                               SEQUENCE LISTING

<110> BETH ISRAEL DEACONESS MEDICAL CENTER
 
<120> COMPOSITIONS AND METHODS FOR TREATING CANCER

<130> 167688-020201/PCT

<140> PCT/US2017/049143
<141> 2017-08-29

<150> 62/381,346
<151> 2016-08-30

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 403
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210> 2
<211> 8718
<212> DNA
<213> Homo sapiens

<400> 2
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa     5580

ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag     5640

ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa     5700

aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact     5760

tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta     5820

gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt     5880

gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta     5940

ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc     6000

atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg     6060

ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt     6120

aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca     6180

gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa     6240

aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat     6300

cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga     6360

agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc     6420

tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag     6480

aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag     6540

acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc     6600

agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta     6660

gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa     6720

ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag     6780

atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa     6840

tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt     6900

ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac     6960

aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa     7020

tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc     7080

atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt     7140

aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa     7200

atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt     7260

tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca     7320

gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg     7380

tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata     7440

gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga     7500

attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc     7560

cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa     7620

ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa     7680

atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct     7740

gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata     7800

gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca     7860

atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac     7920

tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt     7980

ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt     8040

gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc     8100

tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg     8160

gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc     8220

ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta     8280

ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg     8340

tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt     8400

aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa     8460

tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt     8520

agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt     8580

tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa     8640

atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact     8700

aaaaaaaaaa aaaaaaaa                                                   8718


<210> 3
<211> 1365
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Phe Ser Ile Lys Gln Ser Pro Leu Ser Val Gln Ser Val Val 
1               5                   10                  15      


Lys Cys Ile Lys Met Lys Gln Ala Pro Glu Ile Leu Gly Ser Ala Asn 
            20                  25                  30          


Gly Lys Thr Pro Ser Cys Glu Val Asn Arg Glu Cys Ser Val Phe Leu 
        35                  40                  45              


Ser Lys Ala Gln Leu Ser Ser Ser Leu Gln Glu Gly Val Met Gln Lys 
    50                  55                  60                  


Phe Asn Gly His Asp Ala Leu Pro Phe Ile Pro Ala Asp Lys Leu Lys 
65                  70                  75                  80  


Asp Leu Thr Ser Arg Val Phe Asn Gly Glu Pro Gly Ala His Asp Ala 
                85                  90                  95      


Lys Leu Arg Phe Glu Ser Gln Glu Met Lys Gly Ile Gly Thr Pro Pro 
            100                 105                 110         


Asn Thr Thr Pro Ile Lys Asn Gly Ser Pro Glu Ile Lys Leu Lys Ile 
        115                 120                 125             


Thr Lys Thr Tyr Met Asn Gly Lys Pro Leu Phe Glu Ser Ser Ile Cys 
    130                 135                 140                 


Gly Asp Ser Ala Ala Asp Val Ser Gln Ser Glu Glu Asn Gly Gln Lys 
145                 150                 155                 160 


Pro Glu Asn Lys Ala Arg Arg Asn Arg Lys Arg Ser Ile Lys Tyr Asp 
                165                 170                 175     


Ser Leu Leu Glu Gln Gly Leu Val Glu Ala Ala Leu Val Ser Lys Ile 
            180                 185                 190         


Ser Ser Pro Ser Asp Lys Lys Ile Pro Ala Lys Lys Glu Ser Cys Pro 
        195                 200                 205             


Asn Thr Gly Arg Asp Lys Asp His Leu Leu Lys Tyr Asn Val Gly Asp 
    210                 215                 220                 


Leu Val Trp Ser Lys Val Ser Gly Tyr Pro Trp Trp Pro Cys Met Val 
225                 230                 235                 240 


Ser Ala Asp Pro Leu Leu His Ser Tyr Thr Lys Leu Lys Gly Gln Lys 
                245                 250                 255     


Lys Ser Ala Arg Gln Tyr His Val Gln Phe Phe Gly Asp Ala Pro Glu 
            260                 265                 270         


Arg Ala Trp Ile Phe Glu Lys Ser Leu Val Ala Phe Glu Gly Glu Gly 
        275                 280                 285             


Gln Phe Glu Lys Leu Cys Gln Glu Ser Ala Lys Gln Ala Pro Thr Lys 
    290                 295                 300                 


Ala Glu Lys Ile Lys Leu Leu Lys Pro Ile Ser Gly Lys Leu Arg Ala 
305                 310                 315                 320 


Gln Trp Glu Met Gly Ile Val Gln Ala Glu Glu Ala Ala Ser Met Ser 
                325                 330                 335     


Val Glu Glu Arg Lys Ala Lys Phe Thr Phe Leu Tyr Val Gly Asp Gln 
            340                 345                 350         


Leu His Leu Asn Pro Gln Val Ala Lys Glu Ala Gly Ile Ala Ala Glu 
        355                 360                 365             


Ser Leu Gly Glu Met Ala Glu Ser Ser Gly Val Ser Glu Glu Ala Ala 
    370                 375                 380                 


Glu Asn Pro Lys Ser Val Arg Glu Glu Cys Ile Pro Met Lys Arg Arg 
385                 390                 395                 400 


Arg Arg Ala Lys Leu Cys Ser Ser Ala Glu Thr Leu Glu Ser His Pro 
                405                 410                 415     


Asp Ile Gly Lys Ser Thr Pro Gln Lys Thr Ala Glu Ala Asp Pro Arg 
            420                 425                 430         


Arg Gly Val Gly Ser Pro Pro Gly Arg Lys Lys Thr Thr Val Ser Met 
        435                 440                 445             


Pro Arg Ser Arg Lys Gly Asp Ala Ala Ser Gln Phe Leu Val Phe Cys 
    450                 455                 460                 


Gln Lys His Arg Asp Glu Val Val Ala Glu His Pro Asp Ala Ser Gly 
465                 470                 475                 480 


Glu Glu Ile Glu Glu Leu Leu Arg Ser Gln Trp Ser Leu Leu Ser Glu 
                485                 490                 495     


Lys Gln Arg Ala Arg Tyr Asn Thr Lys Phe Ala Leu Val Ala Pro Val 
            500                 505                 510         


Gln Ala Glu Glu Asp Ser Gly Asn Val Asn Gly Lys Lys Arg Asn His 
        515                 520                 525             


Thr Lys Arg Ile Gln Asp Pro Thr Glu Asp Ala Glu Ala Glu Asp Thr 
    530                 535                 540                 


Pro Arg Lys Arg Leu Arg Thr Asp Lys His Ser Leu Arg Lys Arg Asp 
545                 550                 555                 560 


Thr Ile Thr Asp Lys Thr Ala Arg Thr Ser Ser Tyr Lys Ala Met Glu 
                565                 570                 575     


Ala Ala Ser Ser Leu Lys Ser Gln Ala Ala Thr Lys Asn Leu Ser Asp 
            580                 585                 590         


Ala Cys Lys Pro Leu Lys Lys Arg Asn Arg Ala Ser Thr Ala Ala Ser 
        595                 600                 605             


Ser Ala Leu Gly Phe Ser Lys Ser Ser Ser Pro Ser Ala Ser Leu Thr 
    610                 615                 620                 


Glu Asn Glu Val Ser Asp Ser Pro Gly Asp Glu Pro Ser Glu Ser Pro 
625                 630                 635                 640 


Tyr Glu Ser Ala Asp Glu Thr Gln Thr Glu Val Ser Val Ser Ser Lys 
                645                 650                 655     


Lys Ser Glu Arg Gly Val Thr Ala Lys Lys Glu Tyr Val Cys Gln Leu 
            660                 665                 670         


Cys Glu Lys Pro Gly Ser Leu Leu Leu Cys Glu Gly Pro Cys Cys Gly 
        675                 680                 685             


Ala Phe His Leu Ala Cys Leu Gly Leu Ser Arg Arg Pro Glu Gly Arg 
    690                 695                 700                 


Phe Thr Cys Ser Glu Cys Ala Ser Gly Ile His Ser Cys Phe Val Cys 
705                 710                 715                 720 


