                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. LTD.
       BAYER, Edward A.
       DAVIDI, Lital
       MORAIS, Sarah
       ARTZI, Lior
       ARFI, Yonathan
 
<120>  ENZYME COMPLEX FOR LIGNOCELLULOSIC MATERIAL DEGRADATION

<130>  70534

<150>  IL 247569
<151>  2016-08-30

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  713
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  1

Met Gly Ser Ser His His His His His His Lys Asn Ala Asp Ser Tyr 
1               5                   10                  15      


Ala Lys Lys Pro His Ile Ser Ala Leu Asn Ala Pro Gln Leu Asp Gln 
            20                  25                  30          


Arg Tyr Lys Asn Glu Phe Thr Ile Gly Ala Ala Val Glu Pro Tyr Gln 
        35                  40                  45              


Leu Gln Asn Glu Lys Asp Val Gln Met Leu Lys Arg His Phe Asn Ser 
    50                  55                  60                  


Ile Val Ala Glu Asn Val Met Lys Pro Ile Ser Ile Gln Pro Glu Glu 
65                  70                  75                  80  


Gly Lys Phe Asn Phe Glu Gln Ala Asp Arg Ile Val Lys Phe Ala Lys 
                85                  90                  95      


Ala Asn Gly Met Asp Ile Arg Phe His Thr Leu Val Trp His Ser Gln 
            100                 105                 110         


Val Pro Gln Trp Phe Phe Leu Asp Lys Glu Gly Lys Pro Met Val Asn 
        115                 120                 125             


Glu Thr Asp Pro Val Lys Arg Glu Gln Asn Lys Gln Leu Leu Leu Lys 
    130                 135                 140                 


Arg Leu Glu Thr His Ile Lys Thr Ile Val Glu Arg Tyr Lys Asp Asp 
145                 150                 155                 160 


Ile Lys Tyr Trp Asp Val Val Asn Glu Val Val Gly Asp Asp Gly Lys 
                165                 170                 175     


Leu Arg Asn Ser Pro Trp Tyr Gln Ile Ala Gly Ile Asp Tyr Ile Lys 
            180                 185                 190         


Val Ala Phe Gln Ala Ala Arg Lys Tyr Gly Gly Asp Asn Ile Lys Leu 
        195                 200                 205             


Tyr Met Asn Asp Tyr Asn Thr Glu Val Glu Pro Lys Arg Thr Ala Leu 
    210                 215                 220                 


Tyr Asn Leu Val Lys Gln Leu Lys Glu Glu Gly Val Pro Ile Asp Gly 
225                 230                 235                 240 


Ile Gly His Gln Ser His Ile Gln Ile Gly Trp Pro Ser Glu Ala Glu 
                245                 250                 255     


Ile Glu Lys Thr Ile Asn Met Phe Ala Ala Leu Gly Leu Asp Asn Gln 
            260                 265                 270         


Ile Thr Glu Leu Asp Val Ser Met Tyr Gly Trp Pro Pro Arg Ala Tyr 
        275                 280                 285             


Pro Thr Tyr Asp Ala Ile Pro Lys Gln Lys Phe Leu Asp Gln Ala Ala 
    290                 295                 300                 


Arg Tyr Asp Arg Leu Phe Lys Leu Tyr Glu Lys Leu Ser Asp Lys Ile 
305                 310                 315                 320 


Ser Asn Val Thr Phe Trp Gly Ile Ala Asp Asn His Thr Trp Leu Asp 
                325                 330                 335     


Ser Arg Ala Asp Val Tyr Tyr Asp Ala Asn Gly Asn Val Val Val Asp 
            340                 345                 350         


Pro Asn Ala Pro Tyr Ala Lys Val Glu Lys Gly Lys Gly Lys Asp Ala 
        355                 360                 365             


Pro Phe Val Phe Gly Pro Asp Tyr Lys Val Lys Pro Ala Tyr Trp Ala 
    370                 375                 380                 


Ile Ile Asp His Lys Ser Ala Gly Glu Asn Leu Tyr Phe Gln Gly Thr 
385                 390                 395                 400 


Ser Pro Val Ile Val Tyr Gly Asp Tyr Asn Asn Asp Gly Asn Val Asp 
                405                 410                 415     


Ala Leu Asp Phe Ala Gly Leu Lys Lys Tyr Ile Met Ala Ala Asp His 
            420                 425                 430         


Ala Tyr Val Lys Asn Leu Asp Val Asn Leu Asp Asn Glu Val Asn Ala 
        435                 440                 445             


Phe Asp Leu Ala Ile Leu Lys Lys Tyr Leu Leu Gly Met Val Ser Lys 
    450                 455                 460                 


Leu Pro Ser Gln Asp Pro Asn Ser Val Thr Gly Thr Val Val Glu Leu 
465                 470                 475                 480 


Ala Pro Gly Ile His Ala Gly Phe Thr Gly Arg Ala Gly Gly Val Ser 
                485                 490                 495     


Gly Glu Pro Tyr Ala Thr Leu Asn Leu Gly Asp His Val Gly Asp Asp 
            500                 505                 510         


Pro Ala Ala Val Ala Glu Asn Arg Arg Arg Ala Ala Leu Gly Phe Gly 
        515                 520                 525             


Ile Ser Pro Asp Arg Val Val Trp Met Asn Gln Val His Gly Ala Thr 
    530                 535                 540                 


Ala Val Thr Val Thr Gly Ser Gly Gln Ala Gly Asp Val Asp Ala Val 
545                 550                 555                 560 


Val Thr Pro Glu Ala Gly Leu Ala Leu Ala Val Leu Val Ala Asp Cys 
                565                 570                 575     


Leu Pro Leu Leu Val Ala Asp Ala Ala Ala Gly Val Ile Gly Ala Ala 
            580                 585                 590         


His Ala Gly Arg Pro Gly Met Ala Ala Gly Val Val Pro Ala Leu Val 
        595                 600                 605             


Ala Glu Met Ala Arg His Gly Ala Arg Pro Glu Arg Cys Val Ala Leu 
    610                 615                 620                 


Leu Gly Pro Ala Ile Cys Gly Arg Cys Tyr Glu Val Pro Arg Asp Leu 
625                 630                 635                 640 


Gln Asp Arg Val Ala Arg Thr Val Pro Glu Ala Arg Cys Thr Thr Ala 
                645                 650                 655     


Glu Gly Thr Pro Gly Leu Asp Ile Arg Ala Gly Val Thr Ala Gln Leu 
            660                 665                 670         


Thr Asn Leu Gly Val Thr Asn Ile Thr His Asp Ser Arg Cys Thr Arg 
        675                 680                 685             


Glu Ser Ala Asp Leu Phe Ser Tyr Arg Arg Asp Ala Thr Thr Gly Arg 
    690                 695                 700                 


Phe Ala Gly Tyr Val Trp Arg Val Pro 
705                 710             


<210>  2
<211>  411
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  2

Met Ala His His His His His His Ala Pro Ser Pro Gly Thr Lys Leu 
1               5                   10                  15      


Val Pro Thr Trp Gly Asp Thr Asn Cys Asp Gly Val Val Asn Val Ala 
            20                  25                  30          


