                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
       SONOVOL, INC.
       Gessner, Ryan Christopher
       Dayton, Paul Alexander
       Herlacher, Max Stephan
       Butler, James Owen
       Czernuszewicz, Tomasz Joseph
 
<120>  SYSTEM AND METHOD FOR NONINVASIVELY ASSESSING BIOENGINEERED 
       ORGANS

<130>  421/395 PCT

<150>  US 62/383,068
<151>  2016-09-02

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  6831
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (214)..(2430)

<400>  1
ccaggcccca ttgttcccgg tttccagcca tggctgccat tacctgacca gcgccacagc       60

cggtctctct gcaggcgccg ggagaagtga ccagagcaat ttctgctttt cacagggcgg      120

gtttctcaac ggtgacttgt gggcagtgcc ttctgctgag cgagtcatgg cccgaaggca      180

gaactaactg tgcctgcagt cttcactctc agg atg cag ccg agg tgg gcc caa       234
                                     Met Gln Pro Arg Trp Ala Gln          
                                     1               5                    

ggg gcc acg atg tgg ctt gga gtc ctg ctg acc ctt ctg ctc tgt tca        282
Gly Ala Thr Met Trp Leu Gly Val Leu Leu Thr Leu Leu Leu Cys Ser           
        10                  15                  20                        

agc ctt gag ggt caa gaa aac tct ttc aca atc aac agt gtt gac atg        330
Ser Leu Glu Gly Gln Glu Asn Ser Phe Thr Ile Asn Ser Val Asp Met           
    25                  30                  35                            

aag agc ctg ccg gac tgg acg gtg caa aat ggg aag aac ctg acc ctg        378
Lys Ser Leu Pro Asp Trp Thr Val Gln Asn Gly Lys Asn Leu Thr Leu           
40                  45                  50                  55            

cag tgc ttc gcg gat gtc agc acc acc tct cac gtc aag cct cag cac        426
Gln Cys Phe Ala Asp Val Ser Thr Thr Ser His Val Lys Pro Gln His           
                60                  65                  70                

cag atg ctg ttc tat aag gat gac gtg ctg ttt tac aac atc tcc tcc        474
Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser           
            75                  80                  85                    

atg aag agc aca gag agt tat ttt att cct gaa gtc cgg atc tat gac        522
Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp           
        90                  95                  100                       

tca ggg aca tat aaa tgt act gtg att gtg aac aac aaa gag aaa acc        570
Ser Gly Thr Tyr Lys Cys Thr Val Ile Val Asn Asn Lys Glu Lys Thr           
    105                 110                 115                           

act gca gag tac cag gtg ttg gtg gaa gga gtg ccc agt ccc agg gtg        618
Thr Ala Glu Tyr Gln Val Leu Val Glu Gly Val Pro Ser Pro Arg Val           
120                 125                 130                 135           

aca ctg gac aag aaa gag gcc atc caa ggt ggg atc gtg agg gtc aac        666
Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val Arg Val Asn           
                140                 145                 150               

tgt tct gtc cca gag gaa aag gcc cca ata cac ttc aca att gaa aaa        714
Cys Ser Val Pro Glu Glu Lys Ala Pro Ile His Phe Thr Ile Glu Lys           
            155                 160                 165                   

ctt gaa cta aat gaa aaa atg gtc aag ctg aaa aga gag aag aat tct        762
Leu Glu Leu Asn Glu Lys Met Val Lys Leu Lys Arg Glu Lys Asn Ser           
        170                 175                 180                       

cga gac cag aat ttt gtg ata ctg gaa ttc ccc gtt gag gaa cag gac        810
Arg Asp Gln Asn Phe Val Ile Leu Glu Phe Pro Val Glu Glu Gln Asp           
    185                 190                 195                           

cgc gtt tta tcc ttc cga tgt caa gct agg atc att tct ggg atc cat        858
Arg Val Leu Ser Phe Arg Cys Gln Ala Arg Ile Ile Ser Gly Ile His           
200                 205                 210                 215           

atg cag acc tca gaa tct acc aag agt gaa ctg gtc acc gtg acg gaa        906
Met Gln Thr Ser Glu Ser Thr Lys Ser Glu Leu Val Thr Val Thr Glu           
                220                 225                 230               

tcc ttc tct aca ccc aag ttc cac atc agc ccc acc gga atg atc atg        954
Ser Phe Ser Thr Pro Lys Phe His Ile Ser Pro Thr Gly Met Ile Met           
            235                 240                 245                   

gaa gga gct cag ctc cac att aag tgc acc att caa gtg act cac ctg       1002
Glu Gly Ala Gln Leu His Ile Lys Cys Thr Ile Gln Val Thr His Leu           
        250                 255                 260                       

gcc cag gag ttt cca gaa atc ata att cag aag gac aag gcg att gtg       1050
Ala Gln Glu Phe Pro Glu Ile Ile Ile Gln Lys Asp Lys Ala Ile Val           
    265                 270                 275                           

gcc cac aac aga cat ggc aac aag gct gtg tac tca gtc atg gcc atg       1098
Ala His Asn Arg His Gly Asn Lys Ala Val Tyr Ser Val Met Ala Met           
280                 285                 290                 295           

gtg gag cac agt ggc aac tac acg tgc aaa gtg gag tcc agc cgc ata       1146
Val Glu His Ser Gly Asn Tyr Thr Cys Lys Val Glu Ser Ser Arg Ile           
                300                 305                 310               

tcc aag gtc agc agc atc gtg gtc aac ata aca gaa cta ttt tcc aag       1194
Ser Lys Val Ser Ser Ile Val Val Asn Ile Thr Glu Leu Phe Ser Lys           
            315                 320                 325                   

ccc gaa ctg gaa tct tcc ttc aca cat ctg gac caa ggt gaa aga ctg       1242
Pro Glu Leu Glu Ser Ser Phe Thr His Leu Asp Gln Gly Glu Arg Leu           
        330                 335                 340                       

aac ctg tcc tgc tcc atc cca gga gca cct cca gcc aac ttc acc atc       1290
Asn Leu Ser Cys Ser Ile Pro Gly Ala Pro Pro Ala Asn Phe Thr Ile           
    345                 350                 355                           

cag aag gaa gat acg att gtg tca cag act caa gat ttc acc aag ata       1338
Gln Lys Glu Asp Thr Ile Val Ser Gln Thr Gln Asp Phe Thr Lys Ile           
360                 365                 370                 375           

gcc tca aag tcg gac agt ggg acg tat atc tgc act gca ggt att gac       1386
Ala Ser Lys Ser Asp Ser Gly Thr Tyr Ile Cys Thr Ala Gly Ile Asp           
                380                 385                 390               

aaa gtg gtc aag aaa agc aac aca gtc cag ata gtc gta tgt gaa atg       1434
Lys Val Val Lys Lys Ser Asn Thr Val Gln Ile Val Val Cys Glu Met           
            395                 400                 405                   

ctc tcc cag ccc agg att tct tat gat gcc cag ttt gag gtc ata aaa       1482
Leu Ser Gln Pro Arg Ile Ser Tyr Asp Ala Gln Phe Glu Val Ile Lys           
        410                 415                 420                       

gga cag acc atc gaa gtc cgt tgc gaa tcg atc agt gga act ttg cct       1530
Gly Gln Thr Ile Glu Val Arg Cys Glu Ser Ile Ser Gly Thr Leu Pro           
    425                 430                 435                           

att tct tac caa ctt tta aaa aca agt aaa gtt ttg gag aat agt acc       1578
Ile Ser Tyr Gln Leu Leu Lys Thr Ser Lys Val Leu Glu Asn Ser Thr           
440                 445                 450                 455           

aag aac tca aat gat cct gcg gta ttc aaa gac aac ccc act gaa gac       1626
Lys Asn Ser Asn Asp Pro Ala Val Phe Lys Asp Asn Pro Thr Glu Asp           
                460                 465                 470               

gtc gaa tac cag tgt gtt gca gat aat tgc cat tcc cat gcc aaa atg       1674
Val Glu Tyr Gln Cys Val Ala Asp Asn Cys His Ser His Ala Lys Met           
            475                 480                 485                   

tta agt gag gtt ctg agg gtg aag gtg ata gcc ccg gtg gat gag gtc       1722
Leu Ser Glu Val Leu Arg Val Lys Val Ile Ala Pro Val Asp Glu Val           
        490                 495                 500                       

