                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
      THE GENERAL HOSPITAL CORPORATION
      THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120> COMPOSITIONS AND METHODS FOR TREATING NEOPLASIAS

<130> 167741.015801/PCT

<140> PCT/US2017/049829
<141> 2017-09-01

<150> 62/383,111
<151> 2016-09-02

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 226
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210> 2
<211> 229
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210> 3
<211> 659
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210> 4
<211> 2611
<212> DNA
<213> Homo sapiens

<400> 4
aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa       60

gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat      120

ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca      180

gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca      240

gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa      300

actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat      360

agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga      420

aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga      480

aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc      540

aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag      600

tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc      660

tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa      720

acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca      780

gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct      840

gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg      900

gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga      960

taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat     1020

agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa     1080

gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac     1140

agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt     1200

gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc     1260

tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc     1320

agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga     1380

aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt     1440

gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc     1500

catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa     1560

gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta     1620

catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca     1680

gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca     1740

gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa     1800

agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg     1860

ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag     1920

caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat     1980

gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct     2040

ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga     2100

gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga     2160

tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc     2220

aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac     2280

tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga     2340

tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa     2400

gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa     2460

aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg     2520

tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga     2580

taaaataaaa ttactagaaa gcttgaaagt c                                    2611


<210> 5
<211> 454
<212> PRT
<213> Homo sapiens

<400> 5
Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210> 6
<211> 2121
<212> DNA
<213> Homo sapiens

<400> 6
ctgctcgcgg ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa       60

gggcagggct tctcagaggc ttggcgggaa aaaagaacgg agggagggat cgcgctgagt      120

ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga      180

gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg      240

cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg      300

cttgatcccc caggccagcg gtccgcaacc cttgccgcat ccacgaaact ttgcccatag      360

cagcgggcgg gcactttgca ctggaactta caacacccga gcaaggacgc gactctcccg      420

acgcggggag gctattctgc ccatttgggg acacttcccc gccgctgcca ggacccgctt      480

ctctgaaagg ctctccttgc agctgcttag acgctggatt tttttcgggt agtggaaaac      540

cagcagcctc ccgcgacgat gcccctcaac gttagcttca ccaacaggaa ctatgacctc      600

gactacgact cggtgcagcc gtatttctac tgcgacgagg aggagaactt ctaccagcag      660

cagcagcaga gcgagctgca gcccccggcg cccagcgagg atatctggaa gaaattcgag      720

ctgctgccca ccccgcccct gtcccctagc cgccgctccg ggctctgctc gccctcctac      780

gttgcggtca cacccttctc ccttcgggga gacaacgacg gcggtggcgg gagcttctcc      840

acggccgacc agctggagat ggtgaccgag ctgctgggag gagacatggt gaaccagagt      900

ttcatctgcg acccggacga cgagaccttc atcaaaaaca tcatcatcca ggactgtatg      960

tggagcggct tctcggccgc cgccaagctc gtctcagaga agctggcctc ctaccaggct     1020

gcgcgcaaag acagcggcag cccgaacccc gcccgcggcc acagcgtctg ctccacctcc     1080

agcttgtacc tgcaggatct gagcgccgcc gcctcagagt gcatcgaccc ctcggtggtc     1140

ttcccctacc ctctcaacga cagcagctcg cccaagtcct gcgcctcgca agactccagc     1200

gccttctctc cgtcctcgga ttctctgctc tcctcgacgg agtcctcccc gcagggcagc     1260

cccgagcccc tggtgctcca tgaggagaca ccgcccacca ccagcagcga ctctgaggag     1320

gaacaagaag atgaggaaga aatcgatgtt gtttctgtgg aaaagaggca ggctcctggc     1380

aaaaggtcag agtctggatc accttctgct ggaggccaca gcaaacctcc tcacagccca     1440

ctggtcctca agaggtgcca cgtctccaca catcagcaca actacgcagc gcctccctcc     1500

actcggaagg actatcctgc tgccaagagg gtcaagttgg acagtgtcag agtcctgaga     1560

cagatcagca acaaccgaaa atgcaccagc cccaggtcct cggacaccga ggagaatgtc     1620

aagaggcgaa cacacaacgt cttggagcgc cagaggagga acgagctaaa acggagcttt     1680

tttgccctgc gtgaccagat cccggagttg gaaaacaatg aaaaggcccc caaggtagtt     1740

atccttaaaa aagccacagc atacatcctg tccgtccaag cagaggagca aaagctcatt     1800

tctgaagagg acttgttgcg gaaacgacga gaacagttga aacacaaact tgaacagcta     1860

cggaactctt gtgcgtaagg aaaagtaagg aaaacgattc cttctaacag aaatgtcctg     1920

agcaatcacc tatgaacttg tttcaaatgc atgatcaaat gcaacctcac aaccttggct     1980

gagtcttgag actgaaagat ttagccataa tgtaaactgc ctcaaattgg actttgggca     2040

taaaagaact tttttatgct taccatcttt tttttttctt taacagattt gtatttaaga     2100

attgttttta aaaaatttta a                                               2121


<210> 7
<211> 2555
<212> PRT
<213> Homo sapiens

<400> 7
Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210> 8
<211> 9322
<212> DNA
<213> Homo sapiens

<400> 8
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gctcccagcc cggtgagacc tgcctgaatg gcgggaagtg tgaagcggcc      120