Lys Glu Ser Lys Thr Asp Val Lys Arg Cys Val Val Thr Gln Cys Gly 
                725                 730                 735     


Lys Phe Tyr His Glu Ala Cys Val Lys Lys Tyr Pro Leu Thr Val Phe 
            740                 745                 750         


Glu Ser Arg Gly Phe Arg Cys Pro Leu His Ser Cys Val Ser Cys His 
        755                 760                 765             


Ala Ser Asn Pro Ser Asn Pro Arg Pro Ser Lys Gly Lys Met Met Arg 
    770                 775                 780                 


Cys Val Arg Cys Pro Val Ala Tyr His Ser Gly Asp Ala Cys Leu Ala 
785                 790                 795                 800 


Ala Gly Cys Ser Val Ile Ala Ser Asn Ser Ile Ile Cys Thr Ala His 
                805                 810                 815     


Phe Thr Ala Arg Lys Gly Lys Arg His His Ala His Val Asn Val Ser 
            820                 825                 830         


Trp Cys Phe Val Cys Ser Lys Gly Gly Ser Leu Leu Cys Cys Glu Ser 
        835                 840                 845             


Cys Pro Ala Ala Phe His Pro Asp Cys Leu Asn Ile Glu Met Pro Asp 
    850                 855                 860                 


Gly Ser Trp Phe Cys Asn Asp Cys Arg Ala Gly Lys Lys Leu His Phe 
865                 870                 875                 880 


Gln Asp Ile Ile Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala 
                885                 890                 895     


Glu Val Cys His Pro Lys Asn Val Pro Pro Asn Ile Gln Lys Met Lys 
            900                 905                 910         


His Glu Ile Gly Glu Phe Pro Val Phe Phe Phe Gly Ser Lys Asp Tyr 
        915                 920                 925             


Tyr Trp Thr His Gln Ala Arg Val Phe Pro Tyr Met Glu Gly Asp Arg 
    930                 935                 940                 


Gly Ser Arg Tyr Gln Gly Val Arg Gly Ile Gly Arg Val Phe Lys Asn 
945                 950                 955                 960 


Ala Leu Gln Glu Ala Glu Ala Arg Phe Arg Glu Ile Lys Leu Gln Arg 
                965                 970                 975     


Glu Ala Arg Glu Thr Gln Glu Ser Glu Arg Lys Pro Pro Pro Tyr Lys 
            980                 985                 990         


His Ile Lys Val Asn Lys Pro Tyr  Gly Lys Val Gln Ile  Tyr Thr Ala 
        995                 1000                 1005             


Asp Ile  Ser Glu Ile Pro Lys  Cys Asn Cys Lys Pro  Thr Asp Glu 
    1010                 1015                 1020             


Asn Pro  Cys Gly Phe Asp Ser  Glu Cys Leu Asn Arg  Met Leu Met 
    1025                 1030                 1035             


Phe Glu  Cys His Pro Gln Val  Cys Pro Ala Gly Glu  Phe Cys Gln 
    1040                 1045                 1050             


Asn Gln  Cys Phe Thr Lys Arg  Gln Tyr Pro Glu Thr  Lys Ile Ile 
    1055                 1060                 1065             


Lys Thr  Asp Gly Lys Gly Trp  Gly Leu Val Ala Lys  Arg Asp Ile 
    1070                 1075                 1080             


Arg Lys  Gly Glu Phe Val Asn  Glu Tyr Val Gly Glu  Leu Ile Asp 
    1085                 1090                 1095             


Glu Glu  Glu Cys Met Ala Arg  Ile Lys His Ala His  Glu Asn Asp 
    1100                 1105                 1110             


Ile Thr  His Phe Tyr Met Leu  Thr Ile Asp Lys Asp  Arg Ile Ile 
    1115                 1120                 1125             


Asp Ala  Gly Pro Lys Gly Asn  Tyr Ser Arg Phe Met  Asn His Ser 
    1130                 1135                 1140             


Cys Gln  Pro Asn Cys Glu Thr  Leu Lys Trp Thr Val  Asn Gly Asp 
    1145                 1150                 1155             


Thr Arg  Val Gly Leu Phe Ala  Val Cys Asp Ile Pro  Ala Gly Thr 
    1160                 1165                 1170             


Glu Leu  Thr Phe Asn Tyr Asn  Leu Asp Cys Leu Gly  Asn Glu Lys 
    1175                 1180                 1185             


Thr Val  Cys Arg Cys Gly Ala  Ser Asn Cys Ser Gly  Phe Leu Gly 
    1190                 1195                 1200             


Asp Arg  Pro Lys Thr Ser Thr  Thr Leu Ser Ser Glu  Glu Lys Gly 
    1205                 1210                 1215             


Lys Lys  Thr Lys Lys Lys Thr  Arg Arg Arg Arg Ala  Lys Gly Glu 
    1220                 1225                 1230             


Gly Lys  Arg Gln Ser Glu Asp  Glu Cys Phe Arg Cys  Gly Asp Gly 
    1235                 1240                 1245             


Gly Gln  Leu Val Leu Cys Asp  Arg Lys Phe Cys Thr  Lys Ala Tyr 
    1250                 1255                 1260             


His Leu  Ser Cys Leu Gly Leu  Gly Lys Arg Pro Phe  Gly Lys Trp 
    1265                 1270                 1275             


Glu Cys  Pro Trp His His Cys  Asp Val Cys Gly Lys  Pro Ser Thr 
    1280                 1285                 1290             


Ser Phe  Cys His Leu Cys Pro  Asn Ser Phe Cys Lys  Glu His Gln 
    1295                 1300                 1305             


Asp Gly  Thr Ala Phe Ser Cys  Thr Pro Asp Gly Arg  Ser Tyr Cys 
    1310                 1315                 1320             


Cys Glu  His Asp Leu Gly Ala  Ala Ser Val Arg Ser  Thr Lys Thr 
    1325                 1330                 1335             


Glu Lys  Pro Pro Pro Glu Pro  Gly Lys Pro Lys Gly  Lys Arg Arg 
    1340                 1345                 1350             


Arg Arg  Arg Gly Trp Arg Arg  Val Thr Glu Gly Lys  
    1355                 1360                 1365 


<210> 4
<211> 7886
<212> DNA
<213> Homo sapiens

<400> 4
tggtcttgaa ctcctgacct tgtgatccgc tcgcctcagc ctcccaaagt gctgggatta       60

