                     SEQUENCE LISTING

<110>  NGM Biopharmaceuticals, Inc.
       LING, Lei
       TIAN, Hui
 
<120>  METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS 

<130>  13370-065-228

<140>  
<141>  

<150>  62/380,973
<151>  2016-08-29 

<160>  208   

<170>  PatentIn version 3.5

<210>  1
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  2
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  3
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  4
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Ala Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  5
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  6
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  7
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  8
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  9
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  10
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  11
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  12
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  13
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  14
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  15
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  16
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  17
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  18
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Tyr Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  19
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val Tyr Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  20
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  21
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  22
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Gly Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  23
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  24
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  25
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  26
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  27
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro His Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  28
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Trp Gly Asp Pro 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  29
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  30
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Ala Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  31
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Ala Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  32
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  33
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Pro Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  34
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Ala 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  35
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Glu 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  36
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  37
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Ala Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  38
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  39
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Thr Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  40
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 
1               5                   10                  15      


Gln Pro Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  41
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  42
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  42

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  43
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  43

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Gly 
1               5                   10                  15      


Asp Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  44
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
            20                  25                  30          


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
        35                  40                  45              


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
    50                  55                  60                  


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
65                  70                  75                  80  


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
                85                  90                  95      


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
            100                 105                 110         


Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro 
        115                 120                 125             


His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 
    130                 135                 140                 


Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 
145                 150                 155                 160 


Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser 
                165                 170                 175     


Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            180                 185 


<210>  45
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  45

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  46
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
            20                  25                  30          


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
        35                  40                  45              


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
    50                  55                  60                  


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
65                  70                  75                  80  


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
                85                  90                  95      


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
            100                 105                 110         


Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro 
        115                 120                 125             


His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 
    130                 135                 140                 


Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 
145                 150                 155                 160 


Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser 
                165                 170                 175     


Gln Gly Arg Ser Pro Ser Tyr Ala Ser Pro Met Val Pro Glu Glu Pro 
            180                 185                 190         


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
        195                 200                 205             


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
    210                 215                 220                 


Val Arg Ser Pro Ser Phe Glu Lys 
225                 230         


<210>  47
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  47

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  48
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  49
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  49

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  50
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  51
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  51

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  52
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  53
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg 
1               5                   10                  15      


Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 
            20                  25                  30          


Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 
        35                  40                  45              


Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 
    50                  55                  60                  


Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 
                85                  90                  95      


Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 
            100                 105                 110         


Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 
        115                 120                 125             


Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 
    130                 135                 140                 


Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 
145                 150                 155                 160 


Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 
                165                 170                 175     


Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 


<210>  54
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  54

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  55
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Tyr Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  56
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  56

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val Tyr Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  57
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  57

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  58
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  58

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  59
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  59

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  60
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  60

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  61
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  62
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  62

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Tyr Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  63
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  63

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  64
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  64

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  65
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro His Val His Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  66
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  66

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Leu Gln Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  67
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Trp Gly Asp Pro 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  68
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  68

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  69
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  69

Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg 
1               5                   10                  15      


Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 
            20                  25                  30          


Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 
        35                  40                  45              


Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 
    50                  55                  60                  


Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 
                85                  90                  95      


Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 
            100                 105                 110         


Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 
        115                 120                 125             


Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 
    130                 135                 140                 


Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 
145                 150                 155                 160 


Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 
                165                 170                 175     


Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 


<210>  70
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  71
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  71

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Ser Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  72
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  72

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  73
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  73

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Val Gln Asp Glu Leu Gln Gly 
                165                 170                 175     


Val Gly Gly Glu Gly Cys His Met His Pro Glu Asn Cys Lys Thr Leu 
            180                 185                 190         


Leu Thr Asp Ile Asp Arg Thr His Thr Glu Lys Pro Val Trp Asp Gly 
        195                 200                 205             


Ile Thr Gly Glu 
    210         


<210>  74
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Asp Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg 
1               5                   10                  15      


Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 
            20                  25                  30          


Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 
        35                  40                  45              


Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 
    50                  55                  60                  


Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 
                85                  90                  95      


Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 
            100                 105                 110         


Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 
        115                 120                 125             


Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 
    130                 135                 140                 


Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 
145                 150                 155                 160 


Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 
                165                 170                 175     


Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 


<210>  75
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  75

Arg Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
1               5                   10                  15      


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
            20                  25                  30          


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
        35                  40                  45              


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
    50                  55                  60                  


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
65                  70                  75                  80  


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
                85                  90                  95      


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
            100                 105                 110         


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
        115                 120                 125             


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
    130                 135                 140                 


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
145                 150                 155                 160 


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
                165                 170                 175     


Val Arg Ser Pro Ser Phe Glu Lys 
            180                 


<210>  76
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  76

Arg Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His 
1               5                   10                  15      


Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp 
            20                  25                  30          


Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val 
        35                  40                  45              


Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu 
    50                  55                  60                  


Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu 
65                  70                  75                  80  


Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val 
                85                  90                  95      


Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys 
            100                 105                 110         


Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe 
        115                 120                 125             


Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly 
    130                 135                 140                 


His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met 
145                 150                 155                 160 


Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser 
                165                 170                 175     


Phe Glu Lys 
            


<210>  77
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
1               5                   10                  15      


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
            20                  25                  30          


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
        35                  40                  45              


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
    50                  55                  60                  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
65                  70                  75                  80  


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
                85                  90                  95      


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
            100                 105                 110         


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
        115                 120                 125             


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
    130                 135                 140                 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
145                 150                 155                 160 


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
                165                 170                 175 


<210>  78
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  78

Arg Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 
1               5                   10                  15      


Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu 
            20                  25                  30          


Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala 
        35                  40                  45              


His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 
    50                  55                  60                  


Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 
65                  70                  75                  80  


Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu 
                85                  90                  95      


Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg 
            100                 105                 110         


Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn 
        115                 120                 125             


Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val 
    130                 135                 140                 


Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe 
145                 150                 155                 160 


Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 
                165                 170                 175     


Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185             


<210>  79
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  79

Arg Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  80
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  80

Arg Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His 
1               5                   10                  15      


Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 
            20                  25                  30          


Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 
        35                  40                  45              


Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly 
    50                  55                  60                  


Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile 
                85                  90                  95      


Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro 
            100                 105                 110         


Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 
        115                 120                 125             


Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 
    130                 135                 140                 


Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 
145                 150                 155                 160 


Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 
                165                 170                 175     


Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185     


<210>  81
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  81

Arg His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu 
1               5                   10                  15      


Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg 
            20                  25                  30          


Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu 
        35                  40                  45              


Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val 
    50                  55                  60                  


His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly 
65                  70                  75                  80  


Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg 
                85                  90                  95      


Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val 
            100                 105                 110         


Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe 
        115                 120                 125             


Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu 
    130                 135                 140                 


Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro 
145                 150                 155                 160 


Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu 
                165                 170                 175     


Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185 


<210>  82
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  82

Arg Pro Leu Ala Phe Ser Ala Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  83
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  83

Arg Pro Leu Ala Phe Ser Asp Ala Ala Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  84
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  84

Arg Pro Leu Ala Phe Ser Asp Ala Gly Ala His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  85
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Ala 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  86
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  86

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Ala Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  87
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  87

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Ala Ile Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu 
            20                  25                  30          


Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser 
        35                  40                  45              


Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu 
    50                  55                  60                  


Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp 
65                  70                  75                  80  


Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu 
                85                  90                  95      


Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro 
            100                 105                 110         


Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu 
        115                 120                 125             


Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu 
    130                 135                 140                 


Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val 
145                 150                 155                 160 


Arg Ser Pro Ser Phe Glu Lys 
                165         


<210>  88
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  88

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro Ala Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  89
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  89

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro Ala Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  90
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  90

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  91
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  91

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  92
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  92

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  93
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  93

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  94
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  94

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  95
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  96
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  96

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  97
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  98
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  98

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 
        115                 120                 125             


Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala Ala Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  99
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  99

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  100
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  100

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  101
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  101

Val His Tyr Gly 
1               


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Asp Ala Ser Pro His Val His Tyr Gly 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Asp Ser Ser Pro Leu Val His Tyr Gly 
1               5                   


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  104

Asp Ser Ser Pro Leu Leu Gln 
1               5           


<210>  105
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  105

Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10          


<210>  106
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  106

Arg His Pro Ile Pro 
1               5   


<210>  107
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  107

His Pro Ile Pro 
1               


<210>  108
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Pro Leu Ala Phe 
1               5   


<210>  109
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  109

Pro Leu Ala Phe 
1               


<210>  110
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Asp Ser Ser Pro Leu 
1               5       


<210>  111
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ser Asp Ser Ser Pro Leu 
1               5           


<210>  112
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  112

Ser Asp Ser Ser Pro Leu 
1               5       


<210>  113
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ser Ser Pro Leu 
1               5   


<210>  114
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  114

Ser Ser Pro Leu 
1               


<210>  115
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  115

Arg Asp Ser Ser 
1               


<210>  116
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Asp Ser Ser 
1               


<210>  117
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Arg Asp Ser Ser 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Ser Ser Pro Leu 
1               5   


<210>  119
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Asp Ser Ser Pro Leu 
1               5       


<210>  120
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ser Asp Ser Ser Pro Leu 
1               5           


<210>  121
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  121

Asp Ser Ser Pro Leu 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  122

Asp Ala Ser Pro His 
1               5   


<210>  123
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  123

Arg Asp Ser Ser 
1               


<210>  124
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Asp Ser Ser 
1               


<210>  125
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Arg Asp Ser Ser 
1               5   


<210>  126
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Asp Ser Ser Pro Leu 
1               5       


