                         SEQUENCE LISTING

<110>  The Provost, Fellows, Foundation Scholars, & the other 
       members of Board, of the College of the Holy & Undiv. Trinity of 
       Queen Elizabeth, near Dublin
 
<120>  Marker and Target as a Diagnostic Variable and Target for Therapy
        of Metastatic Cancer

<130>  P11964PC00

<150>  EP16188421
<151>  2016-09-12

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  4481
<212>  DNA
<213>  Homo sapiens

<400>  1
ttcctgtcta cgtttcattt cctgggggct tgccaagtga taaacagacc caggcgtgtg       60

tggtagagtt cgggtttttt agcacgaagt gggtggctgg agtttgcttg aaaacatcaa      120

ttgactttgt gatcattaca gaaatgctgg tgtaaggtgt tcagaagaca atggagaaaa      180

aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag ggagtttggg      240

aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat gtcaacctga      300

cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag gtcaccaata      360

agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc tatgggagac      420

cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa tggactctgc      480

acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt gttctgtatc      540

cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt acagcagatg      600

aatggaacag caaccatacg atagaaatag agataaatca gactctggaa ataccatgct      660

ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg gtggaaaaca      720

gcagcacgga ttcttgggtc cttctttcta agggtataaa ggaggataat ggaactcagg      780

aaacacttat ctcccaaaat cacctcatca gcaattccac attacttaaa gatagagtca      840

agcttggtac agactacaga ctccacctct ctccagtcca aatcttcgat gatgggcgga      900

agttctcttg ccacattaga gtcggtccta acaaaatctt gaggagctcc accacagtca      960

aggtttttgc taaaccagaa atccctgtga ttgtggaaaa taactccacg gatgtcttgg     1020

tagagagaag atttacctgc ttactaaaga atgtatttcc caaagcaaat atcacatggt     1080

ttatagatgg aagttttctt catgatgaaa aagaaggaat atatattact aatgaagaga     1140

gaaaaggcaa agatggattt ttggaactga agtctgtttt aacaagggta catagtaata     1200

aaccagccca atcagacaac ttgaccattt ggtgtatggc tctgtctcca gtcccaggaa     1260

ataaagtgtg gaacatctca tcagaaaaga tcacttttct cttaggttct gaaatttcct     1320

caacagaccc tccactgagt gttacagaat ctacccttga cacccaacct tctccagcca     1380

gcagtgtatc tcctgcaaga tatccagcta catcttcagt gacccttgta gatgtgagtg     1440

ccttgaggcc aaacaccact cctcaaccca gcaattccag tatgactacc cgaggcttca     1500

actatccctg gacctccagt gggacagata ccaaaaaatc agtttcacgg atacctagtg     1560

aaacatacag ttcatccccg tcaggtgcag gctcaacact tcatgacaat gtctttacca     1620

gcacagccag agcattttca gaagtcccca caactgccaa tggatctacg aaaactaatc     1680

acgtccatat cactggtatt gtggtcaata agcccaaaga tggaatgtcc tggccagtga     1740

ttgtagcagc tttactcttt tgctgcatga tattgtttgg tcttggagtg agaaaatggt     1800

gtcagtacca aaaagaaata atggaaagac ctccaccttt caagccacca ccacctccca     1860

tcaagtacac ttgcattcaa gagcccaacg aaagtgatct gccttatcat gagatggaga     1920

ccctctagtc tcgtgagact ttgccccatg gcagaactct gctggaatcc tattgagaag     1980

gtagacattg tgctttatta atatagtcgc tcttcagcca tgcctttgct gcagctgaaa     2040

tggaagtcag aagtgagtga cctgttttcc cagcaactca ccctcttcca tctccaaacg     2100

cctgaagctt aaccaagagt gagaggatat gtcatgttca cactcaatgc aattcgtagt     2160

ggttttcttg cttatgtaag aagtacatat tagtctgcca tctttaaaaa aaaatacagt     2220

attttcattt aaattctctg atggagggac aacaatggtt tcaactgtat gcccatgcct     2280

gatcctctta tttgaacatc tatcaacatt gtaaactctt tgccaaaatc ctggggcttt     2340

gctgcattcc ctaagataat tacaggaaaa agaaaatgta aaagtgctaa caaggctgcc     2400

aagtaatgga gaagtatggt tagtcttcat attgaaattc tgttgcttat tttcatggaa     2460

ggaaacagaa tactttgcac aggaaccaca ttttcaatcc tccttcactg tcttcctacc     2520

atgttcagcc cagactcctg ccacatggac caggatgaag agggatcaaa gagataatta     2580

gccaaaaacc cagtagccta gaagatacaa aactccactg gcctctaaaa ttatattagc     2640

caagagtggt ttcatttgag tgccttcgtg tgtatgtcca tcaaactgga accaaactgt     2700

tttgtaagta aacaggcagc ctaagcccaa ccctactttc taattccagt tattctcttt     2760

ttcatctggg gatttacctg ttcatttaat ctgcctgttt tgatctgttt tgaaaaagat     2820

aaagagcctc aaatcagacc agcactgatt aattaaccct gctcctacca atctttttta     2880

aagcagttga agcagaatgt ataggtgtca gagaagaaac ctagtcagcc agacgtgctc     2940

tgtattcagc aatagtttgt gaatgaataa attactaatc ctccttgtcg cttgaaacct     3000

tcccacactc cctgctccag gagggaaaaa cagatgttgt tgacagatag agtgataggc     3060

aaattctgtg tggactttag tcccaaaagg aaactttagt tcacttgcag tatgcttatc     3120

cttgactgca catgagaatg ccttgtgcag agttatttgg agattatgtc tttttcttaa     3180

acaccatggc tgtcacactt cagttcaatt aaatcagaat gtctgaggag tgagacacag     3240

gcatcaacac tctcaaatga ttcacatgtt cagccaaagt tgagaaccat cgagcctgtg     3300

gaagttcttt ctcatggctc agaatcttag gtaggtgctt aactcttgtg gtggccagcc     3360

tccaagatga gccccagtgt tcttgcctcc tactattcac atctttatgt ggtcccctcc     3420

aatgctgaat acagatgatt tgtgtaacct gaggccagga ttaaggggag gcaatcaatg     3480

cacctaggga aaaaatttaa ggaggtattc acactcaggg tcatgcactt gcacaatgtt     3540

gagaatgagt accactctca ccattggtat agccaaaaaa gcttggaagt gaccaaggct     3600

aggtcacaaa atacactgtg gcttcttctt tgatctctct ttgaccatac tgacactggg     3660

aaaagcccat tcccatgcca tgaagacacc aaggcagccc tattgagaaa tctacctgtc     3720

gtggccgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg     3780

gatcacgagg tcaggagatc gagaccatcc tggctaacac agtgaaaccc cgtctctact     3840

aaaaatacaa aaaattagcc gggtgtggtg tcgggcacct gtagtcccag ctactcagga     3900

ggctgaggca ggagaagggt gggaacccgg gaggcagagc ttgcagtgag ccgagattgt     3960

gccactgcac actccaatct gggtgaaaga ccgagactcc gcctcaaaaa aaaaaaaaaa     4020

agaaagaaag aaagaaagaa agaaatctac ctgtcaagga actaaggtat tttgctaaca     4080

agcaccaact tgccagccat gtaagggagc catcttggaa gcagatcctc cagcctccag     4140

tcaagtcttc agataattgc aacttcagtt gatcttttga ccaagacctc aagagagcca     4200

gaactaccca gctaagcctt ttactaaatt tctgaacttc taacactatt agataataag     4260

tgcttattgt ttaacaccat taattttgag tataatttgt tacatagcga cagataacta     4320

tacagctcaa caactagaaa aataaactgt ttacctgcct taattattta tctttagttc     4380

cttattagtt ctcaagaaac aaatgctagc ttcatatgta tggctgttgc tttgcttcat     4440

gtgtatggct atttgtattt aacaagactt aatcatcagt a                         4481


<210>  2
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  2
atggagaaaa aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag       60

ggagtttggg aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat      120

gtcaacctga cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag      180

gtcaccaata agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc      240

tatgggagac cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa      300

tggactctgc acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt      360

gttctgtatc cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt      420

acagcagatg aatggaacag caaccatacg atagaaatag agataaatca gactctggaa      480

ataccatgct ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg      540

gtggaaaaca gcagcacgga ttcttgggtc cttctttcta agggtataaa ggaggataat      600

ggaactcagg aaacacttat ctcccaaaat cacctcatca gcaattccac attacttaaa      660

gatagagtca agcttggtac agactacaga ctccacctct ctccagtcca aatcttcgat      720

gatgggcgga agttctcttg ccacattaga gtcggtccta acaaaatctt gaggagctcc      780

accacagtca aggtttttgc taaaccagaa atccctgtga ttgtggaaaa taactccacg      840

gatgtcttgg tagagagaag atttacctgc ttactaaaga atgtatttcc caaagcaaat      900

atcacatggt ttatagatgg aagttttctt catgatgaaa aagaaggaat atatattact      960

aatgaagaga gaaaaggcaa agatggattt ttggaactga agtctgtttt aacaagggta     1020

catagtaata aaccagccca atcagacaac ttgaccattt ggtgtatggc tctgtctcca     1080

gtcccaggaa ataaagtgtg gaacatctca tcagaaaaga tcacttttct cttaggttct     1140

gaaatttcct caacagaccc tccactgagt gttacagaat ctacccttga cacccaacct     1200

tctccagcca gcagtgtatc tcctgcaaga tatccagcta catcttcagt gacccttgta     1260

gatgtgagtg ccttgaggcc aaacaccact cctcaaccca gcaattccag tatgactacc     1320

cgaggcttca actatccctg gacctccagt gggacagata ccaaaaaatc agtttcacgg     1380

atacctagtg aaacatacag ttcatccccg tcaggtgcag gctcaacact tcatgacaat     1440

gtctttacca gcacagccag agcattttca gaagtcccca caactgccaa tggatctacg     1500

aaaactaatc acgtccatat cactggtatt gtggtcaata agcccaaaga tggaatgtcc     1560

tggccagtga ttgtagcagc tttactcttt tgctgcatga tattgtttgg tcttggagtg     1620

agaaaatggt gtcagtacca aaaagaaata atggaaagac ctccaccttt caagccacca     1680

ccacctccca tcaagtacac ttgcattcaa gagcccaacg aaagtgatct gccttatcat     1740

gagatggaga ccctctag                                                   1758


<210>  3
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
        515                 520                 525             


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
    530                 535                 540                 


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
                565                 570                 575     


Leu Pro Tyr His Glu Met Glu Thr Leu 
            580                 585 


<210>  4
<211>  4433
<212>  DNA
<213>  Homo sapiens

<400>  4
ttcctgtcta cgtttcattt cctgggggct tgccaagtga taaacagacc caggcgtgtg       60

tggtagagtt cgggtttttt agcacgaagt gggtggctgg agtttgcttg aaaacatcaa      120

ttgactttgt gatcattaca gaaatgctgg tgtaaggtgt tcagaagaca atggagaaaa      180

aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag ggagtttggg      240

aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat gtcaacctga      300

cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag gtcaccaata      360

agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc tatgggagac      420

cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa tggactctgc      480

acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt gttctgtatc      540

cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt acagcagatg      600

aatggaacag caaccatacg atagaaatag agataaatca gactctggaa ataccatgct      660

ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg gtggaggata      720

atggaactca ggaaacactt atctcccaaa atcacctcat cagcaattcc acattactta      780

aagatagagt caagcttggt acagactaca gactccacct ctctccagtc caaatcttcg      840

atgatgggcg gaagttctct tgccacatta gagtcggtcc taacaaaatc ttgaggagct      900

ccaccacagt caaggttttt gctaaaccag aaatccctgt gattgtggaa aataactcca      960

cggatgtctt ggtagagaga agatttacct gcttactaaa gaatgtattt cccaaagcaa     1020

atatcacatg gtttatagat ggaagttttc ttcatgatga aaaagaagga atatatatta     1080

ctaatgaaga gagaaaaggc aaagatggat ttttggaact gaagtctgtt ttaacaaggg     1140

tacatagtaa taaaccagcc caatcagaca acttgaccat ttggtgtatg gctctgtctc     1200

cagtcccagg aaataaagtg tggaacatct catcagaaaa gatcactttt ctcttaggtt     1260

ctgaaatttc ctcaacagac cctccactga gtgttacaga atctaccctt gacacccaac     1320

cttctccagc cagcagtgta tctcctgcaa gatatccagc tacatcttca gtgacccttg     1380

tagatgtgag tgccttgagg ccaaacacca ctcctcaacc cagcaattcc agtatgacta     1440

cccgaggctt caactatccc tggacctcca gtgggacaga taccaaaaaa tcagtttcac     1500

ggatacctag tgaaacatac agttcatccc cgtcaggtgc aggctcaaca cttcatgaca     1560

atgtctttac cagcacagcc agagcatttt cagaagtccc cacaactgcc aatggatcta     1620

cgaaaactaa tcacgtccat atcactggta ttgtggtcaa taagcccaaa gatggaatgt     1680

cctggccagt gattgtagca gctttactct tttgctgcat gatattgttt ggtcttggag     1740

tgagaaaatg gtgtcagtac caaaaagaaa taatggaaag acctccacct ttcaagccac     1800

caccacctcc catcaagtac acttgcattc aagagcccaa cgaaagtgat ctgccttatc     1860

atgagatgga gaccctctag tctcgtgaga ctttgcccca tggcagaact ctgctggaat     1920

cctattgaga aggtagacat tgtgctttat taatatagtc gctcttcagc catgcctttg     1980

ctgcagctga aatggaagtc agaagtgagt gacctgtttt cccagcaact caccctcttc     2040

catctccaaa cgcctgaagc ttaaccaaga gtgagaggat atgtcatgtt cacactcaat     2100

gcaattcgta gtggttttct tgcttatgta agaagtacat attagtctgc catctttaaa     2160

aaaaaataca gtattttcat ttaaattctc tgatggaggg acaacaatgg tttcaactgt     2220

atgcccatgc ctgatcctct tatttgaaca tctatcaaca ttgtaaactc tttgccaaaa     2280

tcctggggct ttgctgcatt ccctaagata attacaggaa aaagaaaatg taaaagtgct     2340

aacaaggctg ccaagtaatg gagaagtatg gttagtcttc atattgaaat tctgttgctt     2400

attttcatgg aaggaaacag aatactttgc acaggaacca cattttcaat cctccttcac     2460

tgtcttccta ccatgttcag cccagactcc tgccacatgg accaggatga agagggatca     2520

aagagataat tagccaaaaa cccagtagcc tagaagatac aaaactccac tggcctctaa     2580

aattatatta gccaagagtg gtttcatttg agtgccttcg tgtgtatgtc catcaaactg     2640

gaaccaaact gttttgtaag taaacaggca gcctaagccc aaccctactt tctaattcca     2700

gttattctct ttttcatctg gggatttacc tgttcattta atctgcctgt tttgatctgt     2760

tttgaaaaag ataaagagcc tcaaatcaga ccagcactga ttaattaacc ctgctcctac     2820

caatcttttt taaagcagtt gaagcagaat gtataggtgt cagagaagaa acctagtcag     2880

ccagacgtgc tctgtattca gcaatagttt gtgaatgaat aaattactaa tcctccttgt     2940

cgcttgaaac cttcccacac tccctgctcc aggagggaaa aacagatgtt gttgacagat     3000

agagtgatag gcaaattctg tgtggacttt agtcccaaaa ggaaacttta gttcacttgc     3060

agtatgctta tccttgactg cacatgagaa tgccttgtgc agagttattt ggagattatg     3120

tctttttctt aaacaccatg gctgtcacac ttcagttcaa ttaaatcaga atgtctgagg     3180

agtgagacac aggcatcaac actctcaaat gattcacatg ttcagccaaa gttgagaacc     3240

atcgagcctg tggaagttct ttctcatggc tcagaatctt aggtaggtgc ttaactcttg     3300

tggtggccag cctccaagat gagccccagt gttcttgcct cctactattc acatctttat     3360

gtggtcccct ccaatgctga atacagatga tttgtgtaac ctgaggccag gattaagggg     3420

aggcaatcaa tgcacctagg gaaaaaattt aaggaggtat tcacactcag ggtcatgcac     3480

ttgcacaatg ttgagaatga gtaccactct caccattggt atagccaaaa aagcttggaa     3540

gtgaccaagg ctaggtcaca aaatacactg tggcttcttc tttgatctct ctttgaccat     3600

actgacactg ggaaaagccc attcccatgc catgaagaca ccaaggcagc cctattgaga     3660

aatctacctg tcgtggccgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg     3720

ccgaggtggg tggatcacga ggtcaggaga tcgagaccat cctggctaac acagtgaaac     3780

cccgtctcta ctaaaaatac aaaaaattag ccgggtgtgg tgtcgggcac ctgtagtccc     3840

agctactcag gaggctgagg caggagaagg gtgggaaccc gggaggcaga gcttgcagtg     3900

agccgagatt gtgccactgc acactccaat ctgggtgaaa gaccgagact ccgcctcaaa     3960

aaaaaaaaaa aaagaaagaa agaaagaaag aaagaaatct acctgtcaag gaactaaggt     4020

attttgctaa caagcaccaa cttgccagcc atgtaaggga gccatcttgg aagcagatcc     4080

tccagcctcc agtcaagtct tcagataatt gcaacttcag ttgatctttt gaccaagacc     4140

tcaagagagc cagaactacc cagctaagcc ttttactaaa tttctgaact tctaacacta     4200

ttagataata agtgcttatt gtttaacacc attaattttg agtataattt gttacatagc     4260

gacagataac tatacagctc aacaactaga aaaataaact gtttacctgc cttaattatt     4320

tatctttagt tccttattag ttctcaagaa acaaatgcta gcttcatatg tatggctgtt     4380

gctttgcttc atgtgtatgg ctatttgtat ttaacaagac ttaatcatca gta            4433


<210>  5
<211>  1710
<212>  DNA
<213>  Homo sapiens

<400>  5
atggagaaaa aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag       60

ggagtttggg aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat      120

gtcaacctga cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag      180

gtcaccaata agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc      240

tatgggagac cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa      300

tggactctgc acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt      360

gttctgtatc cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt      420

acagcagatg aatggaacag caaccatacg atagaaatag agataaatca gactctggaa      480

ataccatgct ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg      540

gtggaggata atggaactca ggaaacactt atctcccaaa atcacctcat cagcaattcc      600

acattactta aagatagagt caagcttggt acagactaca gactccacct ctctccagtc      660

caaatcttcg atgatgggcg gaagttctct tgccacatta gagtcggtcc taacaaaatc      720

ttgaggagct ccaccacagt caaggttttt gctaaaccag aaatccctgt gattgtggaa      780

aataactcca cggatgtctt ggtagagaga agatttacct gcttactaaa gaatgtattt      840

cccaaagcaa atatcacatg gtttatagat ggaagttttc ttcatgatga aaaagaagga      900

atatatatta ctaatgaaga gagaaaaggc aaagatggat ttttggaact gaagtctgtt      960

ttaacaaggg tacatagtaa taaaccagcc caatcagaca acttgaccat ttggtgtatg     1020

gctctgtctc cagtcccagg aaataaagtg tggaacatct catcagaaaa gatcactttt     1080

ctcttaggtt ctgaaatttc ctcaacagac cctccactga gtgttacaga atctaccctt     1140

gacacccaac cttctccagc cagcagtgta tctcctgcaa gatatccagc tacatcttca     1200

gtgacccttg tagatgtgag tgccttgagg ccaaacacca ctcctcaacc cagcaattcc     1260

agtatgacta cccgaggctt caactatccc tggacctcca gtgggacaga taccaaaaaa     1320

tcagtttcac ggatacctag tgaaacatac agttcatccc cgtcaggtgc aggctcaaca     1380

cttcatgaca atgtctttac cagcacagcc agagcatttt cagaagtccc cacaactgcc     1440

aatggatcta cgaaaactaa tcacgtccat atcactggta ttgtggtcaa taagcccaaa     1500

gatggaatgt cctggccagt gattgtagca gctttactct tttgctgcat gatattgttt     1560

ggtcttggag tgagaaaatg gtgtcagtac caaaaagaaa taatggaaag acctccacct     1620

ttcaagccac caccacctcc catcaagtac acttgcattc aagagcccaa cgaaagtgat     1680

ctgccttatc atgagatgga gaccctctag                                      1710


<210>  6
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
        515                 520                 525             


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
    530                 535                 540                 


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
                565                 570                 575     


