                         SEQUENCE LISTING

<110>  Fondazione Telethon
 
<120>  Combined therapy for lysosomal storage disease

<130>  PCT 133819

<150>  US62/385,670
<151>  2016-09-09

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggtccgc gcggcgcggc gagcttgccc cgaggccccg gacctcggcg gctgctcctc       60

cccgtcgtcc tcccgctgct gctgctgctg ttgttggcgc cgccgggctc gggcgccggg      120

gccagccggc cgccccacct ggtcttcttg ctggcagacg acctaggctg gaacgacgtc      180

ggcttccacg gctcccgcat ccgcacgccg cacctggacg cgctggcggc cggcggggtg      240

ctcctggaca actactacac gcagccgctg tgcacgccgt cgcggagcca gctgctcact      300

ggccgctacc agatccgtac aggtttacag caccaaataa tctggccctg tcagcccagc      360

tgtgttcctc tggatgaaaa actcctgccc cagctcctaa aagaagcagg ttatactacc      420

catatggtcg gaaaatggca cctgggaatg taccggaaag aatgccttcc aacccgccga      480

ggatttgata cctactttgg atatctcctg ggtagtgaag attattattc ccatgaacgc      540

tgtacattaa ttgacgctct gaatgtcaca cgatgtgctc ttgattttcg agatggcgaa      600

gaagttgcaa caggatataa aaatatgtat tcaacaaaca tattcaccaa aagggctata      660

gccctcataa ctaaccatcc accagagaag cctctgtttc tctaccttgc tctccagtct      720

gtgcatgagc cccttcaggt ccctgaggaa tacttgaagc catatgactt tatccaagac      780

aagaacaggc atcactatgc aggaatggtg tcccttatgg atgaagcagt aggaaatgtc      840

actgcagctt taaaaagcag tgggctctgg aacaacacgg tgttcatctt ttctacagat      900

aacggagggc agactttggc agggggtaat aactggcccc ttcgaggaag aaaatggagc      960

ctgtgggaag gaggcgtccg aggggtgggc tttgtggcaa gccccttgct gaagcagaag     1020

ggcgtgaaga accgggagct catccacatc tctgactggc tgccaacact cgtgaagctg     1080

gccaggggac acaccaatgg cacaaagcct ctggatggct tcgacgtgtg gaaaaccatc     1140

agtgaaggaa gcccatcccc cagaattgag ctgctgcata atattgaccc gaacttcgtg     1200

gactcttcac cgtgtcccag gaacagcatg gctccagcaa aggatgactc ttctcttcca     1260

gaatattcag cctttaacac atctgtccat gctgcaatta gacatggaaa ttggaaactc     1320

ctcacgggct acccaggctg tggttactgg ttccctccac cgtctcaata caatgtttct     1380

gagataccct catcagaccc accaaccaag accctctggc tctttgatat tgatcgggac     1440

cctgaagaaa gacatgacct gtccagagaa tatcctcaca tcgtcacaaa gctcctgtcc     1500

cgcctacagt tctaccataa acactcagtc cccgtgtact tccctgcaca ggacccccgc     1560

tgtgatccca aggccactgg ggtgtggggc ccttggatgt ag                        1602


<210>  2
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  3
<211>  3214
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttaagctagc aggttaattt ttaaaaagca      240

