                         SEQUENCE LISTING

<110>  Alex Levitzki Management and Holdings, Ltd
 
<120>  CHIMERIC PROTEINS FOR TARGETING dsRNA

<130>  3152/1.2

<150>  62/383,466
<151>  2016-09-04

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ser Gly Gly Gly Gly Ser Arg Arg Arg Arg Arg Arg 
            260                 265                 270         


Arg Arg Gly Arg Lys Ala Ser Ala Glu Val Gln Leu Gln Gln Ser Gly 
        275                 280                 285             


Pro Glu Leu Val Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr 
    290                 295                 300                 


Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser 
305                 310                 315                 320 


His Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly 
                325                 330                 335     


Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val 
            340                 345                 350         


Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser 
        355                 360                 365             


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
                405                 410                 415     


Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile 
            420                 425                 430         


Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
    450                 455                 460                 


His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
465                 470                 475                 480 


Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr 
                485                 490                 495     


Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
            500                 505                 510         


Met Leu Asp Leu Lys 
        515         


<210>  2
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant polynucleotide

<400>  2
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      120

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      180

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      240

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      300

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      360

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      420

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      480

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      540

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      600

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      660

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      720

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaaa      780

agcggcggtg gcggatcccg tcgtcgccgt cgtcgccgtc gcggccgcaa agcttccgca      840

gaggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc agtgaggata      900

tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt gaagcagagc      960

catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg taccacctac     1020

aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag tacagcctac     1080

atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc agctggttgg     1140

aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg aggtggatca     1200

ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc tcacaaattc     1260

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt     1320

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg     1380

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac     1440

ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt ctgtcagcaa     1500

tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa ataa           1554


<210>  3
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met 
            20                  25                  30          


Glu Glu Leu Asn Thr Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr 
        35                  40                  45              


Gln Glu Leu Pro Asn Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe 
    50                  55                  60                  


Gln Val Ile Ile Asp Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser 
65                  70                  75                  80  


Lys Lys Glu Ala Lys Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu 
                85                  90                  95      


Asn Lys Glu Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn 
            100                 105                 110         


Ser Ser Glu Gly Leu Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg 
        115                 120                 125             


Ile Ala Gln Lys Lys Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser 
    130                 135                 140                 


Gly Val His Gly Pro Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln 
145                 150                 155                 160 


Lys Glu Tyr Ser Ile Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln 
                165                 170                 175     


Leu Ala Ala Lys Leu Ala Tyr Leu Gln Ile Leu Ser Glu Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Arg Arg Arg Arg Arg Arg Arg Arg Gly Arg Lys Ala Ser 
        195                 200                 205             


Ala Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    210                 215                 220                 


Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu 
225                 230                 235                 240 


Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
                245                 250                 255     


Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys 
            260                 265                 270         


Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
        275                 280                 285             


Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
    290                 295                 300                 


Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
305                 310                 315                 320 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
            340                 345                 350         


Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val 
        355                 360                 365             


Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    370                 375                 380                 


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
385                 390                 395                 400 


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn 
                405                 410                 415     


Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser 
            420                 425                 430         


Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys 
        435                 440                 445     


<210>  4
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant polynucleotide

<400>  4
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgatggctg gtgatctttc agcaggtttc ttcatggagg aacttaatac ataccgtcag      120