Leu Pro Tyr His Glu Met Glu Thr Leu 
            580                 585 


<210>  7
<211>  1651
<212>  DNA
<213>  Homo sapiens

<400>  7
ttcctgtcta cgtttcattt cctgggggct tgccaagtga taaacagacc caggcgtgtg       60

tggtagagtt cgggtttttt agcacgaagt gggtggctgg agtttgcttg aaaacatcaa      120

ttgactttgt gatcattaca gaaatgctgg tgtaaggtgt tcagaagaca atggagaaaa      180

aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag ggagtttggg      240

aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat gtcaacctga      300

cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag gtcaccaata      360

agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc tatgggagac      420

cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa tggactctgc      480

acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt gttctgtatc      540

cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt acagcagatg      600

aatggaacag caaccatacg atagaaatag agataaatca gactctggaa ataccatgct      660

ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg gtggaggata      720

atggaactca ggaaacactt atctcccaaa atcacctcat cagcaattcc acattactta      780

aagatagagt caagcttggt acagactaca gactccacct ctctccagtc caaatcttcg      840

atgatgggcg gaagttctct tgccacatta gagtcggtcc taacaaaatc ttgaggagct      900

ccaccacagt caaggttttt gctaaaccag aaatccctgt gattgtggaa aataactcca      960

cggatgtctt ggtagagaga agatttacct gcttactaaa gaatgtattt cccaaagcaa     1020

atatcacatg gtttatagat ggaagttttc ttcatgatga aaaagaagga atatatatta     1080

ctaatgaaga gagaaaaggc aaagatggat ttttggaact gaagtctgtt ttaacaaggg     1140

tacatagtaa taaaccagcc caatcagaca acttgaccat ttggtgtatg gctctgtctc     1200

cagtcccagg aaataaagtg tggaacatct catcagaaaa gatcactttt ctcttaggtt     1260

ctgaaatttc ctcaacagac cctccactga gtgttacaga atctaccctt gacacccaac     1320

cttctccagc cagcagtgta tctcctgcaa gtaagaatgt tttcacactg agctattgat     1380

ttaaccaagc agattgataa cgataaaatt tcagcaaact tgcatcattc atgcctgttt     1440

cttagctatg acttttttgg ggctgaaatt gggttttatt ttttaacagc tttattgaga     1500

tataattcac gtcacattaa cttgcccatt taaaatgtat gatctaatgg tttttagtat     1560

gttcacagac ttgtacaacc atgactacag ccaatttcag aacattttca tcatctaata     1620

aagaaactcc taaacaaaaa aaaaaaaaaa a                                    1651


<210>  8
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  8
atggagaaaa aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag       60

ggagtttggg aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat      120

gtcaacctga cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag      180

gtcaccaata agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc      240

tatgggagac cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa      300

tggactctgc acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt      360

gttctgtatc cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt      420

acagcagatg aatggaacag caaccatacg atagaaatag agataaatca gactctggaa      480

ataccatgct ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg      540

gtggaggata atggaactca ggaaacactt atctcccaaa atcacctcat cagcaattcc      600

acattactta aagatagagt caagcttggt acagactaca gactccacct ctctccagtc      660

caaatcttcg atgatgggcg gaagttctct tgccacatta gagtcggtcc taacaaaatc      720

ttgaggagct ccaccacagt caaggttttt gctaaaccag aaatccctgt gattgtggaa      780

aataactcca cggatgtctt ggtagagaga agatttacct gcttactaaa gaatgtattt      840

cccaaagcaa atatcacatg gtttatagat ggaagttttc ttcatgatga aaaagaagga      900

atatatatta ctaatgaaga gagaaaaggc aaagatggat ttttggaact gaagtctgtt      960

ttaacaaggg tacatagtaa taaaccagcc caatcagaca acttgaccat ttggtgtatg     1020

gctctgtctc cagtcccagg aaataaagtg tggaacatct catcagaaaa gatcactttt     1080

ctcttaggtt ctgaaatttc ctcaacagac cctccactga gtgttacaga atctaccctt     1140

gacacccaac cttctccagc cagcagtgta tctcctgcaa gtaagaatgt tttcacactg     1200

agctattga                                                             1209


<210>  9
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
            180                 185                 190         


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
        195                 200                 205             


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
    210                 215                 220                 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
225                 230                 235                 240 


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
                245                 250                 255     


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
            260                 265                 270         


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
        275                 280                 285             


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
    290                 295                 300                 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
305                 310                 315                 320 


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
                325                 330                 335     


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
            340                 345                 350         


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
        355                 360                 365             


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
    370                 375                 380                 


Ser Pro Ala Ser Ser Val Ser Pro Ala Ser Lys Asn Val Phe Thr Leu 
385                 390                 395                 400 


Ser Tyr 
        


<210>  10
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  10
agaattcttt ggcaggggcg accttagaat cctggggagg agcgagaatg gaatcccggg       60

gaggaacagg ggtggaatcc ggggggcggg gtcagaacgc caggaggggg cggggccgga      120

gccagggtcg gcttgactcg ggggagcagc gggtggatcc tgtgacgtca gcgggttcga      180

accgccggag ctgagcgaga ggccgggggt gccgagccgg gcggggagag ctgggccggg      240

agagcagaac agggaggcta gagcgcagcg ggaaccggcc cggagccgga gccggagccc      300

cacaggcacc tactaaaccg cccagccgat cggcccccac agagtggccc gcgggcctcc      360

ggccgggccc agtcccctcc cgggccctcc atggcccggg ccgctgccct cctgccgtcg      420

agatcgccgc cgacgccgct gctgtggccg ctgctgctgc tgctgctcct ggaaaccgga      480

gcccaggatg tgcgagttca agtgctaccc gaggtgcgag gccagctcgg gggcaccgtg      540

gagctgccgt gccacctgct gccacctgtt cctggactgt acatctccct ggtgacctgg      600

cagcgcccag atgcacctgc gaaccaccag aatgtggccg ccttccaccc taagatgggt      660

cccagcttcc ccagcccgaa gcctggcagc gagcggctgt ccttcgtctc tgccaagcag      720

agcactgggc aagacacaga ggcagagctc caggacgcca cgctggccct ccacgggctc      780

acggtggagg acgagggcaa ctacacttgc gagtttgcca ccttccccaa ggggtccgtc      840

cgagggatga cctggctcag agtcatagcc aagcccaaga accaagctga ggcccagaag      900

gtcacgttca gccaggaccc tacgacagtg gccctctgca tctccaaaga gggccgccca      960

cctgcccgga tctcctggct ctcatccctg gactgggaag ccaaagagac tcaggtgtca     1020

gggaccctgg ccggaactgt cactgtcacc agccgcttca ccttggtgcc ctcgggccga     1080

gcagatggtg tcacggtcac ctgcaaagtg gagcatgaga gcttcgagga accagccctg     1140

atacctgtga ccctctctgt acgctaccct cctgaagtgt ccatctccgg ctatgatgac     1200

aactggtacc tcggccgtac tgatgccacc ctgagctgtg acgtccgcag caacccagag     1260

cccacgggct atgactggag cacgacctca ggcaccttcc cgacctccgc agtggcccag     1320

ggctcccagc tggtcatcca cgcagtggac agtctgttca ataccacctt cgtctgcaca     1380

gtcaccaatg ccgtgggcat gggccgcgct gagcaggtca tctttgtccg agaaaccccc     1440

agggcctcgc cccgagatgt gggcccgctg gtgtgggggg ccgtgggggg gacactgctg     1500

gtgctgctgc ttctggctgg ggggtccttg gccttcatcc tgctgagggt gaggaggagg     1560

aggaagagcc ctggaggagc aggaggagga gccagtggcg acgggggatt ctacgatccg     1620

aaagctcagg tgttgggaaa tggggacccc gtcttctgga caccagtagt ccctggtccc     1680

atggaaccag atggcaagga tgaggaggag gaggaggagg aagagaaggc agagaaaggc     1740

ctcatgttgc ctccaccccc agcactcgag gatgacatgg agtcccagct ggacggctcc     1800

ctcatctcac ggcgggcagt ttatgtgtga cctggacaca gacagagaca gagccaggcc     1860

cggccctccc gcccccgacc tgaccacgcc ggcctagggt tccagactgg ttggacttgt     1920

tcgtctggac gacactggag tggaacactg cctcccactt tcttgggact tggagggagg     1980

tggaacagca cactggactt ctcccgtctc tagggctgca tggggagccc ggggagctga     2040

gtagtgggga tccagagagg acccccgccc ccagagactt ggttttggct ccagccttcc     2100

cctggccccg tgacactcag gagttaataa atgccttgga ggaaaacatc aaaaaaaaaa     2160

aaaaaa                                                                2166


<210>  11
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcccggg ccgctgccct cctgccgtcg agatcgccgc cgacgccgct gctgtggccg       60

ctgctgctgc tgctgctcct ggaaaccgga gcccaggatg tgcgagttca agtgctaccc      120

gaggtgcgag gccagctcgg gggcaccgtg gagctgccgt gccacctgct gccacctgtt      180

cctggactgt acatctccct ggtgacctgg cagcgcccag atgcacctgc gaaccaccag      240

aatgtggccg ccttccaccc taagatgggt cccagcttcc ccagcccgaa gcctggcagc      300

gagcggctgt ccttcgtctc tgccaagcag agcactgggc aagacacaga ggcagagctc      360

caggacgcca cgctggccct ccacgggctc acggtggagg acgagggcaa ctacacttgc      420

gagtttgcca ccttccccaa ggggtccgtc cgagggatga cctggctcag agtcatagcc      480

aagcccaaga accaagctga ggcccagaag gtcacgttca gccaggaccc tacgacagtg      540

gccctctgca tctccaaaga gggccgccca cctgcccgga tctcctggct ctcatccctg      600

gactgggaag ccaaagagac tcaggtgtca gggaccctgg ccggaactgt cactgtcacc      660

agccgcttca ccttggtgcc ctcgggccga gcagatggtg tcacggtcac ctgcaaagtg      720

gagcatgaga gcttcgagga accagccctg atacctgtga ccctctctgt acgctaccct      780

cctgaagtgt ccatctccgg ctatgatgac aactggtacc tcggccgtac tgatgccacc      840

ctgagctgtg acgtccgcag caacccagag cccacgggct atgactggag cacgacctca      900

ggcaccttcc cgacctccgc agtggcccag ggctcccagc tggtcatcca cgcagtggac      960

agtctgttca ataccacctt cgtctgcaca gtcaccaatg ccgtgggcat gggccgcgct     1020

gagcaggtca tctttgtccg agaaaccccc agggcctcgc cccgagatgt gggcccgctg     1080

gtgtgggggg ccgtgggggg gacactgctg gtgctgctgc ttctggctgg ggggtccttg     1140

gccttcatcc tgctgagggt gaggaggagg aggaagagcc ctggaggagc aggaggagga     1200

gccagtggcg acgggggatt ctacgatccg aaagctcagg tgttgggaaa tggggacccc     1260

gtcttctgga caccagtagt ccctggtccc atggaaccag atggcaagga tgaggaggag     1320

gaggaggagg aagagaaggc agagaaaggc ctcatgttgc ctccaccccc agcactcgag     1380

gatgacatgg agtcccagct ggacggctcc ctcatctcac ggcgggcagt ttatgtgtga     1440


<210>  12
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Arg Ala 
            340                 345                 350         


Ser Pro Arg Asp Val Gly Pro Leu Val Trp Gly Ala Val Gly Gly Thr 
        355                 360                 365             


Leu Leu Val Leu Leu Leu Leu Ala Gly Gly Ser Leu Ala Phe Ile Leu 
    370                 375                 380                 


Leu Arg Val Arg Arg Arg Arg Lys Ser Pro Gly Gly Ala Gly Gly Gly 
385                 390                 395                 400 


Ala Ser Gly Asp Gly Gly Phe Tyr Asp Pro Lys Ala Gln Val Leu Gly 
                405                 410                 415     


Asn Gly Asp Pro Val Phe Trp Thr Pro Val Val Pro Gly Pro Met Glu 
            420                 425                 430         


Pro Asp Gly Lys Asp Glu Glu Glu Glu Glu Glu Glu Glu Lys Ala Glu 
        435                 440                 445             


Lys Gly Leu Met Leu Pro Pro Pro Pro Ala Leu Glu Asp Asp Met Glu 
    450                 455                 460                 


Ser Gln Leu Asp Gly Ser Leu Ile Ser Arg Arg Ala Val Tyr Val 
465                 470                 475                 


<210>  13
<211>  2868
<212>  DNA
<213>  Homo sapiens

<400>  13
agaattcttt ggcaggggcg accttagaat cctggggagg agcgagaatg gaatcccggg       60

gaggaacagg ggtggaatcc ggggggcggg gtcagaacgc caggaggggg cggggccgga      120

gccagggtcg gcttgactcg ggggagcagc gggtggatcc tgtgacgtca gcgggttcga      180

accgccggag ctgagcgaga ggccgggggt gccgagccgg gcggggagag ctgggccggg      240

agagcagaac agggaggcta gagcgcagcg ggaaccggcc ggagccggag ccggagcccc      300

acaggcacct actaaaccgc ccagccgatc ggcccccaca gagtggcccg cgggcctccg      360

gccgggccca gtcccctccc gggccctcca tggcccgggc cgctgccctc ctgccgtcga      420

gatcgccgcc gacgccgctg ctgtggccgc tgctgctgct gctgctcctg gaaaccggag      480

cccaggatgt gcgagttcaa gtgctacccg aggtgcgagg ccagctcggg ggcaccgtgg      540

agctgccgtg ccacctgctg ccacctgttc ctggactgta catctccctg gtgacctggc      600

agcgcccaga tgcacctgcg aaccaccaga atgtggccgc cttccaccct aagatgggtc      660

ccagcttccc cagcccgaag cctggcagcg agcggctgtc cttcgtctct gccaagcaga      720

gcactgggca agacacagag gcagagctcc aggacgccac gctggccctc cacgggctca      780

cggtggagga cgagggcaac tacacttgcg agtttgccac cttccccaag gggtccgtcc      840

gagggatgac ctggctcaga gtcatagcca agcccaagaa ccaagctgag gcccagaagg      900

tcacgttcag ccaggaccct acgacagtgg ccctctgcat ctccaaagag ggccgcccac      960

ctgcccggat ctcctggctc tcatccctgg actgggaagc caaagagact caggtgtcag     1020

ggaccctggc cggaactgtc actgtcacca gccgcttcac cttggtgccc tcgggccgag     1080

cagatggtgt cacggtcacc tgcaaagtgg agcatgagag cttcgaggaa ccagccctga     1140

tacctgtgac cctctctgta cgctaccctc ctgaagtgtc catctccggc tatgatgaca     1200

actggtacct cggccgtact gatgccaccc tgagctgtga cgtccgcagc aacccagagc     1260

ccacgggcta tgactggagc acgacctcag gcaccttccc gacctccgca gtggcccagg     1320

gctcccagct ggtcatccac gcagtggaca gtctgttcaa taccaccttc gtctgcacag     1380

tcaccaatgc cgtgggcatg ggccgcgctg agcaggtcat ctttgtccga gagaccccca     1440

acacagcagg cgcaggggcc acaggcggca tcatcggggg catcatcgcc gccatcattg     1500

ctactgctgt ggctgccacg ggcatcctta tctgccggca gcagcggaag gagcagacgc     1560

tgcagggggc agaggaggac gaagacctgg agggacctcc ctcctacaag ccaccgaccc     1620

caaaagcgaa gctggaggca caggagatgc cctcccagct cttcactctg ggggcctcgg     1680

agcacagccc actcaagacc ccctactttg atgctggcgc ctcatgcact gagcaggaaa     1740

tgcctcgata ccatgagctg cccaccttgg aagaacggtc aggacccttg caccctggag     1800

ccacaagcct ggggtccccc atcccggtgc ctccagggcc acctgctgtg gaagacgttt     1860

ccctggatct agaggatgag gagggggagg aggaggaaga gtatctggac aagatcaacc     1920

ccatctatga tgctctgtcc tatagcagcc cctctgattc ctaccagggc aaaggctttg     1980

tcatgtcccg ggccatgtat gtgtgagctg ccatgcgcct ggcgtctcac atctcacctg     2040

ttgatccctt agctttcttg ccaaggatct agtgccccct gacctctggc caggccactg     2100

tcagttaaca catatgcatt ccatttgtga tgtctacctt ggtggctcca ctatgacccc     2160

taacccatga gcccagagaa attcaccgtg ataatggaat cctggcaacc ttatctcatg     2220

aggcaggagg tggggaaggt gcttctgcac aacctctgat cccaaggact cctctcccag     2280

actgtgacct tagaccatac ctctcacccc ccaatgcctc gactccccca aaatcacaaa     2340

gaagacccta gacctataat ttgtcttcag gtagtaaatt cccaataggt ctgctggagt     2400

gggcgctgag ggctccctgc tgctcagacc tgagccctcc aggcagcagg gtcccactta     2460

ccccctcccc accctgttcc ccaaaggtgg gaaagagggg attccccagc ccaaggcagg     2520

gttttcccag caccctcctg taagcagaag tctcagggtc cagacccttc cctgagcccc     2580

cacccccacc ccaattcctg cctaccaagc aagcagcccc agcctagggt cagacagggt     2640

gagcctcata cagactgtgc cttgatggcc ccagccttgg gagaagaatt tactgttaac     2700

ctggaagact actgaatcat tttacccttg cccagtggaa taggacctaa acatccccct     2760

tccggggaaa gtgggtcatc tgaattgggg gtagcaattg atactgtttt gtaaactaca     2820

tttcctacaa aatatgaatt tatactttga ccaggaaaaa aaaaaaaa                  2868


<210>  14
<211>  1617
<212>  DNA
<213>  Homo sapiens

<400>  14
atggcccggg ccgctgccct cctgccgtcg agatcgccgc cgacgccgct gctgtggccg       60

ctgctgctgc tgctgctcct ggaaaccgga gcccaggatg tgcgagttca agtgctaccc      120

gaggtgcgag gccagctcgg gggcaccgtg gagctgccgt gccacctgct gccacctgtt      180

cctggactgt acatctccct ggtgacctgg cagcgcccag atgcacctgc gaaccaccag      240

aatgtggccg ccttccaccc taagatgggt cccagcttcc ccagcccgaa gcctggcagc      300

gagcggctgt ccttcgtctc tgccaagcag agcactgggc aagacacaga ggcagagctc      360

caggacgcca cgctggccct ccacgggctc acggtggagg acgagggcaa ctacacttgc      420

gagtttgcca ccttccccaa ggggtccgtc cgagggatga cctggctcag agtcatagcc      480

aagcccaaga accaagctga ggcccagaag gtcacgttca gccaggaccc tacgacagtg      540

gccctctgca tctccaaaga gggccgccca cctgcccgga tctcctggct ctcatccctg      600

gactgggaag ccaaagagac tcaggtgtca gggaccctgg ccggaactgt cactgtcacc      660

agccgcttca ccttggtgcc ctcgggccga gcagatggtg tcacggtcac ctgcaaagtg      720

gagcatgaga gcttcgagga accagccctg atacctgtga ccctctctgt acgctaccct      780

cctgaagtgt ccatctccgg ctatgatgac aactggtacc tcggccgtac tgatgccacc      840

ctgagctgtg acgtccgcag caacccagag cccacgggct atgactggag cacgacctca      900

ggcaccttcc cgacctccgc agtggcccag ggctcccagc tggtcatcca cgcagtggac      960

agtctgttca ataccacctt cgtctgcaca gtcaccaatg ccgtgggcat gggccgcgct     1020

gagcaggtca tctttgtccg agagaccccc aacacagcag gcgcaggggc cacaggcggc     1080

atcatcgggg gcatcatcgc cgccatcatt gctactgctg tggctgccac gggcatcctt     1140

atctgccggc agcagcggaa ggagcagacg ctgcaggggg cagaggagga cgaagacctg     1200

gagggacctc cctcctacaa gccaccgacc ccaaaagcga agctggaggc acaggagatg     1260

ccctcccagc tcttcactct gggggcctcg gagcacagcc cactcaagac cccctacttt     1320

gatgctggcg cctcatgcac tgagcaggaa atgcctcgat accatgagct gcccaccttg     1380

gaagaacggt caggaccctt gcaccctgga gccacaagcc tggggtcccc catcccggtg     1440

cctccagggc cacctgctgt ggaagacgtt tccctggatc tagaggatga ggagggggag     1500

gaggaggaag agtatctgga caagatcaac cccatctatg atgctctgtc ctatagcagc     1560

ccctctgatt cctaccaggg caaaggcttt gtcatgtccc gggccatgta tgtgtga        1617


<210>  15
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  16
<211>  5903
<212>  DNA
<213>  Homo sapiens

