat gggacagccc tggtgcttct tcccaccctc ctaccccagc    300

tacaagctgg aaaacctgag cagcagcgag atgggctaca ccgccaccct gaccagaacc    360

acccccacat tcttcccaaa ggacatcctg accctgcggc tggacgtgat gatggaaacc    420

gagaaccggc tgcacttcac catcaaggac cccgccaatc ggagatacga ggtgcccctg    480

gaaacccccc acgtgcactc tagagccccc agccctctgt acagcgtgga attcagcgag    540

gaacccttcg gcgtgatcgt gcggagacag ctggatggca gagtgctgct gaacaccacc    600

gtggcccctc tgttcttcgc cgaccagttc ctgcagctga gcaccagcct gcccagccag    660

tacatcacag gactggccga gcacctgagc cccctgatgc tgagcacatc ctggacccgg    720

atcaccctgt ggaacaggga tctggcccct acccctggcg ccaatctgta cggcagccac    780

cctttctacc tggccctgga agatggcgga tctgcccacg gagtgtttct gctgaactcc    840

aacgccatgg acgtggtgct gcagcctagc cctgccctgt cttggagaag cacaggcggc    900

atcctggatg tgtacatctt tctgggcccc gagcccaaga gcgtggtgca gcagtatctg    960

gatgtcgtgg gctacccctt catgccccct tactggggcc tgggattcca cctgtgcaga   1020

tggggctact ccagcaccgc catcaccaga caggtggtgg aaaacatgac cagagcccac   1080

ttcccactgg atgtgcagtg gaacgacctg gactacatgg acagcagacg ggacttcacc   1140

ttcaacaagg acggcttccg ggacttcccc gccatggtgc aggaactgca tcagggcggc   1200

agacggtaca tgatgatcgt ggatcccgcc atcagctcct ctggccctgc cggctcttac   1260

agaccctacg acgagggcct gcggagaggc gtgttcatca ccaacgagac aggccagccc   1320

ctgatcggca aagtgtggcc tggcagcaca gccttccccg acttcaccaa tcctaccgcc   1380

ctggcttggt gggaggacat ggtggccgag ttccacgacc aggtgccctt cgacggcatg   1440

tggatcgaca tgaacgagcc cagcaacttc atccggggca gcgaggatgg ctgccccaac   1500

aacgaactgg aaaatccccc ttacgtgccc ggcgtcgtgg gcggaacact gcaggccgct   1560

acaatctgtg ccagcagcca ccagtttctg agcacccact acaacctgca caacctgtac   1620

ggcctgaccg aggccattgc cagccaccgc gctctcgtga aagccagagg cacacggccc   1680

ttcgtgatca gcagaagcac ctttgccggc cacggcagat acgccggaca ttggactggc   1740

gacgtgtggt cctcttggga gcagctggcc tctagcgtgc ccgagatcct gcagttcaat   1800

ctgctgggcg tgccactcgt gggcgccgat gtgtgtggct tcctgggcaa cacctccgag   1860

gaactgtgtg tgcggtggac acagctgggc gccttctacc ctttcatgag aaaccacaac   1920

agcctgctga gcctgcccca ggaaccctac agctttagcg agcctgcaca gcaggccatg   1980

cggaaggccc tgacactgag atacgctctg ctgccccacc tgtacaccct gtttcaccag   2040

gcccatgtgg ccggcgagac agtggccaga cctctgtttc tggaattccc caaggacagc   2100

agcacctgga ccgtggacca tcagctgctg tggggagagg ctctgctgat taccccagtg   2160

ctgcaggcag gcaaggccga agtgaccggc tactttcccc tgggcacttg gtacgacctg   2220

cagaccgtgc ctgtggaagc cctgggatct ctgcctccac ctcctgccgc tcctagagag   2280

cctgccattc actctgaggg ccagtgggtc acactgcctg cccccctgga taccatcaac   2340

gtgcacctga gggccggcta catcatacca ctgcagggac ctggcctgac caccaccgag   2400

tctagacagc agccaatggc cctggccgtg gccctgacca aaggcggaga agctaggggc   2460

gagctgttct gggacgatgg cgagagcctg gaagtgctgg aaagaggcgc ctatacccaa   2520

gtgatcttcc tggcccggaa caacaccatc gtgaacgagc tggtgcgcgt gacctctgaa   2580

ggcgctggac tgcagctgca gaaagtgacc gtgctgggag tggccacagc ccctcagcag   2640

gtgctgtcta atggcgtgcc cgtgtccaac ttcacctaca gccccgacac caaggtgctg   2700

gacatctgcg tgtcactgct gatgggagag cagtttctgg tgtcctggtg ctga         2754


<210>  13
<211>  2754
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2-delta8 w/o sp

<400>  13
ctgttggtgc ctagagagct gagcggatca tccccagtgc tggaggagac tcatcctgct     60

caccaacagg gagcttccag accaggaccg agagacgccc aagcccatcc tggtagacca    120

agagctgtgc ctacccaatg cgacgtgcca cccaactccc gattcgactg cgcgccagat    180

aaggctatta cccaagagca gtgtgaagcc agaggttgct gctacatccc agcgaagcaa    240

ggattgcaag gcgcccaaat gggacaacct tggtgtttct tccccccttc gtacccatca    300

tataaactcg aaaacctgtc ctcttcggaa atgggttata ctgccaccct caccagaact    360

actcctactt tcttcccgaa agacatcttg accttgaggc tggacgtgat gatggagact    420

gaaaaccggc tgcatttcac tatcaaagat cctgccaatc ggcgatacga ggtccctctg    480

gaaacccctc acgtgcactc acgggctcct tctccgcttt actccgtcga attctctgag    540

gaacccttcg gagtgatcgt tagacgccag ctggatggta gagtgctgtt gaacactact    600

gtggccccac ttttcttcgc tgaccagttt ctgcaactgt ccacttccct gccatcccag    660

tacattactg gactcgccga acacctgtcg ccactgatgc tctcgacctc ttggactaga    720

atcactttgt ggaacagaga cttggcccct actccgggag caaatctgta cggaagccac    780

cctttttacc tggcgctcga agatggcgga tccgctcacg gagtgttcct gctgaatagc    840

aacgcaatgg acgtggtgct gcaaccttcc cctgcactca gttggagaag taccgggggt    900

attctggacg tgtacatctt cctcggacca gaacccaaga gcgtggtgca gcaatatctg    960

gacgtggtcg gatacccttt tatgcctcct tactggggac tgggattcca cctttgccgt   1020

tggggctact catccaccgc cattaccaga caggtggtgg agaatatgac cagagcccac   1080

ttccctctcg acgtgcagtg gaacgatctg gactatatgg actcccggag agatttcacc   1140

ttcaacaagg acgggttccg cgattttccc gcgatggttc aagagctcca ccagggtggt   1200

cgaagatata tgatgatcgt cgacccagcc atttcgagca gcggacccgc tggatcttat   1260

agaccttacg acgaaggcct taggagagga gtgttcatca caaacgagac tggacagcct   1320

ttgatcggta aagtgtggcc tggatcaacc gcctttcctg actttaccaa tcccactgcc   1380

ttggcttggt gggaggacat ggtggccgaa ttccacgacc aagtcccctt tgatggaatg   1440

tggatcgata tgaacgaacc aagcaatttt atcagaggtt ccgaagacgg ttgccccaac   1500

aacgaactgg aaaaccctcc ttatgtgccc ggagtcgtgg gcggaacatt acaggccgcg   1560

actatttgcg ccagcagcca ccaattcctg tccactcact acaacctcca caacctttat   1620

ggattaaccg aagctattgc aagtcacagg gctctggtga aggctagagg gactaggccc   1680

tttgtgatct cccgatccac ctttgccgga cacgggagat acgccggtca ctggactggt   1740

gacgtgtgga gctcatggga acaactggcc tcctccgtgc cggaaatctt acagttcaac   1800

cttctgggtg tccctcttgt cggagcagac gtgtgtgggt ttcttggtaa cacctccgag   1860

gaactgtgtg tgcgctggac tcaactgggt gcattctacc cattcatgag aaaccacaac   1920

tccttgctgt ccctgccaca agagccctac tcgttcagcg agcctgcaca acaggctatg   1980

cggaaggcac tgaccctgag atacgccctg cttccacact tatacactct cttccatcaa   2040

gcgcatgtgg caggagaaac cgttgcaagg cctcttttcc ttgaattccc caaggattcc   2100

tcgacttgga cggtggatca tcagctgctg tggggagaag ctctgctgat tactccagtg   2160

ttgcaagccg gaaaagctga ggtgaccgga tactttccgc tgggaacctg gtacgacctc   2220

cagactgtcc ctgttgaagc ccttggatca ctgcctccgc ctccggcagc tccacgcgaa   2280

ccagctatac attccgaggg acagtgggtt acattaccag ctcctctgga cacaatcaac   2340

gtccacttaa gagctggcta cattatccct ctgcaaggac caggactgac tacgaccgag   2400

agcagacagc agccaatggc actggctgtg gctctgacca agggagggga agctagagga   2460

gaactcttct gggatgatgg ggagtccctt gaagtgctgg aaagaggcgc ttacactcaa   2520

gtcattttcc ttgcacggaa caacaccatt gtgaacgaat tggtgcgagt gaccagcgaa   2580

ggagctggac ttcaactgca gaaggtcact gtgctcggag tggctaccgc tcctcagcaa   2640

gtgctgtcga atggagtccc cgtgtcaaac tttacctact cccctgacac taaggtgctc   2700

gacatttgcg tgtccctcct gatgggagag cagttccttg tgtcctggtg ttga         2754


<210>  14
<211>  397
<212>  DNA
<213>  artificial

<220>
<223>  hAAT promoter

<400>  14
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac    120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca    180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact    240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct    300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct    360

cagcttcagg caccaccact gacctgggac agtgaat                             397


<210>  15
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  ApoE control region

<400>  15
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg g                                              321


<210>  16
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  HBB2 intron

<400>  16
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt     60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca    120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata    180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt    240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt    300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa    360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc    420

tggcccatca ctttggcaaa g                                              441


<210>  17
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  modified HBB2 intron

<400>  17
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt     60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca    120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata    180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt    240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt    300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa    360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc    420

tggcccatca ctttggcaaa g                                              441


<210>  18
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  FIX intron

<400>  18
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct     60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta    120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc    180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt    240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa    300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta    360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc    420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt    480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa    540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta    600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa    660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga    720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt    780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac    840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt    900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc    960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt   1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc   1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg   1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt   1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt   1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct   1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta   1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca     1438


<210>  19
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  modified FIX intron

<400>  19
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct     60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta    120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc    180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt    240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa    300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta    360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc    420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt    480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa    540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta    600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa    660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga    720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt    780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac    840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt    900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc    960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt   1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc   1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg   1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt   1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt   1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct   1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta   1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca     1438


<210>  20
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  chicken beta-globin intron

<400>  20
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc     60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc    120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga    180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg    240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg    300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg    360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt    420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca    480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg    540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc    600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg    660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc    720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac    780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga    840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                        881


<210>  21
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  modified chicken beta-globin intron

<400>  21
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc     60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc    120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga    180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg    240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg    300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg    360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt    420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca    480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg    540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc    600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg    660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc    720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac    780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga    840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                        881


<210>  22
<211>  4318
<212>  DNA
<213>  artificial

<220>
<223>  construct: sp2+hGAAwt-delta-8

<400>  22
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatgccg tcttctgtct cgtggggcat cctcctgctg   1320

gcaggcctgt gctgcctggt ccctgtctcc ctggctctgc tggttccccg agagctgagt   1380

ggctcctccc cagtcctgga ggagactcac ccagctcacc agcagggagc cagcagacca   1440

gggccccggg atgcccaggc acaccccggg cggccgcgag cagtgcccac acagtgcgac   1500

gtccccccca acagccgctt cgattgcgcc cctgacaagg ccatcaccca ggaacagtgc   1560

gaggcccgcg gctgttgcta catccctgca aagcaggggc tgcagggagc ccagatgggg   1620

cagccctggt gcttcttccc acccagctac cccagctaca agctggagaa cctgagctcc   1680

tctgaaatgg gctacacggc caccctgacc cgtaccaccc ccaccttctt ccccaaggac   1740

atcctgaccc tgcggctgga cgtgatgatg gagactgaga accgcctcca cttcacgatc   1800

aaagatccag ctaacaggcg ctacgaggtg cccttggaga ccccgcatgt ccacagccgg   1860

gcaccgtccc cactctacag cgtggagttc tccgaggagc ccttcggggt gatcgtgcgc   1920

cggcagctgg acggccgcgt gctgctgaac acgacggtgg cgcccctgtt ctttgcggac   1980

cagttccttc agctgtccac ctcgctgccc tcgcagtata tcacaggcct cgccgagcac   2040

ctcagtcccc tgatgctcag caccagctgg accaggatca ccctgtggaa ccgggacctt   2100

gcgcccacgc ccggtgcgaa cctctacggg tctcaccctt tctacctggc gctggaggac   2160

ggcgggtcgg cacacggggt gttcctgcta aacagcaatg ccatggatgt ggtcctgcag   2220

ccgagccctg cccttagctg gaggtcgaca ggtgggatcc tggatgtcta catcttcctg   2280

ggcccagagc ccaagagcgt ggtgcagcag tacctggacg ttgtgggata cccgttcatg   2340

ccgccatact ggggcctggg cttccacctg tgccgctggg gctactcctc caccgctatc   2400

acccgccagg tggtggagaa catgaccagg gcccacttcc ccctggacgt ccagtggaac   2460

gacctggact acatggactc ccggagggac ttcacgttca acaaggatgg cttccgggac   2520

ttcccggcca tggtgcagga gctgcaccag ggcggccggc gctacatgat gatcgtggat   2580

cctgccatca gcagctcggg ccctgccggg agctacaggc cctacgacga gggtctgcgg   2640

aggggggttt tcatcaccaa cgagaccggc cagccgctga ttgggaaggt atggcccggg   2700

tccactgcct tccccgactt caccaacccc acagccctgg cctggtggga ggacatggtg   2760

gctgagttcc atgaccaggt gcccttcgac ggcatgtgga ttgacatgaa cgagccttcc   2820

aacttcatca ggggctctga ggacggctgc cccaacaatg agctggagaa cccaccctac   2880

gtgcctgggg tggttggggg gaccctccag gcggccacca tctgtgcctc cagccaccag   2940

tttctctcca cacactacaa cctgcacaac ctctacggcc tgaccgaagc catcgcctcc   3000

cacagggcgc tggtgaaggc tcgggggaca cgcccatttg tgatctcccg ctcgaccttt   3060

gctggccacg gccgatacgc cggccactgg acgggggacg tgtggagctc ctgggagcag   3120

ctcgcctcct ccgtgccaga aatcctgcag tttaacctgc tgggggtgcc tctggtcggg   3180

gccgacgtct gcggcttcct gggcaacacc tcagaggagc tgtgtgtgcg ctggacccag   3240

ctgggggcct tctacccctt catgcggaac cacaacagcc tgctcagtct gccccaggag   3300

ccgtacagct tcagcgagcc ggcccagcag gccatgagga aggccctcac cctgcgctac   3360

gcactcctcc cccacctcta cacactgttc caccaggccc acgtcgcggg ggagaccgtg   3420

gcccggcccc tcttcctgga gttccccaag gactctagca cctggactgt ggaccaccag   3480

ctcctgtggg gggaggccct gctcatcacc ccagtgctcc aggccgggaa ggccgaagtg   3540

actggctact tccccttggg cacatggtac gacctgcaga cggtgccagt agaggccctt   3600

ggcagcctcc cacccccacc tgcagctccc cgtgagccag ccatccacag cgaggggcag   3660

tgggtgacgc tgccggcccc cctggacacc atcaacgtcc acctccgggc tgggtacatc   3720

atccccctgc agggccctgg cctcacaacc acagagtccc gccagcagcc catggccctg   3780

gctgtggccc tgaccaaggg tggggaggcc cgaggggagc tgttctggga cgatggagag   3840

agcctggaag tgctggagcg aggggcctac acacaggtca tcttcctggc caggaataac   3900

acgatcgtga atgagctggt acgtgtgacc agtgagggag ctggcctgca gctgcagaag   3960

gtgactgtcc tgggcgtggc cacggcgccc cagcaggtcc tctccaacgg tgtccctgtc   4020

tccaacttca cctacagccc cgacaccaag gtcctggaca tctgtgtctc gctgttgatg   4080

ggagagcagt ttctcgtcag ctggtgttag ctcgagagat ctaccggtga attcaccgcg   4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc   4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc   4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga     4318