<210>  127
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ser Asp Ser Ser Pro Leu 
1               5           


<210>  128
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Ser Pro Leu 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  129

Gly Ser Gly Gly Ser 
1               5   


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  130

Gly Gly Gly Ser 
1               


<210>  131
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  131

Gly Gly Ser Gly 
1               


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  132

Gly Gly Ser Gly Gly 
1               5   


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  133

Gly Ser Gly Ser Gly 
1               5   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  134

Gly Ser Gly Gly Gly 
1               5   


<210>  135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Linker sequence

<400>  135

Gly Ser Ser Ser Gly 
1               5   


<210>  136
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Forward primer

<400>  136
ccgactagtc accatgcgga gcgggtgtgt gg                                     32


<210>  137
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Reverse primer

<400>  137
ataagaatgc ggccgcttac ttctcaaagc tgggactcct c                           41


<210>  138
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  138

Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 
1               5                   10                  15      


Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 
            20                  25                  30          


Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 
        35                  40                  45              


Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly 
    50                  55                  60                  


Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile 
                85                  90                  95      


Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro 
            100                 105                 110         


Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 
        115                 120                 125             


Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 
    130                 135                 140                 


Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 
145                 150                 155                 160 


Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 
                165                 170                 175     


Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185     


<210>  139
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  139

Arg Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  140
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  140

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  141
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  141

Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 
1               5                   10                  15      


Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu 
            20                  25                  30          


Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala 
        35                  40                  45              


His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 
    50                  55                  60                  


Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 
65                  70                  75                  80  


Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu 
                85                  90                  95      


Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg 
            100                 105                 110         


Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn 
        115                 120                 125             


Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val 
    130                 135                 140                 


Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe 
145                 150                 155                 160 


Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 
                165                 170                 175     


Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185             


<210>  142
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  142

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  143
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  143

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  144
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  144

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  145
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  145

Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Trp Gly 
1               5                   10                  15      


Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  146
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  146

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  147
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  147

Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  148
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  148

Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  149
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  149

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
1               5                   10                  15      


Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  150
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  150

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Ala Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  151
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  151

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  152
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  152

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Pro Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  153
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  153

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Ala 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  154
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  154

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Glu 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  155
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  155

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  156
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  156

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Ala Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  157
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  157

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  158
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  158

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Thr Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  159
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  159

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 
1               5                   10                  15      


Gln Pro Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 
            20                  25                  30          


Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 
        35                  40                  45              


Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 
    50                  55                  60                  


Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 
65                  70                  75                  80  


Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 
                85                  90                  95      


Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 
            100                 105                 110         


Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             


Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 


Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 
145                 150                 155                 160 


Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     


Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 
            180                 185                 190         


Lys 
    


<210>  160
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  160

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  161
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  161

Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 
1               5                   10                  15      


Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 
            20                  25                  30          


Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 
        35                  40                  45              


Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly 
    50                  55                  60                  


Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile 
                85                  90                  95      


Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro 
            100                 105                 110         


Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 
        115                 120                 125             


Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 
    130                 135                 140                 


Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 
145                 150                 155                 160 


Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 
                165                 170                 175     


Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185     


<210>  162
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  162

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  163
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  163

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  164
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  164

His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Trp Gly Asp 
1               5                   10                  15      


Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 
            20                  25                  30          


Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 
        35                  40                  45              


Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 
    50                  55                  60                  


Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 
65                  70                  75                  80  


Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 
                85                  90                  95      


Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 
            100                 105                 110         


Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 
        115                 120                 125             


Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 
    130                 135                 140                 


Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 
145                 150                 155                 160 


Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 
                165                 170                 175     


Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190         


<210>  165
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  165

His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln Val 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  166
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  166

Asp Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 
1               5                   10                  15      


Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu 
            20                  25                  30          


Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala 
        35                  40                  45              


His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 
    50                  55                  60                  


Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 
65                  70                  75                  80  


Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu 
                85                  90                  95      


Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg 
            100                 105                 110         


Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn 
        115                 120                 125             


Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val 
    130                 135                 140                 


Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe 
145                 150                 155                 160 


Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 
                165                 170                 175     


Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185             


<210>  167
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  167

Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr 
1               5                   10                  15      


Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp 
            20                  25                  30          


Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu 
        35                  40                  45              


Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser 
    50                  55                  60                  


Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu 
65                  70                  75                  80  


Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp 
                85                  90                  95      


Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu 
            100                 105                 110         


Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro 
        115                 120                 125             


Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu 
    130                 135                 140                 


Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu 
145                 150                 155                 160 


Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val 
                165                 170                 175     


Arg Ser Pro Ser Phe Glu Lys 
            180             


<210>  168
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  168

Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
1               5                   10                  15      


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
            20                  25                  30          


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
        35                  40                  45              


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
    50                  55                  60                  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
65                  70                  75                  80  


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
                85                  90                  95      


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
            100                 105                 110         


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
        115                 120                 125             


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
    130                 135                 140                 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
145                 150                 155                 160 


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
                165                 170                 


