                               SEQUENCE LISTING

<110> BETH ISRAEL DEACONESS MEDICAL CENTER
 
<120> COMPOSITIONS AND METHODS FOR TREATING A TUMOR SUPPRESSOR 
      DEFICIENT CANCER

<130> 167688.010601/PCT

<140> PCT/US2017/049196
<141> 2017-08-29

<150> 62/381,281
<151> 2016-08-30

<160> 79    

<170> PatentIn version 3.5

<210> 1
<211> 119
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Phe 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Ala Leu Pro Leu 
        115                 


<210> 2
<211> 1209
<212> DNA
<213> Homo sapiens

<400> 2
atgacagcca tcatcaaaga gatcgttagc agaaacaaaa ggagatatca agaggatgga       60

ttcgacttag acttgaccta tatttatcca aacattattg ctatgggatt tcctgcagaa      120

agacttgaag gcgtatacag gaacaatatt gatgatgtag taaggttttt ggattcaaag      180

cataaaaacc attacaagat atacaatctt tgtgctgaaa gacattatga caccgccaaa      240

tttaattgca gagttgcaca atatcctttt gaagaccata acccaccaca gctagaactt      300

atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg aagatgacaa tcatgttgca      360

gcaattcact gtaaagctgg aaagggacga actggtgtaa tgatatgtgc atatttatta      420

catcggggca aatttttaaa ggcacaagag gccctagatt tctatgggga agtaaggacc      480

agagacaaaa agggagtaac tattcccagt cagaggcgct atgtgtatta ttatagctac      540

ctgttaaaga atcatctgga ttatagacca gtggcactgt tgtttcacaa gatgatgttt      600

gaaactattc caatgttcag tggcggaact tgcaatcctc agtttgtggt ctgccagcta      660

aaggtgaaga tatattcctc caattcagga cccacacgac gggaagacaa gttcatgtac      720

tttgagttcc ctcagccgtt acctgtgtgt ggtgatatca aagtagagtt cttccacaaa      780

cagaacaaga tgctaaaaaa ggacaaaatg tttcactttt gggtaaatac attcttcata      840

ccaggaccag aggaaacctc agaaaaagta gaaaatggaa gtctatgtga tcaagaaatc      900

gatagcattt gcagtataga gcgtgcagat aatgacaagg aatatctagt acttacttta      960

acaaaaaatg atcttgacaa agcaaataaa gacaaagcca accgatactt ttctccaaat     1020

tttaaggtga agctgtactt cacaaaaaca gtagaggagc cgtcaaatcc agaggctagc     1080

agttcaactt ctgtaacacc agatgttagt gacaacgaac ctgatcatta tagatattct     1140

gacaccactg actctgatcc agagaatgaa ccttttgatg aagatcagca tacacaaatt     1200

acaaaagtc                                                             1209


<210> 3
<211> 403
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210> 4
<211> 6318
<212> DNA
<213> Homo sapiens

<400> 4
actgccgcct cccggcccct cggagggagc cagcccagcc gcagccgccg ccaccgccgc       60