Asp Val Val Val Leu Asn Arg Phe Leu Asn Asp Pro Thr Tyr Ser Asn 
        35                  40                  45              


Ile Thr Asp Gln Gly Lys Val Asn Ala Asp Val Val Asp Pro Gln Asp 
    50                  55                  60                  


Lys Ser Gly Ala Ala Val Asp Pro Ala Gly Val Lys Leu Thr Val Ala 
65                  70                  75                  80  


Asp Ser Glu Ala Ile Leu Lys Ala Ile Val Glu Leu Ile Thr Leu Pro 
                85                  90                  95      


Gln Ala Val Pro Gly Thr Gln Pro Gly Thr Gly Thr Pro Val Glu Arg 
            100                 105                 110         


Tyr Gly Lys Val Gln Val Cys Gly Thr Gln Leu Cys Asp Glu His Gly 
        115                 120                 125             


Asn Pro Val Gln Leu Arg Gly Met Ser Thr His Gly Ile Gln Trp Phe 
    130                 135                 140                 


Asp His Cys Leu Thr Asp Ser Ser Leu Asp Ala Leu Ala Tyr Asp Trp 
145                 150                 155                 160 


Lys Ala Asp Ile Ile Arg Leu Ser Met Tyr Ile Gln Glu Asp Gly Tyr 
                165                 170                 175     


Glu Thr Asn Pro Arg Gly Phe Thr Asp Arg Met His Gln Leu Ile Asp 
            180                 185                 190         


Met Ala Thr Ala Arg Gly Leu Tyr Val Ile Val Asp Trp His Ile Leu 
        195                 200                 205             


Thr Pro Gly Asp Pro His Tyr Asn Leu Asp Arg Ala Lys Thr Phe Phe 
    210                 215                 220                 


Ala Glu Ile Ala Gln Arg His Ala Ser Lys Thr Asn Val Leu Tyr Glu 
225                 230                 235                 240 


Ile Ala Asn Glu Pro Asn Gly Val Ser Trp Ala Ser Ile Lys Ser Tyr 
                245                 250                 255     


Ala Glu Glu Val Ile Pro Val Ile Arg Gln Arg Asp Pro Asp Ser Val 
            260                 265                 270         


Ile Ile Val Gly Thr Arg Gly Trp Ser Ser Leu Gly Val Ser Glu Gly 
        275                 280                 285             


Ser Gly Pro Ala Glu Ile Ala Ala Asn Pro Val Asn Ala Ser Asn Ile 
    290                 295                 300                 


Met Tyr Ala Phe His Phe Tyr Ala Ala Ser His Arg Asp Asn Tyr Leu 
305                 310                 315                 320 


Asn Ala Leu Arg Glu Ala Ser Glu Leu Phe Pro Val Phe Val Thr Glu 
                325                 330                 335     


Phe Gly Thr Glu Thr Tyr Thr Gly Asp Gly Ala Asn Asp Phe Gln Met 
            340                 345                 350         


Ala Asp Arg Tyr Ile Asp Leu Met Ala Glu Arg Lys Ile Gly Trp Thr 
        355                 360                 365             


Lys Trp Asn Tyr Ser Asp Asp Phe Arg Ser Gly Ala Val Phe Gln Pro 
    370                 375                 380                 


Gly Thr Cys Ala Ser Gly Gly Pro Trp Ser Gly Ser Ser Leu Lys Ala 
385                 390                 395                 400 


Ser Gly Gln Trp Val Arg Ser Lys Leu Gln Ser 
                405                 410     


<210>  3
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  3

Met His His His His His His Asp Val Val Ile Thr Ser Asn Gln Thr 
1               5                   10                  15      


Gly Thr His Gly Gly Tyr Asn Phe Glu Tyr Trp Lys Asp Thr Gly Asn 
            20                  25                  30          


Gly Thr Met Val Leu Lys Asp Gly Gly Ala Phe Ser Cys Glu Trp Ser 
        35                  40                  45              


Asn Ile Asn Asn Ile Leu Phe Arg Lys Gly Phe Lys Tyr Asp Glu Thr 
    50                  55                  60                  


Lys Thr His Asp Gln Leu Gly Tyr Ile Thr Val Thr Tyr Ser Cys Asn 
65                  70                  75                  80  


Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Gly Val Tyr Gly Trp Thr Ser 
                85                  90                  95      


Asn Pro Leu Val Glu Tyr Tyr Ile Ile Glu Ser Trp Gly Thr Trp Arg 
            100                 105                 110         


Pro Pro Gly Ala Thr Pro Lys Gly Thr Ile Thr Val Asp Gly Gly Thr 
        115                 120                 125             


Tyr Glu Ile Tyr Glu Thr Thr Arg Val Asn Gln Pro Ser Ile Lys Gly 
    130                 135                 140                 


Thr Ala Thr Phe Gln Gln Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr 
145                 150                 155                 160 


Ser Gly Thr Ile Ser Val Thr Glu His Phe Lys Ala Trp Glu Arg Leu 
                165                 170                 175     


Gly Met Lys Met Gly Lys Met Tyr Glu Val Ala Leu Val Val Glu Gly 
            180                 185                 190         


Tyr Gln Ser Ser Gly Lys Ala Asp Val Thr Ser Met Thr Ile Thr Val 
        195                 200                 205             


Gly Asn Ala Pro Ser Thr Ser Ser Pro Pro Gly Pro Thr Pro Glu Pro 
    210                 215                 220                 


Thr Pro Arg Ser Ala Phe Ser Lys Ile Glu Ala Glu Glu Tyr Asn Ser 
225                 230                 235                 240 


Leu Lys Ser Ser Thr Ile Gln Thr Ile Gly Thr Ser Asp Gly Gly Ser 
                245                 250                 255     


Gly Ile Gly Tyr Ile Glu Ser Gly Asp Tyr Leu Val Phe Asn Lys Ile 
            260                 265                 270         


Asn Phe Gly Asn Gly Ala Asn Ser Phe Lys Ala Arg Val Ala Ser Gly 
        275                 280                 285             


Ala Asp Thr Pro Thr Asn Ile Gln Leu Arg Leu Gly Ser Pro Thr Gly 
    290                 295                 300                 


Thr Leu Ile Gly Thr Leu Thr Val Ala Ser Thr Gly Gly Trp Asn Asn 
305                 310                 315                 320 


Tyr Glu Glu Lys Ser Cys Ser Ile Thr Asn Thr Thr Gly Gln His Asp 
                325                 330                 335     


Leu Tyr Leu Val Phe Ser Gly Pro Val Asn Ile Asp Tyr Phe Ile Phe 
            340                 345                 350         


Asp Ser Lys Gly Val Asn Pro Thr Pro Thr Pro Thr Ser Thr Thr Thr 
        355                 360                 365             


Pro Thr Pro Lys Phe Ile Tyr Gly Asp Val Asp Gly Asn Gly Ser Val 
    370                 375                 380                 


Arg Ile Asn Asp Ala Val Leu Ile Arg Asp Tyr Val Leu Gly Lys Ile 
385                 390                 395                 400 


Asn Glu Phe Pro Tyr Glu Tyr Gly Met Leu Ala Ala Asp Val Asp Gly 
                405                 410                 415     


Asn Gly Ser Ile Lys Ile Asn Asp Ala Val Leu Val Arg Asp Tyr Val 
            420                 425                 430         


