                         SEQUENCE LISTING

<110>  THE CLEVELAND CLINIC FOUNDATION
       GEORGIA TECH RESEARCH CORPORATION
 
<120>  C5 IMMUNIZATION FOR AUTOLOGOUS ANTI-C5 ANTIBODY PRODUCTION

<130>  CCF-34996/WO-1/ORD

<150>  US 62/380,824
<151>  2016-08-29

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Ile Ser Ala Asp Ser Arg Lys Glu Lys Ala Cys Lys Pro Glu Ala Ser 
1               5                   10                  15      


Tyr Lys Pro Ser Lys Glu Glu Ser Thr Ser Gly Ser Ala Lys Phe Val 
            20                  25                  30          


Ala Ala Trp Thr Leu Lys Ala Gln Glu Thr Ser Asp Leu Glu Thr Lys 
        35                  40                  45              


Arg Ser Ile Thr His Lys Cys Gln Leu Glu Asn Gly Ser Phe Lys Glu 
    50                  55                  60                  


Asn Ser Gln Asn Ala Asn Ala Asp Asp Ser His Tyr Arg Asp Asp Ser 
65                  70                  75                  80  


Tyr Ser Leu Gly Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Leu Pro 
                85                  90                  95      


Glu Glu Asn Gln Ala Ser Lys Glu Tyr Glu Ala Val Ala Lys Phe Val 
            100                 105                 110         


Ala Ala Trp Thr Leu Lys Ala Lys Thr Gly Glu Ala Ala Asp Glu Asn 
        115                 120                 125             


Ser Glu Val Thr Phe Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser 
    130                 135                 140                 


Tyr Ala Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala His Thr 
145                 150                 155                 160 


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Lys Ser Asp Leu 
                165                 170                 175     


Gly Cys Gly Ala Gly Gly Gly His Asp Asn Ala Lys Phe Val Ala Ala 
            180                 185                 190         


Trp Thr Leu Lys Ala Asp Thr Leu Lys Arg Pro Asp Ser Ser Val Pro 
        195                 200                 205             


Ser Ser Gly His His His His His His 
    210                 215         


<210>  2
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

Ala Tyr Gly Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala 
1               5                   10                  15      


Ala Gly Ser Gly Ala Ser Tyr Lys Pro Ser Lys Glu Glu Ser Thr Ser 
            20                  25                  30          


Gly Ser 
        


<210>  3
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  3

Ile Ser Ala Asp Ser Arg Lys Glu Lys Ala Cys Lys Pro Glu 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  4

Ala Ser Tyr Lys Pro Ser Lys Glu Glu Ser Thr Ser Gly Ser 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Glu Thr Ser Asp Leu Glu Thr Lys Arg Ser Ile Thr His 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Cys Gln Leu Glu Asn Gly Ser Phe Lys Glu Asn Ser Gln 
1               5                   10                  


<210>  7
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  7

Asn Ala Asn Ala Asp Asp Ser His Tyr Arg Asp Asp Ser 
1               5                   10              


<210>  8
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  8

Tyr Ser Leu Gly Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  9

Leu Pro Glu Glu Asn Gln Ala Ser Lys Glu Tyr Glu Ala Val 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  10

Lys Thr Gly Glu Ala Ala Asp Glu Asn Ser Glu Val Thr Phe 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  11

Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ala Gly 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly His Asp Asn 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  13

His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Thr Leu Lys Arg Pro Asp Ser Ser Val Pro Ser Ser Gly 
1               5                   10                  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  15

Ile Ser Ala Asp Ser Arg Lys Glu Lys Ala Cys Lys Pro Glu Ala 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  16

Ala Cys Lys Pro Glu Ala Ser Tyr Lys Pro Ser Lys Glu Glu Ser 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  17

Pro Ser Lys Glu Glu Ser Thr Ser Gly Ser Ala Lys Phe Val Ala 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  18

Ser Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Gln Glu Thr 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  19

Leu Lys Ala Gln Glu Thr Ser Asp Leu Glu Thr Lys Arg Ser Ile 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  20

Glu Thr Lys Arg Ser Ile Thr His Lys Cys Gln Leu Glu Asn Gly 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  21

Cys Gln Leu Glu Asn Gly Ser Phe Lys Glu Asn Ser Gln Asn Ala 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Glu Asn Ser Gln Asn Ala Asn Ala Asp Asp Ser His Tyr Arg Asp 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  23

Asp Ser His Tyr Arg Asp Asp Ser Tyr Ser Leu Gly Asp Asp Leu 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

Ser Leu Gly Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Leu Pro 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

Lys Arg Glu Thr Leu Pro Glu Glu Asn Gln Ala Ser Lys Glu Tyr 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Gln Ala Ser Lys Glu Tyr Glu Ala Val Ala Lys Phe Val Ala Ala 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  27