cgccggggcc gggccccctc gccgctgccc cgggaaggag gtctcggcgc ggaagatggc      120

cggcggcgtg gacggcccca tcgggatccc gttccccgac cacagcagcg acatcctgag      180

tgggctgaac gagcagcgga cgcagggcct gctgtgcgac gtggtgatcc tggtggaggg      240

ccgcgagttc cccacgcacc gctcggtgct ggccgcctgc agccagtact tcaagaagct      300

gttcacgtcg ggcgccgtgg tggaccagca gaacgtgtac gagatcgact tcgtcagcgc      360

cgaggcgctc accgcgctca tggacttcgc ctacacggcc acgctcaccg tcagcacagc      420

caacgtgggt gacatcctca gcgccgcccg cctgctggag atccccgccg tgagccacgt      480

gtgcgccgac ctcctggacc ggcagatcct ggcggccgac gcgggcgccg acgccgggca      540

gctggacctt gtagatcaaa ttgatcagcg caacctcctc cgcgccaagg agtacctcga      600

gttcttccag agcaacccca tgaacagcct gccccccgcg gccgccgccg ccgctgccag      660

cttcccgtgg tccgcctttg gggcgtccga tgatgacctg gatgccacca aggaggccgt      720

ggccgccgct gtggccgccg tggccgcggg cgactgcaac ggcttagact tctatgggcc      780

gggccccccg gccgagcggc ccccgacggg ggacggggac gagggcgaca gcaacccggg      840

tctgtggcca gagcgggatg aggacgcccc caccgggggt ctctttccgc cgccggtggc      900

cccgccggcc gccacgcaga acggccacta cggccgcggc ggagaggagg aggccgcctc      960

gctgtcggag gcggcccccg agccgggcga ctctccgggc ttcctgtcgg gagcggccga     1020

gggcgaggac ggggacgggc ccgacgtgga cgggctggcg gccagcacgc tgctgcagca     1080

gatgatgtca tcggtgggcc gggcgggggc cgcggcgggg gacagcgacg aggagtcgcg     1140

ggccgacgac aagggcgtca tggactacta cctgaagtac ttcagcggcg cccacgacgg     1200

cgacgtctac ccggcctggt cgcagaaggt ggagaagaag atccgagcca aggccttcca     1260

gaagtgcccc atctgcgaga aggtcatcca gggcgccggc aagctgccgc gacacatccg     1320

cacccacacg ggcgagaagc cctacgagtg caacatctgc aaggtccgct tcaccaggca     1380

ggacaagctg aaggtgcaca tgcggaagca cacgggcgag aagccgtacc tgtgccagca     1440

gtgcggcgcc gcctttgccc acaactacga cctgaagaac cacatgcgcg tgcacacggg     1500

cctgcgcccc taccagtgcg acagctgctg caagaccttc gtccgctccg accacctgca     1560

cagacacctc aagaaagacg gctgcaacgg cgtcccctcg cgccgcggcc gcaagccccg     1620

cgtccggggc ggggcgcccg accccagccc gggggccacc gcgacccccg gcgcccccgc     1680

ccagcccagc tcccccgacg cccggcgcaa cggccaggag aagcacttta aggacgagga     1740

cgaggacgag gacgtggcca gccccgacgg cttgggccgg ttgaatgtag cgggcgccgg     1800

tggaggaggt gacagcggag gtggccccgg ggccgccacc gacggtaact tcacagccgg     1860

actcgcctaa aaaccaaaaa gagaaaacag aaacccgaga aagagagaga cagagagaga     1920

gaaaaaaaat cacccaccac ccccccaaaa acacaaaaaa agaaaatcta tctatataca     1980

gatatctata tctatatata tatatacaga tatatatata tgacgcgtca cagaatctag     2040

ggtagcgctt tctcagattt ccctcctttc tgacgttttt ctccctccgc aggggccccg     2100

gccctccctg gctccccttc cccccaccac cccatcgctg ggtttcgggg cttggtttgg     2160

ggttttttgt aggacacaag gaatccgaga ccccgcacag ccccctgggc acccggcatg     2220

gggcctgggg cccgatccga ggccctgggc tggggggagg gtagacgtgg gggcgctggg     2280

gggggactgg ggtgggcttt taatttcctc ccctcgctgg tttctatgag tctttcagac     2340

aagaccttaa atgatttctg tctgctctga gcggacgtta aaatgggccc ccgtcccccg     2400

acccgcaccc tccttcctca gggcacttac taagggaggg gtctccctct ccatctcccc     2460

agtggcctcc ccgcctccaa ccctgcctgc ggcctccccc cgtcgcccac cccacgtctc     2520

ctggccactg agacacaaac ctatttattt ctaggcctgg agaaaggaga tcggactggg     2580

gttcccggtg gggcgccagg atggctcctg ggggtgctcc tgccgccttc cttcacggca     2640

cttacaaccg gcgggacccc cagggaccac ccctcagggc gcccccccac ccccgcccgg     2700

tccacctaga cccccacgtt tggagattca aaacttctgt cttcgtcctc tcccccgagc     2760

cccctctccc aaatttttaa agcacttttt agattttttt ttctctttcc tccttaaaaa     2820

caaaatttat atatagatat atatatatat ataaataata tacttttcct cagaggagca     2880

ggcaacagtg tgggataaac agagtcacga tcagaggaac cccagggtct ggtgatggca     2940

gggatggggg gagagagaga aaatccacaa attccaatgt cacaaaagca ataaaacaaa     3000

ctagaaaaaa aaaaggtttt acaaaatgaa aggaaggaaa aaaaaaaagg caaccaacca     3060

cattagaagt cttggcactt tgtaacggaa cgggtactac actttatctt aattcttaat     3120

ttaaaaacat gtttacaagt tacaaccaac ttctatgaaa agttgaaaag acaaaaaaaa     3180

aaaaaaaaag cgagcgagag agagagcgag agagagagcg agagcagaag aaattcctaa     3240

aagtcgattt atttttgtac aaaataataa aaaaaaaaac ccaccacaaa cgtagaatcc     3300