<210>  23
<211>  4318
<212>  DNA
<213>  artificial

<220>
<223>  construct: sp2+hGAAco1-delta-8

<400>  23
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatgcct agctctgtgt cctggggcat tctgctgctg   1320

gccggcctgt gttgtctggt gcctgtgtct ctggccctac tagtgcccag agagctgagc   1380

ggcagctctc ccgtgctgga agaaacacac cctgcccatc agcagggcgc ctctagacct   1440

ggacctagag atgcccaggc ccaccccggc agacctagag ctgtgcctac ccagtgtgac   1500

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc   1560

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga   1620

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc   1680

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac   1740

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc   1800

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga   1860

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg   1920

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac   1980

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac   2040

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg   2100

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat   2160

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag   2220

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg   2280

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg   2340

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc   2400

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac   2460

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac   2520

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat   2580

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg   2640

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc   2700

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg   2760

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc   2820

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac   2880

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag   2940

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc   3000

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt   3060

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag   3120

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc   3180

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag   3240

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa   3300

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac   3360

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg   3420

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag   3480

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg   3540

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg   3600

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag   3660

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc   3720

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg   3780

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag   3840

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac   3900

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa   3960

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg   4020

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg   4080

ggagagcagt ttctggtgtc ctggtgctga ctcgagagat ctaccggtga attcaccgcg   4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc   4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc   4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga     4318


<210>  24
<211>  4318
<212>  DNA
<213>  artificial

<220>
<223>  construct: sp2+hGAAco2-delta-8

<400>  24
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatgcca tcgtcagtgt cttggggcat tcttctgctc   1320

gccggattgt gttgcctggt gcctgtctca ttggccctgt tggtgcctag agagctgagc   1380

ggatcatccc cagtgctgga ggagactcat cctgctcacc aacagggagc ttccagacca   1440

ggaccgagag acgcccaagc ccatcctggt agaccaagag ctgtgcctac ccaatgcgac   1500

gtgccaccca actcccgatt cgactgcgcg ccagataagg ctattaccca agagcagtgt   1560

gaagccagag gttgctgcta catcccagcg aagcaaggat tgcaaggcgc ccaaatggga   1620

caaccttggt gtttcttccc cccttcgtac ccatcatata aactcgaaaa cctgtcctct   1680

tcggaaatgg gttatactgc caccctcacc agaactactc ctactttctt cccgaaagac   1740

atcttgacct tgaggctgga cgtgatgatg gagactgaaa accggctgca tttcactatc   1800

aaagatcctg ccaatcggcg atacgaggtc cctctggaaa cccctcacgt gcactcacgg   1860

gctccttctc cgctttactc cgtcgaattc tctgaggaac ccttcggagt gatcgttaga   1920

cgccagctgg atggtagagt gctgttgaac actactgtgg ccccactttt cttcgctgac   1980

cagtttctgc aactgtccac ttccctgcca tcccagtaca ttactggact cgccgaacac   2040

ctgtcgccac tgatgctctc gacctcttgg actagaatca ctttgtggaa cagagacttg   2100

gcccctactc cgggagcaaa tctgtacgga agccaccctt tttacctggc gctcgaagat   2160

ggcggatccg ctcacggagt gttcctgctg aatagcaacg caatggacgt ggtgctgcaa   2220

ccttcccctg cactcagttg gagaagtacc gggggtattc tggacgtgta catcttcctc   2280

ggaccagaac ccaagagcgt ggtgcagcaa tatctggacg tggtcggata cccttttatg   2340

cctccttact ggggactggg attccacctt tgccgttggg gctactcatc caccgccatt   2400

accagacagg tggtggagaa tatgaccaga gcccacttcc ctctcgacgt gcagtggaac   2460

gatctggact atatggactc ccggagagat ttcaccttca acaaggacgg gttccgcgat   2520

tttcccgcga tggttcaaga gctccaccag ggtggtcgaa gatatatgat gatcgtcgac   2580

ccagccattt cgagcagcgg acccgctgga tcttatagac cttacgacga aggccttagg   2640

agaggagtgt tcatcacaaa cgagactgga cagcctttga tcggtaaagt gtggcctgga   2700

tcaaccgcct ttcctgactt taccaatccc actgccttgg cttggtggga ggacatggtg   2760

gccgaattcc acgaccaagt cccctttgat ggaatgtgga tcgatatgaa cgaaccaagc   2820

aattttatca gaggttccga agacggttgc cccaacaacg aactggaaaa ccctccttat   2880

gtgcccggag tcgtgggcgg aacattacag gccgcgacta tttgcgccag cagccaccaa   2940

ttcctgtcca ctcactacaa cctccacaac ctttatggat taaccgaagc tattgcaagt   3000

cacagggctc tggtgaaggc tagagggact aggccctttg tgatctcccg atccaccttt   3060

gccggacacg ggagatacgc cggtcactgg actggtgacg tgtggagctc atgggaacaa   3120

ctggcctcct ccgtgccgga aatcttacag ttcaaccttc tgggtgtccc tcttgtcgga   3180

gcagacgtgt gtgggtttct tggtaacacc tccgaggaac tgtgtgtgcg ctggactcaa   3240

ctgggtgcat tctacccatt catgagaaac cacaactcct tgctgtccct gccacaagag   3300

ccctactcgt tcagcgagcc tgcacaacag gctatgcgga aggcactgac cctgagatac   3360

gccctgcttc cacacttata cactctcttc catcaagcgc atgtggcagg agaaaccgtt   3420

gcaaggcctc ttttccttga attccccaag gattcctcga cttggacggt ggatcatcag   3480

ctgctgtggg gagaagctct gctgattact ccagtgttgc aagccggaaa agctgaggtg   3540

accggatact ttccgctggg aacctggtac gacctccaga ctgtccctgt tgaagccctt   3600

ggatcactgc ctccgcctcc ggcagctcca cgcgaaccag ctatacattc cgagggacag   3660

tgggttacat taccagctcc tctggacaca atcaacgtcc acttaagagc tggctacatt   3720

atccctctgc aaggaccagg actgactacg accgagagca gacagcagcc aatggcactg   3780

gctgtggctc tgaccaaggg aggggaagct agaggagaac tcttctggga tgatggggag   3840

tcccttgaag tgctggaaag aggcgcttac actcaagtca ttttccttgc acggaacaac   3900

accattgtga acgaattggt gcgagtgacc agcgaaggag ctggacttca actgcagaag   3960

gtcactgtgc tcggagtggc taccgctcct cagcaagtgc tgtcgaatgg agtccccgtg   4020

tcaaacttta cctactcccc tgacactaag gtgctcgaca tttgcgtgtc cctcctgatg   4080

ggagagcagt tccttgtgtc ctggtgttga ctcgagagat ctaccggtga attcaccgcg   4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc   4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc   4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga     4318


<210>  25
<211>  4300
<212>  DNA
<213>  artificial

<220>
<223>  construct: sp7+hGAAco1-delta-8

<400>  25
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg   1320

ctgggcacca ccttcggcct actagtgccc agagagctga gcggcagctc tcccgtgctg   1380

gaagaaacac accctgccca tcagcagggc gcctctagac ctggacctag agatgcccag   1440

gcccaccccg gcagacctag agctgtgcct acccagtgtg acgtgccccc caacagcaga   1500

ttcgactgcg cccctgacaa ggccatcacc caggaacagt gcgaggccag aggctgctgc   1560

tacatccctg ccaagcaggg actgcagggc gctcagatgg gacagccctg gtgcttcttc   1620

ccaccctcct accccagcta caagctggaa aacctgagca gcagcgagat gggctacacc   1680

gccaccctga ccagaaccac ccccacattc ttcccaaagg acatcctgac cctgcggctg   1740

gacgtgatga tggaaaccga gaaccggctg cacttcacca tcaaggaccc cgccaatcgg   1800

agatacgagg tgcccctgga aaccccccac gtgcactcta gagcccccag ccctctgtac   1860

agcgtggaat tcagcgagga acccttcggc gtgatcgtgc ggagacagct ggatggcaga   1920

gtgctgctga acaccaccgt ggcccctctg ttcttcgccg accagttcct gcagctgagc   1980

accagcctgc ccagccagta catcacagga ctggccgagc acctgagccc cctgatgctg   2040

agcacatcct ggacccggat caccctgtgg aacagggatc tggcccctac ccctggcgcc   2100

aatctgtacg gcagccaccc tttctacctg gccctggaag atggcggatc tgcccacgga   2160

gtgtttctgc tgaactccaa cgccatggac gtggtgctgc agcctagccc tgccctgtct   2220

tggagaagca caggcggcat cctggatgtg tacatctttc tgggccccga gcccaagagc   2280

gtggtgcagc agtatctgga tgtcgtgggc taccccttca tgccccctta ctggggcctg   2340

ggattccacc tgtgcagatg gggctactcc agcaccgcca tcaccagaca ggtggtggaa   2400

aacatgacca gagcccactt cccactggat gtgcagtgga acgacctgga ctacatggac   2460

agcagacggg acttcacctt caacaaggac ggcttccggg acttccccgc catggtgcag   2520

gaactgcatc agggcggcag acggtacatg atgatcgtgg atcccgccat cagctcctct   2580

ggccctgccg gctcttacag accctacgac gagggcctgc ggagaggcgt gttcatcacc   2640

aacgagacag gccagcccct gatcggcaaa gtgtggcctg gcagcacagc cttccccgac   2700

ttcaccaatc ctaccgccct ggcttggtgg gaggacatgg tggccgagtt ccacgaccag   2760

gtgcccttcg acggcatgtg gatcgacatg aacgagccca gcaacttcat ccggggcagc   2820

gaggatggct gccccaacaa cgaactggaa aatccccctt acgtgcccgg cgtcgtgggc   2880

ggaacactgc aggccgctac aatctgtgcc agcagccacc agtttctgag cacccactac   2940

aacctgcaca acctgtacgg cctgaccgag gccattgcca gccaccgcgc tctcgtgaaa   3000

gccagaggca cacggccctt cgtgatcagc agaagcacct ttgccggcca cggcagatac   3060

gccggacatt ggactggcga cgtgtggtcc tcttgggagc agctggcctc tagcgtgccc   3120

gagatcctgc agttcaatct gctgggcgtg ccactcgtgg gcgccgatgt gtgtggcttc   3180

ctgggcaaca cctccgagga actgtgtgtg cggtggacac agctgggcgc cttctaccct   3240

ttcatgagaa accacaacag cctgctgagc ctgccccagg aaccctacag ctttagcgag   3300

cctgcacagc aggccatgcg gaaggccctg acactgagat acgctctgct gccccacctg   3360

tacaccctgt ttcaccaggc ccatgtggcc ggcgagacag tggccagacc tctgtttctg   3420

gaattcccca aggacagcag cacctggacc gtggaccatc agctgctgtg gggagaggct   3480

ctgctgatta ccccagtgct gcaggcaggc aaggccgaag tgaccggcta ctttcccctg   3540

ggcacttggt acgacctgca gaccgtgcct gtggaagccc tgggatctct gcctccacct   3600

cctgccgctc ctagagagcc tgccattcac tctgagggcc agtgggtcac actgcctgcc   3660

cccctggata ccatcaacgt gcacctgagg gccggctaca tcataccact gcagggacct   3720

ggcctgacca ccaccgagtc tagacagcag ccaatggccc tggccgtggc cctgaccaaa   3780

ggcggagaag ctaggggcga gctgttctgg gacgatggcg agagcctgga agtgctggaa   3840

agaggcgcct atacccaagt gatcttcctg gcccggaaca acaccatcgt gaacgagctg   3900

gtgcgcgtga cctctgaagg cgctggactg cagctgcaga aagtgaccgt gctgggagtg   3960

gccacagccc ctcagcaggt gctgtctaat ggcgtgcccg tgtccaactt cacctacagc   4020

cccgacacca aggtgctgga catctgcgtg tcactgctga tgggagagca gtttctggtg   4080

tcctggtgct gactcgagag atctaccggt gaattcaccg cgggtttaaa ctgtgccttc   4140

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc   4200

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg   4260

tcattctatt ctggggggtg gggtgggggc tagctctaga                         4300


<210>  26
<211>  4198
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco1-delta-42

<400>  26
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg   1320

ctgggcacca ccttcggcgc ccaccccggc agacctagag ctgtgcctac ccagtgtgac   1380

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc   1440

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga   1500

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc   1560

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac   1620

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc   1680

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga   1740

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg   1800

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac   1860

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac   1920

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg   1980

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat   2040

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag   2100

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg   2160

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg   2220

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc   2280

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac   2340

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac   2400

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat   2460

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg   2520

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc   2580

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg   2640

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc   2700

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac   2760

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag   2820

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc   2880

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt   2940

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag   3000

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc   3060

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag   3120

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa   3180

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac   3240

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg   3300

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag   3360

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg   3420

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg   3480

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag   3540

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc   3600

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg   3660

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag   3720

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac   3780

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa   3840

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg   3900

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg   3960

ggagagcagt ttctggtgtc ctggtgctga ctcgagagat ctaccggtga attcaccgcg   4020

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc   4080

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc   4140

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga     4198


<210>  27
<211>  917
<212>  PRT
<213>  artificial

<220>
<223>  hGAA-delta-8

<400>  27

Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val Leu Glu Glu 
1               5                   10                  15      


Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp 
            20                  25                  30          


Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp 
        35                  40                  45              


Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr 
    50                  55                  60                  


Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln 
65                  70                  75                  80  


Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro 
                85                  90                  95      


Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly 
            100                 105                 110         


Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp 
        115                 120                 125             


Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu 
    130                 135                 140                 


His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu 
145                 150                 155                 160 


Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val 
                165                 170                 175     


Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp 
            180                 185                 190         


Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp 
        195                 200                 205             


Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly 
    210                 215                 220                 


Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg 
225                 230                 235                 240 


Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu 
                245                 250                 255     


Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala 
            260                 265                 270         


His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln 
        275                 280                 285             


Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val 
    290                 295                 300                 


Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu 
305                 310                 315                 320 


Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe 
                325                 330                 335     


His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val 
            340                 345                 350         


Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn 
        355                 360                 365             


Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp 
    370                 375                 380                 


Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly 
385                 390                 395                 400 


Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro 
                405                 410                 415     


Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe 
            420                 425                 430         


Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly 
        435                 440                 445             


Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp 
    450                 455                 460                 


Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met 
465                 470                 475                 480 


Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp 
                485                 490                 495     


Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val 
            500                 505                 510         


Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln 
        515                 520                 525             


Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu 
    530                 535                 540                 


Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro 
545                 550                 555                 560 


Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly 
                565                 570                 575     


His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser 
            580                 585                 590         


Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly 
        595                 600                 605             


Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val 
    610                 615                 620                 


Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn 
625                 630                 635                 640 


Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala 
                645                 650                 655     


Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro 
            660                 665                 670         


His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val 
        675                 680                 685             


Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr 
    690                 695                 700                 


Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val 
705                 710                 715                 720 


Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr 
                725                 730                 735     


Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro 
            740                 745                 750         


Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln 
        755                 760                 765             


Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg 
    770                 775                 780                 


Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu 
785                 790                 795                 800 


Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly 
                805                 810                 815     


Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val 
            820                 825                 830         


Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn 
        835                 840                 845             


Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu 
    850                 855                 860                 


Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln 
865                 870                 875                 880 


Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp 
                885                 890                 895     


Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe 
            900                 905                 910         


Leu Val Ser Trp Cys 
        915         


<210>  28
<211>  883
<212>  PRT
<213>  artificial

<220>
<223>  hGAA-delta-42

<400>  28

Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro 
1               5                   10                  15      


Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu 
            20                  25                  30          


Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu 
        35                  40                  45              


Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr 
    50                  55                  60                  


Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr 
65                  70                  75                  80  


Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu 
                85                  90                  95      


Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe 
            100                 105                 110         


Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr 
        115                 120                 125             


Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe 
    130                 135                 140                 


Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg 
145                 150                 155                 160 


Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe 
                165                 170                 175     


Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala 
            180                 185                 190         


Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr 
        195                 200                 205             


Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly 
    210                 215                 220                 


Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly 
225                 230                 235                 240 


Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser 
                245                 250                 255     


Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile 
            260                 265                 270         


Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val 
        275                 280                 285             


Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu 
    290                 295                 300                 


Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu 
305                 310                 315                 320 


Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu 
                325                 330                 335     


Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe 
            340                 345                 350         


Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg 
        355                 360                 365             


Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly 
    370                 375                 380                 


Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr 
385                 390                 395                 400 


Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr 
                405                 410                 415     


Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp 
            420                 425                 430         


Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile 
        435                 440                 445             


Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys 
    450                 455                 460                 


Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly 
465                 470                 475                 480 


Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu 
                485                 490                 495     


Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile 
            500                 505                 510         


Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val 
        515                 520                 525             


Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp 
    530                 535                 540                 


Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro 
545                 550                 555                 560 


Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp 
                565                 570                 575     


Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp 
            580                 585                 590         


Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu 
        595                 600                 605             


Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln 
    610                 615                 620                 


Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu 
625                 630                 635                 640 


Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg 
                645                 650                 655     


Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp 
            660                 665                 670         


His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln 
        675                 680                 685             


Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr 
    690                 695                 700                 


Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro 
705                 710                 715                 720 


Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val 
                725                 730                 735     


Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly 
            740                 745                 750         


Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg 
        755                 760                 765             


Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala 
    770                 775                 780                 


Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu 
785                 790                 795                 800 


Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile 
                805                 810                 815     


Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu 
            820                 825                 830         


Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu 
        835                 840                 845             


Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys 
    850                 855                 860                 


Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val 
865                 870                 875                 880 


Ser Trp Cys 
            


<210>  29
<211>  952
<212>  PRT
<213>  homo sapiens

<400>  29

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  30
<211>  952
<212>  PRT
<213>  homo sapiens

<400>  30

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  31
<211>  957
<212>  PRT
<213>  homo sapiens

<400>  31

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Ala Arg Gly Pro Arg Val Leu Asp Ile Cys Val 
    930                 935                 940                 


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
945                 950                 955         


<210>  32
<211>  952
<212>  PRT
<213>  homo sapiens

<400>  32

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Leu Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  33
<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  variant hGAAwt w/o sp

<400>  33

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro Arg Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val His Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Ile Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  34
<211>  896
<212>  PRT
<213>  artificial

<220>
<223>  hGAA-delta-29

<400>  34

Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro 
1               5                   10                  15      


Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser 
            20                  25                  30          


Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu 
        35                  40                  45              


Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala 
    50                  55                  60                  


Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr 
65                  70                  75                  80  


Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu 
                85                  90                  95      


Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg 
            100                 105                 110         


Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys 
        115                 120                 125             


Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val 
    130                 135                 140                 


His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu 
145                 150                 155                 160 


Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu 
                165                 170                 175     


Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu 
            180                 185                 190         


Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu 
        195                 200                 205             


Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn 
    210                 215                 220                 


Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro 
225                 230                 235                 240 


Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu 
                245                 250                 255     


Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu 
            260                 265                 270         


Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly 
        275                 280                 285             


Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr 
    290                 295                 300                 


Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp 
305                 310                 315                 320 


Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr 
                325                 330                 335     


Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met 
            340                 345                 350         


Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe 
        355                 360                 365             


Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met 
    370                 375                 380                 


Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg 
385                 390                 395                 400 


Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr 
                405                 410                 415     


Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro 
            420                 425                 430         


Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala 
        435                 440                 445             


Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn 
    450                 455                 460                 


Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn 
465                 470                 475                 480 


Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu 
                485                 490                 495     


Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His 
            500                 505                 510         


Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His 
        515                 520                 525             


Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg 
    530                 535                 540                 


Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp 
545                 550                 555                 560 


Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu 
                565                 570                 575     


Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly 
            580                 585                 590         


Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu 
        595                 600                 605             


Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu 
    610                 615                 620                 


Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg 
625                 630                 635                 640 


Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu 
                645                 650                 655     


Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe 
            660                 665                 670         


Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu 
        675                 680                 685             


Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys 
    690                 695                 700                 


Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln 
705                 710                 715                 720 


Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala 
                725                 730                 735     


Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro 
            740                 745                 750         


Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile 
        755                 760                 765             


Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro 
    770                 775                 780                 


Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu 
785                 790                 795                 800 


Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala 
                805                 810                 815     


Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu 
            820                 825                 830         


Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val 
        835                 840                 845             


Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly 
    850                 855                 860                 


Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp 
865                 870                 875                 880 


Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890                 895     


<210>  35
<211>  882
<212>  PRT
<213>  artificial

<220>
<223>  hGAA-delta-43

<400>  35

His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro 
1               5                   10                  15      


Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln 
            20                  25                  30          


Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln 
        35                  40                  45              


Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro 
    50                  55                  60                  


Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala 
65                  70                  75                  80  


Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr 
                85                  90                  95      


Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr 
            100                 105                 110         


Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro 
        115                 120                 125             


His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser 
    130                 135                 140                 


Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val 
145                 150                 155                 160 


Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu 
                165                 170                 175     


Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu 
            180                 185                 190         


His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu 
        195                 200                 205             


Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser 
    210                 215                 220                 


His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val 
225                 230                 235                 240 


Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro 
                245                 250                 255     


Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe 
            260                 265                 270         


Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val 
        275                 280                 285             


Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys 
    290                 295                 300                 


Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn 
305                 310                 315                 320 


Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp 
                325                 330                 335     


Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg 
            340                 345                 350         


Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr 
        355                 360                 365             


Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser 
    370                 375                 380                 


Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn 
385                 390                 395                 400 


Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala 
                405                 410                 415     


Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met 
            420                 425                 430         


Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp 
        435                 440                 445             


Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro 
    450                 455                 460                 


Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly 
465                 470                 475                 480 


Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser 
                485                 490                 495     


Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala 
            500                 505                 510         


Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile 
        515                 520                 525             


Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr 
    530                 535                 540                 


Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu 
545                 550                 555                 560 


Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val 
                565                 570                 575     


Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr 
            580                 585                 590         


Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu 
        595                 600                 605             


Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala 
    610                 615                 620                 


Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr 
625                 630                 635                 640 


Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro 
                645                 650                 655     


Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His 
            660                 665                 670         


Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala 
        675                 680                 685             


Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp 
    690                 695                 700                 


Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro 
705                 710                 715                 720 


Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr 
                725                 730                 735     


Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr 
            740                 745                 750         


Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln 
        755                 760                 765             


Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg 
    770                 775                 780                 


Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg 
785                 790                 795                 800 


Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val 
                805                 810                 815     


Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln 
            820                 825                 830         


Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser 
        835                 840                 845             


Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val 
    850                 855                 860                 


Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser 
865                 870                 875                 880 


Trp Cys 
        


<210>  36
<211>  878
<212>  PRT
<213>  artificial

<220>
<223>  hGAA-delta-47

<400>  36

Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe 
1               5                   10                  15      


Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg 
            20                  25                  30          


Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met 
        35                  40                  45              


Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu 
    50                  55                  60                  


Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp 
                85                  90                  95      


Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro 
            100                 105                 110         


Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser 
        115                 120                 125             


Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe 
    130                 135                 140                 


Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr 
145                 150                 155                 160 


Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                165                 170                 175     


Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro 
            180                 185                 190         


Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp 
        195                 200                 205             


Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr 
    210                 215                 220                 


Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn 
225                 230                 235                 240 


Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp 
                245                 250                 255     


Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu 
            260                 265                 270         


Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe 
        275                 280                 285             


Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr 
    290                 295                 300                 


Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala 
305                 310                 315                 320 


His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser 
                325                 330                 335     


Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala 
            340                 345                 350         


Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val 
        355                 360                 365             


Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr 
    370                 375                 380                 


Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln 
385                 390                 395                 400 


Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe 
                405                 410                 415     


Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe 
            420                 425                 430         


His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro 
        435                 440                 445             


Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu 
    450                 455                 460                 


Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala 
465                 470                 475                 480 


Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn 
                485                 490                 495     


Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala 
            500                 505                 510         


Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr 
        515                 520                 525             


Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp 
    530                 535                 540                 


Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe 
545                 550                 555                 560 


Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu 
                565                 570                 575     


Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala 
            580                 585                 590         


Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln 
        595                 600                 605             


Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala 
    610                 615                 620                 


Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His 
625                 630                 635                 640 


Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu 
                645                 650                 655     


Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp 
            660                 665                 670         


Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu 
        675                 680                 685             


Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val 
    690                 695                 700                 


Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg 
705                 710                 715                 720 


Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro 
                725                 730                 735     


Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu 
            740                 745                 750         


Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala 
        755                 760                 765             


Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe 
    770                 775                 780                 


Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr 
785                 790                 795                 800 


Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val 
                805                 810                 815     


Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val 
            820                 825                 830         


Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro 
        835                 840                 845             


Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys 
    850                 855                 860                 


Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
865                 870                 875             


<210>  37
<211>  2745
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAwt-delta-29

<400>  37
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccagcag     60

ggagccagca gaccagggcc ccgggatgcc caggcacacc ccgggcggcc gcgagcagtg    120

cccacacagt gcgacgtccc ccccaacagc cgcttcgatt gcgcccctga caaggccatc    180

acccaggaac agtgcgaggc ccgcggctgt tgctacatcc ctgcaaagca ggggctgcag    240

ggagcccaga tggggcagcc ctggtgcttc ttcccaccca gctaccccag ctacaagctg    300

gagaacctga gctcctctga aatgggctac acggccaccc tgacccgtac cacccccacc    360

ttcttcccca aggacatcct gaccctgcgg ctggacgtga tgatggagac tgagaaccgc    420

ctccacttca cgatcaaaga tccagctaac aggcgctacg aggtgccctt ggagaccccg    480

catgtccaca gccgggcacc gtccccactc tacagcgtgg agttctccga ggagcccttc    540

ggggtgatcg tgcgccggca gctggacggc cgcgtgctgc tgaacacgac ggtggcgccc    600

ctgttctttg cggaccagtt ccttcagctg tccacctcgc tgccctcgca gtatatcaca    660

ggcctcgccg agcacctcag tcccctgatg ctcagcacca gctggaccag gatcaccctg    720

tggaaccggg accttgcgcc cacgcccggt gcgaacctct acgggtctca ccctttctac    780

ctggcgctgg aggacggcgg gtcggcacac ggggtgttcc tgctaaacag caatgccatg    840

gatgtggtcc tgcagccgag ccctgccctt agctggaggt cgacaggtgg gatcctggat    900

gtctacatct tcctgggccc agagcccaag agcgtggtgc agcagtacct ggacgttgtg    960

ggatacccgt tcatgccgcc atactggggc ctgggcttcc acctgtgccg ctggggctac   1020

tcctccaccg ctatcacccg ccaggtggtg gagaacatga ccagggccca cttccccctg   1080

gacgtccagt ggaacgacct ggactacatg gactcccgga gggacttcac gttcaacaag   1140

gatggcttcc gggacttccc ggccatggtg caggagctgc accagggcgg ccggcgctac   1200

atgatgatcg tggatcctgc catcagcagc tcgggccctg ccgggagcta caggccctac   1260

gacgagggtc tgcggagggg ggttttcatc accaacgaga ccggccagcc gctgattggg   1320

aaggtatggc ccgggtccac tgccttcccc gacttcacca accccacagc cctggcctgg   1380

tgggaggaca tggtggctga gttccatgac caggtgccct tcgacggcat gtggattgac   1440

atgaacgagc cttccaactt catcaggggc tctgaggacg gctgccccaa caatgagctg   1500

gagaacccac cctacgtgcc tggggtggtt ggggggaccc tccaggcggc caccatctgt   1560

gcctccagcc accagtttct ctccacacac tacaacctgc acaacctcta cggcctgacc   1620

gaagccatcg cctcccacag ggcgctggtg aaggctcggg ggacacgccc atttgtgatc   1680

tcccgctcga cctttgctgg ccacggccga tacgccggcc actggacggg ggacgtgtgg   1740

agctcctggg agcagctcgc ctcctccgtg ccagaaatcc tgcagtttaa cctgctgggg   1800

gtgcctctgg tcggggccga cgtctgcggc ttcctgggca acacctcaga ggagctgtgt   1860

gtgcgctgga cccagctggg ggccttctac cccttcatgc ggaaccacaa cagcctgctc   1920

agtctgcccc aggagccgta cagcttcagc gagccggccc agcaggccat gaggaaggcc   1980

ctcaccctgc gctacgcact cctcccccac ctctacacac tgttccacca ggcccacgtc   2040

gcgggggaga ccgtggcccg gcccctcttc ctggagttcc ccaaggactc tagcacctgg   2100

actgtggacc accagctcct gtggggggag gccctgctca tcaccccagt gctccaggcc   2160

gggaaggccg aagtgactgg ctacttcccc ttgggcacat ggtacgacct gcagacggtg   2220

ccagtagagg cccttggcag cctcccaccc ccacctgcag ctccccgtga gccagccatc   2280

cacagcgagg ggcagtgggt gacgctgccg gcccccctgg acaccatcaa cgtccacctc   2340

cgggctgggt acatcatccc cctgcagggc cctggcctca caaccacaga gtcccgccag   2400

cagcccatgg ccctggctgt ggccctgacc aagggtgggg aggcccgagg ggagctgttc   2460

tgggacgatg gagagagcct ggaagtgctg gagcgagggg cctacacaca ggtcatcttc   2520

ctggccagga ataacacgat cgtgaatgag ctggtacgtg tgaccagtga gggagctggc   2580

ctgcagctgc agaaggtgac tgtcctgggc gtggccacgg cgccccagca ggtcctctcc   2640

aacggtgtcc ctgtctccaa cttcacctac agccccgaca ccaaggtcct ggacatctgt   2700

gtctcgctgt tgatgggaga gcagtttctc gtcagctggt gttag                   2745


<210>  38
<211>  2745
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco1-delta-29