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Lys Thr Gly Glu 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Ala Lys Thr Gly Glu Ala Ala Asp Glu Asn Ser Glu Val Thr 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  29

Glu Asn Ser Glu Val Thr Phe Arg Val Val Pro Glu Gly Val Lys 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  30

Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ala Gly Ala Lys Phe 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  31

Tyr Ala Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala His 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  32

Trp Thr Leu Lys Ala His Thr Asp Lys Pro Val Tyr Thr Pro Asp 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  33

Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Lys Ser Asp Leu Gly 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  34

Lys Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly His Asp Asn 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  35

Gly Gly Gly His Asp Asn Ala Lys Phe Val Ala Ala Trp Thr Leu 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  36

Val Ala Ala Trp Thr Leu Lys Ala Asp Thr Leu Lys Arg Pro Asp 
1               5                   10                  15  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  37

Thr Leu Lys Arg Pro Asp Ser Ser Val Pro Ser Ser Gly 
1               5                   10              


<210>  38
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  38

Asp Thr Leu Lys Arg Pro Asp Ser Ser Val Pro Ser Ser Gly 
1               5                   10                  


<210>  39
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  39

Ala Cys Lys Pro Glu Ala Ser Tyr Lys Pro Ser Lys Glu Glu Ser 
1               5                   10                  15  


<210>  40
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  40

Ile Ser Ala Glu Thr Arg Lys Gln Thr Ala Cys Lys Pro Glu 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Ser Tyr Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly Ser 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Glu Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  43

Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys Glu Asn Ser Gln 
1               5                   10                  


<210>  44
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro 
1               5                   10              


<210>  45
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  45

Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Pro Glu Glu Asn Gln Ala Arg Glu Gly Tyr Arg Ala Ile 
1               5                   10                  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  47

Lys Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile Thr Phe 
1               5                   10                  15  


<210>  48
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
1               5                   10                  


<210>  50
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  50

His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val 
1               5                   10              


<210>  51
<400>  51


<210>  52
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Asn Leu Gln His Lys Asp Ser Ser Val Pro Asn Thr Gly 
1               5                   10                  


<210>  53
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Ala Glu Thr Arg Lys Gln Thr Ala Cys Lys Pro 
1               5                   10          


<210>  54
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Leu Thr Ile Ser Ala Glu Thr Arg Lys Gln Thr Ala Cys Lys Pro 
1               5                   10                  15      


Glu Ile Ala Tyr 
            20  


<210>  55
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Tyr Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly 
1               5                   10          


<210>  56
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  56

Val Ala Cys Ala Ser Tyr Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly 
1               5                   10                  15      


Ser Ser His Ala 
            20  


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr 
1               5                   10          


<210>  58
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Val Asn Gln Glu Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr 
1               5                   10                  15      


Arg Val Asp Asp 
            20  


<210>  59
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  59

Tyr Gln Leu Asp Asn Gly Ser Phe Lys Glu Asn Ser 
1               5                   10          


<210>  60
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Val Glu Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys Glu Asn Ser 
1               5                   10                  15      


Gln Tyr Gln Pro 
            20  


<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu 
1               5                   10      


<210>  62
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  62

Phe Leu Thr Asn Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro 
1               5                   10                  15      


Cys Lys Glu 
            


<210>  63
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu 
1               5                   10          


<210>  64
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  64

Val Arg Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu 
1               5                   10                  15      


Thr Val Leu Thr 
            20  


<210>  65
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  65

Pro Glu Glu Asn Gln Ala Arg Glu Gly Tyr Arg Ala 
1               5                   10          


<210>  66
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu Gly Tyr Arg Ala 
1               5                   10                  15      


Ile Ala Tyr Ser 
            20  


<210>  67
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  67

Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile Thr 
1               5                   10              


<210>  68
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  68

Asp Ile Tyr Lys Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile 
1               5                   10                  15      


Thr Phe Ile Lys Lys 
            20      


<210>  69
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser 
1               5                   10          


<210>  70
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  70

Lys Thr Leu Arg Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser 
1               5                   10                  15      


Gly Val Thr Leu 
            20  


<210>  71
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  71

Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn 
1               5                   10          


<210>  72
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn 
1               5                   10                  15      


Asn Ala Asn Val 
            20  


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser 
1               5                   10      


<210>  74
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  74

Leu Phe Ile His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val 
1               5                   10                  15      


Lys Val Arg Val 
            20  


<210>  75
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  75

Asn Leu Gln His Lys Asp Ser Ser Val Pro Asn Thr 
1               5                   10          


<210>  76
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  76

Phe Trp Lys Asp Asn Leu Gln His Lys Asp Ser Ser Val Pro Asn Thr 
1               5                   10                  15      


Gly Thr Ala Arg 
            20  

    