caggcatgag ccaccgtgcc tgtcctagaa ccactggtaa ctcttaactg agacaagatt      120

tcgccatgtt gcccaggctg gtctcgaact tctgagctca agcgatctac ctgcctcgtc      180

ctcccaaagt gttggaattg caggtgtgag ccactgcacc cggcccttgc ctcatgtttg      240

aatgataatt tacctgggca taaaattctg gacacttgtg gtggcacgag ctgtctgctt      300

ttctgtggag actgcgggtt gcagacacca gcagccccct attgctgcac gtcaggtgtc      360

ctccacctca gtactgtgga catctcgggc cgcatagccc tgttgcgcgg gcatcctgtg      420

cgttgcagga gatgcagcag catccatgac cgcaacccat cagagtgttc taagaacgga      480

agcatctggg ctggatggaa tttagcatca agcagagtcc cctttctgtt cagagtgttg      540

taaagtgcat aaagatgaag caggcaccag aaatcctcgg cagtgccaac gggaagactc      600

cgagctgcga ggtgaaccgc gagtgttctg tgttcctcag caaagcccag ctctccagta      660

gcctgcagga gggggtcatg cagaagttta acggccacga cgccctgccc tttattccag      720

ccgacaagct gaaagatctt acttcccggg tgtttaatgg agaacccggc gcacacgatg      780

ccaaactgcg ttttgagtcc caggaaatga aagggattgg gacaccccct aacactaccc      840

ctatcaaaaa tggctctcca gaaattaagc tgaaaatcac caaaacatac atgaatggga      900

agcctctctt tgaatcttcc atttgtggtg acagtgctgc tgatgtgtct cagtcagaag      960

aaaatggaca aaaaccagaa aacaaggcga gaaggaacag gaagaggagc ataaaatatg     1020

actccttgct ggagcagggc cttgtcgaag cagctcttgt gtctaagatc tcaagtcctt     1080

cagataaaaa gattccagct aagaaagagt cttgtccaaa cactggaaga gacaaagacc     1140

acctgttgaa atacaacgtt ggtgatttgg tgtggtccaa agtgtcgggt tacccttggt     1200

ggccttgcat ggtttctgca gatccactcc ttcacagcta taccaaactt aaaggtcaga     1260

aaaagagtgc acgccagtat cacgtacagt tctttggtga cgccccagaa agagcttgga     1320

tatttgagaa gagcctcgta gcttttgaag gagaaggaca gtttgaaaaa ttatgccagg     1380

aaagtgccaa gcaggcaccc acgaaagctg agaaaattaa gctattgaaa ccaatttcag     1440

ggaaattgag ggcccagtgg gaaatgggca ttgttcaagc agaagaagct gcaagcatgt     1500

cagtggagga gcggaaagcc aagttcacct ttctctatgt gggggaccag cttcatctca     1560

accctcaagt agccaaggag gctggcattg ctgcagagtc tttgggagaa atggcagaat     1620

cctcaggagt cagtgaagaa gctgctgaaa accccaagtc tgtgagagaa gagtgcattc     1680

ccatgaagag aaggcggagg gccaaactgt gtagctctgc agagaccctg gagagtcacc     1740

ccgacatagg gaagagtact cctcaaaaga cggcagaggc tgaccccaga agaggagtag     1800

ggtctcctcc tgggaggaag aagaccacag tctccatgcc acgaagcagg aagggagatg     1860

cagcatccca gtttttggtc ttctgtcaaa aacacaggga tgaggtggta gctgagcacc     1920

cagatgcttc aggtgaggag attgaagagc tgctcaggtc acagtggagt ctgctgagtg     1980

agaagcagag agcacgctac aacaccaagt ttgccctggt ggcccctgtc caggctgaag     2040

aagactctgg taatgtaaat gggaaaaaaa gaaaccacac aaagaggata caggacccta     2100

cagaagatgc tgaagctgag gacacaccca ggaaaagact caggacggac aagcacagtc     2160

ttcggaagag agacacaatc actgacaaaa cggccagaac aagctcttac aaggccatgg     2220

aggcagcctc ctcgctcaag agccaggcag caacgaaaaa tctgtctgat gcatgtaaac     2280

cactgaagaa gcgaaatcgg gcttccacgg cagcatcttc agctcttggg tttagcaaaa     2340

gttcatctcc ttctgcatcc ttaactgaga atgaggtctc ggacagcccg ggagacgagc     2400

cctcggagtc cccatacgaa agtgcagacg aaacacaaac tgaagtatct gtctcatcca     2460

aaaagtctga gcgaggagtg actgccaaaa aggagtatgt gtgccagctg tgtgagaagc     2520

cgggcagcct cctgctctgt gaaggaccct gctgcggagc tttccacctc gcctgccttg     2580

ggctttcccg gaggccagaa gggaggttca cctgcagcga gtgtgcctca gggattcact     2640

catgtttcgt gtgtaaagag agcaagacag atgttaagcg ctgtgtggta actcagtgtg     2700

gaaaatttta ccatgaggct tgtgtgaaaa aataccctct gactgtattt gagagccgag     2760

gtttccgctg ccccctccac agctgtgtga gctgccatgc ttccaaccct tcaaacccaa     2820

ggccgtcaaa aggtaaaatg atgcggtgtg tccgctgccc cgttgcctat cacagcgggg     2880

atgcttgtct ggcagcagga tgctcagtga tcgcctccaa cagcatcatc tgcactgccc     2940

acttcactgc tcggaagggg aagcgacacc acgcccacgt caacgtgagc tggtgcttcg     3000

tgtgctccaa aggggggagc cttctgtgct gtgagtcctg cccagcggcc ttccaccctg     3060

actgcctgaa catcgagatg cctgacggca gctggttctg caatgactgc agggctggga     3120

agaagctgca cttccaggat atcatttggg tgaaacttgg gaactacaga tggtggccgg     3180

cagaagtttg ccatcccaaa aatgttcccc caaatattca gaaaatgaag cacgagattg     3240

gagaattccc tgtgtttttc tttgggtcta aagattatta ctggacgcat caggcgcgag     3300

tgttcccgta catggagggg gaccggggca gccgctacca gggggtcaga gggatcggaa     3360

gagtcttcaa aaacgcactg caagaagctg aagctcgttt tcgtgaaatt aagcttcaga     3420

gggaagcccg agaaacacag gagagcgagc gcaagccccc accatacaag cacatcaagg     3480

tgaataagcc ttacgggaaa gtccagatct acacagcgga tatttcagaa atccctaagt     3540

gcaactgcaa gcccacagat gagaatcctt gtggctttga ttcggagtgt ctgaacagga     3600

tgctgatgtt tgagtgccac ccgcaggtgt gtcccgcggg cgagttctgc cagaaccagt     3660

gcttcaccaa gcgccagtac ccagagacca agatcatcaa gacagatggc aaagggtggg     3720

gcctggtcgc caagagggac atcagaaagg gagaatttgt taacgagtac gttggggagc     3780

tgatcgacga ggaggagtgc atggcgagaa tcaagcacgc acacgagaac gacatcaccc     3840

acttctacat gctcactata gacaaggacc gtataataga cgctggcccc aaaggaaact     3900

actctcgatt tatgaatcac agctgccagc ccaactgtga gaccctcaag tggacagtga     3960

atggggacac tcgtgtgggc ctgtttgccg tctgtgacat tcctgcaggg acggagctga     4020

cttttaacta caacctcgat tgtctgggca atgaaaaaac ggtctgccgg tgtggagcct     4080

ccaattgcag tggattcctc ggggatagac caaagacctc gacgaccctt tcatcagagg     4140

aaaagggcaa aaagaccaag aagaaaacga ggcggcgcag agcaaaaggg gaagggaaga     4200

ggcagtcaga ggacgagtgc ttccgctgcg gtgatggcgg gcagctggtg ctgtgtgacc     4260

gcaagttctg caccaaggcc taccacctgt cctgcctggg ccttggcaag cggcccttcg     4320

ggaagtggga atgtccttgg catcattgtg acgtgtgtgg caaaccttcg acttcatttt     4380

gccacctctg ccccaattcg ttctgtaagg agcaccagga cgggacagcc ttcagctgca     4440

ccccggacgg gcggtcctac tgctgtgagc atgacttagg ggcggcatcg gtcagaagca     4500

ccaagactga gaagcccccc ccagagccag ggaagccgaa ggggaagagg cggcggcgga     4560

ggggctggcg gagagtcaca gagggcaaat agcgccaggc ggccgcttgg ccggatccag     4620

gggcggtgca gggcggccgg ccctgcctgc gggagagggc gagcatgaac tggcccggag     4680

gacccagctc gagccgccag gacacagacg tacaggcctc ctcgggaggg agcgcctccc     4740

caccactgag ccatcctcag cagcgtccgc tgcgtctgca ctgatgaccg tctgagccca     4800

gctcagcgtt cctggacaaa cagcctcact cctcagcgtt accgccacac ttgaatttct     4860

ccgaatgtca aggttccctc ccactctatt tttttaggtt aaagttaatt ggcatatgga     4920

atgttttaat ctcctctgaa atgtgtagcg taggcttttc ccaagggtcg ctagaaactc     4980

gtcttcgcgt tgcccccttt ctggctctca gcgccgtcgc cactcgggag aggctgggtg     5040

aggcccgtgt gaggactgac cctggattcc tcgaaactgc cattgtgatc attactctgc     5100

tctttggaaa tggctgtatc atttttttgt actaatgtga attgttcctc agaaacgctt     5160

cttttccatc ctagtgagaa gctggccctg caggtggtgg cagcaatggt gttgtaagat     5220