Leu Gly Lys Ile Phe Leu Phe Pro Val Glu Glu Lys Glu Glu Leu Glu 
        435                 440                 445             


His His His His His His 
    450                 


<210>  4
<211>  739
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  4

Met Ala His His His His His His Ala Val Glu Ser Ser Ser Thr Gly 
1               5                   10                  15      


Leu Gly Asp Leu Asn Gly Asp Gly Asn Ile Asn Ser Ser Asp Leu Gln 
            20                  25                  30          


Ala Leu Lys Arg His Leu Leu Gly Ile Ser Pro Leu Thr Gly Glu Ala 
        35                  40                  45              


Leu Leu Arg Ala Asp Val Asn Arg Ser Gly Lys Val Asp Ser Thr Asp 
    50                  55                  60                  


Tyr Ser Val Leu Lys Arg Tyr Ile Leu Arg Ile Ile Thr Glu Val Pro 
65                  70                  75                  80  


Gly His Asp Ser Ala Glu Val Thr Val Arg Glu Ile Asp Pro Asn Thr 
                85                  90                  95      


Ser Ser Tyr Asp Gln Ala Phe Leu Glu Gln Tyr Glu Lys Ile Lys Asp 
            100                 105                 110         


Pro Ala Ser Gly Tyr Phe Arg Glu Phe Asn Gly Leu Leu Val Pro Tyr 
        115                 120                 125             


His Ser Val Glu Thr Met Ile Val Glu Ala Pro Asp His Gly His Gln 
    130                 135                 140                 


Thr Thr Ser Glu Ala Phe Ser Tyr Tyr Leu Trp Leu Glu Ala Tyr Tyr 
145                 150                 155                 160 


Gly Arg Val Thr Gly Asp Trp Lys Pro Leu His Asp Ala Trp Glu Ser 
                165                 170                 175     


Met Glu Thr Phe Ile Ile Pro Gly Thr Lys Asp Gln Pro Thr Asn Ser 
            180                 185                 190         


Ala Tyr Asn Pro Asn Ser Pro Ala Thr Tyr Ile Pro Glu Gln Pro Asn 
        195                 200                 205             


Ala Asp Gly Tyr Pro Ser Pro Leu Met Asn Asn Val Pro Val Gly Gln 
    210                 215                 220                 


Asp Pro Leu Ala Gln Glu Leu Ser Ser Thr Tyr Gly Thr Asn Glu Ile 
225                 230                 235                 240 


Tyr Gly Met His Trp Leu Leu Asp Val Asp Asn Val Tyr Gly Phe Gly 
                245                 250                 255     


Phe Cys Gly Asp Gly Thr Asp Asp Ala Pro Ala Tyr Ile Asn Thr Tyr 
            260                 265                 270         


Gln Arg Gly Ala Arg Glu Ser Val Trp Glu Thr Ile Pro His Pro Ser 
        275                 280                 285             


Cys Asp Asp Phe Thr His Gly Gly Pro Asn Gly Tyr Leu Asp Leu Phe 
    290                 295                 300                 


Thr Asp Asp Gln Asn Tyr Ala Lys Gln Trp Arg Tyr Thr Asn Ala Pro 
305                 310                 315                 320 


Asp Ala Asp Ala Arg Ala Val Gln Val Met Phe Trp Ala His Glu Trp 
                325                 330                 335     


Ala Lys Glu Gln Gly Lys Glu Asn Glu Ile Ala Gly Leu Met Asp Lys 
            340                 345                 350         


Ala Ser Lys Met Gly Asp Tyr Leu Arg Tyr Ala Met Phe Asp Lys Tyr 
        355                 360                 365             


Phe Lys Lys Ile Gly Asn Cys Val Gly Ala Thr Ser Cys Pro Gly Gly 
    370                 375                 380                 


Gln Gly Lys Asp Ser Ala His Tyr Leu Leu Ser Trp Tyr Tyr Ser Trp 
385                 390                 395                 400 


Gly Gly Ser Leu Asp Thr Ser Ser Ala Trp Ala Trp Arg Ile Gly Ser 
                405                 410                 415     


Ser Ser Ser His Gln Gly Tyr Gln Asn Val Leu Ala Ala Tyr Ala Leu 
            420                 425                 430         


Ser Gln Val Pro Glu Leu Gln Pro Asp Ser Pro Thr Gly Val Gln Asp 
        435                 440                 445             


Trp Ala Thr Ser Phe Asp Arg Gln Leu Glu Phe Leu Gln Trp Leu Gln 
    450                 455                 460                 


Ser Ala Glu Gly Gly Ile Ala Gly Gly Ala Thr Asn Ser Trp Lys Gly 
465                 470                 475                 480 


Ser Tyr Asp Thr Pro Pro Thr Gly Leu Ser Gln Phe Tyr Gly Met Tyr 
                485                 490                 495     


Tyr Asp Trp Gln Pro Val Trp Asn Asp Pro Pro Ser Asn Asn Trp Phe 
            500                 505                 510         


Gly Phe Gln Val Trp Asn Met Glu Arg Val Ala Gln Leu Tyr Tyr Val 
        515                 520                 525             


Thr Gly Asp Ala Arg Ala Glu Ala Ile Leu Asp Lys Trp Val Pro Trp 
    530                 535                 540                 


Ala Ile Gln His Thr Asp Val Asp Ala Asp Asn Gly Gly Gln Asn Phe 
545                 550                 555                 560 


Gln Val Pro Ser Asp Leu Glu Trp Ser Gly Gln Pro Asp Thr Trp Thr 
                565                 570                 575     


Gly Thr Tyr Thr Gly Asn Pro Asn Leu His Val Gln Val Val Ser Tyr 
            580                 585                 590         


Ser Gln Asp Val Gly Val Thr Ala Ala Leu Ala Lys Thr Leu Met Tyr 
        595                 600                 605             


Tyr Ala Lys Arg Ser Gly Asp Thr Thr Ala Leu Ala Thr Ala Glu Gly 
    610                 615                 620                 


Leu Leu Asp Ala Leu Leu Ala His Arg Asp Ser Ile Gly Ile Ala Thr 
625                 630                 635                 640 


Pro Glu Gln Pro Ser Trp Asp Arg Leu Asp Asp Pro Trp Asp Gly Ser 
                645                 650                 655     


Glu Gly Leu Tyr Val Pro Pro Gly Trp Ser Gly Thr Met Pro Asn Gly 
            660                 665                 670         


Asp Arg Ile Glu Pro Gly Ala Thr Phe Leu Ser Ile Arg Ser Phe Tyr 
        675                 680                 685             


Lys Asn Asp Pro Leu Trp Pro Gln Val Glu Ala His Leu Asn Asp Pro 
    690                 695                 700                 


Gln Asn Val Pro Ala Pro Ile Val Glu Arg His Arg Phe Trp Ala Gln 
705                 710                 715                 720 


Val Glu Ile Ala Thr Ala Phe Ala Ala His Asp Glu Leu Phe Gly Ala 
                725                 730                 735     


Gly Ala Pro 
            


<210>  5
<211>  840
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  5

Met Gly His His His His His His Ala Met Gly Asp Ser Leu Lys Val 
1               5                   10                  15      


