                         SEQUENCE LISTING

<110>  Universite Laval
       Doyon, Yannick
 
<120>  SELECTION SYSTEMS AND METHODS FOR GENOME EDITING

<130>  780/11229.373

<150>  US 62/381,292
<151>  2016-08-30

<150>  62/434,650
<151>  2016-12-15

<160>  487   

<170>  PatentIn version 3.5

<210>  1
<211>  3072
<212>  DNA
<213>  Homo sapiens

<400>  1
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctgct      360

acagaagagg aacctcaaaa cgataatctg tacctgggtg tggtgctatc agccgttgta      420

atcataactg gttgcttctc ctactatcaa gaagctaaaa gttcaaagat catggaatcc      480

ttcaaaaaca tggtccctca gcaagccctt gtgattcgaa atggtgagaa aatgagcata      540

aatgcggagg aagttgtggt tggggatctg gtggaagtaa aaggaggaga ccgaattcct      600

gctgacctca gaatcatatc tgcaaatggc tgcaaggtgg ataactcctc gctcactggt      660

gaatcagaac cccagactag gtctccagat ttcacaaatg aaaaccccct ggagacgagg      720

aacattgcct tcttttcaac caattgtgtt gaaggcaccg cacgtggtat tgttgtctac      780

actggggatc gcactgtgat gggaagaatt gccacacttg cttctgggct ggaaggaggc      840

cagaccccca ttgctgcaga aattgaacat tttatccaca tcatcacggg tgtggctgtg      900

ttcctgggtg tgtctttctt catcctttct ctcatccttg agtacacctg gcttgaggct      960

gtcatcttcc tcatcggtat catcgtagcc aatgtgccgg aaggtttgct ggccactgtc     1020

acggtctgtc tgacacttac tgccaaacgc atggcaagga aaaactgctt agtgaagaac     1080

ttagaagctg tggagacctt ggggtccacg tccaccatct gctctgataa aactggaact     1140

ctgactcaga accggatgac agtggcccac atgtggtttg acaatcaaat ccatgaagct     1200

gatacgacag agaatcagag tggtgtctct tttgacaaga cttcagctac ctggcttgct     1260

ctgtccagaa ttgcaggtct ttgtaacagg gcagtgtttc aggctaacca ggaaaaccta     1320

cctattctta agcgggcagt tgcaggagat gcctctgagt cagcactctt aaagtgcata     1380

gagctgtgct gtggttccgt gaaggagatg agagaaagat acgccaaaat cgtcgagata     1440

cccttcaact ccaccaacaa gtaccagttg tctattcata agaaccccaa cacatcggag     1500

ccccaacacc tgttggtgat gaagggcgcc ccagaaagga tcctagaccg ttgcagctct     1560

atcctcctcc acggcaagga gcagcccctg gatgaggagc tgaaagacgc ctttcagaac     1620

gcctatttgg agctgggggg cctcggagaa cgagtcctag gtttctgcca cctctttctg     1680

ccagatgaac agtttcctga agggttccag tttgacactg acgatgtgaa tttccctatc     1740

gataatctgt gctttgttgg gctcatctcc atgattgacc ctccacgggc ggccgttcct     1800

gatgccgtgg gcaaatgtcg aagtgctgga attaaggtca tcatggtcac aggagaccat     1860

ccaatcacag ctaaagctat tgccaaaggt gtgggcatca tctcagaagg caatgagacc     1920

gtggaagaca ttgctgcccg cctcaacatc ccagtcagcc aggtgaaccc cagggatgcc     1980

aaggcctgcg tagtacacgg cagtgatcta aaggacatga cctccgagca gctggatgac     2040

attttgaagt accacactga gatagtgttt gccaggacct cccctcagca gaagctcatc     2100

attgtggaag gctgccaaag acagggtgct atcgtggctg tgactggtga cggtgtgaat     2160

gactctccag ctttgaagaa agcagacatt ggggttgcta tggggattgc tggctcagat     2220

gtgtccaagc aagctgctga catgattctt ctggatgaca actttgcctc aattgtgact     2280

ggagtagagg aaggtcgtct gatctttgat aacttgaaga aatccattgc ttatacctta     2340

accagtaaca ttcccgagat caccccgttc ctgatattta ttattgcaaa cattccacta     2400

ccactgggga ctgtcaccat cctctgcatt gacttgggca ctgacatggt tcctgccatc     2460

tccctggctt atgagcaggc tgagagtgac atcatgaaga gacagcccag aaatcccaaa     2520

acagacaaac ttgtgaatga gcggctgatc agcatggcct atgggcagat tggaatgatc     2580

caggccctgg gaggcttctt tacttacttt gtgattctgg ctgagaacgg cttcctccca     2640

attcacctgt tgggcctccg agtggactgg gatgaccgct ggatcaacga tgtggaagac     2700

agctacgggc agcagtggac ctatgagcag aggaaaatcg tggagttcac ctgccacaca     2760

gccttcttcg tcagtatcgt ggtggtgcag tgggccgact tggtcatctg taagaccagg     2820

aggaattcgg tcttccagca ggggatgaag aacaagatct tgatatttgg cctctttgaa     2880

gagacagccc tggctgcttt cctttcctac tgccctggaa tgggtgttgc tcttaggatg     2940

tatcccctca aacctacctg gtggttctgt gccttcccct actctcttct catcttcgta     3000

tatgacgaag tcagaaaact catcatcagg cgacgccctg gcggctgggt ggagaaggaa     3060

acctactatt ag                                                         3072


<210>  2
<211>  404
<212>  DNA
<213>  Homo sapiens

<400>  2
cttccttaaa tccttattgc aaccgtccag ctaccaggta ggtatattgc cttgtaagtg       60

ctggtacagt ttgccttatt tatattccac tgcttctcag ggattaacat ctgctcgtgc      120

agctgagatc ctggcgcgag atggtcccaa cgccctcact ccccctccca ctactcctga      180

atggatcaag ttttgtcggc agctctttgg ggggttctca atgttactgt ggattggagc      240

gattctttgt ttcttggctt atagcatcca agctgctaca gaagaggaac ctcaaaacga      300

taatgtgagt tctgtaattc agcatatgga tttgtagtac acatcagata tcttctccgt      360

ctttgtctcc cacttcttct caattaccac tcattactta atgg                       404


<210>  3
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  4
<211>  1023
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  X is R or D

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  X is R or D

<400>  4

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Xaa Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Xaa Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  5
<211>  1023
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (119)..(126)
<223>  X is any amino acid

<400>  5

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  6
<211>  1023
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  X is any amino acid or is absent

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (338)..(338)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (345)..(345)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (793)..(793)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (800)..(800)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (804)..(804)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (870)..(870)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (887)..(887)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (989)..(989)
<223>  X is any amino acid

<400>  6

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Xaa Phe 
            100                 105                 110         


Leu Ala Xaa Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa 
        115                 120                 125             


Xaa Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Xaa Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Xaa Xaa Thr Val Thr Val Cys Leu Xaa Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Xaa Ile Ile Ala Asn Ile Pro Xaa 
785                 790                 795                 800 


Pro Leu Gly Xaa Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Xaa Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Xaa Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  7
<211>  3069
<212>  DNA
<213>  Homo sapiens

<400>  7
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctgct      360

aaagaggaac ctcaaaacga taatctgtac ctgggtgtgg tgctatcagc cgttgtaatc      420

ataactggtt gcttctccta ctatcaagaa gctaaaagtt caaagatcat ggaatccttc      480

aaaaacatgg tccctcagca agcccttgtg attcgaaatg gtgagaaaat gagcataaat      540

gcggaggaag ttgtggttgg ggatctggtg gaagtaaaag gaggagaccg aattcctgct      600

gacctcagaa tcatatctgc aaatggctgc aaggtggata actcctcgct cactggtgaa      660

tcagaacccc agactaggtc tccagatttc acaaatgaaa accccctgga gacgaggaac      720

attgccttct tttcaaccaa ttgtgttgaa ggcaccgcac gtggtattgt tgtctacact      780

ggggatcgca ctgtgatggg aagaattgcc acacttgctt ctgggctgga aggaggccag      840

acccccattg ctgcagaaat tgaacatttt atccacatca tcacgggtgt ggctgtgttc      900

ctgggtgtgt ctttcttcat cctttctctc atccttgagt acacctggct tgaggctgtc      960

atcttcctca tcggtatcat cgtagccaat gtgccggaag gtttgctggc cactgtcacg     1020

gtctgtctga cacttactgc caaacgcatg gcaaggaaaa actgcttagt gaagaactta     1080

gaagctgtgg agaccttggg gtccacgtcc accatctgct ctgataaaac tggaactctg     1140

actcagaacc ggatgacagt ggcccacatg tggtttgaca atcaaatcca tgaagctgat     1200

acgacagaga atcagagtgg tgtctctttt gacaagactt cagctacctg gcttgctctg     1260

tccagaattg caggtctttg taacagggca gtgtttcagg ctaaccagga aaacctacct     1320

attcttaagc gggcagttgc aggagatgcc tctgagtcag cactcttaaa gtgcatagag     1380

ctgtgctgtg gttccgtgaa ggagatgaga gaaagatacg ccaaaatcgt cgagataccc     1440

ttcaactcca ccaacaagta ccagttgtct attcataaga accccaacac atcggagccc     1500

caacacctgt tggtgatgaa gggcgcccca gaaaggatcc tagaccgttg cagctctatc     1560

ctcctccacg gcaaggagca gcccctggat gaggagctga aagacgcctt tcagaacgcc     1620

tatttggagc tggggggcct cggagaacga gtcctaggtt tctgccacct ctttctgcca     1680

gatgaacagt ttcctgaagg gttccagttt gacactgacg atgtgaattt ccctatcgat     1740

aatctgtgct ttgttgggct catctccatg attgaccctc cacgggcggc cgttcctgat     1800

gccgtgggca aatgtcgaag tgctggaatt aaggtcatca tggtcacagg agaccatcca     1860

atcacagcta aagctattgc caaaggtgtg ggcatcatct cagaaggcaa tgagaccgtg     1920

gaagacattg ctgcccgcct caacatccca gtcagccagg tgaaccccag ggatgccaag     1980

gcctgcgtag tacacggcag tgatctaaag gacatgacct ccgagcagct ggatgacatt     2040

ttgaagtacc acactgagat agtgtttgcc aggacctccc ctcagcagaa gctcatcatt     2100

gtggaaggct gccaaagaca gggtgctatc gtggctgtga ctggtgacgg tgtgaatgac     2160

tctccagctt tgaagaaagc agacattggg gttgctatgg ggattgctgg ctcagatgtg     2220

tccaagcaag ctgctgacat gattcttctg gatgacaact ttgcctcaat tgtgactgga     2280

gtagaggaag gtcgtctgat ctttgataac ttgaagaaat ccattgctta taccttaacc     2340

agtaacattc ccgagatcac cccgttcctg atatttatta ttgcaaacat tccactacca     2400

ctggggactg tcaccatcct ctgcattgac ttgggcactg acatggttcc tgccatctcc     2460

ctggcttatg agcaggctga gagtgacatc atgaagagac agcccagaaa tcccaaaaca     2520

gacaaacttg tgaatgagcg gctgatcagc atggcctatg ggcagattgg aatgatccag     2580

gccctgggag gcttctttac ttactttgtg attctggctg agaacggctt cctcccaatt     2640

cacctgttgg gcctccgagt ggactgggat gaccgctgga tcaacgatgt ggaagacagc     2700

tacgggcagc agtggaccta tgagcagagg aaaatcgtgg agttcacctg ccacacagcc     2760

ttcttcgtca gtatcgtggt ggtgcagtgg gccgacttgg tcatctgtaa gaccaggagg     2820

aattcggtct tccagcaggg gatgaagaac aagatcttga tatttggcct ctttgaagag     2880

acagccctgg ctgctttcct ttcctactgc cctggaatgg gtgttgctct taggatgtat     2940

cccctcaaac ctacctggtg gttctgtgcc ttcccctact ctcttctcat cttcgtatat     3000

gacgaagtca gaaaactcat catcaggcga cgccctggcg gctgggtgga gaaggaaacc     3060

tactattag                                                             3069


<210>  8
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Lys Glu Glu Pro Gln Asn Asp Asn 
        115                 120                 125             


Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys 
    130                 135                 140                 


Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe 
145                 150                 155                 160 


Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys 
                165                 170                 175     


Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val 
            180                 185                 190         


Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn 
        195                 200                 205             


Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln 
    210                 215                 220                 


Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn 
225                 230                 235                 240 


Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile 
                245                 250                 255     


Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu 
            260                 265                 270         


Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu 
        275                 280                 285             


His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser 
    290                 295                 300                 


Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val 
305                 310                 315                 320 


Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu 
                325                 330                 335     


Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg 
            340                 345                 350         


Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser 
        355                 360                 365             


Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg 
    370                 375                 380                 


Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp 
385                 390                 395                 400 


Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr 
                405                 410                 415     


Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe 
            420                 425                 430         


Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly 
        435                 440                 445             


Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly 
    450                 455                 460                 


Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro 
465                 470                 475                 480 


Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn 
                485                 490                 495     


Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg 
            500                 505                 510         


Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro 
        515                 520                 525             


Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu 
    530                 535                 540                 


Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro 
545                 550                 555                 560 


Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn 
                565                 570                 575     


Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp 
            580                 585                 590         


Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala 
        595                 600                 605             


Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys 
    610                 615                 620                 


Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val 
625                 630                 635                 640 


Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro 
                645                 650                 655     


Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met 
            660                 665                 670         


Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val 
        675                 680                 685             


Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys 
    690                 695                 700                 


Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp 
705                 710                 715                 720 


Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala 
                725                 730                 735     


Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp 
            740                 745                 750         


Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe 
        755                 760                 765             


Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro 
    770                 775                 780                 


Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro 
785                 790                 795                 800 


Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val 
                805                 810                 815     


Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys 
            820                 825                 830         


Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu 
        835                 840                 845             


Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly 
    850                 855                 860                 


Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile 
865                 870                 875                 880 


His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp 
                885                 890                 895     


Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile 
            900                 905                 910         


Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val 
        915                 920                 925             


Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe 
    930                 935                 940                 


Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu 
945                 950                 955                 960 


Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala 
                965                 970                 975     


Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro 
            980                 985                 990         


Tyr Ser Leu Leu Ile Phe Val Tyr  Asp Glu Val Arg Lys  Leu Ile Ile 
        995                 1000                 1005             


Arg Arg  Arg Pro Gly Gly Trp  Val Glu Lys Glu Thr  Tyr Tyr 
    1010                 1015                 1020         


<210>  9
<211>  3066
<212>  DNA
<213>  Homo sapiens

<400>  9
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctgct      360

acagaacctc aaaacgataa tctgtacctg ggtgtggtgc tatcagccgt tgtaatcata      420

actggttgct tctcctacta tcaagaagct aaaagttcaa agatcatgga atccttcaaa      480

aacatggtcc ctcagcaagc ccttgtgatt cgaaatggtg agaaaatgag cataaatgcg      540

gaggaagttg tggttgggga tctggtggaa gtaaaaggag gagaccgaat tcctgctgac      600

ctcagaatca tatctgcaaa tggctgcaag gtggataact cctcgctcac tggtgaatca      660

gaaccccaga ctaggtctcc agatttcaca aatgaaaacc ccctggagac gaggaacatt      720

gccttctttt caaccaattg tgttgaaggc accgcacgtg gtattgttgt ctacactggg      780

gatcgcactg tgatgggaag aattgccaca cttgcttctg ggctggaagg aggccagacc      840

cccattgctg cagaaattga acattttatc cacatcatca cgggtgtggc tgtgttcctg      900

ggtgtgtctt tcttcatcct ttctctcatc cttgagtaca cctggcttga ggctgtcatc      960

ttcctcatcg gtatcatcgt agccaatgtg ccggaaggtt tgctggccac tgtcacggtc     1020

tgtctgacac ttactgccaa acgcatggca aggaaaaact gcttagtgaa gaacttagaa     1080

gctgtggaga ccttggggtc cacgtccacc atctgctctg ataaaactgg aactctgact     1140

cagaaccgga tgacagtggc ccacatgtgg tttgacaatc aaatccatga agctgatacg     1200

acagagaatc agagtggtgt ctcttttgac aagacttcag ctacctggct tgctctgtcc     1260

agaattgcag gtctttgtaa cagggcagtg tttcaggcta accaggaaaa cctacctatt     1320

cttaagcggg cagttgcagg agatgcctct gagtcagcac tcttaaagtg catagagctg     1380

tgctgtggtt ccgtgaagga gatgagagaa agatacgcca aaatcgtcga gatacccttc     1440

aactccacca acaagtacca gttgtctatt cataagaacc ccaacacatc ggagccccaa     1500

cacctgttgg tgatgaaggg cgccccagaa aggatcctag accgttgcag ctctatcctc     1560

ctccacggca aggagcagcc cctggatgag gagctgaaag acgcctttca gaacgcctat     1620

ttggagctgg ggggcctcgg agaacgagtc ctaggtttct gccacctctt tctgccagat     1680

gaacagtttc ctgaagggtt ccagtttgac actgacgatg tgaatttccc tatcgataat     1740

ctgtgctttg ttgggctcat ctccatgatt gaccctccac gggcggccgt tcctgatgcc     1800

gtgggcaaat gtcgaagtgc tggaattaag gtcatcatgg tcacaggaga ccatccaatc     1860

acagctaaag ctattgccaa aggtgtgggc atcatctcag aaggcaatga gaccgtggaa     1920

gacattgctg cccgcctcaa catcccagtc agccaggtga accccaggga tgccaaggcc     1980

tgcgtagtac acggcagtga tctaaaggac atgacctccg agcagctgga tgacattttg     2040

aagtaccaca ctgagatagt gtttgccagg acctcccctc agcagaagct catcattgtg     2100

gaaggctgcc aaagacaggg tgctatcgtg gctgtgactg gtgacggtgt gaatgactct     2160

ccagctttga agaaagcaga cattggggtt gctatgggga ttgctggctc agatgtgtcc     2220

aagcaagctg ctgacatgat tcttctggat gacaactttg cctcaattgt gactggagta     2280

gaggaaggtc gtctgatctt tgataacttg aagaaatcca ttgcttatac cttaaccagt     2340

aacattcccg agatcacccc gttcctgata tttattattg caaacattcc actaccactg     2400

gggactgtca ccatcctctg cattgacttg ggcactgaca tggttcctgc catctccctg     2460

gcttatgagc aggctgagag tgacatcatg aagagacagc ccagaaatcc caaaacagac     2520

aaacttgtga atgagcggct gatcagcatg gcctatgggc agattggaat gatccaggcc     2580

ctgggaggct tctttactta ctttgtgatt ctggctgaga acggcttcct cccaattcac     2640

ctgttgggcc tccgagtgga ctgggatgac cgctggatca acgatgtgga agacagctac     2700

gggcagcagt ggacctatga gcagaggaaa atcgtggagt tcacctgcca cacagccttc     2760

ttcgtcagta tcgtggtggt gcagtgggcc gacttggtca tctgtaagac caggaggaat     2820

tcggtcttcc agcaggggat gaagaacaag atcttgatat ttggcctctt tgaagagaca     2880

gccctggctg ctttcctttc ctactgccct ggaatgggtg ttgctcttag gatgtatccc     2940

ctcaaaccta cctggtggtt ctgtgccttc ccctactctc ttctcatctt cgtatatgac     3000

gaagtcagaa aactcatcat caggcgacgc cctggcggct gggtggagaa ggaaacctac     3060

tattag                                                                3066


<210>  10
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Pro Gln Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met 
                165                 170                 175     


Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His 
        275                 280                 285             


Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp 
                405                 410                 415     


Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln 
            420                 425                 430         


Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser 
    450                 455                 460                 


Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr 
                485                 490                 495     


Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile 
            500                 505                 510         


Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu 
        515                 520                 525             


Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly 
    530                 535                 540                 


Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp 
545                 550                 555                 560 


Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe 
                565                 570                 575     


Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro 
            580                 585                 590         


Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly 
        595                 600                 605             


Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala 
    610                 615                 620                 


Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu 
625                 630                 635                 640 


Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg 
                645                 650                 655     


Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr 
            660                 665                 670         


Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe 
        675                 680                 685             


Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln 
    690                 695                 700                 


Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser 
705                 710                 715                 720 


Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly 
                725                 730                 735     


Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn 
            740                 745                 750         


Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp 
        755                 760                 765             


Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu 
    770                 775                 780                 


Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu 
785                 790                 795                 800 


Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro 
                805                 810                 815     


Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg 
            820                 825                 830         


Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile 
        835                 840                 845             


Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe 
    850                 855                 860                 


Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His 
865                 870                 875                 880 


Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val 
                885                 890                 895     


Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val 
            900                 905                 910         


Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val Gln 
        915                 920                 925             


Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln 
    930                 935                 940                 


Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr 
945                 950                 955                 960 


Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu 
                965                 970                 975     


Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr 
            980                 985                 990         


Ser Leu Leu Ile Phe Val Tyr Asp  Glu Val Arg Lys Leu  Ile Ile Arg 
        995                 1000                 1005             


Arg Arg  Pro Gly Gly Trp Val  Glu Lys Glu Thr Tyr  Tyr 
    1010                 1015                 1020     


<210>  11
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  11
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctgct      360

acagctcaaa acgataatct gtacctgggt gtggtgctat cagccgttgt aatcataact      420

ggttgcttct cctactatca agaagctaaa agttcaaaga tcatggaatc cttcaaaaac      480

atggtccctc agcaagccct tgtgattcga aatggtgaga aaatgagcat aaatgcggag      540

gaagttgtgg ttggggatct ggtggaagta aaaggaggag accgaattcc tgctgacctc      600

agaatcatat ctgcaaatgg ctgcaaggtg gataactcct cgctcactgg tgaatcagaa      660

ccccagacta ggtctccaga tttcacaaat gaaaaccccc tggagacgag gaacattgcc      720

ttcttttcaa ccaattgtgt tgaaggcacc gcacgtggta ttgttgtcta cactggggat      780

cgcactgtga tgggaagaat tgccacactt gcttctgggc tggaaggagg ccagaccccc      840

attgctgcag aaattgaaca ttttatccac atcatcacgg gtgtggctgt gttcctgggt      900

gtgtctttct tcatcctttc tctcatcctt gagtacacct ggcttgaggc tgtcatcttc      960

ctcatcggta tcatcgtagc caatgtgccg gaaggtttgc tggccactgt cacggtctgt     1020

ctgacactta ctgccaaacg catggcaagg aaaaactgct tagtgaagaa cttagaagct     1080

gtggagacct tggggtccac gtccaccatc tgctctgata aaactggaac tctgactcag     1140

aaccggatga cagtggccca catgtggttt gacaatcaaa tccatgaagc tgatacgaca     1200

gagaatcaga gtggtgtctc ttttgacaag acttcagcta cctggcttgc tctgtccaga     1260

attgcaggtc tttgtaacag ggcagtgttt caggctaacc aggaaaacct acctattctt     1320

aagcgggcag ttgcaggaga tgcctctgag tcagcactct taaagtgcat agagctgtgc     1380

tgtggttccg tgaaggagat gagagaaaga tacgccaaaa tcgtcgagat acccttcaac     1440

tccaccaaca agtaccagtt gtctattcat aagaacccca acacatcgga gccccaacac     1500

ctgttggtga tgaagggcgc cccagaaagg atcctagacc gttgcagctc tatcctcctc     1560

cacggcaagg agcagcccct ggatgaggag ctgaaagacg cctttcagaa cgcctatttg     1620

gagctggggg gcctcggaga acgagtccta ggtttctgcc acctctttct gccagatgaa     1680

cagtttcctg aagggttcca gtttgacact gacgatgtga atttccctat cgataatctg     1740

tgctttgttg ggctcatctc catgattgac cctccacggg cggccgttcc tgatgccgtg     1800

ggcaaatgtc gaagtgctgg aattaaggtc atcatggtca caggagacca tccaatcaca     1860

gctaaagcta ttgccaaagg tgtgggcatc atctcagaag gcaatgagac cgtggaagac     1920

attgctgccc gcctcaacat cccagtcagc caggtgaacc ccagggatgc caaggcctgc     1980

gtagtacacg gcagtgatct aaaggacatg acctccgagc agctggatga cattttgaag     2040

taccacactg agatagtgtt tgccaggacc tcccctcagc agaagctcat cattgtggaa     2100

ggctgccaaa gacagggtgc tatcgtggct gtgactggtg acggtgtgaa tgactctcca     2160

gctttgaaga aagcagacat tggggttgct atggggattg ctggctcaga tgtgtccaag     2220

caagctgctg acatgattct tctggatgac aactttgcct caattgtgac tggagtagag     2280

gaaggtcgtc tgatctttga taacttgaag aaatccattg cttatacctt aaccagtaac     2340

attcccgaga tcaccccgtt cctgatattt attattgcaa acattccact accactgggg     2400

actgtcacca tcctctgcat tgacttgggc actgacatgg ttcctgccat ctccctggct     2460

tatgagcagg ctgagagtga catcatgaag agacagccca gaaatcccaa aacagacaaa     2520

cttgtgaatg agcggctgat cagcatggcc tatgggcaga ttggaatgat ccaggccctg     2580

ggaggcttct ttacttactt tgtgattctg gctgagaacg gcttcctccc aattcacctg     2640

ttgggcctcc gagtggactg ggatgaccgc tggatcaacg atgtggaaga cagctacggg     2700

cagcagtgga cctatgagca gaggaaaatc gtggagttca cctgccacac agccttcttc     2760

gtcagtatcg tggtggtgca gtgggccgac ttggtcatct gtaagaccag gaggaattcg     2820

gtcttccagc aggggatgaa gaacaagatc ttgatatttg gcctctttga agagacagcc     2880

ctggctgctt tcctttccta ctgccctgga atgggtgttg ctcttaggat gtatcccctc     2940

aaacctacct ggtggttctg tgccttcccc tactctcttc tcatcttcgt atatgacgaa     3000

gtcagaaaac tcatcatcag gcgacgccct ggcggctggg tggagaagga aacctactat     3060

tag                                                                   3063


<210>  12
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Ala Gln Asn Asp Asn Leu Tyr 
        115                 120                 125             


Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe Ser 
    130                 135                 140                 


Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn 
145                 150                 155                 160 


Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met Ser 
                165                 170                 175     


Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys Gly 
            180                 185                 190         


Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly Cys 
        195                 200                 205             


Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg 
    210                 215                 220                 


Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile Ala 
225                 230                 235                 240 


Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Val 
                245                 250                 255     


Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser 
            260                 265                 270         


Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe 
        275                 280                 285             


Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe 
    290                 295                 300                 


Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile Phe 
305                 310                 315                 320 


Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr 
                325                 330                 335     


Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn 
            340                 345                 350         


Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser 
        355                 360                 365             


Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr 
    370                 375                 380                 


Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr 
385                 390                 395                 400 


Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp Leu 
                405                 410                 415     


Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln Ala 
            420                 425                 430         


Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp Ala 
        435                 440                 445             


Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser Val 
    450                 455                 460                 


Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe Asn 
465                 470                 475                 480 


Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr Ser 
                485                 490                 495     


Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu Asp 
        515                 520                 525             


Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp Glu 
545                 550                 555                 560 


Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe Pro 
                565                 570                 575     


Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His Leu 
865                 870                 875                 880 


Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Val Tyr Asp Glu  Val Arg Lys Leu Ile  Ile Arg Arg 
        995                 1000                 1005             


Arg Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  13
<211>  3060
<212>  DNA
<213>  Homo sapiens

<400>  13
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagaggaa      360

cctcaaaacg ataatctgta cctgggtgtg gtgctatcag ccgttgtaat cataactggt      420

tgcttctcct actatcaaga agctaaaagt tcaaagatca tggaatcctt caaaaacatg      480

gtccctcagc aagcccttgt gattcgaaat ggtgagaaaa tgagcataaa tgcggaggaa      540

gttgtggttg gggatctggt ggaagtaaaa ggaggagacc gaattcctgc tgacctcaga      600

atcatatctg caaatggctg caaggtggat aactcctcgc tcactggtga atcagaaccc      660

cagactaggt ctccagattt cacaaatgaa aaccccctgg agacgaggaa cattgccttc      720

ttttcaacca attgtgttga aggcaccgca cgtggtattg ttgtctacac tggggatcgc      780

actgtgatgg gaagaattgc cacacttgct tctgggctgg aaggaggcca gacccccatt      840

gctgcagaaa ttgaacattt tatccacatc atcacgggtg tggctgtgtt cctgggtgtg      900

tctttcttca tcctttctct catccttgag tacacctggc ttgaggctgt catcttcctc      960

atcggtatca tcgtagccaa tgtgccggaa ggtttgctgg ccactgtcac ggtctgtctg     1020

acacttactg ccaaacgcat ggcaaggaaa aactgcttag tgaagaactt agaagctgtg     1080

gagaccttgg ggtccacgtc caccatctgc tctgataaaa ctggaactct gactcagaac     1140

cggatgacag tggcccacat gtggtttgac aatcaaatcc atgaagctga tacgacagag     1200

aatcagagtg gtgtctcttt tgacaagact tcagctacct ggcttgctct gtccagaatt     1260

gcaggtcttt gtaacagggc agtgtttcag gctaaccagg aaaacctacc tattcttaag     1320

cgggcagttg caggagatgc ctctgagtca gcactcttaa agtgcataga gctgtgctgt     1380

ggttccgtga aggagatgag agaaagatac gccaaaatcg tcgagatacc cttcaactcc     1440

accaacaagt accagttgtc tattcataag aaccccaaca catcggagcc ccaacacctg     1500

ttggtgatga agggcgcccc agaaaggatc ctagaccgtt gcagctctat cctcctccac     1560

ggcaaggagc agcccctgga tgaggagctg aaagacgcct ttcagaacgc ctatttggag     1620

ctggggggcc tcggagaacg agtcctaggt ttctgccacc tctttctgcc agatgaacag     1680

tttcctgaag ggttccagtt tgacactgac gatgtgaatt tccctatcga taatctgtgc     1740

tttgttgggc tcatctccat gattgaccct ccacgggcgg ccgttcctga tgccgtgggc     1800

aaatgtcgaa gtgctggaat taaggtcatc atggtcacag gagaccatcc aatcacagct     1860

aaagctattg ccaaaggtgt gggcatcatc tcagaaggca atgagaccgt ggaagacatt     1920

gctgcccgcc tcaacatccc agtcagccag gtgaacccca gggatgccaa ggcctgcgta     1980

gtacacggca gtgatctaaa ggacatgacc tccgagcagc tggatgacat tttgaagtac     2040

cacactgaga tagtgtttgc caggacctcc cctcagcaga agctcatcat tgtggaaggc     2100

tgccaaagac agggtgctat cgtggctgtg actggtgacg gtgtgaatga ctctccagct     2160

ttgaagaaag cagacattgg ggttgctatg gggattgctg gctcagatgt gtccaagcaa     2220

gctgctgaca tgattcttct ggatgacaac tttgcctcaa ttgtgactgg agtagaggaa     2280

ggtcgtctga tctttgataa cttgaagaaa tccattgctt ataccttaac cagtaacatt     2340

cccgagatca ccccgttcct gatatttatt attgcaaaca ttccactacc actggggact     2400

gtcaccatcc tctgcattga cttgggcact gacatggttc ctgccatctc cctggcttat     2460

gagcaggctg agagtgacat catgaagaga cagcccagaa atcccaaaac agacaaactt     2520

gtgaatgagc ggctgatcag catggcctat gggcagattg gaatgatcca ggccctggga     2580

ggcttcttta cttactttgt gattctggct gagaacggct tcctcccaat tcacctgttg     2640

ggcctccgag tggactggga tgaccgctgg atcaacgatg tggaagacag ctacgggcag     2700

cagtggacct atgagcagag gaaaatcgtg gagttcacct gccacacagc cttcttcgtc     2760

agtatcgtgg tggtgcagtg ggccgacttg gtcatctgta agaccaggag gaattcggtc     2820

ttccagcagg ggatgaagaa caagatcttg atatttggcc tctttgaaga gacagccctg     2880

gctgctttcc tttcctactg ccctggaatg ggtgttgctc ttaggatgta tcccctcaaa     2940

cctacctggt ggttctgtgc cttcccctac tctcttctca tcttcgtata tgacgaagtc     3000

agaaaactca tcatcaggcg acgccctggc ggctgggtgg agaaggaaac ctactattag     3060


<210>  14
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Glu Glu Pro Gln Asn Asp Asn Leu Tyr Leu 
        115                 120                 125             


Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr 
    130                 135                 140                 


Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met 
145                 150                 155                 160 


Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met Ser Ile 
                165                 170                 175     


Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly 
            180                 185                 190         


Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly Cys Lys 
        195                 200                 205             


Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser 
    210                 215                 220                 


Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile Ala Phe 
225                 230                 235                 240 


Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Val Tyr 
                245                 250                 255     


Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly 
            260                 265                 270         


Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile 
        275                 280                 285             


His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile 
    290                 295                 300                 


Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu 
305                 310                 315                 320 


Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val 
                325                 330                 335     


Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys 
            340                 345                 350         


Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr 
        355                 360                 365             


Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val 
    370                 375                 380                 


Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu 
385                 390                 395                 400 


Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp Leu Ala 
                405                 410                 415     


Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln Ala Asn 
            420                 425                 430         


Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp Ala Ser 
        435                 440                 445             


Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser Val Lys 
    450                 455                 460                 


Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe Asn Ser 
465                 470                 475                 480 


Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr Ser Glu 
                485                 490                 495     


Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp 
            500                 505                 510         


Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu Asp Glu 
        515                 520                 525             


Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu 
    530                 535                 540                 


Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp Glu Gln 
545                 550                 555                 560 


Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe Pro Ile 
                565                 570                 575     


Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro Arg 
            580                 585                 590         


Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys 
        595                 600                 605             


Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala 
    610                 615                 620                 


Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile 
625                 630                 635                 640 


Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala 
                645                 650                 655     


Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu 
            660                 665                 670         


Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe Ala Arg 
        675                 680                 685             


Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln 
    690                 695                 700                 


Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala 
705                 710                 715                 720 


Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp 
                725                 730                 735     


Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala 
            740                 745                 750         


Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu 
        755                 760                 765             


Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr 
    770                 775                 780                 


Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr 
785                 790                 795                 800 


Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile 
                805                 810                 815     


Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg Gln Pro 
            820                 825                 830         


Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met 
        835                 840                 845             


Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr 
    850                 855                 860                 


Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His Leu Leu 
865                 870                 875                 880 


Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val Glu Asp 
                885                 890                 895     


Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val Glu Phe 
            900                 905                 910         


Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala 
        915                 920                 925             


Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly 
    930                 935                 940                 


Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu 
945                 950                 955                 960 


Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met 
                965                 970                 975     


Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu 
            980                 985                 990         


Leu Ile Phe Val Tyr Asp Glu Val  Arg Lys Leu Ile Ile  Arg Arg Arg 
        995                 1000                 1005             


Pro Gly  Gly Trp Val Glu Lys  Glu Thr Tyr Tyr 
    1010                 1015                 


<210>  15
<211>  3069
<212>  DNA
<213>  Homo sapiens

<400>  15
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctaca      360

gaagaggaac ctcaaaacga taatctgtac ctgggtgtgg tgctatcagc cgttgtaatc      420

ataactggtt gcttctccta ctatcaagaa gctaaaagtt caaagatcat ggaatccttc      480

aaaaacatgg tccctcagca agcccttgtg attcgaaatg gtgagaaaat gagcataaat      540

gcggaggaag ttgtggttgg ggatctggtg gaagtaaaag gaggagaccg aattcctgct      600

gacctcagaa tcatatctgc aaatggctgc aaggtggata actcctcgct cactggtgaa      660

tcagaacccc agactaggtc tccagatttc acaaatgaaa accccctgga gacgaggaac      720

attgccttct tttcaaccaa ttgtgttgaa ggcaccgcac gtggtattgt tgtctacact      780

ggggatcgca ctgtgatggg aagaattgcc acacttgctt ctgggctgga aggaggccag      840

acccccattg ctgcagaaat tgaacatttt atccacatca tcacgggtgt ggctgtgttc      900

ctgggtgtgt ctttcttcat cctttctctc atccttgagt acacctggct tgaggctgtc      960

atcttcctca tcggtatcat cgtagccaat gtgccggaag gtttgctggc cactgtcacg     1020

gtctgtctga cacttactgc caaacgcatg gcaaggaaaa actgcttagt gaagaactta     1080

gaagctgtgg agaccttggg gtccacgtcc accatctgct ctgataaaac tggaactctg     1140

actcagaacc ggatgacagt ggcccacatg tggtttgaca atcaaatcca tgaagctgat     1200

acgacagaga atcagagtgg tgtctctttt gacaagactt cagctacctg gcttgctctg     1260

tccagaattg caggtctttg taacagggca gtgtttcagg ctaaccagga aaacctacct     1320

attcttaagc gggcagttgc aggagatgcc tctgagtcag cactcttaaa gtgcatagag     1380

ctgtgctgtg gttccgtgaa ggagatgaga gaaagatacg ccaaaatcgt cgagataccc     1440

ttcaactcca ccaacaagta ccagttgtct attcataaga accccaacac atcggagccc     1500

caacacctgt tggtgatgaa gggcgcccca gaaaggatcc tagaccgttg cagctctatc     1560

ctcctccacg gcaaggagca gcccctggat gaggagctga aagacgcctt tcagaacgcc     1620

tatttggagc tggggggcct cggagaacga gtcctaggtt tctgccacct ctttctgcca     1680

gatgaacagt ttcctgaagg gttccagttt gacactgacg atgtgaattt ccctatcgat     1740

aatctgtgct ttgttgggct catctccatg attgaccctc cacgggcggc cgttcctgat     1800

gccgtgggca aatgtcgaag tgctggaatt aaggtcatca tggtcacagg agaccatcca     1860

atcacagcta aagctattgc caaaggtgtg ggcatcatct cagaaggcaa tgagaccgtg     1920

gaagacattg ctgcccgcct caacatccca gtcagccagg tgaaccccag ggatgccaag     1980

gcctgcgtag tacacggcag tgatctaaag gacatgacct ccgagcagct ggatgacatt     2040

ttgaagtacc acactgagat agtgtttgcc aggacctccc ctcagcagaa gctcatcatt     2100

gtggaaggct gccaaagaca gggtgctatc gtggctgtga ctggtgacgg tgtgaatgac     2160

tctccagctt tgaagaaagc agacattggg gttgctatgg ggattgctgg ctcagatgtg     2220

tccaagcaag ctgctgacat gattcttctg gatgacaact ttgcctcaat tgtgactgga     2280

gtagaggaag gtcgtctgat ctttgataac ttgaagaaat ccattgctta taccttaacc     2340

agtaacattc ccgagatcac cccgttcctg atatttatta ttgcaaacat tccactacca     2400

ctggggactg tcaccatcct ctgcattgac ttgggcactg acatggttcc tgccatctcc     2460

ctggcttatg agcaggctga gagtgacatc atgaagagac agcccagaaa tcccaaaaca     2520

gacaaacttg tgaatgagcg gctgatcagc atggcctatg ggcagattgg aatgatccag     2580

gccctgggag gcttctttac ttactttgtg attctggctg agaacggctt cctcccaatt     2640

cacctgttgg gcctccgagt ggactgggat gaccgctgga tcaacgatgt ggaagacagc     2700

tacgggcagc agtggaccta tgagcagagg aaaatcgtgg agttcacctg ccacacagcc     2760

ttcttcgtca gtatcgtggt ggtgcagtgg gccgacttgg tcatctgtaa gaccaggagg     2820

aattcggtct tccagcaggg gatgaagaac aagatcttga tatttggcct ctttgaagag     2880

acagccctgg ctgctttcct ttcctactgc cctggaatgg gtgttgctct taggatgtat     2940

cccctcaaac ctacctggtg gttctgtgcc ttcccctact ctcttctcat cttcgtatat     3000

gacgaagtca gaaaactcat catcaggcga cgccctggcg gctgggtgga gaaggaaacc     3060

tactattag                                                             3069


<210>  16
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Thr Glu Glu Glu Pro Gln Asn Asp Asn 
        115                 120                 125             


Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys 
    130                 135                 140                 


Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe 
145                 150                 155                 160 


Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys 
                165                 170                 175     


Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val 
            180                 185                 190         


Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn 
        195                 200                 205             


Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln 
    210                 215                 220                 


Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn 
225                 230                 235                 240 


Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile 
                245                 250                 255     


Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu 
            260                 265                 270         


Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu 
        275                 280                 285             


His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser 
    290                 295                 300                 


Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val 
305                 310                 315                 320 


Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu 
                325                 330                 335     


Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg 
            340                 345                 350         


Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser 
        355                 360                 365             


Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg 
    370                 375                 380                 


Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp 
385                 390                 395                 400 


Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr 
                405                 410                 415     


Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe 
            420                 425                 430         


Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly 
        435                 440                 445             


Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly 
    450                 455                 460                 


Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro 
465                 470                 475                 480 


Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn 
                485                 490                 495     


Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg 
            500                 505                 510         


Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro 
        515                 520                 525             


Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu 
    530                 535                 540                 


Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro 
545                 550                 555                 560 


Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn 
                565                 570                 575     


Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp 
            580                 585                 590         


Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala 
        595                 600                 605             


Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys 
    610                 615                 620                 


Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val 
625                 630                 635                 640 


Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro 
                645                 650                 655     


Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met 
            660                 665                 670         


Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val 
        675                 680                 685             


Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys 
    690                 695                 700                 


Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp 
705                 710                 715                 720 


Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala 
                725                 730                 735     


Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp 
            740                 745                 750         


Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe 
        755                 760                 765             


Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro 
    770                 775                 780                 


Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro 
785                 790                 795                 800 


Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val 
                805                 810                 815     


Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys 
            820                 825                 830         


Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu 
        835                 840                 845             


Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly 
    850                 855                 860                 


Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile 
865                 870                 875                 880 


His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp 
                885                 890                 895     


Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile 
            900                 905                 910         


Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val 
        915                 920                 925             


Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe 
    930                 935                 940                 


Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu 
945                 950                 955                 960 


Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala 
                965                 970                 975     


Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro 
            980                 985                 990         


Tyr Ser Leu Leu Ile Phe Val Tyr  Asp Glu Val Arg Lys  Leu Ile Ile 
        995                 1000                 1005             


Arg Arg  Arg Pro Gly Gly Trp  Val Glu Lys Glu Thr  Tyr Tyr 
    1010                 1015                 1020         


<210>  17
<211>  3057
<212>  DNA
<213>  Homo sapiens

<400>  17
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaggaacct      360

caaaacgata atctgtacct gggtgtggtg ctatcagccg ttgtaatcat aactggttgc      420

ttctcctact atcaagaagc taaaagttca aagatcatgg aatccttcaa aaacatggtc      480

cctcagcaag cccttgtgat tcgaaatggt gagaaaatga gcataaatgc ggaggaagtt      540

gtggttgggg atctggtgga agtaaaagga ggagaccgaa ttcctgctga cctcagaatc      600

atatctgcaa atggctgcaa ggtggataac tcctcgctca ctggtgaatc agaaccccag      660

actaggtctc cagatttcac aaatgaaaac cccctggaga cgaggaacat tgccttcttt      720

tcaaccaatt gtgttgaagg caccgcacgt ggtattgttg tctacactgg ggatcgcact      780

gtgatgggaa gaattgccac acttgcttct gggctggaag gaggccagac ccccattgct      840

gcagaaattg aacattttat ccacatcatc acgggtgtgg ctgtgttcct gggtgtgtct      900

ttcttcatcc tttctctcat ccttgagtac acctggcttg aggctgtcat cttcctcatc      960

ggtatcatcg tagccaatgt gccggaaggt ttgctggcca ctgtcacggt ctgtctgaca     1020

cttactgcca aacgcatggc aaggaaaaac tgcttagtga agaacttaga agctgtggag     1080

accttggggt ccacgtccac catctgctct gataaaactg gaactctgac tcagaaccgg     1140

atgacagtgg cccacatgtg gtttgacaat caaatccatg aagctgatac gacagagaat     1200

cagagtggtg tctcttttga caagacttca gctacctggc ttgctctgtc cagaattgca     1260

ggtctttgta acagggcagt gtttcaggct aaccaggaaa acctacctat tcttaagcgg     1320

gcagttgcag gagatgcctc tgagtcagca ctcttaaagt gcatagagct gtgctgtggt     1380

tccgtgaagg agatgagaga aagatacgcc aaaatcgtcg agataccctt caactccacc     1440

aacaagtacc agttgtctat tcataagaac cccaacacat cggagcccca acacctgttg     1500

gtgatgaagg gcgccccaga aaggatccta gaccgttgca gctctatcct cctccacggc     1560

aaggagcagc ccctggatga ggagctgaaa gacgcctttc agaacgccta tttggagctg     1620

gggggcctcg gagaacgagt cctaggtttc tgccacctct ttctgccaga tgaacagttt     1680

cctgaagggt tccagtttga cactgacgat gtgaatttcc ctatcgataa tctgtgcttt     1740

gttgggctca tctccatgat tgaccctcca cgggcggccg ttcctgatgc cgtgggcaaa     1800

tgtcgaagtg ctggaattaa ggtcatcatg gtcacaggag accatccaat cacagctaaa     1860

gctattgcca aaggtgtggg catcatctca gaaggcaatg agaccgtgga agacattgct     1920

gcccgcctca acatcccagt cagccaggtg aaccccaggg atgccaaggc ctgcgtagta     1980

cacggcagtg atctaaagga catgacctcc gagcagctgg atgacatttt gaagtaccac     2040

actgagatag tgtttgccag gacctcccct cagcagaagc tcatcattgt ggaaggctgc     2100

caaagacagg gtgctatcgt ggctgtgact ggtgacggtg tgaatgactc tccagctttg     2160

aagaaagcag acattggggt tgctatgggg attgctggct cagatgtgtc caagcaagct     2220

gctgacatga ttcttctgga tgacaacttt gcctcaattg tgactggagt agaggaaggt     2280

cgtctgatct ttgataactt gaagaaatcc attgcttata ccttaaccag taacattccc     2340

gagatcaccc cgttcctgat atttattatt gcaaacattc cactaccact ggggactgtc     2400

accatcctct gcattgactt gggcactgac atggttcctg ccatctccct ggcttatgag     2460

caggctgaga gtgacatcat gaagagacag cccagaaatc ccaaaacaga caaacttgtg     2520

aatgagcggc tgatcagcat ggcctatggg cagattggaa tgatccaggc cctgggaggc     2580

ttctttactt actttgtgat tctggctgag aacggcttcc tcccaattca cctgttgggc     2640

ctccgagtgg actgggatga ccgctggatc aacgatgtgg aagacagcta cgggcagcag     2700

tggacctatg agcagaggaa aatcgtggag ttcacctgcc acacagcctt cttcgtcagt     2760

atcgtggtgg tgcagtgggc cgacttggtc atctgtaaga ccaggaggaa ttcggtcttc     2820

cagcagggga tgaagaacaa gatcttgata tttggcctct ttgaagagac agccctggct     2880

gctttccttt cctactgccc tggaatgggt gttgctctta ggatgtatcc cctcaaacct     2940

acctggtggt tctgtgcctt cccctactct cttctcatct tcgtatatga cgaagtcaga     3000

aaactcatca tcaggcgacg ccctggcggc tgggtggaga aggaaaccta ctattag        3057


<210>  18
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Glu Pro Gln Asn Asp Asn Leu Tyr Leu Gly 
        115                 120                 125             


Val Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr 
    130                 135                 140                 


Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val 
145                 150                 155                 160 


Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met Ser Ile Asn 
                165                 170                 175     


Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly Asp 
            180                 185                 190         


Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly Cys Lys Val 
        195                 200                 205             


Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro 
    210                 215                 220                 


Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe 
225                 230                 235                 240 


Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Val Tyr Thr 
                245                 250                 255     


Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu 
            260                 265                 270         


Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His 
        275                 280                 285             


Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu 
    290                 295                 300                 


Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile 
305                 310                 315                 320 


Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr 
                325                 330                 335     


Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu 
            340                 345                 350         


Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile 
        355                 360                 365             


Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala 
    370                 375                 380                 


His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asn 
385                 390                 395                 400 


Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp Leu Ala Leu 
                405                 410                 415     


Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln Ala Asn Gln 
            420                 425                 430         


Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp Ala Ser Glu 
        435                 440                 445             


Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser Val Lys Glu 
    450                 455                 460                 


Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe Asn Ser Thr 
465                 470                 475                 480 


Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr Ser Glu Pro 
                485                 490                 495     


Gln His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg 
            500                 505                 510         


Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu Asp Glu Glu 
        515                 520                 525             


Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly 
    530                 535                 540                 


Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp Glu Gln Phe 
545                 550                 555                 560 


Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe Pro Ile Asp 
                565                 570                 575     


Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala 
            580                 585                 590         


Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val 
        595                 600                 605             


Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys 
    610                 615                 620                 


Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala 
625                 630                 635                 640 


Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys 
                645                 650                 655     


Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu Gln 
            660                 665                 670         


Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe Ala Arg Thr 
        675                 680                 685             


Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly 
    690                 695                 700                 


Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu 
705                 710                 715                 720 


Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val 
                725                 730                 735     


Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser 
            740                 745                 750         


Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys 
        755                 760                 765             


Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro 
    770                 775                 780                 


Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr Val 
785                 790                 795                 800 


Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser 
                805                 810                 815     


Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg 
            820                 825                 830         


Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala 
        835                 840                 845             


Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr Tyr 
    850                 855                 860                 


Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His Leu Leu Gly 
865                 870                 875                 880 


Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val Glu Asp Ser 
                885                 890                 895     


Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val Glu Phe Thr 
            900                 905                 910         


Cys His Thr Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp 
        915                 920                 925             


Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met 
    930                 935                 940                 


Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala 
945                 950                 955                 960 


Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met Tyr 
                965                 970                 975     


Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu Leu 
            980                 985                 990         


Ile Phe Val Tyr Asp Glu Val Arg  Lys Leu Ile Ile Arg  Arg Arg Pro 
        995                 1000                 1005             


Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015             


<210>  19
<211>  3054
<212>  DNA
<213>  Homo sapiens

<400>  19
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaacctcaa      360

aacgataatc tgtacctggg tgtggtgcta tcagccgttg taatcataac tggttgcttc      420

tcctactatc aagaagctaa aagttcaaag atcatggaat ccttcaaaaa catggtccct      480

cagcaagccc ttgtgattcg aaatggtgag aaaatgagca taaatgcgga ggaagttgtg      540

gttggggatc tggtggaagt aaaaggagga gaccgaattc ctgctgacct cagaatcata      600

tctgcaaatg gctgcaaggt ggataactcc tcgctcactg gtgaatcaga accccagact      660

aggtctccag atttcacaaa tgaaaacccc ctggagacga ggaacattgc cttcttttca      720

accaattgtg ttgaaggcac cgcacgtggt attgttgtct acactgggga tcgcactgtg      780

atgggaagaa ttgccacact tgcttctggg ctggaaggag gccagacccc cattgctgca      840

gaaattgaac attttatcca catcatcacg ggtgtggctg tgttcctggg tgtgtctttc      900

ttcatccttt ctctcatcct tgagtacacc tggcttgagg ctgtcatctt cctcatcggt      960

atcatcgtag ccaatgtgcc ggaaggtttg ctggccactg tcacggtctg tctgacactt     1020

actgccaaac gcatggcaag gaaaaactgc ttagtgaaga acttagaagc tgtggagacc     1080

ttggggtcca cgtccaccat ctgctctgat aaaactggaa ctctgactca gaaccggatg     1140

acagtggccc acatgtggtt tgacaatcaa atccatgaag ctgatacgac agagaatcag     1200

agtggtgtct cttttgacaa gacttcagct acctggcttg ctctgtccag aattgcaggt     1260

ctttgtaaca gggcagtgtt tcaggctaac caggaaaacc tacctattct taagcgggca     1320

gttgcaggag atgcctctga gtcagcactc ttaaagtgca tagagctgtg ctgtggttcc     1380

gtgaaggaga tgagagaaag atacgccaaa atcgtcgaga tacccttcaa ctccaccaac     1440

aagtaccagt tgtctattca taagaacccc aacacatcgg agccccaaca cctgttggtg     1500

atgaagggcg ccccagaaag gatcctagac cgttgcagct ctatcctcct ccacggcaag     1560

gagcagcccc tggatgagga gctgaaagac gcctttcaga acgcctattt ggagctgggg     1620

ggcctcggag aacgagtcct aggtttctgc cacctctttc tgccagatga acagtttcct     1680

gaagggttcc agtttgacac tgacgatgtg aatttcccta tcgataatct gtgctttgtt     1740

gggctcatct ccatgattga ccctccacgg gcggccgttc ctgatgccgt gggcaaatgt     1800

cgaagtgctg gaattaaggt catcatggtc acaggagacc atccaatcac agctaaagct     1860

attgccaaag gtgtgggcat catctcagaa ggcaatgaga ccgtggaaga cattgctgcc     1920

cgcctcaaca tcccagtcag ccaggtgaac cccagggatg ccaaggcctg cgtagtacac     1980

ggcagtgatc taaaggacat gacctccgag cagctggatg acattttgaa gtaccacact     2040

gagatagtgt ttgccaggac ctcccctcag cagaagctca tcattgtgga aggctgccaa     2100

agacagggtg ctatcgtggc tgtgactggt gacggtgtga atgactctcc agctttgaag     2160

aaagcagaca ttggggttgc tatggggatt gctggctcag atgtgtccaa gcaagctgct     2220

gacatgattc ttctggatga caactttgcc tcaattgtga ctggagtaga ggaaggtcgt     2280

ctgatctttg ataacttgaa gaaatccatt gcttatacct taaccagtaa cattcccgag     2340

atcaccccgt tcctgatatt tattattgca aacattccac taccactggg gactgtcacc     2400

atcctctgca ttgacttggg cactgacatg gttcctgcca tctccctggc ttatgagcag     2460

gctgagagtg acatcatgaa gagacagccc agaaatccca aaacagacaa acttgtgaat     2520

gagcggctga tcagcatggc ctatgggcag attggaatga tccaggccct gggaggcttc     2580

tttacttact ttgtgattct ggctgagaac ggcttcctcc caattcacct gttgggcctc     2640

cgagtggact gggatgaccg ctggatcaac gatgtggaag acagctacgg gcagcagtgg     2700

acctatgagc agaggaaaat cgtggagttc acctgccaca cagccttctt cgtcagtatc     2760

gtggtggtgc agtgggccga cttggtcatc tgtaagacca ggaggaattc ggtcttccag     2820

caggggatga agaacaagat cttgatattt ggcctctttg aagagacagc cctggctgct     2880

ttcctttcct actgccctgg aatgggtgtt gctcttagga tgtatcccct caaacctacc     2940

tggtggttct gtgccttccc ctactctctt ctcatcttcg tatatgacga agtcagaaaa     3000

ctcatcatca ggcgacgccc tggcggctgg gtggagaagg aaacctacta ttag           3054


<210>  20
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Pro Gln Asn Asp Asn Leu Tyr Leu Gly Val 
        115                 120                 125             


Val Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln 
    130                 135                 140                 


Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro 
145                 150                 155                 160 


Gln Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met Ser Ile Asn Ala 
                165                 170                 175     


Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly Asp Arg 
            180                 185                 190         


Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly Cys Lys Val Asp 
        195                 200                 205             


Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp 
    210                 215                 220                 


Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe Ser 
225                 230                 235                 240 


Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Val Tyr Thr Gly 
                245                 250                 255     


Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu 
            260                 265                 270         


Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Ile 
        275                 280                 285             


Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser 
    290                 295                 300                 


Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly 
305                 310                 315                 320 


Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val 
                325                 330                 335     


Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val 
            340                 345                 350         


Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys 
        355                 360                 365             


Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His 
    370                 375                 380                 


Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asn Gln 
385                 390                 395                 400 


Ser Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp Leu Ala Leu Ser 
                405                 410                 415     


Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln Ala Asn Gln Glu 
            420                 425                 430         


Asn Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp Ala Ser Glu Ser 
        435                 440                 445             


Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser Val Lys Glu Met 
    450                 455                 460                 


Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe Asn Ser Thr Asn 
465                 470                 475                 480 


Lys Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr Ser Glu Pro Gln 
                485                 490                 495     


His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys 
            500                 505                 510         


Ser Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu Asp Glu Glu Leu 
        515                 520                 525             


Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu 
    530                 535                 540                 


Arg Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp Glu Gln Phe Pro 
545                 550                 555                 560 


Glu Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe Pro Ile Asp Asn 
                565                 570                 575     


Leu Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala 
            580                 585                 590         


Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile 
        595                 600                 605             


Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly 
    610                 615                 620                 


Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala 
625                 630                 635                 640 


Arg Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala 
                645                 650                 655     


Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu Gln Leu 
            660                 665                 670         


Asp Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe Ala Arg Thr Ser 
        675                 680                 685             


Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala 
    690                 695                 700                 


Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys 
705                 710                 715                 720 


Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser 
                725                 730                 735     


Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile 
            740                 745                 750         


Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys 
        755                 760                 765             


Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe 
    770                 775                 780                 


Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr Val Thr 
785                 790                 795                 800 


Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu 
                805                 810                 815     


Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn 
            820                 825                 830         


Pro Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr 
        835                 840                 845             


Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr Tyr Phe 
    850                 855                 860                 


Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His Leu Leu Gly Leu 
865                 870                 875                 880 


Arg Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val Glu Asp Ser Tyr 
                885                 890                 895     


Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val Glu Phe Thr Cys 
            900                 905                 910         


His Thr Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu 
        915                 920                 925             


Val Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys 
    930                 935                 940                 


Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala 
945                 950                 955                 960 


Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met Tyr Pro 
                965                 970                 975     


Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu Leu Ile 
            980                 985                 990         


Phe Val Tyr Asp Glu Val Arg Lys  Leu Ile Ile Arg Arg  Arg Pro Gly 
        995                 1000                 1005             