<400>  16
agcgggactg agcgccggga gagacctgcg caggcgcagg cgcgcgggga gggccagcct       60

gggtggccca ccccgcgcct ggcgggactg gccgccaact cccctccgct ccagtcactt      120

gtctggagct tgaagaagtg ggtattcccc ttcccacccc aggcactgga ggagcggccc      180

cccggggatt ccaggacctg agctccggga gctggactcg cagcgaccgc ggcagagcga      240

gcgggcgccg ggaagcgagg agacgcccgc gggaggccca gctgctcgga gcaactggca      300

tggcccgagc catggccgcc gcgtggccgc tgctgctggt ggcgctactg gtgctgtcct      360

ggccaccccc aggaaccggg gacgtcgtcg tgcaggcgcc cacccaggtg cccggcttct      420

tgggcgactc cgtgacgctg ccctgctacc tacaggtgcc caacatggag gtgacgcatg      480

tgtcacagct gacttgggcg cggcatggtg aatctggcag catggccgtc ttccaccaaa      540

cgcagggccc cagctattcg gagtccaaac ggctggaatt cgtggcagcc agactgggcg      600

cggagctgcg gaatgcctcg ctgaggatgt tcgggttgcg cgtagaggat gaaggcaact      660

acacctgcct gttcgtcacg ttcccgcagg gcagcaggag cgtggatatc tggctccgag      720

tgcttgccaa gccccagaac acagctgagg ttcagaaggt ccagctcact ggagagccag      780

tgcccatggc ccgctgcgtc tccacagggg gtcgcccgcc agcccaaatc acctggcact      840

cagacctggg cgggatgccc aatacgagcc aggtgccagg gttcctgtct ggcacagtca      900

ctgtcaccag cctctggata ttggtgccct caagccaggt ggacggcaag aatgtgacct      960

gcaaggtgga gcacgagagc tttgagaagc ctcagctgct gactgtgaac ctcaccgtgt     1020

actacccccc agaggtatcc atctctggct atgataacaa ctggtacctt ggccagaatg     1080

aggccaccct gacctgcgat gctcgcagca acccagagcc cacaggctat aattggagca     1140

cgaccatggg tcccctgcca ccctttgctg tggcccaggg cgcccagctc ctgatccgtc     1200

ctgtggacaa accaatcaac acaactttaa tctgcaacgt caccaatgcc ctaggagctc     1260

gccaggcaga actgaccgtc caggtcaaag agggacctcc cagtgagcac tcaggcatgt     1320

cccgtaacgc catcatcttc ctggttctgg gaatcctggt ttttctgatc ctgctgggga     1380

tcgggattta tttctattgg tccaaatgtt cccgtgaggt cctttggcac tgtcatctgt     1440

gtccctcgag tacagagcat gccagcgcct cagctaatgg gcatgtctcc tattcagctg     1500

tgagcagaga gaacagctct tcccaggatc cacagacaga gggcacaagg tgacagcgtc     1560

gggactgaga ggggagagag actggagctg gcaaggacgt gggcctccag agttggaccc     1620

gaccccaatg gatgaagacc ccctccaaag agaccagcct ccctccctgt gccagacctc     1680

aaaacgacgg gggcaggtgc aagttcatag gtctccaaga ccaccctcct ttcatttgct     1740

agaaggactc actagactca ggaaagctgt taggctcaca gttacagttt attacagtaa     1800

aaggacagag attaagatca gcaaagggag gaggtgcaca gcacacgttc cacgacagat     1860

gaggcgacgg cttccatctg ccctctccca gtggagccat ataggcagca cctgattctc     1920

acagcaacat gtgacaacat gcaagaagta ctgccaatac tgccaaccag agcagctcac     1980

tcgagatctt tgtgtccaga gttttttgtt tgtcttgaga cagggtctgg ctctgttggc     2040

agactagagt acagtggtga gatcacagtt cattgcagcc ttgacttctc aacgccaagt     2100

catcctccca cctcagcctc ctgagtagct atgactacag gtatgtgcca ccacgtctgg     2160

ctaatctttt tattatttgt aaagtcgagg tttccctgtg ttgcccaggc tggtcttgaa     2220

ctcttggctc caagtgatac ttctgccttg gcctcccaaa gtgctgaatt aagcagctca     2280

ccatccacac ggctgacctc atacatcaag ccaataccgt gtggcccaag acccccacca     2340

taaatcacat cattagcatg aaccacccag agtggcccaa gactccaaga tcagctacca     2400

ggcaggatat tccaagggct tagagatgaa tgcccaggag ctgaggataa agggcccgat     2460

ctttctttgg gcaaggttaa gcctttactg catagcagac cacacagaag ggtgtgggcc     2520

accagagaat tttggtaaaa atttggcctc tggccttgag cttctaaatc tctgtatccg     2580

tcagatctct gtggttacaa gaaacagcca ctgaccctgg tcaccagagg ctgcaattca     2640

ggccgcaagc agctgcctgg ggggtgtcca aggagcagag aaaactacta gatgtgaact     2700

tgaagaaggt tgtcagctgc agccactttc tgccagcatc tgcagccact ttctgccagc     2760

atctgcagcc agcaagctgg gactggcagg aaataaccca caaaagaagc aaatgcaatt     2820

tccaacacaa gggggaaggg atgcaggggg aggcagcgct gcagttgctc aggacacgct     2880

cctataggac caagatggat gcgacccaag acccaggagg cccagctgct cagtgcaact     2940

gacaagttaa aaaggtctat gatcttgagg gcagacagca gaattcctct tataaagaaa     3000

actgtttggg aaaatacgtt gagggagaga agaccttggg ccaagatgct aaatgggaat     3060

gcaaagcttg agctgctctg caagagaaaa taagcaggac agaggatttg ctctggacag     3120

agatggaaga gccgggaaca gagaagtgtg gggaagagat aggaaccagc aggatggcag     3180

gggcaaaggg ctcaagggtg aggaggccag tgggacccca cagagttggg gagataaagg     3240

aacattggtt gctttggtgg cacgtaagct ccttgtctgt ctccagcacc cagaatctca     3300

ttaaagctta tttattgtac ctccagcggc tgtgtgcaat ggggtctttt gtggaaatca     3360

aggagcagac aggtttcatg tgtactgtca ccacgtggga tggaaccaga ggcatggaag     3420

caagacgcta aatgaagagg gccataaggg ctgggattcc caggcacctt aggaacagct     3480

tgtctttttt tttttcctct ccaaaaaaaa tgtttaaggg acggtgtctc ctgtcaccca     3540

ggctggagtg caatggcacg atcatagctc attgcagcct ctaactccgg ggctcaagca     3600

atcctcccac ctcagcctac caagtagctg tgaccacagc tgcccctcac catgctaagc     3660

taattttttt aattagatag tacataaacg tcccaaaatt agaagataaa aagacatgag     3720

ggatccattc taatttgtgt ttggagtgta atggtccagc tccattcttc tgcacatgga     3780

tatccagttt tacacaacac tgtgaatgta atgaatgcca ctgaatcata cactcaaaaa     3840

tagctaaaat ggcaaattgt ctgttatctc tttttaacca ccatttttga aaattaatta     3900

taccaaaaaa ccattgaata gtgcacttta tttatttatt tatttgttta tttatttatt     3960

tattttagaa ataagagtct cactttgttg cccaggctgg agtgcagtgg cgtgatcatg     4020

gctcattgca gcctcgacct gctgggctcg ggctatcctt ccatctcagc ctcccgagta     4080

gctgggacta taggtgggcg ccaccccacc tggctaaatc tctttttaac ttttgtagag     4140

ataggcatct cgctatgttg cctaggctgg gctggaactc ctgggctcaa gtgctcctcc     4200

tgccttggcc tcccaaagcg ctaggattac agatgtgagc caccgcgccc accctgaacc     4260

ttactttttt tgctcagttt ctggtaattc agagaatgcc tcctgagttg ttctacaccc     4320

acctcatatt ccatgggagg gctgtacagg gcttttttaa cgaggcctct aaggacaggc     4380

atttgtatcc tttccagcct ttcactatta caatgttgta gtgaataact ttacacactg     4440

tcatttattt tacttttttt tttttttatt ttagagaaag gaatcttgcc atcttgccca     4500

ggctggtctc aaattcctgg gcccaaacaa tcctcccgcc ttggcctcct aaagtactgg     4560

gatttatagg cataagccac cgtgcctggc caatgcacac tgtcatttag ctcatgttaa     4620

cacctgagtg taggacacac tcctggaggt ggaattgctg ggccaaagag tatgtttctt     4680

gtcattgtga tagatattga caaatgaacc ctcacagaag ttgtgctgag ttctgttccc     4740

accagcgacg taggcgatga cctttttctg gagggagggg gcatccttgg agtccacaga     4800

gccaggaatg gagagtgggc ccagaatttt ggtataggtg ttgtataaac ttatagtaag     4860

gttaagaaaa ccgcaactat ccttatcaga gacttggcgg ggggcagggt atgatggaga     4920

tcataaggag gctaaaacac tccacaccct ccctctgcat tgctcctgca cgggagtcgg     4980

gaatcttttc aggttgatac gatctcacct tgaggagctg tgaggtccca gaagcctctg     5040

ggttgcagat tgcttggggt gaaaatgtct gtgctactga aatctaactt tttacaaaaa     5100

attacgggct gggcgcagtg gctcacgcct gtaatcccag cactttggga ggctgcagcg     5160

ggtggatcac ttgaggtaag gagttcaaga ccagaccata gtgaaaccgt gtctctacaa     5220

aaaaaattag ccaggtgtgg tggtgcatgc ttgtaatccc agctactcag aaggctgagg     5280

tgggagaatc ccttgaaccc gggaagtgga ggctggagta aaccatgatc gagttactgc     5340

actccagcct gggtgacaag agtgagactc tgtctccaaa aaaaaaaaaa aaaaaaaaaa     5400

aactggattg cctggctcta ctccgggcac agcatgcagg cccagttctg ctgctctgct     5460

gtttgttctg ctttcctcca catattggca tcaccctctg gtgccaagat ggctgctgca     5520

ttccaggcat cacatccaga ctcagaccca gagaagctgc ccatccctac ctgggtgagc     5580

ctttgtagga acgagaaacc gcatccagca gcagaaacct cacccagcag cgtcttttcc     5640

ggtctcattc accagcgccg cccaccgctc aaccaatccc tggccaaaag aatgggaccg     5700

cctggaaggc tggaccaaac aggacctgcc ctctggggct ggggagaggc ccagatgaag     5760

gctgcaggac aggatggact cctagacctc tgttaccagc agtgactacc tctgtctggg     5820

tggttggaac atgtttgaat tttattctaa gtactgtcta caagttctgc aataaacctt     5880

gactcttctt ttaataatgc aaa                                             5903


<210>  17
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  17
atggcccgag ccatggccgc cgcgtggccg ctgctgctgg tggcgctact ggtgctgtcc       60

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gcccggcttc      120

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      180

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      240

acgcagggcc ccagctattc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      300

gcggagctgc ggaatgcctc gctgaggatg ttcgggttgc gcgtagagga tgaaggcaac      360

tacacctgcc tgttcgtcac gttcccgcag ggcagcagga gcgtggatat ctggctccga      420

gtgcttgcca agccccagaa cacagctgag gttcagaagg tccagctcac tggagagcca      480

gtgcccatgg cccgctgcgt ctccacaggg ggtcgcccgc cagcccaaat cacctggcac      540

tcagacctgg gcgggatgcc caatacgagc caggtgccag ggttcctgtc tggcacagtc      600

actgtcacca gcctctggat attggtgccc tcaagccagg tggacggcaa gaatgtgacc      660

tgcaaggtgg agcacgagag ctttgagaag cctcagctgc tgactgtgaa cctcaccgtg      720

tactaccccc cagaggtatc catctctggc tatgataaca actggtacct tggccagaat      780

gaggccaccc tgacctgcga tgctcgcagc aacccagagc ccacaggcta taattggagc      840

acgaccatgg gtcccctgcc accctttgct gtggcccagg gcgcccagct cctgatccgt      900

cctgtggaca aaccaatcaa cacaacttta atctgcaacg tcaccaatgc cctaggagct      960

cgccaggcag aactgaccgt ccaggtcaaa gagggacctc ccagtgagca ctcaggcatg     1020

tcccgtaacg ccatcatctt cctggttctg ggaatcctgg tttttctgat cctgctgggg     1080

atcgggattt atttctattg gtccaaatgt tcccgtgagg tcctttggca ctgtcatctg     1140

tgtccctcga gtacagagca tgccagcgcc tcagctaatg ggcatgtctc ctattcagct     1200

gtgagcagag agaacagctc ttcccaggat ccacagacag agggcacaag gtga           1254


<210>  18
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  19
<211>  5768
<212>  DNA
<213>  Homo sapiens

<400>  19
agcgggactg agcgccggga gagacctgcg caggcgcagg cgcgcgggga gggccagcct       60

gggtggccca ccccgcgcct ggcgggactg gccgccaact cccctccgct ccagtcactt      120

gtctggagct tgaagaagtg ggtattcccc ttcccacccc aggcactgga ggagcggccc      180

cccggggatt ccaggacctg agctccggga gctggactcg cagcgaccgc ggcagagcga      240

gcgggcgccg ggaagcgagg agacgcccgc gggaggccca gctgctcgga gcaactggca      300

tggcccgagc catggccgcc gcgtggccgc tgctgctggt ggcgctactg gtgctgtcct      360

ggccaccccc aggaaccggg gacgtcgtcg tgcaggcgcc cacccaggtg cccggcttct      420

tgggcgactc cgtgacgctg ccctgctacc tacaggtgcc caacatggag gtgacgcatg      480

tgtcacagct gacttgggcg cggcatggtg aatctggcag catggccgtc ttccaccaaa      540

cgcagggccc cagctattcg gagtccaaac ggctggaatt cgtggcagcc agactgggcg      600

cggagctgcg gaatgcctcg ctgaggatgt tcgggttgcg cgtagaggat gaaggcaact      660

acacctgcct gttcgtcacg ttcccgcagg gcagcaggag cgtggatatc tggctccgag      720

tgcttgccaa gccccagaac acagctgagg ttcagaaggt ccagctcact ggagagccag      780

tgcccatggc ccgctgcgtc tccacagggg gtcgcccgcc agcccaaatc acctggcact      840

cagacctggg cgggatgccc aatacgagcc aggtgccagg gttcctgtct ggcacagtca      900

ctgtcaccag cctctggata ttggtgccct caagccaggt ggacggcaag aatgtgacct      960

gcaaggtgga gcacgagagc tttgagaagc ctcagctgct gactgtgaac ctcaccgtgt     1020

actacccccc agaggtatcc atctctggct atgataacaa ctggtacctt ggccagaatg     1080

aggccaccct gacctgcgat gctcgcagca acccagagcc cacaggctat aattggagca     1140

cgaccatggg tcccctgcca ccctttgctg tggcccaggg cgcccagctc ctgatccgtc     1200

ctgtggacaa accaatcaac acaactttaa tctgcaacgt caccaatgcc ctaggagctc     1260

gccaggcaga actgaccgtc caggtcaaag agggacctcc cagtgagcac tcaggtacag     1320

agcatgccag cgcctcagct aatgggcatg tctcctattc agctgtgagc agagagaaca     1380

gctcttccca ggatccacag acagagggca caaggtgaca gcgtcgggac tgagagggga     1440

gagagactgg agctggcaag gacgtgggcc tccagagttg gacccgaccc caatggatga     1500

agaccccctc caaagagacc agcctccctc cctgtgccag acctcaaaac gacgggggca     1560

ggtgcaagtt cataggtctc caagaccacc ctcctttcat ttgctagaag gactcactag     1620

actcaggaaa gctgttaggc tcacagttac agtttattac agtaaaagga cagagattaa     1680

gatcagcaaa gggaggaggt gcacagcaca cgttccacga cagatgaggc gacggcttcc     1740

atctgccctc tcccagtgga gccatatagg cagcacctga ttctcacagc aacatgtgac     1800

aacatgcaag aagtactgcc aatactgcca accagagcag ctcactcgag atctttgtgt     1860

ccagagtttt ttgtttgtct tgagacaggg tctggctctg ttggcagact agagtacagt     1920

ggtgagatca cagttcattg cagccttgac ttctcaacgc caagtcatcc tcccacctca     1980

gcctcctgag tagctatgac tacaggtatg tgccaccacg tctggctaat ctttttatta     2040

tttgtaaagt cgaggtttcc ctgtgttgcc caggctggtc ttgaactctt ggctccaagt     2100

gatacttctg ccttggcctc ccaaagtgct gaattaagca gctcaccatc cacacggctg     2160

acctcataca tcaagccaat accgtgtggc ccaagacccc caccataaat cacatcatta     2220

gcatgaacca cccagagtgg cccaagactc caagatcagc taccaggcag gatattccaa     2280

gggcttagag atgaatgccc aggagctgag gataaagggc ccgatctttc tttgggcaag     2340

gttaagcctt tactgcatag cagaccacac agaagggtgt gggccaccag agaattttgg     2400

taaaaatttg gcctctggcc ttgagcttct aaatctctgt atccgtcaga tctctgtggt     2460

tacaagaaac agccactgac cctggtcacc agaggctgca attcaggccg caagcagctg     2520

cctggggggt gtccaaggag cagagaaaac tactagatgt gaacttgaag aaggttgtca     2580

gctgcagcca ctttctgcca gcatctgcag ccactttctg ccagcatctg cagccagcaa     2640

gctgggactg gcaggaaata acccacaaaa gaagcaaatg caatttccaa cacaaggggg     2700

aagggatgca gggggaggca gcgctgcagt tgctcaggac acgctcctat aggaccaaga     2760

tggatgcgac ccaagaccca ggaggcccag ctgctcagtg caactgacaa gttaaaaagg     2820

tctatgatct tgagggcaga cagcagaatt cctcttataa agaaaactgt ttgggaaaat     2880

acgttgaggg agagaagacc ttgggccaag atgctaaatg ggaatgcaaa gcttgagctg     2940

ctctgcaaga gaaaataagc aggacagagg atttgctctg gacagagatg gaagagccgg     3000

gaacagagaa gtgtggggaa gagataggaa ccagcaggat ggcaggggca aagggctcaa     3060

gggtgaggag gccagtggga ccccacagag ttggggagat aaaggaacat tggttgcttt     3120

ggtggcacgt aagctccttg tctgtctcca gcacccagaa tctcattaaa gcttatttat     3180

tgtacctcca gcggctgtgt gcaatggggt cttttgtgga aatcaaggag cagacaggtt     3240

tcatgtgtac tgtcaccacg tgggatggaa ccagaggcat ggaagcaaga cgctaaatga     3300

agagggccat aagggctggg attcccaggc accttaggaa cagcttgtct tttttttttt     3360

cctctccaaa aaaaatgttt aagggacggt gtctcctgtc acccaggctg gagtgcaatg     3420

gcacgatcat agctcattgc agcctctaac tccggggctc aagcaatcct cccacctcag     3480

cctaccaagt agctgtgacc acagctgccc ctcaccatgc taagctaatt tttttaatta     3540

gatagtacat aaacgtccca aaattagaag ataaaaagac atgagggatc cattctaatt     3600

tgtgtttgga gtgtaatggt ccagctccat tcttctgcac atggatatcc agttttacac     3660

aacactgtga atgtaatgaa tgccactgaa tcatacactc aaaaatagct aaaatggcaa     3720

attgtctgtt atctcttttt aaccaccatt tttgaaaatt aattatacca aaaaaccatt     3780

gaatagtgca ctttatttat ttatttattt gtttatttat ttatttattt tagaaataag     3840

agtctcactt tgttgcccag gctggagtgc agtggcgtga tcatggctca ttgcagcctc     3900

gacctgctgg gctcgggcta tccttccatc tcagcctccc gagtagctgg gactataggt     3960

gggcgccacc ccacctggct aaatctcttt ttaacttttg tagagatagg catctcgcta     4020

tgttgcctag gctgggctgg aactcctggg ctcaagtgct cctcctgcct tggcctccca     4080

aagcgctagg attacagatg tgagccaccg cgcccaccct gaaccttact ttttttgctc     4140

agtttctggt aattcagaga atgcctcctg agttgttcta cacccacctc atattccatg     4200

ggagggctgt acagggcttt tttaacgagg cctctaagga caggcatttg tatcctttcc     4260

agcctttcac tattacaatg ttgtagtgaa taactttaca cactgtcatt tattttactt     4320

tttttttttt ttattttaga gaaaggaatc ttgccatctt gcccaggctg gtctcaaatt     4380

cctgggccca aacaatcctc ccgccttggc ctcctaaagt actgggattt ataggcataa     4440

gccaccgtgc ctggccaatg cacactgtca tttagctcat gttaacacct gagtgtagga     4500

cacactcctg gaggtggaat tgctgggcca aagagtatgt ttcttgtcat tgtgatagat     4560

attgacaaat gaaccctcac agaagttgtg ctgagttctg ttcccaccag cgacgtaggc     4620

gatgaccttt ttctggaggg agggggcatc cttggagtcc acagagccag gaatggagag     4680

tgggcccaga attttggtat aggtgttgta taaacttata gtaaggttaa gaaaaccgca     4740

actatcctta tcagagactt ggcggggggc agggtatgat ggagatcata aggaggctaa     4800

aacactccac accctccctc tgcattgctc ctgcacggga gtcgggaatc ttttcaggtt     4860

gatacgatct caccttgagg agctgtgagg tcccagaagc ctctgggttg cagattgctt     4920

ggggtgaaaa tgtctgtgct actgaaatct aactttttac aaaaaattac gggctgggcg     4980

cagtggctca cgcctgtaat cccagcactt tgggaggctg cagcgggtgg atcacttgag     5040

gtaaggagtt caagaccaga ccatagtgaa accgtgtctc tacaaaaaaa attagccagg     5100

tgtggtggtg catgcttgta atcccagcta ctcagaaggc tgaggtggga gaatcccttg     5160

aacccgggaa gtggaggctg gagtaaacca tgatcgagtt actgcactcc agcctgggtg     5220

acaagagtga gactctgtct ccaaaaaaaa aaaaaaaaaa aaaaaaactg gattgcctgg     5280

ctctactccg ggcacagcat gcaggcccag ttctgctgct ctgctgtttg ttctgctttc     5340

ctccacatat tggcatcacc ctctggtgcc aagatggctg ctgcattcca ggcatcacat     5400

ccagactcag acccagagaa gctgcccatc cctacctggg tgagcctttg taggaacgag     5460

aaaccgcatc cagcagcaga aacctcaccc agcagcgtct tttccggtct cattcaccag     5520

cgccgcccac cgctcaacca atccctggcc aaaagaatgg gaccgcctgg aaggctggac     5580

caaacaggac ctgccctctg gggctgggga gaggcccaga tgaaggctgc aggacaggat     5640

ggactcctag acctctgtta ccagcagtga ctacctctgt ctgggtggtt ggaacatgtt     5700

tgaattttat tctaagtact gtctacaagt tctgcaataa accttgactc ttcttttaat     5760

aatgcaaa                                                              5768


<210>  20
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcccgag ccatggccgc cgcgtggccg ctgctgctgg tggcgctact ggtgctgtcc       60

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gcccggcttc      120

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      180

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      240

acgcagggcc ccagctattc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      300

gcggagctgc ggaatgcctc gctgaggatg ttcgggttgc gcgtagagga tgaaggcaac      360

tacacctgcc tgttcgtcac gttcccgcag ggcagcagga gcgtggatat ctggctccga      420

gtgcttgcca agccccagaa cacagctgag gttcagaagg tccagctcac tggagagcca      480

gtgcccatgg cccgctgcgt ctccacaggg ggtcgcccgc cagcccaaat cacctggcac      540

tcagacctgg gcgggatgcc caatacgagc caggtgccag ggttcctgtc tggcacagtc      600

actgtcacca gcctctggat attggtgccc tcaagccagg tggacggcaa gaatgtgacc      660

tgcaaggtgg agcacgagag ctttgagaag cctcagctgc tgactgtgaa cctcaccgtg      720

tactaccccc cagaggtatc catctctggc tatgataaca actggtacct tggccagaat      780

gaggccaccc tgacctgcga tgctcgcagc aacccagagc ccacaggcta taattggagc      840

acgaccatgg gtcccctgcc accctttgct gtggcccagg gcgcccagct cctgatccgt      900

cctgtggaca aaccaatcaa cacaacttta atctgcaacg tcaccaatgc cctaggagct      960

cgccaggcag aactgaccgt ccaggtcaaa gagggacctc ccagtgagca ctcaggtaca     1020

gagcatgcca gcgcctcagc taatgggcat gtctcctatt cagctgtgag cagagagaac     1080

agctcttccc aggatccaca gacagagggc acaaggtga                            1119


<210>  21
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser 
            340                 345                 350         


Tyr Ser Ala Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr 
        355                 360                 365             


