                         SEQUENCE LISTING

<110>  Lim, Wendell  A.
       Roybal, Kole  T.
       Williams, Jasper  Z.
 
<120>  Proteolytically Cleavable Chimeric Polypeptides and Methods of 
       Use Thereof

<130>  UCSF-544WO

<150>  US 62/378,614
<151>  2016-08-23

<160>  134   

<170>  PatentIn version 3.5

<210>  1
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  2
<211>  2531
<212>  PRT
<213>  Mus musculus

<400>  2

Met Pro Arg Leu Leu Thr Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Ser Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp His Gly 
65                  70                  75                  80  


Gly Thr Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Ala Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
145                 150                 155                 160 


Ser Tyr Ile Cys Arg Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly His Cys Met Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Gln Cys Pro Lys Gly Phe Asn Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ser 
    610                 615                 620                 


Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                885                 890                 895     


Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asn Pro Cys Gln Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Val Gly Phe Asn 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln Tyr  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Arg Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Ser Tyr  Gly Thr Tyr Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Leu Asn  Cys Gln Asn Leu Val  Arg Trp Cys Asp Ser  Ala Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Arg Cys Trp  Gln Thr Asn Thr Gln  Tyr His Cys 
    1070                 1075                 1080             


Glu Cys  Arg Ser Gly Trp Thr  Gly Val Asn Cys Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Lys Arg Gly Ile  Asp Val Thr 
    1100                 1105                 1110             


Leu Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Glu  Gly Asp Lys 
    1115                 1120                 1125             


His Tyr  Cys His Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Glu  Val Asp Glu Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Phe Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Ser Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Ile Asp  Leu Thr Asn 
    1190                 1195                 1200             


Ser Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  His Pro Pro Leu Asp  Pro Ala Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Thr Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Pro 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Arg Gly Lys Pro  Cys Lys Asn Gly Gly  Val Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Arg  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Ser Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Val Gly Ser Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Asn Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Thr Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Gln Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Val Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Asn Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Leu Thr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Leu Val Val 
    1565                 1570                 1575             


Leu Leu  Pro Pro Asp Gln Leu  Arg Asn Asn Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser His Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  Gln Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly His Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ser Thr  Val Gly Trp 
    1625                 1630                 1635             


Ala Thr  Ser Ser Leu Leu Pro  Gly Thr Ser Gly Gly  Arg Gln Arg 
    1640                 1645                 1650             


Arg Glu  Leu Asp Pro Met Asp  Ile Arg Gly Ser Ile  Val Tyr Leu 
    1655                 1660                 1665             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Ser Ser Ser  Gln Cys Phe 
    1670                 1675                 1680             


Gln Ser  Ala Thr Asp Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser 
    1685                 1690                 1695             


Leu Gly  Ser Leu Asn Ile Pro  Tyr Lys Ile Glu Ala  Val Lys Ser 
    1700                 1705                 1710             


Glu Pro  Val Glu Pro Pro Leu  Pro Ser Gln Leu His  Leu Met Tyr 
    1715                 1720                 1725             


Val Ala  Ala Ala Ala Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly 
    1730                 1735                 1740             


Val Leu  Leu Ser Arg Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp 
    1745                 1750                 1755             


Phe Pro  Glu Gly Phe Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg 
    1760                 1765                 1770             


Arg Glu  Pro Leu Gly Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys 
    1775                 1780                 1785             


Asn Ala  Ser Asp Gly Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp 
    1790                 1795                 1800             


Gly Asp  Glu Asp Leu Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro 
    1805                 1810                 1815             


Val Val  Leu Pro Asp Leu Ser  Asp Gln Thr Asp His  Arg Gln Trp 
    1820                 1825                 1830             


Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met 
    1835                 1840                 1845             


Ala Pro  Thr Pro Pro Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp 
    1850                 1855                 1860             


Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala 
    1865                 1870                 1875             


Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu 
    1880                 1885                 1890             


Glu Asp  Ala Pro Ala Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala 
    1895                 1900                 1905             


Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His 
    1910                 1915                 1920             


Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu 
    1925                 1930                 1935             


Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr 
    1940                 1945                 1950             