cag att tct atc ctg tca agt aag gtg gtg gag tct gga gag gac att       1770
Gln Ile Ser Ile Leu Ser Ser Lys Val Val Glu Ser Gly Glu Asp Ile           
    505                 510                 515                           

gtg ctg caa tgt gct gtg aat gaa gga tct ggt ccc atc acc tat aag       1818
Val Leu Gln Cys Ala Val Asn Glu Gly Ser Gly Pro Ile Thr Tyr Lys           
520                 525                 530                 535           

ttt tac aga gaa aaa gag ggc aaa ccc ttc tat caa atg acc tca aat       1866
Phe Tyr Arg Glu Lys Glu Gly Lys Pro Phe Tyr Gln Met Thr Ser Asn           
                540                 545                 550               

gcc acc cag gca ttt tgg acc aag cag aag gct agc aag gaa cag gag       1914
Ala Thr Gln Ala Phe Trp Thr Lys Gln Lys Ala Ser Lys Glu Gln Glu           
            555                 560                 565                   

gga gag tat tac tgc aca gcc ttc aac aga gcc aac cac gcc tcc agt       1962
Gly Glu Tyr Tyr Cys Thr Ala Phe Asn Arg Ala Asn His Ala Ser Ser           
        570                 575                 580                       

gtc ccc aga agc aaa ata ctg aca gtc aga gtc att ctt gcc cca tgg       2010
Val Pro Arg Ser Lys Ile Leu Thr Val Arg Val Ile Leu Ala Pro Trp           
    585                 590                 595                           

aag aaa gga ctt att gca gtg gtt atc atc gga gtg atc att gct ctc       2058
Lys Lys Gly Leu Ile Ala Val Val Ile Ile Gly Val Ile Ile Ala Leu           
600                 605                 610                 615           

ttg atc att gcg gcc aaa tgt tat ttt ctg agg aaa gcc aag gcc aag       2106
Leu Ile Ile Ala Ala Lys Cys Tyr Phe Leu Arg Lys Ala Lys Ala Lys           
                620                 625                 630               

cag atg cca gtg gaa atg tcc agg cca gca gta cca ctt ctg aac tcc       2154
Gln Met Pro Val Glu Met Ser Arg Pro Ala Val Pro Leu Leu Asn Ser           
            635                 640                 645                   

aac aac gag aaa atg tca gat ccc aat atg gaa gct aac agt cat tac       2202
Asn Asn Glu Lys Met Ser Asp Pro Asn Met Glu Ala Asn Ser His Tyr           
        650                 655                 660                       

ggt cac aat gac gat gtc aga aac cat gca atg aaa cca ata aat gat       2250
Gly His Asn Asp Asp Val Arg Asn His Ala Met Lys Pro Ile Asn Asp           
    665                 670                 675                           

aat aaa gag cct ctg aac tca gac gtg cag tac acg gaa gtt caa gtg       2298
Asn Lys Glu Pro Leu Asn Ser Asp Val Gln Tyr Thr Glu Val Gln Val           
680                 685                 690                 695           

tcc tca gct gag tct cac aaa gat cta gga aag aag gac aca gag aca       2346
Ser Ser Ala Glu Ser His Lys Asp Leu Gly Lys Lys Asp Thr Glu Thr           
                700                 705                 710               

gtg tac agt gaa gtc cgg aaa gct gtc cct gat gcc gtg gaa agc aga       2394
Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp Ala Val Glu Ser Arg           
            715                 720                 725                   

tac tct aga acg gaa ggc tcc ctt gat gga act tag acagcaaggc            2440
Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr                               
        730                 735                                           