ttcctcccgt agttttttct cctcatggat ttgaatgaaa tgccaataac acgtccactt     5280

tcaacgtgta gtttacgcgg agcactttcg aggcctggcc gggttgggcc tacttctcac     5340

ctgggcctat cttctgaact cgctaggttc ttatcaacat ttgggggata actttgtata     5400

tttttttcat ttggcttttc tttaccagtt tctgattttt attctcaata tatttttgct     5460

aaacctattt cacaaatcac caccgactga agtgtgtgtt tactgatgcg gccctgagct     5520

ccatggcgaa aggagtgact ttgcagggcg tgagaccgca gtctgcttag agcacaggaa     5580

gtgacaactt agggagcccc gtagggcgct gcaggccccg gggaccccag cacgtgggtc     5640

taaagagaga cggagtctag ctctcctgcc acccagagtg gcttccatct cagcactctg     5700

tgggtctggt gatggaagat gcagtctctg ctgatcacat gtgccctctg ccagggcacc     5760

tactgagagg tgcggtcctg ggggtggagg cctgcctggc aggtgtgcgt gcctcgtacg     5820

tgtgttatgg gcactggtct aggccaggta tgacacccac tctcctgtga gatttcactt     5880

tagtttttaa aaggtccagt tctacagagt gagacctatc tatctgagta ctacatatgt     5940

tttaagactt ggttcttttt ttgagggatc cttgaccctg ggaagtctgg agcaccctga     6000

gaagggggca ccatgtgtgc ctttgcccac gtgtcctgag gggctgcttg tctgggaggg     6060

agggagagaa cattcagcag caggtgcttt tttatggcct tttcttaaaa taacctaagg     6120

gggacacatc catcttgcag agaagtttac agaactcccc ttgaaaactg ctgctgaggc     6180

tcctgttaaa ttttctgtgg catcttttat gccttggtaa aaactgcagt gtctttggac     6240

ctgagagtgg ctactccgtg gttttgtgac ctgtaagcgt ggggttcagg ggtgtgtggc     6300

cctgcagggt cccacgcctc cctgagcact gactggaagt ttcactggct ggtggctgtc     6360

ccttctccca tcagggtccc cagcaaagtt aactacacag aggacccagg ggaaacgagc     6420

tgtgtagcca ctgacttgct cgcgcggccg tggcctctga ggggcactcg ccggttaaga     6480

cagggtggga gtagtgcttt ccagttcaga ctctaacttc tcccaaagtg tcctaagaaa     6540

atactggatc ggctcataga tttatgctcc ttatgatgcc ctaacttgga aggttgttct     6600

agggacaggc cgggcagtgt ccccacacac accttagagt cgaaggcccc agggccccgc     6660

tgtcacttgc ccaaaagatc ccttccggca ggtaagggac taccaatgct tacgtcaaaa     6720

cagcagaatc ggctttgcag tgcactttgg ggagcagata ttaacttatt tttgtgttgg     6780

acagtagtga aatcttgtga tttttaatcg ctttgataat acttccaaat tttatgattt     6840

ttctgaagga aataatgcaa acattttaaa tatgtttctc cccctttcca aaaactgtta     6900

aactaatgag caagtaacac taactttgaa tgtctctaca atacccgttg ataactcagt     6960

ggagccaggc tttggggtag cggccctgag cttgcagggt ttctcgccac tggggctgac     7020

cacgccccca gctgtgaccg tgggtgtggc tggctctcgg ccctgcccag ctttgttctg     7080

aggacgtggt gacttcctga acatcagctt caatcctcca tcattaatgt gaagcaaaac     7140

acaaaaaccg ccccaatccc tcaggattcc ttggcatccg aaaccagcat ctgcacctaa     7200

acccataccc acccgtgtgc gcccacaggg ggatgtgtcc gaatgggcag cttaaaatgt     7260

ggtcacctgt gggggaaact cttcaggcac ctgaagtgag aacccagctg tccgtcctca     7320

ggccggcctt tcttccggcg acacccgtcc atggctggct gggtcccctt cgcagtgttt     7380

gtctgtcttg acatctaaac cccggcgtgt gcagtgccca tcttccagga ctaccttatt     7440

ttccagaatt aaacctgttt tataattcaa gttaatgcaa atgactgtca gttgccaaat     7500

atcttgatcc tatgagtgta gttgatgact gtttgttagt cagtagagta aaatgctgtg     7560

tccacggggt gtcacagcct caccataccc tgttgaggtg tgaaatgccc cgtcagaaat     7620

taaatacaaa cttaaatgtg cctattggtg tctaaacttc atacaatgta aggtcagatt     7680

ccttttagga atactgggtg ctgtcaccag gtttgatagt tagacttaaa aacttgaaat     7740

tcactttttg gggggaggga tatactgaaa tagagagttg agacttgcca gttgggggaa     7800

aatagcattt aaaatggaaa gctgtgtttg gaaaattgtg tatgagtatt tttgtattaa     7860

aaacatttta aaggcttttt tcttaa                                          7886


<210> 5
<211> 2089
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Asp Thr Gln Ala Ile Asp Trp Asp Val Glu Glu Glu Glu Glu 
1               5                   10                  15      


Thr Glu Gln Ser Ser Glu Ser Leu Arg Cys Asn Val Glu Pro Val Gly 
            20                  25                  30          


Arg Leu His Ile Phe Ser Gly Ala His Gly Pro Glu Lys Asp Phe Pro 
        35                  40                  45              


Leu His Leu Gly Lys Asn Val Val Gly Arg Met Pro Asp Cys Ser Val 
    50                  55                  60                  


Ala Leu Pro Phe Pro Ser Ile Ser Lys Gln His Ala Glu Ile Glu Ile 
65                  70                  75                  80  


Leu Ala Trp Asp Lys Ala Pro Ile Leu Arg Asp Cys Gly Ser Leu Asn 
                85                  90                  95      


Gly Thr Gln Ile Leu Arg Pro Pro Lys Val Leu Ser Pro Gly Val Ser 
            100                 105                 110         


His Arg Leu Arg Asp Gln Glu Leu Ile Leu Phe Ala Asp Leu Leu Cys 
        115                 120                 125             


Gln Tyr His Arg Leu Asp Val Ser Leu Pro Phe Val Ser Arg Gly Pro 
    130                 135                 140                 


Leu Thr Val Glu Glu Thr Pro Arg Val Gln Gly Glu Thr Gln Pro Gln 
145                 150                 155                 160 


Arg Leu Leu Leu Ala Glu Asp Ser Glu Glu Glu Val Asp Phe Leu Ser 
                165                 170                 175     


Glu Arg Arg Met Val Lys Lys Ser Arg Thr Thr Ser Ser Ser Val Ile 
            180                 185                 190         


Val Pro Glu Ser Asp Glu Glu Gly His Ser Pro Val Leu Gly Gly Leu 
        195                 200                 205             


Gly Pro Pro Phe Ala Phe Asn Leu Asn Ser Asp Thr Asp Val Glu Glu 
    210                 215                 220                 


Gly Gln Gln Pro Ala Thr Glu Glu Ala Ser Ser Ala Ala Arg Arg Gly 
225                 230                 235                 240 


Ala Thr Val Glu Ala Lys Gln Ser Glu Ala Glu Val Val Thr Glu Ile 
                245                 250                 255     


Gln Leu Glu Lys Asp Gln Pro Leu Val Lys Glu Arg Asp Asn Asp Thr 
            260                 265                 270         


Lys Val Lys Arg Gly Ala Gly Asn Gly Val Val Pro Ala Gly Val Ile 
        275                 280                 285             


Leu Glu Arg Ser Gln Pro Pro Gly Glu Asp Ser Asp Thr Asp Val Asp 
    290                 295                 300                 


Asp Asp Ser Arg Pro Pro Gly Arg Pro Ala Glu Val His Leu Glu Arg 
305                 310                 315                 320 


Ala Gln Pro Phe Gly Phe Ile Asp Ser Asp Thr Asp Ala Glu Glu Glu 
                325                 330                 335     


Arg Ile Pro Ala Thr Pro Val Val Ile Pro Met Lys Lys Arg Lys Ile 
            340                 345                 350         


Phe His Gly Val Gly Thr Arg Gly Pro Gly Ala Pro Gly Leu Ala His 
        355                 360                 365             