aatggcacgg aggcctgcgt ctgtggcggg gccttcgtgg gcccgcgatg ccaggacccc      180

aacccgtgcc tcagcacccc ctgcaagaac gccgggacat gccacgtggt ggaccgcaga      240

ggcgtggcag actatgcctg cagctgtgcc ctgggcttct ctgggcccct ctgcctgaca      300

cccctggaca atgcctgcct caccaacccc tgccgcaacg ggggcacctg cgacctgctc      360

acgctgacgg agtacaagtg ccgctgcccg cccggctggt cagggaaatc gtgccagcag      420

gctgacccgt gcgcctccaa cccctgcgcc aacggtggcc agtgcctgcc cttcgaggcc      480

tcctacatct gccactgccc acccagcttc catggcccca cctgccggca ggatgtcaac      540

gagtgtggcc agaagcccgg gctttgccgc cacggaggca cctgccacaa cgaggtcggc      600

tcctaccgct gcgtctgccg cgccacccac actggcccca actgcgagcg gccctacgtg      660

ccctgcagcc cctcgccctg ccagaacggg ggcacctgcc gccccacggg cgacgtcacc      720

cacgagtgtg cctgcctgcc aggcttcacc ggccagaact gtgaggaaaa tatcgacgat      780

tgtccaggaa acaactgcaa gaacgggggt gcctgtgtgg acggcgtgaa cacctacaac      840

tgccgctgcc cgccagagtg gacaggtcag tactgtaccg aggatgtgga cgagtgccag      900

ctgatgccaa atgcctgcca gaacggcggg acctgccaca acacccacgg tggctacaac      960

tgcgtgtgtg tcaacggctg gactggtgag gactgcagcg agaacattga tgactgtgcc     1020

agcgccgcct gcttccacgg cgccacctgc catgaccgtg tggcctcctt ctactgcgag     1080

tgtccccatg gccgcacagg tctgctgtgc cacctcaacg acgcatgcat cagcaacccc     1140

tgtaacgagg gctccaactg cgacaccaac cctgtcaatg gcaaggccat ctgcacctgc     1200

ccctcggggt acacgggccc ggcctgcagc caggacgtgg atgagtgctc gctgggtgcc     1260

aacccctgcg agcatgcggg caagtgcatc aacacgctgg gctccttcga gtgccagtgt     1320

ctgcagggct acacgggccc ccgatgcgag atcgacgtca acgagtgcgt ctcgaacccg     1380

tgccagaacg acgccacctg cctggaccag attggggagt tccagtgcat ctgcatgccc     1440

ggctacgagg gtgtgcactg cgaggtcaac acagacgagt gtgccagcag cccctgcctg     1500

cacaatggcc gctgcctgga caagatcaat gagttccagt gcgagtgccc cacgggcttc     1560

actgggcatc tgtgccagta cgatgtggac gagtgtgcca gcaccccctg caagaatggt     1620

gccaagtgcc tggacggacc caacacttac acctgtgtgt gcacggaagg gtacacgggg     1680

acgcactgcg aggtggacat cgatgagtgc gaccccgacc cctgccacta cggctcctgc     1740

aaggacggcg tcgccacctt cacctgcctc tgccgcccag gctacacggg ccaccactgc     1800

gagaccaaca tcaacgagtg ctccagccag ccctgccgcc acgggggcac ctgccaggac     1860

cgcgacaacg cctacctctg cttctgcctg aaggggacca caggacccaa ctgcgagatc     1920

aacctggatg actgtgccag cagcccctgc gactcgggca cctgtctgga caagatcgat     1980

ggctacgagt gtgcctgtga gccgggctac acagggagca tgtgtaacat caacatcgat     2040

gagtgtgcgg gcaacccctg ccacaacggg ggcacctgcg aggacggcat caatggcttc     2100

acctgccgct gccccgaggg ctaccacgac cccacctgcc tgtctgaggt caatgagtgc     2160

aacagcaacc cctgcgtcca cggggcctgc cgggacagcc tcaacgggta caagtgcgac     2220

tgtgaccctg ggtggagtgg gaccaactgt gacatcaaca acaatgagtg tgaatccaac     2280

ccttgtgtca acggcggcac ctgcaaagac atgaccagtg gctacgtgtg cacctgccgg     2340

gagggcttca gcggtcccaa ctgccagacc aacatcaacg agtgtgcgtc caacccatgt     2400

ctgaaccagg gcacgtgtat tgacgacgtt gccgggtaca agtgcaactg cctgctgccc     2460

tacacaggtg ccacgtgtga ggtggtgctg gccccgtgtg cccccagccc ctgcagaaac     2520

ggcggggagt gcaggcaatc cgaggactat gagagcttct cctgtgtctg ccccacgggc     2580

tggcaagggc agacctgtga ggtcgacatc aacgagtgcg ttctgagccc gtgccggcac     2640

ggcgcatcct gccagaacac ccacggcggc taccgctgcc actgccaggc cggctacagt     2700

gggcgcaact gcgagaccga catcgacgac tgccggccca acccgtgtca caacgggggc     2760

tcctgcacag acggcatcaa cacggccttc tgcgactgcc tgcccggctt ccggggcact     2820

ttctgtgagg aggacatcaa cgagtgtgcc agtgacccct gccgcaacgg ggccaactgc     2880

acggactgcg tggacagcta cacgtgcacc tgccccgcag gcttcagcgg gatccactgt     2940

gagaacaaca cgcctgactg cacagagagc tcctgcttca acggtggcac ctgcgtggac     3000

ggcatcaact cgttcacctg cctgtgtcca cccggcttca cgggcagcta ctgccagcac     3060

gatgtcaatg agtgcgactc acagccctgc ctgcatggcg gcacctgtca ggacggctgc     3120

ggctcctaca ggtgcacctg cccccagggc tacactggcc ccaactgcca gaaccttgtg     3180

cactggtgtg actcctcgcc ctgcaagaac ggcggcaaat gctggcagac ccacacccag     3240

taccgctgcg agtgccccag cggctggacc ggcctttact gcgacgtgcc cagcgtgtcc     3300

tgtgaggtgg ctgcgcagcg acaaggtgtt gacgttgccc gcctgtgcca gcatggaggg     3360

ctctgtgtgg acgcgggcaa cacgcaccac tgccgctgcc aggcgggcta cacaggcagc     3420

tactgtgagg acctggtgga cgagtgctca cccagcccct gccagaacgg ggccacctgc     3480

acggactacc tgggcggcta ctcctgcaag tgcgtggccg gctaccacgg ggtgaactgc     3540

tctgaggaga tcgacgagtg cctctcccac ccctgccaga acgggggcac ctgcctcgac     3600

ctccccaaca cctacaagtg ctcctgccca cggggcactc agggtgtgca ctgtgagatc     3660

aacgtggacg actgcaatcc ccccgttgac cccgtgtccc ggagccccaa gtgctttaac     3720

aacggcacct gcgtggacca ggtgggcggc tacagctgca cctgcccgcc gggcttcgtg     3780

ggtgagcgct gtgaggggga tgtcaacgag tgcctgtcca atccctgcga cgcccgtggc     3840

acccagaact gcgtgcagcg cgtcaatgac ttccactgcg agtgccgtgc tggtcacacc     3900

gggcgccgct gcgagtccgt catcaatggc tgcaaaggca agccctgcaa gaatgggggc     3960

acctgcgccg tggcctccaa caccgcccgc gggttcatct gcaagtgccc tgcgggcttc     4020

gagggcgcca cgtgtgagaa tgacgctcgt acctgcggca gcctgcgctg cctcaacggc     4080

ggcacatgca tctccggccc gcgcagcccc acctgcctgt gcctgggccc cttcacgggc     4140

cccgaatgcc agttcccggc cagcagcccc tgcctgggcg gcaacccctg ctacaaccag     4200

gggacctgtg agcccacatc cgagagcccc ttctaccgtt gcctgtgccc cgccaaattc     4260

aacgggctct tgtgccacat cctggactac agcttcgggg gtggggccgg gcgcgacatc     4320

cccccgccgc tgatcgagga ggcgtgcgag ctgcccgagt gccaggagga cgcgggcaac     4380

aaggtctgca gcctgcagtg caacaaccac gcgtgcggct gggacggcgg tgactgctcc     4440

ctcaacttca atgacccctg gaagaactgc acgcagtctc tgcagtgctg gaagtacttc     4500

agtgacggcc actgtgacag ccagtgcaac tcagccggct gcctcttcga cggctttgac     4560

tgccagcgtg cggaaggcca gtgcaacccc ctgtacgacc agtactgcaa ggaccacttc     4620

agcgacgggc actgcgacca gggctgcaac agcgcggagt gcgagtggga cgggctggac     4680

tgtgcggagc atgtacccga gaggctggcg gccggcacgc tggtggtggt ggtgctgatg     4740

ccgccggagc agctgcgcaa cagctccttc cacttcctgc gggagctcag ccgcgtgctg     4800

cacaccaacg tggtcttcaa gcgtgacgca cacggccagc agatgatctt cccctactac     4860

ggccgcgagg aggagctgcg caagcacccc atcaagcgtg ccgccgaggg ctgggccgca     4920

cctgacgccc tgctgggcca ggtgaaggcc tcgctgctcc ctggtggcag cgagggtggg     4980

cggcggcgga gggagctgga ccccatggac gtccgcggct ccatcgtcta cctggagatt     5040

gacaaccggc agtgtgtgca ggcctcctcg cagtgcttcc agagtgccac cgacgtggcc     5100

gcattcctgg gagcgctcgc ctcgctgggc agcctcaaca tcccctacaa gatcgaggcc     5160

gtgcagagtg agaccgtgga gccgcccccg ccggcgcagc tgcacttcat gtacgtggcg     5220

gcggccgcct ttgtgcttct gttcttcgtg ggctgcgggg tgctgctgtc ccgcaagcgc     5280

cggcggcagc atggccagct ctggttccct gagggcttca aagtgtctga ggccagcaag     5340

aagaagcggc gggagcccct cggcgaggac tccgtgggcc tcaagcccct gaagaacgct     5400

tcagacggtg ccctcatgga cgacaaccag aatgagtggg gggacgagga cctggagacc     5460

aagaagttcc ggttcgagga gcccgtggtt ctgcctgacc tggacgacca gacagaccac     5520

cggcagtgga ctcagcagca cctggatgcc gctgacctgc gcatgtctgc catggccccc     5580

acaccgcccc agggtgaggt tgacgccgac tgcatggacg tcaatgtccg cgggcctgat     5640

ggcttcaccc cgctcatgat cgcctcctgc agcgggggcg gcctggagac gggcaacagc     5700

gaggaagagg aggacgcgcc ggccgtcatc tccgacttca tctaccaggg cgccagcctg     5760

cacaaccaga cagaccgcac gggcgagacc gccttgcacc tggccgcccg ctactcacgc     5820

tctgatgccg ccaagcgcct gctggaggcc agcgcagatg ccaacatcca ggacaacatg     5880

ggccgcaccc cgctgcatgc ggctgtgtct gccgacgcac aaggtgtctt ccagatcctg     5940

atccggaacc gagccacaga cctggatgcc cgcatgcatg atggcacgac gccactgatc     6000

ctggctgccc gcctggccgt ggagggcatg ctggaggacc tcatcaactc acacgccgac     6060

gtcaacgccg tagatgacct gggcaagtcc gccctgcact gggccgccgc cgtgaacaat     6120

gtggatgccg cagttgtgct cctgaagaac ggggctaaca aagatatgca gaacaacagg     6180

gaggagacac ccctgtttct ggccgcccgg gagggcagct acgagaccgc caaggtgctg     6240

ctggaccact ttgccaaccg ggacatcacg gatcatatgg accgcctgcc gcgcgacatc     6300

gcacaggagc gcatgcatca cgacatcgtg aggctgctgg acgagtacaa cctggtgcgc     6360

agcccgcagc tgcacggagc cccgctgggg ggcacgccca ccctgtcgcc cccgctctgc     6420

tcgcccaacg gctacctggg cagcctcaag cccggcgtgc agggcaagaa ggtccgcaag     6480

cccagcagca aaggcctggc ctgtggaagc aaggaggcca aggacctcaa ggcacggagg     6540

aagaagtccc aggacggcaa gggctgcctg ctggacagct ccggcatgct ctcgcccgtg     6600

gactccctgg agtcacccca tggctacctg tcagacgtgg cctcgccgcc actgctgccc     6660

tccccgttcc agcagtctcc gtccgtgccc ctcaaccacc tgcctgggat gcccgacacc     6720

cacctgggca tcgggcacct gaacgtggcg gccaagcccg agatggcggc gctgggtggg     6780

ggcggccggc tggcctttga gactggccca cctcgtctct cccacctgcc tgtggcctct     6840

ggcaccagca ccgtcctggg ctccagcagc ggaggggccc tgaatttcac tgtgggcggg     6900

tccaccagtt tgaatggtca atgcgagtgg ctgtcccggc tgcagagcgg catggtgccg     6960

aaccaataca accctctgcg ggggagtgtg gcaccaggcc ccctgagcac acaggccccc     7020

tccctgcagc atggcatggt aggcccgctg cacagtagcc ttgctgccag cgccctgtcc     7080

cagatgatga gctaccaggg cctgcccagc acccggctgg ccacccagcc tcacctggtg     7140

cagacccagc aggtgcagcc acaaaactta cagatgcagc agcagaacct gcagccagca     7200

aacatccagc agcagcaaag cctgcagccg ccaccaccac caccacagcc gcaccttggc     7260

gtgagctcag cagccagcgg ccacctgggc cggagcttcc tgagtggaga gccgagccag     7320

gcagacgtgc agccactggg ccccagcagc ctggcggtgc acactattct gccccaggag     7380

agccccgccc tgcccacgtc gctgccatcc tcgctggtcc cacccgtgac cgcagcccag     7440

ttcctgacgc ccccctcgca gcacagctac tcctcgcctg tggacaacac ccccagccac     7500

cagctacagg tgcctgagca ccccttcctc accccgtccc ctgagtcccc tgaccagtgg     7560

tccagctcgt ccccgcattc caacgtctcc gactggtccg agggcgtctc cagccctccc     7620

accagcatgc agtcccagat cgcccgcatt ccggaggcct tcaagtaaac ggcgcgcccc     7680

acgagacccc ggcttccttt cccaagcctt cgggcgtctg tgtgcgctct gtggatgcca     7740

gggccgacca gaggagcctt tttaaaacac atgtttttat acaaaataag aacgaggatt     7800

ttaatttttt ttagtattta tttatgtact tttattttac acagaaacac tgccttttta     7860

tttatatgta ctgttttatc tggccccagg tagaaacttt tatctattct gagaaaacaa     7920

gcaagttctg agagccaggg ttttcctacg taggatgaaa agattcttct gtgtttataa     7980

aatataaaca aagattcatg atttataaat gccatttatt tattgattcc ttttttcaaa     8040

atccaaaaag aaatgatgtt ggagaaggga agttgaacga gcatagtcca aaaagctcct     8100

ggggcgtcca ggccgcgccc tttccccgac gcccacccaa ccccaagcca gcccggccgc     8160

tccaccagca tcacctgcct gttaggagaa gctgcatcca gaggcaaacg gaggcaaagc     8220

tggctcacct tccgcacgcg gattaatttg catctgaaat aggaaacaag tgaaagcata     8280

tgggttagat gttgccatgt gttttagatg gtttcttgca agcatgcttg tgaaaatgtg     8340

ttctcggagt gtgtatgcca agagtgcacc catggtacca atcatgaatc tttgtttcag     8400

gttcagtatt atgtagttgt tcgttggtta tacaagttct tggtccctcc agaaccaccc     8460

cggccccctg cccgttcttg aaatgtaggc atcatgcatg tcaaacatga gatgtgtgga     8520

ctgtggcact tgcctgggtc acacacggag gcatcctacc cttttctggg gaaagacact     8580

gcctgggctg accccggtgg cggccccagc acctcagcct gcacagtgtc ccccaggttc     8640

cgaagaagat gctccagcaa cacagcctgg gccccagctc gcgggacccg accccccgtg     8700

ggctcccgtg ttttgtagga gacttgccag agccgggcac attgagctgt gcaacgccgt     8760

gggctgcgtc ctttggtcct gtccccgcag ccctggcagg gggcatgcgg tcgggcaggg     8820

gctggaggga ggcgggggct gcccttgggc cacccctcct agtttgggag gagcagattt     8880

ttgcaatacc aagtatagcc tatggcagaa aaaatgtctg taaatatgtt tttaaaggtg     8940

gattttgttt aaaaaatctt aatgaatgag tctgttgtgt gtcatgccag tgagggacgt     9000

cagacttggc tcagctcggg gagccttagc cgcccatgca ctggggacgc tccgctgccg     9060

tgccgcctgc actcctcagg gcagcctccc ccggctctac gggggccgcg tggtgccatc     9120

cccagggggc atgaccagat gcgtcccaag atgttgattt ttactgtgtt ttataaaata     9180

gagtgtagtt tacagaaaaa gactttaaaa gtgatctaca tgaggaactg tagatgatgt     9240

atttttttca tcttttttgt taactgattt gcaataaaaa tgatactgat ggtgatctgg     9300

cttccaaaaa aaaaaaaaaa aa                                              9322


<210> 9
<211> 2471
<212> PRT
<213> Homo sapiens

<400> 9
Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Thr Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Leu Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp His Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210> 10
<211> 11189
<212> DNA
<213> Homo sapiens

<400> 10
gcgaccgaga agatgcccgc cctgcgcccc gctctgctgt gggcgctgct ggcgctctgg       60