cagatgcaca tccctggaag gacatccatg ttccgagaag aacagataat ccctgtattt     2500

caagacctct gtgcacttat ttatgaacct gccctgctcc cacagaacac agcaattcct     2560

caggctaagc tgccggttct taaatccatc ctgctaagtt aatgttgggt agaaagagat     2620

acagaggggc tgttgaattt cccacatacc ctccttccac caagttggaa catccttgga     2680

aattggaaga gcacaagagg agatccaggg caaggccatt gggatattct gaaacttgaa     2740

tattttgttt tgtgcagaga taaagacctt ttccatgcac cctcatacac agaaaccaat     2800

tttctttttt atactcaatc atttctagcg catggcctgg ttagaggctg gttttttctc     2860

ttttcctttg gtccttcaaa ggcttgtagt tttggctagt ccttgttctt tggaaataca     2920

cagtgctgac cagacagcct ccccctgtcc cctctatgac ctcgccctcc acaaatggga     2980

aaaccagact acttgggagc accgcctgtg aaataccaac ctgaagacac cgttcattca     3040

ggcaacgcac aaaacagaaa atgaaggtgg aacaagcaca gatgttcttc aactgttttt     3100

gtctacactc tttctctttt cctctaccat gctgaaggct gaaagacagg aagatggtgc     3160

catcagcaaa tattattctt aattgaaaac ttgaaatgtg tatgtttctt actaattttt     3220

aaaaatgtat tccttgccag ggcaggcaag gtggctcacg cctgtaatcc cagcacttca     3280

ggaggctgag gtgggcggat cacctgaggt caggagtttg agaccagcct gatgaaaccc     3340

tgtctctact aaaaatacaa gaattagccg ggcgtggtgg cgcatgcctg tagtatcagc     3400

tactcaagag gctgaggtga gattatcgct tgaacccagg aaacggaggt tgtagtgagc     3460

ggagatcgcg ccactgcact ccagcctgag tgacagagtg agaatccatc tcaaaaaaaa     3520

caaaaaacaa aattgcttgc taaagaagtg gtctcctgag gtcttaagac attcctgaca     3580

gtgtcttgag tgggtgggag agaggctgct gtcattgcgc tgtggaattt cacagatgag     3640

aaccacgcct agccaaaatc acttttcctg tttgcctcag tgacacagct gcagggaccc     3700

tcgtggatgt tgtattaaat aaatttgacc tttgctcttt gcagatctgt gaaatgttgt     3760

cttctgaggg gccacatgca tctatagtgc tgaggactcc ttgggcctct gaagtcacag     3820

agagaaccga gcaggtctat gtttttgttt tgttgttttg agacggagat tcgctcttgt     3880

tgcccgggct ggactgcagc ggcgcaacct ctgctcactg caacctccgc ctcctgggtt     3940

caagcagttc tcctgtctca gcctcccgag tagctgggat tacaggcaca tgtcaccacg     4000

cctggctaat ttttgtattt ttagtagaga tggggtttca ccacgttggc caggctgatc     4060

tcgaatgcct gacctttggt gatctgcccg ccttgtcctc atgtgtgctc cacaggcctt     4120

tgggttggga ttgcaggcgt gagccaccat gcccagccta gactcttttg acaatatgat     4180

gaaagctgtt ggttcctttc cccaacacac acacaccgag ttgtatcacg aaaatgtcat     4240

acaatttcca ggttttctga gtggtgggct cagattgagg tcaaaggatc agacgacctc     4300

taacgacctt catgtctctg ttgatgatct ggggacagcc agatcccctg tgtccaggga     4360

gttccttagt cccttgccac caccagagaa gggcaattgc cacgggagct gcaaagaccc     4420

tattcctact cctggtgcct tacttatgca gcacgactga attttttgtt ttgttttgtt     4480

ttgttgagac aggggcttgc tctgttgccc aggctggagt gcagtggcac aacaatggct     4540

caccgcagcc tcgaacccct gggctcaagc gatcctccca tctcagcttc ctgggtagct     4600

gggaccagag gcgtgagccg ccatagctgg ctaattttta attttttttt tgcagagatg     4660

aggtttcacc atggtgccca ggctggtctc gaacttctgg gctcaagtga tcctccctcc     4720

ttggcctcgc aaagtgctgg gattgcaggc atgagccacc gcccccggcc tgtggagcac     4780

acatgagttt aaaattactt tcccttctgc ctatatttcc gaggaggaaa cttcatgcgc     4840

agggatcttt cttagtggat ttaatggcta aaaggtctgt ctgaatccag gacgctggct     4900

ttagccttcc tcggcagctg ccgtaacccc ggtgtctaaa cctgaagcat cccaggagca     4960

cccactccag gagttttctc ggccgcggaa ctcattagtt agagcgccct cttgtgttct     5020

catgtggtaa tcggtcactg aaggacttaa aatggtcctt agccaacaca cagtaaaact     5080

tttccctctt ctgaccccaa gaggtcagcc acccatttca tgagcatata ctggtcgccc     5140

catcagcgtt ctctgattgg ctaactgaac ccactccccg acctagactc aagacaggcg     5200

aagtgacgct taggtcaaca ttcactcact aaagcaacga ctgtcgggcg attttgtctc     5260

ccgctggttt tggaatggtg tctggagaca tttttggttg tcacagctgg gtgggtgtgc     5320

tcccggcatc tggtgggtag aaaccaagca tgctcctaaa catcctacag gcacagaacc     5380

gtctcccacg accaagcatg atcaagtccc aaatgccaat aatggccagg ttgagaaact     5440

ctgcacagaa gcatccagtt atttgtctgt ttgctcaaca agcttgtgct catcatgctc     5500

tgtgttcctg acgctgtgct gggtgttggc ggtgggaaga ttacaagagt cacatggcag     5560

ctgtcctcct ggaaggtaca acccagtaga gatgcagact aacagagagc caattacaaa     5620

gcagtgtgac aagcgtcatg gtggaaaatt aaaagctcaa acaagggcac atgggagggg     5680

cttccaacac agactttggg ggatccagga aggtctaaga ggaaagtggg tctcaccaaa     5740

gccttgacca taggcagagg gtaccagtgg aaaaggtggg gtgaagaaca ttgaggacaa     5800

aaggaagaag tgcaggaagg ccctgaggca agggagtggg gggtgccctg gagggatggc     5860

agcagggcag tctgtcagac ccaagtggcc tccagcccta gaagccaatt agtcctcctc     5920

aaaaagctgt cactgtcccc taagaattgc tgccaggctc ccactggcct gactcagtct     5980

ttgagagtct taaggaggag gtctctgaaa ggtacacacc aagaactctc cccagcacag     6040

ctgtttttaa gactctccac cagcgtcatt ggcgtgttgg gaagaaaccc tctgccacag     6100

aggccagctt cagcctttgc ctaacaccgc aagggcaaat ggaaaggtaa acgggaagga     6160

gatgtctccc cagcaggcta tttgaggaca gtcttccctg cagaagatct caacctgggg     6220

tccacagagt ggaaatgtta gagtagggag ctaggcaaac atgagcagga caggtgaggg     6280

cccccacagg aatgtcaggc taccatcagg tgatggtcag gtggttgtta aactgtctct     6340

gtaaaataat aattggttgc agccagctcc aagcaaggac agtctctcaa tagatacaaa     6400

acaccctgat ctggtgatca gccgcttccc gataagatct caggagctgg gcaagcagcc     6460

tggagcatgc gcaccaagag gcaaaatggc ggaatttaac cagtatatga cctaccttcc     6520

tctgggaacg cacgactggt aaggggaaaa atgcctcaag tgagcatgcg cgcaacttca     6580

gtaatcacac tgtgcatgcg accccttcca agtgctggca ggtcaccaca tacgcggaca     6640

gcctgctgca agggaagaat caggggagat gagacgtaaa tcccagaact atgccaaata     6700

cataaaaccc caagttaagg gtcaggcagg gcacttagat ctctcaagtt gcctgcctga     6760

cccaagtgta gtgtacttcc ttttgttcct gctctaaaac tttttaataa actctcactc     6820

ctgctctaaa a                                                          6831


<210>  2
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  3
<211>  3185
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (66)..(2558)

<400>  3
ggcagtgaga ctgtaagcag tctgggttgg gcagaaggca gaaaaccagc agagtcacag       60

aggag atg gcc aac tgc caa ata gcc atc ttg tac cag aga ttc cag aga      110
      Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg         
      1               5                   10                  15          

gtg gtc ttt gga att tcc caa ctc ctt tgc ttc agt gcc ctg atc tct        158
Val Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser           
                20                  25                  30                

gaa cta aca aac cag aaa gaa gtg gca gca tgg act tat cat tac agc        206
Glu Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser           
            35                  40                  45                    

aca aaa gca tac tca tgg aat att tcc cgt aaa tac tgc cag aat cgc        254
Thr Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg           
        50                  55                  60                        

tac aca gac tta gtg gcc atc cag aat aaa aat gaa att gat tac ctc        302
Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu           
    65                  70                  75                            

aat aag gtc cta ccc tac tac agc tcc tac tac tgg att ggg atc cga        350
Asn Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg           
80                  85                  90                  95            

aag aac aat aag aca tgg aca tgg gtg gga acc aaa aag gct ctc acc        398
Lys Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr           
                100                 105                 110               

aac gag gct gag aac tgg gct gat aat gaa cct aac aac aaa agg aac        446
Asn Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn           
            115                 120                 125                   

aac gag gac tgc gtg gag ata tac atc aag agt ccg tca gcc cct ggc        494
Asn Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly           
        130                 135                 140                       

aag tgg aat gat gag cac tgc ttg aag aaa aag cac gca ttg tgt tac        542
Lys Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr           
    145                 150                 155                           

aca gcc tcc tgc cag gac atg tcc tgc agc aaa caa gga gag tgc ctc        590
Thr Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu           
160                 165                 170                 175           

gag acc atc ggg aac tac acc tgc tcc tgt tac cct gga ttc tat ggg        638
Glu Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly           
                180                 185                 190               

cca gaa tgt gaa tac gtg aga gag tgt gga gaa ctt gag ctc cct caa        686
Pro Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln           
            195                 200                 205                   

cac gtg ctc atg aac tgc agc cac cct ctg gga aac ttc tct ttt aac        734
His Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn           
        210                 215                 220                       

tcg cag tgc agc ttc cac tgc act gac ggg tac caa gta aat ggg ccc        782
Ser Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro           
    225                 230                 235                           

agc aag ctg gaa tgc ttg gct tct gga atc tgg aca aat aag cct cca        830
Ser Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro           
240                 245                 250                 255           

cag tgt tta gct gcc cag tgc cca ccc ctg aag att cct gaa cga gga        878
Gln Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly           
                260                 265                 270               

aac atg acc tgc ctt cat tct gca aaa gca ttc cag cat cag tct agc        926
Asn Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser           
            275                 280                 285                   

tgc agc ttc agt tgt gaa gag gga ttt gca tta gtt gga ccg gaa gtg        974
Cys Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val           
        290                 295                 300                       

gtg caa tgc aca gcc tcg ggg gta tgg aca gcc cca gcc cca gtg tgt       1022
Val Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys           
    305                 310                 315                           

aaa gct gtg cag tgt cag cac ctg gaa gcc ccc agt gaa gga acc atg       1070
Lys Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met           
320                 325                 330                 335           

gac tgt gtt cat ccg ctc act gct ttt gcc tat ggc tcc agc tgt aaa       1118
Asp Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys           
                340                 345                 350               

ttt gag tgc cag ccc ggc tac aga gtg agg ggc ttg gac atg ctc cgc       1166
Phe Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg           
            355                 360                 365                   

tgc att gac tct gga cac tgg tct gca ccc ttg cca acc tgt gag gct       1214
Cys Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala           
        370                 375                 380                       

att tcg tgt gag ccg ctg gag agt cct gtc cac gga agc atg gat tgc       1262
Ile Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys           
    385                 390                 395                           

tct cca tcc ttg aga gcg ttt cag tat gac acc aac tgt agc ttc cgc       1310
Ser Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg           
400                 405                 410                 415           

tgt gct gaa ggt ttc atg ctg aga gga gcc gat ata gtt cgg tgt gat       1358
Cys Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp           
                420                 425                 430               

aac ttg gga cag tgg aca gca cca gcc cca gtc tgt caa gct ttg cag       1406
Asn Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln           
            435                 440                 445                   

tgc cag gat ctc cca gtt cca aat gag gcc cgg gtg aac tgc tcc cac       1454
Cys Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His           
        450                 455                 460                       

ccc ttc ggt gcc ttt agg tac cag tca gtc tgc agc ttc acc tgc aat       1502
Pro Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn           
    465                 470                 475                           

gaa ggc ttg ctc ctg gtg gga gca agt gtg cta cag tgc ttg gct act       1550
Glu Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr           
480                 485                 490                 495           

gga aac tgg aat tct gtt cct cca gaa tgc caa gcc att ccc tgc aca       1598
Gly Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr           
                500                 505                 510               