<400>  38
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccagcag     60

ggcgcctcta gacctggacc tagagatgcc caggcccacc ccggcagacc tagagctgtg    120

cctacccagt gtgacgtgcc ccccaacagc agattcgact gcgcccctga caaggccatc    180

acccaggaac agtgcgaggc cagaggctgc tgctacatcc ctgccaagca gggactgcag    240

ggcgctcaga tgggacagcc ctggtgcttc ttcccaccct cctaccccag ctacaagctg    300

gaaaacctga gcagcagcga gatgggctac accgccaccc tgaccagaac cacccccaca    360

ttcttcccaa aggacatcct gaccctgcgg ctggacgtga tgatggaaac cgagaaccgg    420

ctgcacttca ccatcaagga ccccgccaat cggagatacg aggtgcccct ggaaaccccc    480

cacgtgcact ctagagcccc cagccctctg tacagcgtgg aattcagcga ggaacccttc    540

ggcgtgatcg tgcggagaca gctggatggc agagtgctgc tgaacaccac cgtggcccct    600

ctgttcttcg ccgaccagtt cctgcagctg agcaccagcc tgcccagcca gtacatcaca    660

ggactggccg agcacctgag ccccctgatg ctgagcacat cctggacccg gatcaccctg    720

tggaacaggg atctggcccc tacccctggc gccaatctgt acggcagcca ccctttctac    780

ctggccctgg aagatggcgg atctgcccac ggagtgtttc tgctgaactc caacgccatg    840

gacgtggtgc tgcagcctag ccctgccctg tcttggagaa gcacaggcgg catcctggat    900

gtgtacatct ttctgggccc cgagcccaag agcgtggtgc agcagtatct ggatgtcgtg    960

ggctacccct tcatgccccc ttactggggc ctgggattcc acctgtgcag atggggctac   1020

tccagcaccg ccatcaccag acaggtggtg gaaaacatga ccagagccca cttcccactg   1080

gatgtgcagt ggaacgacct ggactacatg gacagcagac gggacttcac cttcaacaag   1140

gacggcttcc gggacttccc cgccatggtg caggaactgc atcagggcgg cagacggtac   1200

atgatgatcg tggatcccgc catcagctcc tctggccctg ccggctctta cagaccctac   1260

gacgagggcc tgcggagagg cgtgttcatc accaacgaga caggccagcc cctgatcggc   1320

aaagtgtggc ctggcagcac agccttcccc gacttcacca atcctaccgc cctggcttgg   1380

tgggaggaca tggtggccga gttccacgac caggtgccct tcgacggcat gtggatcgac   1440

atgaacgagc ccagcaactt catccggggc agcgaggatg gctgccccaa caacgaactg   1500

gaaaatcccc cttacgtgcc cggcgtcgtg ggcggaacac tgcaggccgc tacaatctgt   1560

gccagcagcc accagtttct gagcacccac tacaacctgc acaacctgta cggcctgacc   1620

gaggccattg ccagccaccg cgctctcgtg aaagccagag gcacacggcc cttcgtgatc   1680

agcagaagca cctttgccgg ccacggcaga tacgccggac attggactgg cgacgtgtgg   1740

tcctcttggg agcagctggc ctctagcgtg cccgagatcc tgcagttcaa tctgctgggc   1800

gtgccactcg tgggcgccga tgtgtgtggc ttcctgggca acacctccga ggaactgtgt   1860

gtgcggtgga cacagctggg cgccttctac cctttcatga gaaaccacaa cagcctgctg   1920

agcctgcccc aggaacccta cagctttagc gagcctgcac agcaggccat gcggaaggcc   1980

ctgacactga gatacgctct gctgccccac ctgtacaccc tgtttcacca ggcccatgtg   2040

gccggcgaga cagtggccag acctctgttt ctggaattcc ccaaggacag cagcacctgg   2100

accgtggacc atcagctgct gtggggagag gctctgctga ttaccccagt gctgcaggca   2160

ggcaaggccg aagtgaccgg ctactttccc ctgggcactt ggtacgacct gcagaccgtg   2220

cctgtggaag ccctgggatc tctgcctcca cctcctgccg ctcctagaga gcctgccatt   2280

cactctgagg gccagtgggt cacactgcct gcccccctgg ataccatcaa cgtgcacctg   2340

agggccggct acatcatacc actgcaggga cctggcctga ccaccaccga gtctagacag   2400

cagccaatgg ccctggccgt ggccctgacc aaaggcggag aagctagggg cgagctgttc   2460

tgggacgatg gcgagagcct ggaagtgctg gaaagaggcg cctataccca agtgatcttc   2520

ctggcccgga acaacaccat cgtgaacgag ctggtgcgcg tgacctctga aggcgctgga   2580

ctgcagctgc agaaagtgac cgtgctggga gtggccacag cccctcagca ggtgctgtct   2640

aatggcgtgc ccgtgtccaa cttcacctac agccccgaca ccaaggtgct ggacatctgc   2700

gtgtcactgc tgatgggaga gcagtttctg gtgtcctggt gctga                   2745


<210>  39
<211>  2745
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco2-delta-29

<400>  39
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccaacag     60

ggagcttcca gaccaggacc gagagacgcc caagcccatc ctggtagacc aagagctgtg    120

cctacccaat gcgacgtgcc acccaactcc cgattcgact gcgcgccaga taaggctatt    180

acccaagagc agtgtgaagc cagaggttgc tgctacatcc cagcgaagca aggattgcaa    240

ggcgcccaaa tgggacaacc ttggtgtttc ttcccccctt cgtacccatc atataaactc    300

gaaaacctgt cctcttcgga aatgggttat actgccaccc tcaccagaac tactcctact    360

ttcttcccga aagacatctt gaccttgagg ctggacgtga tgatggagac tgaaaaccgg    420

ctgcatttca ctatcaaaga tcctgccaat cggcgatacg aggtccctct ggaaacccct    480

cacgtgcact cacgggctcc ttctccgctt tactccgtcg aattctctga ggaacccttc    540

ggagtgatcg ttagacgcca gctggatggt agagtgctgt tgaacactac tgtggcccca    600

cttttcttcg ctgaccagtt tctgcaactg tccacttccc tgccatccca gtacattact    660

ggactcgccg aacacctgtc gccactgatg ctctcgacct cttggactag aatcactttg    720

tggaacagag acttggcccc tactccggga gcaaatctgt acggaagcca ccctttttac    780

ctggcgctcg aagatggcgg atccgctcac ggagtgttcc tgctgaatag caacgcaatg    840

gacgtggtgc tgcaaccttc ccctgcactc agttggagaa gtaccggggg tattctggac    900

gtgtacatct tcctcggacc agaacccaag agcgtggtgc agcaatatct ggacgtggtc    960

ggataccctt ttatgcctcc ttactgggga ctgggattcc acctttgccg ttggggctac   1020

tcatccaccg ccattaccag acaggtggtg gagaatatga ccagagccca cttccctctc   1080

gacgtgcagt ggaacgatct ggactatatg gactcccgga gagatttcac cttcaacaag   1140

gacgggttcc gcgattttcc cgcgatggtt caagagctcc accagggtgg tcgaagatat   1200

atgatgatcg tcgacccagc catttcgagc agcggacccg ctggatctta tagaccttac   1260

gacgaaggcc ttaggagagg agtgttcatc acaaacgaga ctggacagcc tttgatcggt   1320

aaagtgtggc ctggatcaac cgcctttcct gactttacca atcccactgc cttggcttgg   1380

tgggaggaca tggtggccga attccacgac caagtcccct ttgatggaat gtggatcgat   1440

atgaacgaac caagcaattt tatcagaggt tccgaagacg gttgccccaa caacgaactg   1500

gaaaaccctc cttatgtgcc cggagtcgtg ggcggaacat tacaggccgc gactatttgc   1560

gccagcagcc accaattcct gtccactcac tacaacctcc acaaccttta tggattaacc   1620

gaagctattg caagtcacag ggctctggtg aaggctagag ggactaggcc ctttgtgatc   1680

tcccgatcca cctttgccgg acacgggaga tacgccggtc actggactgg tgacgtgtgg   1740

agctcatggg aacaactggc ctcctccgtg ccggaaatct tacagttcaa ccttctgggt   1800

gtccctcttg tcggagcaga cgtgtgtggg tttcttggta acacctccga ggaactgtgt   1860

gtgcgctgga ctcaactggg tgcattctac ccattcatga gaaaccacaa ctccttgctg   1920

tccctgccac aagagcccta ctcgttcagc gagcctgcac aacaggctat gcggaaggca   1980

ctgaccctga gatacgccct gcttccacac ttatacactc tcttccatca agcgcatgtg   2040

gcaggagaaa ccgttgcaag gcctcttttc cttgaattcc ccaaggattc ctcgacttgg   2100

acggtggatc atcagctgct gtggggagaa gctctgctga ttactccagt gttgcaagcc   2160

ggaaaagctg aggtgaccgg atactttccg ctgggaacct ggtacgacct ccagactgtc   2220

cctgttgaag cccttggatc actgcctccg cctccggcag ctccacgcga accagctata   2280

cattccgagg gacagtgggt tacattacca gctcctctgg acacaatcaa cgtccactta   2340

agagctggct acattatccc tctgcaagga ccaggactga ctacgaccga gagcagacag   2400

cagccaatgg cactggctgt ggctctgacc aagggagggg aagctagagg agaactcttc   2460

tgggatgatg gggagtccct tgaagtgctg gaaagaggcg cttacactca agtcattttc   2520

cttgcacgga acaacaccat tgtgaacgaa ttggtgcgag tgaccagcga aggagctgga   2580

cttcaactgc agaaggtcac tgtgctcgga gtggctaccg ctcctcagca agtgctgtcg   2640

aatggagtcc ccgtgtcaaa ctttacctac tcccctgaca ctaaggtgct cgacatttgc   2700

gtgtccctcc tgatgggaga gcagttcctt gtgtcctggt gttga                   2745


<210>  40
<211>  2706
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAwt-delta-42