ctgtgctgcg cgacccccgc gcatgcattg cagtgtcgag atggctatga accctgtgta      120

aatgaaggaa tgtgtgttac ctaccacaat ggcacaggat actgcaaatg tccagaaggc      180

ttcttggggg aatattgtca acatcgagac ccctgtgaga agaaccgctg ccagaatggt      240

gggacttgtg tggcccaggc catgctgggg aaagccacgt gccgatgtgc ctcagggttt      300

acaggagagg actgccagta ctcgacatct catccatgct ttgtgtctcg accctgcctg      360

aatggcggca catgccatat gctcagccgg gatacctatg agtgcacctg tcaagtcggg      420

tttacaggta aggagtgcca atggaccgat gcctgcctgt ctcatccctg tgcaaatgga      480

agtacctgta ccactgtggc caaccagttc tcctgcaaat gcctcacagg cttcacaggg      540

cagaaatgtg agactgatgt caatgagtgt gacattccag gacactgcca gcatggtggc      600

acctgcctca acctgcctgg ttcctaccag tgccagtgcc ttcagggctt cacaggccag      660

tactgtgaca gcctgtatgt gccctgtgca ccctcgcctt gtgtcaatgg aggcacctgt      720

cggcagactg gtgacttcac ttttgagtgc aactgccttc caggttttga agggagcacc      780

tgtgagagga atattgatga ctgccctaac cacaggtgtc agaatggagg ggtttgtgtg      840

gatggggtca acacttacaa ctgccgctgt cccccacaat ggacaggaca gttctgcaca      900

gaggatgtgg atgaatgcct gctgcagccc aatgcctgtc aaaatggggg cacctgtgcc      960

aaccgcaatg gaggctatgg ctgtgtatgt gtcaacggct ggagtggaga tgactgcagt     1020

gagaacattg atgattgtgc cttcgcctcc tgtactccag gctccacctg catcgaccgt     1080

gtggcctcct tctcttgcat gtgcccagag gggaaggcag gtctcctgtg tcatctggat     1140

gatgcatgca tcagcaatcc ttgccacaag ggggcactgt gtgacaccaa ccccctaaat     1200

gggcaatata tttgcacctg cccacaaggc tacaaagggg ctgactgcac agaagatgtg     1260

gatgaatgtg ccatggccaa tagcaatcct tgtgagcatg caggaaaatg tgtgaacacg     1320

gatggcgcct tccactgtga gtgtctgaag ggttatgcag gacctcgttg tgagatggac     1380

atcaatgagt gccattcaga cccctgccag aatgatgcta cctgtctgga taagattgga     1440

ggcttcacat gtctgtgcat gccaggtttc aaaggtgtgc attgtgaatt agaaataaat     1500

gaatgtcaga gcaacccttg tgtgaacaat gggcagtgtg tggataaagt caatcgtttc     1560

cagtgcctgt gtcctcctgg tttcactggg ccagtttgcc agattgatat tgatgactgt     1620

tccagtactc cgtgtctgaa tggggcaaag tgtatcgatc acccgaatgg ctatgaatgc     1680

cagtgtgcca caggtttcac tggtgtgttg tgtgaggaga acattgacaa ctgtgacccc     1740

gatccttgcc accatggtca gtgtcaggat ggtattgatt cctacacctg catctgcaat     1800

cccgggtaca tgggcgccat ctgcagtgac cagattgatg aatgttacag cagcccttgc     1860

ctgaacgatg gtcgctgcat tgacctggtc aatggctacc agtgcaactg ccagccaggc     1920

acgtcagggg ttaattgtga aattaatttt gatgactgtg caagtaaccc ttgtatccat     1980

ggaatctgta tggatggcat taatcgctac agttgtgtct gctcaccagg attcacaggg     2040

cagagatgta acattgacat tgatgagtgt gcctccaatc cctgtcgcaa gggtgcaaca     2100

tgtatcaacg gtgtgaatgg tttccgctgt atatgccccg agggacccca tcaccccagc     2160

tgctactcac aggtgaacga atgcctgagc aatccctgca tccatggaaa ctgtactgga     2220

ggtctcagtg gatataagtg tctctgtgat gcaggctggg ttggcatcaa ctgtgaagtg     2280

gacaaaaatg aatgcctttc gaatccatgc cagaatggag gaacttgtga caatctggtg     2340

aatggataca ggtgtacttg caagaagggc tttaaaggct ataactgcca ggtgaatatt     2400

gatgaatgtg cctcaaatcc atgcctgaac caaggaacct gctttgatga cataagtggc     2460

tacacttgcc actgtgtgct gccatacaca ggcaagaatt gtcagacagt attggctccc     2520

tgttccccaa acccttgtga gaatgctgct gtttgcaaag agtcaccaaa ttttgagagt     2580

tatacttgct tgtgtgctcc tggctggcaa ggtcagcggt gtaccattga cattgacgag     2640

tgtatctcca agccctgcat gaaccatggt ctctgccata acacccaggg cagctacatg     2700

tgtgaatgtc caccaggctt cagtggtatg gactgtgagg aggacattga tgactgcctt     2760

gccaatcctt gccagaatgg aggttcctgt atggatggag tgaatacttt ctcctgcctc     2820

tgccttccgg gtttcactgg ggataagtgc cagacagaca tgaatgagtg tctgagtgaa     2880

ccctgtaaga atggagggac ctgctctgac tacgtcaaca gttacacttg caagtgccag     2940

gcaggatttg atggagtcca ttgtgagaac aacatcaatg agtgcactga gagctcctgt     3000

ttcaatggtg gcacatgtgt tgatgggatt aactccttct cttgcttgtg ccctgtgggt     3060

ttcactggat ccttctgcct ccatgagatc aatgaatgca gctctcatcc atgcctgaat     3120

gagggaacgt gtgttgatgg cctgggtacc taccgctgca gctgccccct gggctacact     3180

gggaaaaact gtcagaccct ggtgaatctc tgcagtcggt ctccatgtaa aaacaaaggt     3240

acttgcgttc agaaaaaagc agagtcccag tgcctatgtc catctggatg ggctggtgcc     3300

tattgtgacg tgcccaatgt ctcttgtgac atagcagcct ccaggagagg tgtgcttgtt     3360

gaacacttgt gccagcactc aggtgtctgc atcaatgctg gcaacacgca ttactgtcag     3420

tgccccctgg gctatactgg gagctactgt gaggagcaac tcgatgagtg tgcgtccaac     3480

ccctgccagc acggggcaac atgcagtgac ttcattggtg gatacagatg cgagtgtgtc     3540

ccaggctatc agggtgtcaa ctgtgagtat gaagtggatg agtgccagaa tcagccctgc     3600

cagaatggag gcacctgtat tgaccttgtg aaccatttca agtgctcttg cccaccaggc     3660

actcggggcc tactctgtga agagaacatt gatgactgtg cccggggtcc ccattgcctt     3720

aatggtggtc agtgcatgga taggattgga ggctacagtt gtcgctgctt gcctggcttt     3780

gctggggagc gttgtgaggg agacatcaac gagtgcctct ccaacccctg cagctctgag     3840

ggcagcctgg actgtataca gctcaccaat gactacctgt gtgtttgccg tagtgccttt     3900

actggccggc actgtgaaac cttcgtcgat gtgtgtcccc agatgccctg cctgaatgga     3960

gggacttgtg ctgtggccag taacatgcct gatggtttca tttgccgttg tcccccggga     4020

ttttccgggg caaggtgcca gagcagctgt ggacaagtga aatgtaggaa gggggagcag     4080

tgtgtgcaca ccgcctctgg accccgctgc ttctgcccca gtccccggga ctgcgagtca     4140

ggctgtgcca gtagcccctg ccagcacggg ggcagctgcc accctcagcg ccagcctcct     4200

tattactcct gccagtgtgc cccaccattc tcgggtagcc gctgtgaact ctacacggca     4260

ccccccagca cccctcctgc cacctgtctg agccagtatt gtgccgacaa agctcgggat     4320

ggcgtctgtg atgaggcctg caacagccat gcctgccagt gggatggggg tgactgttct     4380

ctcaccatgg agaacccctg ggccaactgc tcctccccac ttccctgctg ggattatatc     4440

aacaaccagt gtgatgagct gtgcaacacg gtcgagtgcc tgtttgacaa ctttgaatgc     4500

caggggaaca gcaagacatg caagtatgac aaatactgtg cagaccactt caaagacaac     4560

cactgtgacc aggggtgcaa cagtgaggag tgtggttggg atgggctgga ctgtgctgct     4620

gaccaacctg agaacctggc agaaggtacc ctggttattg tggtattgat gccacctgaa     4680

caactgctcc aggatgctcg cagcttcttg cgggcactgg gtaccctgct ccacaccaac     4740

ctgcgcatta agcgggactc ccagggggaa ctcatggtgt acccctatta tggtgagaag     4800

tcagctgcta tgaagaaaca gaggatgaca cgcagatccc ttcctggtga acaagaacag     4860

gaggtggctg gctctaaagt ctttctggaa attgacaacc gccagtgtgt tcaagactca     4920

gaccactgct tcaagaacac ggatgcagca gcagctctcc tggcctctca cgccatacag     4980

gggaccctgt cataccctct tgtgtctgtc gtcagtgaat ccctgactcc agaacgcact     5040

cagctcctct atctccttgc tgttgctgtt gtcatcattc tgtttattat tctgctgggg     5100

gtaatcatgg caaaacgaaa gcgtaagcat ggctctctct ggctgcctga aggtttcact     5160

cttcgccgag atgcaagcaa tcacaagcgt cgtgagccag tgggacagga tgctgtgggg     5220

ctgaaaaatc tctcagtgca agtctcagaa gctaacctaa ttggtactgg aacaagtgaa     5280

cactgggtcg atgatgaagg gccccagcca aagaaagtaa aggctgaaga tgaggcctta     5340

ctctcagaag aagatgaccc cattgatcga cggccatgga cacagcagca ccttgaagct     5400

gcagacatcc gtaggacacc atcgctggct ctcacccctc ctcaggcaga gcaggaggtg     5460

gatgtgttag atgtgaatgt ccgtggccca gatggctgca ccccattgat gttggcttct     5520

ctccgaggag gcagctcaga tttgagtgat gaagatgaag atgcagagga ctcttctgct     5580

aacatcatca cagacttggt ctaccagggt gccagcctcc aggcccagac agaccggact     5640

ggtgagatgg ccctgcacct tgcagcccgc tactcacggg ctgatgctgc caagcgtctc     5700

ctggatgcag gtgcagatgc caatgcccag gacaacatgg gccgctgtcc actccatgct     5760

gcagtggcag ctgatgccca aggtgtcttc cagattctga ttcgcaaccg agtaactgat     5820

ctagatgcca ggatgaatga tggtactaca cccctgatcc tggctgcccg cctggctgtg     5880

gagggaatgg tggcagaact gatcaactgc caagcggatg tgaatgcagt ggatgaccat     5940

ggaaaatctg ctcttcactg ggcagctgct gtcaataatg tggaggcaac tcttttgttg     6000

ttgaaaaatg gggccaaccg agacatgcag gacaacaagg aagagacacc tctgtttctt     6060

gctgcccggg aggggagcta tgaagcagcc aagatcctgt tagaccattt tgccaatcga     6120

gacatcacag accatatgga tcgtcttccc cgggatgtgg ctcgggatca catgcaccat     6180

gacattgtgc gccttctgga tgaatacaat gtgaccccaa gccctccagg caccgtgttg     6240

acttctgctc tctcacctgt catctgtggg cccaacagat ctttcctcag cctgaagcac     6300

accccaatgg gcaagaagtc tagacggccc agtgccaaga gtaccatgcc tactagcctc     6360

cctaaccttg ccaaggaggc aaaggatgcc aagggtagta ggaggaagaa gtctctgagt     6420

gagaaggtcc aactgtctga gagttcagta actttatccc ctgttgattc cctagaatct     6480

cctcacacgt atgtttccga caccacatcc tctccaatga ttacatcccc tgggatctta     6540

caggcctcac ccaaccctat gttggccact gccgcccctc ctgccccagt ccatgcccag     6600

catgcactat ctttttctaa ccttcatgaa atgcagcctt tggcacatgg ggccagcact     6660

gtgcttccct cagtgagcca gttgctatcc caccaccaca ttgtgtctcc aggcagtggc     6720

agtgctggaa gcttgagtag gctccatcca gtcccagtcc cagcagattg gatgaaccgc     6780

atggaggtga atgagaccca gtacaatgag atgtttggta tggtcctggc tccagctgag     6840

ggcacccatc ctggcatagc tccccagagc aggccacctg aagggaagca cataaccacc     6900

cctcgggagc ccttgccccc cattgtgact ttccagctca tccctaaagg cagtattgcc     6960

caaccagcgg gggctcccca gcctcagtcc acctgccctc cagctgttgc gggccccctg     7020

cccaccatgt accagattcc agaaatggcc cgtttgccca gtgtggcttt ccccactgcc     7080

atgatgcccc agcaggacgg gcaggtagct cagaccattc tcccagccta tcatcctttc     7140

ccagcctctg tgggcaagta ccccacaccc ccttcacagc acagttatgc ttcctcaaat     7200

gctgctgagc gaacacccag tcacagtggt cacctccagg gtgagcatcc ctacctgaca     7260

ccatccccag agtctcctga ccagtggtca agttcatcac cccactctgc ttctgactgg     7320

tcagatgtga ccaccagccc tacccctggg ggtgctggag gaggtcagcg gggacctggg     7380

acacacatgt ctgagccacc acacaacaac atgcaggttt atgcgtgaga gagtccacct     7440

ccagtgtaga gacataactg acttttgtaa atgctgctga ggaacaaatg aaggtcatcc     7500

gggagagaaa tgaagaaatc tctggagcca gcttctagag gtaggaaaga gaagatgttc     7560

ttattcagat aatgcaagag aagcaattcg tcagtttcac tgggtatctg caaggcttat     7620

tgattattct aatctaataa gacaagtttg tggaaatgca agatgaatac aagccttggg     7680

tccatgttta ctctcttcta tttggagaat aagatggatg cttattgaag cccagacatt     7740

cttgcagctt ggactgcatt ttaagccctg caggcttctg ccatatccat gagaagattc     7800

tacactagcg tcctgttggg aattatgccc tggaattctg cctgaattga cctacgcatc     7860

tcctcctcct tggacattct tttgtcttca tttggtgctt ttggttttgc acctctccgt     7920

gattgtagcc ctaccagcat gttatagggc aagacctttg tgcttttgat cattctggcc     7980

catgaaagca actttggtct cctttcccct cctgtcttcc cggtatccct tggagtctca     8040

caaggtttac tttggtatgg ttctcagcac aaacctttca agtatgttgt ttctttggaa     8100

aatggacata ctgtattgtg ttctcctgca tatatcattc ctggagagag aaggggagaa     8160

gaatactttt cttcaacaaa ttttgggggc aggagatccc ttcaagaggc tgcaccttaa     8220

tttttcttgt ctgtgtgcag gtcttcatat aaactttacc aggaagaagg gtgtgagttt     8280

gttgtttttc tgtgtatggg cctggtcagt gtaaagtttt atccttgata gtctagttac     8340

tatgaccctc cccacttttt taaaaccaga aaaaggtttg gaatgttgga atgaccaaga     8400

gacaagttaa ctcgtgcaag agccagttac ccacccacag gtccccctac ttcctgccaa     8460

gcattccatt gactgcctgt atggaacaca tttgtcccag atctgagcat tctaggcctg     8520

tttcactcac tcacccagca tatgaaacta gtcttaactg ttgagccttt cctttcatat     8580

ccacagaaga cactgtctca aatgttgtac ccttgccatt taggactgaa ctttccttag     8640

cccaagggac ccagtgacag ttgtcttccg tttgtcagat gatcagtctc tactgattat     8700

cttgctgctt aaaggcctgc tcaccaatct ttctttcaca ccgtgtggtc cgtgttactg     8760

gtatacccag tatgttctca ctgaagacat ggactttata tgttcaagtg caggaattgg     8820

aaagttggac ttgttttcta tgatccaaaa cagccctata agaaggttgg aaaaggagga     8880

actatatagc agcctttgct attttctgct accatttctt ttcctctgaa gcggccatga     8940

cattcccttt ggcaactaac gtagaaactc aacagaacat tttcctttcc tagagtcacc     9000

ttttagatga taatggacaa ctatagactt gctcattgtt cagactgatt gcccctcacc     9060

tgaatccact ctctgtattc atgctcttgg caatttcttt gactttcttt taagggcaga     9120

agcattttag ttaattgtag ataaagaata gttttcttcc tcttctcctt gggccagtta     9180

ataattggtc catggctaca ctgcaacttc cgtccagtgc tgtgatgccc atgacacctg     9240

caaaataagt tctgcctggg cattttgtag atattaacag gtgaattccc gactcttttg     9300

gtttgaatga cagttctcat tccttctatg gctgcaagta tgcatcagtg cttcccactt     9360

acctgatttg tctgtcggtg gccccatatg gaaaccctgc gtgtctgttg gcataatagt     9420

ttacaaatgg ttttttcagt cctatccaaa tttattgaac caacaaaaat aattacttct     9480

gccctgagat aagcagatta agtttgttca ttctctgctt tattctctcc atgtggcaac     9540

attctgtcag cctctttcat agtgtgcaaa cattttatca ttctaaatgg tgactctctg     9600

cccttggacc catttattat tcacagatgg ggagaaccta tctgcatgga cctctgtgga     9660

ccacagcgta cctgcccctt tctgccctcc tgctccagcc ccacttctga aagtatcagc     9720

tactgatcca gccactggat attttatatc ctcccttttc cttaagcaca atgtcagacc     9780

aaattgcttg tttctttttc ttggactact ttaatttgga tcctttgggt ttggagaaag     9840

ggaatgtgaa agctgtcatt acagacaaca ggtttcagtg atgaggagga caacactgcc     9900

tttcaaactt tttactgatc tcttagattt taagaactct tgaattgtgt ggtatctaat     9960

aaaagggaag gtaagatgga taatcacttt ctcatttggg ttctgaattg gagactcagt    10020

ttttatgaga cacatctttt atgccatgta tagatcctcc cctgctattt ttggtttatt    10080

tttattgtta taaatgcttt ctttctttga ctcctcttct gcctgccttt ggggataggt    10140

ttttttgttt gtttatttgc ttcctctgtt ttgttttaag catcattttc ttatgtgagg    10200

tggggaaggg aaaggtatga gggaaagaga gtctgagaat taaaatattt tagtataagc    10260

aattggctgt gatgctcaaa tccattgcat cctcttattg aatttgccaa tttgtaattt    10320

ttgcataata aagaaccaaa ggtgtaatgt tttgttgaga ggtggtttag ggattttggc    10380

cctaaccaat acattgaatg tatgatgact atttgggagg acacatttat gtacccagag    10440

gcccccacta ataagtggta ctatggttac ttccttgtgt acatttctct taaaagtgat    10500

attatatctg tttgtatgag aaacccagta accaataaaa tgaccgcata ttcctgacta    10560

aacgtagtaa ggaaaatgca cactttgttt ttacttttcc gtttcattct aaaggtagtt    10620

aagatgaaat ttatatgaaa gcatttttat cacaaaataa aaaaggtttg ccaagctcag    10680

tggtgttgta ttttttattt tccaatactg catccatggc ctggcagtgt tacctcatga    10740

tgtcataatt tgctgagaga gcaaattttc ttttctttct gaatcccaca aagcctagca    10800

ccaaacttct ttttttcttc ctttaattag atcataaata aatgatcctg gggaaaaagc    10860

atctgtcaaa taggaaacat cacaaaactg agcactcttc tgtgcactag ccatagctgg    10920

tgacaaacag atggttgctc agggacaagg tgccttccaa tggaaatgcg aagtagttgc    10980

tatagcaaga attgggaact gggatataag tcataatatt aattatgctg ttatgtaaat    11040

gattggtttg taacattcct taagtgaaat ttgtgtagaa cttaatatac aggattataa    11100

aataatattt tgtgtataaa tttgttataa gttcacattc atacatttat ttataaagtc    11160

agtgagatat ttgaacatga aaaaaaaaa                                      11189


<210> 11
<211> 2321
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Val 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210> 12
<211> 8091
<212> DNA
<213> Homo sapiens

<400> 12
acgcggcgcg gaggctggcc cgggacgcgc ccggagccca gggaaggagg gaggagggga       60