acttctgttc cccaaaaagc gagaaggggg gttcaggagg aagccatcgc aggggacctg     3360

ggagacgccc cgaggtgttt gtgcttcacc cccagacgtc agcctcgaag gcaggactgt     3420

ggggtgttcg tgctgtgttc cccccgctcc ccctttctgt cccctttttt ggttctgacg     3480

tgaagaggtc ttagcgcccg cttctgtcca cggggtctct ccttcctcct ccctagctca     3540

gggatgggcc ttccagccgg agcaccccga tccccatccg gcacccccca atcccccaac     3600

acgcctgtcc ctcccgcatg gccaccaagg agctggacct tggatgcgcc taccctgctg     3660

aggtgggtga caggggcccc ccacctccag ggccttagaa ccaccgcccc tctccccacc     3720

ccaggcaccc ctctttttac tcaaaggcac tgactgtaat ccagggggac tgggacctgc     3780

ctccccccaa cctctggctc ccacaaggcc cggtgttgac cgagccacag gccacggaca     3840

ggggccgggg ttggggagac tatgtcgcca gatgccagga cgccctcacc ccgtttgcat     3900

atgcaatgct agcatgggac cccgaaaata gacgctctgc tgcactgaga cttcttgtca     3960

atgcccaacc ggcggggggg tgtctccctg cccccgaccc ccccataccc ccttctctgt     4020

gacacacaca tcttctcgtc tctttttctt tcattgttaa agggaagctt tttaagaagg     4080

caattttcat attgtttcta caggatggtt ttggttccct tcccttccca ccccccctta     4140

agcctgtcag ccccctccaa atgtctcagg atcccccctc tcccctgggg ctgggtgaca     4200

gcaccccggc tgcgttcaca ccccagtgtc acagggcgag ctgttctgga gagaaaacca     4260

tctgtcgtgg ctgagcgggg agcttgaaca cccaggccag ggacacccct ccccagctcc     4320

cagagaggcc ccctgagggg tgagccctct ttccaccttc ccctatccat gcaccccctc     4380

gcaataaaac caactctaaa atcacagctg tcgtcctagc cagtgggggc gaccggactt     4440

ggggggtgga gccctctggg acttccgtag gaacaagggc tgcggcccac cgcgacactt     4500

acacagacct cggggattgc actaaaccct cgttcctagc tccgcactca gcttcgcctg     4560

tcctgcccgc ccactttgcc ttaactaccc gcccgtcctg ggggccacag cctctgcatg     4620

ggcccagagc cgggaccccc ccagcccagc cccgccctcc ccagactccg cgcaatcaca     4680

tactgtatat agacgtgaat cgattttatt tttattcttt aaattaaggt cgtgataaag     4740

tgttgccaaa gatacctgct gaattctcgc gtttcaggaa acaaacaaac aaaaaaaaat     4800

gatatttgag gagggtcgtg ttgactccat atgaaaggac acagctcaaa gcttttttgt     4860

ttggttgttt ggggtttttt gtgttttctt tttttggggt gttttttttt taactgcctg     4920

gtacaaaaaa aaaaagagaa aaaaaaaaaa gaaaaacaat gcgaaattgt tatttccatt     4980

ctcatggtga agttgcgtgg acgcgtgtgt gcgtgtgtgc aagagagcgg gagtgaggtc     5040

caggctgggg ttggggggct tcaggcgggg gcgcccgggg gccggggagg tggccgggcc     5100

ggagcccccg tctgcagtgc cccccagcct gccgggccca ggagagagag agaagcatct     5160

ttgctactag ctgttgctgc tacctgcctc tgccccccga cgccccccgc cttttgagat     5220

taaggaaaaa aaaaaaaagt caaaaaagtt tttaaaaatg aaaaaaaaaa attataaacc     5280

agtgaatgta aaatgccgga gcaggcccgg cctggcatgg gtgtggacct gcagccaggc     5340

aggctcgagc gggcgatacc aaagtctgcc cccccaccat tgtggccatg cagtcctgtc     5400

actgtctttt tgcttccttc cgaggggggt cccccagcct cttccagggt cttcccctgg     5460

aagtgggcgg ctgcagggaa ggtgggggac aggggtcttt gcacgattca gaccccgggg     5520

ccgtggcagg agcggtcacc tcacaggtgg tgacactgag gcaggggcct cggggtgccc     5580

cctcccgccc ggcaaccaga atggttggag gcaagacaga gagaatgaaa ggaaaaacag     5640

aagaaaaaaa aatattaaaa accaacaaaa aaagcaaaaa tcctattttt tgagaaagaa     5700

agatatttat atttgcagtt ttattttaaa aagttattta agttgaagca gccttcctgg     5760

aggtgggggg gggggggtgg tgggtggctg gcgcaggacg ggtcaggggc ctggaggctg     5820

ggggtgcccc aggagctaca acctcagagt taagactagc tcgcattaaa tacatagatt     5880

tacggggggg gggggggggg gccgggccca gggggtggag ggggccaggg agacccccat     5940

ccctcgccgg ggctgcctgg aggctgtgga ccaggatccg atgcccaggt cccgcccccc     6000

accccacccc aggcccagaa tcgaggtgcc ttggactttg gaggggccag gcctggtgaa     6060

tggggggcgg ggcggcgccc tcagggtaca gagcacagac agatagacat tccagagact     6120

gtattgagag tctttataaa gtgtgggaga tttaaaaaaa aaaaaaactg ataaaaatgc     6180

actttttggg agtggggagg gagaagcttt aaaagtaata aaaaacaaac aaaaacacaa     6240

aagatgaaaa aacaaaaaaa ttcatttttc ttgtacataa aaaaaaaaaa agaaccacta     6300

aacgcagcct gttacgac                                                   6318


<210> 5
<211> 584
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Gly Gly Val Asp Gly Pro Ile Gly Ile Pro Phe Pro Asp His 
1               5                   10                  15      