Leu Gln Glu Ser Gln Ala Gly Ser Asp Thr Asp Val Glu Glu Gly Lys 
    370                 375                 380                 


Ala Pro Gln Ala Val Pro Leu Glu Lys Ser Gln Ala Ser Met Val Ile 
385                 390                 395                 400 


Asn Ser Asp Thr Asp Asp Glu Glu Glu Val Ser Ala Ala Leu Thr Leu 
                405                 410                 415     


Ala His Leu Lys Glu Ser Gln Pro Ala Ile Trp Asn Arg Asp Ala Glu 
            420                 425                 430         


Glu Asp Met Pro Gln Arg Val Val Leu Leu Gln Arg Ser Gln Thr Thr 
        435                 440                 445             


Thr Glu Arg Asp Ser Asp Thr Asp Val Glu Glu Glu Glu Leu Pro Val 
    450                 455                 460                 


Glu Asn Arg Glu Ala Val Leu Lys Asp His Thr Lys Ile Arg Ala Leu 
465                 470                 475                 480 


Val Arg Ala His Ser Glu Lys Asp Gln Pro Pro Phe Gly Asp Ser Asp 
                485                 490                 495     


Asp Ser Val Glu Ala Asp Lys Ser Ser Pro Gly Ile His Leu Glu Arg 
            500                 505                 510         


Ser Gln Ala Ser Thr Thr Val Asp Ile Asn Thr Gln Val Glu Lys Glu 
        515                 520                 525             


Val Pro Pro Gly Ser Ala Ile Ile His Ile Lys Lys His Gln Val Ser 
    530                 535                 540                 


Val Glu Gly Thr Asn Gln Thr Asp Val Lys Ala Val Gly Gly Pro Ala 
545                 550                 555                 560 


Lys Leu Leu Val Val Ser Leu Glu Glu Ala Trp Pro Leu His Gly Asp 
                565                 570                 575     


Cys Glu Thr Asp Ala Glu Glu Gly Thr Ser Leu Thr Ala Ser Val Val 
            580                 585                 590         


Ala Asp Val Arg Lys Ser Gln Leu Pro Ala Glu Gly Asp Ala Gly Ala 
        595                 600                 605             


Glu Trp Ala Ala Ala Val Leu Lys Gln Glu Arg Ala His Glu Val Gly 
    610                 615                 620                 


Ala Gln Gly Gly Pro Pro Val Ala Gln Val Glu Gln Asp Leu Pro Ile 
625                 630                 635                 640 


Ser Arg Glu Asn Leu Thr Asp Leu Val Val Asp Thr Asp Thr Leu Gly 
                645                 650                 655     


Glu Ser Thr Gln Pro Gln Arg Glu Gly Ala Gln Val Pro Thr Gly Arg 
            660                 665                 670         


Glu Arg Glu Gln His Val Gly Gly Thr Lys Asp Ser Glu Asp Asn Tyr 
        675                 680                 685             


Gly Asp Ser Glu Asp Leu Asp Leu Gln Ala Thr Gln Cys Phe Leu Glu 
    690                 695                 700                 


Asn Gln Gly Leu Glu Ala Val Gln Ser Met Glu Asp Glu Pro Thr Gln 
705                 710                 715                 720 


Ala Phe Met Leu Thr Pro Pro Gln Glu Leu Gly Pro Ser His Cys Ser 
                725                 730                 735     


Phe Gln Thr Thr Gly Thr Leu Asp Glu Pro Trp Glu Val Leu Ala Thr 
            740                 745                 750         


Gln Pro Phe Cys Leu Arg Glu Ser Glu Asp Ser Glu Thr Gln Pro Phe 
        755                 760                 765             


Asp Thr His Leu Glu Ala Tyr Gly Pro Cys Leu Ser Pro Pro Arg Ala 
    770                 775                 780                 


Ile Pro Gly Asp Gln His Pro Glu Ser Pro Val His Thr Glu Pro Met 
785                 790                 795                 800 


Gly Ile Gln Gly Arg Gly Arg Gln Thr Val Asp Lys Val Met Gly Ile 
                805                 810                 815     


Pro Lys Glu Thr Ala Glu Arg Val Gly Pro Glu Arg Gly Pro Leu Glu 
            820                 825                 830         


Arg Glu Thr Glu Lys Leu Leu Pro Glu Arg Gln Thr Asp Val Thr Gly 
        835                 840                 845             


Glu Glu Glu Leu Thr Lys Gly Lys Gln Asp Arg Glu Gln Lys Gln Leu 
    850                 855                 860                 


Leu Ala Arg Asp Thr Gln Arg Gln Glu Ser Asp Lys Asn Gly Glu Ser 
865                 870                 875                 880 


Ala Ser Pro Glu Arg Asp Arg Glu Ser Leu Lys Val Glu Ile Glu Thr 
                885                 890                 895     


Ser Glu Glu Ile Gln Glu Lys Gln Val Gln Lys Gln Thr Leu Pro Ser 
            900                 905                 910         


Lys Ala Phe Glu Arg Glu Val Glu Arg Pro Val Ala Asn Arg Glu Cys 
        915                 920                 925             


Asp Pro Ala Glu Leu Glu Glu Lys Val Pro Lys Val Ile Leu Glu Arg 
    930                 935                 940                 


Asp Thr Gln Arg Gly Glu Pro Glu Gly Gly Ser Gln Asp Gln Lys Gly 
945                 950                 955                 960 


Gln Ala Ser Ser Pro Thr Pro Glu Pro Gly Val Gly Ala Gly Asp Leu 
                965                 970                 975     


Pro Gly Pro Thr Ser Ala Pro Val Pro Ser Gly Ser Gln Ser Gly Gly 
            980                 985                 990         


Arg Gly Ser Pro Val Ser Pro Arg  Arg His Gln Lys Gly  Leu Leu Asn 
        995                 1000                 1005             


Cys Lys  Met Pro Pro Ala Glu  Lys Ala Ser Arg Ile  Arg Ala Ala 
    1010                 1015                 1020             


Glu Lys  Val Ser Arg Gly Asp  Gln Glu Ser Pro Asp  Ala Cys Leu 
    1025                 1030                 1035             


Pro Pro  Thr Val Pro Glu Ala  Pro Ala Pro Pro Gln  Lys Pro Leu 
    1040                 1045                 1050             


Asn Ser  Gln Ser Gln Lys His  Leu Ala Pro Pro Pro  Leu Leu Ser 
    1055                 1060                 1065             


Pro Leu  Leu Pro Ser Ile Lys  Pro Thr Val Arg Lys  Thr Arg Gln 
    1070                 1075                 1080             


Asp Gly  Ser Gln Glu Ala Pro  Glu Ala Pro Leu Ser  Ser Glu Leu 
    1085                 1090                 1095             


Glu Pro  Phe His Pro Lys Pro  Lys Ile Arg Thr Arg  Lys Ser Ser 
    1100                 1105                 1110             


Arg Met  Thr Pro Phe Pro Ala  Thr Ser Ala Ala Pro  Glu Pro His 
    1115                 1120                 1125             


Pro Ser  Thr Ser Thr Ala Gln  Pro Val Thr Pro Lys  Pro Thr Ser 
    1130                 1135                 1140             


Gln Ala  Thr Arg Ser Arg Thr  Asn Arg Ser Ser Val  Lys Thr Pro 
    1145                 1150                 1155             


Glu Pro  Val Val Pro Thr Ala  Pro Glu Leu Gln Pro  Ser Thr Ser 
    1160                 1165                 1170             


Thr Asp  Gln Pro Val Thr Ser  Glu Pro Thr Ser Gln  Val Thr Arg 
    1175                 1180                 1185             


Gly Arg  Lys Ser Arg Ser Ser  Val Lys Thr Pro Glu  Thr Val Val 
    1190                 1195                 1200             


Pro Thr  Ala Leu Glu Leu Gln  Pro Ser Thr Ser Thr  Asp Arg Pro 
    1205                 1210                 1215             


Val Thr  Ser Glu Pro Thr Ser  Gln Ala Thr Arg Gly  Arg Lys Asn 
    1220                 1225                 1230             