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      300

ctcaggagca caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag      360

tggcccttgg cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa      420

cattccagat ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat      480

gcatgtataa tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa      540

ctttccctta aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc      600

tgctgcctct tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc      660

agcatggact taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag      720

ggtctggcag ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct      780

cttggccttg gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt      840

aatttataac taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga      900

tgttgctttc tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag      960

gttacaagac aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc     1020

ttgcgtttct gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca     1080

ggtgtccagg cccggagccg ccatgggtcc gcgcggcgcg gcgagcttgc cccgaggccc     1140

cggacctcgg cggctgctcc tccccgtcgt cctcccgctg ctgctgctgc tgttgttggc     1200

gccgccgggc tcgggcgccg gggccagccg gccgccccac ctggtcttct tgctggcaga     1260

cgacctaggc tggaacgacg tcggcttcca cggctcccgc atccgcacgc cgcacctgga     1320

cgcgctggcg gccggcgggg tgctcctgga caactactac acgcagccgc tgtgcacgcc     1380

gtcgcggagc cagctgctca ctggccgcta ccagatccgt acaggtttac agcaccaaat     1440

aatctggccc tgtcagccca gctgtgttcc tctggatgaa aaactcctgc cccagctcct     1500

aaaagaagca ggttatacta cccatatggt cggaaaatgg cacctgggaa tgtaccggaa     1560

agaatgcctt ccaacccgcc gaggatttga tacctacttt ggatatctcc tgggtagtga     1620

agattattat tcccatgaac gctgtacatt aattgacgct ctgaatgtca cacgatgtgc     1680

tcttgatttt cgagatggcg aagaagttgc aacaggatat aaaaatatgt attcaacaaa     1740

catattcacc aaaagggcta tagccctcat aactaaccat ccaccagaga agcctctgtt     1800

tctctacctt gctctccagt ctgtgcatga gccccttcag gtccctgagg aatacttgaa     1860

gccatatgac tttatccaag acaagaacag gcatcactat gcaggaatgg tgtcccttat     1920

ggatgaagca gtaggaaatg tcactgcagc tttaaaaagc agtgggctct ggaacaacac     1980

ggtgttcatc ttttctacag ataacggagg gcagactttg gcagggggta ataactggcc     2040

ccttcgagga agaaaatgga gcctgtggga aggaggcgtc cgaggggtgg gctttgtggc     2100

aagccccttg ctgaagcaga agggcgtgaa gaaccgggag ctcatccaca tctctgactg     2160

gctgccaaca ctcgtgaagc tggccagggg acacaccaat ggcacaaagc ctctggatgg     2220

cttcgacgtg tggaaaacca tcagtgaagg aagcccatcc cccagaattg agctgctgca     2280

taatattgac ccgaacttcg tggactcttc accgtgtccc aggaacagca tggctccagc     2340

aaaggatgac tcttctcttc cagaatattc agcctttaac acatctgtcc atgctgcaat     2400

tagacatgga aattggaaac tcctcacggg ctacccaggc tgtggttact ggttccctcc     2460

accgtctcaa tacaatgttt ctgagatacc ctcatcagac ccaccaacca agaccctctg     2520

gctctttgat attgatcggg accctgaaga aagacatgac ctgtccagag aatatcctca     2580

catcgtcaca aagctcctgt cccgcctaca gttctaccat aaacactcag tccccgtgta     2640

cttccctgca caggaccccc gctgtgatcc caaggccact ggggtgtggg gcccttggat     2700

gtagctcgaa tcaagcttat cgattctagt agatctgcct cgactgtgcc ttctagttgc     2760

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2820

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2880

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2940

catgctgggg actcgagtta agggcgaatt cccgataagg atcttcctag agcatggcta     3000

caattcgttg atctgaattt cgaccaccca taatacccat taccctggta gataagtagc     3060

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     3120

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     3180

cccgggcggc ctcagtgagc gagcgagcgc gcag                                 3214


<210>  4
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val Phe Leu Leu Ala 
1               5                   10                  15      


Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly Ser Arg Ile Arg 
            20                  25                  30          


Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val Leu Leu Asp Asn 
        35                  40                  45              


Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser Gln Leu Leu Thr 
    50                  55                  60                  


Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln Ile Ile Trp Pro 
65                  70                  75                  80  


Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu Leu Pro Gln Leu 
                85                  90                  95      


Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly Lys Trp His Leu 
            100                 105                 110         


Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg Gly Phe Asp Thr 
        115                 120                 125             


Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr Ser His Glu Arg 
    130                 135                 140                 


Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys Ala Leu Asp Phe 
145                 150                 155                 160 


Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn Met Tyr Ser Thr 
                165                 170                 175     


Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr Asn His Pro Pro 
            180                 185                 190         


Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser Val His Glu Pro 
        195                 200                 205             


Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp Phe Ile Gln Asp 
    210                 215                 220                 


Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu Met Asp Glu Ala 
225                 230                 235                 240 


Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly Leu Trp Asn Asn 
                245                 250                 255     


Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln Thr Leu Ala Gly 
            260                 265                 270         


Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser Leu Trp Glu Gly 
        275                 280                 285             


Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu Leu Lys Gln Lys 
    290                 295                 300                 


Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp Trp Leu Pro Thr 
305                 310                 315                 320 


Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr Lys Pro Leu Asp 
                325                 330                 335     


Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser Pro Ser Pro Arg 
            340                 345                 350         


Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val Asp Ser Ser Pro 
        355                 360                 365             


Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp Ser Ser Leu Pro 
    370                 375                 380                 


Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala Ile Arg His Gly 
385                 390                 395                 400 


Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly Tyr Trp Phe Pro 
                405                 410                 415     


Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser Ser Asp Pro Pro 
            420                 425                 430         


Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp Pro Glu Glu Arg 
        435                 440                 445             


His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr Lys Leu Leu Ser 
    450                 455                 460                 


Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val Tyr Phe Pro Ala 
465                 470                 475                 480 


Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val Trp Gly Pro Trp 
                485                 490                 495     


Met 
    


<210>  5
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  6
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  7
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctgggga                                         208


<210>  8
<211>  6472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttaagctagc aggttaattt ttaaaaagca      240

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      300

ctcaggagca caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag      360

tggcccttgg cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa      420

cattccagat ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat      480

gcatgtataa tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa      540

ctttccctta aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc      600

tgctgcctct tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc      660

agcatggact taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag      720

ggtctggcag ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct      780

cttggccttg gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt      840

aatttataac taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga      900

tgttgctttc tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag      960

gttacaagac aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc     1020

ttgcgtttct gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca     1080

ggtgtccagg cccggagccg ccatgggtcc gcgcggcgcg gcgagcttgc cccgaggccc     1140

cggacctcgg cggctgctcc tccccgtcgt cctcccgctg ctgctgctgc tgttgttggc     1200

gccgccgggc tcgggcgccg gggccagccg gccgccccac ctggtcttct tgctggcaga     1260

cgacctaggc tggaacgacg tcggcttcca cggctcccgc atccgcacgc cgcacctgga     1320

cgcgctggcg gccggcgggg tgctcctgga caactactac acgcagccgc tgtgcacgcc     1380

gtcgcggagc cagctgctca ctggccgcta ccagatccgt acaggtttac agcaccaaat     1440

aatctggccc tgtcagccca gctgtgttcc tctggatgaa aaactcctgc cccagctcct     1500

aaaagaagca ggttatacta cccatatggt cggaaaatgg cacctgggaa tgtaccggaa     1560

agaatgcctt ccaacccgcc gaggatttga tacctacttt ggatatctcc tgggtagtga     1620

agattattat tcccatgaac gctgtacatt aattgacgct ctgaatgtca cacgatgtgc     1680

tcttgatttt cgagatggcg aagaagttgc aacaggatat aaaaatatgt attcaacaaa     1740

catattcacc aaaagggcta tagccctcat aactaaccat ccaccagaga agcctctgtt     1800

tctctacctt gctctccagt ctgtgcatga gccccttcag gtccctgagg aatacttgaa     1860

gccatatgac tttatccaag acaagaacag gcatcactat gcaggaatgg tgtcccttat     1920

ggatgaagca gtaggaaatg tcactgcagc tttaaaaagc agtgggctct ggaacaacac     1980

ggtgttcatc ttttctacag ataacggagg gcagactttg gcagggggta ataactggcc     2040

ccttcgagga agaaaatgga gcctgtggga aggaggcgtc cgaggggtgg gctttgtggc     2100

aagccccttg ctgaagcaga agggcgtgaa gaaccgggag ctcatccaca tctctgactg     2160

gctgccaaca ctcgtgaagc tggccagggg acacaccaat ggcacaaagc ctctggatgg     2220

cttcgacgtg tggaaaacca tcagtgaagg aagcccatcc cccagaattg agctgctgca     2280

taatattgac ccgaacttcg tggactcttc accgtgtccc aggaacagca tggctccagc     2340

aaaggatgac tcttctcttc cagaatattc agcctttaac acatctgtcc atgctgcaat     2400

tagacatgga aattggaaac tcctcacggg ctacccaggc tgtggttact ggttccctcc     2460

accgtctcaa tacaatgttt ctgagatacc ctcatcagac ccaccaacca agaccctctg     2520

gctctttgat attgatcggg accctgaaga aagacatgac ctgtccagag aatatcctca     2580

catcgtcaca aagctcctgt cccgcctaca gttctaccat aaacactcag tccccgtgta     2640