cct ttg cta agc cct cag aat gga aca atg acc tgt gtt caa cct ctt       1646
Pro Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu           
            515                 520                 525                   

gga agt tcc agt tat aaa tcc aca tgt caa ttc atc tgt gac gag gga       1694
Gly Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly           
        530                 535                 540                       

tat tct ttg tct gga cca gaa aga ttg gat tgt act cga tcg gga cgc       1742
Tyr Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg           
    545                 550                 555                           

tgg aca gac tcc cca cca atg tgt gaa gcc atc aag tgc cca gaa ctc       1790
Trp Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu           
560                 565                 570                 575           

ttt gcc cca gag cag ggc agc ctg gat tgt tct gac act cgt gga gaa       1838
Phe Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu           
                580                 585                 590               

ttc aat gtt ggc tcc acc tgc cat ttc tct tgt gac aac ggc ttt aag       1886
Phe Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys           
            595                 600                 605                   

ctg gag ggg ccc aat aat gtg gaa tgc aca act tct gga aga tgg tca       1934
Leu Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser           
        610                 615                 620                       

gct act cca cca acc tgc aaa ggc ata gca tca ctt cct act cca ggg       1982
Ala Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly           
    625                 630                 635                           

gtg caa tgt cca gcc ctc acc act cct ggg cag gga acc atg tac tgt       2030
Val Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys           
640                 645                 650                 655           

agg cat cat ccg gga acc ttt ggt ttt aat acc act tgt tac ttt ggc       2078
Arg His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly           
                660                 665                 670               

tgc aac gct gga ttc aca ctc ata gga gac agc act ctc agc tgc aga       2126
Cys Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg           
            675                 680                 685                   

cct tca gga caa tgg aca gca gta act cca gca tgc aga gct gtg aaa       2174
Pro Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys           
        690                 695                 700                       

tgc tca gaa cta cat gtt aat aag cca ata gcg atg aac tgc tcc aac       2222
Cys Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn           
    705                 710                 715                           

ctc tgg gga aac ttc agt tat gga tca atc tgc tct ttc cat tgt cta       2270
Leu Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu           
720                 725                 730                 735           

gag ggc cag tta ctt aat ggc tct gca caa aca gca tgc caa gag aat       2318
Glu Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn           
                740                 745                 750               

ggc cac tgg tca act acc gtg cca acc tgc caa gca gga cca ttg act       2366
Gly His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr           
            755                 760                 765                   

atc cag gaa gcc ctg act tac ttt ggt gga gcg gtg gct tct acg ata       2414
Ile Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile           
        770                 775                 780                       

ggt ctg ata atg ggt ggg acg ctc ctg gct ttg cta aga aag cgt ttc       2462
Gly Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe           
    785                 790                 795                           

aga caa aaa gat gat ggg aaa tgc ccc ttg aat cct cac agc cac cta       2510
Arg Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu           
800                 805                 810                 815           

gga aca tat gga gtt ttt aca aac gct gca ttt gac ccg agt cct taa       2558
Gly Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro               
                820                 825                 830               

ggtttccata aacacccatg aatcaaagac atggaattac cttagattag ctctggacca     2618

gcctgttgga cccgctctgg accaaccctg tttcctgagt ttgggattgt ggtacaatct     2678

caaattctca acctaccacc ccttcctgtc ccacctcttc tcttcctgta acacaagcca     2738

cagaagccag gagcaaatgt ttctgcagta gtctctgtgc tttgactcac ctgttacttg     2798

aaataccagt gaaccaaaga gactggagca tctgactcac aagaagacca gactgtggag     2858

aaataaaaat acctctttat tttttgattg aaggaaggtt ttctccactt tgttggaaag     2918

caggtggcat ctctaattgg aagaaattcc tgtagcatct tctggagtct ccagtggttg     2978

ctgttgatga ggcctcttgg acctctgctc tgaggcttcc agagagtcct ctggatggca     3038

ccagaggctg cagaaggcca agaatcaagc tagaaggcca catgtcaccg tggaccttcc     3098

tgccaccagt cactgtccct caaatgaccc aaagaccaat attcaaatgc gtaattaaaa     3158

gaattttccc caaaaaaaaa aaaaaaa                                         3185


<210>  4
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 
1               5                   10                  15      


Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 
            20                  25                  30          


Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr 
        35                  40                  45              


Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr 
    50                  55                  60                  


Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn 
65                  70                  75                  80  


Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys 
                85                  90                  95      


Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn 
            100                 105                 110         


Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn 
        115                 120                 125             


Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys 
    130                 135                 140                 


Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr 
145                 150                 155                 160 


Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu 
                165                 170                 175     


Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro 
            180                 185                 190         


Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His 
        195                 200                 205             


Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser 
    210                 215                 220                 


Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser 
225                 230                 235                 240 


Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln 
                245                 250                 255     


Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn 
            260                 265                 270         


Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys 
        275                 280                 285             


Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val 
    290                 295                 300                 


Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys 
305                 310                 315                 320 


Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp 
                325                 330                 335     


Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe 
            340                 345                 350         


Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys 
        355                 360                 365             


Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile 
    370                 375                 380                 


Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser 
385                 390                 395                 400 


Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys 
                405                 410                 415     


Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn 
            420                 425                 430         


Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys 
        435                 440                 445             


Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro 
    450                 455                 460                 


Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu 
465                 470                 475                 480 


Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly 
                485                 490                 495     


Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro 
            500                 505                 510         


Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly 
        515                 520                 525             


Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr 
    530                 535                 540                 


Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp 
545                 550                 555                 560 


Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe 
                565                 570                 575     


Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe 
            580                 585                 590         


Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu 
        595                 600                 605             


Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala 
    610                 615                 620                 


Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Val 
625                 630                 635                 640 


Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg 
                645                 650                 655     


His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys 
            660                 665                 670         


Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro 
        675                 680                 685             


Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys 
    690                 695                 700                 


Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu 
705                 710                 715                 720 


Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu 
                725                 730                 735     


Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly 
            740                 745                 750         


His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile 
        755                 760                 765             


Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly 
    770                 775                 780                 


Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg 
785                 790                 795                 800 


Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly 
                805                 810                 815     


Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 
            820                 825                 830 


<210>  5
<211>  3875
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (158)..(1990)

<400>  5
agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag       60

tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg aaagtatttc      120

aagcctaaac ctttgggtga aaagaactct tgaagtc atg att gct tca cag ttt       175
                                         Met Ile Ala Ser Gln Phe          
                                         1               5                

ctc tca gct ctc act ttg gtg ctt ctc att aaa gag agt gga gcc tgg        223
Leu Ser Ala Leu Thr Leu Val Leu Leu Ile Lys Glu Ser Gly Ala Trp           
            10                  15                  20                    

tct tac aac acc tcc acg gaa gct atg act tat gat gag gcc agt gct        271
Ser Tyr Asn Thr Ser Thr Glu Ala Met Thr Tyr Asp Glu Ala Ser Ala           
        25                  30                  35                        

tat tgt cag caa agg tac aca cac ctg gtt gca att caa aac aaa gaa        319
Tyr Cys Gln Gln Arg Tyr Thr His Leu Val Ala Ile Gln Asn Lys Glu           
    40                  45                  50                            

gag att gag tac cta aac tcc ata ttg agc tat tca cca agt tat tac        367
Glu Ile Glu Tyr Leu Asn Ser Ile Leu Ser Tyr Ser Pro Ser Tyr Tyr           
55                  60                  65                  70            

tgg att gga atc aga aaa gtc aac aat gtg tgg gtc tgg gta gga acc        415
Trp Ile Gly Ile Arg Lys Val Asn Asn Val Trp Val Trp Val Gly Thr           
                75                  80                  85                

cag aaa cct ctg aca gaa gaa gcc aag aac tgg gct cca ggt gaa ccc        463
Gln Lys Pro Leu Thr Glu Glu Ala Lys Asn Trp Ala Pro Gly Glu Pro           
            90                  95                  100                   

aac aat agg caa aaa gat gag gac tgc gtg gag atc tac atc aag aga        511
Asn Asn Arg Gln Lys Asp Glu Asp Cys Val Glu Ile Tyr Ile Lys Arg           
        105                 110                 115                       

gaa aaa gat gtg ggc atg tgg aat gat gag agg tgc agc aag aag aag        559
Glu Lys Asp Val Gly Met Trp Asn Asp Glu Arg Cys Ser Lys Lys Lys           
    120                 125                 130                           