<400>  40
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcgcacac     60

cccgggcggc cgcgagcagt gcccacacag tgcgacgtcc cccccaacag ccgcttcgat    120

tgcgcccctg acaaggccat cacccaggaa cagtgcgagg cccgcggctg ttgctacatc    180

cctgcaaagc aggggctgca gggagcccag atggggcagc cctggtgctt cttcccaccc    240

agctacccca gctacaagct ggagaacctg agctcctctg aaatgggcta cacggccacc    300

ctgacccgta ccacccccac cttcttcccc aaggacatcc tgaccctgcg gctggacgtg    360

atgatggaga ctgagaaccg cctccacttc acgatcaaag atccagctaa caggcgctac    420

gaggtgccct tggagacccc gcatgtccac agccgggcac cgtccccact ctacagcgtg    480

gagttctccg aggagccctt cggggtgatc gtgcgccggc agctggacgg ccgcgtgctg    540

ctgaacacga cggtggcgcc cctgttcttt gcggaccagt tccttcagct gtccacctcg    600

ctgccctcgc agtatatcac aggcctcgcc gagcacctca gtcccctgat gctcagcacc    660

agctggacca ggatcaccct gtggaaccgg gaccttgcgc ccacgcccgg tgcgaacctc    720

tacgggtctc accctttcta cctggcgctg gaggacggcg ggtcggcaca cggggtgttc    780

ctgctaaaca gcaatgccat ggatgtggtc ctgcagccga gccctgccct tagctggagg    840

tcgacaggtg ggatcctgga tgtctacatc ttcctgggcc cagagcccaa gagcgtggtg    900

cagcagtacc tggacgttgt gggatacccg ttcatgccgc catactgggg cctgggcttc    960

cacctgtgcc gctggggcta ctcctccacc gctatcaccc gccaggtggt ggagaacatg   1020

accagggccc acttccccct ggacgtccag tggaacgacc tggactacat ggactcccgg   1080

agggacttca cgttcaacaa ggatggcttc cgggacttcc cggccatggt gcaggagctg   1140

caccagggcg gccggcgcta catgatgatc gtggatcctg ccatcagcag ctcgggccct   1200

gccgggagct acaggcccta cgacgagggt ctgcggaggg gggttttcat caccaacgag   1260

accggccagc cgctgattgg gaaggtatgg cccgggtcca ctgccttccc cgacttcacc   1320

aaccccacag ccctggcctg gtgggaggac atggtggctg agttccatga ccaggtgccc   1380

ttcgacggca tgtggattga catgaacgag ccttccaact tcatcagggg ctctgaggac   1440

ggctgcccca acaatgagct ggagaaccca ccctacgtgc ctggggtggt tggggggacc   1500

ctccaggcgg ccaccatctg tgcctccagc caccagtttc tctccacaca ctacaacctg   1560

cacaacctct acggcctgac cgaagccatc gcctcccaca gggcgctggt gaaggctcgg   1620

gggacacgcc catttgtgat ctcccgctcg acctttgctg gccacggccg atacgccggc   1680

cactggacgg gggacgtgtg gagctcctgg gagcagctcg cctcctccgt gccagaaatc   1740

ctgcagttta acctgctggg ggtgcctctg gtcggggccg acgtctgcgg cttcctgggc   1800

aacacctcag aggagctgtg tgtgcgctgg acccagctgg gggccttcta ccccttcatg   1860

cggaaccaca acagcctgct cagtctgccc caggagccgt acagcttcag cgagccggcc   1920

cagcaggcca tgaggaaggc cctcaccctg cgctacgcac tcctccccca cctctacaca   1980

ctgttccacc aggcccacgt cgcgggggag accgtggccc ggcccctctt cctggagttc   2040

cccaaggact ctagcacctg gactgtggac caccagctcc tgtgggggga ggccctgctc   2100

atcaccccag tgctccaggc cgggaaggcc gaagtgactg gctacttccc cttgggcaca   2160

tggtacgacc tgcagacggt gccagtagag gcccttggca gcctcccacc cccacctgca   2220

gctccccgtg agccagccat ccacagcgag gggcagtggg tgacgctgcc ggcccccctg   2280

gacaccatca acgtccacct ccgggctggg tacatcatcc ccctgcaggg ccctggcctc   2340

acaaccacag agtcccgcca gcagcccatg gccctggctg tggccctgac caagggtggg   2400

gaggcccgag gggagctgtt ctgggacgat ggagagagcc tggaagtgct ggagcgaggg   2460

gcctacacac aggtcatctt cctggccagg aataacacga tcgtgaatga gctggtacgt   2520

gtgaccagtg agggagctgg cctgcagctg cagaaggtga ctgtcctggg cgtggccacg   2580

gcgccccagc aggtcctctc caacggtgtc cctgtctcca acttcaccta cagccccgac   2640

accaaggtcc tggacatctg tgtctcgctg ttgatgggag agcagtttct cgtcagctgg   2700

tgttag                                                              2706


<210>  41
<211>  2706
<212>  DNA
<213>  artificial

<220>
<223>  sp7-hGAAco2-delta-42

<400>  41
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcgcccat     60

cctggtagac caagagctgt gcctacccaa tgcgacgtgc cacccaactc ccgattcgac    120

tgcgcgccag ataaggctat tacccaagag cagtgtgaag ccagaggttg ctgctacatc    180

ccagcgaagc aaggattgca aggcgcccaa atgggacaac cttggtgttt cttcccccct    240

tcgtacccat catataaact cgaaaacctg tcctcttcgg aaatgggtta tactgccacc    300

ctcaccagaa ctactcctac tttcttcccg aaagacatct tgaccttgag gctggacgtg    360

atgatggaga ctgaaaaccg gctgcatttc actatcaaag atcctgccaa tcggcgatac    420

gaggtccctc tggaaacccc tcacgtgcac tcacgggctc cttctccgct ttactccgtc    480

gaattctctg aggaaccctt cggagtgatc gttagacgcc agctggatgg tagagtgctg    540

ttgaacacta ctgtggcccc acttttcttc gctgaccagt ttctgcaact gtccacttcc    600

ctgccatccc agtacattac tggactcgcc gaacacctgt cgccactgat gctctcgacc    660

tcttggacta gaatcacttt gtggaacaga gacttggccc ctactccggg agcaaatctg    720

tacggaagcc acccttttta cctggcgctc gaagatggcg gatccgctca cggagtgttc    780

ctgctgaata gcaacgcaat ggacgtggtg ctgcaacctt cccctgcact cagttggaga    840

agtaccgggg gtattctgga cgtgtacatc ttcctcggac cagaacccaa gagcgtggtg    900

cagcaatatc tggacgtggt cggataccct tttatgcctc cttactgggg actgggattc    960

cacctttgcc gttggggcta ctcatccacc gccattacca gacaggtggt ggagaatatg   1020

accagagccc acttccctct cgacgtgcag tggaacgatc tggactatat ggactcccgg   1080

agagatttca ccttcaacaa ggacgggttc cgcgattttc ccgcgatggt tcaagagctc   1140

caccagggtg gtcgaagata tatgatgatc gtcgacccag ccatttcgag cagcggaccc   1200

gctggatctt atagacctta cgacgaaggc cttaggagag gagtgttcat cacaaacgag   1260

actggacagc ctttgatcgg taaagtgtgg cctggatcaa ccgcctttcc tgactttacc   1320

aatcccactg ccttggcttg gtgggaggac atggtggccg aattccacga ccaagtcccc   1380

tttgatggaa tgtggatcga tatgaacgaa ccaagcaatt ttatcagagg ttccgaagac   1440

ggttgcccca acaacgaact ggaaaaccct ccttatgtgc ccggagtcgt gggcggaaca   1500

ttacaggccg cgactatttg cgccagcagc caccaattcc tgtccactca ctacaacctc   1560

cacaaccttt atggattaac cgaagctatt gcaagtcaca gggctctggt gaaggctaga   1620

gggactaggc cctttgtgat ctcccgatcc acctttgccg gacacgggag atacgccggt   1680

cactggactg gtgacgtgtg gagctcatgg gaacaactgg cctcctccgt gccggaaatc   1740

ttacagttca accttctggg tgtccctctt gtcggagcag acgtgtgtgg gtttcttggt   1800

aacacctccg aggaactgtg tgtgcgctgg actcaactgg gtgcattcta cccattcatg   1860

agaaaccaca actccttgct gtccctgcca caagagccct actcgttcag cgagcctgca   1920

caacaggcta tgcggaaggc actgaccctg agatacgccc tgcttccaca cttatacact   1980

ctcttccatc aagcgcatgt ggcaggagaa accgttgcaa ggcctctttt ccttgaattc   2040

cccaaggatt cctcgacttg gacggtggat catcagctgc tgtggggaga agctctgctg   2100

attactccag tgttgcaagc cggaaaagct gaggtgaccg gatactttcc gctgggaacc   2160

tggtacgacc tccagactgt ccctgttgaa gcccttggat cactgcctcc gcctccggca   2220

gctccacgcg aaccagctat acattccgag ggacagtggg ttacattacc agctcctctg   2280

gacacaatca acgtccactt aagagctggc tacattatcc ctctgcaagg accaggactg   2340

actacgaccg agagcagaca gcagccaatg gcactggctg tggctctgac caagggaggg   2400

gaagctagag gagaactctt ctgggatgat ggggagtccc ttgaagtgct ggaaagaggc   2460

gcttacactc aagtcatttt ccttgcacgg aacaacacca ttgtgaacga attggtgcga   2520

gtgaccagcg aaggagctgg acttcaactg cagaaggtca ctgtgctcgg agtggctacc   2580

gctcctcagc aagtgctgtc gaatggagtc cccgtgtcaa actttaccta ctcccctgac   2640

actaaggtgc tcgacatttg cgtgtccctc ctgatgggag agcagttcct tgtgtcctgg   2700

tgttga                                                              2706


<210>  42
<211>  2703
<212>  DNA
<213>  artificial

<220>
<223>  sp7-hGAAwt-delta-43

<400>  42
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccacccc     60

gggcggccgc gagcagtgcc cacacagtgc gacgtccccc ccaacagccg cttcgattgc    120

gcccctgaca aggccatcac ccaggaacag tgcgaggccc gcggctgttg ctacatccct    180

gcaaagcagg ggctgcaggg agcccagatg gggcagccct ggtgcttctt cccacccagc    240

taccccagct acaagctgga gaacctgagc tcctctgaaa tgggctacac ggccaccctg    300

acccgtacca cccccacctt cttccccaag gacatcctga ccctgcggct ggacgtgatg    360

atggagactg agaaccgcct ccacttcacg atcaaagatc cagctaacag gcgctacgag    420

gtgcccttgg agaccccgca tgtccacagc cgggcaccgt ccccactcta cagcgtggag    480

ttctccgagg agcccttcgg ggtgatcgtg cgccggcagc tggacggccg cgtgctgctg    540

aacacgacgg tggcgcccct gttctttgcg gaccagttcc ttcagctgtc cacctcgctg    600

ccctcgcagt atatcacagg cctcgccgag cacctcagtc ccctgatgct cagcaccagc    660

tggaccagga tcaccctgtg gaaccgggac cttgcgccca cgcccggtgc gaacctctac    720

gggtctcacc ctttctacct ggcgctggag gacggcgggt cggcacacgg ggtgttcctg    780

ctaaacagca atgccatgga tgtggtcctg cagccgagcc ctgcccttag ctggaggtcg    840

acaggtggga tcctggatgt ctacatcttc ctgggcccag agcccaagag cgtggtgcag    900

cagtacctgg acgttgtggg atacccgttc atgccgccat actggggcct gggcttccac    960

ctgtgccgct ggggctactc ctccaccgct atcacccgcc aggtggtgga gaacatgacc   1020

agggcccact tccccctgga cgtccagtgg aacgacctgg actacatgga ctcccggagg   1080

gacttcacgt tcaacaagga tggcttccgg gacttcccgg ccatggtgca ggagctgcac   1140

cagggcggcc ggcgctacat gatgatcgtg gatcctgcca tcagcagctc gggccctgcc   1200

gggagctaca ggccctacga cgagggtctg cggagggggg ttttcatcac caacgagacc   1260

ggccagccgc tgattgggaa ggtatggccc gggtccactg ccttccccga cttcaccaac   1320

cccacagccc tggcctggtg ggaggacatg gtggctgagt tccatgacca ggtgcccttc   1380

gacggcatgt ggattgacat gaacgagcct tccaacttca tcaggggctc tgaggacggc   1440

tgccccaaca atgagctgga gaacccaccc tacgtgcctg gggtggttgg ggggaccctc   1500

caggcggcca ccatctgtgc ctccagccac cagtttctct ccacacacta caacctgcac   1560

aacctctacg gcctgaccga agccatcgcc tcccacaggg cgctggtgaa ggctcggggg   1620

acacgcccat ttgtgatctc ccgctcgacc tttgctggcc acggccgata cgccggccac   1680

tggacggggg acgtgtggag ctcctgggag cagctcgcct cctccgtgcc agaaatcctg   1740

cagtttaacc tgctgggggt gcctctggtc ggggccgacg tctgcggctt cctgggcaac   1800

acctcagagg agctgtgtgt gcgctggacc cagctggggg ccttctaccc cttcatgcgg   1860

aaccacaaca gcctgctcag tctgccccag gagccgtaca gcttcagcga gccggcccag   1920

caggccatga ggaaggccct caccctgcgc tacgcactcc tcccccacct ctacacactg   1980

ttccaccagg cccacgtcgc gggggagacc gtggcccggc ccctcttcct ggagttcccc   2040

aaggactcta gcacctggac tgtggaccac cagctcctgt ggggggaggc cctgctcatc   2100

accccagtgc tccaggccgg gaaggccgaa gtgactggct acttcccctt gggcacatgg   2160

tacgacctgc agacggtgcc agtagaggcc cttggcagcc tcccaccccc acctgcagct   2220

ccccgtgagc cagccatcca cagcgagggg cagtgggtga cgctgccggc ccccctggac   2280

accatcaacg tccacctccg ggctgggtac atcatccccc tgcagggccc tggcctcaca   2340

accacagagt cccgccagca gcccatggcc ctggctgtgg ccctgaccaa gggtggggag   2400

gcccgagggg agctgttctg ggacgatgga gagagcctgg aagtgctgga gcgaggggcc   2460

tacacacagg tcatcttcct ggccaggaat aacacgatcg tgaatgagct ggtacgtgtg   2520

accagtgagg gagctggcct gcagctgcag aaggtgactg tcctgggcgt ggccacggcg   2580

ccccagcagg tcctctccaa cggtgtccct gtctccaact tcacctacag ccccgacacc   2640

aaggtcctgg acatctgtgt ctcgctgttg atgggagagc agtttctcgt cagctggtgt   2700

tag                                                                 2703


<210>  43
<211>  2703
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco1-delta-43

<400>  43
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccacccc     60

ggcagaccta gagctgtgcc tacccagtgt gacgtgcccc ccaacagcag attcgactgc    120

gcccctgaca aggccatcac ccaggaacag tgcgaggcca gaggctgctg ctacatccct    180

gccaagcagg gactgcaggg cgctcagatg ggacagccct ggtgcttctt cccaccctcc    240

taccccagct acaagctgga aaacctgagc agcagcgaga tgggctacac cgccaccctg    300

accagaacca cccccacatt cttcccaaag gacatcctga ccctgcggct ggacgtgatg    360

atggaaaccg agaaccggct gcacttcacc atcaaggacc ccgccaatcg gagatacgag    420

gtgcccctgg aaacccccca cgtgcactct agagccccca gccctctgta cagcgtggaa    480

ttcagcgagg aacccttcgg cgtgatcgtg cggagacagc tggatggcag agtgctgctg    540

aacaccaccg tggcccctct gttcttcgcc gaccagttcc tgcagctgag caccagcctg    600

cccagccagt acatcacagg actggccgag cacctgagcc ccctgatgct gagcacatcc    660

tggacccgga tcaccctgtg gaacagggat ctggccccta cccctggcgc caatctgtac    720

ggcagccacc ctttctacct ggccctggaa gatggcggat ctgcccacgg agtgtttctg    780

ctgaactcca acgccatgga cgtggtgctg cagcctagcc ctgccctgtc ttggagaagc    840

acaggcggca tcctggatgt gtacatcttt ctgggccccg agcccaagag cgtggtgcag    900

cagtatctgg atgtcgtggg ctaccccttc atgccccctt actggggcct gggattccac    960

ctgtgcagat ggggctactc cagcaccgcc atcaccagac aggtggtgga aaacatgacc   1020

agagcccact tcccactgga tgtgcagtgg aacgacctgg actacatgga cagcagacgg   1080

gacttcacct tcaacaagga cggcttccgg gacttccccg ccatggtgca ggaactgcat   1140

cagggcggca gacggtacat gatgatcgtg gatcccgcca tcagctcctc tggccctgcc   1200

ggctcttaca gaccctacga cgagggcctg cggagaggcg tgttcatcac caacgagaca   1260

ggccagcccc tgatcggcaa agtgtggcct ggcagcacag ccttccccga cttcaccaat   1320

cctaccgccc tggcttggtg ggaggacatg gtggccgagt tccacgacca ggtgcccttc   1380

gacggcatgt ggatcgacat gaacgagccc agcaacttca tccggggcag cgaggatggc   1440

tgccccaaca acgaactgga aaatccccct tacgtgcccg gcgtcgtggg cggaacactg   1500

caggccgcta caatctgtgc cagcagccac cagtttctga gcacccacta caacctgcac   1560

aacctgtacg gcctgaccga ggccattgcc agccaccgcg ctctcgtgaa agccagaggc   1620

acacggccct tcgtgatcag cagaagcacc tttgccggcc acggcagata cgccggacat   1680

tggactggcg acgtgtggtc ctcttgggag cagctggcct ctagcgtgcc cgagatcctg   1740

cagttcaatc tgctgggcgt gccactcgtg ggcgccgatg tgtgtggctt cctgggcaac   1800

acctccgagg aactgtgtgt gcggtggaca cagctgggcg ccttctaccc tttcatgaga   1860

aaccacaaca gcctgctgag cctgccccag gaaccctaca gctttagcga gcctgcacag   1920

caggccatgc ggaaggccct gacactgaga tacgctctgc tgccccacct gtacaccctg   1980

tttcaccagg cccatgtggc cggcgagaca gtggccagac ctctgtttct ggaattcccc   2040

aaggacagca gcacctggac cgtggaccat cagctgctgt ggggagaggc tctgctgatt   2100

accccagtgc tgcaggcagg caaggccgaa gtgaccggct actttcccct gggcacttgg   2160

tacgacctgc agaccgtgcc tgtggaagcc ctgggatctc tgcctccacc tcctgccgct   2220

cctagagagc ctgccattca ctctgagggc cagtgggtca cactgcctgc ccccctggat   2280

accatcaacg tgcacctgag ggccggctac atcataccac tgcagggacc tggcctgacc   2340

accaccgagt ctagacagca gccaatggcc ctggccgtgg ccctgaccaa aggcggagaa   2400

gctaggggcg agctgttctg ggacgatggc gagagcctgg aagtgctgga aagaggcgcc   2460

tatacccaag tgatcttcct ggcccggaac aacaccatcg tgaacgagct ggtgcgcgtg   2520

acctctgaag gcgctggact gcagctgcag aaagtgaccg tgctgggagt ggccacagcc   2580

cctcagcagg tgctgtctaa tggcgtgccc gtgtccaact tcacctacag ccccgacacc   2640

aaggtgctgg acatctgcgt gtcactgctg atgggagagc agtttctggt gtcctggtgc   2700

tga                                                                 2703


<210>  44
<211>  2703
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco2-delta-43

