                         SEQUENCE LISTING

<110>  RetroSense Therapeutics
 
<120>  IDENTIFICATION OF MUTATIONS IN CHANNELOPSIN VARIANTS HAVING 
       IMPROVED LIGHT SENSITIVITY AND METHODS OF USE THEREOF

<130>  RTRO-707/001WO

<150>  US 62/380,871
<151>  2016-08-29

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1
atgctgggaa acggcagcgc cattgtgcct atcgaccagt gcttttgcct ggcttggacc       60

gacagcctgg gaagcgatac agagcagctg gtggccaaca tcctccagtg gttcgccttc      120

ggcttcagca tcctgatcct gatgttctac gcctaccaga cttggagagc cacttgcggt      180

tgggaggagg tctacgtctg ttgcgtcgag ctgaccaagg tcatcatcga gttcttccac      240

gagttcgacg accccagcat gctgtacctg gctaacggac accgagtcca gtggctgaga      300

tacgcagagt ggctgctgac ttgtcccgtc atcctgatcc acctgagcaa cctgacaggc      360

ctgaaggacg actacagcaa gcggaccatg aggctgctgg tgtcagacgt gggaaccatc      420

gtgtggggag ctacaagcgc catgagcaca ggctacgtca aggtcatctt cttcgtgctg      480

ggttgcatct acggcgccaa caccttcttc cacgccgcca aggtgtatat cgagagctac      540

cacgtggtgc caaagggcag acctagaacc gtcgtgcgga tcatggcttg gctgttcttc      600

ctgtcttggg gcatgttccc cgtgctgttc gtcgtgggac cagaaggatt cgacgccatc      660

agcgtgtacg gctctaccat tggccacacc atcatcgacc tcatgagcaa gaattgttgg      720

ggcctgctgg gacactatct gagagtgctg atccaccagc acatcatcat ctacggcgac      780

atccgcaaga agaccaagat caacgtggcc ggcgaggaga tggaagtgga gaccatggtg      840

gaccaggagg acgaggagac agtg                                             864


<210>  2
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  3
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic sequence

<400>  3

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Cys 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  4
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Ser Ile Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  5
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  6
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Ala Ala Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  7
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Thr Leu Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  8
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly His Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Cys 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  9
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly Glu Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Cys 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Lys Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


<210>  10
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Met Leu Gly Asn Gly Ser Ala Ile Val Pro Ile Asp Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Thr Asp Ser Leu Gly Ser Asp Thr Glu Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Phe Ala Phe Gly Phe Ser Ile Leu Ile Leu Met 
        35                  40                  45              


Phe Tyr Ala Tyr Gln Thr Trp Arg Ala Thr Cys Gly Trp Glu Glu Val 
    50                  55                  60                  


Tyr Val Cys Cys Val Glu Leu Thr Lys Val Ile Ile Glu Phe Phe His 
65                  70                  75                  80  


Glu Phe Asp Asp Pro Ser Met Leu Tyr Leu Ala Asn Gly Glu Arg Val 
                85                  90                  95      


Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Cys 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Arg Leu Leu Val Ser Asp Val Gly Thr Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Ser Thr Gly Tyr Val Lys Val Ile Phe Phe Val Leu 
145                 150                 155                 160 


Gly Cys Ile Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ser Tyr His Val Val Pro Lys Gly Arg Pro Arg Thr Val Val 
            180                 185                 190         


Arg Ile Met Ala Trp Leu Phe Phe Leu Ser Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Val Val Gly Pro Glu Gly Phe Asp Ala Ile Ser Val Tyr Gly 
    210                 215                 220                 


Ser Thr Ile Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp 
225                 230                 235                 240 


Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His Gln His Ile Ile 
                245                 250                 255     


Ile Tyr Gly Asp Ile Arg Lys Thr Thr Lys Ile Asn Val Ala Gly Glu 
            260                 265                 270         


Glu Met Glu Val Glu Thr Met Val Asp Gln Glu Asp Glu Glu Thr Val 
        275                 280                 285             