gggtcgcggc cggccgccat ggggccgggg gcccgtggcc gccgccgccg ccgtcgcccg      120

atgtcgccgc caccgccacc gccacccgtg cgggcgctgc ccctgctgct gctgctagcg      180

gggccggggg ctgcagcccc cccttgcctg gacggaagcc cgtgtgcaaa tggaggtcgt      240

tgcacccagc tgccctcccg ggaggctgcc tgcctgtgcc cgcctggctg ggtgggtgag      300

cggtgtcagc tggaggaccc ctgtcactca ggcccctgtg ctggccgtgg tgtctgccag      360

agttcagtgg tggctggcac cgcccgattc tcatgccggt gcccccgtgg cttccgaggc      420

cctgactgct ccctgccaga tccctgcctc agcagccctt gtgcccacgg tgcccgctgc      480

tcagtggggc ccgatggacg cttcctctgc tcctgcccac ctggctacca gggccgcagc      540

tgccgaagcg acgtggatga gtgccgggtg ggtgagccct gccgccatgg tggcacctgc      600

ctcaacacac ctggctcctt ccgctgccag tgtccagctg gctacacagg gccactatgt      660

gagaaccccg cggtgccctg tgcgccctca ccatgccgta acgggggcac ctgcaggcag      720

agtggcgacc tcacttacga ctgtgcctgt cttcctgggt ttgagggtca gaattgtgaa      780

gtgaacgtgg acgactgtcc aggacaccga tgtctcaatg gggggacatg cgtggatggc      840

gtcaacacct ataactgcca gtgccctcct gagtggacag gccagttctg cacggaggac      900

gtggatgagt gtcagctgca gcccaacgcc tgccacaatg ggggtacctg cttcaacacg      960

ctgggtggcc acagctgcgt gtgtgtcaat ggctggacag gtgagagctg cagtcagaat     1020

atcgatgact gtgccacagc cgtgtgcttc catggggcca cctgccatga ccgcgtggct     1080

tctttctact gtgcctgccc catgggcaag actggcctcc tgtgtcacct ggatgacgcc     1140

tgtgtcagca acccctgcca cgaggatgct atctgtgaca caaatccggt gaacggccgg     1200

gccatttgca cctgtcctcc cggcttcacg ggtggggcat gtgaccagga tgtggacgag     1260

tgctctatcg gcgccaaccc ctgcgagcac ttgggcaggt gcgtgaacac gcagggctcc     1320

ttcctgtgcc agtgcggtcg tggctacact ggacctcgct gtgagaccga tgtcaacgag     1380

tgtctgtcgg ggccctgccg aaaccaggcc acgtgcctcg accgcatagg ccagttcacc     1440

tgtatctgta tggcaggctt cacaggaacc tattgcgagg tggacattga cgagtgtcag     1500

agtagcccct gtgtcaacgg tggggtctgc aaggaccgag tcaatggctt cagctgcacc     1560

tgcccctcgg gcttcagcgg ctccacgtgt cagctggacg tggacgaatg cgccagcacg     1620

ccctgcagga atggcgccaa atgcgtggac cagcccgatg gctacgagtg ccgctgtgcc     1680

gagggctttg agggcacgct gtgtgatcgc aacgtggacg actgctcccc tgacccatgc     1740

caccatggtc gctgcgtgga tggcatcgcc agcttctcat gtgcctgtgc tcctggctac     1800

acgggcacac gctgcgagag ccaggtggac gaatgccgca gccagccctg ccgccatggc     1860

ggcaaatgcc tagacctggt ggacaagtac ctctgccgct gcccttctgg gaccacaggt     1920

gtgaactgcg aagtgaacat tgacgactgt gccagcaacc cctgcacctt tggagtctgc     1980

cgtgatggca tcaaccgcta cgactgtgtc tgccaacctg gcttcacagg gcccctttgt     2040

aacgtggaga tcaatgagtg tgcttccagc ccatgcggcg agggaggttc ctgtgtggat     2100

ggggaaaatg gcttccgctg cctctgcccg cctggctcct tgcccccact ctgcctcccc     2160

ccgagccatc cctgtgccca tgagccctgc agtcacggca tctgctatga tgcacctggc     2220

gggttccgct gtgtgtgtga gcctggctgg agtggccccc gctgcagcca gagcctggcc     2280

cgagacgcct gtgagtccca gccgtgcagg gccggtggga catgcagcag cgatggaatg     2340

ggtttccact gcacctgccc gcctggtgtc cagggacgtc agtgtgaact cctctccccc     2400

tgcaccccga acccctgtga gcatgggggc cgctgcgagt ctgcccctgg ccagctgcct     2460

gtctgctcct gcccccaggg ctggcaaggc ccacgatgcc agcaggatgt ggacgagtgt     2520

gctggccccg caccctgtgg ccctcatggt atctgcacca acctggcagg gagtttcagc     2580

tgcacctgcc atggagggta cactggccct tcctgtgatc aggacatcaa tgactgtgac     2640

cccaacccat gcctgaacgg tggctcgtgc caagacggcg tgggctcctt ttcctgctcc     2700

tgcctccctg gtttcgccgg cccacgatgc gcccgcgatg tggatgagtg cctgagcaac     2760

ccctgcggcc cgggcacctg taccgaccac gtggcctcct tcacctgcac ctgcccgccg     2820

ggctacggag gcttccactg cgaacaggac ctgcccgact gcagccccag ctcctgcttc     2880

aatggcggga cctgtgtgga cggcgtgaac tcgttcagct gcctgtgccg tcccggctac     2940

acaggagccc actgccaaca tgaggcagac ccctgcctct cgcggccctg cctacacggg     3000

ggcgtctgca gcgccgccca ccctggcttc cgctgcacct gcctcgagag cttcacgggc     3060

ccgcagtgcc agacgctggt ggattggtgc agccgccagc cttgtcaaaa cgggggtcgc     3120

tgcgtccaga ctggggccta ttgcctttgt ccccctggat ggagcggacg cctctgtgac     3180

atccgaagct tgccctgcag ggaggccgca gcccagatcg gggtgcggct ggagcagctg     3240

tgtcaggcgg gtgggcagtg tgtggatgaa gacagctccc actactgcgt gtgcccagag     3300

ggccgtactg gtagccactg tgagcaggag gtggacccct gcttggccca gccctgccag     3360

catgggggga cctgccgtgg ctatatgggg ggctacatgt gtgagtgtct tcctggctac     3420

aatggtgata actgtgagga cgacgtggac gagtgtgcct cccagccctg ccagcacggg     3480

ggttcatgca ttgacctcgt ggcccgctat ctctgctcct gtcccccagg aacgctgggg     3540

gtgctctgcg agattaatga ggatgactgc ggcccaggcc caccgctgga ctcagggccc     3600

cggtgcctac acaatggcac ctgcgtggac ctggtgggtg gtttccgctg cacctgtccc     3660

ccaggataca ctggtttgcg ctgcgaggca gacatcaatg agtgtcgctc aggtgcctgc     3720

cacgcggcac acacccggga ctgcctgcag gacccaggcg gaggtttccg ttgcctttgt     3780

catgctggct tctcaggtcc tcgctgtcag actgtcctgt ctccctgcga gtcccagcca     3840

tgccagcatg gaggccagtg ccgtcctagc ccgggtcctg ggggtgggct gaccttcacc     3900

tgtcactgtg cccagccgtt ctggggtccg cgttgcgagc gggtggcgcg ctcctgccgg     3960

gagctgcagt gcccggtggg cgtcccatgc cagcagacgc cccgcgggcc gcgctgcgcc     4020

tgccccccag ggttgtcggg accctcctgc cgcagcttcc cggggtcgcc gccgggggcc     4080

agcaacgcca gctgcgcggc cgccccctgt ctccacgggg gctcctgccg ccccgcgccg     4140

ctcgcgccct tcttccgctg cgcttgcgcg cagggctgga ccgggccgcg ctgcgaggcg     4200

cccgccgcgg cacccgaggt ctcggaggag ccgcggtgcc cgcgcgccgc ctgccaggcc     4260

aagcgcgggg accagcgctg cgaccgcgag tgcaacagcc caggctgcgg ctgggacggc     4320

ggcgactgct cgctgagcgt gggcgacccc tggcggcaat gcgaggcgct gcagtgctgg     4380

cgcctcttca acaacagccg ctgcgacccc gcctgcagct cgcccgcctg cctctacgac     4440

aacttcgact gccacgccgg tggccgcgag cgcacttgca acccggtgta cgagaagtac     4500

tgcgccgacc actttgccga cggccgctgc gaccagggct gcaacacgga ggagtgcggc     4560

tgggatgggc tggattgtgc cagcgaggtg ccggccctgc tggcccgcgg cgtgctggtg     4620

ctcacagtgc tgctgccgcc ggaggagcta ctgcgttcca gcgccgactt tctgcagcgg     4680

ctcagcgcca tcctgcgcac ctcgctgcgc ttccgcctgg acgcgcacgg ccaggccatg     4740

gtcttccctt accaccggcc tagtcctggc tccgaacccc gggcccgtcg ggagctggcc     4800

cccgaggtga tcggctcggt agtaatgctg gagattgaca accggctctg cctgcagtcg     4860

cctgagaatg atcactgctt ccccgatgcc cagagcgccg ctgactacct gggagcgttg     4920

tcagcggtgg agcgcctgga cttcccgtac ccactgcggg acgtgcgggg ggagccgctg     4980

gagcctccag aacccagcgt cccgctgctg ccactgctag tggcgggcgc tgtcttgctg     5040

ctggtcattc tcgtcctggg tgtcatggtg gcccggcgca agcgcgagca cagcaccctc     5100

tggttccctg agggcttctc actgcacaag gacgtggcct ctggtcacaa gggccggcgg     5160

gaacccgtgg gccaggacgc gctgggcatg aagaacatgg ccaagggtga gagcctgatg     5220

ggggaggtgg ccacagactg gatggacaca gagtgcccag aggccaagcg gctaaaggta     5280

gaggagccag gcatgggggc tgaggaggct gtggattgcc gtcagtggac tcaacaccat     5340

ctggttgctg ctgacatccg cgtggcacca gccatggcac tgacaccacc acagggcgac     5400

gcagatgctg atggcatgga tgtcaatgtg cgtggcccag atggcttcac cccgctaatg     5460

ctggcttcct tctgtggggg ggctctggag ccaatgccaa ctgaagagga tgaggcagat     5520

gacacatcag ctagcatcat ctccgacctg atctgccagg gggctcagct tggggcacgg     5580

actgaccgta ctggcgagac tgctttgcac ctggctgccc gttatgcccg tgctgatgca     5640

gccaagcggc tgctggatgc tggggcagac accaatgccc aggaccactc aggccgcact     5700

cccctgcaca cagctgtcac agccgatgcc cagggtgtct tccagattct catccgaaac     5760

cgctctacag acttggatgc ccgcatggca gatggctcaa cggcactgat cctggcggcc     5820

cgcctggcag tagagggcat ggtggaagag ctcatcgcca gccatgctga tgtcaatgct     5880

gtggatgagc ttgggaaatc agccttacac tgggctgcgg ctgtgaacaa cgtggaagcc     5940

actttggccc tgctcaaaaa tggagccaat aaggacatgc aggatagcaa ggaggagacc     6000

cccctattcc tggccgcccg cgagggcagc tatgaggctg ccaagctgct gttggaccac     6060

tttgccaacc gtgagatcac cgaccacctg gacaggctgc cgcgggacgt agcccaggag     6120

agactgcacc aggacatcgt gcgcttgctg gatcaaccca gtgggccccg cagccccccc     6180

ggtccccacg gcctggggcc tctgctctgt cctccagggg ccttcctccc tggcctcaaa     6240

gcggcacagt cggggtccaa gaagagcagg aggccccccg ggaaggcggg gctggggccg     6300

caggggcccc gggggcgggg caagaagctg acgctggcct gcccgggccc cctggctgac     6360

agctcggtca cgctgtcgcc cgtggactcg ctggactccc cgcggccttt cggtgggccc     6420

cctgcttccc ctggtggctt cccccttgag gggccctatg cagctgccac tgccactgca     6480

gtgtctctgg cacagcttgg tggcccaggc cgggcaggtc tagggcgcca gccccctgga     6540

ggatgtgtac tcagcctggg cctgctgaac cctgtggctg tgcccctcga ttgggcccgg     6600

ctgcccccac ctgcccctcc aggcccctcg ttcctgctgc cactggcgcc gggaccccag     6660

ctgctcaacc cagggacccc cgtctccccg caggagcggc ccccgcctta cctggcagtc     6720

ccaggacatg gcgaggagta cccggtggct ggggcacaca gcagcccccc aaaggcccgc     6780

ttcctgcggg ttcccagtga gcacccttac ctgaccccat cccccgaatc ccctgagcac     6840

tgggccagcc cctcacctcc ctccctctca gactggtccg aatccacgcc tagcccagcc     6900

actgccactg gggccatggc caccaccact ggggcactgc ctgcccagcc acttcccttg     6960

tctgttccca gctcccttgc tcaggcccag acccagctgg ggccccagcc ggaagttacc     7020

cccaagaggc aagtgttggc ctgagacgct cgtcagttct tagatcttgg gggcctaaag     7080

agacccccgt cctgcctcct ttctttctct gtctcttcct tccttttagt ctttttcatc     7140

ctcttctctt tccaccaacc ctcctgcatc cttgccttgc agcgtgaccg agataggtca     7200

tcagcccagg gcttcagtct tcctttattt ataatgggtg ggggctacca cccaccctct     7260

cagtcttgtg aagagtctgg gacctccttc ttccccactt ctctcttccc tcattccttt     7320

ctctctcctt ctggcctctc atttccttac actctgacat gaatgaatta ttattatttt     7380

tctttttctt ttttttttta cattttgtat agaaacaaat tcatttaaac aaacttatta     7440

ttattatttt ttacaaaata tatatatgga gatgctccct ccccctgtga accccccagt     7500

gcccccgtgg ggctgagtct gtgggcccat tcggccaagc tggattctgt gtacctagta     7560

cacaggcatg actgggatcc cgtgtaccga gtacacgacc caggtatgta ccaagtaggc     7620

acccttgggc gcacccactg gggccagggg tcgggggagt gttgggagcc tcctccccac     7680

cccacctccc tcacttcact gcattccaga ttggacatgt tccatagcct tgctggggaa     7740

gggcccactg ccaactccct ctgccccagc cccacccttg gccatctccc tttgggaact     7800

agggggctgc tggtgggaaa tgggagccag ggcagatgta tgcattcctt tatgtccctg     7860

taaatgtggg actacaagaa gaggagctgc ctgagtggta ctttctcttc ctggtaatcc     7920

tctggcccag ccttatggca gaatagaggt atttttaggc tatttttgta atatggcttc     7980

tggtcaaaat ccctgtgtag ctgaattccc aagccctgca ttgtacagcc ccccactccc     8040

ctcaccacct aataaaggaa tagttaacac tcaaaaaaaa aaaaaaaaaa a              8091


<210> 13
<211> 2003
<212> PRT
<213> Homo sapiens

<400> 13
Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210> 14
<211> 6122
<212> DNA
<213> Homo sapiens

<400> 14
gccggccgcg tcgaccctgc cccagtgaga gctctgaggg tccctgcctg aagagggaca       60