ctt gcc cta tgc tac aca gct gcc tgt acc aat aca tcc tgc agt ggc        607
Leu Ala Leu Cys Tyr Thr Ala Ala Cys Thr Asn Thr Ser Cys Ser Gly           
135                 140                 145                 150           

cac ggt gaa tgt gta gag acc atc aat aat tac act tgc aag tgt gac        655
His Gly Glu Cys Val Glu Thr Ile Asn Asn Tyr Thr Cys Lys Cys Asp           
                155                 160                 165               

cct ggc ttc agt gga ctc aag tgt gag caa att gtg aac tgt aca gcc        703
Pro Gly Phe Ser Gly Leu Lys Cys Glu Gln Ile Val Asn Cys Thr Ala           
            170                 175                 180                   

ctg gaa tcc cct gag cat gga agc ctg gtt tgc agt cac cca ctg gga        751
Leu Glu Ser Pro Glu His Gly Ser Leu Val Cys Ser His Pro Leu Gly           
        185                 190                 195                       

aac ttc agc tac aat tct tcc tgc tct atc agc tgt gat agg ggt tac        799
Asn Phe Ser Tyr Asn Ser Ser Cys Ser Ile Ser Cys Asp Arg Gly Tyr           
    200                 205                 210                           

ctg cca agc agc atg gag acc atg cag tgt atg tcc tct gga gaa tgg        847
Leu Pro Ser Ser Met Glu Thr Met Gln Cys Met Ser Ser Gly Glu Trp           
215                 220                 225                 230           

agt gct cct att cca gcc tgc aat gtg gtt gag tgt gat gct gtg aca        895
Ser Ala Pro Ile Pro Ala Cys Asn Val Val Glu Cys Asp Ala Val Thr           
                235                 240                 245               

aat cca gcc aat ggg ttc gtg gaa tgt ttc caa aac cct gga agc ttc        943
Asn Pro Ala Asn Gly Phe Val Glu Cys Phe Gln Asn Pro Gly Ser Phe           
            250                 255                 260                   

cca tgg aac aca acc tgt aca ttt gac tgt gaa gaa gga ttt gaa cta        991
Pro Trp Asn Thr Thr Cys Thr Phe Asp Cys Glu Glu Gly Phe Glu Leu           
        265                 270                 275                       

atg gga gcc cag agc ctt cag tgt acc tca tct ggg aat tgg gac aac       1039
Met Gly Ala Gln Ser Leu Gln Cys Thr Ser Ser Gly Asn Trp Asp Asn           
    280                 285                 290                           

gag aag cca acg tgt aaa gct gtg aca tgc agg gcc gtc cgc cag cct       1087
Glu Lys Pro Thr Cys Lys Ala Val Thr Cys Arg Ala Val Arg Gln Pro           
295                 300                 305                 310           

cag aat ggc tct gtg agg tgc agc cat tcc cct gct gga gag ttc acc       1135
Gln Asn Gly Ser Val Arg Cys Ser His Ser Pro Ala Gly Glu Phe Thr           
                315                 320                 325               

ttc aaa tca tcc tgc aac ttc acc tgt gag gaa ggc ttc atg ttg cag       1183
Phe Lys Ser Ser Cys Asn Phe Thr Cys Glu Glu Gly Phe Met Leu Gln           
            330                 335                 340                   

gga cca gcc cag gtt gaa tgc acc act caa ggg cag tgg aca cag caa       1231
Gly Pro Ala Gln Val Glu Cys Thr Thr Gln Gly Gln Trp Thr Gln Gln           
        345                 350                 355                       

atc cca gtt tgt gaa gct ttc cag tgc aca gcc ttg tcc aac ccc gag       1279
Ile Pro Val Cys Glu Ala Phe Gln Cys Thr Ala Leu Ser Asn Pro Glu           
    360                 365                 370                           

cga ggc tac atg aat tgt ctt cct agt gct tct ggc agt ttc cgt tat       1327
Arg Gly Tyr Met Asn Cys Leu Pro Ser Ala Ser Gly Ser Phe Arg Tyr           
375                 380                 385                 390           

ggg tcc agc tgt gag ttc tcc tgt gag cag ggt ttt gtg ttg aag gga       1375
Gly Ser Ser Cys Glu Phe Ser Cys Glu Gln Gly Phe Val Leu Lys Gly           
                395                 400                 405               

tcc aaa agg ctc caa tgt ggc ccc aca ggg gag tgg gac aac gag aag       1423
Ser Lys Arg Leu Gln Cys Gly Pro Thr Gly Glu Trp Asp Asn Glu Lys           
            410                 415                 420                   

ccc aca tgt gaa gct gtg aga tgc gat gct gtc cac cag ccc ccg aag       1471
Pro Thr Cys Glu Ala Val Arg Cys Asp Ala Val His Gln Pro Pro Lys           
        425                 430                 435                       

ggt ttg gtg agg tgt gct cat tcc cct att gga gaa ttc acc tac aag       1519
Gly Leu Val Arg Cys Ala His Ser Pro Ile Gly Glu Phe Thr Tyr Lys           
    440                 445                 450                           

tcc tct tgt gcc ttc agc tgt gag gag gga ttt gaa tta cat gga tca       1567
Ser Ser Cys Ala Phe Ser Cys Glu Glu Gly Phe Glu Leu His Gly Ser           
455                 460                 465                 470           

act caa ctt gag tgc aca tct cag gga caa tgg aca gaa gag gtt cct       1615
Thr Gln Leu Glu Cys Thr Ser Gln Gly Gln Trp Thr Glu Glu Val Pro           
                475                 480                 485               

tcc tgc caa gtg gta aaa tgt tca agc ctg gca gtt ccg gga aag atc       1663
Ser Cys Gln Val Val Lys Cys Ser Ser Leu Ala Val Pro Gly Lys Ile           
            490                 495                 500                   

aac atg agc tgc agt ggg gag ccc gtg ttt ggc act gtg tgc aag ttc       1711
Asn Met Ser Cys Ser Gly Glu Pro Val Phe Gly Thr Val Cys Lys Phe           
        505                 510                 515                       

gcc tgt cct gaa gga tgg acg ctc aat ggc tct gca gct cgg aca tgt       1759
Ala Cys Pro Glu Gly Trp Thr Leu Asn Gly Ser Ala Ala Arg Thr Cys           
    520                 525                 530                           

gga gcc aca gga cac tgg tct ggc ctg cta cct acc tgt gaa gct ccc       1807
Gly Ala Thr Gly His Trp Ser Gly Leu Leu Pro Thr Cys Glu Ala Pro           
535                 540                 545                 550           

act gag tcc aac att ccc ttg gta gct gga ctt tct gct gct gga ctc       1855
Thr Glu Ser Asn Ile Pro Leu Val Ala Gly Leu Ser Ala Ala Gly Leu           
                555                 560                 565               

tcc ctc ctg aca tta gca cca ttt ctc ctc tgg ctt cgg aaa tgc tta       1903
Ser Leu Leu Thr Leu Ala Pro Phe Leu Leu Trp Leu Arg Lys Cys Leu           
            570                 575                 580                   

cgg aaa gca aag aaa ttt gtt cct gcc agc agc tgc caa agc ctt gaa       1951
Arg Lys Ala Lys Lys Phe Val Pro Ala Ser Ser Cys Gln Ser Leu Glu           
        585                 590                 595                       

tca gat gga agc tac caa aag cct tct tac atc ctt taa gttcaaaaga        2000
Ser Asp Gly Ser Tyr Gln Lys Pro Ser Tyr Ile Leu                           
    600                 605                 610                           