<210> 169
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 169
Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly
 1               5                  10                  


<210> 170
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 170
Trp Gly Asp Pro Ile
 1               5  


<210> 171
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 171
Trp Gly Pro Ile
 1              


<210> 172
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 172
Trp Gly Asp Pro Val
 1               5  


<210> 173
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 173
Trp Gly Asp Ile
 1              


<210> 174
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 174
Gly Asp Pro Ile
 1              


<210> 175
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 175
Trp Gly Gln Pro Ile
 1               5  


<210> 176
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 176
Trp Gly Ala Pro Ile
 1               5  


<210> 177
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 177
Ala Gly Asp Pro Ile
 1               5  


<210> 178
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 178
Trp Ala Asp Pro Ile
 1               5  


<210> 179
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 179
Trp Gly Asp Ala Ile
 1               5  


<210> 180
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 180
Trp Gly Asp Pro Ala
 1               5  


<210> 181
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 181
Trp Asp Pro Ile
 1              


<210> 182
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 182
Trp Gly Asp Ile
 1              


<210> 183
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 183
Trp Gly Asp Pro
 1              


<210> 184
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 184
Phe Gly Asp Pro Ile
 1               5  


<210> 185
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 185
Arg Leu Arg His Leu Tyr Thr Ser Gly
 1               5                  


<210> 186
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> core sequence

<400> 186
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp
 1               5                  


<210> 187
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 187
Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile
 1               5                  10              


<210> 188
<211> 165
<212> PRT
<213> Homo sapiens

<220> 
<223> FGF19 C-terminal sequence

<400> 188
Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val
 1               5                  10                  15      
Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
            20                  25                  30          
Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg
        35                  40                  45              
Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
    50                  55                  60                  
Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
65                  70                  75                  80  
Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
                85                  90                  95      
Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
            100                 105                 110         
His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu
        115                 120                 125             
Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp
    130                 135                 140                 
Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
145                 150                 155                 160 
Pro Ser Phe Glu Lys
                165 


<210> 189
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 189
Gly Gly Gly Ser Gly
 1               5  


<210> 190
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Sheet-8/Loop-8/Sheet-9 region of FGF19

<400> 190
Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
 1               5                  10      


<210> 191
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Sheet-8/Loop-8/Sheet-9 region of FGF21

<400> 191
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr
 1               5                  10      


<210> 192
<211> 187
<212> PRT
<213> Artificial Sequence

<220> 
<223> M53 sequence 

<400> 192
Met Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg
 1               5                  10                  15      
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg
            20                  25                  30          
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His
        35                  40                  45              
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
    50                  55                  60                  
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met
65                  70                  75                  80  
Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu
                85                  90                  95      
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu
            100                 105                 110         
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg
        115                 120                 125             
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro
    130                 135                 140                 
Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser
145                 150                 155                 160 
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly
                165                 170                 175     
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys
            180                 185         


<210> 193
<211> 194
<212> PRT
<213> Artificial Sequence

<220> 
<223> M139 sequence

<400> 193
Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
 1               5                  10                  15      
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
            20                  25                  30          
Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
        35                  40                  45              
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
    50                  55                  60                  
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65                  70                  75                  80  
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
                85                  90                  95      
Asp Cys Ala Phe Glu Glu Glu Ile Leu Pro Asp Gly Tyr Asn Val Tyr
            100                 105                 110         
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
        115                 120                 125             
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
    130                 135                 140                 
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
145                 150                 155                 160 
Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
                165                 170                 175     
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
            180                 185                 190         
Glu Lys
        


<210> 194
<211> 194
<212> PRT
<213> Artificial Sequence

<220> 
<223> M140 sequence

<400> 194
Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
 1               5                  10                  15      
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
            20                  25                  30          
Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
        35                  40                  45              
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
    50                  55                  60                  
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65                  70                  75                  80  
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
                85                  90                  95      
Asp Cys Ala Phe Glu Glu Glu Ile Arg Glu Asp Gly Tyr Asn Val Tyr
            100                 105                 110         
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
        115                 120                 125             
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
    130                 135                 140                 
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
145                 150                 155                 160 
Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
                165                 170                 175     
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
            180                 185                 190         
Glu Lys
        


<210> 195
<211> 194
<212> PRT
<213> Artificial Sequence

<220> 
<223> M141 sequence

<400> 195
Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
 1               5                  10                  15      
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
            20                  25                  30          
Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
        35                  40                  45              
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
    50                  55                  60                  
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65                  70                  75                  80  
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
                85                  90                  95      
Asp Cys Ala Phe Glu Glu Glu Ile Leu Cys Asp Gly Tyr Asn Val Tyr
            100                 105                 110         
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
        115                 120                 125             
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
    130                 135                 140                 
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
145                 150                 155                 160 
Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
                165                 170                 175     
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
            180                 185                 190         
Glu Lys
        


