                         SEQUENCE LISTING

<110>  PsiOxus Therapeutics Limited
 
<120>  Adenovirus armed with bispecific T cell engager (BiTE)

<130>  P000192_WO2

<150>  GB1614607.8
<151>  2016-08-29

<160>  297   

<170>  PatentIn version 3.5

<210>  1
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM BiTE DNA coding sequence, with N-terminal signal 
       sequence and C-terminal deca-His affinity tag

<400>  1
atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt gcatagcgaa       60

ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa ggtcaccatg      120

tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta cctcacgtgg      180

tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag cacccgcgag      240

tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac cctaaccatc      300

agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta ctcgtaccct      360

ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag cggcggggga      420

ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc cgaactggtc      480

cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt taccaattac      540

tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg cgacatcttc      600

ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac tctgactgcc      660

gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga agacagcgcg      720

gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg gggacaagga      780

actaccgtga ccgtctcctc cggcggcggt ggaagcgatg tgcaactcgt gcagtccggt      840

gcggaagtga aaaagccggg cgcgagcgtc aaagtgtcat gcaaggcgtc aggatatacg      900

tttactagat acactatgca ctgggtgcgc caggcacctg gtcagggcct tgaatggatc      960

ggctacatca atccgtcgag aggctacact aattacgcgg actcagtcaa agggcgcttc     1020

acgattacga ccgacaagtc cacctcgact gcatacatgg aactgtcctc gctgagaagc     1080

gaggacaccg ctacttacta ctgcgctaga tactacgatg atcactactg cctcgattac     1140

tggggccagg gaaccactgt cacggtgtca tcgggagagg gcacctcaac cggatcaggg     1200

ggatcgggag gctcgggcgg cgcagacgac atcgtcctga cccagtcgcc cgccaccttg     1260

tcgctgtccc caggagaaag agcgaccctg tcatgccggg cgtcgcaaag cgtgagctat     1320

atgaattggt atcagcagaa gccaggaaag gcgccgaaga gatggatcta cgacacctcc     1380

aaggtcgctt caggtgtccc ggctagattc tcaggatcgg gatcaggaac ggactactcc     1440

ctgaccatca attcactgga agcagaagat gcggccacct actactgtca gcagtggtcc     1500

tccaacccgc tgactttcgg aggcggaact aaggtcgaga tcaagcatca ccatcaccat     1560

caccaccatc accattag                                                   1578


<210>  2
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM BiTE protein sequence, with N-terminal signal sequence
       and C-terminal deca-His affinity tag

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
145                 150                 155                 160 


Arg Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
                165                 170                 175     


Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
    290                 295                 300                 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            420                 425                 430         


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
465                 470                 475                 480 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys His His His His His His His His His His 
        515                 520                 525 


<210>  3
<211>  1590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-FAP BiTE DNA coding sequence, with N-terminal signal 
       sequence and C-terminal deca-His affinity tag

<400>  3
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaga tgtgcaactc      840

gtgcagtccg gtgcggaagt gaaaaagccg ggcgcgagcg tcaaagtgtc atgcaaggcg      900

tcaggatata cgtttactag atacactatg cactgggtgc gccaggcacc tggtcagggc      960

cttgaatgga tcggctacat caatccgtcg agaggctaca ctaattacgc ggactcagtc     1020

aaagggcgct tcacgattac gaccgacaag tccacctcga ctgcatacat ggaactgtcc     1080

tcgctgagaa gcgaggacac cgctacttac tactgcgcta gatactacga tgatcactac     1140

tgcctcgatt actggggcca gggaaccact gtcacggtgt catcgggaga gggcacctca     1200

accggatcag ggggatcggg aggctcgggc ggcgcagacg acatcgtcct gacccagtcg     1260

cccgccacct tgtcgctgtc cccaggagaa agagcgaccc tgtcatgccg ggcgtcgcaa     1320

agcgtgagct atatgaattg gtatcagcag aagccaggaa aggcgccgaa gagatggatc     1380

tacgacacct ccaaggtcgc ttcaggtgtc ccggctagat tctcaggatc gggatcagga     1440

acggactact ccctgaccat caattcactg gaagcagaag atgcggccac ctactactgt     1500

cagcagtggt cctccaaccc gctgactttc ggaggcggaa ctaaggtcga gatcaagcat     1560

caccatcacc atcaccacca tcaccattag                                      1590


<210>  4
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP BiTE amino acid sequence, with N-terminal signal 
       sequence and C-terminal deca-His affinity tag

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe 
                165                 170                 175     


Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        275                 280                 285             


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    290                 295                 300                 


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
305                 310                 315                 320 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr 
            340                 345                 350         


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser 
385                 390                 395                 400 


Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
                405                 410                 415     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            420                 425                 430         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    450                 455                 460                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys His His His His His His His His His 
        515                 520                 525             


His 
    


<210>  5
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) BiTE DNA coding sequence, with N-terminal 
       signal sequence and C-terminal deca-His affinity tag

<400>  5
atgggttggt catgcatcat cctgtttctc gtcgcaactg cgaccggcgt gcattcggaa       60

ctggacatcg tgatgaccca ggcacctgca tcactggcag tgagcctggg acagagagcc      120

accatttcat gccgggccag caagagcgtg tcgtcatccg gatacaatta tctgcactgg      180

tatcagcaga aaccaggaca acctccaaag ctactcatct acctggcgtc gaacctcgaa      240

tcgggcgtcc cagctagatt ctcagggagc ggttcgggaa ccgatttcac cctgaacatc      300

caccctgtgg aggaggaaga cgcggcaacg tactattgcc agcattcccg cgagttccct      360

ctcactttcg gtgcgggaac taagctggag atcaagtcca gcggcggcgg aggtagcggt      420

ggaggtggcg gaggaagctc ccggtcgtcg ctggaggtgc agctgcaaca atccggcccg      480

gaactggtca agccaggcgc atccgtcaag atttcatgca agacctcggg gtacaccttc      540

accgggtaca cgatgcattg ggtcaggcag agccacggca agtccctgga atggatcgga      600

ggaatcaacc ccaaaaacgg cggcatcatc tacaaccaaa agttccaggg aaaagccact      660

ctgaccgtgg acaagtcgtc gagcacggcc agcatggagc tgcggtccct cacttccgac      720

gactcagccg tgtattactg cgcgagacgg gtctacgatg actacccata ctactacgct      780

atggactact ggggacaagg aaccagcgtg accgtctcat cggcgaaaac tactccgccg      840

tcggtgacgt cgggaggtgg tggaagcgac gtgcagctcg tccagtcggg tgccgaggtg      900

aagaagccag gagcctccgt gaaggtctcg tgcaaagcca gcggctacac ttttactagg      960

tacactatgc actgggtgcg gcaagcgccg ggacaaggtc tggagtggat cggatacatc     1020

aatccgtcgc ggggatacac taattacgcg gactccgtca agggacggtt tactatcact     1080

acggataagt ccactagcac cgcctacatg gaactgtcct cgctgcggtc ggaagacact     1140

gcgacctact actgcgctag atattacgat gaccactact gcctcgacta ttgggggcag     1200

ggcactacgg tcaccgtctc gtcgggagaa ggaacctcaa ctggatcggg cggatcggga     1260

ggctccggag gagccgacga catcgtgctt acccagtcgc ctgcgaccct gtccctgtcc     1320

ccaggagaga gagcgactct ttcatgcagg gcttcccaat cagtctccta catgaattgg     1380

tatcaacaaa aacccggcaa ggccccgaaa cgctggatct acgatacttc aaaggtggcc     1440

agcggtgtgc ctgcccgctt ctccgggtcg gggtccggca ccgattactc gttgactatc     1500

aatagcctgg aggccgagga cgctgcaact tactactgcc agcagtggtc ctccaaccct     1560

ctcaccttcg gaggcgggac caaggtggaa atcaaacatc accatcacca tcaccaccat     1620

caccattag                                                             1629


<210>  6
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) BiTE amino acid sequence with N-terminal 
       signal sequence and C-terminal deca-His affinity tag

<400>  6

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Ser Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His 
            180                 185                 190         


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly 
        195                 200                 205             


Ile Ile Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro 
                245                 250                 255     


Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            260                 265                 270         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Thr Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
305                 310                 315                 320 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
        355                 360                 365             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
    450                 455                 460                 


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
465                 470                 475                 480 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                485                 490                 495     


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Val Glu Ile Lys His His His His His His His His His His 
    530                 535                 540         


<210>  7
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 ScFv amino acid sequence

<400>  7

Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  8
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 VH

<400>  8

Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 VL

<400>  9

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 ScFv linker sequence

<400>  10

Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ala Asp 
        


<210>  11
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP ScFv

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr 
145                 150                 155                 160 


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
                165                 170                 175     


Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP VL domain

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP VH domain

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP and Anti-EpCAM linker sequence

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BiTe leader sequence

<400>  15

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  16
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM ScFv

<400>  16

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser 
                245             


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM VL

<400>  17

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM VH

<400>  18

Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control BiTe (Anti-FHA)

<400>  19

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Ser Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His 
            180                 185                 190         


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly 
        195                 200                 205             


Ile Ile Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro 
                245                 250                 255     


Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            260                 265                 270         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Thr Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
305                 310                 315                 320 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
        355                 360                 365             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
    450                 455                 460                 


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
465                 470                 475                 480 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                485                 490                 495     


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Val Glu Ile Lys His His His His His His His His His His 
    530                 535                 540         


<210>  20
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) ScFv

<400>  20

Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser 
            20                  25                  30          


Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His 
                85                  90                  95      


Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His Gly Lys Ser 
                165                 170                 175     


Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly Ile Ile Tyr 
            180                 185                 190         


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
        195                 200                 205             


Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro Tyr Tyr Tyr 
225                 230                 235                 240 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
                245                 250                 255     


Lys Thr Thr Pro Pro Ser Val Thr Ser 
            260                 265 


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) VL

<400>  21

Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser 
            20                  25                  30          


Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His 
                85                  90                  95      


Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  22
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) VH

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Lys Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Val Tyr Asp Asp Tyr Pro Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120                 125             


Pro Ser Val Thr Ser 
    130             


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) ScFv linker sequence

<400>  23

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg 
1               5                   10                  15      


Ser Ser Leu 
            


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Deca-His Tag sequence

<400>  24

His His His His His His His His His His 
1               5                   10  


<210>  25
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP BiTE-P2A-RFP

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe 
                165                 170                 175     


Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        275                 280                 285             


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    290                 295                 300                 


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
305                 310                 315                 320 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr 
            340                 345                 350         


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser 
385                 390                 395                 400 


Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
                405                 410                 415     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            420                 425                 430         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    450                 455                 460                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys His His His His His His His His His 
        515                 520                 525             


His Arg Arg Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    530                 535                 540                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Glu Leu Ile 
545                 550                 555                 560 


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asn Asn 
                565                 570                 575     


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
            580                 585                 590         


Thr Gln Thr Met Lys Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
        595                 600                 605             


Ala Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr Gly Ser Lys Ala Phe 
    610                 615                 620                 


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
625                 630                 635                 640 


Glu Gly Phe Thr Trp Glu Arg Ile Thr Thr Tyr Glu Asp Gly Gly Val 
                645                 650                 655     


Leu Thr Ala Thr Gln Asp Thr Ser Phe Gln Asn Gly Cys Ile Ile Tyr 
            660                 665                 670         


Asn Val Lys Ile Asn Gly Val Asn Phe Pro Ser Asn Gly Pro Val Met 
        675                 680                 685             


Gln Lys Lys Thr Arg Gly Trp Glu Ala Asn Thr Glu Met Leu Tyr Pro 
    690                 695                 700                 


Ala Asp Gly Gly Leu Arg Gly His Ser Gln Met Ala Leu Lys Leu Val 
705                 710                 715                 720 


Gly Gly Gly Tyr Leu His Cys Ser Phe Lys Thr Thr Tyr Arg Ser Lys 
                725                 730                 735     


Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Phe His Phe Val Asp His 
            740                 745                 750         


Arg Leu Glu Arg Ile Lys Glu Ala Asp Lys Glu Thr Tyr Val Glu Gln 
        755                 760                 765             


His Glu Met Ala Val Ala Lys Tyr Cys Asp Leu Pro Ser Lys Leu Gly 
    770                 775                 780                 


His Arg 
785     


<210>  26
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) BiTE-P2A-RFP

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Ser Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His 
            180                 185                 190         


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly 
        195                 200                 205             


Ile Ile Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro 
                245                 250                 255     


Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            260                 265                 270         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Thr Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
305                 310                 315                 320 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
        355                 360                 365             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
    450                 455                 460                 


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
465                 470                 475                 480 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                485                 490                 495     


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Val Glu Ile Lys His His His His His His His His His His Arg Arg 
    530                 535                 540                 


Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
545                 550                 555                 560 


Asp Val Glu Glu Asn Pro Gly Pro Met Ser Glu Leu Ile Lys Glu Asn 
                565                 570                 575     


Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asn Asn His His Phe 
            580                 585                 590         


Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr 
        595                 600                 605             


Met Lys Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp 
    610                 615                 620                 


Ile Leu Ala Thr Ser Phe Met Tyr Gly Ser Lys Ala Phe Ile Asn His 
625                 630                 635                 640 


Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe 
                645                 650                 655     


Thr Trp Glu Arg Ile Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala 
            660                 665                 670         


Thr Gln Asp Thr Ser Phe Gln Asn Gly Cys Ile Ile Tyr Asn Val Lys 
        675                 680                 685             


Ile Asn Gly Val Asn Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys 
    690                 695                 700                 


Thr Arg Gly Trp Glu Ala Asn Thr Glu Met Leu Tyr Pro Ala Asp Gly 
705                 710                 715                 720 


Gly Leu Arg Gly His Ser Gln Met Ala Leu Lys Leu Val Gly Gly Gly 
                725                 730                 735     


Tyr Leu His Cys Ser Phe Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala 
            740                 745                 750         


Lys Asn Leu Lys Met Pro Gly Phe His Phe Val Asp His Arg Leu Glu 
        755                 760                 765             


Arg Ile Lys Glu Ala Asp Lys Glu Thr Tyr Val Glu Gln His Glu Met 
    770                 775                 780                 


Ala Val Ala Lys Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Arg 
785                 790                 795                 


<210>  27
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EpCAM DNA coding sequence

<400>  27
atggctccgc cgcaagtgct cgcctttgga ctgctcctgg ccgctgctac tgccaccttt       60

gctgccgctc aggaagaatg cgtgtgcgaa aactacaaac tggcagtgaa ctgcttcgtg      120

aacaataacc gccaatgcca gtgcaccagc gtgggcgcgc agaacactgt catctgcagc      180

aagctggccg caaaatgcct ggtcatgaaa gcggagatga acggatcgaa gctgggtcgg      240

cgcgctaagc cggaaggagc gctacaaaat aacgacgggc tgtacgatcc ggattgcgac      300

gaaagcggtc tgtttaaggc aaagcagtgt aatgggacca gcatgtgttg gtgcgtgaac      360

actgccggag tgcgccgcac tgacaaggat accgaaatta cgtgctcgga gcgcgtgaga      420

acgtattgga tcatcatcga gttgaagcat aaagctagag agaagccgta cgatagcaag      480

tccctgcgca ccgctctcca aaaagaaatt accactagat accaactcga cccgaaattc      540

atcacttcaa tcctgtacga aaacaacgtg attacgatcg acctggtgca gaactccagc      600

caaaagacgc agaacgacgt ggacattgca gacgtggctt actactttga aaaggacgtg      660

aagggggaat cactatttca ttccaagaaa atggacctga ccgtcaacgg agagcagctc      720

gacctggacc caggtcagac tctgatctac tacgtggacg agaaggcacc ggagttttcg      780

atgcagggcc tgaaagccgg agtcatcgcc gtgatcgtgg tggtggtgat tgccgtcgtc      840

gccgggatcg tggtgctcgt gattagccgc aaaaagagaa tggctaagta tgaaaaggca      900

gagatcaagg aaatgggaga aatgcaccgc gaactcaacg catag                      945


<210>  28
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human EpCAM amino acid sequence

<400>  28

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  29
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human FAP DNA coding sequence

<400>  29
atgaagacct gggtgaaaat cgtgtttgga gtcgcaacca gcgccgtgct ggccctgttg       60

gtgatgtgca tcgtgctgcg cccgtcacgc gtgcataaca gcgaagaaaa caccatgaga      120

gctctgacgc taaaggacat cctgaatggc actttttcct ataagacttt cttcccgaat      180

tggattagcg ggcaggagta cctgcaccaa tcggcggata acaatatcgt gctctacaac      240

atcgaaactg gccagagcta caccatcctg tcgaatagaa ctatgaaatc ggtgaatgcg      300

tcgaactacg gacttagccc ggaccgccag ttcgtgtacc tagaatcgga ctacagcaag      360

ctgtggcggt acagctacac tgctacgtac tacatctacg acctgtcgaa tggcgagttc      420

gtgagaggaa acgaactccc ccgcccgatc caatacctgt gctggagccc tgtgggaagc      480

aagctggcgt acgtgtatca gaacaacatc tacctcaagc agaggccggg cgacccacct      540

ttccagatca cttttaacgg tcgggagaac aagattttca atggaatccc ggattgggtg      600

tacgaagaag agatgctggc gaccaaatat gcgctctggt ggtcgccaaa cggaaaattt      660

ctagcatacg ccgagttcaa tgacaccgac atccccgtca tcgcctacag ctactacgga      720

gatgagcaat acccacgcac tattaatatc ccgtacccga aagccggcgc taaaaatccg      780

gtcgtgcgga tcttcatcat cgacactacc tatccagctt acgtgggacc gcaagaggtc      840

cctgtgccag ccatgatcgc cagcagcgat tactacttct cctggctgac ttgggtcact      900

gacgagaggg tgtgcctcca atggctcaag cgcgtgcaga acgtgagcgt gctgtccatc      960

tgcgacttca gagaagattg gcaaacgtgg gactgtccga aaactcaaga gcatatcgag     1020

gagagcagaa ccggatgggc aggggggttc ttcgtgtcca ccccggtgtt cagctacgat     1080

gcgatctcgt actacaagat tttctccgat aaggacgggt acaaacatat ccactacatc     1140

aaggacaccg tggagaatgc gatccaaatc actagcggaa aatgggaagc gattaacatt     1200

ttccgggtga cgcaagactc attgttctat tcatccaatg aatttgaaga gtaccctggc     1260

cggaggaaca tctaccgcat ctccatcgga tcatacccac catcaaagaa gtgcgtgacc     1320

tgccatctcc gcaaggagcg ctgccaatac tacaccgcgt ccttctccga ttacgcgaag     1380

tactacgccc tggtgtgcta cggcccggga atcccaatct cgaccctaca tgatgggcgc     1440

accgaccagg agatcaaaat cctggaggaa aacaaggagc tcgaaaatgc tctgaaaaat     1500

attcaactac cgaaggagga aatcaagaag ctggaggtgg atgaaattac tctgtggtac     1560

aaaatgatcc tgccgccaca gttcgaccgc tccaagaagt acccgctgct gatccaggtg     1620

tacggaggac cctgctcaca gtcggtgcgc tcagtgtttg ctgtgaattg gatcagctac     1680

ctcgcatcaa aggaggggat ggtcatcgcg cttgtggacg gaagaggtac tgcattccag     1740

ggggacaaac tgctctacgc ggtgtaccgc aagctgggcg tctacgaggt ggaggaccaa     1800

atcacggcgg tcagaaagtt catcgagatg ggtttcatcg acgagaagag gatcgccatc     1860

tggggctggt cgtacggagg ttacgtgtcg tcactcgctc tggcgagcgg gactggattg     1920

ttcaaatgcg gtatcgcagt cgcccccgtg tcgtcatggg aatactacgc ctcggtgtat     1980

accgaacgct ttatgggact ccctactaaa gacgataacc tagagcacta caaaaactcg     2040

acggtgatgg cacgcgcaga gtactttcgc aatgtggatt acctcctgat ccacggaacc     2100

gccgatgata atgtccactt ccagaactca gcccaaatcg cgaaagccct ggtgaacgct     2160

caagtggact ttcaagcaat gtggtattca gaccagaacc acggactatc cggcctatcg     2220

actaatcacc tgtacaccca tatgacccat ttccttaaac agtgtttcag cctgtccgat     2280

tag                                                                   2283


<210>  30
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FAP amino acid sequence

<400>  30

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  31
<211>  571
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter sequence

<400>  31
agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac       60

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      120

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      180

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      240

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      300

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atgctgatgc      360

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      420

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      480

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      540

tctatataag cagagctggt ttagtgaacc g                                     571


<210>  32
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 late polyadenylation sequence

<400>  32
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38
<211>  32326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EnAd genome

<400>  38
tctatctata taatatacct tatagatgga atggtgccaa tatgtaaatg aggtgatttt       60

aaaaagtgtg gatcgtgtgg tgattggctg tggggttaac ggctaaaagg ggcggtgcga      120

ccgtgggaaa atgacgtttt gtgggggtgg agtttttttg caagttgtcg cgggaaatgt      180

gacgcataaa aaggcttttt tctcacggaa ctacttagtt ttcccacggt atttaacagg      240

aaatgaggta gttttgaccg gatgcaagtg aaaattgttg attttcgcgc gaaaactgaa      300

tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg      360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt      420

ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctagggtatt      480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc      540

tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat      600

aatctctgct gagactggaa atgaaatatt ggagcttgtg gtgcacgccc tgatgggaga      660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt      720

agaggtagag ggatcggagg attctaatga ggaagctgta aatggctttt ttaccgattc      780

tatgctttta gctgctaatg aagggttaga attagatccg cctttggaca cttttgatac      840

tccaggggta attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgagttccgt      900

ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga      960

aaaggagcag tccatgcaga ctgcagcggg tgagggagtg aaggctgcca atgttggttt     1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa     1080

aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagaacgc actgccactt     1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat     1200

attgagtgtg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgaatcacc     1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg     1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga     1380

cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacgtc caagacaata     1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaca gtgcaatgta     1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata     1560

taagtagaag cagacctgtg tggttagctc ataggagctg gctttcatcc atggaggttt     1620

gggccatttt ggaagacctt aggaagacta ggcaactgtt agagaacgct tcggacggag     1680

tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa     1740

aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag     1800

ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt ttagactttt     1860

caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta gataaatgga     1920

tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca gcattgtgga     1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg     2040

gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc     2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt     2160

gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt     2220

taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat     2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtt cagaaagagg gaagggatga     2340

agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc     2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa     2460

acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg     2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat     2580

gtggcctggg gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga     2640

tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt     2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag     2760

tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa     2820

atgcatattt caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca     2880

ctgcgcttct acagatactg gatgttttat tttgattaag ggaaatgcca gcgtaaagca     2940

taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgctggtgg     3000

gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt     3060

ttttgatcac aatgtgatga cgaagtgtac catgcatgca ggtgggcgta gaggaatgtt     3120

tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc     3180

cagaatgagc ctaacaggaa tttttgacat gaacatgcaa atctggaaga tcctgaggta     3240

tgatgatacg agatcgaggg tacgcgcatg cgaatgcgga ggcaagcatg ccaggttcca     3300

gccggtgtgt gtagatgtga ctgaagatct cagaccggat catttggtta ttgcccgcac     3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt     3420

tggggtggga ttttcagatg gacagattga gtaaaaattt gttttttctg tcttgcagct     3480

gtcatgagtg gaaacgcttc ttttaagggg ggagtcttca gcccttatct gacagggcgt     3540

ctcccatcct gggcaggagt tcgtcagaat gttatgggat ctactgtgga tggaagaccc     3600

gtccaacccg ccaattcttc aacgctgacc tatgctactt taagttcttc acctttggac     3660

gcagctgcag ctgccgccgc cgcttctgtt gccgctaaca ctgtgcttgg aatgggttac     3720

tatggaagca tcatggctaa ttccacttcc tctaataacc cttctaccct gactcaggac     3780

aagttacttg tccttttggc ccagctggag gctttgaccc aacgtctggg tgaactttct     3840

cagcaggtgg tcgagttgcg agtacaaact gagtctgctg tcggcacggc aaagtctaaa     3900

taaaaaaatc ccagaatcaa tgaataaata aacaagcttg ttgttgattt aaaatcaagt     3960

gtttttattt catttttcgc gcacggtatg ccctagacca ccgatctcta tcattgagaa     4020

ctcggtggat tttttccagg atcctataga ggtgggattg aatgtttaga tacatgggca     4080

ttaggccgtc tttggggtgg agatagctcc attgaaggga ttcatgctcc ggggtagtgt     4140

tgtaaatcac ccagtcataa caaggtcgca gtgcatggtg ttgcacaata tcttttagaa     4200

gtaggctgat tgccacagat aagcccttgg tgtaggtgtt tacaaaccgg ttgagctggg     4260

atgggtgcat tcggggtgaa attatgtgca ttttggattg gatttttaag ttggcaatat     4320

tgccgccaag atcccgtctt gggttcatgt tatgaaggac caccaagacg gtgtatccgg     4380

tacatttagg aaatttatcg tgcagcttgg atggaaaagc gtggaaaaat ttggagacac     4440

ccttgtgtcc tccaagattt tccatgcact catccatgat aatagcaatg gggccgtggg     4500

cagcggcgcg ggcaaacacg ttccgtgggt ctgacacatc atagttatgt tcctgagtta     4560

aatcatcata agccatttta atgaatttgg ggcggagagt accagattgg ggtatgaatg     4620

ttccttcggg ccccggagca tagttcccct cacagatttg catttcccaa gctttcagtt     4680

ccgagggtgg aatcatgtcc acctgggggg ctatgaaaaa caccgtttct ggggcggggg     4740

tgattaattg tgatgatagc aaatttctga gcaattgaga tttgccacat ccggtggggc     4800

cataaatgat tccgattacg ggttgcaggt ggtagtttag ggaacggcaa ctgccgtctt     4860

ctcgaagcaa gggggccacc tcgttcatca tttcccttac atgcatattt tcccgcacca     4920

aatccattag gaggcgctct cctcctagtg atagaagttc ttgtagtgag gaaaagtttt     4980

tcagcggttt cagaccgtca gccatgggca ttttggagag agtttgctgc aaaagttcta     5040

gtctgttcca cagttcagtg atgtgttcta tggcatctcg atccagcaga cctcctcgtt     5100

tcgcgggttt ggacggctcc tggaataggg tatgagacga tgggcgtcca gcgctgccag     5160

ggttcggtcc ttccagggtc tcagtgttcg agtcagggtt gtttccgtca cagtgaaggg     5220

gtgtgcgcct gcttgggcgc ttgccagggt gcgcttcaga ctcatcctgc tggtcgaaaa     5280

cttctgtcgc ttggcgccct gtatgtcggc caagtagcag tttaccatga gttcgtagtt     5340

gagcgcctcg gctgcgtggc ctttggcgcg gagcttacct ttggaagttt tcttgcatac     5400

cgggcagtat aggcatttca gcgcatacaa cttgggcgca aggaaaacgg attctgggga     5460

gtatgcatct gcgccgcagg aggcgcaaac agtttcacat tccaccagcc aggttaaatc     5520

cggttcattg gggtcaaaaa caagttttcc gccatatttt ttgatgcgtt tcttaccttt     5580

ggtctccatg agttcgtgtc ctcgttgagt gacaaacagg ctgtccgtgt ccccgtagac     5640

tgattttaca ggcctcttct ccagtggagt gcctcggtct tcttcgtaca ggaactctga     5700

ccactctgat acaaaggcgc gcgtccaggc cagcacaaag gaggctatgt gggaggggta     5760

gcgatcgttg tcaaccaggg ggtccacctt ttccaaagta tgcaaacaca tgtcaccctc     5820

ttcaacatcc aggaatgtga ttggcttgta ggtgtatttc acgtgacctg gggtccccgc     5880

tgggggggta taaaaggggg cggttctttg ctcttcctca ctgtcttccg gatcgctgtc     5940

caggaacgtc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctctgcact     6000