Thr Val Gly Thr Ala Asn Gly Lys Pro Gly Asp Thr Val Thr Val Pro 
            20                  25                  30          


Val Thr Phe Ala Asp Val Ala Lys Met Lys Asn Val Gly Thr Cys Asn 
        35                  40                  45              


Phe Tyr Leu Gly Tyr Asp Ala Ser Leu Leu Glu Val Val Ser Val Asp 
    50                  55                  60                  


Ala Gly Pro Ile Val Lys Asn Ala Ala Val Asn Phe Ser Ser Ser Ala 
65                  70                  75                  80  


Ser Asn Gly Thr Ile Ser Phe Leu Phe Leu Asp Asn Thr Ile Thr Asp 
                85                  90                  95      


Glu Leu Ile Thr Ala Asp Gly Val Phe Ala Asn Ile Lys Phe Lys Leu 
            100                 105                 110         


Lys Ser Val Thr Ala Lys Thr Thr Thr Pro Val Thr Phe Lys Asp Gly 
        115                 120                 125             


Gly Ala Phe Gly Asp Gly Thr Met Ser Lys Ile Ala Ser Val Thr Lys 
    130                 135                 140                 


Thr Asn Gly Ser Val Thr Ile Asp Pro Thr Lys Gly Ala Thr Pro Thr 
145                 150                 155                 160 


Asn Thr Ala Thr Pro Thr Lys Ser Ala Thr Ala Thr Pro Thr Arg Pro 
                165                 170                 175     


Ser Val Pro Arg Pro His Leu Gln Val Asp Ile Gly Ser Thr Ser Gly 
            180                 185                 190         


Lys Ala Gly Ser Val Val Ser Val Pro Ile Thr Phe Thr Asn Val Pro 
        195                 200                 205             


Lys Ser Gly Ile Tyr Ala Leu Ser Phe Arg Thr Asn Phe Asp Pro Gln 
    210                 215                 220                 


Lys Val Thr Val Ala Ser Ile Asp Ala Gly Ser Leu Ile Glu Asn Ala 
225                 230                 235                 240 


Ser Asp Phe Thr Thr Tyr Tyr Asn Asn Glu Asn Gly Phe Ala Ser Met 
                245                 250                 255     


Thr Phe Glu Ala Pro Val Asp Arg Ala Arg Ile Ile Asp Ser Asp Gly 
            260                 265                 270         


Val Phe Ala Thr Ile Asn Phe Lys Val Ser Asp Ser Ala Lys Val Gly 
        275                 280                 285             


Glu Leu Tyr Asn Ile Thr Thr Asn Ser Ala Tyr Thr Ser Phe Tyr Tyr 
    290                 295                 300                 


Ser Gly Thr Asp Glu Ile Lys Asn Val Val Tyr Asn Asp Gly Lys Ile 
305                 310                 315                 320 


Glu Val Ile Ala Ser Val Pro Thr Asn Thr Pro Thr Asn Thr Pro Ala 
                325                 330                 335     


Asn Thr Pro Val Ser Gly Asn Leu Lys Val Glu Phe Tyr Asn Ser Asn 
            340                 345                 350         


Pro Ser Asp Thr Thr Asn Ser Ile Asn Pro Gln Phe Lys Val Thr Asn 
        355                 360                 365             


Thr Gly Ser Ser Ala Ile Asp Leu Ser Lys Leu Thr Leu Arg Tyr Tyr 
    370                 375                 380                 


Tyr Thr Val Asp Gly Gln Lys Asp Gln Thr Phe Trp Cys Asp His Ala 
385                 390                 395                 400 


Ala Ile Ile Gly Ser Asn Gly Ser Tyr Asn Gly Ile Thr Ser Asn Val 
                405                 410                 415     


Lys Gly Thr Phe Val Lys Met Ser Ser Ser Thr Asn Asn Ala Asp Thr 
            420                 425                 430         


Tyr Leu Glu Ile Ser Phe Thr Gly Gly Thr Leu Glu Pro Gly Ala His 
        435                 440                 445             


Val Gln Ile Gln Gly Arg Phe Ala Lys Asn Asp Trp Ser Asn Tyr Thr 
    450                 455                 460                 


Gln Ser Asn Asp Tyr Ser Phe Lys Ser Ala Ser Gln Phe Val Glu Trp 
465                 470                 475                 480 


Asp Gln Val Thr Ala Tyr Leu Asn Gly Val Leu Val Trp Gly Lys Glu 
                485                 490                 495     


Pro Gly Gly Ser Val Val Pro Ser Thr Gln Pro Val Thr Thr Pro Pro 
            500                 505                 510         


Ala Thr Thr Lys Pro Pro Ala Thr Thr Lys Pro Pro Ala Thr Thr Ile 
        515                 520                 525             


Pro Pro Ser Asp Asp Pro Asn Ala Ile Lys Ile Lys Val Asp Thr Val 
    530                 535                 540                 


Asn Ala Lys Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly 
545                 550                 555                 560 


Ile Pro Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp 
                565                 570                 575     


Pro Asn Val Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val 
            580                 585                 590         


Asp Pro Asn Pro Asp Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg 
        595                 600                 605             


Lys Ile Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr 
    610                 615                 620                 


Ala Ile Thr Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys 
625                 630                 635                 640 


Ser Gly Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly 
                645                 650                 655     


Gly Phe Ala Asn Asn Asp Leu Val Glu Gln Arg Thr Gln Phe Phe Asp 
            660                 665                 670         


Gly Gly Val Asn Val Gly Asp Ile Gly Ser Ala Gly Gly Leu Ser Ala 
        675                 680                 685             


Val Gln Pro Asn Val Ser Leu Gly Glu Val Leu Asp Val Ser Ala Asn 
    690                 695                 700                 


Arg Thr Ala Ala Asp Gly Thr Val Glu Trp Leu Ile Pro Thr Val Thr 
705                 710                 715                 720 


Ala Ala Pro Gly Gln Thr Val Thr Met Pro Val Val Val Lys Ser Ser 
                725                 730                 735     


Ser Leu Ala Val Ala Gly Ala Gln Phe Lys Ile Gln Ala Ala Thr Gly 
            740                 745                 750         


Val Arg Tyr Ser Ser Lys Thr Asp Gly Asp Ala Tyr Gly Ser Gly Ile 
        755                 760                 765             


Val Tyr Asn Asn Ser Lys Tyr Ala Phe Gly Gln Gly Ala Gly Arg Gly 
    770                 775                 780                 


Ile Val Ala Ala Asp Asp Ser Val Val Leu Thr Leu Ala Tyr Thr Val 
785                 790                 795                 800 


Pro Ala Asp Cys Ala Glu Gly Thr Tyr Asp Val Lys Trp Ser Asp Ala 
                805                 810                 815     


Phe Val Ser Asp Thr Asp Gly Gln Asn Ile Thr Ser Lys Val Thr Leu 
            820                 825                 830         


Thr Asp Gly Ala Ile Ile Val Lys 
        835                 840 


<210>  6
<211>  324
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  6

Met Gly Ser Ser His His His His His His Thr Ser Pro Val Ile Val 
1               5                   10                  15      


Tyr Gly Asp Tyr Asn Asn Asp Gly Asn Val Asp Ala Leu Asp Phe Ala 
            20                  25                  30          