<400>  44
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccatcct     60

ggtagaccaa gagctgtgcc tacccaatgc gacgtgccac ccaactcccg attcgactgc    120

gcgccagata aggctattac ccaagagcag tgtgaagcca gaggttgctg ctacatccca    180

gcgaagcaag gattgcaagg cgcccaaatg ggacaacctt ggtgtttctt ccccccttcg    240

tacccatcat ataaactcga aaacctgtcc tcttcggaaa tgggttatac tgccaccctc    300

accagaacta ctcctacttt cttcccgaaa gacatcttga ccttgaggct ggacgtgatg    360

atggagactg aaaaccggct gcatttcact atcaaagatc ctgccaatcg gcgatacgag    420

gtccctctgg aaacccctca cgtgcactca cgggctcctt ctccgcttta ctccgtcgaa    480

ttctctgagg aacccttcgg agtgatcgtt agacgccagc tggatggtag agtgctgttg    540

aacactactg tggccccact tttcttcgct gaccagtttc tgcaactgtc cacttccctg    600

ccatcccagt acattactgg actcgccgaa cacctgtcgc cactgatgct ctcgacctct    660

tggactagaa tcactttgtg gaacagagac ttggccccta ctccgggagc aaatctgtac    720

ggaagccacc ctttttacct ggcgctcgaa gatggcggat ccgctcacgg agtgttcctg    780

ctgaatagca acgcaatgga cgtggtgctg caaccttccc ctgcactcag ttggagaagt    840

accgggggta ttctggacgt gtacatcttc ctcggaccag aacccaagag cgtggtgcag    900

caatatctgg acgtggtcgg ataccctttt atgcctcctt actggggact gggattccac    960

ctttgccgtt ggggctactc atccaccgcc attaccagac aggtggtgga gaatatgacc   1020

agagcccact tccctctcga cgtgcagtgg aacgatctgg actatatgga ctcccggaga   1080

gatttcacct tcaacaagga cgggttccgc gattttcccg cgatggttca agagctccac   1140

cagggtggtc gaagatatat gatgatcgtc gacccagcca tttcgagcag cggacccgct   1200

ggatcttata gaccttacga cgaaggcctt aggagaggag tgttcatcac aaacgagact   1260

ggacagcctt tgatcggtaa agtgtggcct ggatcaaccg cctttcctga ctttaccaat   1320

cccactgcct tggcttggtg ggaggacatg gtggccgaat tccacgacca agtccccttt   1380

gatggaatgt ggatcgatat gaacgaacca agcaatttta tcagaggttc cgaagacggt   1440

tgccccaaca acgaactgga aaaccctcct tatgtgcccg gagtcgtggg cggaacatta   1500

caggccgcga ctatttgcgc cagcagccac caattcctgt ccactcacta caacctccac   1560

aacctttatg gattaaccga agctattgca agtcacaggg ctctggtgaa ggctagaggg   1620

actaggccct ttgtgatctc ccgatccacc tttgccggac acgggagata cgccggtcac   1680

tggactggtg acgtgtggag ctcatgggaa caactggcct cctccgtgcc ggaaatctta   1740

cagttcaacc ttctgggtgt ccctcttgtc ggagcagacg tgtgtgggtt tcttggtaac   1800

acctccgagg aactgtgtgt gcgctggact caactgggtg cattctaccc attcatgaga   1860

aaccacaact ccttgctgtc cctgccacaa gagccctact cgttcagcga gcctgcacaa   1920

caggctatgc ggaaggcact gaccctgaga tacgccctgc ttccacactt atacactctc   1980

ttccatcaag cgcatgtggc aggagaaacc gttgcaaggc ctcttttcct tgaattcccc   2040

aaggattcct cgacttggac ggtggatcat cagctgctgt ggggagaagc tctgctgatt   2100

actccagtgt tgcaagccgg aaaagctgag gtgaccggat actttccgct gggaacctgg   2160

tacgacctcc agactgtccc tgttgaagcc cttggatcac tgcctccgcc tccggcagct   2220

ccacgcgaac cagctataca ttccgaggga cagtgggtta cattaccagc tcctctggac   2280

acaatcaacg tccacttaag agctggctac attatccctc tgcaaggacc aggactgact   2340

acgaccgaga gcagacagca gccaatggca ctggctgtgg ctctgaccaa gggaggggaa   2400

gctagaggag aactcttctg ggatgatggg gagtcccttg aagtgctgga aagaggcgct   2460

tacactcaag tcattttcct tgcacggaac aacaccattg tgaacgaatt ggtgcgagtg   2520

accagcgaag gagctggact tcaactgcag aaggtcactg tgctcggagt ggctaccgct   2580

cctcagcaag tgctgtcgaa tggagtcccc gtgtcaaact ttacctactc ccctgacact   2640

aaggtgctcg acatttgcgt gtccctcctg atgggagagc agttccttgt gtcctggtgt   2700

tga                                                                 2703


<210>  45
<211>  2691
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAwt-delta-47

<400>  45
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcccgcga     60

gcagtgccca cacagtgcga cgtccccccc aacagccgct tcgattgcgc ccctgacaag    120

gccatcaccc aggaacagtg cgaggcccgc ggctgttgct acatccctgc aaagcagggg    180

ctgcagggag cccagatggg gcagccctgg tgcttcttcc cacccagcta ccccagctac    240

aagctggaga acctgagctc ctctgaaatg ggctacacgg ccaccctgac ccgtaccacc    300

cccaccttct tccccaagga catcctgacc ctgcggctgg acgtgatgat ggagactgag    360

aaccgcctcc acttcacgat caaagatcca gctaacaggc gctacgaggt gcccttggag    420

accccgcatg tccacagccg ggcaccgtcc ccactctaca gcgtggagtt ctccgaggag    480

cccttcgggg tgatcgtgcg ccggcagctg gacggccgcg tgctgctgaa cacgacggtg    540

gcgcccctgt tctttgcgga ccagttcctt cagctgtcca cctcgctgcc ctcgcagtat    600

atcacaggcc tcgccgagca cctcagtccc ctgatgctca gcaccagctg gaccaggatc    660

accctgtgga accgggacct tgcgcccacg cccggtgcga acctctacgg gtctcaccct    720

ttctacctgg cgctggagga cggcgggtcg gcacacgggg tgttcctgct aaacagcaat    780

gccatggatg tggtcctgca gccgagccct gcccttagct ggaggtcgac aggtgggatc    840

ctggatgtct acatcttcct gggcccagag cccaagagcg tggtgcagca gtacctggac    900

gttgtgggat acccgttcat gccgccatac tggggcctgg gcttccacct gtgccgctgg    960

ggctactcct ccaccgctat cacccgccag gtggtggaga acatgaccag ggcccacttc   1020

cccctggacg tccagtggaa cgacctggac tacatggact cccggaggga cttcacgttc   1080

aacaaggatg gcttccggga cttcccggcc atggtgcagg agctgcacca gggcggccgg   1140

cgctacatga tgatcgtgga tcctgccatc agcagctcgg gccctgccgg gagctacagg   1200

ccctacgacg agggtctgcg gaggggggtt ttcatcacca acgagaccgg ccagccgctg   1260

attgggaagg tatggcccgg gtccactgcc ttccccgact tcaccaaccc cacagccctg   1320

gcctggtggg aggacatggt ggctgagttc catgaccagg tgcccttcga cggcatgtgg   1380

attgacatga acgagccttc caacttcatc aggggctctg aggacggctg ccccaacaat   1440

gagctggaga acccacccta cgtgcctggg gtggttgggg ggaccctcca ggcggccacc   1500

atctgtgcct ccagccacca gtttctctcc acacactaca acctgcacaa cctctacggc   1560

ctgaccgaag ccatcgcctc ccacagggcg ctggtgaagg ctcgggggac acgcccattt   1620

gtgatctccc gctcgacctt tgctggccac ggccgatacg ccggccactg gacgggggac   1680

gtgtggagct cctgggagca gctcgcctcc tccgtgccag aaatcctgca gtttaacctg   1740

ctgggggtgc ctctggtcgg ggccgacgtc tgcggcttcc tgggcaacac ctcagaggag   1800

ctgtgtgtgc gctggaccca gctgggggcc ttctacccct tcatgcggaa ccacaacagc   1860

ctgctcagtc tgccccagga gccgtacagc ttcagcgagc cggcccagca ggccatgagg   1920

aaggccctca ccctgcgcta cgcactcctc ccccacctct acacactgtt ccaccaggcc   1980

cacgtcgcgg gggagaccgt ggcccggccc ctcttcctgg agttccccaa ggactctagc   2040

acctggactg tggaccacca gctcctgtgg ggggaggccc tgctcatcac cccagtgctc   2100

caggccggga aggccgaagt gactggctac ttccccttgg gcacatggta cgacctgcag   2160

acggtgccag tagaggccct tggcagcctc ccacccccac ctgcagctcc ccgtgagcca   2220

gccatccaca gcgaggggca gtgggtgacg ctgccggccc ccctggacac catcaacgtc   2280

cacctccggg ctgggtacat catccccctg cagggccctg gcctcacaac cacagagtcc   2340

cgccagcagc ccatggccct ggctgtggcc ctgaccaagg gtggggaggc ccgaggggag   2400

ctgttctggg acgatggaga gagcctggaa gtgctggagc gaggggccta cacacaggtc   2460

atcttcctgg ccaggaataa cacgatcgtg aatgagctgg tacgtgtgac cagtgaggga   2520

gctggcctgc agctgcagaa ggtgactgtc ctgggcgtgg ccacggcgcc ccagcaggtc   2580

ctctccaacg gtgtccctgt ctccaacttc acctacagcc ccgacaccaa ggtcctggac   2640

atctgtgtct cgctgttgat gggagagcag tttctcgtca gctggtgtta g            2691


<210>  46
<211>  2691
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco1-delta-47

<400>  46
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccctaga     60

gctgtgccta cccagtgtga cgtgcccccc aacagcagat tcgactgcgc ccctgacaag    120

gccatcaccc aggaacagtg cgaggccaga ggctgctgct acatccctgc caagcaggga    180

ctgcagggcg ctcagatggg acagccctgg tgcttcttcc caccctccta ccccagctac    240

aagctggaaa acctgagcag cagcgagatg ggctacaccg ccaccctgac cagaaccacc    300

cccacattct tcccaaagga catcctgacc ctgcggctgg acgtgatgat ggaaaccgag    360

aaccggctgc acttcaccat caaggacccc gccaatcgga gatacgaggt gcccctggaa    420

accccccacg tgcactctag agcccccagc cctctgtaca gcgtggaatt cagcgaggaa    480

cccttcggcg tgatcgtgcg gagacagctg gatggcagag tgctgctgaa caccaccgtg    540

gcccctctgt tcttcgccga ccagttcctg cagctgagca ccagcctgcc cagccagtac    600

atcacaggac tggccgagca cctgagcccc ctgatgctga gcacatcctg gacccggatc    660

accctgtgga acagggatct ggcccctacc cctggcgcca atctgtacgg cagccaccct    720

ttctacctgg ccctggaaga tggcggatct gcccacggag tgtttctgct gaactccaac    780

gccatggacg tggtgctgca gcctagccct gccctgtctt ggagaagcac aggcggcatc    840

ctggatgtgt acatctttct gggccccgag cccaagagcg tggtgcagca gtatctggat    900

gtcgtgggct accccttcat gcccccttac tggggcctgg gattccacct gtgcagatgg    960

ggctactcca gcaccgccat caccagacag gtggtggaaa acatgaccag agcccacttc   1020

ccactggatg tgcagtggaa cgacctggac tacatggaca gcagacggga cttcaccttc   1080

aacaaggacg gcttccggga cttccccgcc atggtgcagg aactgcatca gggcggcaga   1140

cggtacatga tgatcgtgga tcccgccatc agctcctctg gccctgccgg ctcttacaga   1200

ccctacgacg agggcctgcg gagaggcgtg ttcatcacca acgagacagg ccagcccctg   1260

atcggcaaag tgtggcctgg cagcacagcc ttccccgact tcaccaatcc taccgccctg   1320

gcttggtggg aggacatggt ggccgagttc cacgaccagg tgcccttcga cggcatgtgg   1380

atcgacatga acgagcccag caacttcatc cggggcagcg aggatggctg ccccaacaac   1440

gaactggaaa atccccctta cgtgcccggc gtcgtgggcg gaacactgca ggccgctaca   1500

atctgtgcca gcagccacca gtttctgagc acccactaca acctgcacaa cctgtacggc   1560

ctgaccgagg ccattgccag ccaccgcgct ctcgtgaaag ccagaggcac acggcccttc   1620

gtgatcagca gaagcacctt tgccggccac ggcagatacg ccggacattg gactggcgac   1680

gtgtggtcct cttgggagca gctggcctct agcgtgcccg agatcctgca gttcaatctg   1740

ctgggcgtgc cactcgtggg cgccgatgtg tgtggcttcc tgggcaacac ctccgaggaa   1800

ctgtgtgtgc ggtggacaca gctgggcgcc ttctaccctt tcatgagaaa ccacaacagc   1860

ctgctgagcc tgccccagga accctacagc tttagcgagc ctgcacagca ggccatgcgg   1920

aaggccctga cactgagata cgctctgctg ccccacctgt acaccctgtt tcaccaggcc   1980

catgtggccg gcgagacagt ggccagacct ctgtttctgg aattccccaa ggacagcagc   2040

acctggaccg tggaccatca gctgctgtgg ggagaggctc tgctgattac cccagtgctg   2100

caggcaggca aggccgaagt gaccggctac tttcccctgg gcacttggta cgacctgcag   2160

accgtgcctg tggaagccct gggatctctg cctccacctc ctgccgctcc tagagagcct   2220

gccattcact ctgagggcca gtgggtcaca ctgcctgccc ccctggatac catcaacgtg   2280

cacctgaggg ccggctacat cataccactg cagggacctg gcctgaccac caccgagtct   2340

agacagcagc caatggccct ggccgtggcc ctgaccaaag gcggagaagc taggggcgag   2400

ctgttctggg acgatggcga gagcctggaa gtgctggaaa gaggcgccta tacccaagtg   2460

atcttcctgg cccggaacaa caccatcgtg aacgagctgg tgcgcgtgac ctctgaaggc   2520

gctggactgc agctgcagaa agtgaccgtg ctgggagtgg ccacagcccc tcagcaggtg   2580

ctgtctaatg gcgtgcccgt gtccaacttc acctacagcc ccgacaccaa ggtgctggac   2640

atctgcgtgt cactgctgat gggagagcag tttctggtgt cctggtgctg a            2691


<210>  47
<211>  2691
<212>  DNA
<213>  artificial

<220>
<223>  sp7+hGAAco2-delta-47

<400>  47
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcccaaga     60

gctgtgccta cccaatgcga cgtgccaccc aactcccgat tcgactgcgc gccagataag    120

gctattaccc aagagcagtg tgaagccaga ggttgctgct acatcccagc gaagcaagga    180

ttgcaaggcg cccaaatggg acaaccttgg tgtttcttcc ccccttcgta cccatcatat    240

aaactcgaaa acctgtcctc ttcggaaatg ggttatactg ccaccctcac cagaactact    300

cctactttct tcccgaaaga catcttgacc ttgaggctgg acgtgatgat ggagactgaa    360

aaccggctgc atttcactat caaagatcct gccaatcggc gatacgaggt ccctctggaa    420

acccctcacg tgcactcacg ggctccttct ccgctttact ccgtcgaatt ctctgaggaa    480

cccttcggag tgatcgttag acgccagctg gatggtagag tgctgttgaa cactactgtg    540

gccccacttt tcttcgctga ccagtttctg caactgtcca cttccctgcc atcccagtac    600

attactggac tcgccgaaca cctgtcgcca ctgatgctct cgacctcttg gactagaatc    660

actttgtgga acagagactt ggcccctact ccgggagcaa atctgtacgg aagccaccct    720

ttttacctgg cgctcgaaga tggcggatcc gctcacggag tgttcctgct gaatagcaac    780

gcaatggacg tggtgctgca accttcccct gcactcagtt ggagaagtac cgggggtatt    840

ctggacgtgt acatcttcct cggaccagaa cccaagagcg tggtgcagca atatctggac    900

gtggtcggat acccttttat gcctccttac tggggactgg gattccacct ttgccgttgg    960

ggctactcat ccaccgccat taccagacag gtggtggaga atatgaccag agcccacttc   1020

cctctcgacg tgcagtggaa cgatctggac tatatggact cccggagaga tttcaccttc   1080

aacaaggacg ggttccgcga ttttcccgcg atggttcaag agctccacca gggtggtcga   1140

agatatatga tgatcgtcga cccagccatt tcgagcagcg gacccgctgg atcttataga   1200

ccttacgacg aaggccttag gagaggagtg ttcatcacaa acgagactgg acagcctttg   1260

atcggtaaag tgtggcctgg atcaaccgcc tttcctgact ttaccaatcc cactgccttg   1320

gcttggtggg aggacatggt ggccgaattc cacgaccaag tcccctttga tggaatgtgg   1380

atcgatatga acgaaccaag caattttatc agaggttccg aagacggttg ccccaacaac   1440

gaactggaaa accctcctta tgtgcccgga gtcgtgggcg gaacattaca ggccgcgact   1500

atttgcgcca gcagccacca attcctgtcc actcactaca acctccacaa cctttatgga   1560

ttaaccgaag ctattgcaag tcacagggct ctggtgaagg ctagagggac taggcccttt   1620

gtgatctccc gatccacctt tgccggacac gggagatacg ccggtcactg gactggtgac   1680

gtgtggagct catgggaaca actggcctcc tccgtgccgg aaatcttaca gttcaacctt   1740

ctgggtgtcc ctcttgtcgg agcagacgtg tgtgggtttc ttggtaacac ctccgaggaa   1800

ctgtgtgtgc gctggactca actgggtgca ttctacccat tcatgagaaa ccacaactcc   1860

ttgctgtccc tgccacaaga gccctactcg ttcagcgagc ctgcacaaca ggctatgcgg   1920

aaggcactga ccctgagata cgccctgctt ccacacttat acactctctt ccatcaagcg   1980

catgtggcag gagaaaccgt tgcaaggcct cttttccttg aattccccaa ggattcctcg   2040

acttggacgg tggatcatca gctgctgtgg ggagaagctc tgctgattac tccagtgttg   2100

caagccggaa aagctgaggt gaccggatac tttccgctgg gaacctggta cgacctccag   2160

actgtccctg ttgaagccct tggatcactg cctccgcctc cggcagctcc acgcgaacca   2220

gctatacatt ccgagggaca gtgggttaca ttaccagctc ctctggacac aatcaacgtc   2280

cacttaagag ctggctacat tatccctctg caaggaccag gactgactac gaccgagagc   2340

agacagcagc caatggcact ggctgtggct ctgaccaagg gaggggaagc tagaggagaa   2400

ctcttctggg atgatgggga gtcccttgaa gtgctggaaa gaggcgctta cactcaagtc   2460

attttccttg cacggaacaa caccattgtg aacgaattgg tgcgagtgac cagcgaagga   2520

gctggacttc aactgcagaa ggtcactgtg ctcggagtgg ctaccgctcc tcagcaagtg   2580

ctgtcgaatg gagtccccgt gtcaaacttt acctactccc ctgacactaa ggtgctcgac   2640

atttgcgtgt ccctcctgat gggagagcag ttccttgtgt cctggtgttg a            2691


<210>  48
<211>  2652
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1-delta-42