caggttgtca gtttctaaga acgaggagga tttgatattg acagtgccgg ttgagatgcc     6060

tttcatgagg ttttcgtcca tctggtcaga aaacacaatt tttttattgt caagtttggt     6120

ggcaaatgat ccatacaggg cgttggataa aagtttggca atggatcgca tggtttggtt     6180

cttttccttg tccgcgcgct ctttggcggc gatgttgagt tggacatact cgcgtgccag     6240

gcacttccat tcggggaaga tagttgttaa ttcatctggc acgattctca cttgccaccc     6300

tcgattatgc aaggtaatta aatccacact ggtggccacc tcgcctcgaa ggggttcatt     6360

ggtccaacag agcctacctc ctttcctaga acagaaaggg ggaagtgggt ctagcataag     6420

ttcatcggga gggtctgcat ccatggtaaa gattcccgga agtaaatcct tatcaaaata     6480

gctgatggga gtggggtcat ctaaggccat ttgccattct cgagctgcca gtgcgcgctc     6540

atatgggtta aggggactgc cccatggcat gggatgggtg agtgcagagg catacatgcc     6600

acagatgtca tagacgtaga tgggatcctc aaagatgcct atgtaggttg gatagcatcg     6660

cccccctctg atacttgctc gcacatagtc atatagttca tgtgatggcg ctagcagccc     6720

cggacccaag ttggtgcgat tgggtttttc tgttctgtag acgatctggc gaaagatggc     6780

gtgagaattg gaagagatgg tgggtctttg aaaaatgttg aaatgggcat gaggtagacc     6840

tacagagtct ctgacaaagt gggcataaga ttcttgaagc ttggttacca gttcggcggt     6900

gacaagtacg tctagggcgc agtagtcaag tgtttcttga atgatgtcat aacctggttg     6960

gtttttcttt tcccacagtt cgcggttgag aaggtattct tcgcgatcct tccagtactc     7020

ttctagcgga aacccgtctt tgtctgcacg gtaagatcct agcatgtaga actgattaac     7080

tgccttgtaa gggcagcagc ccttctctac gggtagagag tatgcttgag cagcttttcg     7140

tagcgaagcg tgagtaaggg caaaggtgtc tctgaccatg actttgagga attggtattt     7200

gaagtcgatg tcgtcacagg ctccctgttc ccagagttgg aagtctaccc gtttcttgta     7260

ggcggggttg ggcaaagcga aagtaacatc attgaagaga atcttgccgg ccctgggcat     7320

gaaattgcga gtgatgcgaa aaggctgtgg tacttccgct cggttattga taacctgggc     7380

agctaggacg atctcgtcga aaccgttgat gttgtgtcct acgatgtata attctatgaa     7440

acgcggcgtg cctctgacgt gaggtagctt actgagctca tcaaaggtta ggtctgtggg     7500

gtcagataag gcgtagtgtt cgagagccca ttcgtgcagg tgaggattcg ctttaaggaa     7560

ggaggaccag aggtccactg ccagtgctgt ttgtaactgg tcccggtact gacgaaaatg     7620

ccgtccgact gccatttttt ctggggtgac gcaatagaag gtttgggggt cctgccgcca     7680

gcgatcccac ttgagtttta tggcgaggtc ataggcgatg ttgacgagcc gctggtctcc     7740

agagagtttc atgaccagca tgaaggggat tagctgcttg ccaaaggacc ccatccaggt     7800

gtaggtttcc acatcgtagg tgagaaagag cctttctgtg cgaggatgag agccaatcgg     7860

gaagaactgg atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa     7920

ctccctgcga cgcgccgagc attcatgctt gtgcttgtac agacggccgc agtagtcgca     7980

gcgttgcacg ggttgtatct cgtgaatgag ttgtacctgg cttcccttga cgagaaattt     8040

cagtgggaag ccgaggcctg gcgattgtat ctcgtgcttt actatgttgt ctgcatcggc     8100

ctgttcatct tctgtctcga tggtggtcat gctgacgagc cctcgcggga ggcaagtcca     8160

gacctcggcg cggcaggggc ggagctcgag gacgagagcg cgcaggctgg agctgtccag     8220

ggtcctgaga cgctgcggac tcaggttagt aggcagtgtc aggagattaa cttgcatgat     8280

cttttggagg gcgtgcggga ggttcagata gtacttgatc tcaacgggtc cgttggtgga     8340

gatgtcgatg gcttgcaggg ttccgtgtcc cttgggcgct accaccgtgc ccttgttttt     8400

cattttggac ggcggtggct ctgttgcttc ttgcatgttt agaagcggtg tcgagggcgc     8460

gcaccgggcg gcaggggcgg ctcgggaccc ggcggcatgg ctggcagtgg tacgtcggcg     8520

ccgcgcgcgg gtaggttctg gtactgcgcc ctgagaagac tcgcatgcgc gacgacgcgg     8580

cggttgacat cctggatctg acgcctctgg gtgaaagcta ccggccccgt gagcttgaac     8640

ctgaaagaga gttcaacaga atcaatctcg gtatcgttga cggcggcttg cctaaggatt     8700

tcttgcacgt caccagagtt gtcctggtag gcgatctccg ccatgaactg ctcgatctct     8760

tcctcttgaa gatctccgcg gcccgctctc tcgacggtgg ccgcgaggtc gttggagatg     8820

cgcccaatga gttgagagaa tgcattcatg cccgcctcgt tccagacgcg gctgtagacc     8880

acggccccca cgggatctct cgcgcgcatg accacctggg cgaggttgag ctccacgtgg     8940

cgggtgaaga ccgcatagtt gcataggcgc tggaaaaggt agttgagtgt ggtggcgatg     9000

tgctcggtga cgaagaaata catgatccat cgtctcagcg gcatctcgct gacatcgccc     9060

agagcttcca agcgctccat ggcctcgtag aagtccacgg caaaattaaa aaactgggag     9120

tttcgcgcgg acacggtcaa ctcctcttcc agaagacgga taagttcggc gatggtggtg     9180

cgcacctcgc gctcgaaagc ccctgggatt tcttcctcaa tctcttcttc ttccactaac     9240

atctcttcct cttcaggtgg ggctgcagga ggagggggaa cgcggcgacg ccggcggcgc     9300

acgggcagac ggtcgatgaa tctttcaatg acctctccgc ggcggcggcg catggtttca     9360

gtgacggcgc ggccgttctc gcgcggtcgc agagtaaaaa caccgccgcg catctcctta     9420

aagtggtgac tgggaggttc tccgtttggg agggagaggg cgctgattat acattttatt     9480

aattggcccg tagggactgc acgcagagat ctgatcgtgt caagatccac gggatctgaa     9540

aacctttcga cgaaagcgtc taaccagtca cagtcacaag gtaggctgag tacggcttct     9600

tgtgggcggg ggtggttatg tgttcggtct gggtcttctg tttcttcttc atctcgggaa     9660

ggtgagacga tgctgctggt gatgaaatta aagtaggcag ttctaagacg gcggatggtg     9720

gcgaggagca ccaggtcttt gggtccggct tgctggatac gcaggcgatt ggccattccc     9780

caagcattat cctgacatct agcaagatct ttgtagtagt cttgcatgag ccgttctacg     9840

ggcacttctt cctcacccgt tctgccatgc atacgtgtga gtccaaatcc gcgcattggt     9900

tgtaccagtg ccaagtcagc tacgactctt tcggcgagga tggcttgctg tacttgggta     9960

agggtggctt gaaagtcatc aaaatccaca aagcggtggt aagctcctgt attaatggtg    10020

taagcacagt tggccatgac tgaccagtta actgtctggt gaccagggcg cacgagctcg    10080

gtgtatttaa ggcgcgaata ggcgcgggtg tcaaagatgt aatcgttgca ggtgcgcacc    10140

agatactggt accctataag aaaatgcggc ggtggttggc ggtagagagg ccatcgttct    10200

gtagctggag cgccaggggc gaggtcttcc aacataaggc ggtgatagcc gtagatgtac    10260

ctggacatcc aggtgattcc tgcggcggta gtagaagccc gaggaaactc gcgtacgcgg    10320

ttccaaatgt tgcgtagcgg catgaagtag ttcattgtag gcacggtttg accagtgagg    10380

cgcgcgcagt cattgatgct ctatagacac ggagaaaatg aaagcgttca gcgactcgac    10440

tccgtagcct ggaggaacgt gaacgggttg ggtcgcggtg taccccggtt cgagacttgt    10500

actcgagccg gccggagccg cggctaacgt ggtattggca ctcccgtctc gacccagcct    10560

acaaaaatcc aggatacgga atcgagtcgt tttgctggtt tccgaatggc agggaagtga    10620

gtcctatttt ttttttttgc cgctcagatg catcccgtgc tgcgacagat gcgcccccaa    10680

caacagcccc cctcgcagca gcagcagcag caatcacaaa aggctgtccc tgcaactact    10740

gcaactgccg ccgtgagcgg tgcgggacag cccgcctatg atctggactt ggaagagggc    10800

gaaggactgg cacgtctagg tgcgccttca cccgagcggc atccgcgagt tcaactgaaa    10860

aaagattctc gcgaggcgta tgtgccccaa cagaacctat ttagagacag aagcggcgag    10920

gagccggagg agatgcgagc ttcccgcttt aacgcgggtc gtgagctgcg tcacggtttg    10980

gaccgaagac gagtgttgcg ggacgaggat ttcgaagttg atgaaatgac agggatcagt    11040

cctgccaggg cacacgtggc tgcagccaac cttgtatcgg cttacgagca gacagtaaag    11100

gaagagcgta acttccaaaa gtcttttaat aatcatgtgc gaaccctgat tgcccgcgaa    11160

gaagttaccc ttggtttgat gcatttgtgg gatttgatgg aagctatcat tcagaaccct    11220

actagcaaac ctctgaccgc ccagctgttt ctggtggtgc aacacagcag agacaatgag    11280

gctttcagag aggcgctgct gaacatcacc gaacccgagg ggagatggtt gtatgatctt    11340

atcaacattc tacagagtat catagtgcag gagcggagcc tgggcctggc cgagaaggtg    11400

gctgccatca attactcggt tttgagcttg ggaaaatatt acgctcgcaa aatctacaag    11460

actccatacg ttcccataga caaggaggtg aagatagatg ggttctacat gcgcatgacg    11520

ctcaaggtct tgaccctgag cgatgatctt ggggtgtatc gcaatgacag aatgcatcgc    11580

gcggttagcg ccagcaggag gcgcgagtta agcgacaggg aactgatgca cagtttgcaa    11640

agagctctga ctggagctgg aaccgagggt gagaattact tcgacatggg agctgacttg    11700

cagtggcagc ctagtcgcag ggctctgagc gccgcgacgg caggatgtga gcttccttac    11760

atagaagagg cggatgaagg cgaggaggaa gagggcgagt acttggaaga ctgatggcac    11820

aacccgtgtt ttttgctaga tggaacagca agcaccggat cccgcaatgc gggcggcgct    11880

gcagagccag ccgtccggca ttaactcctc ggacgattgg acccaggcca tgcaacgtat    11940

catggcgttg acgactcgca accccgaagc ctttagacag caaccccagg ccaaccgtct    12000

atcggccatc atggaagctg tagtgccttc ccgctctaat cccactcatg agaaggtcct    12060

ggccatcgtg aacgcgttgg tggagaacaa agctattcgt ccagatgagg ccggactggt    12120

atacaacgct ctcttagaac gcgtggctcg ctacaacagt agcaatgtgc aaaccaattt    12180

ggaccgtatg ataacagatg tacgcgaagc cgtgtctcag cgcgaaaggt tccagcgtga    12240

tgccaacctg ggttcgctgg tggcgttaaa tgctttcttg agtactcagc ctgctaatgt    12300

gccgcgtggt caacaggatt atactaactt tttaagtgct ttgagactga tggtatcaga    12360

agtacctcag agcgaagtgt atcagtccgg tcctgattac ttctttcaga ctagcagaca    12420

gggcttgcag acggtaaatc tgagccaagc ttttaaaaac cttaaaggtt tgtggggagt    12480

gcatgccccg gtaggagaaa gagcaaccgt gtctagcttg ttaactccga actcccgcct    12540

attattactg ttggtagctc ctttcaccga cagcggtagc atcgaccgta attcctattt    12600

gggttaccta ctaaacctgt atcgcgaagc catagggcaa agtcaggtgg acgagcagac    12660

ctatcaagaa attacccaag tcagtcgcgc tttgggacag gaagacactg gcagtttgga    12720

agccactctg aacttcttgc ttaccaatcg gtctcaaaag atccctcctc aatatgctct    12780

tactgcggag gaggagagga tccttagata tgtgcagcag agcgtgggat tgtttctgat    12840

gcaagagggg gcaactccga ctgcagcact ggacatgaca gcgcgaaata tggagcccag    12900

catgtatgcc agtaaccgac ctttcattaa caaactgctg gactacttgc acagagctgc    12960

cgctatgaac tctgattatt tcaccaatgc catcttaaac ccgcactggc tgcccccacc    13020

tggtttctac acgggcgaat atgacatgcc cgaccctaat gacggatttc tgtgggacga    13080

cgtggacagc gatgtttttt cacctctttc tgatcatcgc acgtggaaaa aggaaggcgg    13140

cgatagaatg cattcttctg catcgctgtc cggggtcatg ggtgctaccg cggctgagcc    13200

cgagtctgca agtccttttc ctagtctacc cttttctcta cacagtgtac gtagcagcga    13260

agtgggtaga ataagtcgcc cgagtttaat gggcgaagag gagtatctaa acgattcctt    13320

gctcagaccg gcaagagaaa aaaatttccc aaacaatgga atagaaagtt tggtggataa    13380

aatgagtaga tggaagactt atgctcagga tcacagagac gagcctggga tcatggggat    13440

tacaagtaga gcgagccgta gacgccagcg ccatgacaga cagaggggtc ttgtgtggga    13500

cgatgaggat tcggccgatg atagcagcgt gctggacttg ggtgggagag gaaggggcaa    13560

cccgtttgct catttgcgcc ctcgcttggg tggtatgttg taaaaaaaaa taaaaaaaaa    13620

actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta    13680

taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt    13740

acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc    13800

cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttattcgg    13860

aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca    13920

ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca    13980

atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt    14040

ggggcggtca gctaaagacc atcatgcata ctaacatgcc aaacgtgaac gagtatatgt    14100

ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcccgac ggtgctgcag    14160

ttggggatac ttatgatcac aagcaggata ttttgaaata tgagtggttc gagtttactt    14220

tgccagaagg caacttttca gttactatga ctattgattt gatgaacaat gccatcatag    14280

ataattactt gaaagtgggt agacagaatg gagtgcttga aagtgacatt ggtgttaagt    14340

tcgacaccag gaacttcaag ctgggatggg atcccgaaac caagttgatc atgcctggag    14400

tgtatacgta tgaagccttc catcctgaca ttgtcttact gcctggctgc ggagtggatt    14460

ttaccgagag tcgtttgagc aaccttcttg gtatcagaaa aaaacagcca tttcaagagg    14520

gttttaagat tttgtatgaa gatttagaag gtggtaatat tccggccctc ttggatgtag    14580

atgcctatga gaacagtaag aaagaacaaa aagccaaaat agaagctgct acagctgctg    14640

cagaagctaa ggcaaacata gttgccagcg actctacaag ggttgctaac gctggagagg    14700

tcagaggaga caattttgcg ccaacacctg ttccgactgc agaatcatta ttggccgatg    14760

tgtctgaagg aacggacgtg aaactcacta ttcaacctgt agaaaaagat agtaagaata    14820

gaagctataa tgtgttggaa gacaaaatca acacagccta tcgcagttgg tatctttcgt    14880

acaattatgg cgatcccgaa aaaggagtgc gttcctggac attgctcacc acctcagatg    14940

tcacctgcgg agcagagcag gtctactggt cgcttccaga catgatgaag gatcctgtca    15000

ctttccgctc cactagacaa gtcagtaact accctgtggt gggtgcagag cttatgcccg    15060

tcttctcaaa gagcttctac aacgaacaag ctgtgtactc ccagcagctc cgccagtcca    15120

cctcgcttac gcacgtcttc aaccgctttc ctgagaacca gattttaatc cgtccgccgg    15180

cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc    15240

cgttgcgcag cagtatccgg ggagtccaac gtgtgaccgt tactgacgcc agacgccgca    15300

cctgtcccta cgtgtacaag gcactgggca tagtcgcacc gcgcgtcctt tcaagccgca    15360

ctttctaaaa aaaaaaaaaa tgtccattct tatctcgccc agtaataaca ccggttgggg    15420

tctgcgcgct ccaagcaaga tgtacggagg cgcacgcaaa cgttctaccc aacatcctgt    15480

ccgtgttcgc ggacattttc gcgctccatg gggcgccctc aagggccgca ctcgcgttcg    15540

aaccaccgtc gatgatgtaa tcgatcaggt ggttgccgac gcccgtaatt atactcctac    15600

tgcgcctaca tctactgtgg atgcagttat tgacagtgta gtggctgacg ctcgcaacta    15660

tgctcgacgt aagagccggc gaaggcgcat tgccagacgc caccgagcta ccactgccat    15720

gcgagccgca agagctctgc tacgaagagc tagacgcgtg gggcgaagag ccatgcttag    15780

ggcggccaga cgtgcagctt cgggcgccag cgccggcagg tcccgcaggc aagcagccgc    15840

tgtcgcagcg gcgactattg ccgacatggc ccaatcgcga agaggcaatg tatactgggt    15900

gcgtgacgct gccaccggtc aacgtgtacc cgtgcgcacc cgtccccctc gcacttagaa    15960

gatactgagc agtctccgat gttgtgtccc agcggcgagg atgtccaagc gcaaatacaa    16020

ggaagaaatg ctgcaggtta tcgcacctga agtctacggc caaccgttga aggatgaaaa    16080

aaaaccccgc aaaatcaagc gggttaaaaa ggacaaaaaa gaagaggaag atggcgatga    16140

tgggctggcg gagtttgtgc gcgagtttgc cccacggcga cgcgtgcaat ggcgtgggcg    16200

caaagttcga catgtgttga gacctggaac ttcggtggtc tttacacccg gcgagcgttc    16260

aagcgctact tttaagcgtt cctatgatga ggtgtacggg gatgatgata ttcttgagca    16320

ggcggctgac cgattaggcg agtttgctta tggcaagcgt agtagaataa cttccaagga    16380

tgagacagtg tcgataccct tggatcatgg aaatcccacc cctagtctta aaccggtcac    16440

tttgcagcaa gtgttacccg taactccgcg aacaggtgtt aaacgcgaag gtgaagattt    16500

gtatcccact atgcaactga tggtacccaa acgccagaag ttggaggacg ttttggagaa    16560

agtaaaagtg gatccagata ttcaacctga ggttaaagtg agacccatta agcaggtagc    16620

gcctggtctg ggggtacaaa ctgtagacat taagattccc actgaaagta tggaagtgca    16680

aactgaaccc gcaaagccta ctgccacctc cactgaagtg caaacggatc catggatgcc    16740

catgcctatt acaactgacg ccgccggtcc cactcgaaga tcccgacgaa agtacggtcc    16800

agcaagtctg ttgatgccca attatgttgt acacccatct attattccta ctcctggtta    16860

ccgaggcact cgctactatc gcagccgaaa cagtacctcc cgccgtcgcc gcaagacacc    16920

tgcaaatcgc agtcgtcgcc gtagacgcac aagcaaaccg actcccggcg ccctggtgcg    16980

gcaagtgtac cgcaatggta gtgcggaacc tttgacactg ccgcgtgcgc gttaccatcc    17040

gagtatcatc acttaatcaa tgttgccgct gcctccttgc agatatggcc ctcacttgtc    17100

gccttcgcgt tcccatcact ggttaccgag gaagaaactc gcgccgtaga agagggatgt    17160

tgggacgcgg aatgcgacgc tacaggcgac ggcgtgctat ccgcaagcaa ttgcggggtg    17220

gttttttacc agccttaatt ccaattatcg ctgctgcaat tggcgcgata ccaggcatag    17280

cttccgtggc ggttcaggcc tcgcaacgac attgacattg gaaaaaaacg tataaataaa    17340

aaaaaaaaaa tacaatggac tctgacactc ctggtcctgt gactatgttt tcttagagat    17400

ggaagacatc aatttttcat ccttggctcc gcgacacggc acgaagccgt acatgggcac    17460

ctggagcgac atcggcacga gccaactgaa cgggggcgcc ttcaattgga gcagtatctg    17520

gagcgggctt aaaaattttg gctcaaccat aaaaacatac gggaacaaag cttggaacag    17580

cagtacagga caggcgctta gaaataaact taaagaccag aacttccaac aaaaagtagt    17640

cgatgggata gcttccggca tcaatggagt ggtagatttg gctaaccagg ctgtgcagaa    17700

aaagataaac agtcgtttgg acccgccgcc agcaacccca ggtgaaatgc aagtggagga    17760

agaaattcct ccgccagaaa aacgaggcga caagcgtccg cgtcccgatt tggaagagac    17820

gctggtgacg cgcgtagatg aaccgccttc ttatgaggaa gcaacgaagc ttggaatgcc    17880

caccactaga ccgatagccc caatggccac cggggtgatg aaaccttctc agttgcatcg    17940

acccgtcacc ttggatttgc cccctccccc tgctgctact gctgtacccg cttctaagcc    18000

tgtcgctgcc ccgaaaccag tcgccgtagc caggtcacgt cccgggggcg ctcctcgtcc    18060

aaatgcgcac tggcaaaata ctctgaacag catcgtgggt ctaggcgtgc aaagtgtaaa    18120

acgccgtcgc tgcttttaat taaatatgga gtagcgctta acttgcctat ctgtgtatat    18180

gtgtcattac acgccgtcac agcagcagag gaaaaaagga agaggtcgtg cgtcgacgct    18240

gagttacttt caagatggcc accccatcga tgctgcccca atgggcatac atgcacatcg    18300

ccggacagga tgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag    18360

acacctactt caatctggga aataagttta gaaatcccac cgtagcgccg acccacgatg    18420

tgaccaccga ccgtagccag cggctcatgt tgcgcttcgt gcccgttgac cgggaggaca    18480

atacatactc ttacaaagtg cggtacaccc tggccgtggg cgacaacaga gtgctggata    18540

tggccagcac gttctttgac attaggggtg tgttggacag aggtcccagt ttcaaaccct    18600

attctggtac ggcttacaac tccctggctc ctaaaggcgc tccaaataca tctcagtgga    18660

ttgcagaagg tgtaaaaaat acaactggtg aggaacacgt aacagaagag gaaaccaata    18720

ctactactta cacttttggc aatgctcctg taaaagctga agctgaaatt acaaaagaag    18780

gactcccagt aggtttggaa gtttcagatg aagaaagtaa accgatttat gctgataaaa    18840

catatcagcc agaacctcag ctgggagatg aaacttggac tgaccttgat ggaaaaaccg    18900

aaaagtatgg aggcagggct ctcaaacccg atactaagat gaaaccatgc tacgggtcct    18960

ttgccaaacc tactaatgtg aaaggcggtc aggcaaaaca aaaaacaacg gagcagccaa    19020

atcagaaagt cgaatatgat atcgacatgg agttttttga tgcggcatcg cagaaaacaa    19080

acttaagtcc taaaattgtc atgtatgcag aaaatgtaaa tttggaaact ccagacactc    19140

atgtagtgta caaacctgga acagaagaca caagttccga agctaatttg ggacaacaat    19200

ctatgcccaa cagacccaac tacattggct tcagagataa ctttattgga cttatgtact    19260

ataacagtac tggtaacatg ggggtgctgg ctggtcaagc gtctcagtta aatgcagtgg    19320

ttgacttgca ggacagaaac acagaacttt cttaccaact cttgcttgac tctctgggcg    19380

acagaaccag atactttagc atgtggaatc aggctgtgga cagttatgat cctgatgtac    19440

gtgttattga aaatcatggt gtggaagatg aacttcccaa ctactgtttt ccactggacg    19500

gcataggtgt tccaacaacc agttacaaat caatagttcc aaatggagac aatgcgccta    19560

attggaagga acctgaagta aatggaacaa gtgagatcgg acagggtaat ttgtttgcca    19620

tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat    19680

atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca    19740

cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca    19800

ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta    19860

acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca    19920

tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca    19980

cttatgagtg gaactttagg aaggatgtga acatggttct acagagttcc ctcggtaacg    20040

acctgcgggt agatggcgcc agcatcagtt tcacgagcat caacctctat gctacttttt    20100

tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg    20160

atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg    20220

caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat    20280

ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctactttg    20340

tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga    20400

aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc    20460

ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca    20520

acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg    20580

gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc    20640

ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac    20700

cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgccaaggtc    20760

aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta    20820

cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctcg agcaacttca    20880

tgtctatggg ggcccttaca gacttgggac agaatatgct ctatgccaac tcagctcatg    20940

ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct    21000

tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct    21060

acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc    21120

aaatagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca    21180

gagccattgt ccaagacctg ggttgcggac cctatttttt gggaacctac gataagcgct    21240

tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg    21300

agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc    21360

tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg    21420

agggtctcct gcgccgcagc gctcttgcta ccaaggaccg ctgtattacg ctggaaaaat    21480

ctacccagac cgtgcagggt ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc    21540

ttcacgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc    21600

taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca    21660

atcaaaaagc actctaccat tttcttaata cccattcgcc ttattttcgc tcccatcgta    21720

cacacatcga aagggccact gcgttcgacc gtatggatgt tcaataatga ctcatgtaaa    21780

caacgtgttc aataaacatc actttatttt tttacatgta tcaaggctct gcattactta    21840

tttatttaca agtcgaatgg gttctgacga gaatcagaat gacccgcagg cagtgatacg    21900

ttgcggaact gatacttggg ttgccacttg aattcgggaa tcaccaactt gggaaccggt    21960

atatcgggca ggatgtcact ccacagcttt ctggtcagct gcaaagctcc aagcaggtca    22020

ggagccgaaa tcttgaaatc acaattagga ccagtgcttt gagcgcgaga gttgcggtac    22080

accggattgc agcactgaaa caccatcagc gacggatgtc tcacgcttgc cagcacggtg    22140

ggatctgcaa tcatgcccac atccagatct tcagcattgg caatgctgaa cggggtcatc    22200

ttgcaggtct gcctacccat ggcgggcacc caattaggct tgtggttgca atcgcagtgc    22260

agggggatca gtatcatctt ggcctgatcc tgtctgattc ctggatacac ggctctcatg    22320

aaagcatcat attgcttgaa agcctgctgg gctttactac cctcggtata aaacatcccg    22380

caggacctgc tcgaaaactg gttagctgca cagccggcat cattcacaca gcagcgggcg    22440

tcattgttag ctatttgcac cacacttctg ccccagcggt tttgggtgat tttggttcgc    22500

tcgggattct cctttaaggc tcgttgtccg ttctcgctgg ccacatccat ctcgataatc    22560

tgctccttct gaatcataat attgccatgc aggcacttca gcttgccctc ataatcattg    22620

cagccatgag gccacaacgc acagcctgta cattcccaat tatggtgggc gatctgagaa    22680

aaagaatgta tcattccctg cagaaatctt cccatcatcg tgctcagtgt cttgtgacta    22740

gtgaaagtta actggatgcc tcggtgctcc tcgtttacgt actggtgaca gatgcgcttg    22800

tattgttcgt gttgctcagg cattagttta aaagaggttc taagttcgtt atccagcctg    22860

tacttctcca tcagcagaca catcacttcc atgcctttct cccaagcaga caccaggggc    22920

aagctaatcg gattcttaac agtgcaggca gcagctcctt tagccagagg gtcatcttta    22980

gcgatcttct caatgcttct tttgccatcc ttctcaacga tgcgcacggg cgggtagctg    23040

aaacccactg ctacaagttg cgcctcttct ctttcttctt cgctgtcttg actgatgtct    23100

tgcatgggga tatgtttggt cttccttggc ttctttttgg ggggtatcgg aggaggagga    23160

ctgtcgctcc gttccggaga cagggaggat tgtgacgttt cgctcaccat taccaactga    23220

ctgtcggtag aagaacctga ccccacacgg cgacaggtgt ttctcttcgg gggcagaggt    23280

ggaggcgatt gcgaagggct gcggtccgac ctggaaggcg gatgactggc agaacccctt    23340

ccgcgttcgg gggtgtgctc cctgtggcgg tcgcttaact gatttccttc gcggctggcc    23400

attgtgttct cctaggcaga gaaacaacag acatggaaac tcagccattg ctgtcaacat    23460

cgccacgagt gccatcacat ctcgtcctca gcgacgagga aaaggagcag agcttaagca    23520

ttccaccgcc cagtcctgcc accacctcta ccctagaaga taaggaggtc gacgcatctc    23580

atgacatgca gaataaaaaa gcgaaagagt ctgagacaga catcgagcaa gacccgggct    23640

atgtgacacc ggtggaacac gaggaagagt tgaaacgctt tctagagaga gaggatgaaa    23700

actgcccaaa acaacgagca gataactatc accaagatgc tggaaatagg gatcagaaca    23760

ccgactacct catagggctt gacggggaag acgcgctcct taaacatcta gcaagacagt    23820

cgctcatagt caaggatgca ttattggaca gaactgaagt gcccatcagt gtggaagagc    23880

tcagccgcgc ctacgagctt aacctctttt cacctcgtac tccccccaaa cgtcagccaa    23940

acggcacctg cgagccaaat cctcgcttaa acttttatcc agcttttgct gtgccagaag    24000

tactggctac ctatcacatc ttttttaaaa atcaaaaaat tccagtctcc tgccgcgcta    24060

atcgcacccg cgccgatgcc ctactcaatc tgggacctgg ttcacgctta cctgatatag    24120

cttccttgga agaggttcca aagatcttcg agggtctggg caataatgag actcgggccg    24180

caaatgctct gcaaaaggga gaaaatggca tggatgagca tcacagcgtt ctggtggaat    24240

tggaaggcga taatgccaga ctcgcagtac tcaagcgaag catcgaggtc acacacttcg    24300

catatcccgc tgtcaacctg ccccctaaag tcatgacggc ggtcatggac cagttactca    24360

ttaagcgcgc aagtcccctt tcagaagaca tgcatgaccc agatgcctgt gatgagggta    24420

aaccagtggt cagtgatgag cagctaaccc gatggctggg caccgactct cccagggatt    24480

tggaagagcg tcgcaagctt atgatggccg tggtgctggt taccgtagaa ctagagtgtc    24540

tccgacgttt ctttaccgat tcagaaacct tgcgcaaact cgaagagaat ctgcactaca    24600

cttttagaca cggctttgtg cggcaggcat gcaagatatc taacgtggaa ctcaccaacc    24660

tggtttccta catgggtatt ctgcatgaga atcgcctagg acaaagcgtg ctgcacagca    24720

ccctgaaggg ggaagcccgc cgtgattaca tccgcgattg tgtctatctg tacctgtgcc    24780

acacgtggca aaccggcatg ggtgtatggc agcaatgttt agaagaacag aacttgaaag    24840

agcttgacaa gctcttacag aaatctctta aggttctgtg gacagggttc gacgagcgca    24900

ccgtcgcttc cgacctggca gacctcatct tcccagagcg tctcagggtt actttgcgaa    24960

acggattgcc tgactttatg agccagagca tgcttaacaa ttttcgctct ttcatcctgg    25020

aacgctccgg tatcctgccc gccacctgct gcgcactgcc ctccgacttt gtgcctctca    25080

cctaccgcga gtgccccccg ccgctatgga gtcactgcta cctgttccgt ctggccaact    25140

atctctccta ccactcggat gtgatcgagg atgtgagcgg agacggcttg ctggagtgtc    25200

actgccgctg caatctgtgc acgccccacc ggtccctagc ttgcaacccc cagttgatga    25260

gcgaaaccca gataataggc acctttgaat tgcaaggccc cagcagccaa ggcgatgggt    25320

cttctcctgg gcaaagttta aaactgaccc cgggactgtg gacctccgcc tacttgcgca    25380

agtttgctcc ggaagattac cacccctatg aaatcaagtt ctatgaggac caatcacagc    25440

ctccaaaggc cgaactttcg gcctgcgtca tcacccaggg ggcaattctg gcccaattgc    25500

aagccatcca aaaatcccgc caagaatttc tactgaaaaa gggtaagggg gtctaccttg    25560

acccccagac cggcgaggaa ctcaacacaa ggttccctca ggatgtccca acgacgagaa    25620

aacaagaagt tgaaggtgca gccgccgccc ccagaagata tggaggaaga ttgggacagt    25680

caggcagagg aggcggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag    25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg    25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt    25860

cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc    25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc    25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat    26040

ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat    26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa    26160

accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac    26220

agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc    26280

catcttccag cagagtcggg gtcaagagca ggaactgaaa ataaaaaacc gatctctgcg    26340

ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga    26400

ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac    26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca    26520

cgccttacat gtggagttat caaccccaaa tgggattggc ggcaggcgcc tcccaggact    26580

actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata    26640

tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc    26700

aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca    26760

ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc    26820

agttagctgg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga    26880

tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac    26940

gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg    27000

ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc    27060

aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc    27120

attacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg    27180

attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg    27240

ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca    27300

ccctcaaggt ccggcccacg gagtgcggat ttctatcgaa ggcaaaatag actctcgcct    27360

gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt    27420

ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg    27480

tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg    27540

gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct    27600

ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta    27660

ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg    27720

tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct    27780

acctatacac accttgcttc actttcttag tggtgttgtg gtattggttt aaaaaatggg    27840

gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga    27900

tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg    27960

catctgtgga gttcatcgcc tctcttacga acttggcccc caacgacaaa aatttacctg    28020

catggtggga atcaacccca tagttatcac ccagcaaagt ggagatacta agggttgcat    28080

tcactgctcc tgcgattcca tcgagtgcac ctacaccctg ctgaagaccc tatgcggcct    28140

aagagacctg ctaccaatga attaaaaaat gattaataaa aaatcactta cttgaaatca    28200

gcaataaggt ctctgttgaa attttctccc agcagcacct cacttccctc ttcccaactc    28260

tggtattcta aaccccgttc agcggcatac tttctccata ctttaaaggg gatgtcaaat    28320

tttagctcct ctcctgtacc cacaatcttc atgtctttct tcccagatga ccaagagagt    28380

ccggctcagt gactccttca accctgtcta cccctatgaa gatgaaagca cctcccaaca    28440

cccctttata aacccagggt ttatttcccc aaatggcttc acacaaagcc caaacggagt    28500

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28560

gggaggggga cttacagtgg atgacaccaa cggttttttg aaagaaaaca taagtgccac    28620

cacaccactc gttaagactg gtcactctat aggtttacca ctaggagccg gattgggaac    28680

gaatgaaaat aaactttgta tcaaattagg acaaggactt acattcaatt caaacaacat    28740

ttgcattgat gacaatatta acaccttatg gacaggagtc aaccccaccg aagccaactg    28800

tcaaatcatg aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac    28860

tggagcacta gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct    28920

aactacacac agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt    28980

actaactaga ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc    29040

tactggtgcc attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa    29100

tgataattct agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga    29160

tcgcactgct tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga    29220

gacatcatat tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca    29280

aacctctgct acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga    29340

ctgacaaata aagtttaact tgtttatttg aaaatcaatt cacaaaatcc gagtagttat    29400

tttgcctccc ccttcccatt taacagaata caccaatctc tccccacgca cagctttaaa    29460

catttggata ccattagata tagacatggt tttagattcc acattccaaa cagtttcaga    29520

gcgagccaat ctggggtcag tgatagataa aaatccatcg ggatagtctt ttaaagcgct    29580

ttcacagtcc aactgctgcg gatgcgactc cggagtctgg atcacggtca tctggaagaa    29640

gaacgatggg aatcataatc cgaaaacggt atcggacgat tgtgtctcat caaacccaca    29700

agcagccgct gtctgcgtcg ctccgtgcga ctgctgttta tgggatcagg gtccacagtg    29760

tcctgaagca tgattttaat agcccttaac atcaactttc tggtgcgatg cgcgcagcaa    29820

cgcattctga tttcactcaa atctttgcag taggtacaac acattattac aatattgttt    29880

aataaaccat aattaaaagc gctccagcca aaactcatat ctgatataat cgcccctgca    29940

tgaccatcat accaaagttt aatataaatt aaatgacgtt ccctcaaaaa cacactaccc    30000

acatacatga tctcttttgg catgtgcata ttaacaatct gtctgtacca tggacaacgt    30060

tggttaatca tgcaacccaa tataaccttc cggaaccaca ctgccaacac cgctccccca    30120

gccatgcatt gaagtgaacc ctgctgatta caatgacaat gaagaaccca attctctcga    30180

ccgtgaatca cttgagaatg aaaaatatct atagtggcac aacatagaca taaatgcatg    30240

catcttctca taatttttaa ctcctcagga tttagaaaca tatcccaggg aataggaagc    30300

tcttgcagaa cagtaaagct ggcagaacaa ggaagaccac gaacacaact tacactatgc    30360

atagtcatag tatcacaatc tggcaacagc gggtggtctt cagtcataga agctcgggtt    30420

tcattttcct cacaacgtgg taactgggct ctggtgtaag ggtgatgtct ggcgcatgat    30480

gtcgagcgtg cgcgcaacct tgtcataatg gagttgcttc ctgacattct cgtattttgt    30540

atagcaaaac gcggccctgg cagaacacac tcttcttcgc cttctatcct gccgcttagc    30600

gtgttccgtg tgatagttca agtacaacca cactcttaag ttggtcaaaa gaatgctggc    30660

ttcagttgta atcaaaactc catcgcatct aatcgttctg aggaaatcat ccaagcaatg    30720

caactggatt gtgtttcaag caggagagga gagggaagag acggaagaac catgttaatt    30780

tttattccaa acgatctcgc agtacttcaa attgtagatc gcgcagatgg catctctcgc    30840

ccccactgtg ttggtgaaaa agcacagcta gatcaaaaga aatgcgattt tcaaggtgct    30900

caacggtggc ttccagcaaa gcctccacgc gcacatccaa gaacaaaaga ataccaaaag    30960

aaggagcatt ttctaactcc tcaatcatca tattacattc ctgcaccatt cccagataat    31020

tttcagcttt ccagccttga attattcgtg tcagttcttg tggtaaatcc aatccacaca    31080

ttacaaacag gtcccggagg gcgccctcca ccaccattct taaacacacc ctcataatga    31140

caaaatatct tgctcctgtg tcacctgtag cgaattgaga atggcaacat caattgacat    31200

gcccttggct ctaagttctt ctttaagttc tagttgtaaa aactctctca tattatcacc    31260

aaactgctta gccagaagcc ccccgggaac aagagcaggg gacgctacag tgcagtacaa    31320

gcgcagacct ccccaattgg ctccagcaaa aacaagattg gaataagcat attgggaacc    31380

gccagtaata tcatcgaagt tgctggaaat ataatcaggc agagtttctt gtaaaaattg    31440

aataaaagaa aaatttgcca aaaaaacatt caaaacctct gggatgcaaa tgcaataggt    31500

taccgcgctg cgctccaaca ttgttagttt tgaattagtc tgcaaaaata aaaaaaaaaa    31560

caagcgtcat atcatagtag cctgacgaac agatggataa atcagtcttt ccatcacaag    31620

acaagccaca gggtctccag ctcgaccctc gtaaaacctg tcatcatgat taaacaacag    31680

caccgaaagt tcctcgcggt gaccagcatg aataattctt gatgaagcat acaatccaga    31740

catgttagca tcagttaacg agaaaaaaca gccaacatag cctttgggta taattatgct    31800

taatcgtaag tatagcaaag ccacccctcg cggatacaaa gtaaaaggca caggagaata    31860

aaaaatataa ttatttctct gctgctgttc aggcaacgtc gcccccggtc cctctaaata    31920

cacatacaaa gcctcatcag ccatggctta ccagacaaag tacagcgggc acacaaagca    31980

caagctctaa agtgactctc caacctctcc acaatatata tatacacaag ccctaaactg    32040

acgtaatggg agtaaagtgt aaaaaatccc gccaaaccca acacacaccc cgaaactgcg    32100

tcaccaggga aaagtacagt ttcacttccg caatcccaac aggcgtaact tcctctttct    32160

cacggtacgt gatatcccac taacttgcaa cgtcattttc ccacggtcgc accgcccctt    32220

ttagccgtta accccacagc caatcaccac acgatccaca ctttttaaaa tcacctcatt    32280

tacatattgg caccattcca tctataaggt atattatata gataga                   32326


<210>  39
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bx DNA sequence corresponding to and including bp 28166-28366 of 
       the EnAd genome

<400>  39
aaaatgatta ataaaaaatc acttacttga aatcagcaat aaggtctctg ttgaaatttt       60

ctcccagcag cacctcactt ccctcttccc aactctggta ttctaaaccc cgttcagcgg      120

catactttct ccatacttta aaggggatgt caaattttag ctcctctcct gtacccacaa      180

tcttcatgtc tttcttccca g                                                201


<210>  40
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  By DNA sequence corresponding to and including bp 29345-29379 of 
       the EnAd genome

<400>  40
caaataaagt ttaacttgtt tatttgaaaa tcaat                                  35


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His Tag

<400>  41

His His His His His His 
1               5       


<210>  42
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Splice acceptor

<400>  42
tttctctctt cagg                                                         14


<210>  43
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 poly Adenylation sequence

<400>  43
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


<210>  44
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EpCam BiTE nucleic acid sequence (OKT3)

<400>  44
atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt gcatagcgaa       60

ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa ggtcaccatg      120

tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta cctcacgtgg      180

tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag cacccgcgag      240

tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac cctaaccatc      300

agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta ctcgtaccct      360

ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag cggcggggga      420

ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc cgaactggtc      480

cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt taccaattac      540

tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg cgacatcttc      600

ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac tctgactgcc      660

gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga agacagcgcg      720

gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg gggacaagga      780

actaccgtga ccgtctcctc cggcggcggt ggaagccagg tgcagctgca gcagtctggg      840

gctgaactgg caagacctgg ggcctcagtg aagatgtcct gcaaggcttc tggctacacc      900

tttactaggt acacgatgca ctgggtaaaa cagaggcctg gacagggtct ggaatggatt      960

ggatacatta atcctagccg tggttatact aattacaatc agaagttcaa ggacaaggcc     1020

acattgacta cagacaaatc ctccagcaca gcctacatgc aactgagcag cctgacatct     1080

gaggactctg cagtctatta ctgtgcaaga tattatgatg atcattactg ccttgactac     1140

tggggccaag gcaccactct cacagtctcc tcaggtggcg gtggctcggg cggtggtgga     1200

tctggtggcg gcggatctga tatcgtgctc actcagtctc cagcaatcat gtctgcatct     1260

ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgaactgg     1320

taccagcaga agtcaggcac ctcccccaaa agatggattt atgacacatc caaactggct     1380

tctggagtcc ctgctcactt caggggcagt gggtctggga cctcttactc tctcacaatc     1440

agcggcatgg aggctgaaga tgctgccact tattactgcc agcagtggag tagtaaccca     1500

ttcacgttcg gctcggggac aaagttggaa ataaaccgg                            1539


<210>  45
<211>  1551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAP BiTE nucleic acid sequence (OKT3)

<400>  45
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca ggtgcagctg      840

cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc ctgcaaggct      900

tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc tggacagggt      960

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa tcagaagttc     1020

aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat gcaactgagc     1080

agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga tgatcattac     1140

tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg cggtggctcg     1200

ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc tccagcaatc     1260

atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc aagtgtaagt     1320

tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca     1380

tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg gacctcttac     1440

tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg     1500

agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg g              1551


<210>  46
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAP BiTE nucleic acid sequence (aCD3)

<400>  46
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaga tgtgcaactc      840

gtgcagtccg gtgcggaagt gaaaaagccg ggcgcgagcg tcaaagtgtc atgcaaggcg      900

tcaggatata cgtttactag atacactatg cactgggtgc gccaggcacc tggtcagggc      960

cttgaatgga tcggctacat caatccgtcg agaggctaca ctaattacgc ggactcagtc     1020

aaagggcgct tcacgattac gaccgacaag tccacctcga ctgcatacat ggaactgtcc     1080

tcgctgagaa gcgaggacac cgctacttac tactgcgcta gatactacga tgatcactac     1140

tgcctcgatt actggggcca gggaaccact gtcacggtgt catcgggaga gggcacctca     1200

accggatcag ggggatcggg aggctcgggc ggcgcagacg acatcgtcct gacccagtcg     1260

cccgccacct tgtcgctgtc cccaggagaa agagcgaccc tgtcatgccg ggcgtcgcaa     1320

agcgtgagct atatgaattg gtatcagcag aagccaggaa aggcgccgaa gagatggatc     1380

tacgacacct ccaaggtcgc ttcaggtgtc ccggctagat tctcaggatc gggatcagga     1440

acggactact ccctgaccat caattcactg gaagcagaag atgcggccac ctactactgt     1500

cagcagtggt cctccaaccc gctgactttc ggaggcggaa ctaaggtcga gatcaag        1557


<210>  47
<211>  1856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-611 Transgene cassette