Gly Leu Lys Lys Tyr Ile Met Ala Ala Asp His Ala Tyr Val Lys Asn 
        35                  40                  45              


Leu Asp Val Asn Leu Asp Asn Glu Val Asn Ala Phe Asp Leu Ala Ile 
    50                  55                  60                  


Leu Lys Lys Tyr Leu Leu Gly Met Val Ser Lys Leu Pro Ser Gln Asp 
65                  70                  75                  80  


Pro Asn Ser Val Thr Gly Thr Val Val Glu Leu Ala Pro Gly Ile His 
                85                  90                  95      


Ala Gly Phe Thr Gly Arg Ala Gly Gly Val Ser Gly Glu Pro Tyr Ala 
            100                 105                 110         


Thr Leu Asn Leu Gly Asp His Val Gly Asp Asp Pro Ala Ala Val Ala 
        115                 120                 125             


Glu Asn Arg Arg Arg Ala Ala Leu Gly Phe Gly Ile Ser Pro Asp Arg 
    130                 135                 140                 


Val Val Trp Met Asn Gln Val His Gly Ala Thr Ala Val Thr Val Thr 
145                 150                 155                 160 


Gly Ser Gly Gln Ala Gly Asp Val Asp Ala Val Val Thr Pro Glu Ala 
                165                 170                 175     


Gly Leu Ala Leu Ala Val Leu Val Ala Asp Cys Leu Pro Leu Leu Val 
            180                 185                 190         


Ala Asp Ala Ala Ala Gly Val Ile Gly Ala Ala His Ala Gly Arg Pro 
        195                 200                 205             


Gly Met Ala Ala Gly Val Val Pro Ala Leu Val Ala Glu Met Ala Arg 
    210                 215                 220                 


His Gly Ala Arg Pro Glu Arg Cys Val Ala Leu Leu Gly Pro Ala Ile 
225                 230                 235                 240 


Cys Gly Arg Cys Tyr Glu Val Pro Arg Asp Leu Gln Asp Arg Val Ala 
                245                 250                 255     


Arg Thr Val Pro Glu Ala Arg Cys Thr Thr Ala Glu Gly Thr Pro Gly 
            260                 265                 270         


Leu Asp Ile Arg Ala Gly Val Thr Ala Gln Leu Thr Asn Leu Gly Val 
        275                 280                 285             


Thr Asn Ile Thr His Asp Ser Arg Cys Thr Arg Glu Ser Ala Asp Leu 
    290                 295                 300                 


Phe Ser Tyr Arg Arg Asp Ala Thr Thr Gly Arg Phe Ala Gly Tyr Val 
305                 310                 315                 320 


Trp Arg Val Pro 
                


<210>  7
<211>  705
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  7

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Thr 
        355                 360                 365             


Ser Gly Ser Gly Ser Ala Gly Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
    370                 375                 380                 


Ser His His His His His His Thr Ser Pro Val Ile Val Tyr Gly Asp 
385                 390                 395                 400 


Tyr Asn Asn Asp Gly Asn Val Asp Ala Leu Asp Phe Ala Gly Leu Lys 
                405                 410                 415     


Lys Tyr Ile Met Ala Ala Asp His Ala Tyr Val Lys Asn Leu Asp Val 
            420                 425                 430         


Asn Leu Asp Asn Glu Val Asn Ala Phe Asp Leu Ala Ile Leu Lys Lys 
        435                 440                 445             


Tyr Leu Leu Gly Met Val Ser Lys Leu Pro Ser Gln Asp Pro Asn Ser 
    450                 455                 460                 


Val Thr Gly Thr Val Val Glu Leu Ala Pro Gly Ile His Ala Gly Phe 
465                 470                 475                 480 


Thr Gly Arg Ala Gly Gly Val Ser Gly Glu Pro Tyr Ala Thr Leu Asn 
                485                 490                 495     


Leu Gly Asp His Val Gly Asp Asp Pro Ala Ala Val Ala Glu Asn Arg 
            500                 505                 510         


Arg Arg Ala Ala Leu Gly Phe Gly Ile Ser Pro Asp Arg Val Val Trp 
        515                 520                 525             


Met Asn Gln Val His Gly Ala Thr Ala Val Thr Val Thr Gly Ser Gly 
    530                 535                 540                 


Gln Ala Gly Asp Val Asp Ala Val Val Thr Pro Glu Ala Gly Leu Ala 
545                 550                 555                 560 


Leu Ala Val Leu Val Ala Asp Cys Leu Pro Leu Leu Val Ala Asp Ala 
                565                 570                 575     


Ala Ala Gly Val Ile Gly Ala Ala His Ala Gly Arg Pro Gly Met Ala 
            580                 585                 590         


Ala Gly Val Val Pro Ala Leu Val Ala Glu Met Ala Arg His Gly Ala 
        595                 600                 605             


Arg Pro Glu Arg Cys Val Ala Leu Leu Gly Pro Ala Ile Cys Gly Arg 
    610                 615                 620                 


Cys Tyr Glu Val Pro Arg Asp Leu Gln Asp Arg Val Ala Arg Thr Val 
625                 630                 635                 640 


Pro Glu Ala Arg Cys Thr Thr Ala Glu Gly Thr Pro Gly Leu Asp Ile 
                645                 650                 655     


Arg Ala Gly Val Thr Ala Gln Leu Thr Asn Leu Gly Val Thr Asn Ile 
            660                 665                 670         


Thr His Asp Ser Arg Cys Thr Arg Glu Ser Ala Asp Leu Phe Ser Tyr 
        675                 680                 685             


Arg Arg Asp Ala Thr Thr Gly Arg Phe Ala Gly Tyr Val Trp Arg Val 
    690                 695                 700                 


Pro 
705 


<210>  8
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
ggtggtctcg agttattctt ctttctcttc aa                                     32


<210>  9
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
tatcgggtac cgcggccgca tttacaggtt gacattggaa gt                          42


<210>  10
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
tacgtggtac cgatgcaatt acctcaattt t                                      31


<210>  11
<211>  2142
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  11
atgggcagca gccatcacca tcatcaccac aagaatgcag attcctatgc gaaaaaacct       60