<210> 196
<211> 194
<212> PRT
<213> Artificial Sequence

<220> 
<223> M160 sequence

<400> 196
Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
 1               5                  10                  15      
Gly Asp Pro Ile Arg Gln Arg His Leu Tyr Thr Ser Gly Pro His Gly
            20                  25                  30          
Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
        35                  40                  45              
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
    50                  55                  60                  
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65                  70                  75                  80  
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
                85                  90                  95      
Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr
            100                 105                 110         
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
        115                 120                 125             
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
    130                 135                 140                 
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
145                 150                 155                 160 
Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
                165                 170                 175     
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
            180                 185                 190         
Glu Lys



<210>  197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M200 Sequence

<400>  197

Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg 
1               5                   10                  15      


Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 
            20                  25                  30          


Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 
        35                  40                  45              


Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 
    50                  55                  60                  


Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 
                85                  90                  95      


Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 
            100                 105                 110         


Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 
        115                 120                 125             


Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 
    130                 135                 140                 


Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 
145                 150                 155                 160 


Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 
                165                 170                 175     


Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 


<210>  198
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M201 Sequence

<400>  198

Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  199
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M202 Sequence

<400>  199

Arg Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  200
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M203 Sequence

<400>  200

Arg Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  201
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M204 Sequence

<400>  201

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  202
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M205 Sequence

<400>  202

Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 
1               5                   10                  15      


His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
            20                  25                  30          


Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 
        35                  40                  45              


Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
    50                  55                  60                  


Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 
65                  70                  75                  80  


Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 
                85                  90                  95      


Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
            100                 105                 110         


Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 
        115                 120                 125             


Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 
    130                 135                 140                 


Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 
145                 150                 155                 160 


Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 
                165                 170                 175     


Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185         


<210>  203
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M206 Sequence

<400>  203

Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 
            20                  25                  30          


Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 
        35                  40                  45              


Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 
    50                  55                  60                  


Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 
65                  70                  75                  80  


Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 
                85                  90                  95      


Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu 
            100                 105                 110         


Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 
        115                 120                 125             


Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 
    130                 135                 140                 


Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 
145                 150                 155                 160 


Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 
                165                 170                 175     


Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190     


<210>  204
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M207 Sequence

<400>  204

Met Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Sheet-8/Loop-8/Sheet-9 region of FGF19

<400>  205

Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr 
1               5                   10      


<210>  206
<211>  504
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human CYP7A1 (including SNP variants)

<400>  206

Met Met Thr Thr Ser Leu Ile Trp Gly Ile Ala Ile Ala Ala Cys Cys 
1               5                   10                  15      


Cys Leu Trp Leu Ile Leu Gly Ile Arg Arg Arg Gln Thr Gly Glu Pro 
            20                  25                  30          


Pro Leu Glu Asn Gly Leu Ile Pro Tyr Leu Gly Cys Ala Leu Gln Phe 
        35                  40                  45              


Gly Ala Asn Pro Leu Glu Phe Leu Arg Ala Asn Gln Arg Lys His Gly 
    50                  55                  60                  


His Val Phe Thr Cys Lys Leu Met Gly Lys Tyr Val His Phe Ile Thr 
65                  70                  75                  80  


Asn Pro Leu Ser Tyr His Lys Val Leu Cys His Gly Lys Tyr Phe Asp 
                85                  90                  95      


Trp Lys Lys Phe His Phe Ala Thr Ser Ala Lys Ala Phe Gly His Arg 
            100                 105                 110         


Ser Ile Asp Pro Met Asp Gly Asn Thr Thr Glu Asn Ile Asn Asp Thr 
        115                 120                 125             


Phe Ile Lys Thr Leu Gln Gly His Ala Leu Asn Ser Leu Thr Glu Ser 
    130                 135                 140                 


Met Met Glu Asn Leu Gln Arg Ile Met Arg Pro Pro Val Ser Ser Asn 
145                 150                 155                 160 


Ser Lys Thr Ala Ala Trp Val Thr Glu Gly Met Tyr Ser Phe Cys Tyr 
                165                 170                 175     


Arg Val Met Phe Glu Ala Gly Tyr Leu Thr Ile Phe Gly Arg Asp Leu 
            180                 185                 190         


Thr Arg Arg Asp Thr Gln Lys Ala His Ile Leu Asn Asn Leu Asp Asn 
        195                 200                 205             


Phe Lys Gln Phe Asp Lys Val Phe Pro Ala Leu Val Ala Gly Leu Pro 
    210                 215                 220                 


Ile His Met Phe Arg Thr Ala His Asn Ala Arg Glu Lys Leu Ala Glu 
225                 230                 235                 240 


Ser Leu Arg His Glu Asn Leu Gln Lys Arg Glu Ser Ile Ser Glu Leu 
                245                 250                 255     


Ile Ser Leu Arg Met Phe Leu Asn Asp Thr Leu Ser Thr Phe Asp Asp 
            260                 265                 270         