atcagaaaca ggtgcatctg gggaactaga gggatacact gaagttaaca gagacagata     2060

actctcctcg ggtctctggc ccttcttgcc tactatgcca gatgccttta tggctgaaac     2120

cgcaacaccc atcaccactt caatagatca aagtccagca ggcaaggacg gccttcaact     2180

gaaaagactc agtgttccct ttcctactct caggatcaag aaagtgttgg ctaatgaagg     2240

gaaaggatat tttcttccaa gcaaaggtga agagaccaag actctgaaat ctcagaattc     2300

cttttctaac tctcccttgc tcgctgtaaa atcttggcac agaaacacaa tattttgtgg     2360

ctttctttct tttgcccttc acagtgtttc gacagctgat tacacagttg ctgtcataag     2420

aatgaataat aattatccag agtttagagg aaaaaaatga ctaaaaatat tataacttaa     2480

aaaaatgaca gatgttgaat gcccacaggc aaatgcatgg agggttgtta atggtgcaaa     2540

tcctactgaa tgctctgtgc gagggttact atgcacaatt taatcacttt catccctatg     2600

ggattcagtg cttcttaaag agttcttaag gattgtgata tttttacttg cattgaatat     2660

attataatct tccatacttc ttcattcaat acaagtgtgg tagggactta aaaaacttgt     2720

aaatgctgtc aactatgata tggtaaaagt tacttattct agattacccc ctcattgttt     2780

attaacaaat tatgttacat ctgttttaaa tttatttcaa aaagggaaac tattgtcccc     2840

tagcaaggca tgatgttaac cagaataaag ttctgagtgt ttttactaca gttgtttttt     2900

gaaaacatgg tagaattgga gagtaaaaac tgaatggaag gtttgtatat tgtcagatat     2960

tttttcagaa atatgtggtt tccacgatga aaaacttcca tgaggccaaa cgttttgaac     3020

taataaaagc ataaatgcaa acacacaaag gtataatttt atgaatgtct ttgttggaaa     3080

agaatacaga aagatggatg tgctttgcat tcctacaaag atgtttgtca gatatgatat     3140

gtaaacataa ttcttgtata ttatggaaga ttttaaattc acaatagaaa ctcaccatgt     3200

aaaagagtca tctggtagat ttttaacgaa tgaagatgtc taatagttat tccctatttg     3260

ttttcttctg tatgttaggg tgctctggaa gagaggaatg cctgtgtgag caagcattta     3320

tgtttattta taagcagatt taacaattcc aaaggaatct ccagttttca gttgatcact     3380

ggcaatgaaa aattctcagt cagtaattgc caaagctgct ctagccttga ggagtgtgag     3440

aatcaaaact ctcctacact tccattaact tagcatgtgt tgaaaaaaaa gtttcagaga     3500

agttctggct gaacactggc aacaacaaag ccaacagtca aaacagagat gtgataagga     3560

tcagaacagc agaggttctt ttaaaggggc agaaaaactc tgggaaataa gagagaacaa     3620

ctactgtgat caggctatgt atggaataca gtgttatttt ctttgaaatt gtttaagtgt     3680

tgtaaatatt tatgtaaact gcattagaaa ttagctgtgt gaaataccag tgtggtttgt     3740

gtttgagttt tattgagaat tttaaattat aacttaaaat attttataat ttttaaagta     3800

tatatttatt taagcttatg tcagacctat ttgacataac actataaagg ttgacaataa     3860

atgtgcttat gttta                                                      3875


<210>  6
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Ala Ser Gln Phe Leu Ser Ala Leu Thr Leu Val Leu Leu Ile 
1               5                   10                  15      


Lys Glu Ser Gly Ala Trp Ser Tyr Asn Thr Ser Thr Glu Ala Met Thr 
            20                  25                  30          


Tyr Asp Glu Ala Ser Ala Tyr Cys Gln Gln Arg Tyr Thr His Leu Val 
        35                  40                  45              


Ala Ile Gln Asn Lys Glu Glu Ile Glu Tyr Leu Asn Ser Ile Leu Ser 
    50                  55                  60                  


Tyr Ser Pro Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Val Asn Asn Val 
65                  70                  75                  80  


Trp Val Trp Val Gly Thr Gln Lys Pro Leu Thr Glu Glu Ala Lys Asn 
                85                  90                  95      


Trp Ala Pro Gly Glu Pro Asn Asn Arg Gln Lys Asp Glu Asp Cys Val 
            100                 105                 110         


Glu Ile Tyr Ile Lys Arg Glu Lys Asp Val Gly Met Trp Asn Asp Glu 
        115                 120                 125             


Arg Cys Ser Lys Lys Lys Leu Ala Leu Cys Tyr Thr Ala Ala Cys Thr 
    130                 135                 140                 


Asn Thr Ser Cys Ser Gly His Gly Glu Cys Val Glu Thr Ile Asn Asn 
145                 150                 155                 160 


Tyr Thr Cys Lys Cys Asp Pro Gly Phe Ser Gly Leu Lys Cys Glu Gln 
                165                 170                 175     


Ile Val Asn Cys Thr Ala Leu Glu Ser Pro Glu His Gly Ser Leu Val 
            180                 185                 190         


Cys Ser His Pro Leu Gly Asn Phe Ser Tyr Asn Ser Ser Cys Ser Ile 
        195                 200                 205             


Ser Cys Asp Arg Gly Tyr Leu Pro Ser Ser Met Glu Thr Met Gln Cys 
    210                 215                 220                 


Met Ser Ser Gly Glu Trp Ser Ala Pro Ile Pro Ala Cys Asn Val Val 
225                 230                 235                 240 


Glu Cys Asp Ala Val Thr Asn Pro Ala Asn Gly Phe Val Glu Cys Phe 
                245                 250                 255     


Gln Asn Pro Gly Ser Phe Pro Trp Asn Thr Thr Cys Thr Phe Asp Cys 
            260                 265                 270         


Glu Glu Gly Phe Glu Leu Met Gly Ala Gln Ser Leu Gln Cys Thr Ser 
        275                 280                 285             


Ser Gly Asn Trp Asp Asn Glu Lys Pro Thr Cys Lys Ala Val Thr Cys 
    290                 295                 300                 


Arg Ala Val Arg Gln Pro Gln Asn Gly Ser Val Arg Cys Ser His Ser 
305                 310                 315                 320 


Pro Ala Gly Glu Phe Thr Phe Lys Ser Ser Cys Asn Phe Thr Cys Glu 
                325                 330                 335     


Glu Gly Phe Met Leu Gln Gly Pro Ala Gln Val Glu Cys Thr Thr Gln 
            340                 345                 350         


Gly Gln Trp Thr Gln Gln Ile Pro Val Cys Glu Ala Phe Gln Cys Thr 
        355                 360                 365             


Ala Leu Ser Asn Pro Glu Arg Gly Tyr Met Asn Cys Leu Pro Ser Ala 
    370                 375                 380                 


Ser Gly Ser Phe Arg Tyr Gly Ser Ser Cys Glu Phe Ser Cys Glu Gln 
385                 390                 395                 400 


Gly Phe Val Leu Lys Gly Ser Lys Arg Leu Gln Cys Gly Pro Thr Gly 
                405                 410                 415     


Glu Trp Asp Asn Glu Lys Pro Thr Cys Glu Ala Val Arg Cys Asp Ala 
            420                 425                 430         


Val His Gln Pro Pro Lys Gly Leu Val Arg Cys Ala His Ser Pro Ile 
        435                 440                 445             


Gly Glu Phe Thr Tyr Lys Ser Ser Cys Ala Phe Ser Cys Glu Glu Gly 
    450                 455                 460                 


Phe Glu Leu His Gly Ser Thr Gln Leu Glu Cys Thr Ser Gln Gly Gln 
465                 470                 475                 480 


Trp Thr Glu Glu Val Pro Ser Cys Gln Val Val Lys Cys Ser Ser Leu 
                485                 490                 495     


Ala Val Pro Gly Lys Ile Asn Met Ser Cys Ser Gly Glu Pro Val Phe 
            500                 505                 510         


Gly Thr Val Cys Lys Phe Ala Cys Pro Glu Gly Trp Thr Leu Asn Gly 
        515                 520                 525             


Ser Ala Ala Arg Thr Cys Gly Ala Thr Gly His Trp Ser Gly Leu Leu 
    530                 535                 540                 


Pro Thr Cys Glu Ala Pro Thr Glu Ser Asn Ile Pro Leu Val Ala Gly 
545                 550                 555                 560 


Leu Ser Ala Ala Gly Leu Ser Leu Leu Thr Leu Ala Pro Phe Leu Leu 
                565                 570                 575     


Trp Leu Arg Lys Cys Leu Arg Lys Ala Lys Lys Phe Val Pro Ala Ser 
            580                 585                 590         


Ser Cys Gln Ser Leu Glu Ser Asp Gly Ser Tyr Gln Lys Pro Ser Tyr 
        595                 600                 605             


Ile Leu 
    610 


<210>  7
<211>  6055
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (303)..(4373)