<400>  47
caggcccacc atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt       60

gcatagcgaa ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa      120

ggtcaccatg tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta      180

cctcacgtgg tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag      240

cacccgcgag tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac      300

cctaaccatc agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta      360

ctcgtaccct ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag      420

cggcggggga ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc      480

cgaactggtc cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt      540

taccaattac tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg      600

cgacatcttc ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac      660

tctgactgcc gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga      720

agacagcgcg gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg      780

gggacaagga actaccgtga ccgtctcctc cggcggcggt ggaagccagg tgcagctgca      840

gcagtctggg gctgaactgg caagacctgg ggcctcagtg aagatgtcct gcaaggcttc      900

tggctacacc tttactaggt acacgatgca ctgggtaaaa cagaggcctg gacagggtct      960

ggaatggatt ggatacatta atcctagccg tggttatact aattacaatc agaagttcaa     1020

ggacaaggcc acattgacta cagacaaatc ctccagcaca gcctacatgc aactgagcag     1080

cctgacatct gaggactctg cagtctatta ctgtgcaaga tattatgatg atcattactg     1140

ccttgactac tggggccaag gcaccactct cacagtctcc tcaggtggcg gtggctcggg     1200

cggtggtgga tctggtggcg gcggatctga tatcgtgctc actcagtctc cagcaatcat     1260

gtctgcatct ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta     1320

catgaactgg taccagcaga agtcaggcac ctcccccaaa agatggattt atgacacatc     1380

caaactggct tctggagtcc ctgctcactt caggggcagt gggtctggga cctcttactc     1440

tctcacaatc agcggcatgg aggctgaaga tgctgccact tattactgcc agcagtggag     1500

tagtaaccca ttcacgttcg gctcggggac aaagttggaa ataaaccggc atcaccatca     1560

ccatcaccac catcaccatt aggctagctt gactgactga gatacagcgt accttcagct     1620

cacagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa     1680

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg     1740

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt     1800

gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtagtcgtc agctat         1856


<210>  48
<211>  1868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-612 Transgene cassette

<400>  48
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gcatcaccat caccatcacc accatcacca ttaggctagc ttgactgact gagatacagc     1620

gtaccttcag ctcacagaca tgataagata cattgatgag tttggacaaa ccacaactag     1680

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     1740

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     1800

tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtagtcg     1860

tcagctat                                                              1868


<210>  49
<211>  1878
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-613 Transgene cassette

<400>  49
tttctctctt caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg       60

ctaccggagt ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac      120

tgggagagcg ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc      180

agaaaaacta cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct      240

tctgggcctc cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa      300

ctgactttac tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc      360

agcagtattt ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag      420

ggggcggcag cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat      480

ccggagccga agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct      540

acaccttcac tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt      600

ggatcggcgg gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc      660

gggtgactat caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca      720

gatcggagga caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg      780

aaggacatgc gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg      840

gcggttcaca ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag      900

tgaagatgtc ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa      960

aacagaggcc tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata     1020

ctaattacaa tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca     1080

cagcctacat gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa     1140

gatattatga tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct     1200

cctcaggtgg cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc     1260

tcactcagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca     1320

gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca     1380

aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca     1440

gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca     1500

cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg     1560

aaataaaccg gcatcaccat caccatcacc accatcacca ttaggctagc ttgactgact     1620

gagatacagc gtaccttcag ctcacagaca tgataagata cattgatgag tttggacaaa     1680

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     1740

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     1800

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     1860

gtggtagtcg tcagctat                                                   1878


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Restriction site insert (Bx)

<400>  50
gcggccgcta tggccggcc                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Restriction site insert (By)

<400>  51
gcgatcgcta ccctgcagg                                                    19


<210>  52
<211>  572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter sequence

<400>  52
agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac       60

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      120

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      180

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      240

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      300

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atgctgatgc      360

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      420

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      480

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      540

tctatataag cagagctggt ttagtgaacc gt                                    572


<210>  53
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK promoter sequence

<400>  53
ctaccgggta ggggaggcgc ttttcccaag gcagtctgga gcatgcgctt tagcagcccc       60

gctgggcact tggcgctaca caagtggcct ctggcctcgc acacattcca catccaccgg      120

taggcgccaa ccggctccgt tctttggtgg ccccttcgcg ccaccttcta cccctcccct      180

agtcaggaag ttcccccccg ccccgcagct cgcgtcatgc aggacgtgac aaatggaagt      240

agcacgtctc actagtctcg tgcaaatgga cagcaccgct gagcaatgga agcgggtagg      300

cccttggggc agcggccaat agcagctttg ctccttcgct ttctgggctc agaggctggg      360

aaggggtggg tccgggggcg ggctcagggg cgggctcagg ggcggggcgg gcgcccgaag      420

gtcctccgga ggcccggcat tccgcacgct tcaaaagcgc acgtctgccg cgctgttctc      480

ttcttcctca tctccgggcc tttcg                                            505


<210>  54
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CBA promoter sequence

<400>  54
gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc cccaccccca       60

attttgtatt tatttatttt ttaattattt tatgcagcga tgggggcggg gggggggggg      120

gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc      180

ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg      240

gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgt tgccttcgcc      300

ccgtgccccg ctccgcgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact      360

cccacag                                                                367


<210>  55

<400>  55
000

<210>  56
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice acceptor (SA) DNA sequence

<400>  56
cctttctctc ttcagg                                                       16


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  branched splice acceptor (bSA) DNA sequence

<400>  57
tgctaatcct ttctctcttc agg                                               23


<210>  58

<400>  58
000

<210>  59
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Example of start codon


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  R is adenine or guanine

<400>  59
gccgccrcca ugg                                                          13


<210>  60
<211>  551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Internal Ribosome Entry Sequence (IRES)

<400>  60
cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc       60

caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac      120

gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt      180

gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg      240

caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata      300

agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga      360

aagagtcaaa tggctcccct caagcgtatt caacaagggg ctgaaggatg cccagaaggt      420

accccattgt atgggatctg atctggggcc tcggtgcaca tgcttttcat gtgtttagtc      480

gaggttaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca      540

cgatgataat a                                                           551


<210>  61
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  61

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  62
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide

<400>  62

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  63
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide

<400>  63

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  64
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide

<400>  64

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  65
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polyadenylation (polyA) sequence

<400>  65
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


<210>  66
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  66

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  67
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  67

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  68
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFN gamma  amino acid sequence

<400>  68

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  69
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFN alpha amino acid sequence

<400>  69

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  70
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF alpha amino acid sequence

<400>  70

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  71
<211>  5288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence corresponding to E2B region of the EnAd genome (bp 
       10355-5068)

<400>  71
ctatggcatc tcgatccagc agacctcctc gtttcgcggg tttggacggc tcctggaata       60

gggtatgaga cgatgggcgt ccagcgctgc cagggttcgg tccttccagg gtctcagtgt      120

tcgagtcagg gttgtttccg tcacagtgaa ggggtgtgcg cctgcttggg cgcttgccag      180

ggtgcgcttc agactcatcc tgctggtcga aaacttctgt cgcttggcgc cctgtatgtc      240

ggccaagtag cagtttacca tgagttcgta gttgagcgcc tcggctgcgt ggcctttggc      300

gcggagctta cctttggaag ttttcttgca taccgggcag tataggcatt tcagcgcata      360

caacttgggc gcaaggaaaa cggattctgg ggagtatgca tctgcgccgc aggaggcgca      420

aacagtttca cattccacca gccaggttaa atccggttca ttggggtcaa aaacaagttt      480

tccgccatat tttttgatgc gtttcttacc tttggtctcc atgagttcgt gtcctcgttg      540

agtgacaaac aggctgtccg tgtccccgta gactgatttt acaggcctct tctccagtgg      600

agtgcctcgg tcttcttcgt acaggaactc tgaccactct gatacaaagg cgcgcgtcca      660

ggccagcaca aaggaggcta tgtgggaggg gtagcgatcg ttgtcaacca gggggtccac      720

cttttccaaa gtatgcaaac acatgtcacc ctcttcaaca tccaggaatg tgattggctt      780

gtaggtgtat ttcacgtgac ctggggtccc cgctgggggg gtataaaagg gggcggttct      840

ttgctcttcc tcactgtctt ccggatcgct gtccaggaac gtcagctgtt ggggtaggta      900

ttccctctcg aaggcgggca tgacctctgc actcaggttg tcagtttcta agaacgagga      960

ggatttgata ttgacagtgc cggttgagat gcctttcatg aggttttcgt ccatctggtc     1020

agaaaacaca atttttttat tgtcaagttt ggtggcaaat gatccataca gggcgttgga     1080

taaaagtttg gcaatggatc gcatggtttg gttcttttcc ttgtccgcgc gctctttggc     1140

ggcgatgttg agttggacat actcgcgtgc caggcacttc cattcgggga agatagttgt     1200

taattcatct ggcacgattc tcacttgcca ccctcgatta tgcaaggtaa ttaaatccac     1260

actggtggcc acctcgcctc gaaggggttc attggtccaa cagagcctac ctcctttcct     1320

agaacagaaa gggggaagtg ggtctagcat aagttcatcg ggagggtctg catccatggt     1380

aaagattccc ggaagtaaat ccttatcaaa atagctgatg ggagtggggt catctaaggc     1440

catttgccat tctcgagctg ccagtgcgcg ctcatatggg ttaaggggac tgccccatgg     1500

catgggatgg gtgagtgcag aggcatacat gccacagatg tcatagacgt agatgggatc     1560

ctcaaagatg cctatgtagg ttggatagca tcgcccccct ctgatacttg ctcgcacata     1620

gtcatatagt tcatgtgatg gcgctagcag ccccggaccc aagttggtgc gattgggttt     1680

ttctgttctg tagacgatct ggcgaaagat ggcgtgagaa ttggaagaga tggtgggtct     1740

ttgaaaaatg ttgaaatggg catgaggtag acctacagag tctctgacaa agtgggcata     1800

agattcttga agcttggtta ccagttcggc ggtgacaagt acgtctaggg cgcagtagtc     1860

aagtgtttct tgaatgatgt cataacctgg ttggtttttc ttttcccaca gttcgcggtt     1920

gagaaggtat tcttcgcgat ccttccagta ctcttctagc ggaaacccgt ctttgtctgc     1980

acggtaagat cctagcatgt agaactgatt aactgccttg taagggcagc agcccttctc     2040

tacgggtaga gagtatgctt gagcagcttt tcgtagcgaa gcgtgagtaa gggcaaaggt     2100

gtctctgacc atgactttga ggaattggta tttgaagtcg atgtcgtcac aggctccctg     2160

ttcccagagt tggaagtcta cccgtttctt gtaggcgggg ttgggcaaag cgaaagtaac     2220

atcattgaag agaatcttgc cggccctggg catgaaattg cgagtgatgc gaaaaggctg     2280

tggtacttcc gctcggttat tgataacctg ggcagctagg acgatctcgt cgaaaccgtt     2340

gatgttgtgt cctacgatgt ataattctat gaaacgcggc gtgcctctga cgtgaggtag     2400

cttactgagc tcatcaaagg ttaggtctgt ggggtcagat aaggcgtagt gttcgagagc     2460

ccattcgtgc aggtgaggat tcgctttaag gaaggaggac cagaggtcca ctgccagtgc     2520

tgtttgtaac tggtcccggt actgacgaaa atgccgtccg actgccattt tttctggggt     2580

gacgcaatag aaggtttggg ggtcctgccg ccagcgatcc cacttgagtt ttatggcgag     2640

gtcataggcg atgttgacga gccgctggtc tccagagagt ttcatgacca gcatgaaggg     2700

gattagctgc ttgccaaagg accccatcca ggtgtaggtt tccacatcgt aggtgagaaa     2760

gagcctttct gtgcgaggat gagagccaat cgggaagaac tggatctcct gccaccagtt     2820

ggaggaatgg ctgttgatgt gatggaagta gaactccctg cgacgcgccg agcattcatg     2880

cttgtgcttg tacagacggc cgcagtagtc gcagcgttgc acgggttgta tctcgtgaat     2940

gagttgtacc tggcttccct tgacgagaaa tttcagtggg aagccgaggc ctggcgattg     3000

tatctcgtgc tttactatgt tgtctgcatc ggcctgttca tcttctgtct cgatggtggt     3060

catgctgacg agccctcgcg ggaggcaagt ccagacctcg gcgcggcagg ggcggagctc     3120

gaggacgaga gcgcgcaggc tggagctgtc cagggtcctg agacgctgcg gactcaggtt     3180

agtaggcagt gtcaggagat taacttgcat gatcttttgg agggcgtgcg ggaggttcag     3240

atagtacttg atctcaacgg gtccgttggt ggagatgtcg atggcttgca gggttccgtg     3300

tcccttgggc gctaccaccg tgcccttgtt tttcattttg gacggcggtg gctctgttgc     3360

ttcttgcatg tttagaagcg gtgtcgaggg cgcgcaccgg gcggcagggg cggctcggga     3420

cccggcggca tggctggcag tggtacgtcg gcgccgcgcg cgggtaggtt ctggtactgc     3480

gccctgagaa gactcgcatg cgcgacgacg cggcggttga catcctggat ctgacgcctc     3540

tgggtgaaag ctaccggccc cgtgagcttg aacctgaaag agagttcaac agaatcaatc     3600

tcggtatcgt tgacggcggc ttgcctaagg atttcttgca cgtcaccaga gttgtcctgg     3660

taggcgatct ccgccatgaa ctgctcgatc tcttcctctt gaagatctcc gcggcccgct     3720

ctctcgacgg tggccgcgag gtcgttggag atgcgcccaa tgagttgaga gaatgcattc     3780

atgcccgcct cgttccagac gcggctgtag accacggccc ccacgggatc tctcgcgcgc     3840

atgaccacct gggcgaggtt gagctccacg tggcgggtga agaccgcata gttgcatagg     3900

cgctggaaaa ggtagttgag tgtggtggcg atgtgctcgg tgacgaagaa atacatgatc     3960

catcgtctca gcggcatctc gctgacatcg cccagagctt ccaagcgctc catggcctcg     4020

tagaagtcca cggcaaaatt aaaaaactgg gagtttcgcg cggacacggt caactcctct     4080

tccagaagac ggataagttc ggcgatggtg gtgcgcacct cgcgctcgaa agcccctggg     4140

atttcttcct caatctcttc ttcttccact aacatctctt cctcttcagg tggggctgca     4200

ggaggagggg gaacgcggcg acgccggcgg cgcacgggca gacggtcgat gaatctttca     4260

atgacctctc cgcggcggcg gcgcatggtt tcagtgacgg cgcggccgtt ctcgcgcggt     4320

cgcagagtaa aaacaccgcc gcgcatctcc ttaaagtggt gactgggagg ttctccgttt     4380

gggagggaga gggcgctgat tatacatttt attaattggc ccgtagggac tgcacgcaga     4440

gatctgatcg tgtcaagatc cacgggatct gaaaaccttt cgacgaaagc gtctaaccag     4500

tcacagtcac aaggtaggct gagtacggct tcttgtgggc gggggtggtt atgtgttcgg     4560

tctgggtctt ctgtttcttc ttcatctcgg gaaggtgaga cgatgctgct ggtgatgaaa     4620

ttaaagtagg cagttctaag acggcggatg gtggcgagga gcaccaggtc tttgggtccg     4680

gcttgctgga tacgcaggcg attggccatt ccccaagcat tatcctgaca tctagcaaga     4740

tctttgtagt agtcttgcat gagccgttct acgggcactt cttcctcacc cgttctgcca     4800

tgcatacgtg tgagtccaaa tccgcgcatt ggttgtacca gtgccaagtc agctacgact     4860

ctttcggcga ggatggcttg ctgtacttgg gtaagggtgg cttgaaagtc atcaaaatcc     4920

acaaagcggt ggtaagctcc tgtattaatg gtgtaagcac agttggccat gactgaccag     4980

ttaactgtct ggtgaccagg gcgcacgagc tcggtgtatt taaggcgcga ataggcgcgg     5040

gtgtcaaaga tgtaatcgtt gcaggtgcgc accagatact ggtaccctat aagaaaatgc     5100

ggcggtggtt ggcggtagag aggccatcgt tctgtagctg gagcgccagg ggcgaggtct     5160

tccaacataa ggcggtgata gccgtagatg tacctggaca tccaggtgat tcctgcggcg     5220

gtagtagaag cccgaggaaa ctcgcgtacg cggttccaaa tgttgcgtag cggcatgaag     5280

tagttcat                                                              5288


<210>  72
<211>  1548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM BiTE DNA coding sequence, with N-terminal signal 
       sequence and C-terminal deca-His affinity tag

<400>  72
atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt gcatagcgaa       60

ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa ggtcaccatg      120

tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta cctcacgtgg      180

tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag cacccgcgag      240

tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac cctaaccatc      300

agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta ctcgtaccct      360

ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag cggcggggga      420

ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc cgaactggtc      480

cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt taccaattac      540

tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg cgacatcttc      600

ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac tctgactgcc      660

gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga agacagcgcg      720

gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg gggacaagga      780

actaccgtga ccgtctcctc cggcggcggt ggaagcgatg tgcaactcgt gcagtccggt      840

gcggaagtga aaaagccggg cgcgagcgtc aaagtgtcat gcaaggcgtc aggatatacg      900

tttactagat acactatgca ctgggtgcgc caggcacctg gtcagggcct tgaatggatc      960

ggctacatca atccgtcgag aggctacact aattacgcgg actcagtcaa agggcgcttc     1020

acgattacga ccgacaagtc cacctcgact gcatacatgg aactgtcctc gctgagaagc     1080

gaggacaccg ctacttacta ctgcgctaga tactacgatg atcactactg cctcgattac     1140

tggggccagg gaaccactgt cacggtgtca tcgggagagg gcacctcaac cggatcaggg     1200

ggatcgggag gctcgggcgg cgcagacgac atcgtcctga cccagtcgcc cgccaccttg     1260

tcgctgtccc caggagaaag agcgaccctg tcatgccggg cgtcgcaaag cgtgagctat     1320

atgaattggt atcagcagaa gccaggaaag gcgccgaaga gatggatcta cgacacctcc     1380

aaggtcgctt caggtgtccc ggctagattc tcaggatcgg gatcaggaac ggactactcc     1440

ctgaccatca attcactgga agcagaagat gcggccacct actactgtca gcagtggtcc     1500

tccaacccgc tgactttcgg aggcggaact aaggtcgaga tcaagtag                  1548


<210>  73
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EpCAM BiTE protein sequence, with N-terminal signal sequence
       without C-terminal deca-His affinity tag

<400>  73

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
145                 150                 155                 160 


Arg Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
                165                 170                 175     


Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
    290                 295                 300                 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            420                 425                 430         


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
    450                 455                 460                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
465                 470                 475                 480 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys 
        515 


<210>  74
<211>  1560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-FAP BiTE DNA coding sequence, with N-terminal signal 
       sequence without C-terminal deca-His affinity tag

<400>  74
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaga tgtgcaactc      840

gtgcagtccg gtgcggaagt gaaaaagccg ggcgcgagcg tcaaagtgtc atgcaaggcg      900

tcaggatata cgtttactag atacactatg cactgggtgc gccaggcacc tggtcagggc      960

cttgaatgga tcggctacat caatccgtcg agaggctaca ctaattacgc ggactcagtc     1020

aaagggcgct tcacgattac gaccgacaag tccacctcga ctgcatacat ggaactgtcc     1080

tcgctgagaa gcgaggacac cgctacttac tactgcgcta gatactacga tgatcactac     1140

tgcctcgatt actggggcca gggaaccact gtcacggtgt catcgggaga gggcacctca     1200

accggatcag ggggatcggg aggctcgggc ggcgcagacg acatcgtcct gacccagtcg     1260

cccgccacct tgtcgctgtc cccaggagaa agagcgaccc tgtcatgccg ggcgtcgcaa     1320

agcgtgagct atatgaattg gtatcagcag aagccaggaa aggcgccgaa gagatggatc     1380

tacgacacct ccaaggtcgc ttcaggtgtc ccggctagat tctcaggatc gggatcagga     1440

acggactact ccctgaccat caattcactg gaagcagaag atgcggccac ctactactgt     1500

cagcagtggt cctccaaccc gctgactttc ggaggcggaa ctaaggtcga gatcaagtag     1560


<210>  75
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FAP BiTE amino acid sequence, with N-terminal signal 
       sequence without C-terminal deca-His affinity tag

<400>  75

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe 
                165                 170                 175     


Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        275                 280                 285             


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    290                 295                 300                 


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
305                 310                 315                 320 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr 
            340                 345                 350         


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser 
385                 390                 395                 400 


Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
                405                 410                 415     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            420                 425                 430         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    450                 455                 460                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys 
        515                 


<210>  76
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) BiTE DNA coding sequence, with N-terminal 
       signal sequence without C-terminal deca-His affinity tag

<400>  76
atgggttggt catgcatcat cctgtttctc gtcgcaactg cgaccggcgt gcattcggaa       60

ctggacatcg tgatgaccca ggcacctgca tcactggcag tgagcctggg acagagagcc      120

accatttcat gccgggccag caagagcgtg tcgtcatccg gatacaatta tctgcactgg      180

tatcagcaga aaccaggaca acctccaaag ctactcatct acctggcgtc gaacctcgaa      240

tcgggcgtcc cagctagatt ctcagggagc ggttcgggaa ccgatttcac cctgaacatc      300

caccctgtgg aggaggaaga cgcggcaacg tactattgcc agcattcccg cgagttccct      360

ctcactttcg gtgcgggaac taagctggag atcaagtcca gcggcggcgg aggtagcggt      420

ggaggtggcg gaggaagctc ccggtcgtcg ctggaggtgc agctgcaaca atccggcccg      480

gaactggtca agccaggcgc atccgtcaag atttcatgca agacctcggg gtacaccttc      540

accgggtaca cgatgcattg ggtcaggcag agccacggca agtccctgga atggatcgga      600

ggaatcaacc ccaaaaacgg cggcatcatc tacaaccaaa agttccaggg aaaagccact      660

ctgaccgtgg acaagtcgtc gagcacggcc agcatggagc tgcggtccct cacttccgac      720

gactcagccg tgtattactg cgcgagacgg gtctacgatg actacccata ctactacgct      780

atggactact ggggacaagg aaccagcgtg accgtctcat cggcgaaaac tactccgccg      840

tcggtgacgt cgggaggtgg tggaagcgac gtgcagctcg tccagtcggg tgccgaggtg      900

aagaagccag gagcctccgt gaaggtctcg tgcaaagcca gcggctacac ttttactagg      960

tacactatgc actgggtgcg gcaagcgccg ggacaaggtc tggagtggat cggatacatc     1020

aatccgtcgc ggggatacac taattacgcg gactccgtca agggacggtt tactatcact     1080

acggataagt ccactagcac cgcctacatg gaactgtcct cgctgcggtc ggaagacact     1140

gcgacctact actgcgctag atattacgat gaccactact gcctcgacta ttgggggcag     1200

ggcactacgg tcaccgtctc gtcgggagaa ggaacctcaa ctggatcggg cggatcggga     1260

ggctccggag gagccgacga catcgtgctt acccagtcgc ctgcgaccct gtccctgtcc     1320

ccaggagaga gagcgactct ttcatgcagg gcttcccaat cagtctccta catgaattgg     1380

tatcaacaaa aacccggcaa ggccccgaaa cgctggatct acgatacttc aaaggtggcc     1440

agcggtgtgc ctgcccgctt ctccgggtcg gggtccggca ccgattactc gttgactatc     1500

aatagcctgg aggccgagga cgctgcaact tactactgcc agcagtggtc ctccaaccct     1560

ctcaccttcg gaggcgggac caaggtggaa atcaaatag                            1599


<210>  77
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control (Anti-FHA) BiTE amino acid sequence with N-terminal 
       signal sequence without C-terminal deca-His tag

<400>  77

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Ser Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His 
            180                 185                 190         


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly 
        195                 200                 205             


Ile Ile Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro 
                245                 250                 255     


Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            260                 265                 270         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Thr Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
305                 310                 315                 320 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
        355                 360                 365             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
    450                 455                 460                 


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
465                 470                 475                 480 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                485                 490                 495     


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Val Glu Ile Lys 
    530         


<210>  78
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control BiTe (Anti-FHA) without C-terminal deca-His tag

<400>  78

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Asp Ile Val Met Thr Gln Ala Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Ser Ser Gly Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Ser Arg Ser Ser Leu Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Gly Tyr Thr Met His Trp Val Arg Gln Ser His 
            180                 185                 190         