cacatcagcg cattgaatgc cccacaattg gatcaacgct acaaaaacga gttcacgatt      120

ggtgcggcag tagaacctta tcaactacaa aatgaaaaag acgtacaaat gctaaagcgc      180

cacttcaaca gcattgttgc cgagaacgta atgaaaccga tcagcattca acctgaggaa      240

ggaaaattca attttgaaca agcggatcga attgtgaagt tcgctaaggc aaatggcatg      300

gatattcgct tccatacact cgtttggcac agccaagtac ctcaatggtt ctttcttgac      360

aaggaaggta agccaatggt taatgaaaca gatccagtga aacgtgaaca aaataaacaa      420

ctgctgttaa aacgacttga aactcatatt aaaacgatcg tcgagcggta caaagatgac      480

attaagtact gggacgttgt aaatgaggtt gtgggggacg acggaaaact gcgcaactct      540

ccatggtatc aaatcgccgg catcgattat attaaagtgg cattccaagc agctagaaaa      600

tatggcggag acaacattaa gctttacatg aatgattaca atacagaagt cgaaccgaag      660

cgaaccgctc tttacaattt agtcaaacaa ctgaaagaag agggtgttcc gatcgacggc      720

atcggccatc aatcccacat ccaaatcggc tggccttctg aagcagaaat cgagaaaacg      780

attaacatgt tcgccgctct cggtttagac aaccaaatca ctgagcttga tgtgagcatg      840

tacggttggc cgccgcgcgc ttacccgacg tatgacgcca ttccaaaaca aaagtttttg      900

gatcaggcag cgcgctatga tcgtttgttc aaactgtatg aaaagttgag cgataaaatt      960

agcaacgtca ccttctgggg catcgccgac aatcatacgt ggctcgacag ccgtgcggat     1020

gtgtactatg acgccaacgg gaatgttgtg gttgacccga acgctccgta cgcaaaagtg     1080

gaaaaaggga aaggaaaaga tgcgccgttc gtttttggac cggattacaa agtcaaaccc     1140

gcatattggg ctattatcga ccacaaatcc gcgggtgaaa acctgtactt ccagggtact     1200

agtcctgtaa ttgtatatgg agattataac aatgatggaa atgttgatgc acttgatttt     1260

gcaggcttaa agaaatatat tatggctgct gaccatgctt atgtaaagaa tttggatgtt     1320

aatctcgaca atgaagtgaa tgcatttgac cttgctattt tgaaaaaata tctgcttggt     1380

atggtaagta agctacctag ccaggatccg aattcagtga cgggcaccgt ggtcgagttg     1440

gcccccggga tacacgccgg attcaccggc cgtgccggag gagtcagcgg ggagccgtac     1500

gcgaccctga acctgggcga ccacgtgggt gacgaccctg cagcggtggc ggagaaccgg     1560

agacgggccg ccctcgggtt cgggatctcc cccgaccgcg tggtgtggat gaaccaggtg     1620

cacggcgcca ccgcggtgac cgtgaccgga tccggccagg cgggggacgt cgacgcagtc     1680

gtcaccccgg aagcaggcct cgccttggcg gtgctggtgg cggactgcct gcccctgctg     1740

gtcgcggacg ccgcagccgg ggtgatcggc gcggcgcacg cgggacgccc gggcatggcg     1800

gcgggagtgg tgcctgccct ggtggcggag atggcccggc acggggcgcg ccccgagcgg     1860

tgtgttgccc tcctggggcc cgcgatctgc ggccgctgct acgaggtgcc ccgcgacctg     1920

caggacaggg tggcccgcac ggttccagaa gcccgctgca caaccgcgga aggcacacca     1980

ggactagaca ttcgagccgg agtcaccgca cagttgacga acttgggcgt gacgaatatc     2040

actcatgaca gtcggtgtac tcgggagagc gccgacttgt tctcctaccg cagagacgcg     2100

accaccggac ggttcgccgg atatgtctgg agggtcccat ga                        2142


<210>  12
<211>  1242
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  12
atggcacacc atcaccatca ccatgcacca tcacccggca caaagctcgt tcctacatgg       60

ggcgatacaa actgcgacgg cgttgtaaat gttgctgacg tagtagttct taacagattc      120

ctcaacgatc ctacatattc taacattact gatcagggta aggttaacgc agacgttgtt      180

gatcctcagg ataagtccgg cgcagcagtt gatcctgcag gcgtaaagct cacagtagct      240

gactctgagg caatcctcaa ggctatcgtt gaactcatca cacttcctca agcggtaccc      300

ggcacgcagc ccggcaccgg caccccggtc gagcggtacg gcaaagtcca ggtctgcggc      360

acccagctct gcgacgagca cggcaacccg gtccaactgc gcggcatgag cacccacggc      420

atccagtggt tcgaccactg cctgaccgac agctcgctgg acgccctggc ctacgactgg      480

aaggccgaca tcatccgcct gtccatgtac atccaggaag acggctacga gaccaacccg      540

cgcggcttca ccgaccggat gcaccagctc atcgacatgg ccacggcgcg cggcctgtac      600

gtgatcgtgg actggcacat cctcaccccg ggcgatcccc actacaacct ggaccgggcc      660

aagaccttct tcgcggaaat cgcccagcgc cacgccagca agaccaacgt gctctacgag      720

atcgccaacg aacccaacgg agtgagctgg gcctccatca agagctacgc cgaagaggtc      780

atcccggtga tccgccagcg cgaccccgac tcggtgatca tcgtgggcac ccgcggctgg      840

tcgtcgctcg gcgtctccga aggctccggc cccgccgaga tcgcggccaa cccggtcaac      900

gcctccaaca tcatgtacgc cttccacttc tacgcggcct cgcaccgcga caactacctc      960

aacgcgctgc gtgaggcctc cgagctgttc ccggtcttcg tcaccgagtt cggcaccgag     1020

acctacaccg gtgacggcgc caacgacttc cagatggccg accgctacat cgacctgatg     1080

gcggaacgga agatcgggtg gaccaagtgg aactactcgg acgacttccg ttccggcgcg     1140

gtcttccagc cgggcacctg cgcgtccggc ggcccgtgga gcggttcgtc gctgaaggcg     1200

tccggacagt gggtgcggag caagctccag tcctgactcg ag                        1242


<210>  13
<211>  1365
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  13
atgcaccatc accatcacca cgatgtagta attacgtcaa accagacggg tactcacggc       60

gggtacaact ttgagtactg gaaagacacc ggaaacggaa ccatggtcct caaagacggt      120

ggtgcgttca gctgcgaatg gagcaatatc aacaatattc ttttccgtaa aggtttcaaa      180

tacgatgaaa caaagacaca tgatcaactt ggatacataa cggtaactta ttcctgcaac      240

tatcagccaa acggaaactc ttatctggga gtctacggat ggaccagcaa tccgcttgta      300

gagtattaca tcatcgagag ctggggaacc tggagaccac cgggagcaac accaaagggc      360

actattaccg ttgacggtgg tacatacgag atatacgaga ccaccagagt taaccagcct      420

tccatcaaag gtacagctac tttccagcaa tactggagtg tacgtacatc aaaacgtaca      480

agcggaacca tatccgtaac cgaacacttt aaagcctggg aacgtctggg tatgaaaatg      540

ggaaaaatgt atgaggttgc tttggttgta gaaggatacc agagcagcgg aaaagccgac      600

gtaaccagca tgacaattac tgttggcaac gcaccgtcaa catcatcacc accgggtccg      660

acacctgaac cgactccaag aagtgctttt tcaaaaatcg aagctgagga gtacaactcc      720

ctcaagtcat caaccattca gaccataggc acttccgacg gaggaagcgg tataggttat      780

attgaaagcg gtgactatct ggtatttaac aaaataaact ttggaaacgg tgcaaactct      840

ttcaaggcaa gggttgcatc cggtgcggac acacccacca atatccagtt aagactcgga      900

agcccgaccg gtactcttat aggaactctt acggtggctt ccacaggcgg ttggaacaat      960

tacgaggaaa aatcctgcag cataaccaac actacaggac agcacgactt atatctggta     1020

ttctcaggtc ctgttaacat tgactacttc atattcgact cgaaaggtgt aaatcctaca     1080

cctacaccta ctagtactac aacaccaacg cctaaattta tatatggtga tgttgatggt     1140

aatggaagtg taagaattaa tgatgctgtc ctaataagag actatgtatt aggaaaaatc     1200

aatgaattcc catatgaata tggtatgctt gcagcagatg ttgatggtaa tggaagtata     1260

aaaattaatg atgctgttct agtaagagac tacgtgttag gaaagatatt tttattccct     1320

gttgaagaga aagaagaact cgagcaccac caccaccacc actga                     1365


<210>  14
<211>  2220
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  14
atggcacatc accatcacca tcacgcagtt gaaagcagtt ccacaggtct gggggattta       60