Glu Gly Thr Arg 
    370         


<210>  22
<211>  5744
<212>  DNA
<213>  Homo sapiens

<400>  22
agcgggactg agcgccggga gagacctgcg caggcgcagg cgcgcgggga gggccagcct       60

gggtggccca ccccgcgcct ggcgggactg gccgccaact cccctccgct ccagtcactt      120

gtctggagct tgaagaagtg ggtattcccc ttcccacccc aggcactgga ggagcggccc      180

cccggggatt ccaggacctg agctccggga gctggactcg cagcgaccgc ggcagagcga      240

gcgggcgccg ggaagcgagg agacgcccgc gggaggccca gctgctcgga gcaactggca      300

tggcccgagc catggccgcc gcgtggccgc tgctgctggt ggcgctactg gtgctgtcct      360

ggccaccccc aggaaccggg gacgtcgtcg tgcaggcgcc cacccaggtg cccggcttct      420

tgggcgactc cgtgacgctg ccctgctacc tacaggtgcc caacatggag gtgacgcatg      480

tgtcacagct gacttgggcg cggcatggtg aatctggcag catggccgtc ttccaccaaa      540

cgcagggccc cagctattcg gagtccaaac ggctggaatt cgtggcagcc agactgggcg      600

cggagctgcg gaatgcctcg ctgaggatgt tcgggttgcg cgtagaggat gaaggcaact      660

acacctgcct gttcgtcacg ttcccgcagg gcagcaggag cgtggatatc tggctccgag      720

tgcttgccaa gccccagaac acagctgagg ttcagaaggt ccagctcact ggagagccag      780

tgcccatggc ccgctgcgtc tccacagggg gtcgcccgcc agcccaaatc acctggcact      840

cagacctggg cgggatgccc aatacgagcc aggtgccagg gttcctgtct ggcacagtca      900

ctgtcaccag cctctggata ttggtgccct caagccaggt ggacggcaag aatgtgacct      960

gcaaggtgga gcacgagagc tttgagaagc ctcagctgct gactgtgaac ctcaccgtgt     1020

actacccccc agaggtatcc atctctggct atgataacaa ctggtacctt ggccagaatg     1080

aggccaccct gacctgcgat gctcgcagca acccagagcc cacaggctat aattggagca     1140

cgaccatggg tcccctgcca ccctttgctg tggcccaggg cgcccagctc ctgatccgtc     1200

ctgtggacaa accaatcaac acaactttaa tctgcaacgt caccaatgcc ctaggagctc     1260

gccaggcaga actgaccgtc caggtcaaag gtacagagca tgccagcgcc tcagctaatg     1320

ggcatgtctc ctattcagct gtgagcagag agaacagctc ttcccaggat ccacagacag     1380

agggcacaag gtgacagcgt cgggactgag aggggagaga gactggagct ggcaaggacg     1440

tgggcctcca gagttggacc cgaccccaat ggatgaagac cccctccaaa gagaccagcc     1500

tccctccctg tgccagacct caaaacgacg ggggcaggtg caagttcata ggtctccaag     1560

accaccctcc tttcatttgc tagaaggact cactagactc aggaaagctg ttaggctcac     1620

agttacagtt tattacagta aaaggacaga gattaagatc agcaaaggga ggaggtgcac     1680

agcacacgtt ccacgacaga tgaggcgacg gcttccatct gccctctccc agtggagcca     1740

tataggcagc acctgattct cacagcaaca tgtgacaaca tgcaagaagt actgccaata     1800

ctgccaacca gagcagctca ctcgagatct ttgtgtccag agttttttgt ttgtcttgag     1860

acagggtctg gctctgttgg cagactagag tacagtggtg agatcacagt tcattgcagc     1920

cttgacttct caacgccaag tcatcctccc acctcagcct cctgagtagc tatgactaca     1980

ggtatgtgcc accacgtctg gctaatcttt ttattatttg taaagtcgag gtttccctgt     2040

gttgcccagg ctggtcttga actcttggct ccaagtgata cttctgcctt ggcctcccaa     2100

agtgctgaat taagcagctc accatccaca cggctgacct catacatcaa gccaataccg     2160

tgtggcccaa gacccccacc ataaatcaca tcattagcat gaaccaccca gagtggccca     2220

agactccaag atcagctacc aggcaggata ttccaagggc ttagagatga atgcccagga     2280

gctgaggata aagggcccga tctttctttg ggcaaggtta agcctttact gcatagcaga     2340

ccacacagaa gggtgtgggc caccagagaa ttttggtaaa aatttggcct ctggccttga     2400

gcttctaaat ctctgtatcc gtcagatctc tgtggttaca agaaacagcc actgaccctg     2460

gtcaccagag gctgcaattc aggccgcaag cagctgcctg gggggtgtcc aaggagcaga     2520

gaaaactact agatgtgaac ttgaagaagg ttgtcagctg cagccacttt ctgccagcat     2580

ctgcagccac tttctgccag catctgcagc cagcaagctg ggactggcag gaaataaccc     2640

acaaaagaag caaatgcaat ttccaacaca agggggaagg gatgcagggg gaggcagcgc     2700

tgcagttgct caggacacgc tcctatagga ccaagatgga tgcgacccaa gacccaggag     2760

gcccagctgc tcagtgcaac tgacaagtta aaaaggtcta tgatcttgag ggcagacagc     2820

agaattcctc ttataaagaa aactgtttgg gaaaatacgt tgagggagag aagaccttgg     2880

gccaagatgc taaatgggaa tgcaaagctt gagctgctct gcaagagaaa ataagcagga     2940

cagaggattt gctctggaca gagatggaag agccgggaac agagaagtgt ggggaagaga     3000

taggaaccag caggatggca ggggcaaagg gctcaagggt gaggaggcca gtgggacccc     3060

acagagttgg ggagataaag gaacattggt tgctttggtg gcacgtaagc tccttgtctg     3120

tctccagcac ccagaatctc attaaagctt atttattgta cctccagcgg ctgtgtgcaa     3180

tggggtcttt tgtggaaatc aaggagcaga caggtttcat gtgtactgtc accacgtggg     3240

atggaaccag aggcatggaa gcaagacgct aaatgaagag ggccataagg gctgggattc     3300

ccaggcacct taggaacagc ttgtcttttt ttttttcctc tccaaaaaaa atgtttaagg     3360

gacggtgtct cctgtcaccc aggctggagt gcaatggcac gatcatagct cattgcagcc     3420

tctaactccg gggctcaagc aatcctccca cctcagccta ccaagtagct gtgaccacag     3480

ctgcccctca ccatgctaag ctaatttttt taattagata gtacataaac gtcccaaaat     3540

tagaagataa aaagacatga gggatccatt ctaatttgtg tttggagtgt aatggtccag     3600

ctccattctt ctgcacatgg atatccagtt ttacacaaca ctgtgaatgt aatgaatgcc     3660

actgaatcat acactcaaaa atagctaaaa tggcaaattg tctgttatct ctttttaacc     3720

accatttttg aaaattaatt ataccaaaaa accattgaat agtgcacttt atttatttat     3780

ttatttgttt atttatttat ttattttaga aataagagtc tcactttgtt gcccaggctg     3840

gagtgcagtg gcgtgatcat ggctcattgc agcctcgacc tgctgggctc gggctatcct     3900

tccatctcag cctcccgagt agctgggact ataggtgggc gccaccccac ctggctaaat     3960

ctctttttaa cttttgtaga gataggcatc tcgctatgtt gcctaggctg ggctggaact     4020

cctgggctca agtgctcctc ctgccttggc ctcccaaagc gctaggatta cagatgtgag     4080

ccaccgcgcc caccctgaac cttacttttt ttgctcagtt tctggtaatt cagagaatgc     4140

ctcctgagtt gttctacacc cacctcatat tccatgggag ggctgtacag ggctttttta     4200

acgaggcctc taaggacagg catttgtatc ctttccagcc tttcactatt acaatgttgt     4260

agtgaataac tttacacact gtcatttatt ttactttttt ttttttttat tttagagaaa     4320

ggaatcttgc catcttgccc aggctggtct caaattcctg ggcccaaaca atcctcccgc     4380

cttggcctcc taaagtactg ggatttatag gcataagcca ccgtgcctgg ccaatgcaca     4440

ctgtcattta gctcatgtta acacctgagt gtaggacaca ctcctggagg tggaattgct     4500

gggccaaaga gtatgtttct tgtcattgtg atagatattg acaaatgaac cctcacagaa     4560

gttgtgctga gttctgttcc caccagcgac gtaggcgatg acctttttct ggagggaggg     4620

ggcatccttg gagtccacag agccaggaat ggagagtggg cccagaattt tggtataggt     4680

gttgtataaa cttatagtaa ggttaagaaa accgcaacta tccttatcag agacttggcg     4740

gggggcaggg tatgatggag atcataagga ggctaaaaca ctccacaccc tccctctgca     4800

ttgctcctgc acgggagtcg ggaatctttt caggttgata cgatctcacc ttgaggagct     4860

gtgaggtccc agaagcctct gggttgcaga ttgcttgggg tgaaaatgtc tgtgctactg     4920

aaatctaact ttttacaaaa aattacgggc tgggcgcagt ggctcacgcc tgtaatccca     4980

gcactttggg aggctgcagc gggtggatca cttgaggtaa ggagttcaag accagaccat     5040

agtgaaaccg tgtctctaca aaaaaaatta gccaggtgtg gtggtgcatg cttgtaatcc     5100

cagctactca gaaggctgag gtgggagaat cccttgaacc cgggaagtgg aggctggagt     5160

aaaccatgat cgagttactg cactccagcc tgggtgacaa gagtgagact ctgtctccaa     5220

aaaaaaaaaa aaaaaaaaaa aaactggatt gcctggctct actccgggca cagcatgcag     5280

gcccagttct gctgctctgc tgtttgttct gctttcctcc acatattggc atcaccctct     5340

ggtgccaaga tggctgctgc attccaggca tcacatccag actcagaccc agagaagctg     5400

cccatcccta cctgggtgag cctttgtagg aacgagaaac cgcatccagc agcagaaacc     5460

tcacccagca gcgtcttttc cggtctcatt caccagcgcc gcccaccgct caaccaatcc     5520

ctggccaaaa gaatgggacc gcctggaagg ctggaccaaa caggacctgc cctctggggc     5580

tggggagagg cccagatgaa ggctgcagga caggatggac tcctagacct ctgttaccag     5640

cagtgactac ctctgtctgg gtggttggaa catgtttgaa ttttattcta agtactgtct     5700

acaagttctg caataaacct tgactcttct tttaataatg caaa                      5744


<210>  23
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcccgag ccatggccgc cgcgtggccg ctgctgctgg tggcgctact ggtgctgtcc       60

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gcccggcttc      120

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      180

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      240

acgcagggcc ccagctattc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      300

gcggagctgc ggaatgcctc gctgaggatg ttcgggttgc gcgtagagga tgaaggcaac      360

tacacctgcc tgttcgtcac gttcccgcag ggcagcagga gcgtggatat ctggctccga      420

gtgcttgcca agccccagaa cacagctgag gttcagaagg tccagctcac tggagagcca      480

gtgcccatgg cccgctgcgt ctccacaggg ggtcgcccgc cagcccaaat cacctggcac      540

tcagacctgg gcgggatgcc caatacgagc caggtgccag ggttcctgtc tggcacagtc      600

actgtcacca gcctctggat attggtgccc tcaagccagg tggacggcaa gaatgtgacc      660

tgcaaggtgg agcacgagag ctttgagaag cctcagctgc tgactgtgaa cctcaccgtg      720

tactaccccc cagaggtatc catctctggc tatgataaca actggtacct tggccagaat      780

gaggccaccc tgacctgcga tgctcgcagc aacccagagc ccacaggcta taattggagc      840

acgaccatgg gtcccctgcc accctttgct gtggcccagg gcgcccagct cctgatccgt      900

cctgtggaca aaccaatcaa cacaacttta atctgcaacg tcaccaatgc cctaggagct      960

cgccaggcag aactgaccgt ccaggtcaaa ggtacagagc atgccagcgc ctcagctaat     1020

gggcatgtct cctattcagc tgtgagcaga gagaacagct cttcccagga tccacagaca     1080

gagggcacaa ggtga                                                      1095


<210>  24
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Gly Thr Glu His Ala Ser 
                325                 330                 335     


Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu Asn 
            340                 345                 350         


Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg 
        355                 360                 


<210>  25
<211>  1643
<212>  DNA
<213>  Homo sapiens

<400>  25
agcgggactg agcgccggga gagacctgcg caggcgcagg cgcgcgggga gggccagcct       60

gggtggccca ccccgcgcct ggcgggactg gccgccaact cccctccgct ccagtcactt      120

gtctggagct tgaagaagtg ggtattcccc ttcccacccc aggcactgga ggagcggccc      180

cccggggatt ccaggacctg agctccggga gctggactcg cagcgaccgc ggcagagcga      240

gcgggcgccg ggaagcgagg agacgcccgc gggaggccca gctgctcgga gcaactggca      300

tggcccgagc catggccgcc gcgtggccgc tgctgctggt ggcgctactg gtgctgtcct      360

ggccaccccc aggaaccggg gacgtcgtcg tgcaggcgcc cacccaggtg cccggcttct      420

tgggcgactc cgtgacgctg ccctgctacc tacaggtgcc caacatggag gtgacgcatg      480

tgtcacagct gacttgggcg cggcatggtg aatctggcag catggccgtc ttccaccaaa      540

cgcagggccc cagctattcg gagtccaaac ggctggaatt cgtggcagcc agactgggcg      600

cggagctgcg gaatgcctcg ctgaggatgt tcgggttgcg cgtagaggat gaaggcaact      660

acacctgcct gttcgtcacg ttcccgcagg gcagcaggag cgtggatatc tggctccgag      720

tgcttgccaa gccccagaac acagctgagg ttcagaaggt ccagctcact ggagagccag      780

tgcccatggc ccgctgcgtc tccacagggg gtcgcccgcc agcccaaatc acctggcact      840

cagacctggg cgggatgccc aatacgagcc aggtgccagg gttcctgtct ggcacagtca      900

ctgtcaccag cctctggata ttggtgccct caagccaggt ggacggcaag aatgtgacct      960

gcaaggtgga gcacgagagc tttgagaagc ctcagctgct gactgtgaac ctcaccgtgt     1020

actacccccc agaggtatcc atctctggct atgataacaa ctggtacctt ggccagaatg     1080

aggccaccct gacctgcgat gctcgcagca acccagagcc cacaggctat aattggagca     1140

cgaccatggg tcccctgcca ccctttgctg tggcccaggg cgcccagctc ctgatccgtc     1200

ctgtggacaa accaatcaac acaactttaa tctgcaacgt caccaatgcc ctaggagctc     1260

gccaggcaga actgaccgtc caggtcaaag agggacctcc cagtgagcac tcaggcatgt     1320

cccgtaacgc catcatcttc ctggttctgg gaatcctggt ttttctgatc ctgctgggga     1380

tcgggattta tttctattgg tccaaatgtt cccgtgaggt cctttggcac tgtcatctgt     1440

gtccctcgag tgagcatcac cagagctgcc gtaattgagc acctactacg ggctctgtgc     1500

tgagtccttc cagtgtgcct ctcactgaat cctcacccca ctgccatgag gtttccccca     1560

tttgactgat gagggtgcag agccagggag ccttgttcac tggttcattg attacattta     1620

caaatattat ttacagagtg gga                                             1643


<210>  26
<211>  1179
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcccgag ccatggccgc cgcgtggccg ctgctgctgg tggcgctact ggtgctgtcc       60

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gcccggcttc      120

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      180

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      240

acgcagggcc ccagctattc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      300

gcggagctgc ggaatgcctc gctgaggatg ttcgggttgc gcgtagagga tgaaggcaac      360

tacacctgcc tgttcgtcac gttcccgcag ggcagcagga gcgtggatat ctggctccga      420

gtgcttgcca agccccagaa cacagctgag gttcagaagg tccagctcac tggagagcca      480

gtgcccatgg cccgctgcgt ctccacaggg ggtcgcccgc cagcccaaat cacctggcac      540

tcagacctgg gcgggatgcc caatacgagc caggtgccag ggttcctgtc tggcacagtc      600

actgtcacca gcctctggat attggtgccc tcaagccagg tggacggcaa gaatgtgacc      660

tgcaaggtgg agcacgagag ctttgagaag cctcagctgc tgactgtgaa cctcaccgtg      720

tactaccccc cagaggtatc catctctggc tatgataaca actggtacct tggccagaat      780

gaggccaccc tgacctgcga tgctcgcagc aacccagagc ccacaggcta taattggagc      840

acgaccatgg gtcccctgcc accctttgct gtggcccagg gcgcccagct cctgatccgt      900

cctgtggaca aaccaatcaa cacaacttta atctgcaacg tcaccaatgc cctaggagct      960

cgccaggcag aactgaccgt ccaggtcaaa gagggacctc ccagtgagca ctcaggcatg     1020

tcccgtaacg ccatcatctt cctggttctg ggaatcctgg tttttctgat cctgctgggg     1080

atcgggattt atttctattg gtccaaatgt tcccgtgagg tcctttggca ctgtcatctg     1140

tgtccctcga gtgagcatca ccagagctgc cgtaattga                            1179


<210>  27
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Glu His His Gln Ser Cys Arg Asn 
385                 390         


<210>  28
<211>  2844
<212>  DNA
<213>  Homo sapiens

<400>  28
tagaacaaag gagaagtgcg tcctttcaaa ttatagattc tttgggggaa aagagggaca       60

gaactttatc tgagtttgga atgagtctga gtagctgcaa tagtaaagtt gcttccagaa      120

gcaggtaaac ttgacttcaa aaaaccccgc ttcatgaaat attagtgatt cacttcagtt      180

gctatctgag gaagttctgg tagagagaag agctcaagag catgggcaga gtcagctcct      240

gagtgggctg aacgctcccc tcagctcctg cagtgctaat taagggaggg agcagcgggg      300

agcttgcagt gaccaagagg gtgttgaggc taggaggcca cgataaacag gatacgataa      360

aagtccttaa ccaagacgca gatgggaaga agcgttagag cgagcagcac tcacatctca      420

agaaccagcc tttcaaacag tttccagaga tggattatcc tactttactt ttggctcttc      480

ttcatgtata cagagctcta tgtgaagagg tgctttggca tacatcagtt ccctttgccg      540

agaacatgtc tctagaatgt gtgtatccat caatgggcat cttaacacag gtggagtggt      600

tcaagatcgg gacccagcag gattccatag ccattttcag ccctactcat ggcatggtca      660

taaggaagcc ctatgctgag agggtttact ttttgaattc aacgatggct tccaataaca      720

tgactctttt ctttcggaat gcctctgaag atgatgttgg ctactattcc tgctctcttt      780

acacttaccc acagggaact tggcagaagg tgatacaggt ggttcagtca gatagttttg      840

aggcagctgt gccatcaaat agccacattg tttcggaacc tggaaagaat gtcacactca      900

cttgtcagcc tcagatgacg tggcctgtgc aggcagtgag gtgggaaaag atccagcccc      960

gtcagatcga cctcttaact tactgcaact tggtccatgg cagaaatttc acctccaagt     1020

tcccaagaca aatagtgagc aactgcagcc acggaaggtg gagcgtcatc gtcatccccg     1080

atgtcacagt ctcagactcg gggctttacc gctgctactt gcaggccagc gcaggagaaa     1140

acgaaacctt cgtgatgaga ttgactgtag ccgagggtaa aaccgataac caatataccc     1200

tctttgtggc tggagggaca gttttattgt tgttgtttgt tatctcaatt accaccatca     1260

ttgtcatttt ccttaacaga aggagaagga gagagagaag agatctattt acagagtcct     1320

gggatacaca gaaggcaccc aataactata gaagtcccat ctctaccagt caacctacca     1380

atcaatccat ggatgataca agagaggata tttatgtcaa ctatccaacc ttctctcgca     1440

gaccaaagac tagagtttaa gcttattctt gacatgagtg cattagtaat gactcttatg     1500

tactcatgca tggatcttta tgcaattttt ttccactacc caaggtctac cttagatact     1560

agttgtctga attgagttac tttgatagga aaaatacttc attacctaaa atcatttttc     1620

atagaactgt ttcagaaaac ctgactctaa ctggtttata tacaaaagaa aacttactgt     1680

atcatataac agaatgatcc aggggagatt aagctttggg caagggctat ttaccagggc     1740

ttaaatgttg tgtctagaat taagtatggg cataaactgg cttctgaatc cctttccaga     1800

gtgttggatc catttccctg gtcttggcct cactctcatg caggctttcc tcttgtgttg     1860

gcaagatggc tgccaactct tggcaattca tacatccttg tttctgtctg gtagagagtt     1920

tgcttctcaa atggagcaaa caaatttgat tattttttca ttgttaaata ggcaacatga     1980

ccagaaagga tggaatggct taagtaaact aagggttcac ttctagagct gagaagcagg     2040

gtcaaagcac aatactgggc aattcagagc atggttagaa gaggaaaggg gagtctcaaa     2100

gctggagagt ttaccaacaa atattgactg cagtgattaa ccaagacatt tttgttaact     2160

aaaaagtgaa atatgggatg gattctagaa atggggtatc tctgtccata cttctagaat     2220

ccactctatc agcatagtcc agaagaatac ctggcagtag aagaaatgaa tattcaagag     2280

gaagataaat gcgagagggc aatcctttac tattctcata tttatttatc tctcattctg     2340

tatagaattc ttgccgccat cccaggtcta gccttaggag caaatgtagt agatagtcga     2400

ataataaata acttaatgtt ttggacatat tttgtctact tttgagaatt atttttaata     2460

tgtaaattct ctcaaaaggg tcaggcacct agttattatt ttttaatgat tatgtgaaag     2520

ttgaatataa tataccacta aaagtgacag ttgaaagtgg tggcatagga cggtagggta     2580

gaaatttggg agggaaaaaa gaaattggga gggtacaggc aacaggagaa aggaatcaaa     2640

ccacagaaaa atacaaaggg aaacttctgc ttcactattc agacaaagac agccctaatg     2700

acatcaccaa cagtcaaagc aattagagac catacctaat attgtttaaa ttctagatgt     2760

aggctaacaa tgaaaagtat ttgccaaact gaataaaact gtcatggtta ccttgaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaa                                            2844