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Lys Asn Gly Gly 
        195                 200                 205             


Ile Ile Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Asp 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Tyr Asp Asp Tyr Pro 
                245                 250                 255     


Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            260                 265                 270         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Thr Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
305                 310                 315                 320 


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
            340                 345                 350         


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
        355                 360                 365             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
    450                 455                 460                 


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
465                 470                 475                 480 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                485                 490                 495     


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Val Glu Ile Lys 
    530         


<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EpCam BiTE nucleic acid sequence (OKT3)

<400>  83
atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt gcatagcgaa       60

ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa ggtcaccatg      120

tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta cctcacgtgg      180

tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag cacccgcgag      240

tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac cctaaccatc      300

agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta ctcgtaccct      360

ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag cggcggggga      420

ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc cgaactggtc      480

cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt taccaattac      540

tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg cgacatcttc      600

ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac tctgactgcc      660

gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga agacagcgcg      720

gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg gggacaagga      780

actaccgtga ccgtctcctc cggcggcggt ggaagccagg tgcagctgca gcagtctggg      840

gctgaactgg caagacctgg ggcctcagtg aagatgtcct gcaaggcttc tggctacacc      900

tttactaggt acacgatgca ctgggtaaaa cagaggcctg gacagggtct ggaatggatt      960

ggatacatta atcctagccg tggttatact aattacaatc agaagttcaa ggacaaggcc     1020

acattgacta cagacaaatc ctccagcaca gcctacatgc aactgagcag cctgacatct     1080

gaggactctg cagtctatta ctgtgcaaga tattatgatg atcattactg ccttgactac     1140

tggggccaag gcaccactct cacagtctcc tcaggtggcg gtggctcggg cggtggtgga     1200

tctggtggcg gcggatctga tatcgtgctc actcagtctc cagcaatcat gtctgcatct     1260

ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgaactgg     1320

taccagcaga agtcaggcac ctcccccaaa agatggattt atgacacatc caaactggct     1380

tctggagtcc ctgctcactt caggggcagt gggtctggga cctcttactc tctcacaatc     1440

agcggcatgg aggctgaaga tgctgccact tattactgcc agcagtggag tagtaaccca     1500

ttcacgttcg gctcggggac aaagttggaa ataaaccgg                            1539


<210>  84

<400>  84
000

<210>  85
<211>  1551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAP BiTE nucleic acid sequence (OKT3)

<400>  85
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca ggtgcagctg      840

cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc ctgcaaggct      900

tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc tggacagggt      960

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa tcagaagttc     1020

aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat gcaactgagc     1080

agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga tgatcattac     1140

tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg cggtggctcg     1200

ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc tccagcaatc     1260

atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc aagtgtaagt     1320

tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca     1380

tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg gacctcttac     1440

tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg     1500

agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg g              1551


<210>  86

<400>  86
000

<210>  87
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAP BiTE nucleic acid sequence (aCD3)

<400>  87
atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt ccattcggac       60

atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg ggcgactatc      120

aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta cctggcctgg      180

tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc cacccgcgaa      240

agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac tctgaccatt      300

agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt ctcctatccg      360

ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag cgggggaggc      420

ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga agtcaagaag      480

ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac tgagtacacg      540

atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg gatcaaccca      600

aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat caccgtggat      660

acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga caccgcggtc      720

tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc gatggattac      780

tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaga tgtgcaactc      840

gtgcagtccg gtgcggaagt gaaaaagccg ggcgcgagcg tcaaagtgtc atgcaaggcg      900

tcaggatata cgtttactag atacactatg cactgggtgc gccaggcacc tggtcagggc      960

cttgaatgga tcggctacat caatccgtcg agaggctaca ctaattacgc ggactcagtc     1020

aaagggcgct tcacgattac gaccgacaag tccacctcga ctgcatacat ggaactgtcc     1080

tcgctgagaa gcgaggacac cgctacttac tactgcgcta gatactacga tgatcactac     1140

tgcctcgatt actggggcca gggaaccact gtcacggtgt catcgggaga gggcacctca     1200

accggatcag ggggatcggg aggctcgggc ggcgcagacg acatcgtcct gacccagtcg     1260

cccgccacct tgtcgctgtc cccaggagaa agagcgaccc tgtcatgccg ggcgtcgcaa     1320

agcgtgagct atatgaattg gtatcagcag aagccaggaa aggcgccgaa gagatggatc     1380

tacgacacct ccaaggtcgc ttcaggtgtc ccggctagat tctcaggatc gggatcagga     1440

acggactact ccctgaccat caattcactg gaagcagaag atgcggccac ctactactgt     1500

cagcagtggt cctccaaccc gctgactttc ggaggcggaa ctaaggtcga gatcaag        1557


<210>  88
<211>  1856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-611 Transgene cassette

<400>  88
caggcccacc atgggatgga gctgcatcat cctattcctc gtggcgacgg ccactggagt       60

gcatagcgaa ctggtgatga ctcagtcccc gtcatccctg acggtgaccg ccggcgagaa      120

ggtcaccatg tcgtgcaagt cctcgcaaag cctgcttaac agcggcaacc agaaaaacta      180

cctcacgtgg tatcagcaaa agccaggtca acccccaaaa ctgctcatct actgggcgag      240

cacccgcgag tcgggggtgc cagaccggtt caccggctcc gggtcaggaa ctgatttcac      300

cctaaccatc agctcggtgc aagcggagga cctggccgtg tactactgcc aaaatgatta      360

ctcgtaccct ctgacctttg gagcgggcac caagctcgaa atcaagggcg gtggaggaag      420

cggcggggga ggctcaggtg ggggaggatc agaagtccaa ctgctggagc agtcaggagc      480

cgaactggtc cgcccgggaa cctccgtcaa gatttcctgt aaggcttccg gctacgcttt      540

taccaattac tggctgggct gggtcaagca aagaccgggg catggcctgg agtggatcgg      600

cgacatcttc ccagggagcg gcaacatcca ctacaacgag aagttcaagg ggaaagcgac      660

tctgactgcc gacaaatcat ccagcaccgc ctacatgcag ctgtcgtcgc tcactttcga      720

agacagcgcg gtgtactttt gtgctcggct ccggaactgg gatgaaccaa tggactactg      780

gggacaagga actaccgtga ccgtctcctc cggcggcggt ggaagccagg tgcagctgca      840

gcagtctggg gctgaactgg caagacctgg ggcctcagtg aagatgtcct gcaaggcttc      900

tggctacacc tttactaggt acacgatgca ctgggtaaaa cagaggcctg gacagggtct      960

ggaatggatt ggatacatta atcctagccg tggttatact aattacaatc agaagttcaa     1020

ggacaaggcc acattgacta cagacaaatc ctccagcaca gcctacatgc aactgagcag     1080

cctgacatct gaggactctg cagtctatta ctgtgcaaga tattatgatg atcattactg     1140

ccttgactac tggggccaag gcaccactct cacagtctcc tcaggtggcg gtggctcggg     1200

cggtggtgga tctggtggcg gcggatctga tatcgtgctc actcagtctc cagcaatcat     1260

gtctgcatct ccaggggaga aggtcaccat gacctgcagt gccagctcaa gtgtaagtta     1320

catgaactgg taccagcaga agtcaggcac ctcccccaaa agatggattt atgacacatc     1380

caaactggct tctggagtcc ctgctcactt caggggcagt gggtctggga cctcttactc     1440

tctcacaatc agcggcatgg aggctgaaga tgctgccact tattactgcc agcagtggag     1500

tagtaaccca ttcacgttcg gctcggggac aaagttggaa ataaaccggc atcaccatca     1560

ccatcaccac catcaccatt aggctagctt gactgactga gatacagcgt accttcagct     1620

cacagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa     1680

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg     1740

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt     1800

gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtagtcgtc agctat         1856


<210>  89
<211>  1868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-612 Transgene cassette

<400>  89
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gcatcaccat caccatcacc accatcacca ttaggctagc ttgactgact gagatacagc     1620

gtaccttcag ctcacagaca tgataagata cattgatgag tttggacaaa ccacaactag     1680

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     1740

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     1800

tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtagtcg     1860

tcagctat                                                              1868


<210>  90
<211>  1878
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-613 Transgene cassette

<400>  90
tttctctctt caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg       60

ctaccggagt ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac      120

tgggagagcg ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc      180

agaaaaacta cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct      240

tctgggcctc cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa      300

ctgactttac tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc      360

agcagtattt ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag      420

ggggcggcag cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat      480

ccggagccga agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct      540

acaccttcac tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt      600

ggatcggcgg gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc      660

gggtgactat caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca      720

gatcggagga caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg      780

aaggacatgc gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg      840

gcggttcaca ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag      900

tgaagatgtc ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa      960

aacagaggcc tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata     1020

ctaattacaa tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca     1080

cagcctacat gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa     1140

gatattatga tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct     1200

cctcaggtgg cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc     1260

tcactcagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca     1320

gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca     1380

aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca     1440

gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca     1500

cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg     1560

aaataaaccg gcatcaccat caccatcacc accatcacca ttaggctagc ttgactgact     1620

gagatacagc gtaccttcag ctcacagaca tgataagata cattgatgag tttggacaaa     1680

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     1740

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     1800

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     1860

gtggtagtcg tcagctat                                                   1878


<210>  91
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-614 Transgene cassette

<400>  91
tttctctctt caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg       60

ctaccggagt ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac      120

tgggagagcg ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc      180

agaaaaacta cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct      240

tctgggcctc cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa      300

ctgactttac tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc      360

agcagtattt ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag      420

ggggcggcag cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat      480

ccggagccga agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct      540

acaccttcac tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt      600

ggatcggcgg gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc      660

gggtgactat caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca      720

gatcggagga caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg      780

aaggacatgc gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg      840

gcggttcaga tgtgcaactc gtgcagtccg gtgcggaagt gaaaaagccg ggcgcgagcg      900

tcaaagtgtc atgcaaggcg tcaggatata cgtttactag atacactatg cactgggtgc      960

gccaggcacc tggtcagggc cttgaatgga tcggctacat caatccgtcg agaggctaca     1020

ctaattacgc ggactcagtc aaagggcgct tcacgattac gaccgacaag tccacctcga     1080

ctgcatacat ggaactgtcc tcgctgagaa gcgaggacac cgctacttac tactgcgcta     1140

gatactacga tgatcactac tgcctcgatt actggggcca gggaaccact gtcacggtgt     1200

catcgggaga gggcacctca accggatcag ggggatcggg aggctcgggc ggcgcagacg     1260

acatcgtcct gacccagtcg cccgccacct tgtcgctgtc cccaggagaa agagcgaccc     1320

tgtcatgccg ggcgtcgcaa agcgtgagct atatgaattg gtatcagcag aagccaggaa     1380

aggcgccgaa gagatggatc tacgacacct ccaaggtcgc ttcaggtgtc ccggctagat     1440

tctcaggatc gggatcagga acggactact ccctgaccat caattcactg gaagcagaag     1500

atgcggccac ctactactgt cagcagtggt cctccaaccc gctgactttc ggaggcggaa     1560

ctaaggtcga gatcaagcat caccatcacc atcaccacca tcaccattag gctagcttga     1620

ctgactgaga tacagcgtac cttcagctca cagacatgat aagatacatt gatgagtttg     1680

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     1740

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     1800

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct     1860

acaaatgtgg tagtcgtcag ctat                                            1884


<210>  92
<211>  1838
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-617 Transgene cassette

<400>  92
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gtaggctagc ttgactgact gagatacagc gtaccttcag ctcacagaca tgataagata     1620

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     1680

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     1740

caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag     1800

caagtaaaac ctctacaaat gtggtagtcg tcagctat                             1838


<210>  93
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCam BiTE amino acid sequence (OKT3)

<400>  93

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
145                 150                 155                 160 


Arg Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
                165                 170                 175     


Phe Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr 
        195                 200                 205             


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
    290                 295                 300                 


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
                325                 330                 335     


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ile 
                405                 410                 415     


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
        435                 440                 445             


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            500                 505                 510         


Arg 
    


<210>  94
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP BiTE amino acid sequence (OKT3)

<400>  94

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe 
                165                 170                 175     


Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
        275                 280                 285             


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
    290                 295                 300                 


Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly 
305                 310                 315                 320 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                325                 330                 335     


Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser 
            340                 345                 350         


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
        355                 360                 365             


Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
                405                 410                 415     


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
            420                 425                 430         


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
        435                 440                 445             


Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
    450                 455                 460                 


Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr 
465                 470                 475                 480 


Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys 
            500                 505                 510         


Leu Glu Ile Asn Arg 
        515         


<210>  95
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP BiTE amino acid sequence (aCD3)

<400>  95

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe 
                165                 170                 175     


Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
            180                 185                 190         


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        275                 280                 285             


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    290                 295                 300                 


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
305                 310                 315                 320 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr 
            340                 345                 350         


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
    370                 375                 380                 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser 
385                 390                 395                 400 


Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
                405                 410                 415     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            420                 425                 430         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    450                 455                 460                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys 
        515                 


<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flt3L nucleic acid sequence

<400>  105
atgacagtgc tggcgccagc ctggagccca acaacctatc tcctcctgct gctgctgctg       60

agctcgggac tcagtgggac ccaggactgc tccttccaac acagccccat ctcctccgac      120

ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg      180

gcctccaacc tccaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag      240

cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc      300

gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt      360

cgcttcgtcc agaccaacat ctcccgcctc ctacaggaga cctccgagca gctggtggcg      420

ctgaagccct ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc      480

gactcctcaa ccctgccacc cccatggagt ccccggcccc tggaggccac agccccg         537


<210>  106

<400>  106
000

<210>  107
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MIP1 alpha nucleic acid sequence

<400>  107
atgcaggtct ccactgctgc ccttgccgtc ctcctctgca ccatggctct ctgcaaccag       60

gtcctctctg caccacttgc tgctgacacg ccgaccgcct gctgcttcag ctacacctcc      120

cgacagattc cacagaattt catagctgac tactttgaga cgagcagcca gtgctccaag      180

cccagtgtca tcttcctaac caagagaggc cggcaggtct gtgctgaccc cagtgaggag      240

tgggtccaga aatacgtcag tgacctggag ctgagtgcc                             279


<210>  108
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  108

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  109
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFN alpha nucleic acid sequence

<400>  109
atggccttga cctttgcttt actggtggcc ctcctggtgc tcagctgcaa gtcaagctgc       60

tctgtgggct gtgatctgcc tcaaacccac agcctgggta gcaggaggac cttgatgctc      120

ctggcacaga tgaggagaat ctctcttttc tcctgcttga aggacagaca tgactttgga      180

tttccccagg aggagtttgg caaccagttc caaaaggctg aaaccatccc tgtcctccat      240

gagatgatcc agcagatctt caatctcttc agcacaaagg actcatctgc tgcttgggat      300

gagaccctcc tagacaaatt ctacactgaa ctctaccagc agctgaatga cctggaagcc      360

tgtgtgatac agggggtggg ggtgacagag actcccctga tgaaggagga ctccattctg      420

gctgtgagga aatacttcca aagaatcact ctctatctga aagagaagaa atacagccct      480

tgtgcctggg aggttgtcag agcagaaatc atgagatctt tttctttgtc aacaaacttg      540

caagaaagtt taagaagtaa ggaa                                             564


<210>  110
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL10 nucleic acid sequence

<400>  110
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcct            294


<210>  111
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL9 nucleic acid sequence

<400>  111
aagaaaagtg gtgttctttt cctcttgggc atcatcttgc tggttctgat tggagtgcaa       60

ggaaccccag tagtgagaaa gggtcgctgt tcctgcatca gcaccaacca agggactatc      120

cacctacaat ccttgaaaga ccttaaacaa tttgccccaa gcccttcctg cgagaaaatt      180

gaaatcattg ctacactgaa gaatggagtt caaacatgtc taaacccaga ttcagcagat      240

gtgaaggaac tgattaaaaa gtgggagaaa caggtcagcc aaaagaaaaa gcaaaagaat      300

gggaaaaaac atcaaaaaaa gaaagttctg aaagttcgaa aatctcaacg ttctcgtcaa      360

aagaagacta ca                                                          372


<210>  112
<211>  3407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-615 Transgene cassette

<400>  112
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gggaagcgga cagtgtacta attatgctct cttgaaattg gctggagatg ttgagagcaa     1620

ccctggacct acagtgctgg cgccagcctg gagcccaaca acctatctcc tcctgctgct     1680

gctgctgagc tcgggactca gtgggaccca ggactgctcc ttccaacaca gccccatctc     1740

ctccgacttc gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt     1800

caccgtggcc tccaacctcc aggacgagga gctctgcggg ggcctctggc ggctggtcct     1860

ggcacagcgc tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct     1920

ggagcgcgtg aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag     1980

ctgtcttcgc ttcgtccaga ccaacatctc ccgcctccta caggagacct ccgagcagct     2040

ggtggcgctg aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg     2100

tcagcccgac tcctcaaccc tgccaccccc atggagtccc cggcccctgg aggccacagc     2160

cccgggaagc ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa     2220

ccctggacct caggtctcca ctgctgccct tgccgtcctc ctctgcacca tggctctctg     2280

caaccaggtc ctctctgcac cacttgctgc tgacacgccg accgcctgct gcttcagcta     2340

cacctcccga cagattccac agaatttcat agctgactac tttgagacga gcagccagtg     2400

ctccaagccc agtgtcatct tcctaaccaa gagaggccgg caggtctgtg ctgaccccag     2460

tgaggagtgg gtccagaaat acgtcagtga cctggagctg agtgccggaa gcggagaggg     2520

cagaggaagt ctgctaacat gcggtgacgt cgaggagaat cctggacctg ccttgacctt     2580

tgctttactg gtggccctcc tggtgctcag ctgcaagtca agctgctctg tgggctgtga     2640

tctgcctcaa acccacagcc tgggtagcag gaggaccttg atgctcctgg cacagatgag     2700

gagaatctct cttttctcct gcttgaagga cagacatgac tttggatttc cccaggagga     2760

gtttggcaac cagttccaaa aggctgaaac catccctgtc ctccatgaga tgatccagca     2820

gatcttcaat ctcttcagca caaaggactc atctgctgct tgggatgaga ccctcctaga     2880

caaattctac actgaactct accagcagct gaatgacctg gaagcctgtg tgatacaggg     2940

ggtgggggtg acagagactc ccctgatgaa ggaggactcc attctggctg tgaggaaata     3000

cttccaaaga atcactctct atctgaaaga gaagaaatac agcccttgtg cctgggaggt     3060

tgtcagagca gaaatcatga gatctttttc tttgtcaaca aacttgcaag aaagtttaag     3120

aagtaaggaa taagctagct tgactgactg agatacagcg taccttcagc tcacagacat     3180

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     3240

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     3300

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     3360

tttttaaagc aagtaaaacc tctacaaatg tggtagtcgt cagctat                   3407


<210>  113
<211>  2630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-640 Transgene cassette

<400>  113
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gggaagcgga gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc     1620

tggacctaat caaactgcca ttctgatttg ctgccttatc tttctgactc taagtggcat     1680

tcaaggagta cctctctcta gaactgtacg ctgtacctgc atcagcatta gtaatcaacc     1740

tgttaatcca aggtctttag aaaaacttga aattattcct gcaagccaat tttgtccacg     1800

tgttgagatc attgctacaa tgaaaaagaa gggtgagaag agatgtctga atccagaatc     1860

gaaggccatc aagaatttac tgaaagcagt tagcaaggaa aggtctaaaa gatctcctgg     1920

aagcggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggacc     1980

taagaaaagt ggtgttcttt tcctcttggg catcatcttg ctggttctga ttggagtgca     2040

aggaacccca gtagtgagaa agggtcgctg ttcctgcatc agcaccaacc aagggactat     2100

ccacctacaa tccttgaaag accttaaaca atttgcccca agcccttcct gcgagaaaat     2160

tgaaatcatt gctacactga agaatggagt tcaaacatgt ctaaacccag attcagcaga     2220

tgtgaaggaa ctgattaaaa agtgggagaa acaggtcagc caaaagaaaa agcaaaagaa     2280

tgggaaaaaa catcaaaaaa agaaagttct gaaagttcga aaatctcaac gttctcgtca     2340

aaagaagact acataagcta gcttgactga ctgagataca gcgtaccttc agctcacaga     2400

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     2460

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     2520

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     2580

ggttttttaa agcaagtaaa acctctacaa atgtggtagt cgtcagctat                2630


<210>  114
<211>  3260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-641 Transgene cassette

<400>  114
caggcccacc atgggctgga gctgcatcat cttgttcctg gtcgcaactg ctaccggagt       60

ccattcggac atcgtcatga cccaaagccc tgactcgctc gctgtgtcac tgggagagcg      120

ggcgactatc aactgcaaat catcccagag cctgctgtat tcacgcaatc agaaaaacta      180

cctggcctgg tatcagcaga agccgggcca gcctcccaag ctgctgatct tctgggcctc      240

cacccgcgaa agcggcgtgc cggaccgctt cagcggaagc ggattcggaa ctgactttac      300

tctgaccatt agctccttgc aggcggagga cgtggccgtc tactactgcc agcagtattt      360

ctcctatccg ctcacctttg ggcaaggcac caaggtggag attaagggag ggggcggcag      420

cgggggaggc ggcagcggcg gcgggggatc gcaggtccag ctcgtccaat ccggagccga      480

agtcaagaag ccgggagcgt cggtcaaggt cagctgcaaa acttcgcgct acaccttcac      540

tgagtacacg atccactggg tccgccaggc gcccggccag cggctggagt ggatcggcgg      600

gatcaaccca aacaacggaa tcccaaatta caatcagaaa tttaaagggc gggtgactat      660

caccgtggat acctcggcct ccacggcgta catggagctc tcatcactca gatcggagga      720

caccgcggtc tattactgcg cccgccgccg gatcgcttat ggatacgatg aaggacatgc      780

gatggattac tggggccagg gcaccctcgt cacggtgtcg tcaggaggcg gcggttcaca      840

ggtgcagctg cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc      900

ctgcaaggct tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc      960

tggacagggt ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa     1020

tcagaagttc aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat     1080

gcaactgagc agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga     1140

tgatcattac tgccttgact actggggcca aggcaccact ctcacagtct cctcaggtgg     1200

cggtggctcg ggcggtggtg gatctggtgg cggcggatct gatatcgtgc tcactcagtc     1260

tccagcaatc atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc     1320

aagtgtaagt tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat     1380

ttatgacaca tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg     1440

gacctcttac tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg     1500

ccagcagtgg agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg     1560

gggaagcgga gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc     1620

tggacctaat caaactgcca ttctgatttg ctgccttatc tttctgactc taagtggcat     1680

tcaaggagta cctctctcta gaactgtacg ctgtacctgc atcagcatta gtaatcaacc     1740

tgttaatcca aggtctttag aaaaacttga aattattcct gcaagccaat tttgtccacg     1800

tgttgagatc attgctacaa tgaaaaagaa gggtgagaag agatgtctga atccagaatc     1860

gaaggccatc aagaatttac tgaaagcagt tagcaaggaa aggtctaaaa gatctcctgg     1920

aagcggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggacc     1980

taagaaaagt ggtgttcttt tcctcttggg catcatcttg ctggttctga ttggagtgca     2040

aggaacccca gtagtgagaa agggtcgctg ttcctgcatc agcaccaacc aagggactat     2100

ccacctacaa tccttgaaag accttaaaca atttgcccca agcccttcct gcgagaaaat     2160

tgaaatcatt gctacactga agaatggagt tcaaacatgt ctaaacccag attcagcaga     2220

tgtgaaggaa ctgattaaaa agtgggagaa acaggtcagc caaaagaaaa agcaaaagaa     2280

tgggaaaaaa catcaaaaaa agaaagttct gaaagttcga aaatctcaac gttctcgtca     2340

aaagaagact acaggaagcg gacagtgtac taattatgct ctcttgaaat tggctggaga     2400

tgttgagagc aaccctggac ctgccttgac ctttgcttta ctggtggccc tcctggtgct     2460

cagctgcaag tcaagctgct ctgtgggctg tgatctgcct caaacccaca gcctgggtag     2520

caggaggacc ttgatgctcc tggcacagat gaggagaatc tctcttttct cctgcttgaa     2580

ggacagacat gactttggat ttccccagga ggagtttggc aaccagttcc aaaaggctga     2640

aaccatccct gtcctccatg agatgatcca gcagatcttc aatctcttca gcacaaagga     2700

ctcatctgct gcttgggatg agaccctcct agacaaattc tacactgaac tctaccagca     2760

gctgaatgac ctggaagcct gtgtgataca gggggtgggg gtgacagaga ctcccctgat     2820

gaaggaggac tccattctgg ctgtgaggaa atacttccaa agaatcactc tctatctgaa     2880

agagaagaaa tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcttt     2940

ttctttgtca acaaacttgc aagaaagttt aagaagtaag gaataagcta gcttgactga     3000

ctgagataca gcgtaccttc agctcacaga catgataaga tacattgatg agtttggaca     3060

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     3120

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     3180

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa     3240

atgtggtagt cgtcagctat                                                 3260


<210>  115
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3L amino acid sequence