Gly Trp  Val Glu Lys Glu Thr  Tyr Tyr 
    1010                 1015         


<210>  21
<211>  3051
<212>  DNA
<213>  Homo sapiens

<400>  21
atggccttta aggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagcaaac      360

gataatctgt acctgggtgt ggtgctatca gccgttgtaa tcataactgg ttgcttctcc      420

tactatcaag aagctaaaag ttcaaagatc atggaatcct tcaaaaacat ggtccctcag      480

caagcccttg tgattcgaaa tggtgagaaa atgagcataa atgcggagga agttgtggtt      540

ggggatctgg tggaagtaaa aggaggagac cgaattcctg ctgacctcag aatcatatct      600

gcaaatggct gcaaggtgga taactcctcg ctcactggtg aatcagaacc ccagactagg      660

tctccagatt tcacaaatga aaaccccctg gagacgagga acattgcctt cttttcaacc      720

aattgtgttg aaggcaccgc acgtggtatt gttgtctaca ctggggatcg cactgtgatg      780

ggaagaattg ccacacttgc ttctgggctg gaaggaggcc agacccccat tgctgcagaa      840

attgaacatt ttatccacat catcacgggt gtggctgtgt tcctgggtgt gtctttcttc      900

atcctttctc tcatccttga gtacacctgg cttgaggctg tcatcttcct catcggtatc      960

atcgtagcca atgtgccgga aggtttgctg gccactgtca cggtctgtct gacacttact     1020

gccaaacgca tggcaaggaa aaactgctta gtgaagaact tagaagctgt ggagaccttg     1080

gggtccacgt ccaccatctg ctctgataaa actggaactc tgactcagaa ccggatgaca     1140

gtggcccaca tgtggtttga caatcaaatc catgaagctg atacgacaga gaatcagagt     1200

ggtgtctctt ttgacaagac ttcagctacc tggcttgctc tgtccagaat tgcaggtctt     1260

tgtaacaggg cagtgtttca ggctaaccag gaaaacctac ctattcttaa gcgggcagtt     1320

gcaggagatg cctctgagtc agcactctta aagtgcatag agctgtgctg tggttccgtg     1380

aaggagatga gagaaagata cgccaaaatc gtcgagatac ccttcaactc caccaacaag     1440

taccagttgt ctattcataa gaaccccaac acatcggagc cccaacacct gttggtgatg     1500

aagggcgccc cagaaaggat cctagaccgt tgcagctcta tcctcctcca cggcaaggag     1560

cagcccctgg atgaggagct gaaagacgcc tttcagaacg cctatttgga gctggggggc     1620

ctcggagaac gagtcctagg tttctgccac ctctttctgc cagatgaaca gtttcctgaa     1680

gggttccagt ttgacactga cgatgtgaat ttccctatcg ataatctgtg ctttgttggg     1740

ctcatctcca tgattgaccc tccacgggcg gccgttcctg atgccgtggg caaatgtcga     1800

agtgctggaa ttaaggtcat catggtcaca ggagaccatc caatcacagc taaagctatt     1860

gccaaaggtg tgggcatcat ctcagaaggc aatgagaccg tggaagacat tgctgcccgc     1920

ctcaacatcc cagtcagcca ggtgaacccc agggatgcca aggcctgcgt agtacacggc     1980

agtgatctaa aggacatgac ctccgagcag ctggatgaca ttttgaagta ccacactgag     2040

atagtgtttg ccaggacctc ccctcagcag aagctcatca ttgtggaagg ctgccaaaga     2100

cagggtgcta tcgtggctgt gactggtgac ggtgtgaatg actctccagc tttgaagaaa     2160

gcagacattg gggttgctat ggggattgct ggctcagatg tgtccaagca agctgctgac     2220

atgattcttc tggatgacaa ctttgcctca attgtgactg gagtagagga aggtcgtctg     2280

atctttgata acttgaagaa atccattgct tataccttaa ccagtaacat tcccgagatc     2340

accccgttcc tgatatttat tattgcaaac attccactac cactggggac tgtcaccatc     2400

ctctgcattg acttgggcac tgacatggtt cctgccatct ccctggctta tgagcaggct     2460

gagagtgaca tcatgaagag acagcccaga aatcccaaaa cagacaaact tgtgaatgag     2520

cggctgatca gcatggccta tgggcagatt ggaatgatcc aggccctggg aggcttcttt     2580

acttactttg tgattctggc tgagaacggc ttcctcccaa ttcacctgtt gggcctccga     2640

gtggactggg atgaccgctg gatcaacgat gtggaagaca gctacgggca gcagtggacc     2700

tatgagcaga ggaaaatcgt ggagttcacc tgccacacag ccttcttcgt cagtatcgtg     2760

gtggtgcagt gggccgactt ggtcatctgt aagaccagga ggaattcggt cttccagcag     2820

gggatgaaga acaagatctt gatatttggc ctctttgaag agacagccct ggctgctttc     2880

ctttcctact gccctggaat gggtgttgct cttaggatgt atcccctcaa acctacctgg     2940

tggttctgtg ccttccccta ctctcttctc atcttcgtat atgacgaagt cagaaaactc     3000

atcatcaggc gacgccctgg cggctgggtg gagaaggaaa cctactatta g              3051


<210>  22
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Asn Asp Asn Leu Tyr Leu Gly Val Val 
        115                 120                 125             


Leu Ser Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu 
    130                 135                 140                 


Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln 
145                 150                 155                 160 


Gln Ala Leu Val Ile Arg Asn Gly Glu Lys Met Ser Ile Asn Ala Glu 
                165                 170                 175     


Glu Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly Asp Arg Ile 
            180                 185                 190         


Pro Ala Asp Leu Arg Ile Ile Ser Ala Asn Gly Cys Lys Val Asp Asn 
        195                 200                 205             


Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Phe 
    210                 215                 220                 


Thr Asn Glu Asn Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe Ser Thr 
225                 230                 235                 240 


Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Val Tyr Thr Gly Asp 
                245                 250                 255     


Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Gly 
            260                 265                 270         


Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Ile Ile 
        275                 280                 285             


Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu 
    290                 295                 300                 


Ile Leu Glu Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile 
305                 310                 315                 320 


Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys 
                325                 330                 335     


Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys 
            340                 345                 350         


Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser 
        355                 360                 365             


Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met 
    370                 375                 380                 


Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asn Gln Ser 
385                 390                 395                 400 


Gly Val Ser Phe Asp Lys Thr Ser Ala Thr Trp Leu Ala Leu Ser Arg 
                405                 410                 415     


Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Gln Ala Asn Gln Glu Asn 
            420                 425                 430         


Leu Pro Ile Leu Lys Arg Ala Val Ala Gly Asp Ala Ser Glu Ser Ala 
        435                 440                 445             


Leu Leu Lys Cys Ile Glu Leu Cys Cys Gly Ser Val Lys Glu Met Arg 
    450                 455                 460                 


Glu Arg Tyr Ala Lys Ile Val Glu Ile Pro Phe Asn Ser Thr Asn Lys 
465                 470                 475                 480 


Tyr Gln Leu Ser Ile His Lys Asn Pro Asn Thr Ser Glu Pro Gln His 
                485                 490                 495     


Leu Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser 
            500                 505                 510         


Ser Ile Leu Leu His Gly Lys Glu Gln Pro Leu Asp Glu Glu Leu Lys 
        515                 520                 525             


Asp Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg 
    530                 535                 540                 


Val Leu Gly Phe Cys His Leu Phe Leu Pro Asp Glu Gln Phe Pro Glu 
545                 550                 555                 560 


Gly Phe Gln Phe Asp Thr Asp Asp Val Asn Phe Pro Ile Asp Asn Leu 
                565                 570                 575     


Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val 
            580                 585                 590         


Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met 
        595                 600                 605             


Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val 
    610                 615                 620                 


Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg 
625                 630                 635                 640 


Leu Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys 
                645                 650                 655     


Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu Gln Leu Asp 
            660                 665                 670         


Asp Ile Leu Lys Tyr His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro 
        675                 680                 685             


Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile 
    690                 695                 700                 


Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys 
705                 710                 715                 720 


Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys 
                725                 730                 735     


Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val 
            740                 745                 750         


Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser 
        755                 760                 765             


Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu 
    770                 775                 780                 


Ile Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr Val Thr Ile 
785                 790                 795                 800 


Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala 
                805                 810                 815     


Tyr Glu Gln Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro 
            820                 825                 830         


Lys Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly 
        835                 840                 845             


Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr Tyr Phe Val 
    850                 855                 860                 


Ile Leu Ala Glu Asn Gly Phe Leu Pro Ile His Leu Leu Gly Leu Arg 
865                 870                 875                 880 


Val Asp Trp Asp Asp Arg Trp Ile Asn Asp Val Glu Asp Ser Tyr Gly 
                885                 890                 895     


Gln Gln Trp Thr Tyr Glu Gln Arg Lys Ile Val Glu Phe Thr Cys His 
            900                 905                 910         


Thr Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Val 
        915                 920                 925             


Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn 
    930                 935                 940                 


Lys Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe 
945                 950                 955                 960 


Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met Tyr Pro Leu 
                965                 970                 975     


Lys Pro Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu Leu Ile Phe 
            980                 985                 990         


Val Tyr Asp Glu Val Arg Lys Leu  Ile Ile Arg Arg Arg  Pro Gly Gly 
        995                 1000                 1005             


Trp Val  Glu Lys Glu Thr Tyr  Tyr 
    1010                 1015     


<210>  23
<211>  96
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 1 (ATP1A1-G1)

<400>  23
gaacucacau uaucguuuug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  24
<211>  96
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 2 (ATP1A1-G2)

<400>  24
gauccaagcu gcuacagaag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  25
<211>  96
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 3 (ATP1A1-G3)

<400>  25
gaguucugua auucagcaua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  26
<211>  96
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 4 (ATP1A1-G4)

<400>  26
guuccucuuc uguagcagcu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  27
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  27
gaactcacat tatcgttttg                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  28
atccaagctg ctacagaag                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  29
gagttctgta attcagcata                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  30
gttcctcttc tgtagcagct                                                   20


<210>  31
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Cas9 CRISPR nuclease recognition sequence

<400>  31
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  32
<211>  40
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 5 (ATP1A1-G5)

<400>  32
uaauuucuac ucuuguagau uuucuuggcu uauagcaucc                             40


<210>  33
<211>  40
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 6 (ATP1A1-G6)

<400>  33
uaauuucuac ucuuguagau uuggcuuaua gcauccaagc                             40


<210>  34
<211>  40
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 7 (ATP1A1-G7)

<400>  34
uaauuucuac ucuuguagau agguuccucu ucuguagcag                             40


<210>  35
<211>  40
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 8 (ATP1A1-G8)

<400>  35
uaauuucuac ucuuguagau gagguuccuc uucuguagca                             40


<210>  36
<211>  40
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) 9 (ATP1A1-G9)

<400>  36
uaauuucuac ucuuguagau uaguacacau cagauaucuu                             40


<210>  37
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  37
tttcttggct tatagcatcc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  38
ttggcttata gcatccaagc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  39
aggttcctct tctgtagcag                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  40
gaggttcctc ttctgtagca                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  41
tagtacacat cagatatctt                                                   20


<210>  42
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  CRISPR recognition sequence for AsCpf1

<400>  42
uaauuucuac ucuuguagau                                                   20


<210>  43
<211>  136
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ssODN DR

<400>  43
caatgttact gtggattgga gcgattcttt gtttcttggc ttatagcatc gatgctgcta       60

cagaagagga acctcaaaac gatcgtgtga gttctgtaat tcagcatatc gatttgtagt      120

acacatcaga tatctt                                                      136


<210>  44
<211>  136
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ssODN RD

<400>  44
caatgttact gtggattgga gcgattcttt gtttcttggc ttatagcatc agagctgcta       60

cagaagagga acctcaaaac gatgacgtga gttctgtaat tcagcatatc gatttgtagt      120

acacatcaga tatctt                                                      136


<210>  45
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  45

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  46
<211>  1307
<212>  PRT
<213>  Acidaminococcus

<400>  46

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  47
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  47
cgttgggacc atctcgcgcc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  48
gtagctggac ggttgcaata                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  49
attgcaaccg tccagctacc                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  50
gctgagatcc tggcgcgaga                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  51
caaccgtcca gctaccaggt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  52
gtatattgcc ttgtaagtgc                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  53
caatatacct acctggtagc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  54
tacaaggcaa tatacctacc                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  55
cgacaaaact tgatccattc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  56
ttgatccatt caggagtagt                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  57
aagttttgtc ggcagctctt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  58
agttttgtcg gcagctcttt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  59
gaactcacat tatcgttttg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  60
atacctacct ggtagctgga                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  61
cttgatccat tcaggagtag                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  62
cccctcccac tactcctgaa                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  63
acggttgcaa taaggattta                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  64
tccattcagg agtagtggga                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  65
ttttgtcggc agctctttgg                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  66
ctgaatggat caagttttgt                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  67
aaactgtacc agcacttaca                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  68
atccattcag gagtagtggg                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  69
aattaccact cattacttaa                                                   20


<210>  70
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  70
atccaagctg ctacagaag                                                    19


<210>  71
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  71
ccattcagga gtagtgggag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  72
gttttgtcgg cagctctttg                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  73
tggagcgatt ctttgtttct                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  74
ttctcaatgt tactgtggat                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  75
gggggttctc aatgttactg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  76
tgctcgtgca gctgagatcc                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  77
tgttaatccc tgagaagcag                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  78
agtggtaatt gagaagaagt                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  79
tttgtcggca gctctttggg                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  80
gagtggtaat tgagaagaag                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  81
cattcaggag tagtgggagg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  82
gaagcagtgg aatataaata                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  83
tttatattcc actgcttctc                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  84
ttatattcca ctgcttctca                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  85
ggagggggag tgagggcgtt                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  86
gggaggggga gtgagggcgt                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  87
agtagtggga gggggagtga                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  88
gaagaagtgg gagacaaaga                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  89
gagtagtggg agggggagtg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  90
tcagccgttg taatcataac                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  91
aaaagacaag ttagggcccg                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  92
cgtggctcta cacaataatt                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  93
gacaaagcgt ctggtacctg                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  94
ggggctgtca agtcatccac                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  95
gtggctctac acaataatta                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  96
taattattgt gtagagccac                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  97
gcaaccagtt atgattacaa                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  98
ttaacttcac actaattcac                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  99
ctgagggacc atgtttttga                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  100
cttcaaaaac atggtccctc                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  101
aattcacagg ctgacatgct                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  102
acaaagcgtc tggtacctga                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  103
cggctgatag caccacaccc                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  104
ggctgtcaag tcatccactg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  105
gtcaagtcat ccactgggga                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  106
acacccaggt acagctggaa                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  107
ttcacaggct gacatgcttg                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  108
tgtgaattag tgtgaagtta                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  109
gggctgtcaa gtcatccact                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  110
attcacaggc tgacatgctt                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  111
tttcccttcc agctgtacct                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  112
gacgctttgt ccttccccag                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  113
ctggggaagg acaaagcgtc                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  114
gcaccacacc caggtacagc                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  115
cacacccagg tacagctgga                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  116
ttttcccttc cagctgtacc                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  117
catggaatcc ttcaaaaaca                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  118
cttccagctg tacctgggtg                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  119
acttttagct tcttgatagt                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  120
agctaaaagt tcaaagatca                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  121
ggaagggaaa agacaagtta                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  122
tggaagggaa aagacaagtt                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  123
ctaattattg tgtagagcca                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  124
tctttttaag gcaccgcacg                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  125
atcgtagcca atgtgccgga                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  126
tggctacgat gataccgatg                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  127
gtagacaaca ataccacgtg                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  128
cgtggtattg ttgtctacac                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  129
tatcatcgta gccaatgtgc                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  130
ctggccactg tcacggtaag                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  131
cgtgcggtgc cttaaaaaga                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  132
caatgtgccg gaaggtttgc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  133
tatccacatc atcacgggtg                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  134
cagcaaacct tccggcacat                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  135
cctgcctctt accgtgacag                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  136
gtggtattgt tgtctacact                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  137
cctaattgta tctaacctga                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  138
cgtgcaagct gatctgagtc                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  139
atgtaattgt gtaaaatccg                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  140
ccactgtcac ggtaagaggc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  141
cagccacacc cgtgatgatg                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  142
actggggatc gcactgtgat                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  143
cggattttac acaattacat                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  144
cactggggat cgcactgtga                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  145
tcttccgcta tcctattcta                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  146
ccttcaggtt agatacaatt                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  147
ccttgagtac acctggcttg                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  148
agttggcaat accttagaat                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  149
taaaatccgt ggcttccttc                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  150
ctctcatcct tgagtacacc                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  151
tgcggtgcct taaaaagaag                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  152
acagtggcca gcaaaccttc                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  153
cctcaagcca ggtgtactca                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  154
gtgcggtgcc ttaaaaagaa                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  155
gtgcaagctg atctgagtca                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  156
agaattgcca cacttgcttc                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  157
tggtattgtt gtctacactg                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  158
gaattgccac acttgcttct                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  159
tgccacactt gcttctgggc                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  160
aataccttag aataggatag                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  161
gttcaatttc tgcagcaatg                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  162
aggtttgctg gccactgtca                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  163
tcacggtaag aggcaggtga                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  164
acattttatc cacatcatca                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  165
tttctgcagc aatgggggtc                                                   20


<210>  166
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  166
atctaacctg aaggaagcca                                                   20


<210>  167
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  167
gaggctgtca tcttcctcat                                                   20


<210>  168
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  168
tgttcaattt ctgcagcaat                                                   20


<210>  169
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  169
ttcaatttct gcagcaatgg                                                   20


<210>  170
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  170
ggtgccttaa aaagaagggg                                                   20


<210>  171
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  171
acacttgctt ctgggctgga                                                   20


<210>  172
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  172
gaagatgaca gcctcaagcc                                                   20


<210>  173
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  173
ggatgaagaa agacacaccc                                                   20


<210>  174
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  174
ttccagccca gaagcaagtg                                                   20


<210>  175
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  175
acgggtgtgg ctgtgttcct                                                   20


<210>  176
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  176
cacgggtgtg gctgtgttcc                                                   20


<210>  177
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  177
cttgcttctg ggctggaagg                                                   20


<210>  178
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  178
cattttatcc acatcatcac                                                   20


<210>  179
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  179
tgtactcaag gatgagagaa                                                   20


<210>  180
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  180
tctccctccc cttcttttta                                                   20


<210>  181
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  181
gtgccttaaa aagaagggga                                                   20


<210>  182
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  182
atgttcaatt tctgcagcaa                                                   20


<210>  183
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  183
agccacctgc tgacttcgct                                                   20


<210>  184
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  184
ttactgccaa acgcatggca                                                   20


<210>  185
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  185
gattattact tcactcaacc                                                   20


<210>  186
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  186
gacacttact gccaaacgca                                                   20


<210>  187
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  187
gtttttcctt gccatgcgtt                                                   20


<210>  188
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  188
gactcagaac cggatgacag                                                   20


<210>  189
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  189
attacttcac tcaaccaggc                                                   20


<210>  190
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  190
gatggtggac gtggacccca                                                   20


<210>  191
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  191
tctctgtcgt atcagcttca                                                   20


<210>  192
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  192
gctgaggtgt gtggtaaccc                                                   20


<210>  193
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  193
aaccaagcga agtcagcagg                                                   20


<210>  194
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  194
accatctgct ctgataaaac                                                   20


<210>  195
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  195
aaaaaccaag cgaagtcagc                                                   20


<210>  196
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  196
tttgattgtc aaaccacatg                                                   20


<210>  197
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  197
ggatgacagt ggcccacatg                                                   20


<210>  198
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  198
ttagaagctg tggagacctt                                                   20


<210>  199
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  199
tagaagctgt ggagaccttg                                                   20


<210>  200
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  200
ctggaactct gactcagaac                                                   20


<210>  201
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  201
atctgtatag aattccagcc                                                   20


<210>  202
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  202
acatgtgggc cactgtcatc                                                   20


<210>  203
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  203
gaatcagagt ggtaaggcca                                                   20


<210>  204
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  204
tccagtttta tcagagcaga                                                   20


<210>  205
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  205
agttttatca gagcagatgg                                                   20


<210>  206
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  206
attcttgcta tatcctaatg                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  207
atcagagcag atggtggacg                                                   20


<210>  208
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  208
agaatcagag tggtaaggcc                                                   20


<210>  209
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  209
gacagagaat cagagtggta                                                   20


<210>  210
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  210
agtgaagaac ttagaagctg                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  211
cttagaagct gtggagacct                                                   20


<210>  212
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  212
agacaaattt cttccacatt                                                   20


<210>  213
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  213
gatacgacag agaatcagag                                                   20


<210>  214
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  214
gcgaagtcag caggtggctg                                                   20


<210>  215
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  215
agacagacct aaaaaatatt                                                   20


<210>  216
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  216
ttgattgtca aaccacatgt                                                   20


<210>  217
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  217
taatcttcct aatatttttt                                                   20


<210>  218
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  218
cagcaggtgg ctgaggtgtg                                                   20