<400>  48
gcccaccccg gcagacctag agctgtgcct acccagtgtg acgtgccccc caacagcaga     60

ttcgactgcg cccctgacaa ggccatcacc caggaacagt gcgaggccag aggctgctgc    120

tacatccctg ccaagcaggg actgcagggc gctcagatgg gacagccctg gtgcttcttc    180

ccaccctcct accccagcta caagctggaa aacctgagca gcagcgagat gggctacacc    240

gccaccctga ccagaaccac ccccacattc ttcccaaagg acatcctgac cctgcggctg    300

gacgtgatga tggaaaccga gaaccggctg cacttcacca tcaaggaccc cgccaatcgg    360

agatacgagg tgcccctgga aaccccccac gtgcactcta gagcccccag ccctctgtac    420

agcgtggaat tcagcgagga acccttcggc gtgatcgtgc ggagacagct ggatggcaga    480

gtgctgctga acaccaccgt ggcccctctg ttcttcgccg accagttcct gcagctgagc    540

accagcctgc ccagccagta catcacagga ctggccgagc acctgagccc cctgatgctg    600

agcacatcct ggacccggat caccctgtgg aacagggatc tggcccctac ccctggcgcc    660

aatctgtacg gcagccaccc tttctacctg gccctggaag atggcggatc tgcccacgga    720

gtgtttctgc tgaactccaa cgccatggac gtggtgctgc agcctagccc tgccctgtct    780

tggagaagca caggcggcat cctggatgtg tacatctttc tgggccccga gcccaagagc    840

gtggtgcagc agtatctgga tgtcgtgggc taccccttca tgccccctta ctggggcctg    900

ggattccacc tgtgcagatg gggctactcc agcaccgcca tcaccagaca ggtggtggaa    960

aacatgacca gagcccactt cccactggat gtgcagtgga acgacctgga ctacatggac   1020

agcagacggg acttcacctt caacaaggac ggcttccggg acttccccgc catggtgcag   1080

gaactgcatc agggcggcag acggtacatg atgatcgtgg atcccgccat cagctcctct   1140

ggccctgccg gctcttacag accctacgac gagggcctgc ggagaggcgt gttcatcacc   1200

aacgagacag gccagcccct gatcggcaaa gtgtggcctg gcagcacagc cttccccgac   1260

ttcaccaatc ctaccgccct ggcttggtgg gaggacatgg tggccgagtt ccacgaccag   1320

gtgcccttcg acggcatgtg gatcgacatg aacgagccca gcaacttcat ccggggcagc   1380

gaggatggct gccccaacaa cgaactggaa aatccccctt acgtgcccgg cgtcgtgggc   1440

ggaacactgc aggccgctac aatctgtgcc agcagccacc agtttctgag cacccactac   1500

aacctgcaca acctgtacgg cctgaccgag gccattgcca gccaccgcgc tctcgtgaaa   1560

gccagaggca cacggccctt cgtgatcagc agaagcacct ttgccggcca cggcagatac   1620

gccggacatt ggactggcga cgtgtggtcc tcttgggagc agctggcctc tagcgtgccc   1680

gagatcctgc agttcaatct gctgggcgtg ccactcgtgg gcgccgatgt gtgtggcttc   1740

ctgggcaaca cctccgagga actgtgtgtg cggtggacac agctgggcgc cttctaccct   1800

ttcatgagaa accacaacag cctgctgagc ctgccccagg aaccctacag ctttagcgag   1860

cctgcacagc aggccatgcg gaaggccctg acactgagat acgctctgct gccccacctg   1920

tacaccctgt ttcaccaggc ccatgtggcc ggcgagacag tggccagacc tctgtttctg   1980

gaattcccca aggacagcag cacctggacc gtggaccatc agctgctgtg gggagaggct   2040

ctgctgatta ccccagtgct gcaggcaggc aaggccgaag tgaccggcta ctttcccctg   2100

ggcacttggt acgacctgca gaccgtgcct gtggaagccc tgggatctct gcctccacct   2160

cctgccgctc ctagagagcc tgccattcac tctgagggcc agtgggtcac actgcctgcc   2220

cccctggata ccatcaacgt gcacctgagg gccggctaca tcataccact gcagggacct   2280

ggcctgacca ccaccgagtc tagacagcag ccaatggccc tggccgtggc cctgaccaaa   2340

ggcggagaag ctaggggcga gctgttctgg gacgatggcg agagcctgga agtgctggaa   2400

agaggcgcct atacccaagt gatcttcctg gcccggaaca acaccatcgt gaacgagctg   2460

gtgcgcgtga cctctgaagg cgctggactg cagctgcaga aagtgaccgt gctgggagtg   2520

gccacagccc ctcagcaggt gctgtctaat ggcgtgcccg tgtccaactt cacctacagc   2580

cccgacacca aggtgctgga catctgcgtg tcactgctga tgggagagca gtttctggtg   2640

tcctggtgct ga                                                       2652


<210>  49
<211>  2652
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2-delta-42

<400>  49
gcccatcctg gtagaccaag agctgtgcct acccaatgcg acgtgccacc caactcccga     60

ttcgactgcg cgccagataa ggctattacc caagagcagt gtgaagccag aggttgctgc    120

tacatcccag cgaagcaagg attgcaaggc gcccaaatgg gacaaccttg gtgtttcttc    180

cccccttcgt acccatcata taaactcgaa aacctgtcct cttcggaaat gggttatact    240

gccaccctca ccagaactac tcctactttc ttcccgaaag acatcttgac cttgaggctg    300

gacgtgatga tggagactga aaaccggctg catttcacta tcaaagatcc tgccaatcgg    360

cgatacgagg tccctctgga aacccctcac gtgcactcac gggctccttc tccgctttac    420

tccgtcgaat tctctgagga acccttcgga gtgatcgtta gacgccagct ggatggtaga    480

gtgctgttga acactactgt ggccccactt ttcttcgctg accagtttct gcaactgtcc    540

acttccctgc catcccagta cattactgga ctcgccgaac acctgtcgcc actgatgctc    600

tcgacctctt ggactagaat cactttgtgg aacagagact tggcccctac tccgggagca    660

aatctgtacg gaagccaccc tttttacctg gcgctcgaag atggcggatc cgctcacgga    720

gtgttcctgc tgaatagcaa cgcaatggac gtggtgctgc aaccttcccc tgcactcagt    780

tggagaagta ccgggggtat tctggacgtg tacatcttcc tcggaccaga acccaagagc    840

gtggtgcagc aatatctgga cgtggtcgga taccctttta tgcctcctta ctggggactg    900

ggattccacc tttgccgttg gggctactca tccaccgcca ttaccagaca ggtggtggag    960

aatatgacca gagcccactt ccctctcgac gtgcagtgga acgatctgga ctatatggac   1020

tcccggagag atttcacctt caacaaggac gggttccgcg attttcccgc gatggttcaa   1080

gagctccacc agggtggtcg aagatatatg atgatcgtcg acccagccat ttcgagcagc   1140

ggacccgctg gatcttatag accttacgac gaaggcctta ggagaggagt gttcatcaca   1200

aacgagactg gacagccttt gatcggtaaa gtgtggcctg gatcaaccgc ctttcctgac   1260

tttaccaatc ccactgcctt ggcttggtgg gaggacatgg tggccgaatt ccacgaccaa   1320

gtcccctttg atggaatgtg gatcgatatg aacgaaccaa gcaattttat cagaggttcc   1380

gaagacggtt gccccaacaa cgaactggaa aaccctcctt atgtgcccgg agtcgtgggc   1440

ggaacattac aggccgcgac tatttgcgcc agcagccacc aattcctgtc cactcactac   1500

aacctccaca acctttatgg attaaccgaa gctattgcaa gtcacagggc tctggtgaag   1560

gctagaggga ctaggccctt tgtgatctcc cgatccacct ttgccggaca cgggagatac   1620

gccggtcact ggactggtga cgtgtggagc tcatgggaac aactggcctc ctccgtgccg   1680

gaaatcttac agttcaacct tctgggtgtc cctcttgtcg gagcagacgt gtgtgggttt   1740

cttggtaaca cctccgagga actgtgtgtg cgctggactc aactgggtgc attctaccca   1800

ttcatgagaa accacaactc cttgctgtcc ctgccacaag agccctactc gttcagcgag   1860

cctgcacaac aggctatgcg gaaggcactg accctgagat acgccctgct tccacactta   1920

tacactctct tccatcaagc gcatgtggca ggagaaaccg ttgcaaggcc tcttttcctt   1980

gaattcccca aggattcctc gacttggacg gtggatcatc agctgctgtg gggagaagct   2040

ctgctgatta ctccagtgtt gcaagccgga aaagctgagg tgaccggata ctttccgctg   2100

ggaacctggt acgacctcca gactgtccct gttgaagccc ttggatcact gcctccgcct   2160

ccggcagctc cacgcgaacc agctatacat tccgagggac agtgggttac attaccagct   2220

cctctggaca caatcaacgt ccacttaaga gctggctaca ttatccctct gcaaggacca   2280

ggactgacta cgaccgagag cagacagcag ccaatggcac tggctgtggc tctgaccaag   2340

ggaggggaag ctagaggaga actcttctgg gatgatgggg agtcccttga agtgctggaa   2400

agaggcgctt acactcaagt cattttcctt gcacggaaca acaccattgt gaacgaattg   2460

gtgcgagtga ccagcgaagg agctggactt caactgcaga aggtcactgt gctcggagtg   2520

gctaccgctc ctcagcaagt gctgtcgaat ggagtccccg tgtcaaactt tacctactcc   2580

cctgacacta aggtgctcga catttgcgtg tccctcctga tgggagagca gttccttgtg   2640

tcctggtgtt ga                                                       2652


<210>  50
<211>  2649
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1-delta-43

<400>  50
caccccggca gacctagagc tgtgcctacc cagtgtgacg tgccccccaa cagcagattc     60

gactgcgccc ctgacaaggc catcacccag gaacagtgcg aggccagagg ctgctgctac    120

atccctgcca agcagggact gcagggcgct cagatgggac agccctggtg cttcttccca    180

ccctcctacc ccagctacaa gctggaaaac ctgagcagca gcgagatggg ctacaccgcc    240

accctgacca gaaccacccc cacattcttc ccaaaggaca tcctgaccct gcggctggac    300

gtgatgatgg aaaccgagaa ccggctgcac ttcaccatca aggaccccgc caatcggaga    360

tacgaggtgc ccctggaaac cccccacgtg cactctagag cccccagccc tctgtacagc    420

gtggaattca gcgaggaacc cttcggcgtg atcgtgcgga gacagctgga tggcagagtg    480

ctgctgaaca ccaccgtggc ccctctgttc ttcgccgacc agttcctgca gctgagcacc    540

agcctgccca gccagtacat cacaggactg gccgagcacc tgagccccct gatgctgagc    600

acatcctgga cccggatcac cctgtggaac agggatctgg cccctacccc tggcgccaat    660

ctgtacggca gccacccttt ctacctggcc ctggaagatg gcggatctgc ccacggagtg    720

tttctgctga actccaacgc catggacgtg gtgctgcagc ctagccctgc cctgtcttgg    780

agaagcacag gcggcatcct ggatgtgtac atctttctgg gccccgagcc caagagcgtg    840

gtgcagcagt atctggatgt cgtgggctac cccttcatgc ccccttactg gggcctggga    900

ttccacctgt gcagatgggg ctactccagc accgccatca ccagacaggt ggtggaaaac    960

atgaccagag cccacttccc actggatgtg cagtggaacg acctggacta catggacagc   1020

agacgggact tcaccttcaa caaggacggc ttccgggact tccccgccat ggtgcaggaa   1080

ctgcatcagg gcggcagacg gtacatgatg atcgtggatc ccgccatcag ctcctctggc   1140

cctgccggct cttacagacc ctacgacgag ggcctgcgga gaggcgtgtt catcaccaac   1200

gagacaggcc agcccctgat cggcaaagtg tggcctggca gcacagcctt ccccgacttc   1260

accaatccta ccgccctggc ttggtgggag gacatggtgg ccgagttcca cgaccaggtg   1320

cccttcgacg gcatgtggat cgacatgaac gagcccagca acttcatccg gggcagcgag   1380

gatggctgcc ccaacaacga actggaaaat cccccttacg tgcccggcgt cgtgggcgga   1440

acactgcagg ccgctacaat ctgtgccagc agccaccagt ttctgagcac ccactacaac   1500

ctgcacaacc tgtacggcct gaccgaggcc attgccagcc accgcgctct cgtgaaagcc   1560

agaggcacac ggcccttcgt gatcagcaga agcacctttg ccggccacgg cagatacgcc   1620

ggacattgga ctggcgacgt gtggtcctct tgggagcagc tggcctctag cgtgcccgag   1680

atcctgcagt tcaatctgct gggcgtgcca ctcgtgggcg ccgatgtgtg tggcttcctg   1740

ggcaacacct ccgaggaact gtgtgtgcgg tggacacagc tgggcgcctt ctaccctttc   1800

atgagaaacc acaacagcct gctgagcctg ccccaggaac cctacagctt tagcgagcct   1860

gcacagcagg ccatgcggaa ggccctgaca ctgagatacg ctctgctgcc ccacctgtac   1920

accctgtttc accaggccca tgtggccggc gagacagtgg ccagacctct gtttctggaa   1980

ttccccaagg acagcagcac ctggaccgtg gaccatcagc tgctgtgggg agaggctctg   2040

ctgattaccc cagtgctgca ggcaggcaag gccgaagtga ccggctactt tcccctgggc   2100

acttggtacg acctgcagac cgtgcctgtg gaagccctgg gatctctgcc tccacctcct   2160

gccgctccta gagagcctgc cattcactct gagggccagt gggtcacact gcctgccccc   2220

ctggatacca tcaacgtgca cctgagggcc ggctacatca taccactgca gggacctggc   2280

ctgaccacca ccgagtctag acagcagcca atggccctgg ccgtggccct gaccaaaggc   2340

ggagaagcta ggggcgagct gttctgggac gatggcgaga gcctggaagt gctggaaaga   2400

ggcgcctata cccaagtgat cttcctggcc cggaacaaca ccatcgtgaa cgagctggtg   2460

cgcgtgacct ctgaaggcgc tggactgcag ctgcagaaag tgaccgtgct gggagtggcc   2520

acagcccctc agcaggtgct gtctaatggc gtgcccgtgt ccaacttcac ctacagcccc   2580

gacaccaagg tgctggacat ctgcgtgtca ctgctgatgg gagagcagtt tctggtgtcc   2640

tggtgctga                                                           2649


<210>  51
<211>  2649
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2-delta-43