Arg Ser  Ser Val Lys Thr Pro  Glu Pro Val Val Pro  Thr Ala Pro 
    1235                 1240                 1245             


Glu Leu  Gln Pro Ser Thr Ser  Thr Asp Gln Pro Val  Thr Ser Glu 
    1250                 1255                 1260             


Pro Thr  Tyr Gln Ala Thr Arg  Gly Arg Lys Asn Arg  Ser Ser Val 
    1265                 1270                 1275             


Lys Thr  Pro Glu Pro Val Val  Pro Thr Ala Pro Glu  Leu Arg Pro 
    1280                 1285                 1290             


Ser Thr  Ser Thr Asp Arg Pro  Val Thr Pro Lys Pro  Thr Ser Arg 
    1295                 1300                 1305             


Thr Thr  Arg Ser Arg Thr Asn  Met Ser Ser Val Lys  Thr Pro Glu 
    1310                 1315                 1320             


Thr Val  Val Pro Thr Ala Pro  Glu Leu Gln Ile Ser  Thr Ser Thr 
    1325                 1330                 1335             


Asp Gln  Pro Val Thr Pro Lys  Pro Thr Ser Arg Thr  Thr Arg Ser 
    1340                 1345                 1350             


Arg Thr  Asn Met Ser Ser Val  Lys Asn Pro Glu Ser  Thr Val Pro 
    1355                 1360                 1365             


Ile Ala  Pro Glu Leu Pro Pro  Ser Thr Ser Thr Glu  Gln Pro Val 
    1370                 1375                 1380             


Thr Pro  Glu Pro Thr Ser Arg  Ala Thr Arg Gly Arg  Lys Asn Arg 
    1385                 1390                 1395             


Ser Ser  Gly Lys Thr Pro Glu  Thr Leu Val Pro Thr  Ala Pro Lys 
    1400                 1405                 1410             


Leu Glu  Pro Ser Thr Ser Thr  Asp Gln Pro Val Thr  Pro Glu Pro 
    1415                 1420                 1425             


Thr Ser  Gln Ala Thr Arg Gly  Arg Thr Asn Arg Ser  Ser Val Lys 
    1430                 1435                 1440             


Thr Pro  Glu Thr Val Val Pro  Thr Ala Pro Glu Leu  Gln Pro Ser 
    1445                 1450                 1455             


Thr Ser  Thr Asp Gln Pro Val  Thr Pro Glu Pro Thr  Ser Gln Ala 
    1460                 1465                 1470             


Thr Arg  Gly Arg Thr Asp Arg  Ser Ser Val Lys Thr  Pro Glu Thr 
    1475                 1480                 1485             


Val Val  Pro Thr Ala Pro Glu  Leu Gln Ala Ser Ala  Ser Thr Asp 
    1490                 1495                 1500             


Gln Pro  Val Thr Ser Glu Pro  Thr Ser Arg Thr Thr  Arg Gly Arg 
    1505                 1510                 1515             


Lys Asn  Arg Ser Ser Val Lys  Thr Pro Glu Thr Val  Val Pro Ala 
    1520                 1525                 1530             


Ala Pro  Glu Leu Gln Pro Ser  Thr Ser Thr Asp Gln  Pro Val Thr 
    1535                 1540                 1545             


Pro Glu  Pro Thr Ser Arg Ala  Thr Arg Gly Arg Thr  Asn Arg Ser 
    1550                 1555                 1560             


Ser Val  Lys Thr Pro Glu Ser  Ile Val Pro Ile Ala  Pro Glu Leu 
    1565                 1570                 1575             


Gln Pro  Ser Thr Ser Arg Asn  Gln Leu Val Thr Pro  Glu Pro Thr 
    1580                 1585                 1590             


Ser Arg  Ala Thr Arg Cys Arg  Thr Asn Arg Ser Ser  Val Lys Thr 
    1595                 1600                 1605             


Pro Glu  Pro Val Val Pro Thr  Ala Pro Glu Pro His  Pro Thr Thr 
    1610                 1615                 1620             


Ser Thr  Asp Gln Pro Val Thr  Pro Lys Leu Thr Ser  Arg Ala Thr 
    1625                 1630                 1635             


Arg Arg  Lys Thr Asn Arg Ser  Ser Val Lys Thr Pro  Lys Pro Val 
    1640                 1645                 1650             


Glu Pro  Ala Ala Ser Asp Leu  Glu Pro Phe Thr Pro  Thr Asp Gln 
    1655                 1660                 1665             


Ser Val  Thr Pro Glu Ala Ile  Ala Gln Gly Gly Gln  Ser Lys Thr 
    1670                 1675                 1680             


Leu Arg  Ser Ser Thr Val Arg  Ala Met Pro Val Pro  Thr Thr Pro 
    1685                 1690                 1695             


Glu Phe  Gln Ser Pro Val Thr  Thr Asp Gln Pro Ile  Ser Pro Glu 
    1700                 1705                 1710             


Pro Ile  Thr Gln Pro Ser Cys  Ile Lys Arg Gln Arg  Ala Ala Gly 
    1715                 1720                 1725             


Asn Pro  Gly Ser Leu Ala Ala  Pro Ile Asp His Lys  Pro Cys Ser 
    1730                 1735                 1740             


Ala Pro  Leu Glu Pro Lys Ser  Gln Ala Ser Arg Asn  Gln Arg Trp 
    1745                 1750                 1755             


Gly Ala  Val Arg Ala Ala Glu  Ser Leu Thr Ala Ile  Pro Glu Pro 
    1760                 1765                 1770             


Ala Ser  Pro Gln Leu Leu Glu  Thr Pro Ile His Ala  Ser Gln Ile 
    1775                 1780                 1785             


Gln Lys  Val Glu Pro Ala Gly  Arg Ser Arg Phe Thr  Pro Glu Leu 
    1790                 1795                 1800             


Gln Pro  Lys Ala Ser Gln Ser  Arg Lys Arg Ser Leu  Ala Thr Met 
    1805                 1810                 1815             


Asp Ser  Pro Pro His Gln Lys  Gln Pro Gln Arg Gly  Glu Val Ser 
    1820                 1825                 1830             


Gln Lys  Thr Val Ile Ile Lys  Glu Glu Glu Glu Asp  Thr Ala Glu 
    1835                 1840                 1845             


Lys Pro  Gly Lys Glu Glu Asp  Val Val Thr Pro Lys  Pro Gly Lys 
    1850                 1855                 1860             


Arg Lys  Arg Asp Gln Ala Glu  Glu Glu Pro Asn Arg  Ile Pro Ser 
    1865                 1870                 1875             


Arg Ser  Leu Arg Arg Thr Lys  Leu Asn Gln Glu Ser  Thr Ala Pro 
    1880                 1885                 1890             


Lys Val  Leu Phe Thr Gly Val  Val Asp Ala Arg Gly  Glu Arg Ala 
    1895                 1900                 1905             


Val Leu  Ala Leu Gly Gly Ser  Leu Ala Gly Ser Ala  Ala Glu Ala 
    1910                 1915                 1920             


Ser His  Leu Val Thr Asp Arg  Ile Arg Arg Thr Val  Lys Phe Leu 
    1925                 1930                 1935             


Cys Ala  Leu Gly Arg Gly Ile  Pro Ile Leu Ser Leu  Asp Trp Leu 
    1940                 1945                 1950             


His Gln  Ser Arg Lys Ala Gly  Phe Phe Leu Pro Pro  Asp Glu Tyr 
    1955                 1960                 1965             


Val Val  Thr Asp Pro Glu Gln  Glu Lys Asn Phe Gly  Phe Ser Leu 
    1970                 1975                 1980             


Gln Asp  Ala Leu Ser Arg Ala  Arg Glu Arg Arg Leu  Leu Glu Gly 
    1985                 1990                 1995             


Tyr Glu  Ile Tyr Val Thr Pro  Gly Val Gln Pro Pro  Pro Pro Gln 
    2000                 2005                 2010             


Met Gly  Glu Ile Ile Ser Cys  Cys Gly Gly Thr Tyr  Leu Pro Ser 
    2015                 2020                 2025             