<210>  219
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  219
gtcacagatc gatagtagtg                                                   20


<210>  220
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  220
tatcaggaac ggggtgatct                                                   20


<210>  221
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  221
ctcgggaatg ttactggtta                                                   20


<210>  222
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  222
ggtgatctcg ggaatgttac                                                   20


<210>  223
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  223
gcaaacattc cactaccact                                                   20


<210>  224
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  224
atcaggaacg gggtgatctc                                                   20


<210>  225
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  225
tgcaaacatt ccactaccac                                                   20


<210>  226
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  226
acgccagcct catggatgct                                                   20


<210>  227
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  227
caaacattcc actaccactg                                                   20


<210>  228
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  228
gcatccatga ggctggcgtt                                                   20


<210>  229
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  229
gtgacagtcc ccagtggtag                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  230
agcttatgag acaagcacac                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  231
aacgccagcc tcatggatgc                                                   20


<210>  232
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  232
caccatcctc tgcattgact                                                   20


<210>  233
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  233
cattgacttg ggcactgaca                                                   20


<210>  234
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  234
cagtgcccaa gtcaatgcag                                                   20


<210>  235
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  235
agcatccatg aggctggcgt                                                   20


<210>  236
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  236
accatcctct gcattgactt                                                   20


<210>  237
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  237
tgagctgtgt cttcattcac                                                   20


<210>  238
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  238
ctatgctccc agcatccatg                                                   20


<210>  239
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  239
actggttaag gtataagcaa                                                   20


<210>  240
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  240
atacagaaat ggatgctaat                                                   20


<210>  241
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  241
gcccaagtca atgcagagga                                                   20


<210>  242
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  242
aggatggtga cagtccccag                                                   20


<210>  243
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  243
caataataaa tatcaggaac                                                   20


<210>  244
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  244
gctcccagca tccatgaggc                                                   20


<210>  245
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  245
tatacagaaa tggatgctaa                                                   20


<210>  246
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  246
aataataaat atcaggaacg                                                   20


<210>  247
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  247
atccatttct gtatacttct                                                   20


<210>  248
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  248
tgtttgcaat aataaatatc                                                   20


<210>  249
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  249
atccaagaag tatacagaaa                                                   20


<210>  250
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  250
gcaataataa atatcaggaa                                                   20


<210>  251
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  251
taaaaaatct tggttttcat                                                   20


<210>  252
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  252
aagctaacag taaaaaatct                                                   20


<210>  253
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  253
aaatcaacct caacctgagg                                                   20


<210>  254
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  254
cggctgatca gcatggccta                                                   20


<210>  255
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  255
atggtgtcca cctcaggttg                                                   20


<210>  256
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  256
gtgggaagct ggcacatcta                                                   20


<210>  257
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  257
gaatgagcgg ctgatcagca                                                   20


<210>  258
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  258
cagcttacca atctgcccat                                                   20


<210>  259
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  259
tctcagcctg ctcataagcc                                                   20


<210>  260
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  260
ggctgatcag catggcctat                                                   20


<210>  261
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  261
ctcagcctgc tcataagcca                                                   20


<210>  262
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  262
agcatggcct atgggcagat                                                   20


<210>  263
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  263
ctgaaatcaa cctcaacctg                                                   20


<210>  264
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  264
cagacaaact tgtgaatgag                                                   20


<210>  265
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  265
atctaaggca tctgaggtga                                                   20


<210>  266
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  266
atttcagaga ctgcaaatcc                                                   20


<210>  267
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  267
catctccctg gcttatgagc                                                   20


<210>  268
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  268
tggcacatct aaggcatctg                                                   20


<210>  269
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  269
cagattggta agctgcagcc                                                   20


<210>  270
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  270
atgtgccagc ttcccactcc                                                   20


<210>  271
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  271
attcacaagt ttgtctgttt                                                   20


<210>  272
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  272
ctgctcataa gccagggaga                                                   20


<210>  273
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  273
ggtaagctgc agcctggagt                                                   20


<210>  274
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  274
tcataagcca gggagatggc                                                   20


<210>  275
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  275
ggcaagaatt ttataacaaa                                                   20


<210>  276
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  276
gaggtgatgg tgtccacctc                                                   20


<210>  277
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  277
ttcacaagtt tgtctgtttt                                                   20


<210>  278
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  278
ttgtctgttt tgggatttct                                                   20


<210>  279
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  279
gaatttagtt actaaaaata                                                   20


<210>  280
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  280
tgcagcctgg agtgggaagc                                                   20


<210>  281
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  281
agatggcagg aacctgggaa                                                   20


<210>  282
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  282
ccaggttcct gccatctccc                                                   20


<210>  283
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  283
tggtaagctg cagcctggag                                                   20


<210>  284
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  284
gagatggcag gaacctggga                                                   20


<210>  285
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  285
tttgtctgtt ttgggatttc                                                   20


<210>  286
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  286
gcaggaacct gggaaggggt                                                   20


<210>  287
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  287
caggaacctg ggaaggggtg                                                   20


<210>  288
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  288
ccttctcccc accccttccc                                                   20


<210>  289
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  289
ccagggagat ggcaggaacc                                                   20


<210>  290
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  290
cctgggaagg ggtggggaga                                                   20


<210>  291
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  291
ggcaggaacc tgggaagggg                                                   20


<210>  292
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  292
cagggagatg gcaggaacct                                                   20


<210>  293
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  293
gatggcagga acctgggaag                                                   20


<210>  294
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  294
agccttcttc gtcagtatcg                                                   20


<210>  295
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  295
tgaccgctgg atcaacgatg                                                   20


<210>  296
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  296
caccacgata ctgacgaaga                                                   20


<210>  297
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  297
agtccactcg gaggcccaac                                                   20


<210>  298
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  298
tgttgggcct ccgagtggac                                                   20


<210>  299
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  299
gtgtgtgagg ttctagtaat                                                   20


<210>  300
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  300
cggaggccca acaggtgaat                                                   20


<210>  301
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  301
acgatgtgga agacagctac                                                   20


<210>  302
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  302
ggtggtgcag tgggccgact                                                   20


<210>  303
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  303
ggcctggatc attcctaagt                                                   20


<210>  304
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  304
gaggaattcg gtcttccagc                                                   20


<210>  305
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  305
cttcttcgtc agtatcgtgg                                                   20


<210>  306
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  306
cttccacatc gttgatccag                                                   20


<210>  307
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  307
gttgggcctc cgagtggact                                                   20


<210>  308
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  308
ggcccaacag gtgaattggg                                                   20


<210>  309
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  309
tcacctgttg ggcctccgag                                                   20


<210>  310
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  310
tcccaactta ggaatgatcc                                                   20


<210>  311
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  311
ctggaagacc gaattcctcc                                                   20


<210>  312
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  312
aggaattcgg tcttccagca                                                   20


<210>  313
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  313
ggaggcccaa caggtgaatt                                                   20


<210>  314
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  314
gcctggatca ttcctaagtt                                                   20


<210>  315
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  315
gagtggactg ggatgaccgc                                                   20


<210>  316
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  316
ggtcatccca gtccactcgg                                                   20


<210>  317
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  317
agacagctac gggcagcagt                                                   20


<210>  318
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  318
ctatgagcag aggaaaatcg                                                   20


<210>  319
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  319
ttcctcccaa ttcacctgtt                                                   20


<210>  320
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  320
gaggagctct gacactggtc                                                   20


<210>  321
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  321
tgtgtgaggt tctagtaatt                                                   20


<210>  322
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  322
cagtatcgtg gtggtgcagt                                                   20


<210>  323
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  323
aagacagcta cgggcagcag                                                   20


<210>  324
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  324
cttcctccca attcacctgt                                                   20


<210>  325
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  325
catttcagac ctatgagcag                                                   20


<210>  326
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  326
tcagtatcgt ggtggtgcag                                                   20


<210>  327
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  327
agcggtcatc ccagtccact                                                   20


<210>  328
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  328
ttaggaatga tccaggccct                                                   20


<210>  329
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  329
aacgatgtgg aagacagcta                                                   20


<210>  330
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  330
cacgattttc ctctgctcat                                                   20


<210>  331
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  331
gtaagtaaag aagcctccca                                                   20


<210>  332
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  332
acttggtcat ctgtaagacc                                                   20


<210>  333
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  333
tactgacgaa gaaggctgtg                                                   20


<210>  334
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  334
caggcctggg agagcacata                                                   20


<210>  335
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  335
tggtcatctg taagaccagg                                                   20


<210>  336
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  336
taatcagctg aaggctatac                                                   20


<210>  337
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  337
ttactagaac ctcacacaca                                                   20


<210>  338
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  338
ctgctgcagt aatcagctga                                                   20


<210>  339
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  339
tactagaacc tcacacacaa                                                   20


<210>  340
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  340
tacaggtacc cttgtgtgtg                                                   20


<210>  341
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  341
ggcttgagga gctctgacac                                                   20


<210>  342
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  342
cttaggaatg atccaggccc                                                   20


<210>  343
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  343
tggctcttca cctgcatggc                                                   20


<210>  344
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  344
agtaagtaaa gaagcctccc                                                   20


<210>  345
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  345
ctgtaagacc aggaggaatt                                                   20


<210>  346
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  346
ctgattactg cagcaggcct                                                   20


<210>  347
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  347
cttcagctga ttactgcagc                                                   20


<210>  348
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  348
tctgacactg gtcaggtcag                                                   20


<210>  349
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  349
gctgattact gcagcaggcc                                                   20


<210>  350
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  350
acgggcagca gtgggtgagt                                                   20


<210>  351
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  351
ggtcttacag atgaccaagt                                                   20


<210>  352
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  352
ttgggttgtt ttcccaactt                                                   20


<210>  353
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  353
ctcttcacct gcatggctgg                                                   20


<210>  354
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  354
gctctggctc ttcacctgca                                                   20


<210>  355
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  355
cctcaagccc cagaagactg                                                   20


<210>  356
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  356
ggaatgatcc aggccctggg                                                   20


<210>  357
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  357
agtgtggcct cagtcttctg                                                   20


<210>  358
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  358
gacgaagaag gctgtgtggc                                                   20


<210>  359
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  359
tacgggcagc agtgggtgag                                                   20


<210>  360
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  360
ctttacttac tttgtgattc                                                   20


<210>  361
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  361
cacactgcca ccagccatgc                                                   20


<210>  362
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  362
tttgtgattc tggctgagaa                                                   20


<210>  363
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  363
cctcagtctt ctggggcttg                                                   20


<210>  364
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  364
taaagaagcc tcccagggcc                                                   20


<210>  365
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  365
agaagacaga agatgagctc                                                   20


<210>  366
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  366
gcagtgtggc ctcagtcttc                                                   20


<210>  367
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  367
ctgcatggct ggtggcagtg                                                   20


<210>  368
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  368
cagtgtggcc tcagtcttct                                                   20


<210>  369
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  369
aacatatgac acatatagcc                                                   20


<210>  370
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  370
ttacttactt catcccctgc                                                   20


<210>  371
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  371
cttggctcaa agaaggggac                                                   20


<210>  372
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  372
tgaaggacat gtcaaggcct                                                   20


<210>  373
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  373
cagtcccctt ctttgagcca                                                   20


<210>  374
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  374
aagtaatgaa ggacatgtca                                                   20


<210>  375
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  375
tcaaggcctt ggctcaaaga                                                   20


<210>  376
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  376
aaggccttgg ctcaaagaag                                                   20


<210>  377
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  377
caaggccttg gctcaaagaa                                                   20


<210>  378
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  378
atatgtttag tttttggcaa                                                   20


<210>  379
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  379
ggggatgaag taagtaatga                                                   20


<210>  380
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  380
tgtgtcatat gtttagtttt                                                   20


<210>  381
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  381
tatgtttagt ttttggcaaa                                                   20


<210>  382
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  382
CCAGAGGATCAACTTACTTG							20


<210>  383
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  383
atactttttg gagctaccag                                                   20


<210>  384
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  384
cctcaagtaa gttgatcctc                                                   20


<210>  385
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  385
gcttttcccc ccattacttg                                                   20


<210>  386
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  386
agaggatcaa cttacttgag                                                   20


<210>  387
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  387
actattacca caagtaatgg                                                   20


<210>  388
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  388
ctaagagcaa cacccattcc                                                   20


<210>  389
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  389
cagaggatca acttacttga                                                   20


<210>  390
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  390
caactattac cacaagtaat                                                   20


<210>  391
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  391
taagagcaac acccattcca                                                   20


<210>  392
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  392
ctggaatggg tgttgctctt                                                   20


<210>  393
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  393
acaactatta ccacaagtaa                                                   20


<210>  394
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  394
aggaacaaga tcttgatatt                                                   20


<210>  395
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  395
aactattacc acaagtaatg                                                   20


<210>  396
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  396
aacacccatt ccagggcagt                                                   20


<210>  397
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  397
cctttcctac tgccctggaa                                                   20


<210>  398
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  398
ctttcctact gccctggaat                                                   20


<210>  399
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  399
cctctttgaa gagacagccc                                                   20


<210>  400
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  400
ccagggctgt ctcttcaaag                                                   20


<210>  401
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  401
tgttcctaaa atcaaagtag                                                   20


<210>  402
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  402
tctaatgcta tgcattaaaa                                                   20


<210>  403
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  403
ccattccagg gcagtaggaa                                                   20


<210>  404
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  404
ttgttcctaa aatcaaagta                                                   20


<210>  405
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  405
gctttccttt cctactgccc                                                   20


<210>  406
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  406
aacttaaaag gtgcaaataa                                                   20


<210>  407
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  407
aaagtatgaa atagtatgtg                                                   20


<210>  408
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  408
ctattaccac aagtaatggg                                                   20


<210>  409
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  409
acatactatt tcatactttt                                                   20


<210>  410
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  410
ttctccccta ctttgatttt                                                   20


<210>  411
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  411
taggggagaa aaaacttaaa                                                   20


<210>  412
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  412
gtaggaaagg aaagcagcca                                                   20


<210>  413
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  413
cttgttccta aaatcaaagt                                                   20


<210>  414
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  414
agtaggaaag gaaagcagcc                                                   20


<210>  415
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  415
gacgccctgg cggtaattat                                                   20


<210>  416
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  416
gaatgcccat aattaccgcc                                                   20


<210>  417
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  417
cgacgccctg gcggtaatta                                                   20


<210>  418
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  418
ctcatcatca ggcgacgccc                                                   20


<210>  419
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  419
aatgcccata attaccgcca                                                   20


<210>  420
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  420
gggaggggct atagttctat                                                   20


<210>  421
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  421
atcatcaggc gacgccctgg                                                   20


<210>  422
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  422
gagggagcct agacaccttg                                                   20


<210>  423
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  423
agggagccta gacaccttga                                                   20


<210>  424
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  424
actctatttc cagacctacc                                                   20


<210>  425
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  425
acagaaccac caggtaggtc                                                   20


<210>  426
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  426
ggcattctga ctttggttgg                                                   20


<210>  427
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  427
ttgtttccct caaggtgtct                                                   20


<210>  428
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  428
ctatttccag acctacctgg                                                   20


<210>  429
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  429
atgggcattc tgactttggt                                                   20


<210>  430
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  430
aggtgtctag gctccctcag                                                   20


<210>  431
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  431
aaggcacaga accaccaggt                                                   20


<210>  432
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  432
aagtcagaaa actcatcatc                                                   20


<210>  433
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  433
gctgattatt tcattgtcac                                                   20


<210>  434
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  434
gtaggtctgg aaatagagta                                                   20


<210>  435
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  435
attctgactt tggttggagg                                                   20


<210>  436
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  436
ggggaaggca cagaaccacc                                                   20


<210>  437
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  437
tacgaagatg agaagagagt                                                   20


<210>  438
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  438
aattatgggc attctgactt                                                   20


<210>  439
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  439
gtgttcgtgt gcatataaat                                                   20


<210>  440
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  440
actttggttg gaggaggagt                                                   20


<210>  441
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  441
acgaagatga gaagagagta                                                   20


<210>  442
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  442
cgaagatgag aagagagtag                                                   20


<210>  443
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  443
gactttggtt ggaggaggag                                                   20


<210>  444
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  444
ttggtttttt gtttccctca                                                   20


<210>  445
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  445
ttggttggag gaggagtggg                                                   20


<210>  446
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  446
tggttggagg aggagtggga                                                   20


<210>  447
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  447
gatgagaaga gagtagggga                                                   20


<210>  448
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  448
ggttggagga ggagtgggag                                                   20


<210>  449
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  449
cacttgtaag agcatctaca acg                                               23


<210>  450
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  450
ggattaacat ctgctcgtgc agc                                               23


<210>  451
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  451
ccccttacct ctctagtctg tgc                                               23


<210>  452
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  452
ctcaggttct gggagagggt ag                                                22


<210>  453
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  453
ggtgtggaag tttaatgact aagagg                                            26


<210>  454
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  454
tcactgtaac caagtgaaat gaaagc                                            26


<210>  455
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  455
gatgtgatga aggagatggg                                                   20


<210>  456
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  456
gacagagggc tacaatgtga                                                   20


<210>  457
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  457
ggggctttaa gacgcttact                                                   20


<210>  458
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  458
ttctaatacg actcactata gagttctgta attcagcata gttttagagc taga             54