<400>  51
catcctggta gaccaagagc tgtgcctacc caatgcgacg tgccacccaa ctcccgattc     60

gactgcgcgc cagataaggc tattacccaa gagcagtgtg aagccagagg ttgctgctac    120

atcccagcga agcaaggatt gcaaggcgcc caaatgggac aaccttggtg tttcttcccc    180

ccttcgtacc catcatataa actcgaaaac ctgtcctctt cggaaatggg ttatactgcc    240

accctcacca gaactactcc tactttcttc ccgaaagaca tcttgacctt gaggctggac    300

gtgatgatgg agactgaaaa ccggctgcat ttcactatca aagatcctgc caatcggcga    360

tacgaggtcc ctctggaaac ccctcacgtg cactcacggg ctccttctcc gctttactcc    420

gtcgaattct ctgaggaacc cttcggagtg atcgttagac gccagctgga tggtagagtg    480

ctgttgaaca ctactgtggc cccacttttc ttcgctgacc agtttctgca actgtccact    540

tccctgccat cccagtacat tactggactc gccgaacacc tgtcgccact gatgctctcg    600

acctcttgga ctagaatcac tttgtggaac agagacttgg cccctactcc gggagcaaat    660

ctgtacggaa gccacccttt ttacctggcg ctcgaagatg gcggatccgc tcacggagtg    720

ttcctgctga atagcaacgc aatggacgtg gtgctgcaac cttcccctgc actcagttgg    780

agaagtaccg ggggtattct ggacgtgtac atcttcctcg gaccagaacc caagagcgtg    840

gtgcagcaat atctggacgt ggtcggatac ccttttatgc ctccttactg gggactggga    900

ttccaccttt gccgttgggg ctactcatcc accgccatta ccagacaggt ggtggagaat    960

atgaccagag cccacttccc tctcgacgtg cagtggaacg atctggacta tatggactcc   1020

cggagagatt tcaccttcaa caaggacggg ttccgcgatt ttcccgcgat ggttcaagag   1080

ctccaccagg gtggtcgaag atatatgatg atcgtcgacc cagccatttc gagcagcgga   1140

cccgctggat cttatagacc ttacgacgaa ggccttagga gaggagtgtt catcacaaac   1200

gagactggac agcctttgat cggtaaagtg tggcctggat caaccgcctt tcctgacttt   1260

accaatccca ctgccttggc ttggtgggag gacatggtgg ccgaattcca cgaccaagtc   1320

ccctttgatg gaatgtggat cgatatgaac gaaccaagca attttatcag aggttccgaa   1380

gacggttgcc ccaacaacga actggaaaac cctccttatg tgcccggagt cgtgggcgga   1440

acattacagg ccgcgactat ttgcgccagc agccaccaat tcctgtccac tcactacaac   1500

ctccacaacc tttatggatt aaccgaagct attgcaagtc acagggctct ggtgaaggct   1560

agagggacta ggccctttgt gatctcccga tccacctttg ccggacacgg gagatacgcc   1620

ggtcactgga ctggtgacgt gtggagctca tgggaacaac tggcctcctc cgtgccggaa   1680

atcttacagt tcaaccttct gggtgtccct cttgtcggag cagacgtgtg tgggtttctt   1740

ggtaacacct ccgaggaact gtgtgtgcgc tggactcaac tgggtgcatt ctacccattc   1800

atgagaaacc acaactcctt gctgtccctg ccacaagagc cctactcgtt cagcgagcct   1860

gcacaacagg ctatgcggaa ggcactgacc ctgagatacg ccctgcttcc acacttatac   1920

actctcttcc atcaagcgca tgtggcagga gaaaccgttg caaggcctct tttccttgaa   1980

ttccccaagg attcctcgac ttggacggtg gatcatcagc tgctgtgggg agaagctctg   2040

ctgattactc cagtgttgca agccggaaaa gctgaggtga ccggatactt tccgctggga   2100

acctggtacg acctccagac tgtccctgtt gaagcccttg gatcactgcc tccgcctccg   2160

gcagctccac gcgaaccagc tatacattcc gagggacagt gggttacatt accagctcct   2220

ctggacacaa tcaacgtcca cttaagagct ggctacatta tccctctgca aggaccagga   2280

ctgactacga ccgagagcag acagcagcca atggcactgg ctgtggctct gaccaaggga   2340

ggggaagcta gaggagaact cttctgggat gatggggagt cccttgaagt gctggaaaga   2400

ggcgcttaca ctcaagtcat tttccttgca cggaacaaca ccattgtgaa cgaattggtg   2460

cgagtgacca gcgaaggagc tggacttcaa ctgcagaagg tcactgtgct cggagtggct   2520

accgctcctc agcaagtgct gtcgaatgga gtccccgtgt caaactttac ctactcccct   2580

gacactaagg tgctcgacat ttgcgtgtcc ctcctgatgg gagagcagtt ccttgtgtcc   2640

tggtgttga                                                           2649


<210>  52
<211>  2637
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1-delta-47

<400>  52
cctagagctg tgcctaccca gtgtgacgtg ccccccaaca gcagattcga ctgcgcccct     60

gacaaggcca tcacccagga acagtgcgag gccagaggct gctgctacat ccctgccaag    120

cagggactgc agggcgctca gatgggacag ccctggtgct tcttcccacc ctcctacccc    180

agctacaagc tggaaaacct gagcagcagc gagatgggct acaccgccac cctgaccaga    240

accaccccca cattcttccc aaaggacatc ctgaccctgc ggctggacgt gatgatggaa    300

accgagaacc ggctgcactt caccatcaag gaccccgcca atcggagata cgaggtgccc    360

ctggaaaccc cccacgtgca ctctagagcc cccagccctc tgtacagcgt ggaattcagc    420

gaggaaccct tcggcgtgat cgtgcggaga cagctggatg gcagagtgct gctgaacacc    480

accgtggccc ctctgttctt cgccgaccag ttcctgcagc tgagcaccag cctgcccagc    540

cagtacatca caggactggc cgagcacctg agccccctga tgctgagcac atcctggacc    600

cggatcaccc tgtggaacag ggatctggcc cctacccctg gcgccaatct gtacggcagc    660

caccctttct acctggccct ggaagatggc ggatctgccc acggagtgtt tctgctgaac    720

tccaacgcca tggacgtggt gctgcagcct agccctgccc tgtcttggag aagcacaggc    780

ggcatcctgg atgtgtacat ctttctgggc cccgagccca agagcgtggt gcagcagtat    840

ctggatgtcg tgggctaccc cttcatgccc ccttactggg gcctgggatt ccacctgtgc    900

agatggggct actccagcac cgccatcacc agacaggtgg tggaaaacat gaccagagcc    960

cacttcccac tggatgtgca gtggaacgac ctggactaca tggacagcag acgggacttc   1020

accttcaaca aggacggctt ccgggacttc cccgccatgg tgcaggaact gcatcagggc   1080

ggcagacggt acatgatgat cgtggatccc gccatcagct cctctggccc tgccggctct   1140

tacagaccct acgacgaggg cctgcggaga ggcgtgttca tcaccaacga gacaggccag   1200

cccctgatcg gcaaagtgtg gcctggcagc acagccttcc ccgacttcac caatcctacc   1260

gccctggctt ggtgggagga catggtggcc gagttccacg accaggtgcc cttcgacggc   1320

atgtggatcg acatgaacga gcccagcaac ttcatccggg gcagcgagga tggctgcccc   1380

aacaacgaac tggaaaatcc cccttacgtg cccggcgtcg tgggcggaac actgcaggcc   1440

gctacaatct gtgccagcag ccaccagttt ctgagcaccc actacaacct gcacaacctg   1500

tacggcctga ccgaggccat tgccagccac cgcgctctcg tgaaagccag aggcacacgg   1560

cccttcgtga tcagcagaag cacctttgcc ggccacggca gatacgccgg acattggact   1620

ggcgacgtgt ggtcctcttg ggagcagctg gcctctagcg tgcccgagat cctgcagttc   1680

aatctgctgg gcgtgccact cgtgggcgcc gatgtgtgtg gcttcctggg caacacctcc   1740

gaggaactgt gtgtgcggtg gacacagctg ggcgccttct accctttcat gagaaaccac   1800

aacagcctgc tgagcctgcc ccaggaaccc tacagcttta gcgagcctgc acagcaggcc   1860

atgcggaagg ccctgacact gagatacgct ctgctgcccc acctgtacac cctgtttcac   1920

caggcccatg tggccggcga gacagtggcc agacctctgt ttctggaatt ccccaaggac   1980

agcagcacct ggaccgtgga ccatcagctg ctgtggggag aggctctgct gattacccca   2040

gtgctgcagg caggcaaggc cgaagtgacc ggctactttc ccctgggcac ttggtacgac   2100

ctgcagaccg tgcctgtgga agccctggga tctctgcctc cacctcctgc cgctcctaga   2160

gagcctgcca ttcactctga gggccagtgg gtcacactgc ctgcccccct ggataccatc   2220

aacgtgcacc tgagggccgg ctacatcata ccactgcagg gacctggcct gaccaccacc   2280

gagtctagac agcagccaat ggccctggcc gtggccctga ccaaaggcgg agaagctagg   2340

ggcgagctgt tctgggacga tggcgagagc ctggaagtgc tggaaagagg cgcctatacc   2400

caagtgatct tcctggcccg gaacaacacc atcgtgaacg agctggtgcg cgtgacctct   2460

gaaggcgctg gactgcagct gcagaaagtg accgtgctgg gagtggccac agcccctcag   2520

caggtgctgt ctaatggcgt gcccgtgtcc aacttcacct acagccccga caccaaggtg   2580

ctggacatct gcgtgtcact gctgatggga gagcagtttc tggtgtcctg gtgctga      2637


<210>  53
<211>  2637
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2-delta-47

<400>  53
ccaagagctg tgcctaccca atgcgacgtg ccacccaact cccgattcga ctgcgcgcca     60

gataaggcta ttacccaaga gcagtgtgaa gccagaggtt gctgctacat cccagcgaag    120

caaggattgc aaggcgccca aatgggacaa ccttggtgtt tcttcccccc ttcgtaccca    180

tcatataaac tcgaaaacct gtcctcttcg gaaatgggtt atactgccac cctcaccaga    240

actactccta ctttcttccc gaaagacatc ttgaccttga ggctggacgt gatgatggag    300

actgaaaacc ggctgcattt cactatcaaa gatcctgcca atcggcgata cgaggtccct    360

ctggaaaccc ctcacgtgca ctcacgggct ccttctccgc tttactccgt cgaattctct    420

gaggaaccct tcggagtgat cgttagacgc cagctggatg gtagagtgct gttgaacact    480

actgtggccc cacttttctt cgctgaccag tttctgcaac tgtccacttc cctgccatcc    540

cagtacatta ctggactcgc cgaacacctg tcgccactga tgctctcgac ctcttggact    600

agaatcactt tgtggaacag agacttggcc cctactccgg gagcaaatct gtacggaagc    660

cacccttttt acctggcgct cgaagatggc ggatccgctc acggagtgtt cctgctgaat    720

agcaacgcaa tggacgtggt gctgcaacct tcccctgcac tcagttggag aagtaccggg    780

ggtattctgg acgtgtacat cttcctcgga ccagaaccca agagcgtggt gcagcaatat    840

ctggacgtgg tcggataccc ttttatgcct ccttactggg gactgggatt ccacctttgc    900

cgttggggct actcatccac cgccattacc agacaggtgg tggagaatat gaccagagcc    960

cacttccctc tcgacgtgca gtggaacgat ctggactata tggactcccg gagagatttc   1020

accttcaaca aggacgggtt ccgcgatttt cccgcgatgg ttcaagagct ccaccagggt   1080

ggtcgaagat atatgatgat cgtcgaccca gccatttcga gcagcggacc cgctggatct   1140

tatagacctt acgacgaagg ccttaggaga ggagtgttca tcacaaacga gactggacag   1200

cctttgatcg gtaaagtgtg gcctggatca accgcctttc ctgactttac caatcccact   1260

gccttggctt ggtgggagga catggtggcc gaattccacg accaagtccc ctttgatgga   1320

atgtggatcg atatgaacga accaagcaat tttatcagag gttccgaaga cggttgcccc   1380

aacaacgaac tggaaaaccc tccttatgtg cccggagtcg tgggcggaac attacaggcc   1440

gcgactattt gcgccagcag ccaccaattc ctgtccactc actacaacct ccacaacctt   1500

tatggattaa ccgaagctat tgcaagtcac agggctctgg tgaaggctag agggactagg   1560

ccctttgtga tctcccgatc cacctttgcc ggacacggga gatacgccgg tcactggact   1620

ggtgacgtgt ggagctcatg ggaacaactg gcctcctccg tgccggaaat cttacagttc   1680

aaccttctgg gtgtccctct tgtcggagca gacgtgtgtg ggtttcttgg taacacctcc   1740

gaggaactgt gtgtgcgctg gactcaactg ggtgcattct acccattcat gagaaaccac   1800

aactccttgc tgtccctgcc acaagagccc tactcgttca gcgagcctgc acaacaggct   1860

atgcggaagg cactgaccct gagatacgcc ctgcttccac acttatacac tctcttccat   1920

caagcgcatg tggcaggaga aaccgttgca aggcctcttt tccttgaatt ccccaaggat   1980

tcctcgactt ggacggtgga tcatcagctg ctgtggggag aagctctgct gattactcca   2040

gtgttgcaag ccggaaaagc tgaggtgacc ggatactttc cgctgggaac ctggtacgac   2100

ctccagactg tccctgttga agcccttgga tcactgcctc cgcctccggc agctccacgc   2160

gaaccagcta tacattccga gggacagtgg gttacattac cagctcctct ggacacaatc   2220

aacgtccact taagagctgg ctacattatc cctctgcaag gaccaggact gactacgacc   2280

gagagcagac agcagccaat ggcactggct gtggctctga ccaagggagg ggaagctaga   2340

ggagaactct tctgggatga tggggagtcc cttgaagtgc tggaaagagg cgcttacact   2400

caagtcattt tccttgcacg gaacaacacc attgtgaacg aattggtgcg agtgaccagc   2460

gaaggagctg gacttcaact gcagaaggtc actgtgctcg gagtggctac cgctcctcag   2520

caagtgctgt cgaatggagt ccccgtgtca aactttacct actcccctga cactaaggtg   2580

ctcgacattt gcgtgtccct cctgatggga gagcagttcc ttgtgtcctg gtgttga      2637