aatggtgacg gaaatattaa ctcgtcggac cttcaggcgt taaagaggca tttgctcggt      120

atatcaccgc ttacgggaga ggctctttta agagcggatg taaataggag cggcaaagtg      180

gattctactg actattcagt gctgaaaaga tatatactcc gcattattac agaggtaccc      240

ggccacgact cggccgaggt gacggtccgg gagatcgacc cgaacaccag ctcctacgac      300

caggccttcc tggagcagta cgagaagatc aaggaccccg ccagcggcta cttccgcgaa      360

ttcaacgggc tcctggtccc ctaccactcg gtggagacca tgatcgtcga ggctccggac      420

cacggccacc agaccacgtc cgaggcgttc agctactacc tgtggctgga ggcgtactac      480

ggccgggtca ccggtgactg gaagccgctc cacgacgcct gggagtcgat ggagaccttc      540

atcatccccg gcaccaagga ccagccgacc aactccgcct acaacccgaa ctccccggcg      600

acctacatcc ccgagcagcc caacgctgac ggctacccgt cgcctctcat gaacaacgtc      660

ccggtgggtc aagacccgct cgcccaggag ctgagctcca cctacgggac caacgagatc      720

tacggcatgc actggctgct cgacgtggac aacgtctacg gcttcgggtt ctgcggcgac      780

ggcaccgacg acgcccccgc ctacatcaac acctaccagc gtggtgcgcg cgagtcggtg      840

tgggagacca ttccgcaccc gtcctgcgac gacttcacgc acggcggccc caacggctac      900

ctggacctgt tcaccgacga ccagaactac gccaagcagt ggcgctacac caacgccccc      960

gacgctgacg cgcgggccgt ccaggtgatg ttctgggcgc acgaatgggc caaggagcag     1020

ggcaaggaga acgagatcgc gggcctgatg gacaaggcgt ccaagatggg cgactacctc     1080

cggtacgcga tgttcgacaa gtacttcaag aagatcggca actgcgtcgg cgccacctcc     1140

tgcccgggtg gccaaggcaa ggacagcgcg cactacctgc tgtcctggta ctactcctgg     1200

ggcggctcgc tcgacacctc ctctgcgtgg gcgtggcgta tcggctccag ctcctcgcac     1260

cagggctacc agaacgtgct cgctgcctac gcgctctcgc aggtgcccga actgcagcct     1320

gactccccga ccggtgtcca ggactgggcc accagcttcg accgccagtt ggagttcctc     1380

cagtggctgc agtccgctga aggtggtatc gccggtggcg ccaccaacag ctggaaggga     1440

agctacgaca ccccgccgac cggcctgtcg cagttctacg gcatgtacta cgactggcag     1500

ccggtctgga acgacccgcc gtccaacaac tggttcggct tccaggtctg gaacatggag     1560

cgcgtcgccc agctctacta cgtgaccggc gacgcccggg ccgaggccat cctcgacaag     1620

tgggtgccgt gggccatcca gcacaccgac gtggacgccg acaacggcgg ccagaacttc     1680

caggtcccct ccgacctgga gtggtcgggc cagcctgaca cctggaccgg cacctacacc     1740

ggcaacccga acctgcacgt ccaggtcgtc tcctacagcc aggacgtcgg tgtgaccgcc     1800

gctctggcca agaccctgat gtactacgcg aagcgttcgg gcgacaccac cgccctcgcc     1860

accgcggagg gtctgctgga cgccctgctg gcccaccggg acagcatcgg tatcgccacc     1920

cccgagcagc cgagctggga ccgtctggac gacccgtggg acggctccga gggcctgtac     1980

gtgccgccgg gctggtcggg caccatgccc aacggtgacc gcatcgagcc gggcgcgacc     2040

ttcctgtcca tccgctcgtt ctacaagaac gacccgctgt ggccgcaggt cgaggcacac     2100

ctgaacgacc cgcagaacgt cccggcgccg atcgtggagc gccaccgctt ctgggctcag     2160

gtggaaatcg cgaccgcgtt cgcagcccac gacgaactgt tcggggccgg agctccctga     2220


<210>  15
<211>  2526
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  15
atgggtcatc accatcacca tcacgccatg ggcgattctc ttaaagttac agtaggaaca       60