Leu Glu Lys Ala Lys Thr His Leu Val Val Leu Trp Ala Ser Gln Ala 
        275                 280                 285             


Asn Thr Ile Pro Ala Thr Phe Trp Ser Leu Phe Gln Met Ile Arg Asn 
    290                 295                 300                 


Pro Glu Ala Met Lys Ala Ala Thr Glu Glu Val Lys Arg Thr Leu Glu 
305                 310                 315                 320 


Asn Ala Gly Gln Lys Val Ser Leu Glu Gly Asn Pro Ile Cys Leu Ser 
                325                 330                 335     


Gln Ala Glu Leu Asn Asp Leu Pro Val Leu Asp Ser Ile Ile Lys Glu 
            340                 345                 350         


Ser Leu Arg Leu Ser Ser Ala Ser Leu Asn Ile Arg Thr Ala Lys Glu 
        355                 360                 365             


Asp Phe Thr Leu His Leu Glu Asp Gly Ser Tyr Asn Ile Arg Lys Asp 
    370                 375                 380                 


Asp Ile Ile Ala Leu Tyr Pro Gln Leu Met His Leu Asp Pro Glu Ile 
385                 390                 395                 400 


Tyr Pro Asp Pro Leu Thr Phe Lys Tyr Asp Arg Tyr Leu Asp Glu Asn 
                405                 410                 415     


Gly Lys Thr Lys Thr Thr Phe Tyr Cys Asn Gly Leu Lys Leu Lys Tyr 
            420                 425                 430         


Tyr Tyr Met Pro Phe Gly Ser Gly Ala Thr Ile Cys Pro Gly Arg Leu 
        435                 440                 445             


Phe Ala Ile His Glu Ile Lys Gln Phe Leu Ile Leu Met Leu Ser Tyr 
    450                 455                 460                 


Phe Glu Leu Glu Leu Ile Glu Gly Gln Ala Lys Cys Pro Pro Leu Asp 
465                 470                 475                 480 


Gln Ser Arg Ala Gly Leu Gly Ile Leu Pro Pro Leu Asn Asp Ile Glu 
                485                 490                 495     


Phe Lys Tyr Lys Phe Lys His Leu 
            500                 


<210>  207
<211>  4959
<212>  DNA
<213>  Homo sapiens

<220>
<223>   mRNA encoding human CYP7A

<400>  207
gaattcaaga tgagatttgg atggggacac agccaaacca tgtcacacta ccatgcctga       60