cttccctgca caggaccccc gctgtgatcc caaggccact ggggtgtggg gcccttggat     2700

gtagctcgaa tcaagcttat cgattctagt agatctgcct cgactgtgcc ttctagttgc     2760

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2820

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2880

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2940

catgctgggg actcgagtta agggcgaatt cccgataagg atcttcctag agcatggcta     3000

caattcgttg atctgaattt cgaccaccca taatacccat taccctggta gataagtagc     3060

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     3120

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     3180

cccgggcggc ctcagtgagc gagcgagcgc gcagccttaa ttaacctaat tcactggccg     3240

tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag     3300

cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc     3360

aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg     3420

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     3480

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     3540

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     3600

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     3660

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     3720

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     3780

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaatc atgtgagcaa     3840

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     3900

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     3960

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4020

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4080

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4140

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4200

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4260

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4320

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     4380

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     4440

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     4500

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     4560

caaaaaggat cttcacctag atccttttga tcctccggcg ttcagcctgt gccacagccg     4620

acaggatggt gaccaccatt tgccccatat caccgtcggt actgatcccg tcgtcaataa     4680

accgaaccgc tacaccctga gcatcaaact cttttatcag ttggatcatg tcggcggtgt     4740

cgcggccaag acggtcgagc ttcttcacca gaatgacatc accttcctcc accttcatcc     4800

tcagcaaatc cagcccttcc cgatctgttg aactgccgga tgccttgtcg gtaaagatgc     4860

ggttagcttt tacccctgca tctttgagcg ctgaggtctg cctcgtgaag aaggtgttgc     4920

tgactcatac caggcctgaa tcgccccatc atccagccag aaagtgaggg agccacggtt     4980

gatgagagct ttgttgtagg tggaccagtt ggtgattttg aacttttgct ttgccacgga     5040

acggtctgcg ttgtcgggaa gatgcgtgat ctgatccttc aactcagcaa aagttcgatt     5100

tattcaacaa agccgccgtc ccgtcaagtc agcgtaatgc tctgccagtg ttacaaccaa     5160

ttaaccaatt ctgattagaa aaactcatcg agcatcaaat gaaactgcaa tttattcata     5220

tcaggattat caataccata tttttgaaaa agccgtttct gtaatgaagg agaaaactca     5280

ccgaggcagt tccataggat ggcaagatcc tggtatcggt ctgcgattcc gactcgtcca     5340

acatcaatac aacctattaa tttcccctcg tcaaaaataa ggttatcaag tgagaaatca     5400

ccatgagtga cgactgaatc cggtgagaat ggcaaaagct tatgcatttc tttccagact     5460

tgttcaacag gccagccatt acgctcgtca tcaaaatcac tcgcatcaac caaaccgtta     5520

ttcattcgtg attgcgcctg agcgagacga aatacgcgat cgctgttaaa aggacaatta     5580

caaacaggaa tcgaatgcaa ccggcgcagg aacactgcca gcgcatcaac aatattttca     5640

cctgaatcag gatattcttc taatacctgg aatgctgttt tcccggggat cgcagtggtg     5700

agtaaccatg catcatcagg agtacggata aaatgcttga tggtcggaag aggcataaat     5760

tccgtcagcc agtttagtct gaccatctca tctgtaacat cattggcaac gctacctttg     5820

ccatgtttca gaaacaactc tggcgcatcg ggcttcccat acaatcgata gattgtcgca     5880

cctgattgcc cgacattatc gcgagcccat ttatacccat ataaatcagc atccatgttg     5940

gaatttaatc gcggcctcga gcaagacgtt tcccgttgaa tatggctcat aacacccctt     6000

gtattactgt ttatgtaagc agacagtttt attgttcatg atgatatatt tttatcttgt     6060

gcaatgtaac atcagagatt ttgagacacc atgttctttc ctgcgttatc ccctgattct     6120

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     6180

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     6240

cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg     6300

ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta     6360

cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca     6420

ggaaacagct atgaccatga ttacgccaga tttaattaag gccttaatta gg             6472


<210>  9
<211>  5612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccagattta      240

attaaggctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc      300

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc      360

catcactagg ggttccttgt agttaatgat taacccgcca tgctacttat ctacgtagcc      420

atgctctagg aagatcggaa ttcgccctta agctagcagg ttaattttta aaaagcagtc      480

aaaagtccaa gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc      540

aggagcacaa acattccaga tccaggttaa tttttaaaaa gcagtcaaaa gtccaagtgg      600

cccttggcag catttactct ctctgtttgc tctggttaat aatctcagga gcacaaacat      660

tccagatccg gcgcgccagg gctggaagct acctttgaca tcatttcctc tgcgaatgca      720

tgtataattt ctacagaacc tattagaaag gatcacccag cctctgcttt tgtacaactt      780

tcccttaaaa aactgccaat tccactgctg tttggcccaa tagtgagaac tttttcctgc      840

tgcctcttgg tgcttttgcc tatggcccct attctgcctg ctgaagacac tcttgccagc      900

atggacttaa acccctccag ctctgacaat cctctttctc ttttgtttta catgaagggt      960

ctggcagcca aagcaatcac tcaaagttca aaccttatca ttttttgctt tgttcctctt     1020

ggccttggtt ttgtacatca gctttgaaaa taccatccca gggttaatgc tggggttaat     1080

ttataactaa gagtgctcta gttttgcaat acaggacatg ctataaaaat ggaaagatgt     1140

tgctttctga gagactgcag aagttggtcg tgaggcactg ggcaggtaag tatcaaggtt     1200

acaagacagg tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg     1260

cgtttctgat aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggt     1320

gtccaggcgg ccgccatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc     1380

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag     1440

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc     1500

gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac     1560

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag     1620

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc     1680

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc     1740

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc     1800

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc     1860

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg     1920

ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag     1980

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac     2040

gagctgtaca agtaataagc ttggatccaa tcaacctctg gattacaaaa tttgtgaaag     2100

attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat     2160

gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc     2220

ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg     2280

cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct     2340

ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct     2400

tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg     2460

gaagctgacg tcctttccat ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac     2520

gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct     2580

gccggctctg cggcctcttc cgcgtcttcg agatctgcct cgactgtgcc ttctagttgc     2640

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2700

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2760

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2820

catgctgggg actcgagtta agggcgaatt cccgattagg atcttcctag agcatggcta     2880

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     2940

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     3000

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagcc ttaattaacc     3060

taattcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact     3120

taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac     3180

cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg     3240

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     3300

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     3360

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     3420

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cccgatagac     3480

ggtttttcgc cctttgacgc tggagttcac gttcctcaat agtggactct tgttccaaac     3540

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga tttttccgat     3600

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     3660

aatattaacg tttataattt caggtggcat ctttcgggga aatgtgcgcg gaacccctat     3720

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     3780

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     3840

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     3900

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3960

tagtggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     4020

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     4080

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     4140

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     4200

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     4260

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     4320

cataccaaac gacgagcgtg acaccacgat gcctgtagta atggtaacaa cgttgcgcaa     4380

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     4440

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     4500

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     4560

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     4620

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     4680

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     4740

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     4800

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     4860

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     4920

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4980

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     5040

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     5100

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     5160

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     5220

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     5280

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     5340

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     5400

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     5460

cctggccttt tgctgcggtt ttgctcacat gttctttcct gcgttatccc ctgattctgt     5520

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     5580

gcgcagcgag tcagtgagcg aggaagcgga ag                                   5612


<210>  10
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa tttctacaga       60

acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta aaaaactgcc      120

aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct tggtgctttt      180

gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact taaacccctc      240

cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat      300

cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg gttttgtaca      360

tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac taagagtgct      420

ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc tgagaga         477


<210>  11
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  12
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
gcatgcttcc atgccaaggc ccacactgaa atgctcaaat gggagacaaa gagattaagc       60

tcttatgtaa aatttgctgt tttacataac tttaatgaat ggacaaagtc ttgtgcatgg      120

gggtgggggt ggggttagag gggaacagct ccagatggca aacatacgca agggatttag      180

tcaaacaact ttttggcaaa gatggtatga ttttgtaatg gggtaggaac caatgaaatg      240

cgaggtaagt atggttaatg atctacagtt attggttaaa gaagtatatt agagcgagtc      300

tttctgcaca cagatcacct ttcctatcaa cccc                                  334


<210>  13
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
cacggggttg gggttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg       60

ctctgggcgt ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac      120

gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct      180

tcctgctccg cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca      240

aacggaagcc gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc      300

agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc tcagcggggc gcgccgagag      360

cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt      420

cctgcccgcg cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc      480

cctcgttgac cgaatcaccg acctctctcc ccaggg                                516


<210>  14
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgt                        583


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
tctagttgcc agccatctgt tgt                                               23


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
tgggagtggc accttcca                                                     18


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
tcccccgtgc cttccttgac c                                                 21