gggaccgggg cttggagaag gggctgtgga atgcagcccc cttcactgct gctgctgctg      120

ctgctgctgc tgctgctatg tgtctcagtg gtcagaccca gagggctgct gtgtgggagt      180

ttcccagaac cctgtgccaa tggaggcacc tgcctgagcc tgtctctggg acaagggacc      240

tgccagtgtg cccctggctt cctgggtgag acgtgccagt ttcctgaccc ctgccagaac      300

gcccagctct gccaaaatgg aggcagctgc caagccctgc ttcccgctcc cctagggctc      360

cccagctctc cctctccatt gacacccagc ttcttgtgca cttgcctccc tggcttcact      420

ggtgagagat gccaggccaa gcttgaagac ccttgtcctc cctccttctg ttccaaaagg      480

ggccgctgcc acatccaggc ctcgggccgc ccacagtgct cctgcatgcc tggatggaca      540

ggtgagcagt gccagcttcg ggacttctgt tcagccaacc catgtgttaa tggaggggtg      600

tgtctggcca cataccccca gatccagtgc cactgcccac cgggcttcga gggccatgcc      660

tgtgaacgtg atgtcaacga gtgcttccag gacccaggac cctgccccaa aggcacctcc      720

tgccataaca ccctgggctc cttccagtgc ctctgccctg tggggcagga gggtccacgt      780

tgtgagctgc gggcaggacc ctgccctcct aggggctgtt cgaatggggg cacctgccag      840

ctgatgccag agaaagactc cacctttcac ctctgcctct gtcccccagg tttcataggc      900

ccagactgtg aggtgaatcc agacaactgt gtcagccacc agtgtcagaa tgggggcact      960

tgccaggatg ggctggacac ctacacctgc ctctgcccag aaacctggac aggctgggac     1020

tgctccgaag atgtggatga gtgtgagacc cagggtcccc ctcactgcag aaacgggggc     1080

acctgccaga actctgctgg tagctttcac tgcgtgtgtg tgagtggctg gggcggcaca     1140

agctgtgagg agaacctgga tgactgtatt gctgccacct gtgccccggg atccacctgc     1200

attgaccggg tgggctcttt ctcctgcctc tgcccacctg gacgcacagg actcctgtgc     1260

cacttggaag acatgtgtct gagccagccg tgccatgggg atgcccaatg cagcaccaac     1320

cccctcacag gctccacact ctgcctgtgt cagcctggct attcggggcc cacctgccac     1380

caggacctgg acgagtgtct gatggcccag caaggcccaa gtccctgtga acatggcggt     1440

tcctgcctca acactcctgg ctccttcaac tgcctctgtc cacctggcta cacaggctcc     1500

cgttgtgagg ctgatcacaa tgagtgcctc tcccagccct gccacccagg aagcacctgt     1560

ctggacctac ttgccacctt ccactgcctc tgcccgccag gcttagaagg gcagctctgt     1620

gaggtggaga ccaacgagtg tgcctcagct ccctgcctga accacgcgga ttgccatgac     1680

ctgctcaacg gcttccagtg catctgcctg cctggattct ccggcacccg atgtgaggag     1740

gatatcgatg agtgcagaag ctctccctgt gccaatggtg ggcagtgcca ggaccagcct     1800

ggagccttcc actgcaagtg tctcccaggc tttgaagggc cacgctgtca aacagaggtg     1860

gatgagtgcc tgagtgaccc atgtcccgtt ggagccagct gccttgatct tccaggagcc     1920

ttcttttgcc tctgcccctc tggtttcaca ggccagctct gtgaggttcc cctgtgtgct     1980

cccaacctgt gccagcccaa gcagatatgt aaggaccaga aagacaaggc caactgcctc     2040

tgtcctgatg gaagccctgg ctgtgcccca cctgaggaca actgcacctg ccaccacggg     2100

cactgccaga gatcctcatg tgtgtgtgac gtgggttgga cggggccaga gtgtgaggca     2160

gagctagggg gctgcatctc tgcaccctgt gcccatgggg ggacctgcta cccccagccc     2220

tctggctaca actgcacctg ccctacaggc tacacaggac ccacctgtag tgaggagatg     2280

acagcttgtc actcagggcc atgtctcaat ggcggctcct gcaaccctag ccctggaggc     2340

tactactgca cctgccctcc aagccacaca gggccccagt gccaaaccag cactgactac     2400

tgtgtgtctg ccccgtgctt caatgggggt acctgtgtga acaggcctgg caccttctcc     2460

tgcctctgtg ccatgggctt ccagggcccg cgctgtgagg gaaagctccg ccccagctgt     2520

gcagacagcc cctgtaggaa tagggcaacc tgccaggaca gccctcaggg tccccgctgc     2580

ctctgcccca ctggctacac cggaggcagc tgccagactc tgatggactt atgtgcccag     2640

aagccctgcc cacgcaattc ccactgcctc cagactgggc cctccttcca ctgcttgtgc     2700

ctccagggat ggaccgggcc tctctgcaac cttccactgt cctcctgcca gaaggctgca     2760

ctgagccaag gcatagacgt ctcttccctt tgccacaatg gaggcctctg tgtcgacagc     2820

ggcccctcct atttctgcca ctgcccccct ggattccaag gcagcctgtg ccaggatcac     2880

gtgaacccat gtgagtccag gccttgccag aacggggcca cctgcatggc ccagcccagt     2940

gggtatctct gccagtgtgc cccaggctac gatggacaga actgctcaaa ggaactcgat     3000

gcttgtcagt cccaaccctg tcacaaccat ggaacctgta ctcccaaacc tggaggattc     3060

cactgtgcct gccctccagg ctttgtgggg ctacgctgtg agggagacgt ggacgagtgt     3120

ctggaccagc cctgccaccc cacaggcact gcagcctgcc actctctggc caatgccttc     3180

tactgccagt gtctgcctgg acacacaggc cagtggtgtg aggtggagat agacccctgc     3240

cacagccaac cctgctttca tggagggacc tgtgaggcca cagcaggatc acccctgggt     3300

ttcatctgcc actgccccaa gggttttgaa ggccccacct gcagccacag ggccccttcc     3360

tgcggcttcc atcactgcca ccacggaggc ctgtgtctgc cctcccctaa gccaggcttc     3420

ccaccacgct gtgcctgcct cagtggctat gggggtcctg actgcctgac cccaccagct     3480

cctaaaggct gtggccctcc ctccccatgc ctatacaatg gcagctgctc agagaccacg     3540

ggcttggggg gcccaggctt tcgatgctcc tgccctcaca gctctccagg gccccggtgt     3600

cagaaacccg gagccaaggg gtgtgagggc agaagtggag atggggcctg cgatgctggc     3660

tgcagtggcc cgggaggaaa ctgggatgga ggggactgct ctctgggagt cccagacccc     3720

tggaagggct gcccctccca ctctcggtgc tggcttctct tccgggacgg gcagtgccac     3780

ccacagtgtg actctgaaga gtgtctgttt gatggctacg actgtgagac ccctccagcc     3840

tgcactccag cctatgacca gtactgccat gatcacttcc acaacgggca ctgtgagaaa     3900

ggctgcaaca ctgcagagtg tggctgggat ggaggtgact gcaggcctga agatggggac     3960

ccagagtggg ggccctccct ggccctgctg gtggtactga gccccccagc cctagaccag     4020

cagctgtttg ccctggcccg ggtgctgtcc ctgactctga gggtaggact ctgggtaagg     4080

aaggatcgtg atggcaggga catggtgtac ccctatcctg gggcccgggc tgaagaaaag     4140

ctaggaggaa ctcgggaccc cacctatcag gagagagcag cccctcaaac gcagcccctg     4200

ggcaaggaga ccgactccct cagtgctggg ttcgtggtgg tcatgggtgt ggatttgtcc     4260

cgctgtggcc ctgaccaccc ggcatcccgc tgtccctggg accctgggct tctactccgc     4320

ttccttgctg cgatggctgc agtgggagcc ctggagcccc tgctgcctgg accactgctg     4380

gctgtccacc ctcatgcagg gaccgcaccc cctgccaacc agcttccctg gcctgtgctg     4440

tgctccccag tggccggggt gattctcctg gccctagggg ctcttctcgt cctccagctc     4500

atccggcgtc gacgccgaga gcatggagct ctctggctgc cccctggttt cactcgacgg     4560

cctcggactc agtcagctcc ccaccgacgc cggcccccac taggcgagga cagcattggt     4620

ctcaaggcac tgaagccaaa ggcagaagtt gatgaggatg gagttgtgat gtgctcaggc     4680

cctgaggagg gagaggaggt gggccaggct gaagaaacag gcccaccctc cacgtgccag     4740

ctctggtctc tgagtggtgg ctgtggggcg ctccctcagg cagccatgct aactcctccc     4800

caggaatctg agatggaagc ccctgacctg gacacccgtg gacctgatgg ggtgacaccc     4860

ctgatgtcag cagtttgctg tggggaagta cagtccggga ccttccaagg ggcatggttg     4920

ggatgtcctg agccctggga acctctgctg gatggagggg cctgtcccca ggctcacacc     4980

gtgggcactg gggagacccc cctgcacctg gctgcccgat tctcccggcc aaccgctgcc     5040

cgccgcctcc ttgaggctgg agccaacccc aaccagccag accgggcagg gcgcacaccc     5100

cttcatgctg ctgtggctgc tgatgctcgg gaggtctgcc agcttctgct ccgtagcaga     5160

caaactgcag tggacgctcg cacagaggac gggaccacac ccttgatgct ggctgccagg     5220

ctggcggtgg aagacctggt tgaagaactg attgcagccc aagcagacgt gggggccaga     5280

gataaatggg ggaaaactgc gctgcactgg gctgctgccg tgaacaacgc ccgagccgcc     5340

cgctcgcttc tccaggccgg agccgataaa gatgcccagg acaacaggga gcagacgccg     5400

ctattcctgg cggcgcggga aggagcggtg gaagtagccc agctactgct ggggctgggg     5460

gcagcccgag agctgcggga ccaggctggg ctagcgccgg cggacgtcgc tcaccaacgt     5520

aaccactggg atctgctgac gctgctggaa ggggctgggc caccagaggc ccgtcacaaa     5580

gccacgccgg gccgcgaggc tgggcccttc ccgcgcgcac ggacggtgtc agtaagcgtg     5640

cccccgcatg ggggcggggc tctgccgcgc tgccggacgc tgtcagccgg agcaggccct     5700

cgtgggggcg gagcttgtct gcaggctcgg acttggtccg tagacttggc tgcgcggggg     5760

ggcggggcct attcgcattg ccggagcctc tcgggagtag gagcaggagg aggcccgacc     5820

cctcgcggcc gtaggttttc tgcaggcatg cgcgggcctc ggcccaaccc tgcgataatg     5880

cgaggaagat acggagtggc tgccgggcgc ggaggcaggg tctcaacgga tgactggccc     5940

tgtgattggg tggccctggg agcttgcggt tctgcctcca acattccgat cccgcctcct     6000

tgccttactc cgtccccgga gcggggatca cctcaacttg actgtggtcc cccagccctc     6060

caagaaatgc ccataaacca aggaggagag ggtaaaaaat agaagaatac atggtaggga     6120

gg                                                                    6122


<210> 15
<211> 834
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15      


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60                  


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80  


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95      


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110         


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125             


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140                 


Thr Ser Gly Pro His Val Gly Lys Lys Val Ile Thr Pro Val Arg Thr 
145                 150                 155                 160 


Gly His Gly Tyr Val Tyr Glu Tyr Pro Ser Arg Tyr Gln Lys Asp Val 
                165                 170                 175     


Tyr Asp Ile Pro Pro Ser His Thr Thr Gln Gly Val Tyr Asp Ile Pro 
            180                 185                 190         


Pro Ser Ser Ala Lys Gly Pro Val Phe Ser Val Pro Val Gly Glu Ile 
        195                 200                 205             


Lys Pro Gln Gly Val Tyr Asp Ile Pro Pro Thr Lys Gly Val Tyr Ala 
    210                 215                 220                 


Ile Pro Pro Ser Ala Cys Arg Asp Glu Ala Gly Leu Arg Glu Lys Asp 
225                 230                 235                 240 


Tyr Asp Phe Pro Pro Pro Met Arg Gln Ala Gly Arg Pro Asp Leu Arg 
                245                 250                 255     


Pro Glu Gly Val Tyr Asp Ile Pro Pro Thr Cys Thr Lys Pro Ala Gly 
            260                 265                 270         


Lys Asp Leu His Val Lys Tyr Asn Cys Asp Ile Pro Gly Ala Ala Glu 
        275                 280                 285             


Pro Val Ala Arg Arg His Gln Ser Leu Ser Pro Asn His Pro Pro Pro 
    290                 295                 300                 


Gln Leu Gly Gln Ser Val Gly Ser Gln Asn Asp Ala Tyr Asp Val Pro 
305                 310                 315                 320 


Arg Gly Val Gln Phe Leu Glu Pro Pro Ala Glu Thr Ser Glu Lys Ala 
                325                 330                 335     


Asn Pro Gln Glu Arg Asp Gly Val Tyr Asp Val Pro Leu His Asn Pro 
            340                 345                 350         


Pro Asp Ala Lys Gly Ser Arg Asp Leu Val Asp Gly Ile Asn Arg Leu 
        355                 360                 365             


Ser Phe Ser Ser Thr Gly Ser Thr Arg Ser Asn Met Ser Thr Ser Ser 
    370                 375                 380                 


Thr Ser Ser Lys Glu Ser Ser Leu Ser Ala Ser Pro Ala Gln Asp Lys 
385                 390                 395                 400 


Arg Leu Phe Leu Asp Pro Asp Thr Ala Ile Glu Arg Leu Gln Arg Leu 
                405                 410                 415     


Gln Gln Ala Leu Glu Met Gly Val Ser Ser Leu Met Ala Leu Val Thr 
            420                 425                 430         


Thr Asp Trp Arg Cys Tyr Gly Tyr Met Glu Arg His Ile Asn Glu Ile 
        435                 440                 445             


Arg Thr Ala Val Asp Lys Val Glu Leu Phe Leu Lys Glu Tyr Leu His 
    450                 455                 460                 


Phe Val Lys Gly Ala Val Ala Asn Ala Ala Cys Leu Pro Glu Leu Ile 
465                 470                 475                 480 


Leu His Asn Lys Met Lys Arg Glu Leu Gln Arg Val Glu Asp Ser His 
                485                 490                 495     


Gln Ile Leu Ser Gln Thr Ser His Asp Leu Asn Glu Cys Ser Trp Ser 
            500                 505                 510         


Leu Asn Ile Leu Ala Ile Asn Lys Pro Gln Asn Lys Cys Asp Asp Leu 
        515                 520                 525             


Asp Arg Phe Val Met Val Ala Lys Thr Val Pro Asp Asp Ala Lys Gln 
    530                 535                 540                 


Leu Thr Thr Thr Ile Asn Thr Asn Ala Glu Ala Leu Phe Arg Pro Gly 
545                 550                 555                 560 


Pro Gly Ser Leu His Leu Lys Asn Gly Pro Glu Ser Ile Met Asn Ser 
                565                 570                 575     


Thr Glu Tyr Pro His Gly Gly Ser Gln Gly Gln Leu Leu His Pro Gly 
            580                 585                 590         


Asp His Lys Ala Gln Ala His Asn Lys Ala Leu Pro Pro Gly Leu Ser 
        595                 600                 605             


Lys Glu Gln Ala Pro Asp Cys Ser Ser Ser Asp Gly Ser Glu Arg Ser 
    610                 615                 620                 


Trp Met Asp Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe 
625                 630                 635                 640 


Glu Arg Gln Gln Lys Glu Leu Leu Glu Lys Glu Asn Ile Met Lys Gln 
                645                 650                 655     


Asn Lys Met Gln Leu Glu His His Gln Leu Ser Gln Phe Gln Leu Leu 
            660                 665                 670         


Glu Gln Glu Ile Thr Lys Pro Val Glu Asn Asp Ile Ser Lys Trp Lys 
        675                 680                 685             


Pro Ser Gln Ser Leu Pro Thr Thr Asn Ser Gly Val Ser Ala Gln Asp 
    690                 695                 700                 


Arg Gln Leu Leu Cys Phe Tyr Tyr Asp Gln Cys Glu Thr His Phe Ile 
705                 710                 715                 720 


Ser Leu Leu Asn Ala Ile Asp Ala Leu Phe Ser Cys Val Ser Ser Ala 
                725                 730                 735     


Gln Pro Pro Arg Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
            740                 745                 750         


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Thr Arg Gln Val Thr 
        755                 760                 765             


Ala Gln Asp Ile Arg Asn Lys Val Met Asn Ser Ser Asn Gln Leu Cys 
    770                 775                 780                 


Glu Gln Leu Lys Thr Ile Val Met Ala Thr Lys Met Ala Ala Leu His 
785                 790                 795                 800 


Tyr Pro Ser Thr Thr Ala Leu Gln Glu Met Val His Gln Val Thr Asp 
                805                 810                 815     


Leu Ser Arg Asn Ala Gln Leu Phe Lys Arg Ser Leu Leu Glu Met Ala 
            820                 825                 830         


Thr Phe 
        


<210> 16
<211> 4532
<212> DNA
<213> Homo sapiens

<400> 16
agtgacttga gggaggcgct gcgactgaca agcggctctg cccgggacct tctcgctttc       60