cttcctttcc atttttgtat atttgcttgt tcttcatttg cccgagaagt aactctaaag      120

ggctgtatta tttggatatt agattggcat tttatctgac tgggatatct tgctgtgatt      180

gtccatgtat aagatcagct tttctataag ccatattttt aaaaagatat attaattttt      240

taaaaatcca cctgtctaaa taaatgcaca aagcccccca aaaacctaga ttctaagaaa      300

aatctatgta ctgccataca atgattgata ttaatattta tggtgataaa ttacacacaa      360

aaaatgtgtg atctctgttt aaacaggcaa aaacaaaaaa cacatgaaat aaatctatgg      420

catctatagc caaaactgga aacaacccac atatccatca ataggaaatc agttaaataa      480

attatagtac atttatccaa tggaagatta gcacatattc aatataatta tttatacaca      540

catatagata cacacatgta taaatataga gaatactgtg ggtgtatgtg tgtgtgtgtt      600

tatatacata tatatacaca cacagtactg ttgcctacct tcttggctta attctgagaa      660

ctctcattca ctctgcttca gtaggatacc tccttctttt tggttcttag actcaccaag      720

ttgatccttg actcaagaca ttgcatttgc tgcttcctct tcctggaata tccttccttc      780

tgatattcac atgagtagtc tcttcttgtc attcagatct caaatgtcac aatttcagag      840

agcccatctc tgatcatcat atctaaagtt gtcctcattc ccccatagct ttctatacca      900

tgttttattt ttttcataac atgtatttta ttactccttt ctccattgga atagaatctc      960

cattagatta ggaaatctgc ctatcttatt aatgcctgca actggaatac ttttgaagag     1020

ttcttggcac gtaataaata ctcaactaat atttttgtgt acacagaaat aaagtttgga     1080

agaacagatg ccaaattgtt actagtggtt acttctgagt aaaggagtag catggtaggt     1140

aaattattaa tagatgttca ctttccacca agatatgttt tagttagtct taacttactt     1200

gaaatgaaat ttattacttt aataattaga aacattgata aacattttag tcacaagaat     1260

gatagataaa attttgatgc ttccaataag ttatatttat ctagaggatg cacttatgta     1320

gaatactctc ttgaggatgt taggtgagta acatgttact atatgtagta aaatatctat     1380

gattttataa aagcactgaa acatgaagca gcagaaatgt ttttcccagt tctctttcct     1440

ctgaacttga tcaccgtctc tctggcaaag cacctaaatt aattcttctt taaaagttaa     1500

caagaccaaa ttataagctt gatgaataac tcattcttat ctttctttaa atgattatag     1560

tttatgtatt tattagctat gcccatctta aacaggttta tttgttcttt ttacacatac     1620

caaactctta atattagctg ttgtccccag gtccgaatgt taagtcaaca tatatttgag     1680

agaccttcaa cttatcaagt attgcaggtc tctgattgct ttggaaccac ttctgatacc     1740

tgtggactta gttcaaggcc agttactacc actttttttt ttctaataga atgaacaaat     1800

ggctaattgt ttgctttgtc aaccaagctc aagttaatgg atctggatac tatgtatata     1860

aaaagcctag cttgagtctc ttttcagtgg catccttccc tttctaatca gagattttct     1920

tcctcagaga ttttggccta gatttgcaaa atgatgacca catctttgat ttgggggatt     1980

gctatagcag catgctgttg tctatggctt attcttggaa ttaggagaag gtaagtaatg     2040

ttttatcttt aaattgctct ttgattcatc catttaattt ttttaccttc atttttatac     2100

agtaaatttg gttttctata cttacacata ttagcattat cttccttatg ttttaaatga     2160

aaaatttgat ttgaattttt aaagtaatat cttttttact atatctcaca agacatatga     2220

cagcttccct ttttagtatt ggcatatacc gatggtaata tataaatgta tattggtgtt     2280

aaacataact gacagaaatt gtataaggtc tctatgtaca tttatatgtg tatctaaaga     2340

ggaagcccag attagtaagg atacaagtag caagtgggaa tctacaatgg aaaggattgc     2400

tttctctcac atggcttcaa tagatactct tgcttaaata aatgttctct tttaagctca     2460

ttcttgtgca tcgcatagac tcagcctaag cctgaacaag agcatagagc ctgagctgat     2520

cattctatta ctgtttttaa ataaatgtta atcaactgtg gtgaattggg aaagtttgct     2580

gagtgtatgt gacatcgatt tcatttattt acaactggtt caagaatgca agaaaaacaa     2640

atacagtcag atccagaacc atagtttatt taacttctaa ttggctcaag gagtaattgt     2700

ggggaggcat atagatattc tctgctatgt caatctcaaa aagagaaaat aaccctaacc     2760

atctttcagc tttgtagatt gctatgtgtt ttctgccttt gcagtttctt tcaggcctga     2820

tagtttttac ttttaattaa actacttatc ttcaaactaa gaaaagaaag gtaattactt     2880

tatactgtat tattctatca agaggtacag aagtttatgt tggaaaataa gtttacatgt     2940

tctaataaaa acattttaaa ggagcactga attacaatag atgattccgt cagtgtttat     3000

cttactcaat ttcattttat aataagctga tttctcacat gagattcttc ttctctgaaa     3060

ccatccttat agaatataat atagatatct ttaaactagg aatattttca aaacctcagt     3120

tctgaaatcc tcccttattc agtgatctgt gtctttaaag aaaataatca aaagaaacat     3180

tttgagatat ttagaaaaat gatgcttagc aaagtgataa acactagaat gtagttttgt     3240

ttccgcactg acaacaagaa tcttgttggt cttgtaaatc cttttgcctg tatcactggg     3300

aaaagtgatg agcacatagt agacgggtgc ttgttgaatg tgtatatgga cggatgcatg     3360

aatggatgga tttagtaatc ctttccacca acatatcatg ttactaggtt aatataacct     3420