<210>  459
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  459
atgggccgtg gggctggccg tgagtactca cctgccgcca ccacggcaga gaatgggggc       60

ggcaagaaga aacagaagga gaaggaactg gatgagctga agaaggaggt ggcaatggat      120

gaccacaagc tgtccttgga tgagctgggc cgcaaatacc aagtggacct gtccaagggc      180

ctcaccaacc agcgggctca ggacgttctg gctcgagatg ggcccaacgc cctcacacca      240

cctcccacaa cccctgagtg ggtcaagttc tgccgtcagc ttttcggggg gttctccatc      300

ctgctgtgga ttggggctat cctctgcttc ctggcctacg gcatccaggc tgccatggag      360

gatgaaccat ccaacgacaa tctatatctg ggtgtggtgc tggcagctgt ggtcattgtc      420

actggctgct tctcctacta ccaggaggcc aagagctcca agatcatgga ttccttcaag      480

aacatggtac ctcagcaagc ccttgtgatc cgggagggag agaagatgca gatcaacgca      540

gaggaagtgg tggtgggaga cctggtggag gtgaagggtg gagaccgcgt ccctgctgac      600

ctccggatca tctcttctca tggctgtaag gtggataact catccttaac aggagagtcg      660

gagccccaga cccgctcccc cgagttcacc catgagaacc ccctggagac ccgcaatatc      720

tgtttcttct ccaccaactg tgttgaaggc actgccaggg gcattgtgat tgccacagga      780

gaccggacgg tgatgggccg catagctact ctcgcctcag gcctggaggt tgggcggaca      840

cccatagcaa tggagattga acacttcatc cagctgatca caggggtcgc tgtattcctg      900

ggggtctcct tcttcgtgct ctccctcatc ctgggctaca gctggctgga ggcagtcatc      960

ttcctcatcg gcatcatagt ggccaacgtg cctgaggggc ttctggccac tgtcactgtg     1020

tgcctgaccc tgacagccaa gcgcatggca cggaagaact gcctggtgaa gaacctggag     1080

gcggtggaga cgctgggctc cacgtccacc atctgctcgg acaagacggg caccctcacc     1140

cagaaccgca tgaccgtcgc ccacatgtgg ttcgacaacc aaatccatga ggctgacacc     1200

accgaagatc agtctggggc cacttttgac aaacgatccc ctacgtggac ggccctgtct     1260

cgaattgctg gtctctgcaa ccgcgccgtc ttcaaggcag gacaggagaa catctccgtg     1320

tctaagcggg acacagctgg tgatgcctct gagtcagctc tgctcaagtg cattgagctc     1380

tcctgtggct cagtgaggaa aatgagagac agaaacccca aggtggcaga gattcctttc     1440

aactctacca acaagtacca gctgtctatc cacgagcgag aagacagccc ccagagccac     1500

gtgctggtga tgaagggggc cccagagcgc attctggacc ggtgctccac catcctggtg     1560

cagggcaagg agatcccgct cgacaaggag atgcaagatg cctttcaaaa tgcctacatg     1620

gagctggggg gacttgggga gcgtgtgctg ggattctgtc aactgaatct gccatctgga     1680

aagtttcctc ggggcttcaa attcgacacg gatgagctga actttcccac ggagaagctt     1740

tgctttgtgg ggctcatgtc tatgattgac cctccccggg ctgctgtgcc agatgctgtg     1800

ggcaagtgcc gaagcgcagg catcaaggtg atcatggtaa ccggggatca ccctatcaca     1860

gccaaggcca ttgccaaagg cgtgggcatc atatcagagg gtaacgagac tgtggaggac     1920

attgcagccc ggctcaacat tcccatgagt caagtcaacc ccagagaagc caaggcatgc     1980

gtggtgcacg gctctgacct gaaggacatg acatcggagc agctcgatga gatcctcaag     2040

aaccacacag agatcgtctt tgctcgaacg tctccccagc agaagctcat cattgtggag     2100

ggatgtcaga ggcagggagc cattgtggcc gtgacgggtg acggggtgaa cgactcccct     2160

gcattgaaga aggctgacat tggcattgcc atgggcatct ctggctctga cgtctctaag     2220

caggcagccg acatgatcct gctggatgac aactttgcct ccatcgtcac gggggtggag     2280

gagggccgcc tgatctttga caacttgaag aaatccatcg cctacaccct gaccagcaac     2340

atccccgaga tcaccccctt cctgctgttc atcattgcca acatccccct acctctgggc     2400

actgtgacca tcctttgcat tgacctgggc acagatatgg tccctgccat ctccttggcc     2460

tatgaggcag ctgagagtga tatcatgaag cggcagccac gaaactccca gacggacaag     2520

ctggtgaatg agaggctcat cagcatggcc tacggacaga tcgggatgat ccaggcactg     2580

ggtggcttct tcacctactt tgtgatcctg gcagagaacg gtttcctgcc atcacggcta     2640

ctgggaatcc gcctcgactg ggatgaccgg accatgaatg atctggagga cagctatgga     2700

caggagtgga cctatgagca gcggaaggtg gtggagttca cgtgccacac ggcattcttt     2760

gccagcatcg tggtggtgca gtgggctgac ctcatcatct gcaagacccg ccgcaactca     2820

gtcttccagc agggcatgaa gaacaagatc ctgatttttg ggctcctgga ggagacggcg     2880

ttggctgcct ttctctctta ctgcccaggc atgggtgtag ccctccgcat gtacccgctc     2940

aaagtcacct ggtggttctg cgccttcccc tacagcctcc tcatcttcat ctatgatgag     3000

gtccgaaagc tcatcctgcg gcggtatcct ggtggctggg tggagaagga gacatactac     3060

tga                                                                   3063


<210>  460
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  461
<211>  3635
<212>  DNA
<213>  Homo sapiens

<400>  461
tcccgcggac gcgggcatat gaggaggcgg aggcggcggc cgccgcagcc tctgtgcggt       60

gggaccaacg gacggacgga cggacgcgcg cacctaccga ggcgcgggcg ctgcagaggc      120

tcccagccca agcctgagcc tgagcccgcc ccgaggtccc cgccccgccc gcctggctct      180

ctcgccgcgg agccgccaag atgggggaca agaaagatga caaggactca cccaagaaga      240

acaagggcaa ggagcgccgg gacctggatg acctcaagaa ggaggtggct atgacagagc      300

acaagatgtc agtggaagag gtctgccgga aatacaacac agactgtgtg cagggtttga      360

cccacagcaa agcccaggag atcctggccc gggatgggcc taacgcactc acgccaccgc      420

ctaccacccc agagtgggtc aagttttgcc ggcagctctt cgggggcttc tccatcctgc      480

tgtggatcgg ggctatcctc tgcttcctgg cctacggtat ccaggcgggc accgaggacg      540

acccctctgg tgacaacctg tacctgggca tcgtgctggc ggccgtggtg atcatcactg      600

gctgcttctc ctactaccag gaggccaaga gctccaagat catggagtcc ttcaagaaca      660

tggtgcccca gcaagccctg gtgatccggg aaggtgagaa gatgcaggtg aacgctgagg      720

aggtggtggt cggggacctg gtggagatca agggtggaga ccgagtgcca gctgacctgc      780

ggatcatctc agcccacggc tgcaaggtgg acaactcctc cctgactggc gaatccgagc      840

cccagactcg ctctcccgac tgcactcacg acaacccctt ggagactcgg aacatcacct      900

tcttttccac caactgtgtg gaaggcacgg ctcggggcgt ggtggtggcc acgggcgacc      960

gcactgtcat gggccgtatc gccaccctgg catcagggct ggaggtgggc aagacgccca     1020

tcgccatcga gattgagcac ttcatccagc tcatcaccgg cgtggctgtc ttcctgggtg     1080

tctccttctt catcctctcc ctcattctcg gatacacctg gcttgaggct gtcatcttcc     1140

tcatcggcat catcgtggcc aatgtcccag agggtctgct ggccactgtc actgtgtgtc     1200

tgacgctgac cgccaagcgc atggcccgga agaactgcct ggtgaagaac ctggaggctg     1260

tagaaaccct gggctccacg tccaccatct gctcagataa gacagggacc ctcactcaga     1320

accgcatgac agtcgcccac atgtggtttg acaaccagat ccacgaggct gacaccactg     1380

aggaccagtc agggacctca tttgacaaga gttcgcacac ctgggtggcc ctgtctcaca     1440

tcgctgggct ctgcaatcgc gctgtcttca agggtggtca ggacaacatc cctgtgctca     1500

agagggatgt ggctggggat gcgtctgagt ctgccctgct caagtgcatc gagctgtcct     1560

ctggctccgt gaagctgatg cgtgaacgca acaagaaagt ggctgagatt cccttcaatt     1620

ccaccaacaa ataccagctc tccatccatg agaccgagga ccccaacgac aaccgatacc     1680

tgctggtgat gaagggtgcc cccgagcgca tcctggaccg ctgctccacc atcctgctac     1740

agggcaagga gcagcctctg gacgaggaaa tgaaggaggc cttccagaat gcctaccttg     1800

agctcggtgg cctgggcgag cgcgtgcttg gtttctgcca ttattacctg cccgaggagc     1860

agttccccaa gggctttgcc ttcgactgtg atgacgtgaa cttcaccacg gacaacctct     1920

gctttgtggg cctcatgtcc atgatcgacc caccccgggc agccgtccct gacgcggtgg     1980

gcaagtgtcg cagcgcaggc atcaaggtca tcatggtcac cggcgatcac cccatcacgg     2040

ccaaggccat tgccaagggt gtgggcatca tctctgaggg caacgagact gtggaggaca     2100

tcgccgcccg gctcaacatt cccgtcagcc aggttaaccc ccgggatgcc aaggcctgcg     2160

tgatccacgg caccgacctc aaggacttca cctccgagca aatcgacgag atcctgcaga     2220

atcacaccga gatcgtcttc gcccgcacat ccccccagca gaagctcatc attgtggagg     2280

gctgtcagag acagggtgca attgtggctg tgaccgggga tggtgtgaac gactcccccg     2340

ctctgaagaa ggccgacatt ggggtggcca tgggcatcgc tggctctgac gtctccaagc     2400

aggcagctga catgatcctg ctggacgaca actttgcctc catcgtcaca ggggtggagg     2460

agggccgcct gatcttcgac aacctaaaga agtccattgc ctacaccctg accagcaata     2520

tcccggagat cacgcccttc ctgctgttca tcatggccaa catcccgctg cccctgggca     2580

ccatcaccat cctctgcatc gatctgggca ctgacatggt ccctgccatc tcactggcgt     2640

acgaggctgc cgaaagcgac atcatgaaga gacagcccag gaacccgcgg acggacaaat     2700

tggtcaatga gagactcatc agcatggcct acgggcagat tggaatgatc caggctctcg     2760

gtggcttctt ctcttacttt gtgatcctgg cagaaaatgg cttcttgccc ggcaacctgg     2820

tgggcatccg gctgaactgg gatgaccgca ccgtcaatga cctggaagac agttacgggc     2880

agcagtggac atacgagcag aggaaggtgg tggagttcac ctgccacacg gccttctttg     2940

tgagcatcgt tgtcgtccag tgggccgatc tgatcatctg caagacccgg aggaactcgg     3000

tcttccagca gggcatgaag aacaagatcc tgatcttcgg gctgtttgag gagacggccc     3060

tggctgcctt cctgtcctac tgccccggca tggacgtggc cctgcgcatg taccctctca     3120

agcccagctg gtggttctgt gccttcccct acagtttcct catcttcgtc tacgacgaaa     3180

tccgcaaact catcctgcgc aggaacccag ggggttgggt ggagaaggaa acctactact     3240

gacctcagcc ccaccacatc gcccatctct tccccgtccc ccaggcccag gaccgcccct     3300

gtcagtcccc ccaattttgt attctggggg gaggagccct ctcttcctgt ggccccacct     3360

tggcccccac cccctccact atctcctgcc gcccccactc tggctggctt ctctcccctg     3420

ccccaaacct ctctcctctc tcttttctgt gtcagtttct ctccctctcc tcacccctct     3480

atccattcct cccgccccag ccacctccct gggctctttt ttactcccct tcagcccccc     3540

ggctgatgcc atctctggtt ctggacaatt atcaaatata tcagtgggga gagagaaaaa     3600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                3635


<210>  462
<211>  1013
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
225                 230                 235                 240 


Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                245                 250                 255     


Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                325                 330                 335     


Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
        355                 360                 365             


Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
        595                 600                 605             


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Thr Tyr Tyr 
    1010             


<210>  463
<211>  3090
<212>  DNA
<213>  Homo sapiens

<400>  463
atggggcttt gggggaagaa agggacagtg gctccccatg accagagtcc aagacgaaga       60

cctaaaaaag ggcttatcaa gaaaaaaatg gtgaagaggg aaaaacagaa gcgcaatatg      120

gaggaactga agaaggaagt ggtcatggat gatcacaaat taaccttgga agagctgagc      180

accaagtact ccgtggacct gacaaagggc catagccacc aaagggcaaa ggaaatcctg      240

actcgaggtg gacccaatac tgttacccca ccccccacca ctccagaatg ggtcaaattc      300

tgtaagcaac tgttcggagg cttctccctc ctactatgga ctggggccat tctctgcttt      360

gtggcctaca gcatccagat atatttcaat gaggagccta ccaaagacaa cctctacctg      420

agcatcgtac tgtccgtcgt ggtcatcgtc actggctgct tctcctatta tcaggaggcc      480

aagagctcca agatcatgga gtcttttaag aacatggtgc ctcagcaagc tctggtaatt      540

cgaggaggag agaagatgca aattaatgta caagaggtgg tgttgggaga cctggtggaa      600

atcaagggtg gagaccgagt ccctgctgac ctccggctta tctctgcaca aggatgtaag      660

gtggacaact catccttgac tggggagtca gaaccccaga gccgctcccc tgacttcacc      720

catgagaacc ctctggagac ccgaaacatc tgcttctttt ccaccaactg tgtggaagga      780

accgcccggg gtattgtgat tgctacggga gactccacag tgatgggcag aattgcctcc      840

ctgacgtcag gcctggcggt tggccagaca cctatcgctg ctgagatcga acacttcatc      900

catctgatca ctgtggtggc cgtcttcctt ggtgtcactt tttttgcgct ctcacttctc      960

ttgggctatg gttggctgga ggctatcatt tttctcattg gcatcattgt ggccaatgtg     1020

cctgaggggc tgttggccac agtcactgtg tgcctgaccc tcacagccaa gcgcatggcg     1080

cggaagaact gcctggtgaa gaacctggag gcggtggaga cgctgggctc cacgtccacc     1140

atctgctcag acaagacggg caccctcacc cagaaccgca tgaccgtcgc ccacatgtgg     1200

tttgatatga ccgtgtatga ggccgacacc actgaagaac agactggaaa aacatttacc     1260

aagagctctg atacctggtt tatgctggcc cgaatcgctg gcctctgcaa ccgggctgac     1320

tttaaggcta atcaggagat cctgcccatt gctaagaggg ccacaacagg tgatgcttcc     1380

gagtcagccc tcctcaagtt catcgagcag tcttacagct ctgtggcgga gatgagagag     1440

aaaaacccca aggtggcaga gattcccttt aattctacca acaagtacca gatgtccatc     1500

caccttcggg aggacagctc ccagacccac gtactgatga tgaagggtgc tccggagagg     1560

atcttggagt tttgttctac ctttcttctg aatgggcagg agtactcaat gaacgatgaa     1620

atgaaggaag ccttccaaaa tgcctactta gaactgggag gtctggggga acgtgtgcta     1680

ggcttctgct tcttgaatct gcctagcagc ttctccaagg gattcccatt taatacagat     1740

gaaataaatt tccccatgga caacctttgt tttgtgggcc tcatatccat gattgaccct     1800

ccccgagctg cagtgcctga tgctgtgagc aagtgtcgca gtgcaggaat taaggtgatc     1860

atggtaacag gagatcatcc cattacagct aaggccattg ccaagggtgt gggcatcatc     1920

tcagaaggca ctgagacggc agaggaagtc gctgcccggc ttaagatccc tatcagcaag     1980

gtcgatgcca gtgctgccaa agccattgtg gtgcatggtg cagaactgaa ggacatacag     2040

tccaagcagc ttgatcagat cctccagaac caccctgaga tcgtgtttgc tcggacctcc     2100

cctcagcaga agctcatcat tgtcgaggga tgtcagaggc tgggagccgt tgtggccgtg     2160

acaggtgacg gggtgaacga ctcccctgcg ctgaagaagg ctgacattgg cattgccatg     2220

ggcatctctg gctctgacgt ctctaagcag gcagccgaca tgatcctgct ggatgacaac     2280

tttgcctcca tcgtcacggg ggtggaggag ggccgcctga tctttgacaa cctgaagaaa     2340

tccatcatgt acaccctgac cagcaacatc cccgagatca cgcccttcct gatgttcatc     2400

atcctcggta tacccctgcc tctgggaacc ataaccatcc tctgcattga tctcggcact     2460

gacatggtcc ctgccatctc cttggcttat gagtcagctg aaagcgacat catgaagagg     2520

cttccaagga acccaaagac ggataatctg gtgaaccacc gtctcattgg catggcctat     2580

ggacagattg ggatgatcca ggctctggct ggattcttta cctactttgt aatcctggct     2640

gagaatggtt ttaggcctgt tgatctgctg ggcatccgcc tccactggga agataaatac     2700

ttgaatgacc tggaggacag ctacggacag cagtggacct atgagcaacg aaaagttgtg     2760

gagttcacat gccaaacggc cttttttgtc accatcgtgg ttgtgcagtg ggcggatctc     2820

atcatctcca agactcgccg caactcactt ttccagcagg gcatgagaaa caaagtctta     2880

atatttggga tcctggagga gacactcttg gctgcatttc tgtcctacac tccaggcatg     2940

gacgtggccc tgcgaatgta cccactcaag ataacctggt ggctctgtgc cattccctac     3000

agtattctca tcttcgtcta tgatgaaatc agaaaactcc tcatccgtca gcacccggat     3060

ggctgggtgg aaagggagac gtactactaa                                      3090


<210>  464
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Gly Leu Trp Gly Lys Lys Gly Thr Val Ala Pro His Asp Gln Ser 
1               5                   10                  15      


Pro Arg Arg Arg Pro Lys Lys Gly Leu Ile Lys Lys Lys Met Val Lys 
            20                  25                  30          


Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys Glu Val Val 
        35                  40                  45              


Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr Lys Tyr Ser 
    50                  55                  60                  


Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys Glu Ile Leu 
65                  70                  75                  80  


Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr Thr Pro Glu 
                85                  90                  95      


Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile Gln Ile Tyr 
        115                 120                 125             


Phe Asn Glu Glu Pro Thr Lys Asp Asn Leu Tyr Leu Ser Ile Val Leu 
    130                 135                 140                 


Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
145                 150                 155                 160 


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
                165                 170                 175     


Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn Val Gln Glu 
            180                 185                 190         


Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
        195                 200                 205             


Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val Asp Asn Ser 
    210                 215                 220                 


Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro Asp Phe Thr 
225                 230                 235                 240 


His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn 
                245                 250                 255     


Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Ser 
            260                 265                 270         


Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu Ala Val Gly 
        275                 280                 285             


Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Leu Ile Thr 
    290                 295                 300                 


Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile Gly Ile Ile 
                325                 330                 335     


Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu 
            340                 345                 350         


Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn 
        355                 360                 365             


Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp 
385                 390                 395                 400 


Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu Gln Thr Gly 
                405                 410                 415     


Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu Ala Arg Ile 
            420                 425                 430         


Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln Glu Ile Leu 
        435                 440                 445             


Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu Ser Ala Leu 
    450                 455                 460                 


Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu Met Arg Glu 
465                 470                 475                 480 


Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr 
                485                 490                 495     


Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr His Val Leu 
            500                 505                 510         


Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys Ser Thr Phe 
        515                 520                 525             


Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met Lys Glu Ala 
    530                 535                 540                 


Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu 
545                 550                 555                 560 


Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys Gly Phe Pro 
                565                 570                 575     


Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu Cys Phe Val 
            580                 585                 590         


Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
        595                 600                 605             


Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
    610                 615                 620                 


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
625                 630                 635                 640 


Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg Leu Lys Ile 
                645                 650                 655     


Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile Val Val His 
            660                 665                 670         


Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp Gln Ile Leu 
        675                 680                 685             


Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
    690                 695                 700                 


Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val Val Ala Val 
705                 710                 715                 720 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
                725                 730                 735     


Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala Ala 
            740                 745                 750         


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
        755                 760                 765             


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Met Tyr 
    770                 775                 780                 


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Met Phe Ile 
785                 790                 795                 800 


Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
                805                 810                 815     


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ser 
            820                 825                 830         


Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro Lys Thr Asp 
        835                 840                 845             


Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly Gln Ile Gly 
    850                 855                 860                 


Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
                885                 890                 895     


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
            900                 905                 910         


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
        915                 920                 925             


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
    930                 935                 940                 


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
945                 950                 955                 960 


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
                965                 970                 975     


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
            980                 985                 990         


Trp Trp Leu Cys Ala Ile Pro Tyr  Ser Ile Leu Ile Phe  Val Tyr Asp 
        995                 1000                 1005             


Glu Ile  Arg Lys Leu Leu Ile  Arg Gln His Pro Asp  Gly Trp Val 
    1010                 1015                 1020             


Glu Arg  Glu Thr Tyr Tyr 
    1025                 


<210>  465
<211>  97
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) HPRT1-S1R

<400>  465
gaugugauga aggagauggg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcu                                97


<210>  466
<211>  97
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) HPRT1-S2L

<400>  466
gacagagggc uacaauguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcu                                97


<210>  467
<211>  97
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) HIST1H2BK

<400>  467
ggggcuuuaa gacgcuuacu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcu                                97


<210>  468
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  468
ggggccacta gggacaggat                                                   20


<210>  469
<211>  97
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) AAVS1-T2

<400>  469
ggggccacua gggacaggau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcu                                97


<210>  470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  470
gccatggaga ccccgtccca g                                                 21


<210>  471
<211>  98
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Single guide RNA (sgRNA) LMNA-G2

<400>  471
gccauggaga ccccguccca gguuuuagag cuagaaauag caaguuaaaa uaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcu                               98


<210>  472
<211>  2780
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SA-2A-EGFP-pA donor sequence containing homology arms to AAVS1