atctagcgct gcactcaatg gaggggcggg caccgcagtg cttaatgctg tcttaactag      120

tgtaggaaaa cggctcaacc caccgctgcc gaaatgaagt ataagaatct tatggcaagg      180

gccttatatg acaatgtccc agagtgtgcc gaggaactgg cctttcgcaa gggagacatc      240

ctgaccgtca tagagcagaa cacaggggga ctggaaggat ggtggctgtg ctcgttacac      300

ggtcggcaag gcattgtccc aggcaaccgg gtgaagcttc tgattggtcc catgcaggag      360

actgcctcca gtcacgagca gcctgcctct ggactgatgc agcagacctt tggccaacag      420

aagctctatc aagtgccaaa cccacaggct gctccccgag acaccatcta ccaagtgcca      480

ccttcctacc aaaatcaggg aatttaccaa gtccccactg gccacggcac ccaagaacaa      540

gaggtatatc aggtgccacc atcagtgcag agaagcattg ggggaaccag tgggccccac      600

gtgggtaaaa aggtgataac ccccgtgagg acaggccatg gctacgtata cgagtaccca      660

tccagatacc aaaaggacgt ctatgatatc cctccttctc ataccactca aggggtatac      720

gacatccctc cctcatcagc aaaaggccct gtgttttcag ttccagtggg agagataaaa      780

cctcaagggg tgtatgacat cccgcctaca aaaggggtat atgccattcc gccctctgct      840

tgccgggatg aagcagggct tagggaaaaa gactatgact tcccccctcc catgagacaa      900

gctggaaggc cggacctcag accggagggg gtttatgaca ttcctccaac ctgcaccaag      960

ccagcaggga aggaccttca tgtaaaatac aactgtgaca ttccaggagc tgcagaaccg     1020

gtggctcgaa ggcaccagag cctgtccccg aatcacccac ccccgcaact cggacagtca     1080

gtgggctctc agaacgacgc atatgatgtc ccccgaggcg ttcagtttct tgagccacca     1140

gcagaaacca gtgagaaagc aaacccccag gaaagggatg gtgtttatga tgtccctctg     1200

cataacccgc cagatgctaa aggctctcgg gacttggtgg atgggatcaa ccgattgtct     1260

ttctccagta caggcagcac ccggagtaac atgtccacgt cttccacctc ctccaaggag     1320

tcctcactgt cagcctcccc agctcaggac aaaaggctct tcctggatcc agacacagct     1380

attgagagac ttcagcggct ccagcaggcc cttgagatgg gtgtctccag cctaatggca     1440

ctggtcacta ccgactggcg gtgttacgga tatatggaaa gacacatcaa tgaaatacgc     1500

acagcagtgg acaaggtgga gctgttcctg aaggagtacc tccactttgt caagggagct     1560

gttgcaaatg ctgcctgcct cccggaactc atcctccaca acaagatgaa gcgggagctg     1620

caacgagttg aagactccca ccagatcctg agtcaaacca gccatgactt aaatgagtgc     1680

agctggtccc tgaatatctt ggccatcaac aagccccaga acaagtgtga cgatctggac     1740

cggtttgtga tggtggcaaa gacggtgccc gatgacgcca agcagctcac cacaaccatc     1800

aacaccaacg cagaggccct cttcagaccc ggccctggca gcttgcatct gaagaatggg     1860

ccggagagca tcatgaactc aacggagtac ccacacggtg gctcccaggg acagctgctg     1920

catcctggtg accacaaggc ccaggcccac aacaaggcac tgcccccagg cctgagcaag     1980

gagcaggccc ctgactgtag cagcagtgat ggttctgaga ggagctggat ggatgactac     2040

gattacgtcc acctacaggg taaggaggag tttgagaggc aacagaaaga gctattggaa     2100

aaagagaata tcatgaaaca gaacaagatg cagctggaac atcatcagct gagccagttc     2160

cagctgttgg aacaagagat tacaaagccc gtggagaatg acatctcgaa gtggaagccc     2220

tctcagagcc tacccaccac aaacagtggc gtgagtgctc aggatcggca gttgctgtgc     2280

ttctactatg accaatgtga gacccatttc atttcccttc tcaacgccat tgacgcactc     2340

ttcagttgtg tcagctcagc ccagcccccg cgaatcttcg tggcacacag caagtttgtc     2400

atcctcagtg cacacaaact ggtgttcatt ggagacacgc tgacacggca ggtgactgcc     2460

caggacattc gcaacaaagt catgaactcc agcaaccagc tctgcgagca gctcaagacc     2520

atagtcatgg caaccaagat ggccgccctc cattacccca gcaccacggc cctgcaggaa     2580

atggtgcacc aagtgacaga cctttctaga aatgcccagc tgttcaagcg ctctttgctg     2640

gagatggcaa cgttctgaga agaaaaaaaa gaggaagggg actgcgttaa cggttactaa     2700

ggaaaactgg aaatactgtc tggtttttgt aaatgttatc tatttttgta gatattttat     2760

ataaaaatga aatattttaa cattttatgg gtcagtcaac tttcagaaat tcagggagct     2820

ggagagggaa atcttttttt ttccccctga gtggttctta tgtacataga ggtatctgag     2880

acataaactg tacagaaaac ttgtccacgt gcttttgtat gcccatgtat tcatgtttgt     2940

ttgtagatgt ttgtctgatg catttcatta aaaaaaaaac catgaattac gaagcacctt     3000

agtaagcacc tcctaatgct gcattttttt tgttgttgtt aaaaacatac cagctggtta     3060

taatattgtt ctccacgtcc ttgtgatgat tctgagcctg gcactcccaa atctgggaag     3120

catagtttat ttgcaagtgt tcaccttcca aatcatgagg catagcatga cttattcttg     3180

tttggaaaac tcttttcaaa actgaccatc ttaaacacat gatggccaag tgcccaaaag     3240

ccctcttgcg gagcaaattt cagaatatat atgtggatcc aagctctgat agttcaggtg     3300

ctggagggaa gagagacctg tgtgtttaga ggccaggacc acagttagga ttgggttgtt     3360

tcaatactga gagacagcta caataaaagg agagcaattg cctccctggg gctgttcaat     3420

cttctgcatt tgtgagtggt tcagtcatga ggttttccaa aagatgtttt tagagttgta     3480

aaaaccatat ttgcagcaaa gatttacaaa ggcgtatcag actatgattg ttcaccaaaa     3540

taggggaatg gtttgatccg ccagttgcaa gtagaggcct ttctgactct taatattcac     3600

tttggtgcta ctacccccat tacctgaggg aaactggcca ggtccttgat catggaacta     3660

tagagctacc aggacatatc ctgctctcta agggaattta ttgctatctt gcaccttctt     3720

taaaactcac atatgcagac ctgacactca agagtggcta gctacacaga gtccatctaa     3780

tttttgcaac ttcctgtggc cagtgtgtat aaccccttcc actatctcac agatagtcac     3840

agcgtccatt ccatagtctg tctcctcaca tctgttagta ttgacacagc acagacacca     3900

caagccatca ggttcttcat ggggcaggtg aaatacttct accccatggg taaatgtatt     3960

cacatattac caagagaaga agcacattat ctatgatctt ttggcccagt tcttatttag     4020

catttttatt ccagcctact tggaaacatg tttttatttg caatatatgc ctgactgaat     4080

taagcttgct tgttttaaac aaccaaatca ttggaacaga aaaggattta aaaaacaaga     4140

atgcatgatc tcagagtgat taaaaaaaaa tcagtggaaa taaatgatca tagaaggtgc     4200

ttttcaaaac aactgctatt ataattctca aagtcctact ctgccaaaag aagattaaaa     4260

gtcatacatt acattacaag gaaatgttca tgtgggaaga gggttgctga aaatcaacaa     4320

cgcttgaagt taaaaagtgt gtctttgtag atttcattgt ataatgtgta tttcttagga     4380

gatggctgac ttgattgatc tacgctaagt ggagacattt cacattttta aaaccaaatg     4440

ttcaatctgt attactcttt gccgtcttgt atgtagaggc tatttttaaa tcattaaatt     4500

tttagatctc tgttttcaaa aaaaaaaaaa aa                                   4532


<210> 17
<211> 1252
<212> PRT
<213> Homo sapiens

<400> 17
Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu His Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Arg Phe Arg 
        595                 600                 605             


Arg Met Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Pro Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Thr Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Glu 
865                 870                 875                 880 


Gln Gly Asp Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Ser 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Gly  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  His Ser Ser Cys Thr  Arg Arg Asn 
    1235                 1240                 1245             


Ala Thr  Arg Gly 
    1250         


<210> 18
<211> 8707
<212> DNA
<213> Homo sapiens

<400> 18
gaggatcacg tggcgcggcg ccgcggccga agcagaagta gcgagcgccg gcggcggagg       60