Met Pro  Arg Ser Tyr Lys Pro  Gln Arg Val Val Ile  Thr Cys Pro 
    2030                 2035                 2040             


Gln Asp  Phe Pro His Cys Ser  Ile Pro Leu Arg Val  Gly Leu Pro 
    2045                 2050                 2055             


Leu Leu  Ser Pro Glu Phe Leu  Leu Thr Gly Val Leu  Lys Gln Glu 
    2060                 2065                 2070             


Ala Lys  Pro Glu Ala Phe Val  Leu Ser Pro Leu Glu  Met Ser Ser 
    2075                 2080                 2085             


Thr 
    


<210> 6
<211> 7385
<212> DNA
<213> Homo sapiens

<400> 6
caccatgtct aggaggaccg aggaaaggcg ctctggcctt accagacacg tcggacgtct       60

atgacacagc ccctctatcc gttgccggca gctggcgcca gactctctgg tcgcggtttg      120

gaactgcgcg ggaagtgggt ggtgggcggg caagcggtag tgggttgtcc cttggagctg      180

cccaatcgac gtgcattatt ctgttggcgc acggcggcct tcaattaccg tctcattaac      240

tgatctcagc agcctgggag acaccaccta tttgaactct aagggggcgg ggctttgggt      300

gtgcctccgc tcgactggct gcggttgtga aagacagcgg cagaagccaa tcagcaaata      360

agctcttttt cggcacacgc agtcgctcca cctgggtcgc gaccgttact ggtggcgcgc      420

gcggggactt aaagtagatc atggaggaca cccaggctat tgactgggat gttgaagaag      480

aggaggagac agagcaatcc agtgaatcct tgaggtgtaa cgtggagcca gtagggcggc      540

tacatatctt tagtggtgcc catggaccag aaaaagattt cccactacac ctcgggaaga      600

atgtggtagg ccgaatgcct gactgctctg tggccctgcc ctttccatct atctccaaac      660

aacatgcaga gattgaaatc ttagcctggg acaaggcacc tatcctccga gactgtggga      720

gccttaatgg tactcaaatc ctgagacctc ctaaggtttt gagccctggg gtgagtcacc      780

gtctgaggga ccaggaattg attctctttg ctgacttgct ctgccagtac catcgcctgg      840

atgtctctct gccctttgtc tcccggggcc ctctgacagt agaagagaca cccagagtac      900

agggagaaac tcaaccccag aggcttctgt tggctgagga ctcggaggag gaagtagatt      960

ttctttctga aaggcgtatg gtaaaaaaat caaggaccac atcttcctct gtgatagttc     1020

cagagagtga tgaagagggg cattccccgg tcctgggcgg ccttgggccg ccttttgcct     1080

tcaatttgaa cagtgacaca gatgtggaag aaggtcagca accagccaca gaggaggcct     1140

cctcagctgc cagaagaggt gccactgtag aggcaaagca gtctgaagct gaagttgtaa     1200

ctgaaatcca gcttgaaaag gatcagcctt tagtgaagga gagggacaat gatacaaaag     1260

tcaagagggg tgcagggaat ggggtggttc cagctggggt gattctggag aggagccaac     1320

ctcctggaga ggacagtgac acagatgtgg atgatgacag caggcctcct ggaaggccag     1380

ctgaggtcca tttggaaagg gctcagcctt ttggcttcat cgacagcgac actgatgcgg     1440

aagaagagag gatcccagca accccagttg tcattcctat gaagaagagg aagatcttcc     1500

atggagtagg tacaaggggt cctggagcac caggcctggc ccatctgcag gagagccagg     1560

ctggtagtga tacagatgtg gaagaaggca aggccccaca ggctgtccct ctggagaaaa     1620

gccaagcttc catggttatc aacagcgata cagatgacga ggaagaagtc tcagcagcgc     1680

tgactttggc acatctgaaa gagagccagc ctgctatatg gaacagagat gcagaagagg     1740

acatgcccca acgtgtggtc cttctgcagc gaagccaaac caccactgag agagacagtg     1800

acacagacgt ggaggaggaa gagctcccag tggaaaatag agaagctgtc ctcaaggatc     1860

acacaaagat tagagccctt gttagagcac attcagaaaa ggaccaacct ccttttgggg     1920

acagtgatga cagtgtggaa gcagataaga gctcacctgg gatccacctg gagagaagcc     1980

aagcctccac cacagtggac atcaacacac aagtggagaa ggaagtcccg ccagggtcag     2040

ccattataca tataaagaag catcaggtgt ctgtggaggg gacaaatcaa acagatgtga     2100

aagcagttgg gggaccagca aagctgcttg tggtatctct agaggaagcc tggcctctgc     2160

atggggactg tgaaacagat gcagaggagg gcacctccct aacagcctca gtagttgcag     2220

atgtaagaaa gagccagctt ccagcagaag gggatgctgg ggcagagtgg gctgcagctg     2280

ttcttaagca ggagagagct catgaggtgg gggcccaggg tgggccacct gtggcacaag     2340

tggagcagga cctccctatc tcaagagaga acctcacaga tctggtggtg gacacagaca     2400

ctctagggga atccacccag ccacagagag agggagccca ggtccccaca ggaagggaga     2460

gagaacaaca tgtgggtggg accaaggact ctgaagacaa ctatggtgat tctgaagatc     2520

tggacctaca agctacccag tgctttctgg agaatcaggg cctggaagca gtccagagca     2580

tggaggatga acctacccag gccttcatgt tgactccacc ccaagagctt ggcccttccc     2640

attgcagctt ccagacaaca ggtaccctag atgaaccatg ggaggtcctg gctacacagc     2700

cattctgtct gagagagtct gaggactctg agacccagcc ttttgacacg caccttgagg     2760

cctatggacc ttgcctgtct ccacctaggg caataccagg agaccaacat ccagagagcc     2820

cagttcacac agagccaatg gggattcaag gcagagggag gcagactgtg gataaagtca     2880

tgggtatacc aaaagaaaca gcagagaggg tgggccctga gagagggcca ttggagagag     2940

aaactgagaa actgctacca gaaagacaga cagatgtgac aggagaggaa gaattaacca     3000

aggggaaaca ggacagagaa caaaaacagt tgttagctag agacacccag agacaagaat     3060

ctgacaaaaa tggggaaagt gcaagtcctg aaagagatag ggagagtttg aaggtagaaa     3120

ttgagacatc tgaggaaata caagagaaac aagtacagaa gcagaccctt ccaagcaaag     3180

catttgagag agaagtagag agaccagtag caaacagaga gtgcgatcca gccgagttag     3240

aagagaaggt gcccaaagtg atcctggaga gagatacaca gagaggggag ccagagggag     3300

ggagccagga ccagaaaggg caggcctcca gcccaacacc agagcctggg gtgggggcgg     3360

gggaccttcc gggacctacc tcagcccccg taccttctgg gagccagtca ggtggaaggg     3420

gatccccagt gagccccagg aggcatcaga aaggcctcct gaattgcaag atgccacctg     3480

ctgagaaggc ttccaggatc agagctgctg agaaggtttc caggggcgat caggaatctc     3540

cagatgcttg tctgcctcct acagtacctg aagccccagc cccaccccaa aagcccctta     3600

actctcagag ccagaaacat cttgcacctc cgccccttct ttctcccctt ttaccttcta     3660

tcaagccaac cgttcgtaag accaggcaag atgggagtca ggaagctcca gaggctccct     3720

tgtcctcaga gctggagcct ttccacccaa agcctaaaat tagaactcgg aagtcctcca     3780

gaatgacacc ctttccagct acctctgctg cccctgagcc ccacccttcc acctccacag     3840

cccagccagt cactcccaag cccacatctc aggccactag gagcaggaca aataggtcct     3900

ctgtcaagac ccctgaacca gttgtcccca cagcccctga gctccagcct tccacctcca     3960

cagaccagcc tgtcacctct gagcccacat ctcaggttac taggggaaga aaaagtagat     4020

cctctgtcaa gacccctgaa acagttgtgc ccacagccct tgagctccag ccttccacct     4080

ccaccgaccg acctgtcacc tctgaaccca cctctcaggc tactagggga agaaaaaata     4140

gatcctctgt caagacccct gaaccagttg tccccacagc ccctgagctc cagccttcca     4200

cctccacaga ccagcctgtc acttctgagc ccacatatca ggctactagg ggaagaaaaa     4260

atagatcctc tgtcaagacc cctgaaccag ttgtgcccac agcccctgag ctccggcctt     4320

ccacctccac agaccgacct gtcaccccca agcccacatc tcggaccact aggagcagga     4380

caaatatgtc ctctgtcaag acccctgaaa cagttgtccc cacagcccct gagctccaga     4440

tttccacctc cacagaccaa cctgtcaccc ctaagcccac atctcggacc actaggagca     4500

ggacaaatat gtcctctgtg aagaaccctg aatcaactgt ccctatagcc cctgagctcc     4560

caccttccac ctccacagag cagcctgtca cccctgagcc cacatctcgg gctactaggg     4620