<400>  115

Met Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 
1               5                   10                  15      


Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 
            20                  25                  30          


Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 
        35                  40                  45              


Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 
    50                  55                  60                  


Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 
65                  70                  75                  80  


His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 
                85                  90                  95      


Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 
            100                 105                 110         


Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 
        115                 120                 125             


Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp 
    130                 135                 140                 


Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro 
145                 150                 


<210>  116
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIP1 alpha amino acid sequence

<400>  116

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  117
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFN alpha amino acid sequence

<400>  117

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  118
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL9 amino acid sequence

<400>  118

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  119
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL10 amino acid sequence

<400>  119

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  120
<211>  35788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-618 Genome

<400>  120
tctatctata taatatacct tatagatgga atggtgccaa tatgtaaatg aggtgatttt       60

aaaaagtgtg gatcgtgtgg tgattggctg tggggttaac ggctaaaagg ggcggtgcga      120

ccgtgggaaa atgacgtttt gtgggggtgg agtttttttg caagttgtcg cgggaaatgt      180

gacgcataaa aaggcttttt tctcacggaa ctacttagtt ttcccacggt atttaacagg      240

aaatgaggta gttttgaccg gatgcaagtg aaaattgttg attttcgcgc gaaaactgaa      300

tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg      360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt      420

ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctagggtatt      480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc      540

tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat      600

aatctctgct gagactggaa atgaaatatt ggagcttgtg gtgcacgccc tgatgggaga      660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt      720

agaggtagag ggatcggagg attctaatga ggaagctgta aatggctttt ttaccgattc      780

tatgctttta gctgctaatg aagggttaga attagatccg cctttggaca cttttgatac      840

tccaggggta attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgagttccgt      900

ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga      960

aaaggagcag tccatgcaga ctgcagcggg tgagggagtg aaggctgcca atgttggttt     1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa     1080

aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagaacgc actgccactt     1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat     1200

attgagtgtg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgaatcacc     1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg     1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga     1380

cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacgtc caagacaata     1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaca gtgcaatgta     1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata     1560

taagtagaag cagacctgtg tggttagctc ataggagctg gctttcatcc atggaggttt     1620

gggccatttt ggaagacctt aggaagacta ggcaactgtt agagaacgct tcggacggag     1680

tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa     1740

aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag     1800

ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt ttagactttt     1860

caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta gataaatgga     1920

tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca gcattgtgga     1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg     2040

gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc     2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt     2160

gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt     2220

taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat     2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtt cagaaagagg gaagggatga     2340

agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc     2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa     2460

acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg     2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat     2580

gtggcctggg gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga     2640

tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt     2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag     2760

tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa     2820

atgcatattt caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca     2880

ctgcgcttct acagatactg gatgttttat tttgattaag ggaaatgcca gcgtaaagca     2940

taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgctggtgg     3000

gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt     3060

ttttgatcac aatgtgatga cgaagtgtac catgcatgca ggtgggcgta gaggaatgtt     3120

tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc     3180

cagaatgagc ctaacaggaa tttttgacat gaacatgcaa atctggaaga tcctgaggta     3240

tgatgatacg agatcgaggg tacgcgcatg cgaatgcgga ggcaagcatg ccaggttcca     3300

gccggtgtgt gtagatgtga ctgaagatct cagaccggat catttggtta ttgcccgcac     3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt     3420

tggggtggga ttttcagatg gacagattga gtaaaaattt gttttttctg tcttgcagct     3480

gtcatgagtg gaaacgcttc ttttaagggg ggagtcttca gcccttatct gacagggcgt     3540

ctcccatcct gggcaggagt tcgtcagaat gttatgggat ctactgtgga tggaagaccc     3600

gtccaacccg ccaattcttc aacgctgacc tatgctactt taagttcttc acctttggac     3660

gcagctgcag ctgccgccgc cgcttctgtt gccgctaaca ctgtgcttgg aatgggttac     3720

tatggaagca tcatggctaa ttccacttcc tctaataacc cttctaccct gactcaggac     3780

aagttacttg tccttttggc ccagctggag gctttgaccc aacgtctggg tgaactttct     3840

cagcaggtgg tcgagttgcg agtacaaact gagtctgctg tcggcacggc aaagtctaaa     3900

taaaaaaatc ccagaatcaa tgaataaata aacaagcttg ttgttgattt aaaatcaagt     3960

gtttttattt catttttcgc gcacggtatg ccctagacca ccgatctcta tcattgagaa     4020

ctcggtggat tttttccagg atcctataga ggtgggattg aatgtttaga tacatgggca     4080

ttaggccgtc tttggggtgg agatagctcc attgaaggga ttcatgctcc ggggtagtgt     4140

tgtaaatcac ccagtcataa caaggtcgca gtgcatggtg ttgcacaata tcttttagaa     4200

gtaggctgat tgccacagat aagcccttgg tgtaggtgtt tacaaaccgg ttgagctggg     4260

atgggtgcat tcggggtgaa attatgtgca ttttggattg gatttttaag ttggcaatat     4320

tgccgccaag atcccgtctt gggttcatgt tatgaaggac caccaagacg gtgtatccgg     4380

tacatttagg aaatttatcg tgcagcttgg atggaaaagc gtggaaaaat ttggagacac     4440

ccttgtgtcc tccaagattt tccatgcact catccatgat aatagcaatg gggccgtggg     4500

cagcggcgcg ggcaaacacg ttccgtgggt ctgacacatc atagttatgt tcctgagtta     4560

aatcatcata agccatttta atgaatttgg ggcggagagt accagattgg ggtatgaatg     4620

ttccttcggg ccccggagca tagttcccct cacagatttg catttcccaa gctttcagtt     4680

ccgagggtgg aatcatgtcc acctgggggg ctatgaaaaa caccgtttct ggggcggggg     4740

tgattaattg tgatgatagc aaatttctga gcaattgaga tttgccacat ccggtggggc     4800

cataaatgat tccgattacg ggttgcaggt ggtagtttag ggaacggcaa ctgccgtctt     4860

ctcgaagcaa gggggccacc tcgttcatca tttcccttac atgcatattt tcccgcacca     4920

aatccattag gaggcgctct cctcctagtg atagaagttc ttgtagtgag gaaaagtttt     4980

tcagcggttt cagaccgtca gccatgggca ttttggagag agtttgctgc aaaagttcta     5040

gtctgttcca cagttcagtg atgtgttcta tggcatctcg atccagcaga cctcctcgtt     5100

tcgcgggttt ggacggctcc tggaataggg tatgagacga tgggcgtcca gcgctgccag     5160

ggttcggtcc ttccagggtc tcagtgttcg agtcagggtt gtttccgtca cagtgaaggg     5220

gtgtgcgcct gcttgggcgc ttgccagggt gcgcttcaga ctcatcctgc tggtcgaaaa     5280

cttctgtcgc ttggcgccct gtatgtcggc caagtagcag tttaccatga gttcgtagtt     5340

gagcgcctcg gctgcgtggc ctttggcgcg gagcttacct ttggaagttt tcttgcatac     5400

cgggcagtat aggcatttca gcgcatacaa cttgggcgca aggaaaacgg attctgggga     5460

gtatgcatct gcgccgcagg aggcgcaaac agtttcacat tccaccagcc aggttaaatc     5520

cggttcattg gggtcaaaaa caagttttcc gccatatttt ttgatgcgtt tcttaccttt     5580

ggtctccatg agttcgtgtc ctcgttgagt gacaaacagg ctgtccgtgt ccccgtagac     5640

tgattttaca ggcctcttct ccagtggagt gcctcggtct tcttcgtaca ggaactctga     5700

ccactctgat acaaaggcgc gcgtccaggc cagcacaaag gaggctatgt gggaggggta     5760

gcgatcgttg tcaaccaggg ggtccacctt ttccaaagta tgcaaacaca tgtcaccctc     5820

ttcaacatcc aggaatgtga ttggcttgta ggtgtatttc acgtgacctg gggtccccgc     5880

tgggggggta taaaaggggg cggttctttg ctcttcctca ctgtcttccg gatcgctgtc     5940

caggaacgtc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctctgcact     6000