Ser Ser Asp Ile Leu Ser Gly Leu Asn Glu Gln Arg Thr Gln Gly Leu 
            20                  25                  30          


Leu Cys Asp Val Val Ile Leu Val Glu Gly Arg Glu Phe Pro Thr His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Gln Tyr Phe Lys Lys Leu Phe Thr 
    50                  55                  60                  


Ser Gly Ala Val Val Asp Gln Gln Asn Val Tyr Glu Ile Asp Phe Val 
65                  70                  75                  80  


Ser Ala Glu Ala Leu Thr Ala Leu Met Asp Phe Ala Tyr Thr Ala Thr 
                85                  90                  95      


Leu Thr Val Ser Thr Ala Asn Val Gly Asp Ile Leu Ser Ala Ala Arg 
            100                 105                 110         


Leu Leu Glu Ile Pro Ala Val Ser His Val Cys Ala Asp Leu Leu Asp 
        115                 120                 125             


Arg Gln Ile Leu Ala Ala Asp Ala Gly Ala Asp Ala Gly Gln Leu Asp 
    130                 135                 140                 


Leu Val Asp Gln Ile Asp Gln Arg Asn Leu Leu Arg Ala Lys Glu Tyr 
145                 150                 155                 160 


Leu Glu Phe Phe Gln Ser Asn Pro Met Asn Ser Leu Pro Pro Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ser Phe Pro Trp Ser Ala Phe Gly Ala Ser Asp 
            180                 185                 190         


Asp Asp Leu Asp Ala Thr Lys Glu Ala Val Ala Ala Ala Val Ala Ala 
        195                 200                 205             


Val Ala Ala Gly Asp Cys Asn Gly Leu Asp Phe Tyr Gly Pro Gly Pro 
    210                 215                 220                 


Pro Ala Glu Arg Pro Pro Thr Gly Asp Gly Asp Glu Gly Asp Ser Asn 
225                 230                 235                 240 


Pro Gly Leu Trp Pro Glu Arg Asp Glu Asp Ala Pro Thr Gly Gly Leu 
                245                 250                 255     


Phe Pro Pro Pro Val Ala Pro Pro Ala Ala Thr Gln Asn Gly His Tyr 
            260                 265                 270         


Gly Arg Gly Gly Glu Glu Glu Ala Ala Ser Leu Ser Glu Ala Ala Pro 
        275                 280                 285             


Glu Pro Gly Asp Ser Pro Gly Phe Leu Ser Gly Ala Ala Glu Gly Glu 
    290                 295                 300                 


Asp Gly Asp Gly Pro Asp Val Asp Gly Leu Ala Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Gln Gln Met Met Ser Ser Val Gly Arg Ala Gly Ala Ala Ala Gly Asp 
                325                 330                 335     


Ser Asp Glu Glu Ser Arg Ala Asp Asp Lys Gly Val Met Asp Tyr Tyr 
            340                 345                 350         


Leu Lys Tyr Phe Ser Gly Ala His Asp Gly Asp Val Tyr Pro Ala Trp 
        355                 360                 365             


Ser Gln Lys Val Glu Lys Lys Ile Arg Ala Lys Ala Phe Gln Lys Cys 
    370                 375                 380                 


Pro Ile Cys Glu Lys Val Ile Gln Gly Ala Gly Lys Leu Pro Arg His 
385                 390                 395                 400 


Ile Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Ile Cys Lys 
                405                 410                 415     


Val Arg Phe Thr Arg Gln Asp Lys Leu Lys Val His Met Arg Lys His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Leu Cys Gln Gln Cys Gly Ala Ala Phe Ala 
        435                 440                 445             


His Asn Tyr Asp Leu Lys Asn His Met Arg Val His Thr Gly Leu Arg 
    450                 455                 460                 


Pro Tyr Gln Cys Asp Ser Cys Cys Lys Thr Phe Val Arg Ser Asp His 
465                 470                 475                 480 


Leu His Arg His Leu Lys Lys Asp Gly Cys Asn Gly Val Pro Ser Arg 
                485                 490                 495     