gaagaaaaaa tagatcctct ggcaagaccc ctgaaacact tgtccccaca gcccctaagc     4680

tcgagccttc cacttccaca gaccaacctg tcactcctga gcccacatct caggccacca     4740

ggggcaggac aaataggtcc tctgtgaaga cccctgaaac agttgtcccc acagcccctg     4800

agctccagcc ttccacctcc acagaccagc ctgttacccc tgagcctacg tctcaggcta     4860

ctaggggaag aacagataga tcctctgtca agactcctga aacagttgtc cccacagccc     4920

ctgagctaca ggcttccgcc tccacagacc agcctgtcac ctctgagccc acatctcgga     4980

ccactagggg aagaaaaaat cggtcctctg tcaagacccc tgaaacagtt gtgcccgcag     5040

cccctgagct ccagccttcc acctccacag accaacctgt cacccctgag cccacatctc     5100

gggccactag gggcaggaca aataggtcct ctgtcaagac ccctgaatca attgtcccta     5160

tagcccctga gcttcagcct tccacctcca gaaaccagct tgtcacccct gagcccacat     5220

ctcgggccac taggtgcagg acaaataggt cctctgtcaa gacccctgag ccagttgtcc     5280

ccacagcccc tgagccccat cctaccacct ccacagacca gcctgtcacc cccaagctca     5340

catctagggc cactaggaga aagacaaata ggtcctctgt caagactccc aaaccagttg     5400

aaccagcagc ctctgatctt gagcctttta cccccacaga ccagtccgtc acccctgagg     5460

ccatagctca gggtggtcag agcaaaacac tgaggtcttc cacagtaaga gctatgccgg     5520

ttcctaccac ccctgaattc caatctcctg tcaccacaga ccagcctatt tcccctgagc     5580

ctattactca acccagttgc atcaagaggc agagagccgc tgggaaccct ggctccctcg     5640

cagctcccat tgaccataag ccttgctctg cacccttgga acctaaatcc caggcctcaa     5700

ggaaccaaag atggggagca gtgagagcag ctgaatccct tacagccatt cctgagcctg     5760

cctctcccca gcttcttgag acaccaattc atgcctccca gatccaaaag gtggaaccag     5820

caggtagatc taggttcacc ccggagctcc agcctaaggc ctctcaaagc cgcaagaggt     5880

ctttagctac catggattca ccaccacatc aaaaacagcc ccaaagaggg gaagtctccc     5940

agaagacagt gattatcaag gaagaggaag aagatactgc agagaagcca gggaaggaag     6000

aggatgtcgt gactccaaaa ccaggcaaga gaaagagaga ccaggcagag gaggagccca     6060

acagaatacc aagccgcagc ctccgacgga ccaaacttaa ccaagaatca acagccccca     6120

aagtgctctt cacaggagtg gtggatgctc ggggagagcg ggctgtgctg gcactggggg     6180

gaagtctggc tggttcagcg gcagaggctt cccacctggt cactgatcgc atccgccgga     6240

cagtcaagtt cctgtgtgcc ctggggcggg gaatccccat tctgtccctg gactggctgc     6300

atcagtcccg caaggctggt ttcttcttac ccccggatga atatgtggtg accgaccctg     6360

agcaagagaa gaactttggc tttagccttc aagacgcact gagcagggct cgggagcgaa     6420

ggctgctaga gggctatgag atctatgtga cccctggagt ccagccacca ccacctcaga     6480

tgggagagat tattagctgc tgtggaggca catacctacc cagcatgcct cggtcctata     6540

agcctcagag agttgtgatc acatgccctc aggacttccc tcattgctcc attccactac     6600

gggttgggct gcccctcctc tcgcctgagt tcctgctgac tggagtgctg aagcaggaag     6660

ccaagccaga ggcctttgtc ctctcccctt tggagatgtc atccacctga gaactccact     6720

acccttttcc ctcccagacc acgaattaga agatatgtgg aagaaagaac tcagggcgtt     6780

agaaaggatt ggggtatatt gatacaactt gtcctggaac atgggtggga ccagaaatct     6840

ttatgaataa atgaaaagat aagggatttg gaagccacag gttgtttttt gtttgtttgt     6900

ttgttttttt aatggccatt ttattttatt tgtatttata gttttttatt tgtatagatt     6960

taggggatac aagatttctt acatgcatgt attaaatggc cattttaaaa ttagctagtt     7020

tcatgctcag atgtcataag tggcagctat ctttagccag actgttgcag ttattgctcg     7080

atgccactca tggtgtccta cctcctattt ggaaaccatc tctatttttt tcttactgag     7140

attcttactt tggggtcagg aacttgaagg gatgcttgga gtgagtagat ttgagggtcc     7200

agttatggag tgctactaaa acattttctt ctctcctggc ctctggaagc atctttagct     7260

ttgactttgg gcaagtctct gtacttttct ggccagcttt tccaggattt ataaaattag     7320

agcttcggct tgacctctgt gataaataaa tattcactct gtgccttaaa aaaaaaaaaa     7380

aaaaa                                                                 7385


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gcacgctaca acaccaagtt t                                                 21


<210> 8
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gcacagtctt cggaagagag acacaatca                                         29


<210> 9
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 10
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Mono-methylated-Lys

<400> 10
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 11
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Di-methylated-Lys

<400> 11
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 12
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Tri-methylated-Lys

<400> 12
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 13
<211> 10
<212> PRT
<213> Homo sapiens

<400> 13
Glu Asp Gln His Thr Gln Ile Thr Lys Val 
1               5                   10  


<210> 14
<211> 10
<212> PRT
<213> Mus sp.

<400> 14
Glu Asp Gln His Ser Gln Ile Thr Lys Val 
1               5                   10  


<210> 15
<211> 12
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Di-methylated-Lys

<400> 15
Phe Thr Lys Thr Val Glu Glu Pro Ser Asn Pro Glu 
1               5                   10          


<210> 16
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Di-methylated-Lys

<400> 16
Phe Thr Lys Thr Val Glu Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser 
1               5                   10                  15      


Thr Ser Val Thr Pro Asp Val Ser Asp Asn Glu Pro Asp His Tyr 
            20                  25                  30      


<210> 17
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Di-methylated-Lys

<400> 17
Tyr His Asp Pro Glu Asn Asp Ser Val Asp Pro Thr Val Ser Thr Ser 
1               5                   10                  15      


Ser Ser Ala Glu Pro Asn Ser Pro Glu Glu Val Thr Lys Thr Phe 
            20                  25                  30      


<210> 18
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Di-methylated-Lys

<400> 18
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 19
<211> 19
<212> PRT
<213> Mus sp.


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Di-methylated-Lys

<400> 19
Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 20
<211> 19
<212> PRT
<213> Xenopus sp.


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Di-methylated-Lys

<400> 20
Asn Phe Lys Val Lys Leu Phe Phe Thr Lys Thr Val Glu Glu Ser Ser 
1               5                   10                  15      


Asn Pro Glu 
            


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Lys Lys Ala Thr Gln Ala Ser Gln Glu Tyr 
1               5                   10      


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Phospho-Ser

<400> 22
Gly Lys Lys Ala Thr Gln Ala Ser Gln Glu Tyr 
1               5                   10      