aagcagggag tagtacttaa atatcaagaa ctgcctaatt caggacctcc acatgatagg      180

aggtttacat ttcaagttat aatagatgga agagaatttc cagaaggtga aggtagatca      240

aagaaggaag caaaaaatgc cgcagccaaa ttagctgttg agatacttaa taaggaaaag      300

aaggcagtta gtcctttatt attgacaaca acgaattctt cagaaggatt atccatgggg      360

aattacatag gccttatcaa tagaattgcc cagaagaaaa gactaactgt aaattatgaa      420

cagtgtgcat cgggggtgca tgggccagaa ggatttcatt ataaatgcaa aatgggacag      480

aaagaatata gtattggtac aggttctact aaacaggaag caaaacaatt ggcggccaaa      540

ctggcctatc tgcagatctt atcggagagc ggcggtggcg gatcccgtcg tcgccgtcgt      600

cgccgtcgcg gccgcaaagc ttccgcagag gtgcagctgc agcagtcagg acctgaactg      660

gtgaagcctg ggacttcagt gaggatatcc tgcaagactt ctggatacac attcactgaa      720

tataccatac actgggtgaa gcagagccat ggaaagagcc ttgagtggat tggaaacatc      780

aatcctaaca atggtggtac cacctacaat cagaagttcg aggacaaggc cacattgact      840

gtagacaagt cctccagtac agcctacatg gagctccgca gcctaacatc tgaggattct      900

gcagtctatt attgtgcagc tggttggaac tttgactact ggggccaagg gaccacggtc      960

accgtctcct caggtggagg tggatcaggt ggaggtggat ctggtggagg tggatctgac     1020

attgtgatga cccagtctca caaattcatg tccacatcag taggagacag ggtcagcatc     1080

atctgtaagg ccagtcaaga tgtgggtact gctgtagact ggtatcaaca gaaaccagga     1140

caatctccta aactactgat ttattgggca tccactcggc acactggagt ccctgatcgc     1200

ttcacaggca gtggatctgg gacagacttc actctcacca ttactaatgt tcagtctgaa     1260

gacttggcag attatttctg tcagcaatat aacagctatc ccctcacgtt cggtgctggg     1320

accatgctgg acctgaaa                                                   1338


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oligopeptide

<400>  5

Gly Ser Arg Arg Arg Arg Arg Arg Arg Arg Gly Arg Lys Ala 
1               5                   10                  


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
atgaccaaca agtgtctcct cc                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gctcatggaa agagctgtag tg                                                22


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gagccacatc gctcagac                                                     18


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
cttctcatgg ttcacaccc                                                    19


<210>  10
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
tttactcgag cggaggtgca gctgcagc                                          28


<210>  11
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
ttttgctcag cgccgttaca ggtccagcca tg                                     32


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
ttttcatatg gtgagcaagg gcg                                               23


<210>  13
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
taaggatccg ccaccgccgc ttttcttgta cagc                                   34


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
tttcatatga tggctggtga tc                                                22


<210>  15
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
ttaggatccg ccaccgccgc tctccgataa gatctgcag                              39


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
gatcccgtcg tcgccgtcgt cgccgtcgcg gccgcaa                                37


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
agctttgcgg ccgcgacggc gacgacggcg acgacgg                                37


<210>  18
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn 
1               5                   10                  15      


Thr Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro 
            20                  25                  30          


Asn Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile 
        35                  40                  45              


Asp Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala 
    50                  55                  60                  


Lys Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys 
65                  70                  75                  80  


Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly 
                85                  90                  95      


Leu Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys 
            100                 105                 110         


Lys Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly 
        115                 120                 125             


Pro Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser 
    130                 135                 140                 


Ile Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys 
145                 150                 155                 160 


Leu Ala Tyr Leu Gln Ile Leu Ser Glu 
                165                 


<210>  19
<211>  507
<212>  DNA
<213>  Homo sapiens

<400>  19
atgatggctg gtgatctttc agcaggtttc ttcatggagg aacttaatac ataccgtcag       60

aagcagggag tagtacttaa atatcaagaa ctgcctaatt caggacctcc acatgatagg      120

aggtttacat ttcaagttat aatagatgga agagaatttc cagaaggtga aggtagatca      180

aagaaggaag caaaaaatgc cgcagccaaa ttagctgttg agatacttaa taaggaaaag      240

aaggcagtta gtcctttatt attgacaaca acgaattctt cagaaggatt atccatgggg      300

aattacatag gccttatcaa tagaattgcc cagaagaaaa gactaactgt aaattatgaa      360

cagtgtgcat cgggggtgca tgggccagaa ggatttcatt ataaatgcaa aatgggacag      420

aaagaatata gtattggtac aggttctact aaacaggaag caaaacaatt ggcggccaaa      480

ctggcctatc tgcagatctt atcggag                                          507


<210>  20
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly 
145                 150                 155                 160 


Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe 
            180                 185                 190         


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val 
        195                 200                 205             


Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr 
    210                 215                 220                 


Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys 
225                 230                 235         


<210>  21
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
gaggtgcagc tgcagcagtc aggacctgaa ctggtgaagc ctgggacttc agtgaggata       60

tcctgcaaga cttctggata cacattcact gaatatacca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggaaac atcaatccta acaatggtgg taccacctac      180

aatcagaagt tcgaggacaa ggccacattg actgtagaca agtcctccag tacagcctac      240

atggagctcc gcagcctaac atctgaggat tctgcagtct attattgtgc agctggttgg      300

aactttgact actggggcca agggaccacg gtcaccgtct cctcaggtgg aggtggatca      360

ggtggaggtg gatctggtgg aggtggatct gacattgtga tgacccagtc tcacaaattc      420

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt      480

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg      540

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac      600

ttcactctca ccattactaa tgttcagtct gaagacttgg cagattattt ctgtcagcaa      660

tataacagct atcccctcac gttcggtgct gggaccatgc tggacctgaa a               711