Arg Gly Arg Lys Pro Arg Val Arg Gly Gly Ala Pro Asp Pro Ser Pro 
            500                 505                 510         


Gly Ala Thr Ala Thr Pro Gly Ala Pro Ala Gln Pro Ser Ser Pro Asp 
        515                 520                 525             


Ala Arg Arg Asn Gly Gln Glu Lys His Phe Lys Asp Glu Asp Glu Asp 
    530                 535                 540                 


Glu Asp Val Ala Ser Pro Asp Gly Leu Gly Arg Leu Asn Val Ala Gly 
545                 550                 555                 560 


Ala Gly Gly Gly Gly Asp Ser Gly Gly Gly Pro Gly Ala Ala Thr Asp 
                565                 570                 575     


Gly Asn Phe Thr Ala Gly Leu Ala 
            580                 


<210> 6
<211> 2451
<212> DNA
<213> Homo sapiens

<400> 6
cgtgctttcc acgacggtga cacgcttccc tggattggcc agactgcctt ccgggtcact       60

gccatggagg agccgcagtc agatcctagc gtcgagcccc ctctgagtca ggaaacattt      120

tcagacctat ggaaactact tcctgaaaac aacgttctgt cccccttgcc gtcccaagca      180

atggatgatt tgatgctgtc cccggacgat attgaacaat ggttcactga agacccaggt      240

ccagatgaag ctcccagaat gccagaggct gctccccgcg tggcccctgc accagcagct      300

cctacaccgg cggcccctgc accagccccc tcctggcccc tgtcatcttc tgtcccttcc      360

cagaaaacct accagggcag ctacggtttc cgtctgggct tcttgcattc tgggacagcc      420

aagtctgtga cttgcacgta ctcccctgcc ctcaacaaga tgttttgcca actggccaag      480

acctgccctg tgcagctgtg ggttgattcc acacccccgc ccggcacccg cgtccgcgcc      540

atggccatct acaagcagtc acagcacatg acggaggttg tgaggcgctg cccccaccat      600

gagcgctgct cagatagcga tggtctggcc cctcctcagc atcttatccg agtggaagga      660

aatttgcgtg tggagtattt ggatgacaga aacacttttc gacatagtgt ggtggtgccc      720

tatgagccgc ctgaggttgg ctctgactgt accaccatcc actacaacta catgtgtaac      780

agttcctgca tgggcggcat gaaccggagg cccatcctca ccatcatcac actggaagac      840

tccagtggta atctactggg acggaacagc tttgaggtgc atgtttgtgc ctgtcctggg      900

agagaccggc gcacagagga agagaatctc cgcaagaaag gggagcctca ccacgagctg      960

cccccaggga gcactaagcg agcactgtcc aacaacacca gctcctctcc ccagccaaag     1020

aagaaaccac tggatggaga atatttcacc cttcagatcc gtgggcgtga gcgcttcgag     1080

atgttccgag agctgaatga ggccttggaa ctcaaggatg cccaggctgg gaaggagcca     1140

ggggggagca gggctcactc cagccacctg aagtccaaaa agggtcagtc tacctcccgc     1200

cataaaaaac tcatgttcaa gacagaaggg cctgactcag actgacattc tccacttctt     1260

gttccccact gacagcctcc cacccccatc tctccctccc ctgccatttt gggttttggg     1320

tctttgaacc cttgcttgca ataggtgtgc gtcagaagca cccaggactt ccatttgctt     1380

tgtcccgggg ctccactgaa caagttggcc tgcactggtg ttttgttgtg gggaggagga     1440

tggggagtag gacataccag cttagatttt aaggttttta ctgtgaggga tgtttgggag     1500

atgtaagaaa tgttcttgca gttaagggtt agtttacaat cagccacatt ctaggtaggg     1560

gcccacttca ccgtactaac cagggaagct gtccctcact gttgaatttt ctctaacttc     1620

aaggcccata tctgtgaaat gctggcattt gcacctacct cacagagtgc attgtgaggg     1680

ttaatgaaat aatgtacatc tggccttgaa accacctttt attacatggg gtctagaact     1740

tgaccccctt gagggtgctt gttccctctc cctgttggtc ggtgggttgg tagtttctac     1800

agttgggcag ctggttaggt agagggagtt gtcaagtctc tgctggccca gccaaaccct     1860

gtctgacaac ctcttggtga accttagtac ctaaaaggaa atctcacccc atcccacacc     1920

ctggaggatt tcatctcttg tatatgatga tctggatcca ccaagacttg ttttatgctc     1980

agggtcaatt tcttttttct tttttttttt ttttttcttt ttctttgaga ctgggtctcg     2040

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     2100

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     2160

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2220

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2280

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2340

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2400

atctcttatt ttacaataaa actttgctgc caaaaaaaaa aaaaaaaaaa a              2451


<210> 7
<211> 393
<212> PRT
<213> Homo sapiens

<400> 7
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Arg Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


His Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Ser Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 8
<211> 2251
<212> DNA
<213> Homo sapiens

<400> 8
gccaactggc tcacgcctcc ccttcagctt ctcttcacgc actccaagat ctaaaccgag       60

aatcgaaact aagctggggt ccatggagcc tgcacccgcc cgatctccga ggccccagca      120

ggaccccgcc cggccccagg agcccaccat gcctcccccc gagaccccct ctgaaggccg      180

ccagcccagc cccagcccca gccctacaga gcgagccccc gcttcggagg aggagttcca      240

gtttctgcgc tgccagcaat gccaggcgga agccaagtgc ccgaagctgc tgccttgtct      300

gcacacgctg tgctcaggat gcctggaggc gtcgggcatg cagtgcccca tctgccaggc      360

gccctggccc ctaggtgcag acacacccgc cctggataac gtctttttcg agagtctgca      420

gcggcgcctg tcggtgtacc ggcagattgt ggatgcgcag gctgtgtgca cccgctgcaa      480

agagtcggcc gacttctggt gctttgagtg cgagcagctc ctctgcgcca agtgcttcga      540

ggcacaccag tggttcctca agcacgaggc ccggccccta gcagagctgc gcaaccagtc      600

ggtgcgtgag ttcctggacg gcacccgcaa gaccaacaac atcttctgct ccaaccccaa      660

ccaccgcacc cctacgctga ccagcatcta ctgccgagga tgttccaagc cgctgtgctg      720

ctcgtgcgcg ctccttgaca gcagccacag tgagctcaag tgcgacatca gcgcagagat      780

ccagcagcga caggaggagc tggacgccat gacgcaggcg ctgcaggagc aggatagtgc      840

ctttggcgcg gttcacgcgc agatgcacgc ggccgtcggc cagctgggcc gcgcgcgtgc      900

cgagaccgag gagctgatcc gcgagcgcgt gcgccaggtg gtagctcacg tgcgggctca      960

ggagcgcgag ctgctggagg ctgtggacgc gcggtaccag cgcgactacg aggagatggc     1020

cagtcggctg ggccgcctgg atgctgtgct gcagcgcatc cgcacgggca gcgcgctggt     1080

gcagaggatg aagtgctacg cctcggacca ggaggtgctg gacatgcacg gtttcctgcg     1140

ccaggcgctc tgccgcctgc gccaggagga gccccagagc ctgcaagctg ccgtgcgcac     1200

cgatggcttc gacgagttca aggtgcgcct gcaggacctc agctcttgca tcacccaggg     1260

gaaagatgca gctgtatcca agaaagccag cccagaggct gccagcactc ccagggaccc     1320

tattgacgtt gacctgcccg aggaggcaga gagagtgaag gcccaggttc aggccctggg     1380

gctggctgaa gcccagccta tggctgtggt acagtcagtg cccggggcac accccgtgcc     1440

agtgtacgcc ttctccatca aaggcccttc ctatggagag gatgtctcca atacaacgac     1500

agcccagaag aggaagtgca gccagaccca gtgccccagg aaggtcatca agatggagtc     1560

tgaggagggg aaggaggcaa ggttggctcg gagctccccg gagcagccca ggcccagcac     1620

ctccaaggca gtctcaccac cccacctgga tggaccgcct agccccagga gccccgtcat     1680

aggaagtgag gtcttcctgc ccaacagcaa ccacgtggcc agtggcgccg gggaggcaga     1740

ggaacgcgtt gtggtgatca gcagctcgga agactcagat gccgaaaact cggtctcttc     1800

cagccctcag tctgaggttc tgtattggaa agtgcatgga gcccatggag accgccgagc     1860

cacagtcctc gccagcccac tcctcgccag cccactcctc gccagcccac tcctcgccag     1920

tccagtctct gctgagagca caaggagcct ccagcctgcc ctgtggcaca taccaccccc     1980

cagcttggcc tccccaccag cccgctgagc aggctgccac ccccgatgct gagcctcaca     2040

gcgagcctcc tgatcaccag gagcgccctg ccgtccaccg tgggatccgc tacctgttgt     2100

acagagcaca gagagccatc cgccttcgcc atgccctccg cttgcaccct caattgcatc     2160

gggcccctat tcggacttgg tctccccatg tggtccaagc cagcactcct gccatcacag     2220

ggcccctcaa ccatcctgcc aatgcccagg a                                    2251


<210> 9
<211> 641
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Pro Ala Pro Ala Arg Ser Pro Arg Pro Gln Gln Asp Pro Ala 
1               5                   10                  15      


Arg Pro Gln Glu Pro Thr Met Pro Pro Pro Glu Thr Pro Ser Glu Gly 
            20                  25                  30          