gctaatggta agcctggcga tacagtaaca gttcctgtta catttgctga tgtagcaaag      120

atgaaaaacg taggaacatg taatttctat cttggatatg atgcaagcct gttagaggta      180

gtatcagtag atgcaggtcc aatagttaag aatgcagcag ttaacttctc aagcagtgca      240

agcaacggaa caatcagctt cctgttcttg gataacacaa ttacagacga attgataact      300

gcagacggtg tgtttgcaaa tattaagttc aaattaaaga gtgtaacggc taaaactaca      360

acaccagtaa catttaaaga tggtggagct tttggtgacg gaactatgtc aaagatagct      420

tcagttacta agacaaacgg tagtgtaacg atcgatccga ccaagggagc aacaccaaca      480

aatacagcta cgccgacaaa atcagctacg gctacgccca ccaggccatc ggtaccgcgg      540

ccgcatttac aggttgacat tggaagtact agtggaaaag caggtagtgt tgttagtgta      600

cctataacat ttactaatgt acctaaatca ggtatctatg ctctaagttt tagaacaaat      660

ttcgacccac aaaaggtaac tgtagcaagt atagatgctg gctcactgat tgaaaatgct      720

tctgatttta ctacttatta taataatgaa aatggttttg catcaatgac gtttgaagcc      780

ccagttgata gagctagaat catagatagt gatggtgtat ttgcaaccat taactttaaa      840

gttagtgata gtgccaaagt aggtgaactt tacaatatta ctactaatag tgcatatact      900

tcattctatt attctggaac tgatgaaatc aaaaatgttg tttacaatga tggaaaaatt      960

gaggtaattg catcggtacc gacaaacaca ccgacaaaca caccggcaaa tacaccggta     1020

tcaggcaatt tgaaggttga attctacaac agcaatcctt cagatactac taactcaatc     1080

aatcctcagt tcaaggttac taataccgga agcagtgcaa ttgatttgtc caaactcaca     1140

ttgagatatt attatacagt agacggacag aaagatcaga ccttctggtg tgaccatgct     1200

gcaataatcg gcagtaacgg cagctacaac ggaattactt caaatgtaaa aggaacattt     1260

gtaaaaatga gttcctcaac aaataacgca gacacctacc ttgaaataag ctttacaggc     1320

ggaactcttg aaccgggtgc acatgttcag atacaaggta gatttgcaaa gaatgactgg     1380

agtaactata cacagtcaaa tgactactca ttcaagtctg cttcacagtt tgttgaatgg     1440

gatcaggtaa cagcatactt gaacggtgtt cttgtatggg gtaaagaacc cggtggcagt     1500

gtagtaccat caacacagcc tgtaacaaca ccacctgcaa caacaaaacc acctgcaaca     1560

acaaaaccac ctgcaacaac aataccgccg tcagatgatc cgaatgcaat aaagattaag     1620

gtggacacag taaatgcaaa accgggagac acagtaaata tacctgtaag attcagtggt     1680

ataccatcca agggaatagc aaactgtgac tttgtataca gctatgaccc gaatgtactt     1740

gagataatag agataaaacc gggagaattg atagttgacc cgaatcctga caagagcttt     1800

gatactgcag tatatcctga cagaaagata atagtattcc tgtttgcaga agacagcgga     1860

acaggagcgt atgcaataac taaagacgga gtatttgcta cgatagtagc gaaagtaaaa     1920

tccggagcac ctaacggact cagtgtaatc aaatttgtag aagtaggcgg atttgcgaac     1980

aatgaccttg tagaacagag gacacagttc tttgacggtg gagtaaatgt tggagatata     2040

ggatccgccg gtggtttatc cgctgtgcag cctaatgtta gtttaggcga agtactggat     2100

gtttctgcta acagaaccgc tgctgacgga acagttgaat ggcttatccc aacagtaact     2160

gcagctccag gccagacggt cactatgccc gtagtagtca agagttcaag tcttgcagtt     2220

gctggtgcgc agttcaagat ccaggcggcg acaggcgtac gttattcgtc caagacggac     2280

ggtgacgctt acggttcagg cattgtgtac aataatagta agtatgcttt tggacagggt     2340

gcaggtagag gaatagttgc agctgatgat tcggttgtgc ttactcttgc atatacagtt     2400

cccgctgatt gtgctgaagg tacatatgat gtcaagtggt ctgatgcgtt tgtaagtgat     2460

acagacggac agaatatcac aagtaaggtt actcttactg atggcgctat cattgttaag     2520

taggat                                                                2526


<210>  16
<211>  975
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  16
atgggcagca gccatcacca tcatcaccac actagtcctg taattgtata tggagattat       60

aacaatgatg gaaatgttga tgcacttgat tttgcaggct taaagaaata tattatggct      120

gctgaccatg cttatgtaaa gaatttggat gttaatctcg acaatgaagt gaatgcattt      180

gaccttgcta ttttgaaaaa atatctgctt ggtatggtaa gtaagctacc tagccaggat      240

ccgaattcag tgacgggcac cgtggtcgag ttggcccccg ggatacacgc cggattcacc      300

ggccgtgccg gaggagtcag cggggagccg tacgcgaccc tgaacctggg cgaccacgtg      360

ggtgacgacc ctgcagcggt ggcggagaac cggagacggg ccgccctcgg gttcgggatc      420

tcccccgacc gcgtggtgtg gatgaaccag gtgcacggcg ccaccgcggt gaccgtgacc      480

ggatccggcc aggcggggga cgtcgacgca gtcgtcaccc cggaagcagg cctcgccttg      540

gcggtgctgg tggcggactg cctgcccctg ctggtcgcgg acgccgcagc cggggtgatc      600

ggcgcggcgc acgcgggacg cccgggcatg gcggcgggag tggtgcctgc cctggtggcg      660

gagatggccc ggcacggggc gcgccccgag cggtgtgttg ccctcctggg gcccgcgatc      720

tgcggccgct gctacgaggt gccccgcgac ctgcaggaca gggtggcccg cacggttcca      780

gaagcccgct gcacaaccgc ggaaggcaca ccaggactag acattcgagc cggagtcacc      840

gcacagttga cgaacttggg cgtgacgaat atcactcatg acagtcggtg tactcgggag      900

agcgccgact tgttctccta ccgcagagac gcgaccaccg gacggttcgc cggatatgtc      960

tggagggtcc catga                                                       975


<210>  17
<211>  2118
<212>  DNA
<213>  Artificial sequence

<220>
<223>  recombinant enzyme

<400>  17
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac tactagtggt tctggttccg cgggtgaaaa cctgtacttc     1140

cagggtggca gcagccatca ccatcatcac cacactagtc ctgtaattgt atatggagat     1200

tataacaatg atggaaatgt tgatgcactt gattttgcag gcttaaagaa atatattatg     1260

gctgctgacc atgcttatgt aaagaatttg gatgttaatc tcgacaatga agtgaatgca     1320

tttgaccttg ctattttgaa aaaatatctg cttggtatgg taagtaagct acctagccag     1380

gatccgaatt cagtgacggg caccgtggtc gagttggccc ccgggataca cgccggattc     1440

accggccgtg ccggaggagt cagcggggag ccgtacgcga ccctgaacct gggcgaccac     1500

gtgggtgacg accctgcagc ggtggcggag aaccggagac gggccgccct cgggttcggg     1560

atctcccccg accgcgtggt gtggatgaac caggtgcacg gcgccaccgc ggtgaccgtg     1620

accggatccg gccaggcggg ggacgtcgac gcagtcgtca ccccggaagc aggcctcgcc     1680

ttggcggtgc tggtggcgga ctgcctgccc ctgctggtcg cggacgccgc agccggggtg     1740

atcggcgcgg cgcacgcggg acgcccgggc atggcggcgg gagtggtgcc tgccctggtg     1800

gcggagatgg cccggcacgg ggcgcgcccc gagcggtgtg ttgccctcct ggggcccgcg     1860

atctgcggcc gctgctacga ggtgccccgc gacctgcagg acagggtggc ccgcacggtt     1920

ccagaagccc gctgcacaac cgcggaaggc acaccaggac tagacattcg agccggagtc     1980

accgcacagt tgacgaactt gggcgtgacg aatatcactc atgacagtcg gtgtactcgg     2040

gagagcgccg acttgttctc ctaccgcaga gacgcgacca ccggacggtt cgccggatat     2100

gtctggaggg tcccatga                                                   2118


<210>  18
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
attatgcata tgcaccatca ccatcaccac gatgtagtaa ttacgtcaaa ccagac           56


<210>  19
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
attctactcg agattatcac tagtaggtgt aggtgtagga tttaca                      46


<210>  20
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
ctacaactag tactacaaca ccaacgccta aat                                    33


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
tataccatgg tgacgggcac cgt                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
ggtgctcgag tgggaccctc cag                                               23


<210>  23
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
cggttcgccg gatatgtctg gagggtccca actagtcctg taattgtat                   49


<210>  24
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
ggtggcagca gcctaggtta attaagctgc ttaaggtagc ttacttacc                   49


<210>  25
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
atgggcagca gccatcacca tcatcaccac aagaatgcag attcctatgc gaaaaaacct       60


<210>  26
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
accctggaag tacaggtttt cacccgcgga tttgtggtcg ataatagccc aatatgcggg       60


<210>  27
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
tataccatgg cacatcacca tcaccatcac gcagttgaaa gcagttccac                  50


<210>  28
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
gtcacctcgg ccgagtcgtg gccgggtacc tctgtaataa tgcggagtat                  50