caggttgtca gtttctaaga acgaggagga tttgatattg acagtgccgg ttgagatgcc     6060

tttcatgagg ttttcgtcca tctggtcaga aaacacaatt tttttattgt caagtttggt     6120

ggcaaatgat ccatacaggg cgttggataa aagtttggca atggatcgca tggtttggtt     6180

cttttccttg tccgcgcgct ctttggcggc gatgttgagt tggacatact cgcgtgccag     6240

gcacttccat tcggggaaga tagttgttaa ttcatctggc acgattctca cttgccaccc     6300

tcgattatgc aaggtaatta aatccacact ggtggccacc tcgcctcgaa ggggttcatt     6360

ggtccaacag agcctacctc ctttcctaga acagaaaggg ggaagtgggt ctagcataag     6420

ttcatcggga gggtctgcat ccatggtaaa gattcccgga agtaaatcct tatcaaaata     6480

gctgatggga gtggggtcat ctaaggccat ttgccattct cgagctgcca gtgcgcgctc     6540

atatgggtta aggggactgc cccatggcat gggatgggtg agtgcagagg catacatgcc     6600

acagatgtca tagacgtaga tgggatcctc aaagatgcct atgtaggttg gatagcatcg     6660

cccccctctg atacttgctc gcacatagtc atatagttca tgtgatggcg ctagcagccc     6720

cggacccaag ttggtgcgat tgggtttttc tgttctgtag acgatctggc gaaagatggc     6780

gtgagaattg gaagagatgg tgggtctttg aaaaatgttg aaatgggcat gaggtagacc     6840

tacagagtct ctgacaaagt gggcataaga ttcttgaagc ttggttacca gttcggcggt     6900

gacaagtacg tctagggcgc agtagtcaag tgtttcttga atgatgtcat aacctggttg     6960

gtttttcttt tcccacagtt cgcggttgag aaggtattct tcgcgatcct tccagtactc     7020

ttctagcgga aacccgtctt tgtctgcacg gtaagatcct agcatgtaga actgattaac     7080

tgccttgtaa gggcagcagc ccttctctac gggtagagag tatgcttgag cagcttttcg     7140

tagcgaagcg tgagtaaggg caaaggtgtc tctgaccatg actttgagga attggtattt     7200

gaagtcgatg tcgtcacagg ctccctgttc ccagagttgg aagtctaccc gtttcttgta     7260

ggcggggttg ggcaaagcga aagtaacatc attgaagaga atcttgccgg ccctgggcat     7320

gaaattgcga gtgatgcgaa aaggctgtgg tacttccgct cggttattga taacctgggc     7380

agctaggacg atctcgtcga aaccgttgat gttgtgtcct acgatgtata attctatgaa     7440

acgcggcgtg cctctgacgt gaggtagctt actgagctca tcaaaggtta ggtctgtggg     7500

gtcagataag gcgtagtgtt cgagagccca ttcgtgcagg tgaggattcg ctttaaggaa     7560

ggaggaccag aggtccactg ccagtgctgt ttgtaactgg tcccggtact gacgaaaatg     7620

ccgtccgact gccatttttt ctggggtgac gcaatagaag gtttgggggt cctgccgcca     7680

gcgatcccac ttgagtttta tggcgaggtc ataggcgatg ttgacgagcc gctggtctcc     7740

agagagtttc atgaccagca tgaaggggat tagctgcttg ccaaaggacc ccatccaggt     7800

gtaggtttcc acatcgtagg tgagaaagag cctttctgtg cgaggatgag agccaatcgg     7860

gaagaactgg atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa     7920

ctccctgcga cgcgccgagc attcatgctt gtgcttgtac agacggccgc agtagtcgca     7980

gcgttgcacg ggttgtatct cgtgaatgag ttgtacctgg cttcccttga cgagaaattt     8040

cagtgggaag ccgaggcctg gcgattgtat ctcgtgcttt actatgttgt ctgcatcggc     8100

ctgttcatct tctgtctcga tggtggtcat gctgacgagc cctcgcggga ggcaagtcca     8160

gacctcggcg cggcaggggc ggagctcgag gacgagagcg cgcaggctgg agctgtccag     8220

ggtcctgaga cgctgcggac tcaggttagt aggcagtgtc aggagattaa cttgcatgat     8280

cttttggagg gcgtgcggga ggttcagata gtacttgatc tcaacgggtc cgttggtgga     8340

gatgtcgatg gcttgcaggg ttccgtgtcc cttgggcgct accaccgtgc ccttgttttt     8400

cattttggac ggcggtggct ctgttgcttc ttgcatgttt agaagcggtg tcgagggcgc     8460

gcaccgggcg gcaggggcgg ctcgggaccc ggcggcatgg ctggcagtgg tacgtcggcg     8520

ccgcgcgcgg gtaggttctg gtactgcgcc ctgagaagac tcgcatgcgc gacgacgcgg     8580

cggttgacat cctggatctg acgcctctgg gtgaaagcta ccggccccgt gagcttgaac     8640

ctgaaagaga gttcaacaga atcaatctcg gtatcgttga cggcggcttg cctaaggatt     8700

tcttgcacgt caccagagtt gtcctggtag gcgatctccg ccatgaactg ctcgatctct     8760

tcctcttgaa gatctccgcg gcccgctctc tcgacggtgg ccgcgaggtc gttggagatg     8820

cgcccaatga gttgagagaa tgcattcatg cccgcctcgt tccagacgcg gctgtagacc     8880

acggccccca cgggatctct cgcgcgcatg accacctggg cgaggttgag ctccacgtgg     8940

cgggtgaaga ccgcatagtt gcataggcgc tggaaaaggt agttgagtgt ggtggcgatg     9000

tgctcggtga cgaagaaata catgatccat cgtctcagcg gcatctcgct gacatcgccc     9060

agagcttcca agcgctccat ggcctcgtag aagtccacgg caaaattaaa aaactgggag     9120

tttcgcgcgg acacggtcaa ctcctcttcc agaagacgga taagttcggc gatggtggtg     9180

cgcacctcgc gctcgaaagc ccctgggatt tcttcctcaa tctcttcttc ttccactaac     9240

atctcttcct cttcaggtgg ggctgcagga ggagggggaa cgcggcgacg ccggcggcgc     9300

acgggcagac ggtcgatgaa tctttcaatg acctctccgc ggcggcggcg catggtttca     9360

gtgacggcgc ggccgttctc gcgcggtcgc agagtaaaaa caccgccgcg catctcctta     9420

aagtggtgac tgggaggttc tccgtttggg agggagaggg cgctgattat acattttatt     9480

aattggcccg tagggactgc acgcagagat ctgatcgtgt caagatccac gggatctgaa     9540

aacctttcga cgaaagcgtc taaccagtca cagtcacaag gtaggctgag tacggcttct     9600

tgtgggcggg ggtggttatg tgttcggtct gggtcttctg tttcttcttc atctcgggaa     9660

ggtgagacga tgctgctggt gatgaaatta aagtaggcag ttctaagacg gcggatggtg     9720

gcgaggagca ccaggtcttt gggtccggct tgctggatac gcaggcgatt ggccattccc     9780

caagcattat cctgacatct agcaagatct ttgtagtagt cttgcatgag ccgttctacg     9840

ggcacttctt cctcacccgt tctgccatgc atacgtgtga gtccaaatcc gcgcattggt     9900

tgtaccagtg ccaagtcagc tacgactctt tcggcgagga tggcttgctg tacttgggta     9960

agggtggctt gaaagtcatc aaaatccaca aagcggtggt aagctcctgt attaatggtg    10020

taagcacagt tggccatgac tgaccagtta actgtctggt gaccagggcg cacgagctcg    10080

gtgtatttaa ggcgcgaata ggcgcgggtg tcaaagatgt aatcgttgca ggtgcgcacc    10140

agatactggt accctataag aaaatgcggc ggtggttggc ggtagagagg ccatcgttct    10200

gtagctggag cgccaggggc gaggtcttcc aacataaggc ggtgatagcc gtagatgtac    10260

ctggacatcc aggtgattcc tgcggcggta gtagaagccc gaggaaactc gcgtacgcgg    10320

ttccaaatgt tgcgtagcgg catgaagtag ttcattgtag gcacggtttg accagtgagg    10380

cgcgcgcagt cattgatgct ctatagacac ggagaaaatg aaagcgttca gcgactcgac    10440

tccgtagcct ggaggaacgt gaacgggttg ggtcgcggtg taccccggtt cgagacttgt    10500

actcgagccg gccggagccg cggctaacgt ggtattggca ctcccgtctc gacccagcct    10560

acaaaaatcc aggatacgga atcgagtcgt tttgctggtt tccgaatggc agggaagtga    10620

gtcctatttt ttttttttgc cgctcagatg catcccgtgc tgcgacagat gcgcccccaa    10680

caacagcccc cctcgcagca gcagcagcag caatcacaaa aggctgtccc tgcaactact    10740

gcaactgccg ccgtgagcgg tgcgggacag cccgcctatg atctggactt ggaagagggc    10800

gaaggactgg cacgtctagg tgcgccttca cccgagcggc atccgcgagt tcaactgaaa    10860

aaagattctc gcgaggcgta tgtgccccaa cagaacctat ttagagacag aagcggcgag    10920

gagccggagg agatgcgagc ttcccgcttt aacgcgggtc gtgagctgcg tcacggtttg    10980

gaccgaagac gagtgttgcg ggacgaggat ttcgaagttg atgaaatgac agggatcagt    11040

cctgccaggg cacacgtggc tgcagccaac cttgtatcgg cttacgagca gacagtaaag    11100

gaagagcgta acttccaaaa gtcttttaat aatcatgtgc gaaccctgat tgcccgcgaa    11160

gaagttaccc ttggtttgat gcatttgtgg gatttgatgg aagctatcat tcagaaccct    11220

actagcaaac ctctgaccgc ccagctgttt ctggtggtgc aacacagcag agacaatgag    11280

gctttcagag aggcgctgct gaacatcacc gaacccgagg ggagatggtt gtatgatctt    11340

atcaacattc tacagagtat catagtgcag gagcggagcc tgggcctggc cgagaaggtg    11400

gctgccatca attactcggt tttgagcttg ggaaaatatt acgctcgcaa aatctacaag    11460

actccatacg ttcccataga caaggaggtg aagatagatg ggttctacat gcgcatgacg    11520

ctcaaggtct tgaccctgag cgatgatctt ggggtgtatc gcaatgacag aatgcatcgc    11580

gcggttagcg ccagcaggag gcgcgagtta agcgacaggg aactgatgca cagtttgcaa    11640

agagctctga ctggagctgg aaccgagggt gagaattact tcgacatggg agctgacttg    11700

cagtggcagc ctagtcgcag ggctctgagc gccgcgacgg caggatgtga gcttccttac    11760

atagaagagg cggatgaagg cgaggaggaa gagggcgagt acttggaaga ctgatggcac    11820

aacccgtgtt ttttgctaga tggaacagca agcaccggat cccgcaatgc gggcggcgct    11880

gcagagccag ccgtccggca ttaactcctc ggacgattgg acccaggcca tgcaacgtat    11940

catggcgttg acgactcgca accccgaagc ctttagacag caaccccagg ccaaccgtct    12000

atcggccatc atggaagctg tagtgccttc ccgctctaat cccactcatg agaaggtcct    12060

ggccatcgtg aacgcgttgg tggagaacaa agctattcgt ccagatgagg ccggactggt    12120

atacaacgct ctcttagaac gcgtggctcg ctacaacagt agcaatgtgc aaaccaattt    12180

ggaccgtatg ataacagatg tacgcgaagc cgtgtctcag cgcgaaaggt tccagcgtga    12240

tgccaacctg ggttcgctgg tggcgttaaa tgctttcttg agtactcagc ctgctaatgt    12300

gccgcgtggt caacaggatt atactaactt tttaagtgct ttgagactga tggtatcaga    12360

agtacctcag agcgaagtgt atcagtccgg tcctgattac ttctttcaga ctagcagaca    12420

gggcttgcag acggtaaatc tgagccaagc ttttaaaaac cttaaaggtt tgtggggagt    12480

gcatgccccg gtaggagaaa gagcaaccgt gtctagcttg ttaactccga actcccgcct    12540

attattactg ttggtagctc ctttcaccga cagcggtagc atcgaccgta attcctattt    12600

gggttaccta ctaaacctgt atcgcgaagc catagggcaa agtcaggtgg acgagcagac    12660

ctatcaagaa attacccaag tcagtcgcgc tttgggacag gaagacactg gcagtttgga    12720

agccactctg aacttcttgc ttaccaatcg gtctcaaaag atccctcctc aatatgctct    12780

tactgcggag gaggagagga tccttagata tgtgcagcag agcgtgggat tgtttctgat    12840

gcaagagggg gcaactccga ctgcagcact ggacatgaca gcgcgaaata tggagcccag    12900

catgtatgcc agtaaccgac ctttcattaa caaactgctg gactacttgc acagagctgc    12960

cgctatgaac tctgattatt tcaccaatgc catcttaaac ccgcactggc tgcccccacc    13020

tggtttctac acgggcgaat atgacatgcc cgaccctaat gacggatttc tgtgggacga    13080

cgtggacagc gatgtttttt cacctctttc tgatcatcgc acgtggaaaa aggaaggcgg    13140

cgatagaatg cattcttctg catcgctgtc cggggtcatg ggtgctaccg cggctgagcc    13200

cgagtctgca agtccttttc ctagtctacc cttttctcta cacagtgtac gtagcagcga    13260

agtgggtaga ataagtcgcc cgagtttaat gggcgaagag gagtatctaa acgattcctt    13320

gctcagaccg gcaagagaaa aaaatttccc aaacaatgga atagaaagtt tggtggataa    13380

aatgagtaga tggaagactt atgctcagga tcacagagac gagcctggga tcatggggat    13440

tacaagtaga gcgagccgta gacgccagcg ccatgacaga cagaggggtc ttgtgtggga    13500

cgatgaggat tcggccgatg atagcagcgt gctggacttg ggtgggagag gaaggggcaa    13560

cccgtttgct catttgcgcc ctcgcttggg tggtatgttg taaaaaaaaa taaaaaaaaa    13620

actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta    13680

taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt    13740

acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc    13800

cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttattcgg    13860

aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca    13920

ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca    13980

atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt    14040

ggggcggtca gctaaagacc atcatgcata ctaacatgcc aaacgtgaac gagtatatgt    14100

ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcccgac ggtgctgcag    14160

ttggggatac ttatgatcac aagcaggata ttttgaaata tgagtggttc gagtttactt    14220

tgccagaagg caacttttca gttactatga ctattgattt gatgaacaat gccatcatag    14280

ataattactt gaaagtgggt agacagaatg gagtgcttga aagtgacatt ggtgttaagt    14340

tcgacaccag gaacttcaag ctgggatggg atcccgaaac caagttgatc atgcctggag    14400

tgtatacgta tgaagccttc catcctgaca ttgtcttact gcctggctgc ggagtggatt    14460

ttaccgagag tcgtttgagc aaccttcttg gtatcagaaa aaaacagcca tttcaagagg    14520

gttttaagat tttgtatgaa gatttagaag gtggtaatat tccggccctc ttggatgtag    14580

atgcctatga gaacagtaag aaagaacaaa aagccaaaat agaagctgct acagctgctg    14640

cagaagctaa ggcaaacata gttgccagcg actctacaag ggttgctaac gctggagagg    14700

tcagaggaga caattttgcg ccaacacctg ttccgactgc agaatcatta ttggccgatg    14760

tgtctgaagg aacggacgtg aaactcacta ttcaacctgt agaaaaagat agtaagaata    14820

gaagctataa tgtgttggaa gacaaaatca acacagccta tcgcagttgg tatctttcgt    14880

acaattatgg cgatcccgaa aaaggagtgc gttcctggac attgctcacc acctcagatg    14940

tcacctgcgg agcagagcag gtctactggt cgcttccaga catgatgaag gatcctgtca    15000

ctttccgctc cactagacaa gtcagtaact accctgtggt gggtgcagag cttatgcccg    15060

tcttctcaaa gagcttctac aacgaacaag ctgtgtactc ccagcagctc cgccagtcca    15120

cctcgcttac gcacgtcttc aaccgctttc ctgagaacca gattttaatc cgtccgccgg    15180

cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc    15240

cgttgcgcag cagtatccgg ggagtccaac gtgtgaccgt tactgacgcc agacgccgca    15300

cctgtcccta cgtgtacaag gcactgggca tagtcgcacc gcgcgtcctt tcaagccgca    15360

ctttctaaaa aaaaaaaaaa tgtccattct tatctcgccc agtaataaca ccggttgggg    15420

tctgcgcgct ccaagcaaga tgtacggagg cgcacgcaaa cgttctaccc aacatcctgt    15480

ccgtgttcgc ggacattttc gcgctccatg gggcgccctc aagggccgca ctcgcgttcg    15540

aaccaccgtc gatgatgtaa tcgatcaggt ggttgccgac gcccgtaatt atactcctac    15600

tgcgcctaca tctactgtgg atgcagttat tgacagtgta gtggctgacg ctcgcaacta    15660

tgctcgacgt aagagccggc gaaggcgcat tgccagacgc caccgagcta ccactgccat    15720

gcgagccgca agagctctgc tacgaagagc tagacgcgtg gggcgaagag ccatgcttag    15780

ggcggccaga cgtgcagctt cgggcgccag cgccggcagg tcccgcaggc aagcagccgc    15840

tgtcgcagcg gcgactattg ccgacatggc ccaatcgcga agaggcaatg tatactgggt    15900

gcgtgacgct gccaccggtc aacgtgtacc cgtgcgcacc cgtccccctc gcacttagaa    15960

gatactgagc agtctccgat gttgtgtccc agcggcgagg atgtccaagc gcaaatacaa    16020

ggaagaaatg ctgcaggtta tcgcacctga agtctacggc caaccgttga aggatgaaaa    16080

aaaaccccgc aaaatcaagc gggttaaaaa ggacaaaaaa gaagaggaag atggcgatga    16140

tgggctggcg gagtttgtgc gcgagtttgc cccacggcga cgcgtgcaat ggcgtgggcg    16200

caaagttcga catgtgttga gacctggaac ttcggtggtc tttacacccg gcgagcgttc    16260

aagcgctact tttaagcgtt cctatgatga ggtgtacggg gatgatgata ttcttgagca    16320

ggcggctgac cgattaggcg agtttgctta tggcaagcgt agtagaataa cttccaagga    16380

tgagacagtg tcgataccct tggatcatgg aaatcccacc cctagtctta aaccggtcac    16440

tttgcagcaa gtgttacccg taactccgcg aacaggtgtt aaacgcgaag gtgaagattt    16500

gtatcccact atgcaactga tggtacccaa acgccagaag ttggaggacg ttttggagaa    16560

agtaaaagtg gatccagata ttcaacctga ggttaaagtg agacccatta agcaggtagc    16620

gcctggtctg ggggtacaaa ctgtagacat taagattccc actgaaagta tggaagtgca    16680

aactgaaccc gcaaagccta ctgccacctc cactgaagtg caaacggatc catggatgcc    16740

catgcctatt acaactgacg ccgccggtcc cactcgaaga tcccgacgaa agtacggtcc    16800

agcaagtctg ttgatgccca attatgttgt acacccatct attattccta ctcctggtta    16860

ccgaggcact cgctactatc gcagccgaaa cagtacctcc cgccgtcgcc gcaagacacc    16920

tgcaaatcgc agtcgtcgcc gtagacgcac aagcaaaccg actcccggcg ccctggtgcg    16980

gcaagtgtac cgcaatggta gtgcggaacc tttgacactg ccgcgtgcgc gttaccatcc    17040

gagtatcatc acttaatcaa tgttgccgct gcctccttgc agatatggcc ctcacttgtc    17100

gccttcgcgt tcccatcact ggttaccgag gaagaaactc gcgccgtaga agagggatgt    17160

tgggacgcgg aatgcgacgc tacaggcgac ggcgtgctat ccgcaagcaa ttgcggggtg    17220

gttttttacc agccttaatt ccaattatcg ctgctgcaat tggcgcgata ccaggcatag    17280

cttccgtggc ggttcaggcc tcgcaacgac attgacattg gaaaaaaacg tataaataaa    17340

aaaaaaaaaa tacaatggac tctgacactc ctggtcctgt gactatgttt tcttagagat    17400

ggaagacatc aatttttcat ccttggctcc gcgacacggc acgaagccgt acatgggcac    17460

ctggagcgac atcggcacga gccaactgaa cgggggcgcc ttcaattgga gcagtatctg    17520

gagcgggctt aaaaattttg gctcaaccat aaaaacatac gggaacaaag cttggaacag    17580

cagtacagga caggcgctta gaaataaact taaagaccag aacttccaac aaaaagtagt    17640

cgatgggata gcttccggca tcaatggagt ggtagatttg gctaaccagg ctgtgcagaa    17700

aaagataaac agtcgtttgg acccgccgcc agcaacccca ggtgaaatgc aagtggagga    17760

agaaattcct ccgccagaaa aacgaggcga caagcgtccg cgtcccgatt tggaagagac    17820

gctggtgacg cgcgtagatg aaccgccttc ttatgaggaa gcaacgaagc ttggaatgcc    17880

caccactaga ccgatagccc caatggccac cggggtgatg aaaccttctc agttgcatcg    17940

acccgtcacc ttggatttgc cccctccccc tgctgctact gctgtacccg cttctaagcc    18000

tgtcgctgcc ccgaaaccag tcgccgtagc caggtcacgt cccgggggcg ctcctcgtcc    18060

aaatgcgcac tggcaaaata ctctgaacag catcgtgggt ctaggcgtgc aaagtgtaaa    18120

acgccgtcgc tgcttttaat taaatatgga gtagcgctta acttgcctat ctgtgtatat    18180

gtgtcattac acgccgtcac agcagcagag gaaaaaagga agaggtcgtg cgtcgacgct    18240

gagttacttt caagatggcc accccatcga tgctgcccca atgggcatac atgcacatcg    18300

ccggacagga tgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag    18360

acacctactt caatctggga aataagttta gaaatcccac cgtagcgccg acccacgatg    18420

tgaccaccga ccgtagccag cggctcatgt tgcgcttcgt gcccgttgac cgggaggaca    18480

atacatactc ttacaaagtg cggtacaccc tggccgtggg cgacaacaga gtgctggata    18540

tggccagcac gttctttgac attaggggtg tgttggacag aggtcccagt ttcaaaccct    18600

attctggtac ggcttacaac tccctggctc ctaaaggcgc tccaaataca tctcagtgga    18660

ttgcagaagg tgtaaaaaat acaactggtg aggaacacgt aacagaagag gaaaccaata    18720

ctactactta cacttttggc aatgctcctg taaaagctga agctgaaatt acaaaagaag    18780

gactcccagt aggtttggaa gtttcagatg aagaaagtaa accgatttat gctgataaaa    18840

catatcagcc agaacctcag ctgggagatg aaacttggac tgaccttgat ggaaaaaccg    18900

aaaagtatgg aggcagggct ctcaaacccg atactaagat gaaaccatgc tacgggtcct    18960

ttgccaaacc tactaatgtg aaaggcggtc aggcaaaaca aaaaacaacg gagcagccaa    19020

atcagaaagt cgaatatgat atcgacatgg agttttttga tgcggcatcg cagaaaacaa    19080

acttaagtcc taaaattgtc atgtatgcag aaaatgtaaa tttggaaact ccagacactc    19140

atgtagtgta caaacctgga acagaagaca caagttccga agctaatttg ggacaacaat    19200

ctatgcccaa cagacccaac tacattggct tcagagataa ctttattgga cttatgtact    19260

ataacagtac tggtaacatg ggggtgctgg ctggtcaagc gtctcagtta aatgcagtgg    19320

ttgacttgca ggacagaaac acagaacttt cttaccaact cttgcttgac tctctgggcg    19380

acagaaccag atactttagc atgtggaatc aggctgtgga cagttatgat cctgatgtac    19440

gtgttattga aaatcatggt gtggaagatg aacttcccaa ctactgtttt ccactggacg    19500

gcataggtgt tccaacaacc agttacaaat caatagttcc aaatggagac aatgcgccta    19560

attggaagga acctgaagta aatggaacaa gtgagatcgg acagggtaat ttgtttgcca    19620

tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat    19680

atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca    19740

cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca    19800

ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta    19860

acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca    19920

tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca    19980

cttatgagtg gaactttagg aaggatgtga acatggttct acagagttcc ctcggtaacg    20040

acctgcgggt agatggcgcc agcatcagtt tcacgagcat caacctctat gctacttttt    20100

tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg    20160

atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg    20220

caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat    20280

ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctactttg    20340

tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga    20400

aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc    20460

ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca    20520

acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg    20580

gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc    20640

ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac    20700

cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgccaaggtc    20760

aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta    20820

cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctcg agcaacttca    20880

tgtctatggg ggcccttaca gacttgggac agaatatgct ctatgccaac tcagctcatg    20940

ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct    21000

tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct    21060

acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc    21120

aaatagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca    21180

gagccattgt ccaagacctg ggttgcggac cctatttttt gggaacctac gataagcgct    21240

tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg    21300

agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc    21360

tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg    21420

agggtctcct gcgccgcagc gctcttgcta ccaaggaccg ctgtattacg ctggaaaaat    21480

ctacccagac cgtgcagggt ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc    21540

ttcacgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc    21600

taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca    21660

atcaaaaagc actctaccat tttcttaata cccattcgcc ttattttcgc tcccatcgta    21720

cacacatcga aagggccact gcgttcgacc gtatggatgt tcaataatga ctcatgtaaa    21780

caacgtgttc aataaacatc actttatttt tttacatgta tcaaggctct gcattactta    21840

tttatttaca agtcgaatgg gttctgacga gaatcagaat gacccgcagg cagtgatacg    21900

ttgcggaact gatacttggg ttgccacttg aattcgggaa tcaccaactt gggaaccggt    21960

atatcgggca ggatgtcact ccacagcttt ctggtcagct gcaaagctcc aagcaggtca    22020

ggagccgaaa tcttgaaatc acaattagga ccagtgcttt gagcgcgaga gttgcggtac    22080

accggattgc agcactgaaa caccatcagc gacggatgtc tcacgcttgc cagcacggtg    22140

ggatctgcaa tcatgcccac atccagatct tcagcattgg caatgctgaa cggggtcatc    22200

ttgcaggtct gcctacccat ggcgggcacc caattaggct tgtggttgca atcgcagtgc    22260

agggggatca gtatcatctt ggcctgatcc tgtctgattc ctggatacac ggctctcatg    22320

aaagcatcat attgcttgaa agcctgctgg gctttactac cctcggtata aaacatcccg    22380

caggacctgc tcgaaaactg gttagctgca cagccggcat cattcacaca gcagcgggcg    22440

tcattgttag ctatttgcac cacacttctg ccccagcggt tttgggtgat tttggttcgc    22500

tcgggattct cctttaaggc tcgttgtccg ttctcgctgg ccacatccat ctcgataatc    22560

tgctccttct gaatcataat attgccatgc aggcacttca gcttgccctc ataatcattg    22620

cagccatgag gccacaacgc acagcctgta cattcccaat tatggtgggc gatctgagaa    22680

aaagaatgta tcattccctg cagaaatctt cccatcatcg tgctcagtgt cttgtgacta    22740

gtgaaagtta actggatgcc tcggtgctcc tcgtttacgt actggtgaca gatgcgcttg    22800

tattgttcgt gttgctcagg cattagttta aaagaggttc taagttcgtt atccagcctg    22860

tacttctcca tcagcagaca catcacttcc atgcctttct cccaagcaga caccaggggc    22920

aagctaatcg gattcttaac agtgcaggca gcagctcctt tagccagagg gtcatcttta    22980

gcgatcttct caatgcttct tttgccatcc ttctcaacga tgcgcacggg cgggtagctg    23040

aaacccactg ctacaagttg cgcctcttct ctttcttctt cgctgtcttg actgatgtct    23100

tgcatgggga tatgtttggt cttccttggc ttctttttgg ggggtatcgg aggaggagga    23160

ctgtcgctcc gttccggaga cagggaggat tgtgacgttt cgctcaccat taccaactga    23220

ctgtcggtag aagaacctga ccccacacgg cgacaggtgt ttctcttcgg gggcagaggt    23280

ggaggcgatt gcgaagggct gcggtccgac ctggaaggcg gatgactggc agaacccctt    23340

ccgcgttcgg gggtgtgctc cctgtggcgg tcgcttaact gatttccttc gcggctggcc    23400

attgtgttct cctaggcaga gaaacaacag acatggaaac tcagccattg ctgtcaacat    23460

cgccacgagt gccatcacat ctcgtcctca gcgacgagga aaaggagcag agcttaagca    23520

ttccaccgcc cagtcctgcc accacctcta ccctagaaga taaggaggtc gacgcatctc    23580

atgacatgca gaataaaaaa gcgaaagagt ctgagacaga catcgagcaa gacccgggct    23640

atgtgacacc ggtggaacac gaggaagagt tgaaacgctt tctagagaga gaggatgaaa    23700

actgcccaaa acaacgagca gataactatc accaagatgc tggaaatagg gatcagaaca    23760

ccgactacct catagggctt gacggggaag acgcgctcct taaacatcta gcaagacagt    23820

cgctcatagt caaggatgca ttattggaca gaactgaagt gcccatcagt gtggaagagc    23880

tcagccgcgc ctacgagctt aacctctttt cacctcgtac tccccccaaa cgtcagccaa    23940

acggcacctg cgagccaaat cctcgcttaa acttttatcc agcttttgct gtgccagaag    24000

tactggctac ctatcacatc ttttttaaaa atcaaaaaat tccagtctcc tgccgcgcta    24060

atcgcacccg cgccgatgcc ctactcaatc tgggacctgg ttcacgctta cctgatatag    24120

cttccttgga agaggttcca aagatcttcg agggtctggg caataatgag actcgggccg    24180

caaatgctct gcaaaaggga gaaaatggca tggatgagca tcacagcgtt ctggtggaat    24240

tggaaggcga taatgccaga ctcgcagtac tcaagcgaag catcgaggtc acacacttcg    24300

catatcccgc tgtcaacctg ccccctaaag tcatgacggc ggtcatggac cagttactca    24360

ttaagcgcgc aagtcccctt tcagaagaca tgcatgaccc agatgcctgt gatgagggta    24420

aaccagtggt cagtgatgag cagctaaccc gatggctggg caccgactct cccagggatt    24480

tggaagagcg tcgcaagctt atgatggccg tggtgctggt taccgtagaa ctagagtgtc    24540

tccgacgttt ctttaccgat tcagaaacct tgcgcaaact cgaagagaat ctgcactaca    24600

cttttagaca cggctttgtg cggcaggcat gcaagatatc taacgtggaa ctcaccaacc    24660

tggtttccta catgggtatt ctgcatgaga atcgcctagg acaaagcgtg ctgcacagca    24720

ccctgaaggg ggaagcccgc cgtgattaca tccgcgattg tgtctatctg tacctgtgcc    24780

acacgtggca aaccggcatg ggtgtatggc agcaatgttt agaagaacag aacttgaaag    24840

agcttgacaa gctcttacag aaatctctta aggttctgtg gacagggttc gacgagcgca    24900

ccgtcgcttc cgacctggca gacctcatct tcccagagcg tctcagggtt actttgcgaa    24960

acggattgcc tgactttatg agccagagca tgcttaacaa ttttcgctct ttcatcctgg    25020

aacgctccgg tatcctgccc gccacctgct gcgcactgcc ctccgacttt gtgcctctca    25080

cctaccgcga gtgccccccg ccgctatgga gtcactgcta cctgttccgt ctggccaact    25140

atctctccta ccactcggat gtgatcgagg atgtgagcgg agacggcttg ctggagtgtc    25200

actgccgctg caatctgtgc acgccccacc ggtccctagc ttgcaacccc cagttgatga    25260

gcgaaaccca gataataggc acctttgaat tgcaaggccc cagcagccaa ggcgatgggt    25320

cttctcctgg gcaaagttta aaactgaccc cgggactgtg gacctccgcc tacttgcgca    25380

agtttgctcc ggaagattac cacccctatg aaatcaagtt ctatgaggac caatcacagc    25440

ctccaaaggc cgaactttcg gcctgcgtca tcacccaggg ggcaattctg gcccaattgc    25500

aagccatcca aaaatcccgc caagaatttc tactgaaaaa gggtaagggg gtctaccttg    25560

acccccagac cggcgaggaa ctcaacacaa ggttccctca ggatgtccca acgacgagaa    25620

aacaagaagt tgaaggtgca gccgccgccc ccagaagata tggaggaaga ttgggacagt    25680

caggcagagg aggcggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag    25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg    25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt    25860

cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc    25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc    25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat    26040

ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat    26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa    26160

accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac    26220

agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc    26280

catcttccag cagagtcggg gtcaagagca ggaactgaaa ataaaaaacc gatctctgcg    26340

ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga    26400

ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac    26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca    26520