<210>  29
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  29
atggattatc ctactttact tttggctctt cttcatgtat acagagctct atgtgaagag       60

gtgctttggc atacatcagt tccctttgcc gagaacatgt ctctagaatg tgtgtatcca      120

tcaatgggca tcttaacaca ggtggagtgg ttcaagatcg ggacccagca ggattccata      180

gccattttca gccctactca tggcatggtc ataaggaagc cctatgctga gagggtttac      240

tttttgaatt caacgatggc ttccaataac atgactcttt tctttcggaa tgcctctgaa      300

gatgatgttg gctactattc ctgctctctt tacacttacc cacagggaac ttggcagaag      360

gtgatacagg tggttcagtc agatagtttt gaggcagctg tgccatcaaa tagccacatt      420

gtttcggaac ctggaaagaa tgtcacactc acttgtcagc ctcagatgac gtggcctgtg      480

caggcagtga ggtgggaaaa gatccagccc cgtcagatcg acctcttaac ttactgcaac      540

ttggtccatg gcagaaattt cacctccaag ttcccaagac aaatagtgag caactgcagc      600

cacggaaggt ggagcgtcat cgtcatcccc gatgtcacag tctcagactc ggggctttac      660

cgctgctact tgcaggccag cgcaggagaa aacgaaacct tcgtgatgag attgactgta      720

gccgagggta aaaccgataa ccaatatacc ctctttgtgg ctggagggac agttttattg      780

ttgttgtttg ttatctcaat taccaccatc attgtcattt tccttaacag aaggagaagg      840

agagagagaa gagatctatt tacagagtcc tgggatacac agaaggcacc caataactat      900

agaagtccca tctctaccag tcaacctacc aatcaatcca tggatgatac aagagaggat      960

atttatgtca actatccaac cttctctcgc agaccaaaga ctagagttta a              1011


<210>  30
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  31
<211>  2842
<212>  DNA
<213>  Homo sapiens

<400>  31
atgcatgcac cacctttcac ttattattta tatttttaca tctttatttt agtttctgcc       60

tcctccacat agaatgtaag ttctatcatg gcaatatttt tttttttttg tattattgta      120

tcctcattgc ctacagctga gttaggcaca gagaatgcat gcagcacatg tttgttgaat      180

gaatgactcc ttgtagaaaa tgaaagcccg aaaataagcc gactggttcc ccgagagaga      240

agaaactcaa atctgcccat cctcataaag gagcaaacct gtcttttaag ctaaggcctt      300

tttcctgtgt tcatacttca gaaaaagaag acacgactga taacatctga gaggaaggaa      360

actgcattgt gctggggatc tgcatgtcac attataaaaa gcaatttttt tttttaatag      420

aaccagcctt tcaaacagtt tccagagatg gattatccta ctttactttt ggctcttctt      480

catgtataca gagctctatg tgaagaggtg ctttggcata catcagttcc ctttgccgag      540

aacatgtctc tagaatgtgt gtatccatca atgggcatct taacacaggt ggagtggttc      600

aagatcggga cccagcagga ttccatagcc attttcagcc ctactcatgg catggtcata      660

aggaagccct atgctgagag ggtttacttt ttgaattcaa cgatggcttc caataacatg      720

actcttttct ttcggaatgc ctctgaagat gatgttggct actattcctg ctctctttac      780

acttacccac agggaacttg gcagaaggtg atacaggtgg ttcagtcaga tagttttgag      840

gcagctgtgc catcaaatag ccacattgtt tcggaacctg gaaagaatgt cacactcact      900

tgtcagcctc agatgacgtg gcctgtgcag gcagtgaggt gggaaaagat ccagccccgt      960

cagatcgacc tcttaactta ctgcaacttg gtccatggca gaaatttcac ctccaagttc     1020

ccaagacaaa tagtgagcaa ctgcagccac ggaaggtgga gcgtcatcgt catccccgat     1080

gtcacagtct cagactcggg gctttaccgc tgctacttgc aggccagcgc aggagaaaac     1140

gaaaccttcg tgatgagatt gactgtagcc gagggtaaaa ccgataacca atataccctc     1200

tttgtggctg gagggacagt tttattgttg ttgtttgtta tctcaattac caccatcatt     1260

gtcattttcc ttaacagaag gagaaggaga gagagaagag atctatttac agagtcctgg     1320

gatacacaga aggcacccaa taactataga agtcccatct ctaccagtca acctaccaat     1380

caatccatgg atgatacaag agaggatatt tatgtcaact atccaacctt ctctcgcaga     1440

ccaaagacta gagtttaagc ttattcttga catgagtgca ttagtaatga ctcttatgta     1500

ctcatgcatg gatctttatg caattttttt ccactaccca aggtctacct tagatactag     1560

ttgtctgaat tgagttactt tgataggaaa aatacttcat tacctaaaat catttttcat     1620

agaactgttt cagaaaacct gactctaact ggtttatata caaaagaaaa cttactgtat     1680

catataacag aatgatccag gggagattaa gctttgggca agggctattt accagggctt     1740

aaatgttgtg tctagaatta agtatgggca taaactggct tctgaatccc tttccagagt     1800

gttggatcca tttccctggt cttggcctca ctctcatgca ggctttcctc ttgtgttggc     1860

aagatggctg ccaactcttg gcaattcata catccttgtt tctgtctggt agagagtttg     1920

cttctcaaat ggagcaaaca aatttgatta ttttttcatt gttaaatagg caacatgacc     1980

agaaaggatg gaatggctta agtaaactaa gggttcactt ctagagctga gaagcagggt     2040

caaagcacaa tactgggcaa ttcagagcat ggttagaaga ggaaagggga gtctcaaagc     2100

tggagagttt accaacaaat attgactgca gtgattaacc aagacatttt tgttaactaa     2160

aaagtgaaat atgggatgga ttctagaaat ggggtatctc tgtccatact tctagaatcc     2220

actctatcag catagtccag aagaatacct ggcagtagaa gaaatgaata ttcaagagga     2280

agataaatgc gagagggcaa tcctttacta ttctcatatt tatttatctc tcattctgta     2340

tagaattctt gccgccatcc caggtctagc cttaggagca aatgtagtag atagtcgaat     2400

aataaataac ttaatgtttt ggacatattt tgtctacttt tgagaattat ttttaatatg     2460

taaattctct caaaagggtc aggcacctag ttattatttt ttaatgatta tgtgaaagtt     2520

gaatataata taccactaaa agtgacagtt gaaagtggtg gcataggacg gtagggtaga     2580

aatttgggag ggaaaaaaga aattgggagg gtacaggcaa caggagaaag gaatcaaacc     2640

acagaaaaat acaaagggaa acttctgctt cactattcag acaaagacag ccctaatgac     2700

atcaccaaca gtcaaagcaa ttagagacca tacctaatat tgtttaaatt ctagatgtag     2760

gctaacaatg aaaagtattt gccaaactga ataaaactgt catggttacc ttgaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aa                                              2842


<210>  32
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  32
atggattatc ctactttact tttggctctt cttcatgtat acagagctct atgtgaagag       60

gtgctttggc atacatcagt tccctttgcc gagaacatgt ctctagaatg tgtgtatcca      120

tcaatgggca tcttaacaca ggtggagtgg ttcaagatcg ggacccagca ggattccata      180

gccattttca gccctactca tggcatggtc ataaggaagc cctatgctga gagggtttac      240

tttttgaatt caacgatggc ttccaataac atgactcttt tctttcggaa tgcctctgaa      300

gatgatgttg gctactattc ctgctctctt tacacttacc cacagggaac ttggcagaag      360

gtgatacagg tggttcagtc agatagtttt gaggcagctg tgccatcaaa tagccacatt      420

gtttcggaac ctggaaagaa tgtcacactc acttgtcagc ctcagatgac gtggcctgtg      480

caggcagtga ggtgggaaaa gatccagccc cgtcagatcg acctcttaac ttactgcaac      540

ttggtccatg gcagaaattt cacctccaag ttcccaagac aaatagtgag caactgcagc      600

cacggaaggt ggagcgtcat cgtcatcccc gatgtcacag tctcagactc ggggctttac      660

cgctgctact tgcaggccag cgcaggagaa aacgaaacct tcgtgatgag attgactgta      720

gccgagggta aaaccgataa ccaatatacc ctctttgtgg ctggagggac agttttattg      780

ttgttgtttg ttatctcaat taccaccatc attgtcattt tccttaacag aaggagaagg      840

agagagagaa gagatctatt tacagagtcc tgggatacac agaaggcacc caataactat      900

agaagtccca tctctaccag tcaacctacc aatcaatcca tggatgatac aagagaggat      960

atttatgtca actatccaac cttctctcgc agaccaaaga ctagagttta a              1011


<210>  33
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  34
<211>  2435
<212>  DNA
<213>  Homo sapiens

<400>  34
tagaacaaag gagaagtgcg tcctttcaaa ttatagattc tttgggggaa aagagggaca       60

gaactttatc tgagtttgga atgagtctga gtagctgcaa tagtaaagtt gcttccagaa      120

gcaggtaaac ttgacttcaa aaaaccccgc ttcatgaaat attagtgatt cacttcagtt      180

gctatctgag gaagttctgg tagagagaag agctcaagag catgggcaga gtcagctcct      240

gagtgggctg aacgctcccc tcagctcctg cagtgctaat taagggaggg agcagcgggg      300

agcttgcagt gaccaagagg gtgttgaggc taggaggcca cgataaacag gatacgataa      360

aagtccttaa ccaagacgca gatgggaaga agcgttagag cgagcagcac tcacatctca      420

agatagtttt gaggcagctg tgccatcaaa tagccacatt gtttcggaac ctggaaagaa      480

tgtcacactc acttgtcagc ctcagatgac gtggcctgtg caggcagtga ggtgggaaaa      540

gatccagccc cgtcagatcg acctcttaac ttactgcaac ttggtccatg gcagaaattt      600

cacctccaag ttcccaagac aaatagtgag caactgcagc cacggaaggt ggagcgtcat      660

cgtcatcccc gatgtcacag tctcagactc ggggctttac cgctgctact tgcaggccag      720

cgcaggagaa aacgaaacct tcgtgatgag attgactgta gccgagggta aaaccgataa      780

ccaatatacc ctctttgtgg ctggagggac agttttattg ttgttgtttg ttatctcaat      840

taccaccatc attgtcattt tccttaacag aaggagaagg agagagagaa gagatctatt      900

tacagagtcc tgggatacac agaaggcacc caataactat agaagtccca tctctaccag      960

tcaacctacc aatcaatcca tggatgatac aagagaggat atttatgtca actatccaac     1020

cttctctcgc agaccaaaga ctagagttta agcttattct tgacatgagt gcattagtaa     1080

tgactcttat gtactcatgc atggatcttt atgcaatttt tttccactac ccaaggtcta     1140

ccttagatac tagttgtctg aattgagtta ctttgatagg aaaaatactt cattacctaa     1200

aatcattttt catagaactg tttcagaaaa cctgactcta actggtttat atacaaaaga     1260

aaacttactg tatcatataa cagaatgatc caggggagat taagctttgg gcaagggcta     1320

tttaccaggg cttaaatgtt gtgtctagaa ttaagtatgg gcataaactg gcttctgaat     1380

ccctttccag agtgttggat ccatttccct ggtcttggcc tcactctcat gcaggctttc     1440

ctcttgtgtt ggcaagatgg ctgccaactc ttggcaattc atacatcctt gtttctgtct     1500

ggtagagagt ttgcttctca aatggagcaa acaaatttga ttattttttc attgttaaat     1560

aggcaacatg accagaaagg atggaatggc ttaagtaaac taagggttca cttctagagc     1620

tgagaagcag ggtcaaagca caatactggg caattcagag catggttaga agaggaaagg     1680

ggagtctcaa agctggagag tttaccaaca aatattgact gcagtgatta accaagacat     1740

ttttgttaac taaaaagtga aatatgggat ggattctaga aatggggtat ctctgtccat     1800

acttctagaa tccactctat cagcatagtc cagaagaata cctggcagta gaagaaatga     1860

atattcaaga ggaagataaa tgcgagaggg caatccttta ctattctcat atttatttat     1920

ctctcattct gtatagaatt cttgccgcca tcccaggtct agccttagga gcaaatgtag     1980

tagatagtcg aataataaat aacttaatgt tttggacata ttttgtctac ttttgagaat     2040

tatttttaat atgtaaattc tctcaaaagg gtcaggcacc tagttattat tttttaatga     2100

ttatgtgaaa gttgaatata atataccact aaaagtgaca gttgaaagtg gtggcatagg     2160

acggtagggt agaaatttgg gagggaaaaa agaaattggg agggtacagg caacaggaga     2220

aaggaatcaa accacagaaa aatacaaagg gaaacttctg cttcactatt cagacaaaga     2280

cagccctaat gacatcacca acagtcaaag caattagaga ccatacctaa tattgtttaa     2340

attctagatg taggctaaca atgaaaagta tttgccaaac tgaataaaac tgtcatggtt     2400

accttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                2435


<210>  35
<211>  2435
<212>  DNA
<213>  Homo sapiens

<400>  35
tagaacaaag gagaagtgcg tcctttcaaa ttatagattc tttgggggaa aagagggaca       60

gaactttatc tgagtttgga atgagtctga gtagctgcaa tagtaaagtt gcttccagaa      120

gcaggtaaac ttgacttcaa aaaaccccgc ttcatgaaat attagtgatt cacttcagtt      180

gctatctgag gaagttctgg tagagagaag agctcaagag catgggcaga gtcagctcct      240

gagtgggctg aacgctcccc tcagctcctg cagtgctaat taagggaggg agcagcgggg      300

agcttgcagt gaccaagagg gtgttgaggc taggaggcca cgataaacag gatacgataa      360

aagtccttaa ccaagacgca gatgggaaga agcgttagag cgagcagcac tcacatctca      420

agatagtttt gaggcagctg tgccatcaaa tagccacatt gtttcggaac ctggaaagaa      480

tgtcacactc acttgtcagc ctcagatgac gtggcctgtg caggcagtga ggtgggaaaa      540

gatccagccc cgtcagatcg acctcttaac ttactgcaac ttggtccatg gcagaaattt      600

cacctccaag ttcccaagac aaatagtgag caactgcagc cacggaaggt ggagcgtcat      660

cgtcatcccc gatgtcacag tctcagactc ggggctttac cgctgctact tgcaggccag      720

cgcaggagaa aacgaaacct tcgtgatgag attgactgta gccgagggta aaaccgataa      780

ccaatatacc ctctttgtgg ctggagggac agttttattg ttgttgtttg ttatctcaat      840

taccaccatc attgtcattt tccttaacag aaggagaagg agagagagaa gagatctatt      900

tacagagtcc tgggatacac agaaggcacc caataactat agaagtccca tctctaccag      960

tcaacctacc aatcaatcca tggatgatac aagagaggat atttatgtca actatccaac     1020

cttctctcgc agaccaaaga ctagagttta agcttattct tgacatgagt gcattagtaa     1080

tgactcttat gtactcatgc atggatcttt atgcaatttt tttccactac ccaaggtcta     1140

ccttagatac tagttgtctg aattgagtta ctttgatagg aaaaatactt cattacctaa     1200

aatcattttt catagaactg tttcagaaaa cctgactcta actggtttat atacaaaaga     1260

aaacttactg tatcatataa cagaatgatc caggggagat taagctttgg gcaagggcta     1320

tttaccaggg cttaaatgtt gtgtctagaa ttaagtatgg gcataaactg gcttctgaat     1380

ccctttccag agtgttggat ccatttccct ggtcttggcc tcactctcat gcaggctttc     1440

ctcttgtgtt ggcaagatgg ctgccaactc ttggcaattc atacatcctt gtttctgtct     1500

ggtagagagt ttgcttctca aatggagcaa acaaatttga ttattttttc attgttaaat     1560

aggcaacatg accagaaagg atggaatggc ttaagtaaac taagggttca cttctagagc     1620

tgagaagcag ggtcaaagca caatactggg caattcagag catggttaga agaggaaagg     1680

ggagtctcaa agctggagag tttaccaaca aatattgact gcagtgatta accaagacat     1740

ttttgttaac taaaaagtga aatatgggat ggattctaga aatggggtat ctctgtccat     1800

acttctagaa tccactctat cagcatagtc cagaagaata cctggcagta gaagaaatga     1860

atattcaaga ggaagataaa tgcgagaggg caatccttta ctattctcat atttatttat     1920

ctctcattct gtatagaatt cttgccgcca tcccaggtct agccttagga gcaaatgtag     1980

tagatagtcg aataataaat aacttaatgt tttggacata ttttgtctac ttttgagaat     2040

tatttttaat atgtaaattc tctcaaaagg gtcaggcacc tagttattat tttttaatga     2100

ttatgtgaaa gttgaatata atataccact aaaagtgaca gttgaaagtg gtggcatagg     2160

acggtagggt agaaatttgg gagggaaaaa agaaattggg agggtacagg caacaggaga     2220

aaggaatcaa accacagaaa aatacaaagg gaaacttctg cttcactatt cagacaaaga     2280

cagccctaat gacatcacca acagtcaaag caattagaga ccatacctaa tattgtttaa     2340

attctagatg taggctaaca atgaaaagta tttgccaaac tgaataaaac tgtcatggtt     2400

accttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                2435


<210>  36
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Thr Trp Pro Val Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg 
1               5                   10                  15      


Gln Ile Asp Leu Leu Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe 
            20                  25                  30          


Thr Ser Lys Phe Pro Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg 
        35                  40                  45              


Trp Ser Val Ile Val Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu 
    50                  55                  60                  


Tyr Arg Cys Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val 
65                  70                  75                  80  


Met Arg Leu Thr Val Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu 
                85                  90                  95      


Phe Val Ala Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile 
            100                 105                 110         


Thr Thr Ile Ile Val Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg 
        115                 120                 125             


Arg Asp Leu Phe Thr Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn 
    130                 135                 140                 


Tyr Arg Ser Pro Ile Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp 
145                 150                 155                 160 


Asp Thr Arg Glu Asp Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg 
                165                 170                 175     


Pro Lys Thr Arg Val 
            180     


<210>  37
<211>  1409
<212>  DNA
<213>  Homo sapiens

<400>  37
aagtttccgc ggcgccttct ccccggccac tgcttgagcc gctgagaggg tggcgacgtc       60

ggggccatgg ggctgggccc ggtcttcctg cttctggctg gcatcttccc ttttgcacct      120

ccgggagctg ctgctgagcc ccacagtctt cgttataacc tcacggtgct gtcctgggat      180

ggatctgtgc agtcagggtt tctcactgag gtacatctgg atggtcagcc cttcctgcgc      240

tgtgacaggc agaaatgcag ggcaaagccc cagggacagt gggcagaaga tgtcctggga      300

aataagacat gggacagaga gaccagagac ttgacaggga acggaaagga cctcaggatg      360

accctggctc atatcaagga ccagaaagaa ggcttgcatt ccctccagga gattagggtc      420

tgtgagatcc atgaagacaa cagcaccagg agctcccagc atttctacta cgatggggag      480

ctcttcctct cccaaaacct ggagactaag gaatggacaa tgccccagtc ctccagagct      540

cagaccttgg ccatgaacgt caggaatttc ttgaaggaag atgccatgaa gaccaagaca      600

cactatcacg ctatgcatgc agactgcctg caggaactac ggcgatatct aaaatccggc      660

gtagtcctga ggagaacagt gccccccatg gtgaatgtca cccgcagcga ggcctcagag      720

ggcaacatta ccgtgacatg cagggcttct ggcttctatc cctggaatat cacactgagc      780

tggcgtcagg atggggtatc tttgagccac gacacccagc agtgggggga tgtcctgcct      840

gatgggaatg gaacctacca gacctgggtg gccaccagga tttgccaagg agaggagcag      900

aggttcacct gctacatgga acacagcggg aatcacagca ctcaccctgt gccctctggg      960

aaagtgctgg tgcttcagag tcattggcag acattccatg tttctgctgt tgctgctgct     1020

gctatttttg ttattattat tttctatgtc cgttgttgta agaagaaaac atcagctgca     1080

gagggtccag agctcgtgag cctgcaggtc ctggatcaac acccagttgg gacgagtgac     1140

cacagggatg ccacacagct cggatttcag cctctgatgt cagatcttgg gtccactggc     1200

tccactgagg gcgcctagac tctacagcca ggcagctggg attcaattcc ctgcctggac     1260

tcacgagcac tttccctctt ggtgcctcag tttcctgacc tatgaaacag agaaaataaa     1320

agcacttatt tattgttgtt ggaggctgca aaatgttagt agatatgagg cgtttgcagc     1380

tgtaccatat taaaaaaaaa aaaaaaaaa                                       1409


<210>  38
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  38
atggggctgg gcccggtctt cctgcttctg gctggcatct tcccttttgc acctccggga       60

gctgctgctg agccccacag tcttcgttat aacctcacgg tgctgtcctg ggatggatct      120

gtgcagtcag ggtttctcac tgaggtacat ctggatggtc agcccttcct gcgctgtgac      180

aggcagaaat gcagggcaaa gccccaggga cagtgggcag aagatgtcct gggaaataag      240

acatgggaca gagagaccag agacttgaca gggaacggaa aggacctcag gatgaccctg      300

gctcatatca aggaccagaa agaaggcttg cattccctcc aggagattag ggtctgtgag      360

atccatgaag acaacagcac caggagctcc cagcatttct actacgatgg ggagctcttc      420

ctctcccaaa acctggagac taaggaatgg acaatgcccc agtcctccag agctcagacc      480

ttggccatga acgtcaggaa tttcttgaag gaagatgcca tgaagaccaa gacacactat      540

cacgctatgc atgcagactg cctgcaggaa ctacggcgat atctaaaatc cggcgtagtc      600

ctgaggagaa cagtgccccc catggtgaat gtcacccgca gcgaggcctc agagggcaac      660

attaccgtga catgcagggc ttctggcttc tatccctgga atatcacact gagctggcgt      720

caggatgggg tatctttgag ccacgacacc cagcagtggg gggatgtcct gcctgatggg      780

aatggaacct accagacctg ggtggccacc aggatttgcc aaggagagga gcagaggttc      840

acctgctaca tggaacacag cgggaatcac agcactcacc ctgtgccctc tgggaaagtg      900

ctggtgcttc agagtcattg gcagacattc catgtttctg ctgttgctgc tgctgctatt      960

tttgttatta ttattttcta tgtccgttgt tgtaagaaga aaacatcagc tgcagagggt     1020

ccagagctcg tgagcctgca ggtcctggat caacacccag ttgggacgag tgaccacagg     1080

gatgccacac agctcggatt tcagcctctg atgtcagatc ttgggtccac tggctccact     1140

gagggcgcct ag                                                         1152


<210>  39
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  40
<211>  2278
<212>  DNA
<213>  Homo sapiens