<400>  472
tgctttctct gaccagcatt ctctcccctg ggcctgtgcc gctttctgtc tgcagcttgt       60

ggcctgggtc acctctacgg ctggcccaga tccttccctg ccgcctcctt caggttccgt      120

cttcctccac tccctcttcc ccttgctctc tgctgtgttg ctgcccaagg atgctctttc      180

cggagcactt ccttctcggc gctgcaccac gtgatgtcct ctgagcggat cctccccgtg      240

tctgggtcct ctccgggcat ctctcctccc tcacccaacc ccatgccgtc ttcactcgct      300

gggttccctt ttccttctcc ttctggggcc tgtgccatct ctcgtttctt aggatggcct      360

tctccgacgg atgtctccct tgcgtcccgc ctccccttct tgtaggcctg catcatcacc      420

gtttttctgg acaaccccaa agtaccccgt ctccctggct ttagccacct ctccatcctc      480

ttgctttctt tgcctggaca ccccgttctc ctgtggattc gggtcacctc tcactccttt      540

catttgggca gctcccctac cccccttacc tctctagtct gtgctagctc ttccagcccc      600

ctgtcatggc atcttccagg ggtccgagag ctcagctagt cttcttcctc caacccgggc      660

ccctatgtcc acttcaggac agcatgtttg ctgcctccag ggatcctgtg tccccgagct      720

gggaccacct tatattccca gggccggtta atgtggctct ggttctgggt acttttatct      780

gtcccctcca ccccacagtg gggcaagctt ctgacctctt ctcttcctcc cacagggcct      840

cgagagatct ggcagcggag agggcagagg aagtcttcta acatgcggtg acgtggagga      900

gaatcccggc cctaggctcg agatggtgag caagggcgag gagctgttca ccggggtggt      960

gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga     1020

gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa     1080

gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag     1140

ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta     1200

cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt     1260

gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga     1320

ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat     1380

catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga     1440

ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc     1500

cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa     1560

cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg     1620

catggacgag ctgtacaagt aaagcggccg cgtcgagtct agagggcccg tttaaacccg     1680

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     1740

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     1800

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     1860

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggg     1920

tcgacagtac taagctttac tagggacagg attggtgaca gaaaagcccc atccttaggc     1980

ctcctccttc ctagtctcct gatattgggt ctaaccccca cctcctgtta ggcagattcc     2040

ttatctggtg acacaccccc atttcctgga gccatctctc tccttgccag aacctctaag     2100

gtttgcttac gatggagcca gagaggatcc tgggagggag agcttggcag ggggtgggag     2160

ggaagggggg gatgcgtgac ctgcccggtt ctcagtggcc accctgcgct accctctccc     2220

agaacctgag ctgctctgac gcggctgtct ggtgcgtttc actgatcctg gtgctgcagc     2280

ttccttacac ttcccaagag gagaagcagt ttggaaaaac aaaatcagaa taagttggtc     2340

ctgagttcta actttggctc ttcacctttc tagtccccaa tttatattgt tcctccgtgc     2400

gtcagtttta cctgtgagat aaggccagta gccagccccg tcctggcagg gctgtggtga     2460

ggaggggggt gtccgtgtgg aaaactccct ttgtgagaat ggtgcgtcct aggtgttcac     2520

caggtcgtgg ccgcctctac tccctttctc tttctccatc cttctttcct taaagagtcc     2580

ccagtgctat ctgggacata ttcctccgcc cagagcaggg tcccgcttcc ctaaggccct     2640

gctctgggct tctgggtttg agtccttggc aagcccagga gaggcgctca ggcttccctg     2700

tcccccttcc tcgtccacca tctcatgccc ctggctctcc tgccccttcc ctacaggggt     2760

tcctggctct gctctaaggg                                                 2780


<210>  473
<211>  1787
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Donor sequence containing a Clover cassette (250ng) and homology 
       arms to the LMNA locus

<400>  473
ggcaagcttg gagccgacag tgctgagcag gcaggagcca agagagggga agcttgagcc       60

tcacgcagtt aggggtgcgc tggagagggt ggggcccgac tccgccacac cccaacggtc      120

cttccccctc ctcaccactc ccgcccccac ccccaatgga tctgggactg cccctttaag      180

agtagtggcc cctcctccct tcagaggagg acctattaga gcctttgccc cggcgtcggt      240

gactcagtgt tcgcgggagc gccgcaccta caccagccaa cccagatccc gaggtccgac      300

agcgcccggc ccagatcccc acgcctgcca ggagcaagcc gagagccagc cggccggcgc      360

actccgactc cgagcagtct ctgtccttcg acccgagccc cgcgcccttt ccgggacccc      420

tgccccgcgg gcagcgctgc caacctgccg gccatggagg tgagcaaggg cgaggagctg      480

ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc      540

agcgtccgcg gcgagggcga gggcgatgcc accaacggca agctgaccct gaagttcatc      600

tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccacctt cggctacggc      660

gtggcctgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc      720

atgcccgaag gctacgtcca ggagcgcacc atctctttca aggacgacgg tacctacaag      780

acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc      840

atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa cttcaacagc      900

cacaacgtct atatcacggc cgacaagcag aagaacggca tcaaggctaa cttcaagatc      960

cgccacaacg ttgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc     1020

atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagccatca gtccgccctg     1080

agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc     1140

gggattacac atggcatgga cgagctgtac aagaccccgt cccagcggcg cgccacccgc     1200

agcggggcgc aggccagctc cactccgctg tcgcccaccc gcatcacccg gctgcaggag     1260

aaggaggacc tgcaggagct caatgatcgc ttggcggtct acatcgaccg tgtgcgctcg     1320

ctggaaacgg agaacgcagg gctgcgcctt cgcatcaccg agtctgaaga ggtggtcagc     1380

cgcgaggtgt ccggcatcaa ggccgcctac gaggccgagc tcggggatgc ccgcaagacc     1440

cttgactcag tagccaagga gcgcgcccgc ctgcagctgg agctgagcaa agtgcgtgag     1500

gagtttaagg agctgaaagc gcggtgagtt cgcccaggtg gctgcgtgcc tggcggggag     1560

tggagagggc ggcgggccgg cgcccctggc cggccgcagg aagggagtga gagggcctgg     1620

aggccgataa ctttgccata gtctcctccc tccccggaac tgcccccagc gggtgactgg     1680

cagtgtcaag gggaattgtc aagacaggac agagagggaa gtggtggtct ctgggagagg     1740

gtcggggagg atataaggaa tggtgggggt atcagggaca agttggc                   1787


<210>  474
<211>  1555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Donor sequence HIST1H2BK

<400>  474
acaaggtgct gaagcaggtc caccccgaca ccggcatctc ctctaaggcc atgggaatca       60

tgaactcctt cgtcaacgac atcttcgaac gcatcgcggg tgaggcttcc cgcctggcgc      120

attacaacaa gcgctcgacc atcacctcca gggagatcca gacggccgtg cgcctgctgc      180

tgcccgggga gttggccaag cacgccgtgt ccgagggcac caaggccgtc accaagtaca      240

ccagcgctaa gggtaccatg gtgagcgtga tcaagcccga gatgaagatc aagctgtgca      300

tgaggggcac cgtgaacggc cacaacttcg tgatcgaggg cgagggcaag ggcaacccct      360

acgagggcac ccagatcctg gacctgaacg tgaccgaggg cgcccccctg cccttcgcct      420

acgacatcct gaccaccgtg ttccagtacg gcaacagggc cttcaccaag taccccgccg      480

acatccagga ctacttcaag cagaccttcc ccgagggcta ccactgggag aggagcatga      540

cctacgagga ccagggcatc tgcaccgcca ccagcaacat cagcatgagg ggcgactgct      600

tcttctacga catcaggttc gacggcacca acttcccccc caacggcccc gtgatgcaga      660

agaagaccct gaagtgggag cccagcaccg agaagatgta cgtggaggac ggcgtgctga      720

agggcgacgt gaacatgagg ctgctgctgg agggcggcgg ccactacagg tgcgacttca      780

agaccaccta caaggccaag aaggaggtga ggctgcccga cgcccacaag atcgaccaca      840

ggatcgagat cctgaagcac gacaaggact acaacaaggt gaagctgtac gagaacgccg      900

tggccaggta ctccatgctg cccagccagg ccaagtgatg tacaagcgtc ttaaagccca      960

accccaaagg ctcttttaag agccacttaa attatcgata ttagagctgt aaacacgtgt     1020

tcctaatcca ggcttaaatt cgggcgatct ttttaaaggg attatcatga tcttatcaca     1080

ctgagtaatg catgcagtgc ttgtaatcga gtctggctaa ggagaagcca catacacttt     1140

gttagtactg agtgaggaat atggcgccta aaaaattagg gatgtgcagg aaacttgtgt     1200

taacagaaag tgcttcctgg ctcttggcgc gaaaatggat acttccgttg tgtcgagtgc     1260

tgtgacttcc tgttagaact tgttgaaagc ctattgtgtc acgtgtactt tccaccatgt     1320

aatggcgttc taacgtgagt ttatatatta gtaaatttgg ttcccgatgg cgttccagta     1380

cgtatggctt tcgctcgagc agttacctta tttaacctct tctaggctgt acccagctct     1440

gccttgcttt gcttccccct caccccctga ttccatctct gcagcccacg ggacatcggg     1500

aagatgccag accaccaggc aggatagtct gcaagggtaa ggggaggagc acagc          1555


<210>  475
<211>  2511
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATP1A1 Donor donor sequence (TurboGFP, parallel orientation)

<400>  475
caaatttatt gatggatcaa tttaaagagt tttaatctgg gtgttatgag ttccttgggc       60

ctattgtttg cctgaaccct gtggggactg gctcatcagc agaattattc atggaggaat      120

ttgctaggtt ttaccttggc tctctagctt gggacatttt gtttcttcct taaatcctta      180

ttgcaaccgt ccagctacca ggtaggtata ttgccttgta agtgctggta cagtttgcct      240

tatttatatt ccactgcttc tcagggatta acatctgctc gtgcagctga gatcctggcg      300

cgagatggtc ccaacgccct cactccccct cccactactc ctgaatggat caagttttgt      360

cggcagctct ttggggggtt ctcaatgtta ctgtggattg gagcgattct ttgtttcttg      420

gcttatagca tcagagctgc tacagaagag gaacctcaaa acgatgacgt gagttctgta      480

attcagcata tcgatttgta gtacacatca gatagcttat atcttgtgga aaggacgaaa      540

caccggtttg gggttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg      600

ctctgggcgt ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac      660

gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct      720

tcctgctccg cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca      780

aacggaagcc gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc      840

agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgagag      900

cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt      960

cctgcccgcg cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc     1020

cctcgttgac cgaatcaccg acctctctcc ccaggggtac ccagaattga tctaccatgg     1080

actacaaaga cgatgacgac aaggtcgact ctagagctgc agagagcgac gagagcggcc     1140

tgcccgccat ggagatcgag tgccgcatca ccggcaccct gaacggcgtg gagttcgagc     1200

tggtgggcgg cggagagggc acccccgagc agggccgcat gaccaacaag atgaagagca     1260

ccaaaggcgc cctgaccttc agcccctacc tgctgagcca cgtgatgggc tacggcttct     1320

accacttcgg cacctacccc agcggctacg agaacccctt cctgcacgcc atcaacaacg     1380

gcggctacac caacacccgc atcgagaagt acgaggacgg cggcgtgctg cacgtgagct     1440

tcagctaccg ctacgaggcc ggccgcgtga tcggcgactt caaggtgatg ggcaccggct     1500

tccccgagga cagcgtgatc ttcaccgaca agatcgtccg cagcaacgcc accgtggagc     1560

acctgcaccc catgggcgat aacgatctgg atggcagctt cacccgcacc ttcagcctgc     1620

gcgacggcgg ctactacagc tccgtggtgg acagccacat gcacttcaag agcgccatcc     1680

accccagcat cctgcagaac gggggcccca tgttcgcctt ccgccgcgtg gaggaggatc     1740

acagcaacac cgagctgggc atcgtggagt accagcacgc cttcaagacc ccggatgcag     1800

atgccggtga agaatgaaga tctctgtgcc ttctagttgc cagccatctg ttgtttgccc     1860

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     1920

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     1980

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     2040

ctctatggag atctaagcta tcttctccgt ctttgtctcc cacttcttct caattaccac     2100

tcattactta atggttatga actcattact taatggttat gaacagctgt tgccttcaag     2160

gctcatccat tcttccttcg tttccatttc ctctctctac cacccacgtt gtagatgctc     2220

ttacaagtgg gatgcccacc tgcatgtgct gctgtgagca ggcagctctg ctcaggcccc     2280

ggccgccacc cactggatgg cagagcacag cgattcatgt tggcacatcc acctgtccag     2340

aaatgcttgg tggccattct tcaaaatcca caagttggtt gaaaaacaat ctttgtttta     2400

taaagcagga gaaactgatg catctagaac ctttccaaac gtccagttag tgatcaagtg     2460

ttggtgtgcc tgactccatt tctgaccctt cctgtgtggt ctttagaagg g              2511


<210>  476
<211>  2511
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATP1A1donor donor sequence  (TurboGFP, antiparallel orientation)

<400>  476
caaatttatt gatggatcaa tttaaagagt tttaatctgg gtgttatgag ttccttgggc       60

ctattgtttg cctgaaccct gtggggactg gctcatcagc agaattattc atggaggaat      120

ttgctaggtt ttaccttggc tctctagctt gggacatttt gtttcttcct taaatcctta      180

ttgcaaccgt ccagctacca ggtaggtata ttgccttgta agtgctggta cagtttgcct      240

tatttatatt ccactgcttc tcagggatta acatctgctc gtgcagctga gatcctggcg      300

cgagatggtc ccaacgccct cactccccct cccactactc ctgaatggat caagttttgt      360

cggcagctct ttggggggtt ctcaatgtta ctgtggattg gagcgattct ttgtttcttg      420

gcttatagca tcagagctgc tacagaagag gaacctcaaa acgatgacgt gagttctgta      480

attcagcata tcgatttgta gtacacatca gatagcttag atctccatag agcccaccgc      540

atccccagca tgcctgctat tgtcttccca atcctccccc ttgctgtcct gccccacccc      600

accccccaga atagaatgac acctactcag acaatgcgat gcaatttcct cattttatta      660

ggaaaggaca gtgggagtgg caccttccag ggtcaaggaa ggcacggggg aggggcaaac      720

aacagatggc tggcaactag aaggcacaga gatcttcatt cttcaccggc atctgcatcc      780

ggggtcttga aggcgtgctg gtactccacg atgcccagct cggtgttgct gtgatcctcc      840

tccacgcggc ggaaggcgaa catggggccc ccgttctgca ggatgctggg gtggatggcg      900

ctcttgaagt gcatgtggct gtccaccacg gagctgtagt agccgccgtc gcgcaggctg      960

aaggtgcggg tgaagctgcc atccagatcg ttatcgccca tggggtgcag gtgctccacg     1020

gtggcgttgc tgcggacgat cttgtcggtg aagatcacgc tgtcctcggg gaagccggtg     1080

cccatcacct tgaagtcgcc gatcacgcgg ccggcctcgt agcggtagct gaagctcacg     1140

tgcagcacgc cgccgtcctc gtacttctcg atgcgggtgt tggtgtagcc gccgttgttg     1200

atggcgtgca ggaaggggtt ctcgtagccg ctggggtagg tgccgaagtg gtagaagccg     1260

tagcccatca cgtggctcag caggtagggg ctgaaggtca gggcgccttt ggtgctcttc     1320

atcttgttgg tcatgcggcc ctgctcgggg gtgccctctc cgccgcccac cagctcgaac     1380

tccacgccgt tcagggtgcc ggtgatgcgg cactcgatct ccatggcggg caggccgctc     1440

tcgtcgctct ctgcagctct agagtcgacc ttgtcgtcat cgtctttgta gtccatggta     1500

gatcaattct gggtacccct ggggagagag gtcggtgatt cggtcaacga gggagccgac     1560

tgccgacgtg cgctccggag gcttgcagaa tgcggaacac cgcgcgggca ggaacagggc     1620

ccacactacc gccccacacc ccgcctcccg caccgcccct tcccggccgc tgctctcggc     1680

gcgccctgct gagcagccgc tattggccac agcccatcgc ggtcggcgcg ctgccattgc     1740

tccctggcgc tgtccgtctg cgagggtact agtgagacgt gcggcttccg tttgtcacgt     1800

ccggcacgcc gcgaaccgca aggaaccttc ccgacttagg ggcggagcag gaagcgtcgc     1860

cggggggccc acaagggtag cggcgaagat ccgggtgacg ctgcgaacgg acgtgaagaa     1920

tgtgcgagac ccagggtcgg cgccgctgcg tttcccggaa ccacgcccag agcagccgcg     1980

tccctgcgca aacccagggc tgccttggaa aaggcgcaac cccaaaccgg tgtttcgtcc     2040

tttccacaag atataagcta tcttctccgt ctttgtctcc cacttcttct caattaccac     2100

tcattactta atggttatga actcattact taatggttat gaacagctgt tgccttcaag     2160

gctcatccat tcttccttcg tttccatttc ctctctctac cacccacgtt gtagatgctc     2220

ttacaagtgg gatgcccacc tgcatgtgct gctgtgagca ggcagctctg ctcaggcccc     2280

ggccgccacc cactggatgg cagagcacag cgattcatgt tggcacatcc acctgtccag     2340

aaatgcttgg tggccattct tcaaaatcca caagttggtt gaaaaacaat ctttgtttta     2400

taaagcagga gaaactgatg catctagaac ctttccaaac gtccagttag tgatcaagtg     2460

ttggtgtgcc tgactccatt tctgaccctt cctgtgtggt ctttagaagg g              2511


<210>  477
<211>  2498
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA donor sequence (V1-NeonGreen) containing expression cassettes
       for green fluorescent protein flanked by homology arms for 
       targeted integration within intron 4 of ATP1A1