<400>  7
actgagtccc gggaccccgg gagagcggtc aatgtgtggt cgctgcgttt cctctgcctg       60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta      120

ccggcacccg cagacgcccc tgcagccgcg gtcggcgccc gggctcccta gccctgtgcg      180

ctcaactgtc ctgcgctgcg gggtgccgcg agttccacct ccgcgcctcc ttctctagac      240

aggcgctggg agaaagaacc ggctcccgag ttctgggcat ttcgcccggc tcgaggtgca      300

gg atg cag agc aag gtg ctg ctg gcc gtc gcc ctg tgg ctc tgc gtg         347
   Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val            
   1               5                   10                  15             

gag acc cgg gcc gcc tct gtg ggt ttg cct agt gtt tct ctt gat ctg        395
Glu Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu           
                20                  25                  30                

ccc agg ctc agc ata caa aaa gac ata ctt aca att aag gct aat aca        443
Pro Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr           
            35                  40                  45                    

act ctt caa att act tgc agg gga cag agg gac ttg gac tgg ctt tgg        491
Thr Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp           
        50                  55                  60                        

ccc aat aat cag agt ggc agt gag caa agg gtg gag gtg act gag tgc        539
Pro Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys           
    65                  70                  75                            

agc gat ggc ctc ttc tgt aag aca ctc aca att cca aaa gtg atc gga        587
Ser Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly           
80                  85                  90                  95            

aat gac act gga gcc tac aag tgc ttc tac cgg gaa act gac ttg gcc        635
Asn Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala           
                100                 105                 110               

tcg gtc att tat gtc tat gtt caa gat tac aga tct cca ttt att gct        683
Ser Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala           
            115                 120                 125                   

tct gtt agt gac caa cat gga gtc gtg tac att act gag aac aaa aac        731
Ser Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn           
        130                 135                 140                       

aaa act gtg gtg att cca tgt ctc ggg tcc att tca aat ctc aac gtg        779
Lys Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val           
    145                 150                 155                           

tca ctt tgt gca aga tac cca gaa aag aga ttt gtt cct gat ggt aac        827
Ser Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn           
160                 165                 170                 175           

aga att tcc tgg gac agc aag aag ggc ttt act att ccc agc tac atg        875
Arg Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met           
                180                 185                 190               

atc agc tat gct ggc atg gtc ttc tgt gaa gca aaa att aat gat gaa        923
Ile Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu           
            195                 200                 205                   

agt tac cag tct att atg tac ata gtt gtc gtt gta ggg tat agg att        971
Ser Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile           
        210                 215                 220                       

tat gat gtg gtt ctg agt ccg tct cat gga att gaa cta tct gtt gga       1019
Tyr Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly           
    225                 230                 235                           

gaa aag ctt gtc tta aat tgt aca gca aga act gaa cta aat gtg ggg       1067
Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly           
240                 245                 250                 255           

att gac ttc aac tgg gaa tac cct tct tcg aag cat cag cat aag aaa       1115
Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys           
                260                 265                 270               

ctt gta aac cga gac cta aaa acc cag tct ggg agt gag atg aag aaa       1163
Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys           
            275                 280                 285                   

ttt ttg agc acc tta act ata gat ggt gta acc cgg agt gac caa gga       1211
Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly           
        290                 295                 300                       

ttg tac acc tgt gca gca tcc agt ggg ctg atg acc aag aag aac agc       1259
Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser           
    305                 310                 315                           

aca ttt gtc agg gtc cat gaa aaa cct ttt gtt gct ttt gga agt ggc       1307
Thr Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly           
320                 325                 330                 335           

atg gaa tct ctg gtg gaa gcc acg gtg ggg gag cgt gtc aga atc cct       1355
Met Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro           
                340                 345                 350               

gcg aag tac ctt ggt tac cca ccc cca gaa ata aaa tgg tat aaa aat       1403
Ala Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn           
            355                 360                 365                   

gga ata ccc ctt gag tcc aat cac aca att aaa gcg ggg cat gta ctg       1451
Gly Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu           
        370                 375                 380                       

acg att atg gaa gtg agt gaa aga gac aca gga aat tac act gtc atc       1499
Thr Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile           
    385                 390                 395                           

ctt acc aat ccc att tca aag gag aag cag agc cat gtg gtc tct ctg       1547
Leu Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu           
400                 405                 410                 415           

gtt gtg tat gtc cca ccc cag att ggt gag aaa tct cta atc tct cct       1595
Val Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro           
                420                 425                 430               

gtg gat tcc tac cag tac ggc acc act caa acg ctg aca tgt acg gtc       1643
Val Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val           
            435                 440                 445                   

tat gcc att cct ccc ccg cat cac atc cac tgg tat tgg cag ttg gag       1691
Tyr Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu           
        450                 455                 460                       

gaa gag tgc gcc aac gag ccc agc caa gct gtc tca gtg aca aac cca       1739
Glu Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro           
    465                 470                 475                           

tac cct tgt gaa gaa tgg aga agt gtg gag gac ttc cag gga gga aat       1787
Tyr Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn           
480                 485                 490                 495           

aaa att gaa gtt aat aaa aat caa ttt gct cta att gaa gga aaa aac       1835
Lys Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn           
                500                 505                 510               

aaa act gta agt acc ctt gtt atc caa gcg gca aat gtg tca gct ttg       1883
Lys Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu           
            515                 520                 525                   

tac aaa tgt gaa gcg gtc aac aaa gtc ggg aga gga gag agg gtg atc       1931
Tyr Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile           
        530                 535                 540                       

tcc ttc cac gtg acc agg ggt cct gaa att act ttg caa cct gac atg       1979
Ser Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met           
    545                 550                 555                           

cag ccc act gag cag gag agc gtg tct ttg tgg tgc act gca gac aga       2027
Gln Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg           
560                 565                 570                 575           

tct acg ttt gag aac ctc aca tgg tac aag ctt ggc cca cag cct ctg       2075
Ser Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu           
                580                 585                 590               

cca atc cat gtg gga gag ttg ccc aca cct gtt tgc aag aac ttg gat       2123
Pro Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp           
            595                 600                 605                   

act ctt tgg aaa ttg aat gcc acc atg ttc tct aat agc aca aat gac       2171
Thr Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp           
        610                 615                 620                       

att ttg atc atg gag ctt aag aat gca tcc ttg cag gac caa gga gac       2219
Ile Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp           
    625                 630                 635                           

tat gtc tgc ctt gct caa gac agg aag acc aag aaa aga cat tgc gtg       2267
Tyr Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val           
640                 645                 650                 655           

gtc agg cag ctc aca gtc cta gag cgt gtg gca ccc acg atc aca gga       2315
Val Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly           
                660                 665                 670               

aac ctg gag aat cag acg aca agt att ggg gaa agc atc gaa gtc tca       2363
Asn Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser           
            675                 680                 685                   

tgc acg gca tct ggg aat ccc cct cca cag atc atg tgg ttt aaa gat       2411
Cys Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp           
        690                 695                 700                       

aat gag acc ctt gta gaa gac tca ggc att gta ttg aag gat ggg aac       2459
Asn Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn           
    705                 710                 715                           

cgg aac ctc act atc cgc aga gtg agg aag gag gac gaa ggc ctc tac       2507
Arg Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr           
720                 725                 730                 735           

acc tgc cag gca tgc agt gtt ctt ggc tgt gca aaa gtg gag gca ttt       2555
Thr Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe           
                740                 745                 750               

ttc ata ata gaa ggt gcc cag gaa aag acg aac ttg gaa atc att att       2603
Phe Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile           
            755                 760                 765                   

cta gta ggc acg gcg gtg att gcc atg ttc ttc tgg cta ctt ctt gtc       2651
Leu Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val           
        770                 775                 780                       

atc atc cta cgg acc gtt aag cgg gcc aat gga ggg gaa ctg aag aca       2699
Ile Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr           
    785                 790                 795                           

ggc tac ttg tcc atc gtc atg gat cca gat gaa ctc cca ttg gat gaa       2747
Gly Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu           
800                 805                 810                 815           

cat tgt gaa cga ctg cct tat gat gcc agc aaa tgg gaa ttc ccc aga       2795
His Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg           
                820                 825                 830               

gac cgg ctg aag cta ggt aag cct ctt ggc cgt ggt gcc ttt ggc caa       2843
Asp Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln           
            835                 840                 845                   