<400>  40
gtatcatttc agtgaaggtc actccagtct ttcatggagg ccaaactaag ggtgtaaatt       60

aggatcctca ctgaagtggc gggaccctaa gaggcttttt cctggcccct tagttgtggg      120

ttttcctgcg ggcggcgcag ccggtttcca tcagaaccgc ccagaggcgg acgctgcctt      180

cctggggtga cggagcagca ggaagcgttt tcggatcctg gaatacgtgg gcggcccgtg      240

ggaggggctg aggcgcagtt tcctactcac ccggatccga atcctccgcg gtgctgtttc      300

aagagagccg gattccagat cacgctccag cccggactcg gaattcctgc cctgcgggtc      360

tgcattttca taacgggcag gtgtgagtgc cctgcagctg gagaccagaa gcctgaaggc      420

agctcggccc tccccagccc acagcgccgt tattccgttt ctatatcagt aaacacattt      480

cattttccgt agaccagggc ggggtgacgg gtgatcccag tcctcgcagt gaattccggg      540

cagcaaaatt caaaacacat gcggccaagg ccgggcacgg tggttcacgc ctgtaatccc      600

agcactttgg gaggtcgagg cgggcgatca cctgaggtcg ggagctcgag accaacctga      660

ccaacatggg gaaatcccgt ctctactaaa aatataaaat tagacgggct tggtggtgaa      720

tgcctgtaat cccagctagt cgggaggctg aggcaggaga atcgcttaaa ccttggaggc      780

ggaggttgcg gtgagccgag atcgcgccat tgcacttcag cctgggcaac aagagggaaa      840

actccgtcgc aaaaactttc gggggcggag cggagccccg ccctgggtta tgtaagcgac      900

cgcgctgggc cgtttctctt tcttttccgg accctgcagt ggcgcctaaa gtctgagaga      960

gggaagtcgc ctctgtgctc gtgagtgcat ggggtataag agccccacag tcttcgttat     1020

aacctcacgg tgctgtcctg ggatggatct gtgcagtcag ggtttcttgc tgaggtacat     1080

ctggatggtc agcccttcct gcgctatgac aggcagaaat gcagggcaaa gccccaggga     1140

cagtgggcag aagatgtcct gggaaataag acatgggaca gagagaccag ggacttgaca     1200

gggaacggaa aggacctcag gatgaccctg gctcatatca aggaccagaa agaaggcttg     1260

cattccctcc aggagattag ggtctgtgag atccatgaag acaacagcac caggagctcc     1320

cagcatttct actacgatgg ggagctcttc ctctcccaaa acctggagac tgaggaatgg     1380

acagtgcccc agtcctccag agctcagacc ttggccatga acgtcaggaa tttcttgaag     1440

gaagatgcca tgaagaccaa gacacactat cacgctatgc atgcagactg cctgcaggaa     1500

ctacggcgat atctagaatc cggcgtagtc ctgaggagaa cagtgccccc catggtgaat     1560

gtcacccgca gcgaggcctc agagggcaac atcaccgtga catgcagggc ttccagcttc     1620

tatccccgga atatcatact gacctggcgt caggatgggg tatctttgag ccacgacacc     1680

cagcagtggg gggatgtcct gcctgatggg aatggaacct accagacctg ggtggccacc     1740

aggatttgcc gaggagagga gcagaggttc acctgctaca tggaacacag cgggaatcac     1800

agcactcacc ctgtgccctc tgggaaagtg ctggtgcttc agagtcattg gcagacattc     1860

catgtttctg ctgttgctgc tggctgctgc tatttttgtt attattattt tctatgtccg     1920

ttgttgtaag aagaaaacat cagctgcaga gggtccagag ctcgtgagcc tgcaggtcct     1980

ggatcaacac ccagttggga cgagtgacca cagggatgcc acacagctcg gatttcagcc     2040

tctgatgtca gctcttgggt ccactggctc cactgagggc acctagactc tacagccagg     2100

cggctggaat tgaattccct gcctggatct cacaagcact ttccctcttg gtgcctcagt     2160

ttcctgacct atgaaacaga gaaaataaaa gcacttattt attgttgttg gaggctgcaa     2220

aatgttagta gatatgaggc atttgcagct gtgccatatt aaaaaaaaaa aaaaaaaa       2278


<210>  41
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  41
atgaccctgg ctcatatcaa ggaccagaaa gaaggcttgc attccctcca ggagattagg       60

gtctgtgaga tccatgaaga caacagcacc aggagctccc agcatttcta ctacgatggg      120

gagctcttcc tctcccaaaa cctggagact gaggaatgga cagtgcccca gtcctccaga      180

gctcagacct tggccatgaa cgtcaggaat ttcttgaagg aagatgccat gaagaccaag      240

acacactatc acgctatgca tgcagactgc ctgcaggaac tacggcgata tctagaatcc      300

ggcgtagtcc tgaggagaac agtgcccccc atggtgaatg tcacccgcag cgaggcctca      360

gagggcaaca tcaccgtgac atgcagggct tccagcttct atccccggaa tatcatactg      420

acctggcgtc aggatggggt atctttgagc cacgacaccc agcagtgggg ggatgtcctg      480

cctgatggga atggaaccta ccagacctgg gtggccacca ggatttgccg aggagaggag      540

cagaggttca cctgctacat ggaacacagc gggaatcaca gcactcaccc tgtgccctct      600

gggaaagtgc tggtgcttca gagtcattgg cagacattcc atgtttctgc tgttgctgct      660

ggctgctgct atttttgtta ttattatttt ctatgtccgt tgttgtaa                   708


<210>  42
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu 
1               5                   10                  15      


Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser 
            20                  25                  30          


Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu 
        35                  40                  45              


Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu 
    50                  55                  60                  


Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys 
65                  70                  75                  80  


Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg 
                85                  90                  95      


Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met Val 
            100                 105                 110         


Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys 
        115                 120                 125             


Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg Gln 
    130                 135                 140                 


Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu 
145                 150                 155                 160 


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys 
                165                 170                 175     


Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
            180                 185                 190         


His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser 
        195                 200                 205             


His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Gly Cys Cys Tyr 
    210                 215                 220                 


Phe Cys Tyr Tyr Tyr Phe Leu Cys Pro Leu Leu 
225                 230                 235 


<210>  43
<211>  2258
<212>  DNA
<213>  Homo sapiens

<400>  43
gtatcatttc agtgaaggtc actccagtct ttcatggagg ccaaactaag ggtgtaaatt       60

aggatcctca ctgaagtggc gggaccctaa gaggcttttt cctggcccct tagttgtggg      120

ttttcctgcg ggcggcgcag ccggtttcca tcagaaccgc ccagaggcgg acgctgcctt      180

cctggggtga cggagcagca ggaagcgttt tcggatcctg gaatacgtgg gcggcccgtg      240

ggaggggctg aggcgcagtt tcctactcac ccggatccga atcctccgcg gtgctgtttc      300

aagagagccg gattccagat cacgctccag cccggactcg gaattcctgc cctgcgggtc      360

tgcattttca taacgggcag gtgtgagtgc cctgcagctg gagaccagaa gcctgaaggc      420

agctcggccc tccccagccc acagcgccgt tattccgttt ctatatcagt aaacacattt      480

cattttccgt agaccagggc ggggtgacgg gtgatcccag tcctcgcagt gaattccggg      540

cagcaaaatt caaaacacat gcggccaagg ccgggcacgg tggttcacgc ctgtaatccc      600

agcactttgg gaggtcgagg cgggcgatca cctgaggtcg ggagctcgag accaacctga      660

ccaacatggg gaaatcccgt ctctactaaa aatataaaat tagacgggct tggtggtgaa      720

tgcctgtaat cccagctagt cgggaggctg aggcaggaga atcgcttaaa ccttggaggc      780

ggaggttgcg gtgagccgag atcgcgccat tgcacttcag cctgggcaac aagagggaaa      840

actccgtcgc aaaaactttc gggggcggag cggagccccg ccctgggtta tgtaagcgac      900

cgcgctgggc cgtttctctt tcttttccgg accctgcagt ggcgcctaaa gtctgagaga      960

gggaagtcgc ctctgtgctc agccccacag tcttcgttat aacctcacgg tgctgtcctg     1020

ggatggatct gtgcagtcag ggtttcttgc tgaggtacat ctggatggtc agcccttcct     1080

gcgctatgac aggcagaaat gcagggcaaa gccccaggga cagtgggcag aagatgtcct     1140

gggaaataag acatgggaca gagagaccag ggacttgaca gggaacggaa aggacctcag     1200

gatgaccctg gctcatatca aggaccagaa agaaggcttg cattccctcc aggagattag     1260

ggtctgtgag atccatgaag acaacagcac caggagctcc cagcatttct actacgatgg     1320

ggagctcttc ctctcccaaa acctggagac tgaggaatgg acagtgcccc agtcctccag     1380

agctcagacc ttggccatga acgtcaggaa tttcttgaag gaagatgcca tgaagaccaa     1440

gacacactat cacgctatgc atgcagactg cctgcaggaa ctacggcgat atctagaatc     1500

cggcgtagtc ctgaggagaa cagtgccccc catggtgaat gtcacccgca gcgaggcctc     1560

agagggcaac atcaccgtga catgcagggc ttccagcttc tatccccgga atatcatact     1620

gacctggcgt caggatgggg tatctttgag ccacgacacc cagcagtggg gggatgtcct     1680

gcctgatggg aatggaacct accagacctg ggtggccacc aggatttgcc gaggagagga     1740

gcagaggttc acctgctaca tggaacacag cgggaatcac agcactcacc ctgtgccctc     1800

tgggaaagtg ctggtgcttc agagtcattg gcagacattc catgtttctg ctgttgctgc     1860

tggctgctgc tatttttgtt attattattt tctatgtccg ttgttgtaag aagaaaacat     1920

cagctgcaga gggtccagag ctcgtgagcc tgcaggtcct ggatcaacac ccagttggga     1980

cgagtgacca cagggatgcc acacagctcg gatttcagcc tctgatgtca gctcttgggt     2040

ccactggctc cactgagggc acctagactc tacagccagg cggctggaat tgaattccct     2100

gcctggatct cacaagcact ttccctcttg gtgcctcagt ttcctgacct atgaaacaga     2160

gaaaataaaa gcacttattt attgttgttg gaggctgcaa aatgttagta gatatgaggc     2220

atttgcagct gtgccatatt aaaaaaaaaa aaaaaaaa                             2258


<210>  44
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  44
atgaccctgg ctcatatcaa ggaccagaaa gaaggcttgc attccctcca ggagattagg       60

gtctgtgaga tccatgaaga caacagcacc aggagctccc agcatttcta ctacgatggg      120

gagctcttcc tctcccaaaa cctggagact gaggaatgga cagtgcccca gtcctccaga      180

gctcagacct tggccatgaa cgtcaggaat ttcttgaagg aagatgccat gaagaccaag      240

acacactatc acgctatgca tgcagactgc ctgcaggaac tacggcgata tctagaatcc      300

ggcgtagtcc tgaggagaac agtgcccccc atggtgaatg tcacccgcag cgaggcctca      360

gagggcaaca tcaccgtgac atgcagggct tccagcttct atccccggaa tatcatactg      420

acctggcgtc aggatggggt atctttgagc cacgacaccc agcagtgggg ggatgtcctg      480

cctgatggga atggaaccta ccagacctgg gtggccacca ggatttgccg aggagaggag      540

cagaggttca cctgctacat ggaacacagc gggaatcaca gcactcaccc tgtgccctct      600

gggaaagtgc tggtgcttca gagtcattgg cagacattcc atgtttctgc tgttgctgct      660

ggctgctgct atttttgtta ttattatttt ctatgtccgt tgttgtaa                   708


<210>  45
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu 
1               5                   10                  15      


Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser 
            20                  25                  30          


Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu 
        35                  40                  45              


Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu 
    50                  55                  60                  


Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys 
65                  70                  75                  80  


Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg 
                85                  90                  95      


Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met Val 
            100                 105                 110         


Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys 
        115                 120                 125             


Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg Gln 
    130                 135                 140                 


Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu 
145                 150                 155                 160 


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys 
                165                 170                 175     


Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
            180                 185                 190         


His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser 
        195                 200                 205             


His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Gly Cys Cys Tyr 
    210                 215                 220                 


Phe Cys Tyr Tyr Tyr Phe Leu Cys Pro Leu Leu 
225                 230                 235 


<210>  46
<211>  2084
<212>  DNA
<213>  Homo sapiens

<400>  46
gtatcatttc agtgaaggtc actccagtct ttcatggagg ccaaactaag ggtgtaaatt       60

aggatcctca ctgaagtggc gggaccctaa gaggcttttt cctggcccct tagttgtggg      120

ttttcctgcg ggcggcgcag ccggtttcca tcagaaccgc ccagaggcgg acgctgcctt      180

cctggggtga cggagcagca ggaagcgttt tcggatcctg gaatacgtgg gcggcccgtg      240

ggaggggctg aggcgcagtt tcctactcac ccggatccga atcctccgcg gtgctgtttc      300

aagagagccg gattccagat cacgctccag cccggactcg gaattcctgc cctgcgggtc      360

tgcattttca taacgggcag gtgtgagtgc cctgcagctg gagaccgaag cctgaaggca      420

gctcggccct ccccagccca cagcgccgtt attccgtttc tatatcagta aacacatttc      480

attttccgta gaccagggcg gggtgacggg tgatcccagt cctcgcagtg aattccgggc      540

agcaaaattc aaaacacatg cggccaaggc cgggcacggt ggttcacgcc tgtaatccca      600

gcactttggg aggtcgaggc gggcgatcac ctgaggtcgg gagctcgaga ccaacctgac      660

caacatgggg aaatcccgtc tctactaaaa atataaaatt agacgggctt ggtggtgaat      720

gcctgtaatc ccagctagtc gggaggctga ggcaggagaa tcgcttaaac cttggaggcg      780

gaggttgcgg tgagccgaga tcgcgccatt gcacttcagc ctgggcaaca agagggaaaa      840

ctccgtcgca aaaactttcg ggggcggagc ggagccccgc cctgggttat gtaagcgacc      900

gcgctgggcc gtttctcttt cttttccgga ccctgcagtg gcgcctaaag tctgagagag      960

ggaagtcgcc tctgtgctca gccccacagt cttcgttata acctcacggt gctgtcctgg     1020

gatggatctg tgcagtcagg gtttcttgcg aggtacatct ggatggtcag cccttcctgc     1080

gctatgacag gcagaaatgc agggcaaagc cccagggaca gtgggcagaa gatgtcctgg     1140

gaaataagac atgggacaga gagaccaggg acttgacagg gaacggaaag gacctcagga     1200

tgaccctggc tcatatcaag gaccagaaag aaggaatttc ttgaaggaag atgccatgaa     1260

gaccaagaca cactatcacg ctatgcatgc agactgcctg caggaactac ggcgatatct     1320

agaatccggc gtagtcctga ggagaacagt gccccccatg gtgaatgtca cccgcagcga     1380

ggcctcagag ggcaacatca ccgtgacatg cagggcttcc agcttctatc cccggaatat     1440

catactgacc tggcgtcagg atggggtatc tttgagccac gacacccagc agtgggggga     1500

tgtcctgcct gatgggaatg gaacctacca gacctgggtg gccaccagga tttgccgagg     1560

agaggagcag aggttcacct gctacatgga acacagcggg aatcacagca ctcaccctgt     1620

gccctctggg aaagtgctgg tgcttcagag tcattggcag acattccatg tttctgctgt     1680

tgctgctggc tgctgctatt tttgttatta ttattttcta tgtccgttgt tgtaagaaga     1740

aaacatcagc tgcagagggt ccagagctcg tgagcctgca ggtcctggat caacacccag     1800

ttgggacgag tgaccacagg gatgccacac agctcggatt tcagcctctg atgtcagctc     1860

ttgggtccac tggctccact gagggcacct agactctaca gccaggcggc tggaattgaa     1920

ttccctgcct ggatctcaca agcactttcc ctcttggtgc ctcagtttcc tgacctatga     1980

aacagagaaa ataaaagcac ttatttattg ttgttggagg ctgcaaaatg ttagtagata     2040

tgaggcattt gcagctgtgc catattaaaa aaaaaaaaaa aaaa                      2084


<210>  47
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  47
atgggacaga gagaccaggg acttgacagg gaacggaaag gacctcagga tgaccctggc       60

tcatatcaag gaccagaaag aaggaatttc ttgaaggaag atgccatgaa gaccaagaca      120

cactatcacg ctatgcatgc agactgcctg caggaactac ggcgatatct agaatccggc      180

gtagtcctga ggagaacagt gccccccatg gtgaatgtca cccgcagcga ggcctcagag      240

ggcaacatca ccgtgacatg cagggcttcc agcttctatc cccggaatat catactgacc      300

tggcgtcagg atggggtatc tttgagccac gacacccagc agtgggggga tgtcctgcct      360

gatgggaatg gaacctacca gacctgggtg gccaccagga tttgccgagg agaggagcag      420

aggttcacct gctacatgga acacagcggg aatcacagca ctcaccctgt gccctctggg      480

aaagtgctgg tgcttcagag tcattggcag acattccatg tttctgctgt tgctgctggc      540

tgctgctatt tttgttatta ttattttcta tgtccgttgt tgtaa                      585


<210>  48
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Gln Arg Asp Gln Gly Leu Asp Arg Glu Arg Lys Gly Pro Gln 
1               5                   10                  15      


Asp Asp Pro Gly Ser Tyr Gln Gly Pro Glu Arg Arg Asn Phe Leu Lys 
            20                  25                  30          


Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met His Ala Asp 
        35                  40                  45              


Cys Leu Gln Glu Leu Arg Arg Tyr Leu Glu Ser Gly Val Val Leu Arg 
    50                  55                  60                  


Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser Glu 
65                  70                  75                  80  


Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn 
                85                  90                  95      


Ile Ile Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp Thr 
            100                 105                 110         


Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr 
        115                 120                 125             


Trp Val Ala Thr Arg Ile Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys 
    130                 135                 140                 


Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val Pro Ser Gly 
145                 150                 155                 160 


Lys Val Leu Val Leu Gln Ser His Trp Gln Thr Phe His Val Ser Ala 
                165                 170                 175     


Val Ala Ala Gly Cys Cys Tyr Phe Cys Tyr Tyr Tyr Phe Leu Cys Pro 
            180                 185                 190         


Leu Leu 
        


<210>  49
<211>  1414
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala Ala Gly Thr Thr Thr Cys Cys Gly Cys Gly Gly Cys Gly Cys Cys 
1               5                   10                  15      


Thr Thr Cys Thr Cys Cys Cys Cys Gly Gly Cys Cys Ala Cys Thr Gly 
            20                  25                  30          


Cys Thr Thr Gly Ala Gly Cys Cys Gly Cys Thr Gly Ala Gly Ala Gly 
        35                  40                  45              


Gly Gly Thr Gly Gly Cys Gly Ala Cys Gly Thr Cys Gly Gly Gly Gly 
    50                  55                  60                  


Cys Cys Ala Thr Gly Gly Gly Gly Cys Thr Gly Gly Gly Cys Cys Cys 
65                  70                  75                  80  


Gly Gly Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Thr Cys Thr Gly 
                85                  90                  95      


Gly Cys Thr Gly Gly Cys Ala Thr Cys Thr Thr Cys Cys Cys Thr Thr 
            100                 105                 110         


Thr Thr Gly Cys Ala Cys Cys Thr Cys Cys Gly Gly Gly Ala Gly Cys 
        115                 120                 125             


Thr Gly Cys Thr Gly Cys Thr Gly Ala Gly Cys Cys Cys Cys Ala Cys 
    130                 135                 140                 


Ala Gly Thr Cys Thr Thr Cys Gly Thr Thr Ala Thr Ala Ala Cys Cys 
145                 150                 155                 160 


Thr Cys Ala Cys Gly Gly Thr Gly Cys Thr Gly Thr Cys Cys Thr Gly 
                165                 170                 175     


Gly Gly Ala Thr Gly Gly Ala Thr Cys Thr Gly Thr Gly Cys Ala Gly 
            180                 185                 190         


Thr Cys Ala Gly Gly Gly Thr Thr Thr Cys Thr Thr Gly Cys Thr Gly 
        195                 200                 205             


Ala Gly Gly Thr Ala Cys Ala Thr Cys Thr Gly Gly Ala Thr Gly Gly 
    210                 215                 220                 


Thr Cys Ala Gly Cys Cys Cys Thr Thr Cys Cys Thr Gly Cys Gly Cys 
225                 230                 235                 240 


Thr Ala Thr Gly Ala Cys Ala Gly Gly Cys Ala Gly Ala Ala Ala Thr 
                245                 250                 255     


Gly Cys Ala Gly Gly Gly Cys Ala Ala Ala Gly Cys Cys Cys Cys Ala 
            260                 265                 270         


Gly Gly Gly Ala Cys Ala Gly Thr Gly Gly Gly Cys Ala Gly Ala Ala 
        275                 280                 285             


Gly Ala Thr Gly Thr Cys Cys Thr Gly Gly Gly Ala Ala Ala Thr Ala 
    290                 295                 300                 


Ala Gly Ala Cys Ala Thr Gly Gly Gly Ala Cys Ala Gly Ala Gly Ala 
305                 310                 315                 320 


Gly Ala Cys Cys Ala Gly Gly Gly Ala Cys Thr Thr Gly Ala Cys Ala 
                325                 330                 335     


Gly Gly Gly Ala Ala Cys Gly Gly Ala Ala Ala Gly Gly Ala Cys Cys 
            340                 345                 350         


Thr Cys Ala Gly Gly Ala Thr Gly Ala Cys Cys Cys Thr Gly Gly Cys 
        355                 360                 365             