<400>  477
caaatttatt gatggatcaa tttaaagagt tttaatctgg gtgttatgag ttccttgggc       60

ctattgtttg cctgaaccct gtggggactg gctcatcagc agaattattc atggaggaat      120

ttgctaggtt ttaccttggc tctctagctt gggacatttt gtttcttcct taaatcctta      180

ttgcaaccgt ccagctacca ggtaggtata ttgccttgta agtgctggta cagtttgcct      240

tatttatatt ccactgcttc tcagggatta acatctgctc gtgcagctga gatcctggcg      300

cgagatggtc ccaacgccct cactccccct cccactactc ctgaatggat caagttttgt      360

cggcagctct ttggggggtt ctcaatgtta ctgtggattg gagcgattct ttgtttcttg      420

gcttatagca tcagagctgc tacagaagag gaacctcaaa acgatgacgt gagttctgta      480

attcagcata tcgatttgta gtacacatca gatagcttag atctccatag agcccaccgc      540

atccccagca tgcctgctat tgtcttccca atcctccccc ttgctgtcct gccccacccc      600

accccccaga atagaatgac acctactcag acaatgcgat gcaatttcct cattttatta      660

ggaaaggaca gtgggagtgg caccttccag ggtcaaggaa ggcacggggg aggggcaaac      720

aacagatggc tggcaactag aaggcacagg tttaaacgcg gccgctcgag ttatcacttg      780

tacagctcgt ccatgcccat cacatcggta aaggcctttt gccactcctt gaagttgagc      840

tcggtcttgg agtgcttgag ctccgtctta cggaacacgt acatcggctg gttcttcaga      900

tagttagccg ccattggctt ggcaaaggtg taggtggtcc gcgcagtgct ccggtagcgc      960

ttgccatttc cagtggtgta actccactta aaggtactga tgatggtttt gtcgttgggg     1020

taagtcttct tcgacctgca ccagtccgca gcggtcagcg agttggtcat cacaggaccg     1080

tcagcaggga aaccagtccc cttcacctgg gcctctcctt tgatgtggct tccctcgtag     1140

gtgtagcggt agttaacagt aagggaggca ccatcttcaa actgcattgt gcgatggact     1200

tggtatccgg agccatctac catagcggcc tggaaaggcg acatcccgtc agggtagggc     1260

aggtactgat ggaagccata cccgatatga gggaccagaa tccaggggga gaactggagg     1320

tcacccttgg tggacttcag gtttaactcc tcataaccat catttggatt gccggtgccc     1380

tgacccacca tgtcaaagtc cacaccgttg atggagccaa agatgtgtaa ctcatgtgtc     1440

gctgggagag aggccatgtt atcctcctcg cccttgctca ccatggtggc gatatcgtac     1500

ggatcctggg gagagaggtc ggtgattcgg tcaacgaggg agccgactgc cgacgtgcgc     1560

tccggaggct tgcagaatgc ggaacaccgc gcgggcagga acagggccca cactaccgcc     1620

ccacaccccg cctcccgcac cgccccttcc cggccgctgc tctcggcgcg ccctgctgag     1680

cagccgctat tggccacagc ccatcgcggt cggcgcgctg ccattgctcc ctggcgctgt     1740

ccgtctgcga gggtactagt gagacgtgcg gcttccgttt gtcacgtccg gcacgccgcg     1800

aaccgcaagg aaccttcccg acttaggggc ggagcaggaa gcgtcgccgg ggggcccaca     1860

agggtagcgg cgaagatccg ggtgacgctg cgaacggacg tgaagaatgt gcgagaccca     1920

gggtcggcgc cgctgcgttt cccggaacca cgcccagagc agccgcgtcc ctgcgcaaac     1980

ccagggctgc cttggaaaag gcgcaacccc aaaccggtgt ttcgtccttt ccacaagata     2040

taagctatct tctccgtctt tgtctcccac ttcttctcaa ttaccactca ttacttaatg     2100

gttatgaact cattacttaa tggttatgaa cagctgttgc cttcaaggct catccattct     2160

tccttcgttt ccatttcctc tctctaccac ccacgttgta gatgctctta caagtgggat     2220

gcccacctgc atgtgctgct gtgagcaggc agctctgctc aggccccggc cgccacccac     2280

tggatggcag agcacagcga ttcatgttgg cacatccacc tgtccagaaa tgcttggtgg     2340

ccattcttca aaatccacaa gttggttgaa aaacaatctt tgttttataa agcaggagaa     2400

actgatgcat ctagaacctt tccaaacgtc cagttagtga tcaagtgttg gtgtgcctga     2460

ctccatttct gacccttcct gtgtggtctt tagaaggg                             2498


<210>  478
<211>  2472
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA donor sequence (V2-NeonGreen) containing expression cassettes
       for green fluorescent protein flanked by homology arms for 
       targeted integration within intron 4 of ATP1A

<400>  478
caaatttatt gatggatcaa tttaaagagt tttaatctgg gtgttatgag ttccttgggc       60

ctattgtttg cctgaaccct gtggggactg gctcatcagc agaattattc atggaggaat      120

ttgctaggtt ttaccttggc tctctagctt gggacatttt gtttcttcct taaatcctta      180

ttgcaaccgt ccagctacca ggtaggtata ttgccttgta agtgctggta cagtttgcct      240

tatttatatt ccactgcttc tcagggatta acatctgctc gtgcagctga gatcctggcg      300

cgagatggtc ccaacgccct cactccccct cccactactc ctgaatggat caagttttgt      360

cggcagctct ttggggggtt ctcaatgtta ctgtggattg gagcgattct ttgtttcttg      420

gcttatagca tcagagctgc tacagaagag gaacctcaaa acgatgacgt gagttctgta      480

attcagcata tcggatctcc atagagccca ccgcatcccc agcatgcctg ctattgtctt      540

cccaatcctc ccccttgctg tcctgcccca ccccaccccc cagaatagaa tgacacctac      600

tcagacaatg cgatgcaatt tcctcatttt attaggaaag gacagtggga gtggcacctt      660

ccagggtcaa ggaaggcacg ggggaggggc aaacaacaga tggctggcaa ctagaaggca      720

caggtttaaa cgcggccgct cgagttatca cttgtacagc tcgtccatgc ccatcacatc      780

ggtaaaggcc ttttgccact ccttgaagtt gagctcggtc ttggagtgct tgagctccgt      840

cttacggaac acgtacatcg gctggttctt cagatagtta gccgccattg gcttggcaaa      900

ggtgtaggtg gtccgcgcag tgctccggta gcgcttgcca tttccagtgg tgtaactcca      960

cttaaaggta ctgatgatgg ttttgtcgtt ggggtaagtc ttcttcgacc tgcaccagtc     1020

cgcagcggtc agcgagttgg tcatcacagg accgtcagca gggaaaccag tccccttcac     1080

ctgggcctct cctttgatgt ggcttccctc gtaggtgtag cggtagttaa cagtaaggga     1140

ggcaccatct tcaaactgca ttgtgcgatg gacttggtat ccggagccat ctaccatagc     1200

ggcctggaaa ggcgacatcc cgtcagggta gggcaggtac tgatggaagc catacccgat     1260

atgagggacc agaatccagg gggagaactg gaggtcaccc ttggtggact tcaggtttaa     1320

ctcctcataa ccatcatttg gattgccggt gccctgaccc accatgtcaa agtccacacc     1380

gttgatggag ccaaagatgt gtaactcatg tgtcgctggg agagaggcca tgttatcctc     1440

ctcgcccttg ctcaccatgg tggcgatatc gtacggatcc tggggagaga ggtcggtgat     1500

tcggtcaacg agggagccga ctgccgacgt gcgctccgga ggcttgcaga atgcggaaca     1560

ccgcgcgggc aggaacaggg cccacactac cgccccacac cccgcctccc gcaccgcccc     1620

ttcccggccg ctgctctcgg cgcgccctgc tgagcagccg ctattggcca cagcccatcg     1680

cggtcggcgc gctgccattg ctccctggcg ctgtccgtct gcgagggtac tagtgagacg     1740

tgcggcttcc gtttgtcacg tccggcacgc cgcgaaccgc aaggaacctt cccgacttag     1800

gggcggagca ggaagcgtcg ccggggggcc cacaagggta gcggcgaaga tccgggtgac     1860

gctgcgaacg gacgtgaaga atgtgcgaga cccagggtcg gcgccgctgc gtttcccgga     1920

accacgccca gagcagccgc gtccctgcgc aaacccaggg ctgccttgga aaaggcgcaa     1980

ccccaaaccg gtgtttcgtc ctttccacaa gatataagct atcttctccg tctttgtctc     2040

ccacttcttc tcaattacca ctcattactt aatggttatg aactcattac ttaatggtta     2100

tgaacagctg ttgccttcaa ggctcatcca ttcttccttc gtttccattt cctctctcta     2160

ccacccacgt tgtagatgct cttacaagtg ggatgcccac ctgcatgtgc tgctgtgagc     2220

aggcagctct gctcaggccc cggccgccac ccactggatg gcagagcaca gcgattcatg     2280

ttggcacatc cacctgtcca gaaatgcttg gtggccattc ttcaaaatcc acaagttggt     2340

tgaaaaacaa tctttgtttt ataaagcagg agaaactgat gcatctagaa cctttccaaa     2400

cgtccagtta gtgatcaagt gttggtgtgc ctgactccat ttctgaccct tcctgtgtgg     2460

tctttagaag gg                                                         2472


<210>  479
<211>  1763
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA donor sequence (LMNA-mScarlet)

<400>  479
ggcaagcttg gagccgacag tgctgagcag gcaggagcca agagagggga agcttgagcc       60

tcacgcagtt aggggtgcgc tggagagggt ggggcccgac tccgccacac cccaacggtc      120

cttccccctc ctcaccactc ccgcccccac ccccaatgga tctgggactg cccctttaag      180

agtagtggcc cctcctccct tcagaggagg acctattaga gcctttgccc cggcgtcggt      240

gactcagtgt tcgcgggagc gccgcaccta caccagccaa cccagatccc gaggtccgac      300

agcgcccggc ccagatcccc acgcctgcca ggagcaagcc gagagccagc cggccggcgc      360

actccgactc cgagcagtct ctgtccttcg acccgagccc cgcgcccttt ccgggacccc      420

tgccccgcgg gcagcgctgc caacctgccg gccatggtga gcaagggcga ggcagtgatc      480

aaggagttca tgcggttcaa ggtgcacatg gagggctcca tgaacggcca cgagttcgag      540

atcgagggcg agggcgaggg ccgcccctac gagggcaccc agaccgccaa gctgaaggtg      600

accaagggtg gccccctgcc cttctcctgg gacatcctgt cccctcagtt catgtacggc      660

tccagggcct tcatcaagca ccccgccgac atccccgact actataagca gtccttcccc      720

gagggcttca agtgggagcg cgtgatgaac ttcgaggacg gcggcgccgt gaccgtgacc      780

caggacacct ccctggagga cggcaccctg atctacaagg tgaagctccg cggcaccaac      840

ttccctcctg acggccccgt aatgcagaag aagacaatgg gctgggaagc atccaccgag      900

cggttgtacc ccgaggacgg cgtgctgaag ggcgacatta agatggccct gcgcctgaag      960

gacggcggcc gctacctggc ggacttcaag accacctaca aggccaagaa gcccgtgcag     1020

atgcccggcg cctacaacgt cgaccgcaag ttggacatca cctcccacaa cgaggactac     1080

accgtggtgg aacagtacga acgctccgag ggccgccact ccaccggcgg catggacgag     1140

ctgtacaaga ccccgtccca gcggcgcgcc acccgcagcg gggcgcaggc cagctccact     1200

ccgctgtcgc ccacccgcat cacccggctg caggagaagg aggacctgca ggagctcaat     1260

gatcgcttgg cggtctacat cgaccgtgtg cgctcgctgg aaacggagaa cgcagggctg     1320

cgccttcgca tcaccgagtc tgaagaggtg gtcagccgcg aggtgtccgg catcaaggcc     1380

gcctacgagg ccgagctcgg ggatgcccgc aagacccttg actcagtagc caaggagcgc     1440

gcccgcctgc agctggagct gagcaaagtg cgtgaggagt ttaaggagct gaaagcgcgg     1500

tgagttcgcc caggtggctg cgtgcctggc ggggagtgga gagggcggcg ggccggcgcc     1560

cctggccggc cgcaggaagg gagtgagagg gcctggaggc cgataacttt gccatagtct     1620

cctccctccc cggaactgcc cccagcgggt gactggcagt gtcaagggga attgtcaaga     1680

caggacagag agggaagtgg tggtctctgg gagagggtcg gggaggatat aaggaatggt     1740

gggggtatca gggacaagtt ggc                                             1763


<210>  480
<211>  2259
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA donor sequence for HPRT (PGK-EGFP)

<400>  480
ccagtctgat aggtgaaaat ggtatcttgt ttttatttgc atttaaaaaa aattatgata       60

gtggtatgct tggttttttt gaaggtatca aattttttac cttatgaaac atgagggcaa      120

aggatgtgtt acgtggaaga tttaaaaaaa atttttaatg catttttttg agacaaggtc      180

ttgctctatt gtccaggctg gagtgcagtg gcacaatcac agttcactcc agcctcaaca      240

tcctgcacta aagtgatttt cccacctcac ctctcaagta gctgggacta caggtacatg      300

ctaccatgcc tggctaattt tttttttttt gcaggcatgg ggtctcacta tattgcccag      360

gttggtgtgg aagtttaatg actaagaggt gtttgttata aagtttaatg tatgaaactt      420

tctattaaat tcctgatttt atttctgtag gactgaacgt cttgctcgag aggaagcttc      480

cacggggttg gggttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg      540

ctctgggcgt ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac      600

gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct      660

tcctgctccg cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca      720

aacggaagcc gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc      780

agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgagag      840

cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt      900

cctgcccgcg cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc      960

cctcgttgac cgaatcaccg acctctctcc ccagggggat ccaccggtcg ccaccatggt     1020

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga     1080

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa     1140

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt     1200

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca     1260

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     1320

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     1380

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     1440

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat     1500

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca     1560

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     1620

gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     1680

ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca agtaaagcgg     1740

ccgcgtcgag tctagagggc ccgtttaaac ccgctgatca gcctcgactg tgccttctag     1800

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     1860

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     1920

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     1980

caggcatgct ggggatgcgg tgggctctat ggaagctatc cgatgaagga gatgggaggc     2040

catcacattg tagccctctg tgtgctcaag gggggctata aattctttgc tgacctgctg     2100

gattacatca aagcactgaa tagaaatagt gatagatcca ttcctatgac tgtagatttt     2160

atcagactga agagctattg tgtgagtata tttaatatat gattcttttt agtggcaaca     2220

gtaggttttc ttatattttc tttgaatctc tgcaaacca                            2259


<210>  481
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  481
atgctgggac agcccgcgcc cctagaacgc tttgcgtccc gacgcccgca ggtcctcgcg       60

gtgcgcaccg tttgcgactt ggtacttgga aaaatggaca aggattgtga aatgaaacgc      120

accacactgg acagcccttt ggggaagctg gagctgtctg gttgtgagca gggtctgcac      180

gaaataaagc tcctgggcaa ggggacgtct gcagctgatg ccgtggaggt cccagccccc      240

gctgcggttc tcggaggtcc ggagcccctg atgcagtgca cagcctggct gaatgcctat      300

ttccaccagc ccgaggctat cgaagagttc cccgtgccgg ctcttcacca tcccgttttc      360

cagcaagagt cgttcaccag acaggtgtta tggaagctgc tgaaggttgt gaaattcgga      420

gaagtgattt cttaccagca attagcagcc ctggcaggca accccaaagc cgcgcgagca      480

gtgggaggag caatgagagg caatcctgtc cccatcctca tcccgtgcca cagagtggtc      540

tgcagcagcg gagccgtggg caactactcc ggaggactgg ccgtgaagga atggcttctg      600

gcccatgaag gccaccggtt ggggaagcca ggcttgggag ggagctcagg tctggcaggg      660

gcctggctca agggagcggg agctacctcg ggctccccgc ctgctggccg aaactga         717


<210>  482
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Leu Gly Gln Pro Ala Pro Leu Glu Arg Phe Ala Ser Arg Arg Pro 
1               5                   10                  15      


Gln Val Leu Ala Val Arg Thr Val Cys Asp Leu Val Leu Gly Lys Met 
            20                  25                  30          


Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu Gly 
        35                  40                  45              


Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys Leu 
    50                  55                  60                  


Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala Pro 
65                  70                  75                  80  


Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Cys Thr Ala Trp 
                85                  90                  95      


Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro Val 
            100                 105                 110         


Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg Gln 
        115                 120                 125             


Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile Ser 
    130                 135                 140                 


Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Lys Ala Ala Arg Ala 
145                 150                 155                 160 


Val Gly Gly Ala Met Arg Gly Asn Pro Val Pro Ile Leu Ile Pro Cys 
                165                 170                 175     


His Arg Val Val Cys Ser Ser Gly Ala Val Gly Asn Tyr Ser Gly Gly 
            180                 185                 190         


Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu Gly 
        195                 200                 205             


Lys Pro Gly Leu Gly Gly Ser Ser Gly Leu Ala Gly Ala Trp Leu Lys 
    210                 215                 220                 


Gly Ala Gly Ala Thr Ser Gly Ser Pro Pro Ala Gly Arg Asn 
225                 230                 235             


<210>  483
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  483
actgacagtg gctgcccccc tgtcttccag gtccccatcc tcatcccgtg ccacagagtg       60

gtctgcagca gcggagccgt gggcaactac                                        90


<210>  484
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide (ssODN) of MGMT

<400>  484
actgacagtg gctgcccccc tgtcctccag gtcaagatcc tcatcccgtg ccacagagtg       60

gtctgcagca gcggagccgt ggccaactac                                        90


<210>  485
<211>  1020
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (117)..(124)
<223>  X is any amino acid or is absent

<400>  485

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  486
<211>  1013
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (109)..(116)
<223>  X is any amino acid or is absent

<400>  486

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
225                 230                 235                 240 


Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                245                 250                 255     


Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                325                 330                 335     


Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
        355                 360                 365             


Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
        595                 600                 605             


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Thr Tyr Tyr 
    1010             


<210>  487
<211>  1029
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (127)..(134)
<223>  Xaa can be any naturally occurring amino acid

<400>  487

Met Gly Leu Trp Gly Lys Lys Gly Thr Val Ala Pro His Asp Gln Ser 
1               5                   10                  15      


Pro Arg Arg Arg Pro Lys Lys Gly Leu Ile Lys Lys Lys Met Val Lys 
            20                  25                  30          


Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys Glu Val Val 
        35                  40                  45              


Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr Lys Tyr Ser 
    50                  55                  60                  


Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys Glu Ile Leu 
65                  70                  75                  80  


Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr Thr Pro Glu 
                85                  90                  95      


Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile Gln Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Lys Asp Asn Leu Tyr Leu Ser Ile Val Leu 
    130                 135                 140                 


Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
145                 150                 155                 160 


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
                165                 170                 175     


Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn Val Gln Glu 
            180                 185                 190         


Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
        195                 200                 205             


Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val Asp Asn Ser 
    210                 215                 220                 


Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro Asp Phe Thr 
225                 230                 235                 240 


His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn 
                245                 250                 255     


Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Ser 
            260                 265                 270         


Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu Ala Val Gly 
        275                 280                 285             


Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Leu Ile Thr 
    290                 295                 300                 


Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile Gly Ile Ile 
                325                 330                 335     


Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu 
            340                 345                 350         


Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn 
        355                 360                 365             


Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp 
385                 390                 395                 400 


Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu Gln Thr Gly 
                405                 410                 415     


Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu Ala Arg Ile 
            420                 425                 430         


Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln Glu Ile Leu 
        435                 440                 445             


Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu Ser Ala Leu 
    450                 455                 460                 


Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu Met Arg Glu 
465                 470                 475                 480 


Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr 
                485                 490                 495     


Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr His Val Leu 
            500                 505                 510         


Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys Ser Thr Phe 
        515                 520                 525             


Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met Lys Glu Ala 
    530                 535                 540                 


Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu 
545                 550                 555                 560 


Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys Gly Phe Pro 
                565                 570                 575     


Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu Cys Phe Val 
            580                 585                 590         


Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
        595                 600                 605             


Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
    610                 615                 620                 


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
625                 630                 635                 640 


Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg Leu Lys Ile 
                645                 650                 655     


Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile Val Val His 
            660                 665                 670         


Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp Gln Ile Leu 
        675                 680                 685             


Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
    690                 695                 700                 


Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val Val Ala Val 
705                 710                 715                 720 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
                725                 730                 735     


Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala Ala 
            740                 745                 750         


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
        755                 760                 765             


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Met Tyr 
    770                 775                 780                 


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Met Phe Ile 
785                 790                 795                 800 


Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
                805                 810                 815     


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ser 
            820                 825                 830         


Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro Lys Thr Asp 
        835                 840                 845             


Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly Gln Ile Gly 
    850                 855                 860                 


Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
                885                 890                 895     


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
            900                 905                 910         


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
        915                 920                 925             


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
    930                 935                 940                 


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
945                 950                 955                 960 


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
                965                 970                 975     


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
            980                 985                 990         


Trp Trp Leu Cys Ala Ile Pro Tyr  Ser Ile Leu Ile Phe  Val Tyr Asp 
        995                 1000                 1005             


Glu Ile  Arg Lys Leu Leu Ile  Arg Gln His Pro Asp  Gly Trp Val 
    1010                 1015                 1020             


Glu Arg  Glu Thr Tyr Tyr 
    1025                 