gtg att gaa gca gat gcc ttt gga att gac aag aca gca act tgc agg       2891
Val Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg           
        850                 855                 860                       

aca gta gca gtc aaa atg ttg aaa gaa gga gca aca cac agt gag cat       2939
Thr Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His           
    865                 870                 875                           

cga gct ctc atg tct gaa ctc aag atc ctc att cat att ggt cac cat       2987
Arg Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His           
880                 885                 890                 895           

ctc aat gtg gtc aac ctt cta ggt gcc tgt acc aag cca gga ggg cca       3035
Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro           
                900                 905                 910               

ctc atg gtg att gtg gaa ttc tgc aaa ttt gga aac ctg tcc act tac       3083
Leu Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr           
            915                 920                 925                   

ctg agg agc aag aga aat gaa ttt gtc ccc tac aag acc aaa ggg gca       3131
Leu Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala           
        930                 935                 940                       

cga ttc cgt caa ggg aaa gac tac gtt gga gca atc cct gtg gat ctg       3179
Arg Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu           
    945                 950                 955                           

aaa cgg cgc ttg gac agc atc acc agt agc cag agc tca gcc agc tct       3227
Lys Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser           
960                 965                 970                 975           

gga ttt gtg gag gag aag tcc ctc agt gat gta gaa gaa gag gaa gct       3275
Gly Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala           
                980                 985                 990               

cct gaa gat ctg tat aag gac ttc ctg  acc ttg gag cat ctc  atc tgt     3323
Pro Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys         
            995                 1000                 1005                 

tac agc ttc  caa gtg gct aag ggc  atg gag ttc ttg gca  tcg cga        3368
Tyr Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg            
        1010                 1015                 1020                    

aag tgt atc  cac agg gac ctg gcg  gca cga aat atc ctc  tta tcg        3413
Lys Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser            
        1025                 1030                 1035                    

gag aag aac  gtg gtt aaa atc tgt  gac ttt ggc ttg gcc  cgg gat        3458
Glu Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp            
        1040                 1045                 1050                    

att tat aaa  gat cca gat tat gtc  aga aaa gga gat gct  cgc ctc        3503
Ile Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu            
        1055                 1060                 1065                    

cct ttg aaa  tgg atg gcc cca gaa  aca att ttt gac aga  gtg tac        3548
Pro Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr            
        1070                 1075                 1080                    

aca atc cag  agt gac gtc tgg tct  ttt ggt gtt ttg ctg  tgg gaa        3593
Thr Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu            
        1085                 1090                 1095                    

ata ttt tcc  tta ggt gct tct cca  tat cct ggg gta aag  att gat        3638
Ile Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp            
        1100                 1105                 1110                    

gaa gaa ttt  tgt agg cga ttg aaa  gaa gga act aga atg  agg gcc        3683
Glu Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala            
        1115                 1120                 1125                    

cct gat tat  act aca cca gaa atg  tac cag acc atg ctg  gac tgc        3728
Pro Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys            
        1130                 1135                 1140                    

tgg cac ggg  gag ccc agt cag aga  ccc acg ttt tca gag  ttg gtg        3773
Trp His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val            
        1145                 1150                 1155                    

gaa cat ttg  gga aat ctc ttg caa  gct aat gct cag cag  gat ggc        3818
Glu His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly            
        1160                 1165                 1170                    

aaa gac tac  att gtt ctt ccg ata  tca gag act ttg agc  atg gaa        3863
Lys Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu            
        1175                 1180                 1185                    

gag gat tct  gga ctc tct ctg cct  acc tca cct gtt tcc  tgt atg        3908
Glu Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met            
        1190                 1195                 1200                    

gag gag gag  gaa gta tgt gac ccc  aaa ttc cat tat gac  aac aca        3953
Glu Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr            
        1205                 1210                 1215                    

gca gga atc  agt cag tat ctg cag  aac agt aag cga aag  agc cgg        3998
Ala Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg            
        1220                 1225                 1230                    

cct gtg agt  gta aaa aca ttt gaa  gat atc ccg tta gaa  gaa cca        4043
Pro Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro            
        1235                 1240                 1245                    

gaa gta aaa  gta atc cca gat gac  aac cag acg gac agt  ggt atg        4088
Glu Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met            
        1250                 1255                 1260                    

gtt ctt gcc  tca gaa gag ctg aaa  act ttg gaa gac aga  acc aaa        4133
Val Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys            
        1265                 1270                 1275                    

tta tct cca  tct ttt ggt gga atg  gtg ccc agc aaa agc  agg gag        4178
Leu Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu            
        1280                 1285                 1290                    

tct gtg gca  tct gaa ggc tca aac  cag aca agc ggc tac  cag tcc        4223
Ser Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser            
        1295                 1300                 1305                    

gga tat cac  tcc gat gac aca gac  acc acc gtg tac tcc  agt gag        4268
Gly Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu            
        1310                 1315                 1320                    

gaa gca gaa  ctt tta aag ctg ata  gag att gga gtg caa  acc ggt        4313
Glu Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly            
        1325                 1330                 1335                    

agc aca gcc  cag att ctc cag cct  gac tcg ggg acc aca  ctg agc        4358
Ser Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser            
        1340                 1345                 1350                    

tct cct cct  gtt taa aaggaagcat ccacaccccc aactcctgga catcacatga      4413
Ser Pro Pro  Val                                                          
        1355                                                              

gaggtgctgc tcagattttc aagtgttgtt ctttccacca gcaggaagta gccgcatttg     4473

attttcattt cgacaacaga aaaaggacct cggactgcag ggagccagtc ttctaggcat     4533

atcctggaag aggcttgtga cccaagaatg tgtctgtgtc ttctcccagt gttgacctga     4593

tcctcttttt cattcattta aaaagcattt atcatgcccc ctgctgcggg tctcaccatg     4653

ggtttagaac aaagacgttc aagaaatggc cccatcctca aagaagtagc agtacctggg     4713

gagctgacac ttctgtaaaa ctagaagata aaccaggcaa tgtaagtgtt cgaggtgttg     4773

aagatgggaa ggatttgcag ggctgagtct atccaagagg ctttgtttag gacgtgggtc     4833

ccaagccaag ccttaagtgt ggaattcgga ttgatagaaa ggaagactaa cgttaccttg     4893

ctttggagag tactggagcc tgcaaatgca ttgtgtttgc tctggtggag gtgggcatgg     4953

ggtctgttct gaaatgtaaa gggttcagac ggggtttctg gttttagaag gttgcgtgtt     5013

cttcgagttg ggctaaagta gagttcgttg tgctgtttct gactcctaat gagagttcct     5073

tccagaccgt tacgtgtctc ctggccaagc cccaggaagg aaatgatgca gctctggctc     5133

cttgtctccc aggctgatcc tttattcaga ataccacaaa gaaaggacat tcagctcaag     5193

gctccctgcc gtgttgaaga gttctgactg cacaaaccag cttctggttt cttctggaat     5253

gaataccctc atatctgtcc tgatgtgata tgtctgagac tgaatgcggg aggttcaatg     5313

tgaagctgtg tgtggtgtca aagtttcagg aaggatttta cccttttgtt cttccccctg     5373

tccccaaccc actctcaccc cgcaacccat cagtatttta gttatttggc ctctactcca     5433

gtaaacctga ttgggtttgt tcactctctg aatgattatt agccagactt caaaattatt     5493

ttatagccca aattataaca tctattgtat tatttagact tttaacatat agagctattt     5553

ctactgattt ttgcccttgt tctgtccttt ttttcaaaaa agaaaatgtg ttttttgttt     5613

ggtaccatag tgtgaaatgc tgggaacaat gactataaga catgctatgg cacatatatt     5673

tatagtctgt ttatgtagaa acaaatgtaa tatattaaag ccttatatat aatgaacttt     5733

gtactattca cattttgtat cagtattatg tagcataaca aaggtcataa tgctttcagc     5793

aattgatgtc attttattaa agaacattga aaaacttgaa ggaatccctt tgcaaggttg     5853

cattactgta cccatcattt ctaaaatgga agagggggtg gctgggcaca gtggccgaca     5913

cctaaaaacc cagcactttg gggggccaag gtgggaggat cgcttgagcc caggagttca     5973

agaccagtct ggccaacatg gtcagattcc atctcaaaga aaaaaggtaa aaataaaata     6033

aaatggagaa gaaggaatca ga                                              6055


<210>  8
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