Arg Gln Pro Ser Pro Ser Pro Ser Pro Thr Glu Arg Ala Pro Ala Ser 
        35                  40                  45              


Glu Glu Glu Phe Gln Phe Leu Arg Cys Gln Gln Cys Gln Ala Glu Ala 
    50                  55                  60                  


Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr Leu Cys Ser Gly Cys 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Met Gln Cys Pro Ile Cys Gln Ala Pro Trp Pro 
                85                  90                  95      


Leu Gly Ala Asp Thr Pro Ala Leu Asp Asn Val Phe Phe Glu Ser Leu 
            100                 105                 110         


Gln Arg Arg Leu Ser Val Tyr Arg Gln Ile Val Asp Ala Gln Ala Val 
        115                 120                 125             


Cys Thr Arg Cys Lys Glu Ser Ala Asp Phe Trp Cys Phe Glu Cys Glu 
    130                 135                 140                 


Gln Leu Leu Cys Ala Lys Cys Phe Glu Ala His Gln Trp Phe Leu Lys 
145                 150                 155                 160 


His Glu Ala Arg Pro Leu Ala Glu Leu Arg Asn Gln Ser Val Arg Glu 
                165                 170                 175     


Phe Leu Asp Gly Thr Arg Lys Thr Asn Asn Ile Phe Cys Ser Asn Pro 
            180                 185                 190         


Asn His Arg Thr Pro Thr Leu Thr Ser Ile Tyr Cys Arg Gly Cys Ser 
        195                 200                 205             


Lys Pro Leu Cys Cys Ser Cys Ala Leu Leu Asp Ser Ser His Ser Glu 
    210                 215                 220                 


Leu Lys Cys Asp Ile Ser Ala Glu Ile Gln Gln Arg Gln Glu Glu Leu 
225                 230                 235                 240 


Asp Ala Met Thr Gln Ala Leu Gln Glu Gln Asp Ser Ala Phe Gly Ala 
                245                 250                 255     


Val His Ala Gln Met His Ala Ala Val Gly Gln Leu Gly Arg Ala Arg 
            260                 265                 270         


Ala Glu Thr Glu Glu Leu Ile Arg Glu Arg Val Arg Gln Val Val Ala 
        275                 280                 285             


His Val Arg Ala Gln Glu Arg Glu Leu Leu Glu Ala Val Asp Ala Arg 
    290                 295                 300                 


Tyr Gln Arg Asp Tyr Glu Glu Met Ala Ser Arg Leu Gly Arg Leu Asp 
305                 310                 315                 320 


Ala Val Leu Gln Arg Ile Arg Thr Gly Ser Ala Leu Val Gln Arg Met 
                325                 330                 335     


Lys Cys Tyr Ala Ser Asp Gln Glu Val Leu Asp Met His Gly Phe Leu 
            340                 345                 350         


Arg Gln Ala Leu Cys Arg Leu Arg Gln Glu Glu Pro Gln Ser Leu Gln 
        355                 360                 365             


Ala Ala Val Arg Thr Asp Gly Phe Asp Glu Phe Lys Val Arg Leu Gln 
    370                 375                 380                 


Asp Leu Ser Ser Cys Ile Thr Gln Gly Lys Asp Ala Ala Val Ser Lys 
385                 390                 395                 400 


Lys Ala Ser Pro Glu Ala Ala Ser Thr Pro Arg Asp Pro Ile Asp Val 
                405                 410                 415     


Asp Leu Pro Glu Glu Ala Glu Arg Val Lys Ala Gln Val Gln Ala Leu 
            420                 425                 430         


Gly Leu Ala Glu Ala Gln Pro Met Ala Val Val Gln Ser Val Pro Gly 
        435                 440                 445             


Ala His Pro Val Pro Val Tyr Ala Phe Ser Ile Lys Gly Pro Ser Tyr 
    450                 455                 460                 


Gly Glu Asp Val Ser Asn Thr Thr Thr Ala Gln Lys Arg Lys Cys Ser 
465                 470                 475                 480 


Gln Thr Gln Cys Pro Arg Lys Val Ile Lys Met Glu Ser Glu Glu Gly 
                485                 490                 495     


Lys Glu Ala Arg Leu Ala Arg Ser Ser Pro Glu Gln Pro Arg Pro Ser 
            500                 505                 510         


Thr Ser Lys Ala Val Ser Pro Pro His Leu Asp Gly Pro Pro Ser Pro 
        515                 520                 525             


Arg Ser Pro Val Ile Gly Ser Glu Val Phe Leu Pro Asn Ser Asn His 
    530                 535                 540                 


Val Ala Ser Gly Ala Gly Glu Ala Glu Glu Arg Val Val Val Ile Ser 
545                 550                 555                 560 