gcgtgagcgg cgctgagtga cccgagtcgg gacgcgggct gcgcgcgcgg gaccccggag      120

cccaaacccg gggcaggcgg gcagctgtgc ccgggcggca cggccagctt cctgatttct      180

cccgattcct tccttctccc tggagcggcc gacaatgtcc accacggtca atgtagattc      240

ccttgcggaa tatgagaaga gccagatcaa gagagccctg gagctgggga cggtgatgac      300

tgtgttcagc ttccgcaagt ccacccccga gcggagaacc gtccaggtga tcatggagac      360

gcggcaggtg gcctggagca agaccgctga caagatcgag ggcttcttgg atatcatgga      420

aataaaagaa atccgcccag ggaagaactc caaagatttc gagcgagcaa aagcagttcg      480

ccagaaagaa gactgctgct tcaccatcct atatggcact cagttcgtcc tcagcacgct      540

cagcttggca gctgactcta aagaggatgc agttaactgg ctctctggct tgaaaatctt      600

acaccaggaa gcgatgaatg cgtccacgcc caccattatc gagagttggc tgagaaagca      660

gatatattct gtggatcaaa ccagaagaaa cagcatcagt ctccgagagt tgaagaccat      720

cttgcccctg atcaacttta aagtgagcag tgccaagttc cttaaagata agtttgtgga      780

aataggagca cacaaagatg agctcagctt tgaacagttc catctcttct ataaaaaact      840

tatgtttgaa cagcaaaaat cgattctcga tgaattcaaa aaggattcgt ccgtgttcat      900

cctggggaac actgacaggc cggatgcctc tgctgtttac ctgcatgact tccagaggtt      960

tctcatacat gaacagcagg agcattgggc tcaggatctg aacaaagtcc gtgagcggat     1020

gacaaagttc attgatgaca ccatgcgtga aactgctgag cctttcttgt ttgtggatga     1080

gttcctcacg tacctgtttt cacgagaaaa cagcatctgg gatgagaagt atgacgcggt     1140

ggacatgcag gacatgaaca accccctgtc tcattactgg atctcctcgt cacataacac     1200

gtaccttaca ggtgaccagc tgcggagcga gtcgtcccca gaagcttaca tccgctgcct     1260

gcgcatgggc tgtcgctgca ttgaactgga ctgctgggac gggcccgatg ggaagccggt     1320

catctaccat ggctggacgc ggactaccaa gatcaagttt gacgacgtcg tgcaggccat     1380

caaagaccac gcctttgtta cctcgagctt cccagtgatc ctgtccatcg aggagcactg     1440

cagcgtggag caacagcgtc acatggccaa ggccttcaag gaagtatttg gcgacctgct     1500

gttgacgaag cccacggagg ccagtgctga ccagctgccc tcgcccagcc agctgcggga     1560

gaagatcatc atcaagcata agaagctggg cccccgaggc gatgtggatg tcaacatgga     1620

ggacaagaag gacgaacaca agcaacaggg ggagctgtac atgtgggatt ccattgacca     1680

gaaatggact cggcactact gcgccattgc cgatgccaag ctgtccttca gtgatgacat     1740

tgaacagact atggaggagg aagtgcccca ggatataccc cctacagaac tacattttgg     1800

ggagaaatgg ttccacaaga aggtggagaa gaggacgagt gccgagaagt tgctgcagga     1860

atactgcatg gagacggggg gcaaggatgg caccttcctg gttcgggaga gcgagacctt     1920

ccccaatgac tacaccctgt ccttctggcg gtcaggccgg gtccagcact gccggatccg     1980

ctccaccatg gagggcggga ccctgaaata ctacttgact gacaacctca ccttcagcag     2040

catctatgcc ctcatccagc actaccgcga gacgcacctg cgctgcgccg agttcgagct     2100

gcggctcacg gaccctgtgc ccaaccccaa cccccacgag tccaagccgt ggtactatga     2160

cagcctgagc cgcggagagg cagaggacat gctgatgagg attccccggg acggggcctt     2220

cctgatccgg aagcgagagg ggagcgactc ctatgccatc accttcaggg ctaggggcaa     2280

ggtaaagcat tgtcgcatca accgggacgg ccggcacttt gtgctgggga cctccgccta     2340

ttttgagagt ctggtggagc tcgtcagtta ctacgagaag cattcactct accgaaagat     2400

gagactgcgc taccccgtga cccccgagct cctggagcgc tacaatatgg aaagagatat     2460

aaactccctc tacgacgtca gcagaatgta tgtggatccc agtgaaatca atccgtccat     2520

gcctcagaga accgtgaaag ctctgtatga ctacaaagcc aagcgaagcg atgagctgag     2580

cttctgccgt ggtgccctca tccacaatgt ctccaaggag cccgggggct ggtggaaagg     2640

agactatgga accaggatcc agcagtactt cccatccaac tacgtcgagg acatctcaac     2700

tgcagacttc gaggagctag aaaagcagat tattgaagac aatcccttag ggtctctttg     2760

cagaggaata ttggacctca atacctataa cgtcgtgaaa gcccctcagg gaaaaaacca     2820

gaagtccttt gtcttcatcc tggagcccaa gcagcagggc gatcctccgg tggagtttgc     2880

cacagacagg gtggaggagc tctttgagtg gtttcagagc atccgagaga tcacctggaa     2940

gattgacacc aaggagaaca acatgaagta ctgggagaag aaccagtcca tcgccatcga     3000

gctctctgac ctggttgtct actgcaaacc aaccagcaaa accaaggaca acttagaaaa     3060

tcctgacttc cgagaaatcc gctcctttgt ggagacgaag gctgacagca tcatcagaca     3120

gaagcccgtc gacctcctga agtacaatca aaagggcctg acccgcgtct acccaaaggg     3180

acaaagagtt gactcttcaa actacgaccc cttccgcctc tggctgtgcg gttctcagat     3240

ggtggcactc aatttccaga cggcagataa gtacatgcag atgaatcacg cattgttttc     3300

tctcaatggg cgcacgggct acgttctgca gcctgagagc atgaggacag agaaatatga     3360

cccgatgcca cccgagtccc agaggaagat cctgatgacg ctgacagtca aggttctcgg     3420

tgctcgccat ctccccaaac ttggacgaag tattgcctgt ccctttgtag aagtggagat     3480

ctgtggagcc gagtatgaca acaacaagtt caagacgacg gttgtgaatg ataatggcct     3540

cagccctatc tgggctccaa cacaggagaa ggtgacattt gaaatttatg acccaaacct     3600

ggcatttctg cgctttgtgg tttatgaaga agatatgttc agcgatccca actttcttgc     3660

tcatgccact taccccatta aagcagtcaa atcaggattc aggtccgttc ctctgaagaa     3720

tgggtacagc gaggacatag agctggcttc cctcctggtt ttctgtgaga tgcggccagt     3780

cctggagagc gaagaggaac tttactcctc ctgtcgccag ctgaggaggc ggcaagaaga     3840

actgaacaac cagctctttc tgtatgacac acaccagaac ttgcgcaatg ccaaccggga     3900

tgccctggtt aaagagttca gtgttaatga gaaccagctc cagctgtacc aggagaaatg     3960

caacaagagg ttaagagaga agagagtcag caacagcaag ttttactcat agaagctggg     4020

gtatgtgtgt aagggtattg tgtgtgtgcg catgtgtgtt tgcatgtagg agaacgtgcc     4080

ctattcacac tctgggaaga cgctaatctg tgacatcttt tcttcaagcc tgccatcaag     4140

gacatttctt aagacccaac tggcatgagt tggggtaatt tcctattatt ttcatcttgg     4200

acaactttct taacttatat tctttataga ggattcccca aaatgtgctc ctcatttttg     4260

gcctctcatg ttccaaacct cattgaataa aagcaatgaa aaccttgatc aattaagcct     4320

tctgttgcac gacctgtgca gtgaacagga tttcttttct ggccaagaag attctacctc     4380

taatgatcca ggtaactgat gtccatggag gatgagctgg aaatgtaaga aactattcat     4440

gagattctga aaaggatttt aactcaaagg caaatgattc cataagggcc caaagagaag     4500

ccctacccac aggcagcctg ctcagttcaa tgtactttaa ctaccaccgg ctgcctgctg     4560

cagtccacaa gaaaatggct gagtgatggg atctgttcat taagacaatt tctaattaat     4620

ggtgacagct tgttttgtga ctagagttac tgggatggag ggtaggaatc ttggggcctc     4680

tttgttttaa aaagcccatc agagagacca gagccgtgct gcaggggcag gttctcactt     4740

gcccctggct ctgccagctg ctgggaggct ctggccccac tagtccctca tggccctact     4800

gaactggctg ggaggctgct ggaatggccc ttggtccaca gctctccaca ggcaagaggt     4860

caactgctgc ttgaaagagg tagacaaaag ttaggttgat ggcgaaatgt ctctgggtta     4920

cccagtcttc tggagcagca agctgagctt taatgggcta agcattaggg tgttacagaa     4980

aatttcaaat gcagccatct cccttggggc agatctacct agttcatgac agtatgtgcg     5040

gctggccagg gctttacacc tctgcatctt aagttgttaa tacataccaa taatgtaata     5100

tggcttttta aaggagagga gagtgctggg ttgggaaggg aggtggttgg tagagtcaca     5160

acttctcaat gagtgaattt acagctgatg ggaaaaggag tgtaactgtg aaaaacgatg     5220

gctgtggtgg ggaagaacaa accagcagta agcctgatgt ttgatgtgga tggaactggc     5280

ccctagaaac ccatctgacc ctcctcttgt tacccgaaat gctgggctta gtatgcatgt     5340

actgctgaaa agcagggcag aacaaatcag gctctgacca gaagatcctt ctggtccctt     5400

cactctacaa aaacttactg atcacctcca catgccaaat acagtgccaa gatttggggg     5460

tgtggatgtt taaacaaaaa gctgtgggtc tcatcaatca tctccatcca caagctccta     5520

aaagaaagcc atttacctcg cttgaagcca ggaacacagg gaacagcagt ctggccaagg     5580

aagggctgtt atctggtgct atcactccag ttactcctcc aactgggagc tgctatttta     5640

tttggcagtc agcaactgaa gaaagaacat tcctcttagt ggcagatgtt caaagcaact     5700

ttcaagaaag gctaggtgag aaaggcactg ggatgagtgc tgcaggcact ctgtagccag     5760

ggccccatta gcctttggcc aggtagccac cagaacctat ttattgcacc tggcatctcc     5820

cccaacccct ctcagctctg ttaggacttc cacacagcag agctcaggtg ttgctgtcat     5880

tacctccttt cagctcctca cttcattcta ctttaaagcc acagtgctaa ggcctgcatc     5940

ccctttctgc ccaaatgggt tttttgctac catatcaaag aacctgacat atggcggcat     6000

aggaagcaga agctaagcct ctctccagct gctgctgtgt aaaatccatg cgtggccaaa     6060

gagaagtcag gggattatga cataaatggt gctgggaaga accctctgcc taaaactgtc     6120

tccttctcct ggtgctacaa ccggaatcca ccatgagaga gtactttctt cggttctttc     6180

ctcctgtcct tgacagagta acacgttaat ctggttcttg gtggtgttag ggactgattc     6240

tctcaggaaa ggcacacatg gtatgatggc tcttcccaga gtctatgtga tgctacataa     6300

cttcagtatc tagctgagac atgcttccta catgactgtt aaagcacagc caatccaggc     6360

caagaagact agtaacaggc acattctgaa agatggaagc agcactgata gatcaaaacc     6420

accactgcat atgtattaca ctgtttttgt tcaccatttt cctaagtgtg ttatttagaa     6480

tattggttat tacaaggaaa aataaagtgg ggaggctggt taggccttgt gagtttggga     6540

aacttaggtt ataaaaacta aataaagttt ttctactgtg agactagatg tgcaggagtg     6600

aaaggtgtag agggtcttgt tttccaaatt cgatctcaga atctttttgc cagaagtgtc     6660

tcatgggact tatctatagt ggaacacatt tgaagaccta ctgctctatt aagaaggcag     6720

ccggacaaca tgttctaata cttcgtatgc tttgtgacct agttaaaatc taaacttaag     6780

tcgccatggc cagtggcctt tagattaagc tagccttacc cctgggagta taccagagct     6840

ttccaaggaa tacacagact ccagtactct caggggagca gtgttcagag cctcatcttc     6900

ctgttatatt cttctctaag attcatctgc ctgagaaaat gcccttttct caccttacaa     6960

aagaaaatat ggctgtctcc acctctagtc ttactgtaga gcatgtccca aggtgtaaaa     7020

attcaaaatg tggatatttg gaaagtgaaa gacttatcaa cagggcacaa atctttttgc     7080

aaatggattt tccaagtttt tctggtggtt ccaaattttt tgctttcaac aaagtgggag     7140

gaacagcctg tagatttctg agtctcttag catgtaacta caaaggggtt ggaagaattc     7200

agtgattctg ctatcataaa gcttccgttc ccattgatgt atctgtgtga acaaggatca     7260

acatctccat aaatgaaatt gaaaacggaa aatagaattg atgatgaact ttggctcaat     7320

cttaagatgt tatcaatcta catagatgaa ataattgtgg agaaaagccc tctttatctc     7380

attaagtgat acatttccaa agaagtttta ctatgtttaa taatttagtg aaatttgggc     7440