attactgtag taaaagagca gggcccatcc aacaaaagaa atatctataa actatagggt     3480

ttcaaagttt gaagtcagtg ggaaaaattt taaaacctga tgtaagtaaa aacccaaaac     3540

tgtaatcatc catgtctatc atacacttgt gtctgacagg caaacgggtg aaccacctct     3600

agagaatgga ttaattccat acctgggctg tgctctgcaa tttggtgcca atcctcttga     3660

gttcctcaga gcaaatcaaa ggaaacatgg tcatgttttt acctgcaaac taatgggaaa     3720

atatgtccat ttcatcacaa atcccttgtc ataccataag gtgttgtgcc acggaaaata     3780

ttttgattgg aaaaaatttc actttgctac ttctgcgaag gtaagcagtt ttacatttat     3840

ataccattct gtttgtcttc taccttttta tgtgcttgtc tatttagaaa ttttgatgta     3900

cttagatttt atgataaagg tgttgaagag agttatcctt atgtggagat tcttagaaac     3960

ataaataaat tatacgtagc ttcttagtaa taatcattta gaaagtcaaa ataggtatag     4020

atttccgtca tttgctttgc acgagctaat gagggtgaaa tacagattaa atgctctact     4080

gagacaggtg gcactgtacg aataagatag attaaaattc atcacatcag caatgtctat     4140

gcagagcgaa gtgacggaaa cctaacattc agcagttgtc tcaccacact tgtgccacac     4200

agtgtttcat tttgataagg aattggcaag atattttaac atcatttaga tgtaataaaa     4260

gaagatctgt tactgagaaa aaaaaccaat aactacttac ttactgcaaa taaatattag     4320

ctttggtctt tgtgactaag tagcttaaag tttggttaaa atacatctac agctggacac     4380

aatggaacac acctgtagtc cctgctattt gagaggctga ggcaggagga tcgcttgagt     4440

ccaggagttt gaggctgcag tgagctatca ttgtgtcact gcactccagc ctgggtgaca     4500

atgtgagacc ccatctctaa aagaaaaaga aaaagaaatc tacaaataat ataaaagata     4560

actaatgatt ttaaaacatt atcaattagt ttatgtgcaa tagctgtaaa taagtgcagt     4620

agcataagaa ataagacata gatgacttga gtgatccagg ggagtgccac tgaagttggc     4680

tttaaaggaa aggtacagtt tggtcattta tttgtaaagt gctatgaact tgtacaaggg     4740

aaagccaatt tcccgtgttt accaagtaag gaactatgaa agtatctaat ccgtttttca     4800

gtcatttact atgactaggt caggtttaac ttctttttct gcatgtttta tttgctatca     4860

ggcatttggg cacagaagca ttgacccgat ggatggaaat accactgaaa acataaacga     4920

cactttcatc aaaaccctgc agggccatgc cttgaattc                            4959


<210>  208
<211>  1654
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human CYP7A1

<400>  208
tggcatcctt ccctttctaa tcagagattt tcttcctcag agattttggc ctagatttgc       60

aaaatgatga ccacatcttt gatttggggg attgctatag cagcatgctg ttgtctatgg      120

cttattcttg gaattaggag aaggcaaacg ggtgaaccac ctctagagaa tggattaatt      180

ccatacctgg gctgtgctct gcaatttggt gccaatcctc ttgagttcct cagagcaaat      240

caaaggaaac atggtcatgt ttttacctgc aaactaatgg gaaaatatgt ccatttcatc      300

acaaatccct tgtcatacca taaggtgttg tgccacggaa aatattttga ttggaaaaaa      360

tttcactttg ctacttctgc gaaggcattt gggcacagaa gcattgaccc gatggatgga      420

aataccactg aaaacataaa cgacactttc atcaaaaccc tgcagggcca tgccttgaat      480

tccctcacgg aaagcatgat ggaaaacctc caacgtatca tgagacctcc agtctcctct      540

aactcaaaga ccgctgcctg ggtgacagaa gggatgtatt ctttctgcta ccgagtgatg      600

tttgaagctg ggtatttaac tatctttggc agagatctta caaggcggga cacacagaaa      660

gcacatattc taaacaatct tgacaacttc aagcaattcg acaaagtctt tccagccctg      720

gtagcaggcc tccccattca catgttcagg actgcgcaca atgcccggga gaaactggca      780

gagagcttga ggcacgagaa cctccaaaag agggaaagca tctcagaact gatcagcctg      840

cgcatgtttc tcaatgacac tttgtccacc tttgatgatc tggagaaggc caagacacac      900

ctcgtggtcc tctgggcatc gcaagcaaac accattccag cgactttctg gagtttattt      960

caaatgatta ggaacccaga agcaatgaaa gcagctactg aagaagtgaa aagaacatta     1020

gagaatgctg gtcaaaaagt cagcttggaa ggcaatccta tttgtttgag tcaagcagaa     1080

ctgaatgacc tgccagtatt agatagtata atcaaggaat cgctgaggct ttccagtgcc     1140

tccctcaaca tccggacagc taaggaggat ttcactttgc accttgagga cggttcctac     1200

aacatccgaa aagatgacat catagctctt tacccacagt taatgcactt agatccagaa     1260

atctacccag accctttgac ttttaaatat gataggtatc ttgatgaaaa cgggaagaca     1320

aagactacct tctattgtaa tggactcaag ttaaagtatt actacatgcc ctttggatcg     1380

ggagctacaa tatgtcctgg aagattgttc gctatccacg aaatcaagca atttttgatt     1440

ctgatgcttt cttattttga attggagctt atagagggcc aagctaaatg tccacctttg     1500

gaccagtccc gggcaggctt gggcattttg ccgccattga atgatattga atttaaatat     1560

aaattcaagc atttgtgaat acatggctgg aataagagga cactagatga tattacagga     1620

ctgcagaaca ccctcaccac acagtccctt tgga                                 1654