cgccttacat gtggagttat caaccccaaa tgggattggc ggcaggcgcc tcccaggact    26580

actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata    26640

tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc    26700

aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca    26760

ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc    26820

agttagctgg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga    26880

tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac    26940

gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg    27000

ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc    27060

aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc    27120

attacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg    27180

attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg    27240

ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca    27300

ccctcaaggt ccggcccacg gagtgcggat ttctatcgaa ggcaaaatag actctcgcct    27360

gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt    27420

ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg    27480

tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg    27540

gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct    27600

ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta    27660

ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg    27720

tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct    27780

acctatacac accttgcttc actttcttag tggtgttgtg gtattggttt aaaaaatggg    27840

gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga    27900

tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg    27960

catctgtgga gttcatcgcc tctcttacga acttggcccc caacgacaaa aatttacctg    28020

catggtggga atcaacccca tagttatcac ccagcaaagt ggagatacta agggttgcat    28080

tcactgctcc tgcgattcca tcgagtgcac ctacaccctg ctgaagaccc tatgcggcct    28140

aagagacctg ctaccaatga attaaaaaat gattaataaa aaatcactta cttgaaatca    28200

gcaataaggt ctctgttgaa attttctccc agcagcacct cacttccctc ttcccaactc    28260

tggtattcta aaccccgttc agcggcatac tttctccata ctttaaaggg gatgtcaaat    28320

tttagctcct ctcctgtacc cacaatcttc atgtctttct tcccagatga ccaagagagt    28380

ccggctcagt gactccttca accctgtcta cccctatgaa gatgaaagca cctcccaaca    28440

cccctttata aacccagggt ttatttcccc aaatggcttc acacaaagcc caaacggagt    28500

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28560

gggaggggga cttacagtgg atgacaccaa cggttttttg aaagaaaaca taagtgccac    28620

cacaccactc gttaagactg gtcactctat aggtttacca ctaggagccg gattgggaac    28680

gaatgaaaat aaactttgta tcaaattagg acaaggactt acattcaatt caaacaacat    28740

ttgcattgat gacaatatta acaccttatg gacaggagtc aaccccaccg aagccaactg    28800

tcaaatcatg aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac    28860

tggagcacta gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct    28920

aactacacac agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt    28980

actaactaga ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc    29040

tactggtgcc attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa    29100

tgataattct agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga    29160

tcgcactgct tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga    29220

gacatcatat tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca    29280

aacctctgct acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga    29340

ctgacaaata aagtttgcga tcgccaggcc caccatgggt tggagctgta ttattctctt    29400

cctcgtcgcc accgcgaccg gagtgcattc cgagctcgtg atgacccagt caccatcatc    29460

cttgaccgtg actgcgggcg agaaggtcac gatgtcatgc aagtcgtcac aaagcctgct    29520

gaactccggc aatcagaaga attacctgac ctggtaccag cagaaaccgg gtcagccgcc    29580

aaaactgctg atctactggg catccacccg ggaaagcggg gtccctgacc ggttcactgg    29640

atcaggatca ggaaccgact ttaccctcac gatctcaagc gtccaagccg aggacttggc    29700

tgtgtactac tgccaaaatg actactcgta ccccctgact ttcggagctg ggaccaagct    29760

ggagatcaaa ggcggcggag ggtccggagg aggggggtcg ggaggggggg gaagcgaggt    29820

gcagctgctg gaacagagcg gagccgagct ggtgagacca ggcaccagcg tgaaaatctc    29880

gtgcaaggcc tcggggtacg ctttcacgaa ctactggttg ggttgggtga agcagcggcc    29940

gggtcatgga ctggagtgga tcggagacat ctttcccgga agcggaaata tccattacaa    30000

cgaaaagttt aaaggcaagg ccacccttac tgcggataag tcaagctcca ccgcttacat    30060

gcaactgtcc tcactgactt ttgaagacag cgctgtgtat ttctgcgctc gcctgcgcaa    30120

ttgggatgaa cctatggact actggggcca aggaaccacc gtgactgtgt cgtcgggagg    30180

gggaggctca caagtgcagc tgcagcagtc aggtgcagaa ttggccaggc cgggagccag    30240

cgtgaagatg tcgtgcaaag cctccggcta caccttcact cgctacacta tgcattgggt    30300

gaaacagcgg ccgggacaag ggctggagtg gatcggatac atcaatccat caagaggtta    30360

caccaactac aatcagaagt tcaaggacaa ggctaccctg acgactgata agagctcgtc    30420

aactgcatac atgcagctgt cgagcctgac cagcgaggat tccgccgtgt actactgcgc    30480

gagatactat gatgaccact actgcttgga ttactggggc caagggacca ctctgaccgt    30540

gtcctccggc ggagggggct cgggcggcgg gggctcgggg ggcggcggca gcgacatcgt    30600

gctgacgcag agccccgcaa tcatgtcagc ctcccctggc gaaaaagtga cgatgacctg    30660

ctccgcttcc tcatcagtct cctacatgaa ctggtatcaa cagaagagcg gaacctcgcc    30720

gaagcgctgg atctacgata cctccaaact ggccagcgga gtgccggcgc attttcgggg    30780

atcgggcagc ggtacctcct actcgctcac catctcagga atggaagccg aagacgccgc    30840

cacctactac tgccagcagt ggtcctcaaa cccattcacc ttcggatccg gcactaagct    30900

ggaaatcaac cgcgggagcg gagcgactaa cttcagcttg ctcaagcaag ccggagatgt    30960

cgaggagaac ccgggacctg gttggtcgtg catcatccta ttccttgtcg cgaccgcaac    31020

tggcgtccat tccgacatcg tcatgaccca atccccagat tcgctggcgg tgtcgcttgg    31080

ggaacgggca accatcaact gcaagagctc gcagtcactg ctatacagcc ggaatcagaa    31140

aaactacctg gcgtggtacc agcaaaagcc gggtcagcct ccgaagctgc tgattttctg    31200

ggcctcaacc cgggaatccg gagtccctga cagattcagc gggtccggat tcgggaccga    31260

cttcactctg actatttcga gcctgcaagc agaagatgtg gcagtgtact attgccaaca    31320

gtatttttca tacccgctga ccttcggcca gggtacgaag gtggagatca agggtggagg    31380

gggtagcggc gggggaggca gcggcggggg gggaagccag gtgcagctgg tccaatcagg    31440

cgccgaggtc aagaaacctg gagcgtcggt caaggtctcc tgcaagacta gccgctacac    31500

ttttaccgaa tacaccatcc actgggtcag acaggcgccc ggtcagcgcc tggagtggat    31560

cggcgggatc aacccgaata atggaatccc gaactacaat caaaaattca aaggccgcgt    31620

gactatcacc gtggatactt cagcctcaac tgcttacatg gaactgtcat cgctgagatc    31680

agaggacact gcggtctact actgtgcgcg cagaagaatc gcttacggat acgacgaggg    31740

gcacgcaatg gactactggg gacagggaac cctggtgacc gtgtcgtcag gcggaggagg    31800

atcggatgtg cagttggtgc agtcgggcgc cgaagtgaaa aaaccggggg cctcagtgaa    31860

agtgtcctgc aaggcctccg gatacacctt cacccgctac actatgcact gggtcaggca    31920

ggcgcccggg cagggcctgg agtggatcgg gtatatcaac ccgtcaaggg gatacactaa    31980

ctacgccgac tccgtgaagg gaagattcac tatcaccact gacaaatcaa cttcgacggc    32040

gtatatggaa ctgtcatcct tgagatcgga agataccgcg acctactact gtgcgcgcta    32100

ctacgatgac cattactgcc tcgattactg gggacagggc accacggtga ccgtctcatc    32160

aggagaagga acttcaactg gttccggagg ctccggcggc tcaggcggcg ctgacgacat    32220

tgtgctgacc cagagcccgg cgaccctgtc actctcgccg ggggaaaggg ctactctgtc    32280

atgcagagcg tcacaatcgg tctcatacat gaactggtac cagcagaaac cgggcaaggc    32340

tccaaagcgg tggatctacg atacttcgaa ggtggcttca ggagtgccgg ctcgcttcag    32400

cggatccggc tcgggaaccg attacagctt gaccattaac tcgctggagg cggaggatgc    32460

agcgacctac tactgtcaac aatggtcctc gaacccactc acttttgggg gcgggaccaa    32520

ggtggagatt aagtaggcta gcttgactga ctgagataca gcgtaccttc agctcacaga    32580

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg    32640

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa    32700

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga    32760

ggttttttaa agcaagtaaa acctctacaa atgtggtagt cgtcagctat cctgcaggaa    32820

cttgtttatt tgaaaatcaa ttcacaaaat ccgagtagtt attttgcctc ccccttccca    32880

tttaacagaa tacaccaatc tctccccacg cacagcttta aacatttgga taccattaga    32940

tatagacatg gttttagatt ccacattcca aacagtttca gagcgagcca atctggggtc    33000

agtgatagat aaaaatccat cgggatagtc ttttaaagcg ctttcacagt ccaactgctg    33060

cggatgcgac tccggagtct ggatcacggt catctggaag aagaacgatg ggaatcataa    33120

tccgaaaacg gtatcggacg attgtgtctc atcaaaccca caagcagccg ctgtctgcgt    33180

cgctccgtgc gactgctgtt tatgggatca gggtccacag tgtcctgaag catgatttta    33240

atagccctta acatcaactt tctggtgcga tgcgcgcagc aacgcattct gatttcactc    33300

aaatctttgc agtaggtaca acacattatt acaatattgt ttaataaacc ataattaaaa    33360

gcgctccagc caaaactcat atctgatata atcgcccctg catgaccatc ataccaaagt    33420

ttaatataaa ttaaatgacg ttccctcaaa aacacactac ccacatacat gatctctttt    33480

ggcatgtgca tattaacaat ctgtctgtac catggacaac gttggttaat catgcaaccc    33540

aatataacct tccggaacca cactgccaac accgctcccc cagccatgca ttgaagtgaa    33600

ccctgctgat tacaatgaca atgaagaacc caattctctc gaccgtgaat cacttgagaa    33660

tgaaaaatat ctatagtggc acaacataga cataaatgca tgcatcttct cataattttt    33720

aactcctcag gatttagaaa catatcccag ggaataggaa gctcttgcag aacagtaaag    33780

ctggcagaac aaggaagacc acgaacacaa cttacactat gcatagtcat agtatcacaa    33840

tctggcaaca gcgggtggtc ttcagtcata gaagctcggg tttcattttc ctcacaacgt    33900

ggtaactggg ctctggtgta agggtgatgt ctggcgcatg atgtcgagcg tgcgcgcaac    33960

cttgtcataa tggagttgct tcctgacatt ctcgtatttt gtatagcaaa acgcggccct    34020

ggcagaacac actcttcttc gccttctatc ctgccgctta gcgtgttccg tgtgatagtt    34080

caagtacaac cacactctta agttggtcaa aagaatgctg gcttcagttg taatcaaaac    34140

tccatcgcat ctaatcgttc tgaggaaatc atccaagcaa tgcaactgga ttgtgtttca    34200

agcaggagag gagagggaag agacggaaga accatgttaa tttttattcc aaacgatctc    34260

gcagtacttc aaattgtaga tcgcgcagat ggcatctctc gcccccactg tgttggtgaa    34320

aaagcacagc tagatcaaaa gaaatgcgat tttcaaggtg ctcaacggtg gcttccagca    34380

aagcctccac gcgcacatcc aagaacaaaa gaataccaaa agaaggagca ttttctaact    34440

cctcaatcat catattacat tcctgcacca ttcccagata attttcagct ttccagcctt    34500

gaattattcg tgtcagttct tgtggtaaat ccaatccaca cattacaaac aggtcccgga    34560

gggcgccctc caccaccatt cttaaacaca ccctcataat gacaaaatat cttgctcctg    34620

tgtcacctgt agcgaattga gaatggcaac atcaattgac atgcccttgg ctctaagttc    34680

ttctttaagt tctagttgta aaaactctct catattatca ccaaactgct tagccagaag    34740

ccccccggga acaagagcag gggacgctac agtgcagtac aagcgcagac ctccccaatt    34800

ggctccagca aaaacaagat tggaataagc atattgggaa ccgccagtaa tatcatcgaa    34860

gttgctggaa atataatcag gcagagtttc ttgtaaaaat tgaataaaag aaaaatttgc    34920

caaaaaaaca ttcaaaacct ctgggatgca aatgcaatag gttaccgcgc tgcgctccaa    34980

cattgttagt tttgaattag tctgcaaaaa taaaaaaaaa aacaagcgtc atatcatagt    35040

agcctgacga acagatggat aaatcagtct ttccatcaca agacaagcca cagggtctcc    35100

agctcgaccc tcgtaaaacc tgtcatcatg attaaacaac agcaccgaaa gttcctcgcg    35160

gtgaccagca tgaataattc ttgatgaagc atacaatcca gacatgttag catcagttaa    35220

cgagaaaaaa cagccaacat agcctttggg tataattatg cttaatcgta agtatagcaa    35280

agccacccct cgcggataca aagtaaaagg cacaggagaa taaaaaatat aattatttct    35340

ctgctgctgt tcaggcaacg tcgcccccgg tccctctaaa tacacataca aagcctcatc    35400

agccatggct taccagacaa agtacagcgg gcacacaaag cacaagctct aaagtgactc    35460

tccaacctct ccacaatata tatatacaca agccctaaac tgacgtaatg ggagtaaagt    35520

gtaaaaaatc ccgccaaacc caacacacac cccgaaactg cgtcaccagg gaaaagtaca    35580

gtttcacttc cgcaatccca acaggcgtaa cttcctcttt ctcacggtac gtgatatccc    35640

actaacttgc aacgtcattt tcccacggtc gcaccgcccc ttttagccgt taaccccaca    35700

gccaatcacc acacgatcca cactttttaa aatcacctca tttacatatt ggcaccattc    35760

catctataag gtatattata tagataga                                       35788


<210>  121
<211>  1540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-618 EpCam BiTE nucleic acid sequence

<400>  121
atgggttgga gctgtattat tctcttcctc gtcgccaccg cgaccggagt gcattccgag       60

ctcgtgatga cccagtcacc atcatccttg accgtgactg cgggcgagaa ggtcacgatg      120

tcatgcaagt cgtcacaaag cctgctgaac tccggcaatc agaagaatta cctgacctgg      180

taccagcaga aaccgggtca gccgccaaaa ctgctgatct actgggcatc cacccgggaa      240

agcggggtcc ctgaccggtt cactggatca ggatcaggaa ccgactttac cctcacgatc      300

tcaagcgtcc aagccgagga cttggctgtg tactactgcc aaaatgacta ctcgtacccc      360

ctgactttcg gagctgggac caagctggag atcaaaggcg gcggagggtc cggaggaggg      420

gggtcgggag gggggggaag cgaggtgcag ctgctggaac agagcggagc cgagctggtg      480

agaccaggca ccagcgtgaa aatctcgtgc aaggcctcgg ggtacgcttt cacgaactac      540

tggttgggtt gggtgaagca gcggccgggt catggactgg agtggatcgg agacatcttt      600

cccggaagcg gaaatatcca ttacaacgaa aagtttaaag gcaaggccac ccttactgcg      660

gataagtcaa gctccaccgc ttacatgcaa ctgtcctcac tgacttttga agacagcgct      720

gtgtatttct gcgctcgcct gcgcaattgg gatgaaccta tggactactg gggccaagga      780

accaccgtga ctgtgtcgtc gggaggggga ggctcacaag tgcagctgca gcagtcaggt      840

gcagaattgg ccaggccggg agccagcgtg aagatgtcgt gcaaagcctc cggctacacc      900

ttcactcgct acactatgca ttgggtgaaa cagcggccgg gacaagggct ggagtggatc      960

ggatacatca atccatcaag aggttacacc aactacaatc agaagttcaa ggacaaggct     1020

accctgacga ctgataagag ctcgtcaact gcatacatgc agctgtcgag cctgaccagc     1080

gaggattccg ccgtgtacta ctgcgcgaga tactatgatg accactactg cttggattac     1140

tggggccaag ggaccactct gaccgtgtcc tccggcggag ggggctcggg cggcgggggc     1200

tcggggggcg gcggcagcga catcgtgctg acgcagagcc ccgcaatcat gtcagcctcc     1260

cctggcgaaa aagtgacgat gacctgctcc gcttcctcat cagtctccta catgaactgg     1320

tatcaacaga agagcggaac ctcgccgaag cgctggatct acgatacctc caaactggcc     1380

agcggagtgc cggcgcattt tcggggatcg ggcagcggta cctcctactc gctcaccatc     1440

tcaggaatgg aagccgaaga cgccgccacc tactactgcc agcagtggtc ctcaaaccca     1500

ttcaccttcg gatccggcac taagctggaa atcaaccgcg                           1540


<210>  122
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-618 FAP BiTE nucleic acid sequence

<400>  122
atgggttggt cgtgcatcat cctattcctt gtcgcgaccg caactggcgt ccattccgac       60

atcgtcatga cccaatcccc agattcgctg gcggtgtcgc ttggggaacg ggcaaccatc      120

aactgcaaga gctcgcagtc actgctatac agccggaatc agaaaaacta cctggcgtgg      180

taccagcaaa agccgggtca gcctccgaag ctgctgattt tctgggcctc aacccgggaa      240

tccggagtcc ctgacagatt cagcgggtcc ggattcggga ccgacttcac tctgactatt      300

tcgagcctgc aagcagaaga tgtggcagtg tactattgcc aacagtattt ttcatacccg      360

ctgaccttcg gccagggtac gaaggtggag atcaagggtg gagggggtag cggcggggga      420

ggcagcggcg gggggggaag ccaggtgcag ctggtccaat caggcgccga ggtcaagaaa      480

cctggagcgt cggtcaaggt ctcctgcaag actagccgct acacttttac cgaatacacc      540

atccactggg tcagacaggc gcccggtcag cgcctggagt ggatcggcgg gatcaacccg      600

aataatggaa tcccgaacta caatcaaaaa ttcaaaggcc gcgtgactat caccgtggat      660

acttcagcct caactgctta catggaactg tcatcgctga gatcagagga cactgcggtc      720

tactactgtg cgcgcagaag aatcgcttac ggatacgacg aggggcacgc aatggactac      780

tggggacagg gaaccctggt gaccgtgtcg tcaggcggag gaggatcgga tgtgcagttg      840

gtgcagtcgg gcgccgaagt gaaaaaaccg ggggcctcag tgaaagtgtc ctgcaaggcc      900

tccggataca ccttcacccg ctacactatg cactgggtca ggcaggcgcc cgggcagggc      960

ctggagtgga tcgggtatat caacccgtca aggggataca ctaactacgc cgactccgtg     1020

aagggaagat tcactatcac cactgacaaa tcaacttcga cggcgtatat ggaactgtca     1080

tccttgagat cggaagatac cgcgacctac tactgtgcgc gctactacga tgaccattac     1140

tgcctcgatt actggggaca gggcaccacg gtgaccgtct catcaggaga aggaacttca     1200

actggttccg gaggctccgg cggctcaggc ggcgctgacg acattgtgct gacccagagc     1260

ccggcgaccc tgtcactctc gccgggggaa agggctactc tgtcatgcag agcgtcacaa     1320

tcggtctcat acatgaactg gtaccagcag aaaccgggca aggctccaaa gcggtggatc     1380

tacgatactt cgaaggtggc ttcaggagtg ccggctcgct tcagcggatc cggctcggga     1440

accgattaca gcttgaccat taactcgctg gaggcggagg atgcagcgac ctactactgt     1500

caacaatggt cctcgaaccc actcactttt gggggcggga ccaaggtgga gattaag        1557


<210>  123
<211>  3169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-618 Transgene cassette

<400>  123
caggcccacc atgggttgga gctgtattat tctcttcctc gtcgccaccg cgaccggagt       60

gcattccgag ctcgtgatga cccagtcacc atcatccttg accgtgactg cgggcgagaa      120

ggtcacgatg tcatgcaagt cgtcacaaag cctgctgaac tccggcaatc agaagaatta      180

cctgacctgg taccagcaga aaccgggtca gccgccaaaa ctgctgatct actgggcatc      240

cacccgggaa agcggggtcc ctgaccggtt cactggatca ggatcaggaa ccgactttac      300

cctcacgatc tcaagcgtcc aagccgagga cttggctgtg tactactgcc aaaatgacta      360

ctcgtacccc ctgactttcg gagctgggac caagctggag atcaaaggcg gcggagggtc      420

cggaggaggg gggtcgggag gggggggaag cgaggtgcag ctgctggaac agagcggagc      480

cgagctggtg agaccaggca ccagcgtgaa aatctcgtgc aaggcctcgg ggtacgcttt      540

cacgaactac tggttgggtt gggtgaagca gcggccgggt catggactgg agtggatcgg      600

agacatcttt cccggaagcg gaaatatcca ttacaacgaa aagtttaaag gcaaggccac      660

ccttactgcg gataagtcaa gctccaccgc ttacatgcaa ctgtcctcac tgacttttga      720

agacagcgct gtgtatttct gcgctcgcct gcgcaattgg gatgaaccta tggactactg      780

gggccaagga accaccgtga ctgtgtcgtc gggaggggga ggctcacaag tgcagctgca      840

gcagtcaggt gcagaattgg ccaggccggg agccagcgtg aagatgtcgt gcaaagcctc      900

cggctacacc ttcactcgct acactatgca ttgggtgaaa cagcggccgg gacaagggct      960

ggagtggatc ggatacatca atccatcaag aggttacacc aactacaatc agaagttcaa     1020

ggacaaggct accctgacga ctgataagag ctcgtcaact gcatacatgc agctgtcgag     1080

cctgaccagc gaggattccg ccgtgtacta ctgcgcgaga tactatgatg accactactg     1140

cttggattac tggggccaag ggaccactct gaccgtgtcc tccggcggag ggggctcggg     1200

cggcgggggc tcggggggcg gcggcagcga catcgtgctg acgcagagcc ccgcaatcat     1260

gtcagcctcc cctggcgaaa aagtgacgat gacctgctcc gcttcctcat cagtctccta     1320

catgaactgg tatcaacaga agagcggaac ctcgccgaag cgctggatct acgatacctc     1380

caaactggcc agcggagtgc cggcgcattt tcggggatcg ggcagcggta cctcctactc     1440

gctcaccatc tcaggaatgg aagccgaaga cgccgccacc tactactgcc agcagtggtc     1500

ctcaaaccca ttcaccttcg gatccggcac taagctggaa atcaaccgcg ggagcggagc     1560

gactaacttc agcttgctca agcaagccgg agatgtcgag gagaacccgg gacctggttg     1620

gtcgtgcatc atcctattcc ttgtcgcgac cgcaactggc gtccattccg acatcgtcat     1680

gacccaatcc ccagattcgc tggcggtgtc gcttggggaa cgggcaacca tcaactgcaa     1740

gagctcgcag tcactgctat acagccggaa tcagaaaaac tacctggcgt ggtaccagca     1800

aaagccgggt cagcctccga agctgctgat tttctgggcc tcaacccggg aatccggagt     1860

ccctgacaga ttcagcgggt ccggattcgg gaccgacttc actctgacta tttcgagcct     1920

gcaagcagaa gatgtggcag tgtactattg ccaacagtat ttttcatacc cgctgacctt     1980

cggccagggt acgaaggtgg agatcaaggg tggagggggt agcggcgggg gaggcagcgg     2040

cgggggggga agccaggtgc agctggtcca atcaggcgcc gaggtcaaga aacctggagc     2100

gtcggtcaag gtctcctgca agactagccg ctacactttt accgaataca ccatccactg     2160

ggtcagacag gcgcccggtc agcgcctgga gtggatcggc gggatcaacc cgaataatgg     2220

aatcccgaac tacaatcaaa aattcaaagg ccgcgtgact atcaccgtgg atacttcagc     2280

ctcaactgct tacatggaac tgtcatcgct gagatcagag gacactgcgg tctactactg     2340

tgcgcgcaga agaatcgctt acggatacga cgaggggcac gcaatggact actggggaca     2400

gggaaccctg gtgaccgtgt cgtcaggcgg aggaggatcg gatgtgcagt tggtgcagtc     2460

gggcgccgaa gtgaaaaaac cgggggcctc agtgaaagtg tcctgcaagg cctccggata     2520

caccttcacc cgctacacta tgcactgggt caggcaggcg cccgggcagg gcctggagtg     2580

gatcgggtat atcaacccgt caaggggata cactaactac gccgactccg tgaagggaag     2640

attcactatc accactgaca aatcaacttc gacggcgtat atggaactgt catccttgag     2700

atcggaagat accgcgacct actactgtgc gcgctactac gatgaccatt actgcctcga     2760

ttactgggga cagggcacca cggtgaccgt ctcatcagga gaaggaactt caactggttc     2820

cggaggctcc ggcggctcag gcggcgctga cgacattgtg ctgacccaga gcccggcgac     2880

cctgtcactc tcgccggggg aaagggctac tctgtcatgc agagcgtcac aatcggtctc     2940

atacatgaac tggtaccagc agaaaccggg caaggctcca aagcggtgga tctacgatac     3000

ttcgaaggtg gcttcaggag tgccggctcg cttcagcgga tccggctcgg gaaccgatta     3060

cagcttgacc attaactcgc tggaggcgga ggatgcagcg acctactact gtcaacaatg     3120

gtcctcgaac ccactcactt ttgggggcgg gaccaaggtg gagattaag                 3169


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  124

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  125
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  125

Asp Lys Thr His Thr Ser 
1               5       


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ser is optional

<400>  126

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ser is optional

<400>  127

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  128
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ser is optional

<400>  128

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  129
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ser is optional

<400>  129

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  130
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ser is optional

<400>  130

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  131

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  133
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  134
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  135
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  136

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  137
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  137

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  138

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  139
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  139

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  140
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  140

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  141
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  141

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  142

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  143

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  144
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  144

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  145

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  146
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  146

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  147

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  148
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  148

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  149
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  149

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  150
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  150

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  151
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  151

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  152
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  152

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  153
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  153

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  154

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  155
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  155

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  156
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  156

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  157

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  158
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  158

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  159
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  159

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  160
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  160

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  161
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  161

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  162
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  162

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rigid linker

<400>  163

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  164
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rigid linker

<400>  164

Pro Pro Pro Pro 
1               


<210>  165

<400>  165
000

<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  166

Asp Lys Thr His Thr Cys Xaa Xaa 
1               5               


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  167

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  168
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  168

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  169
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  169

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  170
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequences

<400>  170

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  171
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  171

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  172

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  173
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  173

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  174

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  175

Asp Lys Thr His Thr Ser Xaa Xaa 
1               5               


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  176

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala 
1               5                   10      


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  177

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala 
1               5                   10      


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  178

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10      


<210>  179
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  179

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  180
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  180

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  181
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  181

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  182
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  182

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  183

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  184

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  185

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  186

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  187
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  187

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  188
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  188

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  189
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  189

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  190

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  191
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  191

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  192

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala 
        


<210>  193
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  193

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  194
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  194

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  195
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  195

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  196
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  196

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  197
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  197

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  198
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  198

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  199
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  199

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  200
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  200

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  201
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  201

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  202
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  202

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  203
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  203

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  204
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  204

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  205
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  205

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  206
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  206

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  207
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  207

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  208
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  208

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  209
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  209

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  210
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  210

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  211
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  211

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  212
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  212

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  213
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  213

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  214
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  214

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  215
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  215

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  216
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  216

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  217
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  217

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  218
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  218

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  219
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  219

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  220
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  220

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  221
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  221

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  222
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  222

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  223
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  223

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  224
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  224

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  225
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  225

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  226
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  226

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  227
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  227

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  228
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  228

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  229
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  229

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  230
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  230

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  231
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  231

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  232
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  232

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  233
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  233

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  234
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  234

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  235
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  235

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  236
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  236

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  237
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  237

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  238
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  238

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Cys Pro Ala 
            20                  25  


<210>  239
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  239

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  240
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  240

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Cys Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  241
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  241

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  242
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  242

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Ser Pro Ala 
            20                  25  


<210>  243
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  243

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Thr Ser Pro Pro Ser 
1               5                   10                  15      


Pro Ala Thr Ser Pro Pro Ser Pro Ala 
            20                  25  


<210>  244
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  244

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Ser Tyr 
            20                  25                  30  


<210>  245
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  245

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  246
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  246

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  247
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  247

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Ser Tyr 
            20                  25                  30  


<210>  248
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  248

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  249
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  249

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Ser Tyr 
            20                  25                  30  


<210>  250
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  250

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Ser Tyr 
            20                  25                  30  


<210>  251
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  251

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Ser Tyr 
            20                  25                  30      


<210>  252
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  252

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  253
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  253

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  254
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  254

Asp Lys Thr His Thr Cys Pro Pro Ser Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Ser Tyr 
            20                  25                  30      


<210>  255
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  255

Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Ser Tyr 
            20                  25                  30      


<210>  256
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  256

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  257
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  257

Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Ser Tyr 
            20                  25                  30      


<210>  258
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  258

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  259

Asp Lys Thr His Thr Cys Cys Val Glu Ser Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  260

Asp Lys Thr His Thr Cys Ser Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  261
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  261

Asp Lys Thr His Thr Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  262
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  262

Asp Lys Thr His Thr Cys Cys Val Glu Ser Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  263
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  263

Asp Lys Thr His Thr Cys Ser Val Glu Cys Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  264
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  264

Asp Lys Thr His Thr Ser Cys Val Glu Cys Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  265
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  265

Asp Lys Thr His Thr Cys Ser Val Glu Ser Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  266
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  266

Asp Lys Thr His Thr Ser Ser Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  267
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  267

Asp Lys Thr His Thr Cys Ser Val Glu Ser Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  268
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  268

Asp Lys Thr His Thr Ser Ser Val Glu Cys Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  269
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  269

Asp Lys Thr His Thr Ser Ser Val Glu Ser Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  270
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  270

Asp Lys Thr His Thr Ser Ser Val Glu Ser Pro Pro Ser Pro Ala 
1               5                   10                  15  


<210>  271
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  271

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  272
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  272

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Cys Pro Ala 
            20                  25      


<210>  273
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  273

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  274
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  274

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  275
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  275

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  276
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  276

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  277
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  277

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  278
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  278

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  279
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  279

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  280
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  280

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  281
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  281

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  282
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  282

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  283
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  283

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  284
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  284

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  285
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  285

Asp Lys Thr His Thr Ser Pro Arg Ser Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  286
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  286

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Cys Pro Ala 
            20                  25      


<210>  287
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  287

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Cys Pro Ala 
            20                  25      


<210>  288
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  288

Asp Lys Thr His Thr Ser Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  289
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  289

Asp Lys Thr His Thr Cys Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  290
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  290

Asp Lys Thr His Thr Ser Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Ser Pro Ala 
            20                  25      


<210>  291
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  291

Asp Lys Thr His Thr Ser Pro Arg Ser Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  292
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  292

Asp Lys Thr His Thr Ser Pro Arg Cys Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  293
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  293

Asp Lys Thr His Thr Ser Pro Arg Ser Pro Glu Pro Lys Ser Ser Asp 
1               5                   10                  15      


Thr Pro Pro Pro Ser Pro Arg Ser Pro Ala 
            20                  25      


<210>  294
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  294

Asp Lys Thr His Thr Cys Pro Ser Ser Pro Ala 
1               5                   10      


<210>  295
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  295

Asp Lys Thr His Thr Ser Pro Ser Cys Pro Ala 
1               5                   10      


<210>  296
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  296

Asp Lys Thr His Thr Ser Pro Ser Ser Pro Ala 
1               5                   10      


<210>  297
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  297

Gly Gly Gly Ser 
1               