tatgtgttta ttgattcagc tcaatccaga ggaaaatttt aaaggcttac agccttagga     7500

ttataggata ctatataata cttttggtac agagatagaa ttaaataaca taaaaatcaa     7560

aaatttatta ggctaaaatt ttgagggaga agtggtatga aaatacaaat tcaaggagta     7620

aaaggaaaag tggggcattc cttgctacta aaaattgcct tgttccaggt aagactgatc     7680

ataaaaaaat ggccctgttc ataaaatttt taaaaagatc atagtatcta tcaaataact     7740

tatattaaga acctcctggg ctaaatttaa aaagtaatac aacagtttta tttaaacatg     7800

tagtgtctac ggtatgccag cactttgcag ctatttataa tgagaaattt tagatgtcaa     7860

tatagcaatg tgcaagaaga tagagatttt caaaattcac ttaagagtat ctgagcataa     7920

aatgttaaga ttgctgatcg gatgtgaggg cgatctggct gcgacatctg tcaccccatt     7980

gatcgccagg gttgattcgg ctgatctggc tggctaggtg ggtgtcccct tcctacctca     8040

ccgctccatg tgcgtccctc ccgaagctgc gcgctccgtc gaagaggacg accaaccccg     8100

atagaggagg accggtcttc ggtcaagggt atacgagtag ctgcgctccc ctgctggaac     8160

ctccaaacaa gctctcaaga ttgctgatct agggccacta agtgatgaat tgtatttgga     8220

agcaaaaagg atggctaaaa aggacctcaa cccttttgac tttaaaagga aaatagctta     8280

accttcaacc tgtgtgacat ttaacttttt gaacccaacc gtaaaagcta tcttctaacc     8340

aacaaaaagt taataattag atttggaatt atacagaatt agaaaattgg catttaaaaa     8400

tactcaataa tttgtccctg gtttttaatt ttcaaaatat tttctttttg aagagccaga     8460

ttccagtgat cctgcctctc agaaatttcc acatttctta tttttcatta ggccttaaga     8520

agctgcattt gtaaacttgt gtttcattat taaagcttaa tttatttttt atataaatag     8580

tatgtgcttt gtgtacatag agaattaagt gaatgagtca cacagatgtt ggctgttgtt     8640

aatgtgaaaa ttaaacagct gtatcacatt ttgaaaaata aaagtttcat ctgaatgaat     8700

atagcaa                                                               8707


<210> 19
<211> 500
<212> PRT
<213> Homo sapiens

<400> 19
Met Asp His Thr Glu Gly Ser Pro Ala Glu Glu Pro Pro Ala His Ala 
1               5                   10                  15      


Pro Ser Pro Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu Thr 
            20                  25                  30          


Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr Val 
        35                  40                  45              


Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu Lys 
    50                  55                  60                  


Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly Trp 
65                  70                  75                  80  


Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln Glu 
                85                  90                  95      


Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu Met 
            100                 105                 110         


Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr Leu 
        115                 120                 125             


Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val Lys 
    130                 135                 140                 


Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys Arg 
145                 150                 155                 160 


Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys Asn 
                165                 170                 175     


Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn Arg 
            180                 185                 190         


Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly Gly 
        195                 200                 205             


Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His Leu 
    210                 215                 220                 


Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp Gly 
225                 230                 235                 240 


Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr Gly 
                245                 250                 255     


Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr Ala 
            260                 265                 270         


Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala Phe 
        275                 280                 285             


Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu Arg 
    290                 295                 300                 


Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys Glu 
305                 310                 315                 320 


Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys Ala 
                325                 330                 335     


Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val Thr 
            340                 345                 350         


Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp Val 
        355                 360                 365             


Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg Val 
    370                 375                 380                 


Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu Ser 
385                 390                 395                 400 


Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp Arg 
                405                 410                 415     


Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn Asp 
            420                 425                 430         


Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu Pro 
        435                 440                 445             


Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala Asn 
    450                 455                 460                 


Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly Ser 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr Ala 
                485                 490                 495     


Thr Val Val Ser 
            500 


<210> 20
<211> 2499
<212> DNA
<213> Homo sapiens

<400> 20
gtgtgcaggg ttccagcgac agcagcactg gactcgtcca gagggcggcg ggtgagcggc       60

tggggccccg tggagccacc atggaccccg caggggcagc agacccctca gtgcctccca      120

atcctttgac tcacctgagc ctgcaggaca gatcagagat gcagctgcag agcgaagccg      180

acaggcggag cctcccgggc acttggacca ggtcatcccc agagcacacc accattctga      240

ggggaggcgt gcgcaggtgc ctgcagcaac agtgtgaaca gactgtgcgg atcctgcatg      300

ccaaggtggc ccagaaatca tacggaaatg agaagcggtt cttctgcccc ccgccctgtg      360

tctacctctc ggggcctggc tggagggtga agccagggca ggatcaagct caccaggcgg      420

gggaaacggg gcccacggtc tgcggttaca tgggactgga cagcgcgtcc ggcagcgcca      480

ctgagacgca gaagctgaat ttcgagcagc agccggactc cagggaattc ggctgcgcca      540

agaccctgta catctcagat gcagacaaga ggaagcactt tcggctggtg ctgcggctgg      600

tgctgcgcgg gggccgggag ctgggtacct tccacagccg ccttatcaag gtcatctcga      660

agccctcgca gaagaagcag tcgctgaaaa acaccgatct gtgcatatcc tccggctcaa      720

aggtctccct cttcaaccgc ctgcgctctc agacggtctc cacacgctac ctctctgtgg      780

aggatggggc ctttgtggcc agtgcacgac agtgggctgc cttcacgctc cacctggctg      840

atgggcactc tgcccaagga gacttcccac cgcgagaggg ctacgttcgc tatggctccc      900

tggtgcagct cgtctgcacg gtcaccggca tcacactacc tcccatgatc atccgtaaag      960

tagcaaaaca gtgtgcgctc cttgatgtgg atgagcccat ctcccagctg cacaagtgtg     1020

cattccagtt tccaggcagt cccccaggag ggggtggcac ctacttatgc cttgccacag     1080

agaaggtggt gcaatttcag gcctctccct gccccaagga ggcgaacagg gctctgctta     1140

acgacagctc ttgctggacc atcatcggca ccgagtcggt ggaattttcc ttcagcacca     1200

gcctggcgtg taccctggag ccggtcactc cggtgcctct catcagcacc ctagagctga     1260

gcggcggggg cgacgtggcc acgctggagc tccacggaga gaacttccac gcggggctca     1320

aggtgtggtt tggggacgtg gaggcagaaa ccatgtacag gagcccgcgg tccctggtgt     1380

gcgtggtgcc ggacgtggcg gccttctgca gcgactggcg ctggctgcgc gctcccatca     1440

caatccccat gagcctggtg cgcgccgacg ggctcttcta ccctagtgcc ttctccttca     1500

cctacacccc ggaatacagc gtgcggccgg gtcaccccgg cgtccccgag cccgccaccg     1560

acgccgacgc gctcctggag agcatccatc aggagttcac gcgcaccaac ttccacctct     1620

tcatccagac ttaggcgcgc ccggtagccc cggctgccca ccctggaggg ctgcgcccgc     1680

gccaggcgcg gggacgtgtt tctgggttct aggccctgct tccttgcccc tttgctgcag     1740

aagggcagct gaaggctcac cctagaaacc gggcctggtg ggtcttaccc ggctcactcc     1800

ctcccttgtc cttacacata caggaagaca agacctgagt ggtgctgtct ttgtgtccgt     1860

cgtgtatggc tctccctgtc ttcatttctt ctcactctgt ctctaaacct ctctctctct     1920

cccttccccc tcagtactta gtctacagac ctatgtgcgt gtccctatcc ttctgtcctt     1980

ttctctcttc agctctccct gcctctcaca cacaatttta catgccccga ggagccaagt     2040

ttgggacatt taccctccag gcatctgtgt cccctcttga agagaaaaca cacagcttca     2100

cacatccagg catagggggc aagctcttgg ggcatcagga ccctggagca ccaggtcctt     2160

cctggaatat tagatccacc tggagcaccg ggtctctcta agtctcacct ggggaattcg     2220

gtcccacctg gggcaccagt tcccacctag agcactgtgt cctgccctag agcacaaaga     2280

cctgctcctc ccgagactct ctctgactgc agccaggcat agtacctttg cctgtgtttg     2340

ctccctggtc cacagatttg gtggctgggc aggtgcctgg acagtgatga ggtcttgccg     2400

ccttaactgt cccccccagt cacttctccc acaggcccag caggacgcag tcctgaggat     2460

cagggattct acagctgcat taaaatcaat cctatccaa                            2499


<210> 21
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
atagcaaata gagttttgtt tccttcccac agatatcaga tttcttcaaa cagtacatag       60

a                                                                       61


<210> 22
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gaaggcctcc acctgagaaa gaggaactag gagttgggtg taaatcagaa accatatgac       60

cagacacact tgagcacact ctgtgagaaa aggga                                  95