Thr Cys Ala Thr Ala Thr Cys Ala Ala Gly Gly Ala Cys Cys Ala Gly 
    370                 375                 380                 


Ala Ala Ala Gly Ala Ala Gly Gly Cys Thr Thr Gly Cys Ala Thr Thr 
385                 390                 395                 400 


Cys Cys Cys Thr Cys Cys Ala Gly Gly Ala Gly Ala Thr Thr Ala Gly 
                405                 410                 415     


Gly Gly Thr Cys Thr Gly Thr Gly Ala Gly Ala Thr Cys Cys Ala Thr 
            420                 425                 430         


Gly Ala Ala Gly Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys Cys Ala 
        435                 440                 445             


Gly Gly Ala Gly Cys Thr Cys Cys Cys Ala Gly Cys Ala Thr Thr Thr 
    450                 455                 460                 


Cys Thr Ala Cys Thr Ala Cys Gly Ala Thr Gly Gly Gly Gly Ala Gly 
465                 470                 475                 480 


Cys Thr Cys Thr Thr Cys Cys Thr Cys Thr Cys Cys Cys Ala Ala Ala 
                485                 490                 495     


Ala Cys Cys Thr Gly Gly Ala Gly Ala Cys Thr Gly Ala Gly Gly Ala 
            500                 505                 510         


Ala Thr Gly Gly Ala Cys Ala Gly Thr Gly Cys Cys Cys Cys Ala Gly 
        515                 520                 525             


Thr Cys Cys Thr Cys Cys Ala Gly Ala Gly Cys Thr Cys Ala Gly Ala 
    530                 535                 540                 


Cys Cys Thr Thr Gly Gly Cys Cys Ala Thr Gly Ala Ala Cys Gly Thr 
545                 550                 555                 560 


Cys Ala Gly Gly Ala Ala Thr Thr Thr Cys Thr Thr Gly Ala Ala Gly 
                565                 570                 575     


Gly Ala Ala Gly Ala Thr Gly Cys Cys Ala Thr Gly Ala Ala Gly Ala 
            580                 585                 590         


Cys Cys Ala Ala Gly Ala Cys Ala Cys Ala Cys Thr Ala Thr Cys Ala 
        595                 600                 605             


Cys Gly Cys Thr Ala Thr Gly Cys Ala Thr Gly Cys Ala Gly Ala Cys 
    610                 615                 620                 


Thr Gly Cys Cys Thr Gly Cys Ala Gly Gly Ala Ala Cys Thr Ala Cys 
625                 630                 635                 640 


Gly Gly Cys Gly Ala Thr Ala Thr Cys Thr Ala Gly Ala Ala Thr Cys 
                645                 650                 655     


Cys Gly Gly Cys Gly Thr Ala Gly Thr Cys Cys Thr Gly Ala Gly Gly 
            660                 665                 670         


Ala Gly Ala Ala Cys Ala Gly Thr Gly Cys Cys Cys Cys Cys Cys Ala 
        675                 680                 685             


Thr Gly Gly Thr Gly Ala Ala Thr Gly Thr Cys Ala Cys Cys Cys Gly 
    690                 695                 700                 


Cys Ala Gly Cys Gly Ala Gly Gly Cys Cys Thr Cys Ala Gly Ala Gly 
705                 710                 715                 720 


Gly Gly Cys Ala Ala Cys Ala Thr Cys Ala Cys Cys Gly Thr Gly Ala 
                725                 730                 735     


Cys Ala Thr Gly Cys Ala Gly Gly Gly Cys Thr Thr Cys Cys Ala Gly 
            740                 745                 750         


Cys Thr Thr Cys Thr Ala Thr Cys Cys Cys Cys Gly Gly Ala Ala Thr 
        755                 760                 765             


Ala Thr Cys Ala Thr Ala Cys Thr Gly Ala Cys Cys Thr Gly Gly Cys 
    770                 775                 780                 


Gly Thr Cys Ala Gly Gly Ala Thr Gly Gly Gly Gly Thr Ala Thr Cys 
785                 790                 795                 800 


Thr Thr Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Cys Ala Cys Cys 
                805                 810                 815     


Cys Ala Gly Cys Ala Gly Thr Gly Gly Gly Gly Gly Gly Ala Thr Gly 
            820                 825                 830         


Thr Cys Cys Thr Gly Cys Cys Thr Gly Ala Thr Gly Gly Gly Ala Ala 
        835                 840                 845             


Thr Gly Gly Ala Ala Cys Cys Thr Ala Cys Cys Ala Gly Ala Cys Cys 
    850                 855                 860                 


Thr Gly Gly Gly Thr Gly Gly Cys Cys Ala Cys Cys Ala Gly Gly Ala 
865                 870                 875                 880 


Thr Thr Thr Gly Cys Cys Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Ala Gly Ala Gly Gly Thr Thr Cys Ala Cys Cys Thr Gly Cys 
            900                 905                 910         


Thr Ala Cys Ala Thr Gly Gly Ala Ala Cys Ala Cys Ala Gly Cys Gly 
        915                 920                 925             


Gly Gly Ala Ala Thr Cys Ala Cys Ala Gly Cys Ala Cys Thr Cys Ala 
    930                 935                 940                 


Cys Cys Cys Thr Gly Thr Gly Cys Cys Cys Thr Cys Thr Gly Gly Gly 
945                 950                 955                 960 


Ala Ala Ala Gly Thr Gly Cys Thr Gly Gly Thr Gly Cys Thr Thr Cys 
                965                 970                 975     


Ala Gly Ala Gly Thr Cys Ala Thr Thr Gly Gly Cys Ala Gly Ala Cys 
            980                 985                 990         


Ala Thr Thr Cys Cys Ala Thr Gly  Thr Thr Thr Cys Thr  Gly Cys Thr 
        995                 1000                 1005             


Gly Thr  Thr Gly Cys Thr Gly  Cys Thr Gly Gly Cys  Thr Gly Cys 
    1010                 1015                 1020             


Thr Gly  Cys Thr Ala Thr Thr  Thr Thr Thr Gly Thr  Thr Ala Thr 
    1025                 1030                 1035             


Thr Ala  Thr Thr Ala Thr Thr  Thr Thr Cys Thr Ala  Thr Gly Thr 
    1040                 1045                 1050             


Cys Cys  Gly Thr Thr Gly Thr  Thr Gly Thr Ala Ala  Gly Ala Ala 
    1055                 1060                 1065             


Gly Ala  Ala Ala Ala Cys Ala  Thr Cys Ala Gly Cys  Thr Gly Cys 
    1070                 1075                 1080             


Ala Gly  Ala Gly Gly Gly Thr  Cys Cys Ala Gly Ala  Gly Cys Thr 
    1085                 1090                 1095             


Cys Gly  Thr Gly Ala Gly Cys  Cys Thr Gly Cys Ala  Gly Gly Thr 
    1100                 1105                 1110             


Cys Cys  Thr Gly Gly Ala Thr  Cys Ala Ala Cys Ala  Cys Cys Cys 
    1115                 1120                 1125             


Ala Gly  Thr Thr Gly Gly Gly  Ala Cys Gly Ala Gly  Thr Gly Ala 
    1130                 1135                 1140             


Cys Cys  Ala Cys Ala Gly Gly  Gly Ala Thr Gly Cys  Cys Ala Cys 
    1145                 1150                 1155             


Ala Cys  Ala Gly Cys Thr Cys  Gly Gly Ala Thr Thr  Thr Cys Ala 
    1160                 1165                 1170             


Gly Cys  Cys Thr Cys Thr Gly  Ala Thr Gly Thr Cys  Ala Gly Cys 
    1175                 1180                 1185             


Thr Cys  Thr Thr Gly Gly Gly  Thr Cys Cys Ala Cys  Thr Gly Gly 
    1190                 1195                 1200             


Cys Thr  Cys Cys Ala Cys Thr  Gly Ala Gly Gly Gly  Cys Ala Cys 
    1205                 1210                 1215             


Cys Thr  Ala Gly Ala Cys Thr  Cys Thr Ala Cys Ala  Gly Cys Cys 
    1220                 1225                 1230             


Ala Gly  Gly Cys Gly Gly Cys  Thr Gly Gly Ala Ala  Thr Thr Gly 
    1235                 1240                 1245             


Ala Ala  Thr Thr Cys Cys Cys  Thr Gly Cys Cys Thr  Gly Gly Ala 
    1250                 1255                 1260             


Thr Cys  Thr Cys Ala Cys Ala  Ala Gly Cys Ala Cys  Thr Thr Thr 
    1265                 1270                 1275             


Cys Cys  Cys Thr Cys Thr Thr  Gly Gly Thr Gly Cys  Cys Thr Cys 
    1280                 1285                 1290             


Ala Gly  Thr Thr Thr Cys Cys  Thr Gly Ala Cys Cys  Thr Ala Thr 
    1295                 1300                 1305             


Gly Ala  Ala Ala Cys Ala Gly  Ala Gly Ala Ala Ala  Ala Thr Ala 
    1310                 1315                 1320             


Ala Ala  Ala Gly Cys Ala Cys  Thr Thr Ala Thr Thr  Thr Ala Thr 
    1325                 1330                 1335             


Thr Gly  Thr Thr Gly Thr Thr  Gly Gly Ala Gly Gly  Cys Thr Gly 
    1340                 1345                 1350             


Cys Ala  Ala Ala Ala Thr Gly  Thr Thr Ala Gly Thr  Ala Gly Ala 
    1355                 1360                 1365             


Thr Ala  Thr Gly Ala Gly Gly  Cys Ala Thr Thr Thr  Gly Cys Ala 
    1370                 1375                 1380             


Gly Cys  Thr Gly Thr Gly Cys  Cys Ala Thr Ala Thr  Thr Ala Ala 
    1385                 1390                 1395             


Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1400                 1405                 1410             


Ala 
    


<210>  50
<211>  999
<212>  DNA
<213>  Homo sapiens

<400>  50
atggggctgg gcccggtctt tctgcttctg gctggcatct tcccttttgc acctccggga       60

gctgctgctg agccccacag tcttcgttat aacctcacgg tgctgtcctg ggatggatct      120

gtgcagtcag ggtttcttgc tgaggtacat ctggatggtc agcccttcct gcgctatgac      180

aggcagaaat gcagggcaaa gccccaggga cagtgggcag aagatgtcct gggaaataag      240

acatgggaca gagagaccag ggacttgaca gggaacggaa aggacctcag gatgaccctg      300

gctcatatca aggaccagaa agaaggcttg cattccctcc aggagattag ggtctgtgag      360

atccatgaag acaacagcac caggagctcc cagcatttct actacgatgg ggagctcttc      420

ctctcccaaa acctggagac tgaggaatgg acagtgcccc agtcctccag agctcagacc      480

ttggccatga acgtcaggaa tttcttgaag gaagatgcca tgaagaccaa gacacactat      540

cacgctatgc atgcagactg cctgcaggaa ctacggcgat atctagaatc cggcgtagtc      600

ctgaggagaa cagtgccccc catggtgaat gtcacccgca gcgaggcctc agagggcaac      660

atcaccgtga catgcagggc ttccagcttc tatccccgga atatcatact gacctggcgt      720

caggatgggg tatctttgag ccacgacacc cagcagtggg gggatgtcct gcctgatggg      780

aatggaacct accagacctg ggtggccacc aggatttgcc gaggagagga gcagaggttc      840

acctgctaca tggaacacag cgggaatcac agcactcacc ctgtgccctc tgggaaagtg      900

ctggtgcttc agagtcattg gcagacattc catgtttctg ctgttgctgc tggctgctgc      960

tatttttgtt attattattt tctatgtccg ttgttgtaa                             999


<210>  51
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Gly Cys Cys 
305                 310                 315                 320 


Tyr Phe Cys Tyr Tyr Tyr Phe Leu Cys Pro Leu Leu 
                325                 330         


<210>  52
<211>  2426
<212>  DNA
<213>  Homo sapiens

<400>  52
gaattttgtg agcgaccgcg ctgggccgtt tctctttctt ttccggaccc tgcagtggcg       60

cctaaagtct gcgaggagga agtcgcctct gtgctcgtga gtccagggat ctaagagccc      120

cacagtcttc gttacaacct catggtgctg tcccaggatg gatctgtgca gtcagggttt      180

ctcgctgagg gacatctgga tggtcagccc ttcctgcgct atgacaggca gaaacgcagg      240

gcaaagcccc agggacagtg ggcagaaaat gtcctgggag ctaagacctg ggacacagag      300

accgaggact tgacagagaa tgggcaagac ctcaggagga ccctgactca tatcaaggac      360

cagaaaggag gcttgcattc cctccaggag attagggtct gtgagatcca tgaagacagc      420

agcaccaggg gctcccggca tttctactac gatggggagc tcttcctctc ccaaaacctg      480

gagactcaag aatcgacagt gccccagtcc tccagagctc agaccttggc tatgaacgtc      540

acaaatttct ggaaggaaga tgccatgaag accaagacac actatcgcgc tatgcaggca      600

gactgcctgc agaaactaca gcgatatctg aaatccgggg tggccatcag gagaacagtg      660

ccccccatgg tgaatgtcac ctgcagcgag gtctcagagg gcaacatcac cgtgacatgc      720

agggcttcca gcttctatcc ccggaatatc acactgacct ggcgtcagga tggggtatct      780

ttgagccaca acacccagca gtggggggat gtcctgcctg atgggaatgg aacctaccag      840

acctgggtgg ccaccaggat tcgccaagga gaggagcaga ggttcacctg ctacatggaa      900

cacagcggga atcacggcac tcaccctgtg ccctctggga aggcgctggt gcttcagagt      960

caacggacag actttccata tgtttctgct gctatgccat gttttgttat tattattatt     1020

ctctgtgtcc cttgttgcaa gaagaaaaca tcagcggcag agggtccaga gcttgtgagc     1080

ctgcaggtcc tggatcaaca cccagttggg acaggagacc acagggatgc agcacagctg     1140

ggatttcagc ctctgatgtc agctactggg tccactggtt ccactgaggg cacctagact     1200

ctacagccag gcggccagga ttcaactccc tgcctggatc tcaccagcac tttccctctg     1260

tttcctgacc tatgaaacag agaaaataac atcacttatt tattgttgtt ggatgctgca     1320

aagtgttagt aggtatgagg tgtttgctgc tctgccacgt agagagccag caaagggatc     1380

atgaccaact caacattcca ttggaggcta tatgatcaaa cagcaaattg tttatcatga     1440

atgcaggatg tgggcaaact cacgactgct cctgccaaca gaaggtttgc tgagggcatt     1500

cactccatgg tgctcattgg agttatctac tgggtcatct agagcctatt gtttgaggaa     1560

tgcagtctta caagcctact ctggacccag cagctgactc cttcttccac ccctcttctt     1620

gctatctcct ataccaataa atacgaaggg ctgtggaaga tcagagccct tgttcacgag     1680

aagcaagaag ccccctgacc ccttgttcca aatatactct tttgtctttc tctttattcc     1740

cacgttcgcc ctttgttcag tccaatacag ggttgtgggg cccttaacag tgccatatta     1800

attggtatca ttatttctgt tgtttttgtt tttgtttttg tttttgtttt tgagacagag     1860

tctcactctg tcacccaggc tgcagttcac tggtgtgatc tcagctcact gcaacctctg     1920

cctcccaggt tcaagcactt ctcgtacctc agactcccga atagctggga ttacagacag     1980

gcaccaccac acccagctaa tttttgtatt ttttgtagag acggggtttc gccaagttga     2040

ccagcccagt ttcaaactcc tgacctcagg tgatctgcct gccttggcat cccaaagtgc     2100

tgggattaca agaatgagcc accgtgcctg gcctatttta ttatattgta atatatttta     2160

ttatattagc caccatgcct gtcctatttt cttatgtttt aatatatttt aatatattac     2220

atgtgcagta attagattat catgggtgaa ctttatgagt gagtatcttg gtgatgactc     2280

ctcctgacca gcccaggacc agctttcttg tcaccttgag gtcccctcgc cccgtcacac     2340

cgttatgcat tactctgtgt ctactattat gtgtgcataa tttataccgt aaatgtttac     2400

tctttaaata gaaaaaaaaa aaaaaa                                          2426


<210>  53
<211>  1056
<212>  DNA
<213>  Homo sapiens

<400>  53
atggtgctgt cccaggatgg atctgtgcag tcagggtttc tcgctgaggg acatctggat       60

ggtcagccct tcctgcgcta tgacaggcag aaacgcaggg caaagcccca gggacagtgg      120

gcagaaaatg tcctgggagc taagacctgg gacacagaga ccgaggactt gacagagaat      180

gggcaagacc tcaggaggac cctgactcat atcaaggacc agaaaggagg cttgcattcc      240

ctccaggaga ttagggtctg tgagatccat gaagacagca gcaccagggg ctcccggcat      300

ttctactacg atggggagct cttcctctcc caaaacctgg agactcaaga atcgacagtg      360

ccccagtcct ccagagctca gaccttggct atgaacgtca caaatttctg gaaggaagat      420

gccatgaaga ccaagacaca ctatcgcgct atgcaggcag actgcctgca gaaactacag      480

cgatatctga aatccggggt ggccatcagg agaacagtgc cccccatggt gaatgtcacc      540

tgcagcgagg tctcagaggg caacatcacc gtgacatgca gggcttccag cttctatccc      600

cggaatatca cactgacctg gcgtcaggat ggggtatctt tgagccacaa cacccagcag      660

tggggggatg tcctgcctga tgggaatgga acctaccaga cctgggtggc caccaggatt      720

cgccaaggag aggagcagag gttcacctgc tacatggaac acagcgggaa tcacggcact      780

caccctgtgc cctctgggaa ggcgctggtg cttcagagtc aacggacaga ctttccatat      840

gtttctgctg ctatgccatg ttttgttatt attattattc tctgtgtccc ttgttgcaag      900

aagaaaacat cagcggcaga gggtccagag cttgtgagcc tgcaggtcct ggatcaacac      960

ccagttggga caggagacca cagggatgca gcacagctgg gatttcagcc tctgatgtca     1020

gctactgggt ccactggttc cactgagggc acctag                               1056


<210>  54
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
1               5                   10                  15      


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
            20                  25                  30          


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys 
        35                  40                  45              


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
    50                  55                  60                  


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
65                  70                  75                  80  


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
                85                  90                  95      


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
            100                 105                 110         


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
        115                 120                 125             


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
    130                 135                 140                 


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
145                 150                 155                 160 


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
                165                 170                 175     


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
            180                 185                 190         


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
        195                 200                 205             


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
    210                 215                 220                 


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
225                 230                 235                 240 


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
                245                 250                 255     


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln 
            260                 265                 270         


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
        275                 280                 285             


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
    290                 295                 300                 


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
305                 310                 315                 320 


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
                325                 330                 335     


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Thr 
            340                 345                 350     


<210>  55
<211>  2396
<212>  DNA
<213>  Homo sapiens

<400>  55
tggccctaag ttccgggcct cagttttcac tggataagcg gtcgctgagc ggggcgcagg       60

tgactaaatt tcgacggggt cttctcacgg gtttcattca gttggccact gctgagcagc      120

tgagaaggtg gcgacgtagg ggccatgggg ctgggccggg tcctgctgtt tctggccgtc      180

gccttccctt ttgcaccccc ggcagccgcc gctgagcccc acagtcttcg ttacaacctc      240

atggtgctgt cccaggatgg atctgtgcag tcagggtttc tcgctgaggg acatctggat      300

ggtcagccct tcctgcgcta tgacaggcag aaacgcaggg caaagcccca gggacagtgg      360

gcagaaaatg tcctgggagc taagacctgg gacacagaga ccgaggactt gacagagaat      420

gggcaagacc tcaggaggac cctgactcat atcaaggacc agaaaggagt gccccagtcc      480

tccagagctc agaccttggc tatgaacgtc acaaatttct ggaaggaaga tgccatgaag      540

accaagacac actatcgcgc tatgcaggca gactgcctgc agaaactaca gcgatatctg      600

aaatccgggg tggccatcag gagaacagtg ccccccatgg tgaatgtcac ctgcagcgag      660

gtctcagagg gcaacatcac cgtgacatgc agggcttcca gcttctatcc ccggaatatc      720

acactgacct ggcgtcagga tggggtatct ttgagccaca acacccagca gtggggggat      780

gtcctgcctg atgggaatgg aacctaccag acctgggtgg ccaccaggat tcgccaagga      840

gaggagcaga ggttcacctg ctacatggaa cacagcggga atcacggcac tcaccctgtg      900

ccctctggga aggcgctggt gcttcagagt caacggacag actttccata tgtttctgct      960

gctatgccat gttttgttat tattattatt ctctgtgtcc cttgttgcaa gaagaaaaca     1020

tcagcggcag agggtccaga gcttgtgagc ctgcaggtcc tggatcaaca cccagttggg     1080

acaggagacc acagggatgc agcacagctg ggatttcagc ctctgatgtc agctactggg     1140

tccactggtt ccactgaggg cacctagact ctacagccag gcggccagga ttcaactccc     1200

tgcctggatc tcaccagcac tttccctctg tttcctgacc tatgaaacag agaaaataac     1260

atcacttatt tattgttgtt ggatgctgca aagtgttagt aggtatgagg tgtttgctgc     1320

tctgccacgt agagagccag caaagggatc atgaccaact caacattcca ttggaggcta     1380

tatgatcaaa cagcaaattg tttatcatga atgcaggatg tgggcaaact cacgactgct     1440

cctgccaaca gaaggtttgc tgagggcatt cactccatgg tgctcattgg agttatctac     1500

tgggtcatct agagcctatt gtttgaggaa tgcagtctta caagcctact ctggacccag     1560

cagctgactc cttcttccac ccctcttctt gctatctcct ataccaataa atacgaaggg     1620

ctgtggaaga tcagagccct tgttcacgag aagcaagaag ccccctgacc ccttgttcca     1680

aatatactct tttgtctttc tctttattcc cacgttcgcc ctttgttcag tccaatacag     1740

ggttgtgggg cccttaacag tgccatatta attggtatca ttatttctgt tgtttttgtt     1800

tttgtttttg tttttgtttt tgagacagag tctcactctg tcacccaggc tgcagttcac     1860

tggtgtgatc tcagctcact gcaacctctg cctcccaggt tcaagcactt ctcgtacctc     1920

agactcccga atagctggga ttacagacag gcaccaccac acccagctaa tttttgtatt     1980

ttttgtagag acggggtttc gccaagttga ccagcccagt ttcaaactcc tgacctcagg     2040

tgatctgcct gccttggcat cccaaagtgc tgggattaca agaatgagcc accgtgcctg     2100

gcctatttta ttatattgta atatatttta ttatattagc caccatgcct gtcctatttt     2160

cttatgtttt aatatatttt aatatattac atgtgcagta attagattat catgggtgaa     2220

ctttatgagt gagtatcttg gtgatgactc ctcctgacca gcccaggacc agctttcttg     2280

tcaccttgag gtcccctcgc cccgtcacac cgttatgcat tactctgtgt ctactattat     2340

gtgtgcataa tttataccgt aaatgtttac tctttaaata gaaaaaaaaa aaaaaa         2396


<210>  56
<211>  1023
<212>  DNA
<213>  Homo sapiens

<400>  56
atggggctgg gccgggtcct gctgtttctg gccgtcgcct tcccttttgc acccccggca       60

gccgccgctg agccccacag tcttcgttac aacctcatgg tgctgtccca ggatggatct      120

gtgcagtcag ggtttctcgc tgagggacat ctggatggtc agcccttcct gcgctatgac      180

aggcagaaac gcagggcaaa gccccaggga cagtgggcag aaaatgtcct gggagctaag      240

acctgggaca cagagaccga ggacttgaca gagaatgggc aagacctcag gaggaccctg      300

actcatatca aggaccagaa aggagtgccc cagtcctcca gagctcagac cttggctatg      360

aacgtcacaa atttctggaa ggaagatgcc atgaagacca agacacacta tcgcgctatg      420

caggcagact gcctgcagaa actacagcga tatctgaaat ccggggtggc catcaggaga      480

acagtgcccc ccatggtgaa tgtcacctgc agcgaggtct cagagggcaa catcaccgtg      540

acatgcaggg cttccagctt ctatccccgg aatatcacac tgacctggcg tcaggatggg      600

gtatctttga gccacaacac ccagcagtgg ggggatgtcc tgcctgatgg gaatggaacc      660

taccagacct gggtggccac caggattcgc caaggagagg agcagaggtt cacctgctac      720

atggaacaca gcgggaatca cggcactcac cctgtgccct ctgggaaggc gctggtgctt      780

cagagtcaac ggacagactt tccatatgtt tctgctgcta tgccatgttt tgttattatt      840

attattctct gtgtcccttg ttgcaagaag aaaacatcag cggcagaggg tccagagctt      900

gtgagcctgc aggtcctgga tcaacaccca gttgggacag gagaccacag ggatgcagca      960

cagctgggat ttcagcctct gatgtcagct actgggtcca ctggttccac tgagggcacc     1020

tag                                                                   1023


<210>  57
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Val Pro Gln Ser 
            100                 105                 110         


Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu 
        115                 120                 125             


Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys 
    130                 135                 140                 


Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg 
145                 150                 155                 160 


Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly 
                165                 170                 175     


Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile 
            180                 185                 190         


Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln 
        195                 200                 205             


Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp 
    210                 215                 220                 


Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr 
225                 230                 235                 240 


Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser Gly Lys 
                245                 250                 255     


Ala Leu Val Leu Gln Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala 
            260                 265                 270         


Ala Met Pro Cys Phe Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys 
        275                 280                 285             


Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln 
    290                 295                 300                 


Val Leu Asp Gln His Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala 
305                 310                 315                 320 


Gln Leu Gly Phe Gln Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser 
                325                 330                 335     


Thr Glu Gly Thr 
            340 


<210>  58
<211>  2525
<212>  DNA
<213>  Homo sapiens

<400>  58
tggccctaag ttccgggcct cagttttcac tggataagcg gtcgctgagc ggggcgcagg       60

tgactaaatt tcgacggggt cttctcacgg gtttcattca gttggccact gctgagcagc      120

tgagaaggtg gcgacgtagg ggccatgggg ctgggccggg tcctgctgtt tctggccgtc      180

gccttccctt ttgcaccccc ggcagccgcc gctgagcccc acagtcttcg ttacaacctc      240

atggtgctgt cccaggatgg atctgtgcag tcagggtttc tcgctgaggg acatctggat      300

ggtcagccct tcctgcgcta tgacaggcag aaacgcaggg caaagcccca gggacagtgg      360

gcagaaaatg tcctgggagc taagacctgg gacacagaga ccgaggactt gacagagaat      420

gggcaagacc tcaggaggac cctgactcat atcaaggacc agaaaggagg cttgcattcc      480

ctccaggaga ttagggtctg tgagatccat gaagacagca gcaccagggg ctcccggcat      540

ttctactacg atggggagct cttcctctcc caaaacctgg agactcaaga atcgacagtg      600

ccccagtcct ccagagctca gaccttggct atgaacgtca caaatttctg gaaggaagat      660

gccatgaaga ccaagacaca ctatcgcgct atgcaggcag actgcctgca gaaactacag      720

cgatatctga aatccggggt ggccatcagg agaacagtgc cccccatggt gaatgtcacc      780

tgcagcgagg tctcagaggg caacatcacc gtgacatgca gggcttccag cttctatccc      840

cggaatatca cactgacctg gcgtcaggat ggggtatctt tgagccacaa cacccagcag      900

tggggggatg tcctgcctga tgggaatgga acctaccaga cctgggtggc caccaggatt      960

cgccaaggag aggagcagag gttcacctgc tacatggaac acagcgggaa tcacggcact     1020

caccctgtgc cctctgggaa ggcgctggtg cttcagagtc aacggacaga ctttccatat     1080

gtttctgctg ctatgccatg ttttgttatt attattattc tctgtgtccc ttgttgcaag     1140

aagaaaacat cagcggcaga gggtccagag cttgtgagcc tgcaggtcct ggatcaacac     1200

ccagttggga caggagacca cagggatgca gcacagctgg gatttcagcc tctgatgtca     1260

gctactgggt ccactggttc cactgagggc acctagactc tacagccagg cggccaggat     1320

tcaactccct gcctggatct caccagcact ttccctctgt ttcctgacct atgaaacaga     1380

gaaaataaca tcacttattt attgttgttg gatgctgcaa agtgttagta ggtatgaggt     1440

gtttgctgct ctgccacgta gagagccagc aaagggatca tgaccaactc aacattccat     1500

tggaggctat atgatcaaac agcaaattgt ttatcatgaa tgcaggatgt gggcaaactc     1560

acgactgctc ctgccaacag aaggtttgct gagggcattc actccatggt gctcattgga     1620

gttatctact gggtcatcta gagcctattg tttgaggaat gcagtcttac aagcctactc     1680

tggacccagc agctgactcc ttcttccacc cctcttcttg ctatctccta taccaataaa     1740

tacgaagggc tgtggaagat cagagccctt gttcacgaga agcaagaagc cccctgaccc     1800

cttgttccaa atatactctt ttgtctttct ctttattccc acgttcgccc tttgttcagt     1860

ccaatacagg gttgtggggc ccttaacagt gccatattaa ttggtatcat tatttctgtt     1920

gtttttgttt ttgtttttgt ttttgttttt gagacagagt ctcactctgt cacccaggct     1980

gcagttcact ggtgtgatct cagctcactg caacctctgc ctcccaggtt caagcacttc     2040

tcgtacctca gactcccgaa tagctgggat tacagacagg caccaccaca cccagctaat     2100

ttttgtattt tttgtagaga cggggtttcg ccaagttgac cagcccagtt tcaaactcct     2160

gacctcaggt gatctgcctg ccttggcatc ccaaagtgct gggattacaa gaatgagcca     2220

ccgtgcctgg cctattttat tatattgtaa tatattttat tatattagcc accatgcctg     2280

tcctattttc ttatgtttta atatatttta atatattaca tgtgcagtaa ttagattatc     2340

atgggtgaac tttatgagtg agtatcttgg tgatgactcc tcctgaccag cccaggacca     2400

gctttcttgt caccttgagg tcccctcgcc ccgtcacacc gttatgcatt actctgtgtc     2460

tactattatg tgtgcataat ttataccgta aatgtttact ctttaaatag aaaaaaaaaa     2520

aaaaa                                                                 2525


<210>  59
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  59
atggggctgg gccgggtcct gctgtttctg gccgtcgcct tcccttttgc acccccggca       60

gccgccgctg agccccacag tcttcgttac aacctcatgg tgctgtccca ggatggatct      120

gtgcagtcag ggtttctcgc tgagggacat ctggatggtc agcccttcct gcgctatgac      180

aggcagaaac gcagggcaaa gccccaggga cagtgggcag aaaatgtcct gggagctaag      240

acctgggaca cagagaccga ggacttgaca gagaatgggc aagacctcag gaggaccctg      300

actcatatca aggaccagaa aggaggcttg cattccctcc aggagattag ggtctgtgag      360

atccatgaag acagcagcac caggggctcc cggcatttct actacgatgg ggagctcttc      420

ctctcccaaa acctggagac tcaagaatcg acagtgcccc agtcctccag agctcagacc      480

ttggctatga acgtcacaaa tttctggaag gaagatgcca tgaagaccaa gacacactat      540

cgcgctatgc aggcagactg cctgcagaaa ctacagcgat atctgaaatc cggggtggcc      600

atcaggagaa cagtgccccc catggtgaat gtcacctgca gcgaggtctc agagggcaac      660

atcaccgtga catgcagggc ttccagcttc tatccccgga atatcacact gacctggcgt      720

caggatgggg tatctttgag ccacaacacc cagcagtggg gggatgtcct gcctgatggg      780

aatggaacct accagacctg ggtggccacc aggattcgcc aaggagagga gcagaggttc      840

acctgctaca tggaacacag cgggaatcac ggcactcacc ctgtgccctc tgggaaggcg      900

ctggtgcttc agagtcaacg gacagacttt ccatatgttt ctgctgctat gccatgtttt      960

gttattatta ttattctctg tgtcccttgt tgcaagaaga aaacatcagc ggcagagggt     1020

ccagagcttg tgagcctgca ggtcctggat caacacccag ttgggacagg agaccacagg     1080

gatgcagcac agctgggatt tcagcctctg atgtcagcta ctgggtccac tggttccact     1140

gagggcacct ag                                                         1152


<210>  60
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Thr 
    370                 375                 380             


<210>  61
<211>  2978
<212>  DNA
<213>  Homo sapiens

<400>  61
cgtcctatct gcagtcggct actttcagtg gcagaagagg ccacatctgc ttcctgtagg       60

ccctctgggc agaagcatgc gctggtgtct cctcctgatc tgggcccagg ggctgaggca      120

ggctcccctc gcctcaggaa tgatgacagg cacaatagaa acaacgggga acatttctgc      180

agagaaaggt ggctctatca tcttacaatg tcacctctcc tccaccacgg cacaagtgac      240

ccaggtcaac tgggagcagc aggaccagct tctggccatt tgtaatgctg acttggggtg      300

gcacatctcc ccatccttca aggatcgagt ggccccaggt cccggcctgg gcctcaccct      360

ccagtcgctg accgtgaacg atacagggga gtacttctgc atctatcaca cctaccctga      420

tgggacgtac actgggagaa tcttcctgga ggtcctagaa agctcagtgg ctgagcacgg      480

tgccaggttc cagattccat tgcttggagc catggccgcg acgctggtgg tcatctgcac      540

agcagtcatc gtggtggtcg cgttgactag aaagaagaaa gccctcagaa tccattctgt      600

ggaaggtgac ctcaggagaa aatcagctgg acaggaggaa tggagcccca gtgctccctc      660

acccccagga agctgtgtcc aggcagaagc tgcacctgct gggctctgtg gagagcagcg      720

gggagaggac tgtgccgagc tgcatgacta cttcaatgtc ctgagttaca gaagcctggg      780

taactgcagc ttcttcacag agactggtta gcaaccagag gcatcttctg gaagatacac      840

ttttgtcttt gctattatag atgaatatat aagcagctgt actctccatc agtgctgcgt      900

gtgtgtgtgt gtgtgtatgt gtgtgtgtgt tcagttgagt gaataaatgt catcctcttc      960

tccatcttca tttccttggc cttttcgttc tattccattt tgcattatgg caggcctagg     1020

gtgagtaacg tggatcttga tcataaatgc aaaattaaaa aatatcttga cctggtttta     1080

aatctggcag tttgagcaga tcctatgtct ctgagagaca cattcctcat aatggccagc     1140

attttgggct acaaggtttt gtggttgatg atgaggatgg catgactgca gagccatcct     1200

catctcattt tttcacgtca ttttcagtaa ctttcactca ttcaaaggca ggttataagt     1260

aagtcctggt agcagcctct atggggagat ttgagagtga ctaaatcttg gtatctgccc     1320

tcaagaactt acagttaaat ggggagacaa tgttgtcatg aaaaggtatt atagtaagga     1380

gagaaggaga catacacagg ccttcaggaa gagacgacag tttggggtga ggtagttggc     1440

ataggcttat ctgtgatgaa gtggcctggg agcaccaagg ggatgttgag gctagtctgg     1500

gaggagcagg agttttgtct agggaacttg taggaaattc ttggagctga aagtcccaca     1560

aagaaggccc tggcaccaag ggagtcagca aacttcagat tttattctct gggcaggcat     1620

ttcaagtttc cttttgctgt gacatactca tccattagac agcctgatac aggcctgtag     1680

cctcttccgg ccgtgtgtgc tggggaagcc ccaggaaacg cacatgccca cacagggagc     1740

caagtcgtag catttgggcc ttgatctacc ttttctgcat caatacactc ttgagccttt     1800

gaaaaaagaa cgtttcccac taaaaagaaa atgtggattt ttaaaatagg gactcttcct     1860

aggggaaaaa ggggggctgg gagtgataga gggtttaaaa aataaacacc ttcaaactaa     1920

cttcttcgaa cccttttatt cactccctga cgactttgtg ctggggttgg ggtaactgaa     1980

ccgcttattt ctgtttaatt gcattcaggc tggatcttag aagactttta tccttccacc     2040

atctctctca gaggaatgag cggggaggtt ggatttactg gtgactgatt ttctttcatg     2100

ggccaaggaa ctgaaagaga atgtgaagca aggttgtgtc ttgcgcatgg ttaaaaataa     2160

agcattgtcc tgcttcctaa gacttagact ggggttgaca attgttttag caacaagaca     2220

attcaactat ttctcctagg atttttatta ttattatttt ttcacttttc taccaaatgg     2280

gttacatagg aagaatgaac tgaaatctgt ccagagctcc aagtcctttg gaagaaagat     2340

tagatgaacg taaaaatgtt gttgtttgct gtggcagttt acagcatttt tcttgcaaaa     2400

ttagtgcaaa tctgttggaa atagaacaca attcacaaat tggaagtgaa ctaaaatgta     2460

atgacgaaaa gggagtagtg ttttgatttg gaggaggtgt atattcggca gaggttggac     2520

tgagagttgg gtgttattta acataattat ggtaattggg aaacatttat aaacactatt     2580

gggatggtga taaaatacaa aagggcctat agatgttaga aatgggtcag gttactgaaa     2640

tgggattcaa tttgaaaaaa atttttttaa atagaactca ctgaactaga ttctcctctg     2700

agaaccagag aagaccattt catagttgga ttcctggaga catgcgctat ccaccacgta     2760

gccactttcc acatgtggcc atcaaccact taagatgggg ttagtttaaa tcaagatgtg     2820

ctgttataat tggtataagc ataaaatcac actagattct ggagatttaa tatgaataat     2880

aagaatacta tttcagtagt tttggtatat tgtgtgtcaa aaatgataat attttggatg     2940

tattgggtga aataaaatat taacattaaa aaaaaaaa                             2978


<210>  62
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  62
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca       60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg      360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      420

ccattgcttg gagccatggc cgcgacgctg gtggtcatct gcacagcagt catcgtggtg      480

gtcgcgttga ctagaaagaa gaaagccctc agaatccatt ctgtggaagg tgacctcagg      540

agaaaatcag ctggacagga ggaatggagc cccagtgctc cctcaccccc aggaagctgt      600

gtccaggcag aagctgcacc tgctgggctc tgtggagagc agcggggaga ggactgtgcc      660

gagctgcatg actacttcaa tgtcctgagt tacagaagcc tgggtaactg cagcttcttc      720

acagagactg gttag                                                       735


<210>  63
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  64
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  64
actaagtatc tccactttca attctagatc aggaactgag gacatatcta aattttctag       60

ttttatagaa ggcttttatc cacaagaatc aagatcttcc ctctctgagc aggaatcctt      120

tgtgcattga agactttaga ttcctctctg cggtagacgt gcacttataa gtatttgatg      180

gggtggattc gtggtcggag gtctcgacac agctgggaga tgagtgaatt tcataattat      240

aacttggatc tgaagaagag tgatttttca acacgatggc aaaagcaaag atgtccagta      300

gtcaaaagca aatgtagaga aaatgcatct ccattttttt tctgctgctt catcgctgta      360

gccatgggaa tccgtttcat tattatggta acaatatgga gtgctgtatt cctaaactca      420

ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa      480

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      540

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      600

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      660

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      720

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      780

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtgtaaag atgatcaacc      840

atctcaataa aagccaggaa cagagaagag attacaccag cggtaacact gccaactgag      900

actaaaggaa acaaacaaaa acaggacaaa atgaccaaag actgtcagat ttcttagact      960

ccacaggacc aaaccataga acaatttcac tgcaaacatg catgattctc caagacaaaa     1020

gaagagagat cctaaaggca attcagatat ccccaaggct gcctctccca ccacaagccc     1080

agagtggatg ggctggggga ggggtgctgt tttaatttct aaaggtagga ccaacaccca     1140

ggggatcagt gaaggaagag aaggccagca gatcactgag agtgcaaccc caccctccac     1200

aggaaattgc ctcatgggca gggccacagc agagagacac agcatgggca gtgccttccc     1260

tgcctgtggg ggtcatgctg ccacttttaa tgggtcctcc acccaacggg gtcagggagg     1320

tggtgctgcc ccagtgggcc atgattatct taaaggcatt attctccagc cttaagtaag     1380

atcttaggac gtttcctttg ctatgatttg tacttgcttg agtcccatga ctgtttctct     1440

tcctctcttt cttccttttg gaatagtaat atccatccta tgtttgtccc actattgtat     1500

tttggaagca cataacttgt ttggtttcac aggttcacag ttaagaagga attttgcctc     1560

tgaataaata gaatcttgag tctcatgcaa aaaaaaaaaa aaaaaa                    1606


<210>  65
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  65
atggggtgga ttcgtggtcg gaggtctcga cacagctggg agatgagtga atttcataat       60

tataacttgg atctgaagaa gagtgatttt tcaacacgat ggcaaaagca aagatgtcca      120

gtagtcaaaa gcaaatgtag agaaaatgca tctccatttt ttttctgctg cttcatcgct      180

gtagccatgg gaatccgttt cattattatg gtaacaatat ggagtgctgt attcctaaac      240

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      300

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      360

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      420

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      480

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca      540

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata      600

gaaaactgtt caactccaaa tacgtacatc tgcatgcaaa ggactgtgta a               651


<210>  66
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Ile Pro 
145                 150                 155                 160 


Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn 
                165                 170                 175     


Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala 
            180                 185                 190         


Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr 
        195                 200                 205             


Ile Cys Met Gln Arg Thr Val 
    210                 215 


<210>  67
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
ccgggcttcc aataacatga ctcttctcga gaagagtcat gttattggaa gctttttg         58


<210>  68
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
ccggccggtc aacctaccaa tcaatctcga gattgattgg taggttgacc ggtttttg         58


<210>  69
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  69
ccggcccaag acaaatagtg agcaactcga gttgctcact atttgtcttg ggtttttg         58


<210>  70
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
ccgggccgag aacatgtctc tagaactcga gttctagaga catgttctcg gctttttg         58


<210>  71
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
ccggcgcaga ccaaagacta gagttctcga gaactctagt ctttggtctg cgtttttg         58


<210>  72
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
ccggatgata caagagagga tatttctcga gaaatatcct ctcttgtatc atttttttg        59


<210>  73
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
ccgggctttg ggcaagggct atttactcga gtaaatagcc cttgcccaaa gcttttttg        59


<210>  74
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
ccgggtactc atgcatggat ctttactcga gtaaagatcc atgcatgagt acttttttg        59


<210>  75
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  75
ccggatccat caatgggcat cttaactcga gttaagatgc ccattgatgg atttttttg        59


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  76
atccaggcag ggaattgaat c                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  77
tattccaggg atagaagcca g                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  78
tttctggtcc ttgatatgag c                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  79
ttcttacaac aacggacata g                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  80
atttcccagg acatcttctg c                                                 21


<210>  81
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  81
ccggccttgg ctatgaacgt cacaactcga gttgtgacgt tcatagccaa ggtttttg         58


<210>  82
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
ccggcagagt caacggacag actttctcga gaaagtctgt ccgttgactc tgtttttg         58


<210>  83
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
ccggctgtgt cccttgttgc aagaactcga gttcttgcaa caagggacac agtttttg         58


<210>  84
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
ccggcggaca gactttccat atgttctcga gaacatatgg aaagtctgtc cgtttttg         58


<210>  85
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
ccggaccgag gacttgacag agaatctcga gattctctgt caagtcctcg gttttttg         58


<210>  86
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
ccggctgtgt cccttgttgc aagaactcga gttcttgcaa caagggacac agtttttg         58


<210>  87
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
ccggcagaaa ctacagcgat atctgctcga gcagatatcg ctgtagtttc tgtttttg         58


<210>  88
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
ccgggctatc tcctatacca ataaactcga gtttattggt ataggagata gctttttg         58


<210>  89
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
ccggcggaca gactttccat atgttctcga gaacatatgg aaagtctgtc cgtttttg         58


<210>  90
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
ccgggatgca gcacagctgg gatttctcga gaaatcccag ctgtgctgca tctttttg         58