Ser Ser Glu Asp Ser Asp Ala Glu Asn Ser Val Ser Ser Ser Pro Gln 
                565                 570                 575     


Ser Glu Val Leu Tyr Trp Lys Val His Gly Ala His Gly Asp Arg Arg 
            580                 585                 590         


Ala Thr Val Leu Ala Ser Pro Leu Leu Ala Ser Pro Leu Leu Ala Ser 
        595                 600                 605             


Pro Leu Leu Ala Ser Pro Val Ser Ala Glu Ser Thr Arg Ser Leu Gln 
    610                 615                 620                 


Pro Ala Leu Trp His Ile Pro Pro Pro Ser Leu Ala Ser Pro Pro Ala 
625                 630                 635                 640 


Arg 
    


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
acaacgtccc tctcggtaga                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
ccaagttatc agtcaccttc                                                   20


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gctccctcat gggcaaactc act                                               23


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gggcagtgtg gaaagaagag                                                   20


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
cataacaggt gaggtgacgc tg                                                22


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
tggctggtct acctggctcc tct                                               23


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cgtcgacaac ggctccggca                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
caggatgttg acagcaagag                                                   20


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ggcctgctgt tcacagttg                                                    19


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ctgcaaccaa gtcttctcag                                                   20


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
cttctgtgct ccagggttct c                                                 21


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gctgctttgc ctacctctcc                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gctttcagca tccaagtgtg                                                   20


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gcctctcgta catacagacg c                                                 21


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gtgtgtggct tttcaaacct ca                                                22


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
actgcaccca aaccgaagtc                                                   20


<210> 26
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ccaaccacca ggctacagg                                                    19


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
gattttgaga ccatccagag c                                                 21


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
tgcattccgc ttagctttct                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cacttcataa cctccagatc                                                   20


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ggagttcgag gaaccctagt g                                                 21


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ccaagtgctg ccgtcatttt c                                                 21


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gtaaaccagt cagcctgag                                                    19


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ggaaatgaag ccaaagtacc                                                   20


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
caaggctggt ccatgctcc                                                    19


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
ggactgcttt gagcgcaaag                                                   20


<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
aggtggctct tggaaggtg                                                    19


<210> 37
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gaaatgccac cttttgacag tg                                                22


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
gcacagttgg caacctttat g                                                 21


<210> 39
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
aaatcaccat gccctctaca ag                                                22


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
tttttccagc agaccagctt                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
ttctgtgctg tcccagtgag                                                   20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
atcgatttct cccctgtgaa                                                   20


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
gtcggcttct tctccaatca g                                                 21


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
tgggcctcgt cacccacata gg                                                22


<210> 45
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
catctttctg taacactgg                                                    19


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ctgctggtga tcctcttgta g                                                 21


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
gccggtttct cttagtcagg                                                   20


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
ctgtctgcct cttttggtca g                                                 21


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
tcgagtgaca aacacgactg c                                                 21


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
gactactggt gatccttctg                                                   20


<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
ccagttctgc tttggatcag c                                                 21


<210> 52
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
tgcatgaact cactctttcc ag                                                22


<210> 53
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
tggggacacc ttttagcatc tt                                                22


<210> 54
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
gcgtcacact caagctctg                                                    19


<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
ctcttcagta tcttcttgat g                                                 21


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
cagaaggagg tctgtctgga                                                   20


<210> 57
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
cacagtgaac tcctggcctg tac                                               23


<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gggatttgta gtggatcgtg c                                                 21


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
ggctcgcagg gatgatttca a                                                 21


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gctttctcca ggtactcttg                                                   20


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
gatgaagcgt ttggtgctct g                                                 21


<210> 62
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
tgctatcact tcctttctgt tgc                                               23


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
ctgagtgctc tgactatgtg                                                   20


<210> 64
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
ggtgacatcg tttgagaaat tgc                                               23


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
tggatgctct catcaggaca g                                                 21


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
tgattgtcct ggtttgtgtc c                                                 21


<210> 67
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
cccactttta tcaccatcgc aa                                                22


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
agagattatc ggagcgcctt                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
tgaagaaaac cccttgtgct                                                   20


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
tgtcaaattc attcatggcc t                                                 21


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 71
catcacgaca ggaatgacca g                                                 21


<210> 72
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 72
tggcacccag cacaatgaa                                                    19


<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 73
ctgttggtgc tgctgctgct g                                                 21


<210> 74
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 74
tgctgccact aatgctgatg t                                                 21


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 75
gacctgtcac tgtcttgtac                                                   20


<210> 76
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 76
ctaagtcata gtccgcctag a                                                 21


<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 77
cgaacacttg cagattactg                                                   20


<210> 78
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 78
ctcaggaacc aatctttgca ct                                                22


<210> 79
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 79
cttcctcttg gagaagatca g                                                 21