Pro Leu  His Ala Ala Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln 
    1955                 1960                 1965             


Ile Leu  Leu Arg Asn Arg Ala  Thr Asp Leu Asp Ala  Arg Met His 
    1970                 1975                 1980             


Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu 
    1985                 1990                 1995             


Gly Met  Leu Glu Asp Leu Ile  Asn Ser His Ala Asp  Val Asn Ala 
    2000                 2005                 2010             


Val Asp  Asp Leu Gly Lys Ser  Ala Leu His Trp Ala  Ala Ala Val 
    2015                 2020                 2025             


Asn Asn  Val Asp Ala Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn 
    2030                 2035                 2040             


Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr Pro Leu  Phe Leu Ala 
    2045                 2050                 2055             


Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His 
    2060                 2065                 2070             


Phe Ala  Asn Arg Asp Ile Thr  Asp His Met Asp Arg  Leu Pro Arg 
    2075                 2080                 2085             


Asp Ile  Ala Gln Glu Arg Met  His His Asp Ile Val  Arg Leu Leu 
    2090                 2095                 2100             


Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Gln Leu His  Gly Thr Ala 
    2105                 2110                 2115             


Leu Gly  Gly Thr Pro Thr Leu  Ser Pro Thr Leu Cys  Ser Pro Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Gly Asn Leu Lys  Ser Ala Thr Gln Gly  Lys Lys Ala 
    2135                 2140                 2145             


Arg Lys  Pro Ser Thr Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala 
    2150                 2155                 2160             


Lys Asp  Leu Lys Ala Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly 
    2165                 2170                 2175             


Cys Leu  Leu Asp Ser Ser Ser  Met Leu Ser Pro Val  Asp Ser Leu 
    2180                 2185                 2190             


Glu Ser  Pro His Gly Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu 
    2195                 2200                 2205             


Leu Pro  Ser Pro Phe Gln Gln  Ser Pro Ser Met Pro  Leu Ser His 
    2210                 2215                 2220             


Leu Pro  Gly Met Pro Asp Thr  His Leu Gly Ile Ser  His Leu Asn 
    2225                 2230                 2235             


Val Ala  Ala Lys Pro Glu Met  Ala Ala Leu Ala Gly  Gly Ser Arg 
    2240                 2245                 2250             


Leu Ala  Phe Glu Pro Pro Pro  Pro Arg Leu Ser His  Leu Pro Val 
    2255                 2260                 2265             


Ala Ser  Ser Ala Ser Thr Val  Leu Ser Thr Asn Gly  Thr Gly Ala 
    2270                 2275                 2280             


Met Asn  Phe Thr Val Gly Ala  Pro Ala Ser Leu Asn  Gly Gln Cys 
    2285                 2290                 2295             


Glu Trp  Leu Pro Arg Leu Gln  Asn Gly Met Val Pro  Ser Gln Tyr 
    2300                 2305                 2310             


Asn Pro  Leu Arg Pro Gly Val  Thr Pro Gly Thr Leu  Ser Thr Gln 
    2315                 2320                 2325             


Ala Ala  Gly Leu Gln His Ser  Met Met Gly Pro Leu  His Ser Ser 
    2330                 2335                 2340             


Leu Ser  Thr Asn Thr Leu Ser  Pro Ile Ile Tyr Gln  Gly Leu Pro 
    2345                 2350                 2355             


Asn Thr  Arg Leu Ala Thr Gln  Pro His Leu Val Gln  Thr Gln Gln 
    2360                 2365                 2370             


Val Gln  Pro Gln Asn Leu Gln  Leu Gln Pro Gln Asn  Leu Gln Pro 
    2375                 2380                 2385             


Pro Ser  Gln Pro His Leu Ser  Val Ser Ser Ala Ala  Asn Gly His 
    2390                 2395                 2400             


Leu Gly  Arg Ser Phe Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val 
    2405                 2410                 2415             


Gln Pro  Leu Gly Pro Ser Ser  Leu Pro Val His Thr  Ile Leu Pro 
    2420                 2425                 2430             


Gln Glu  Ser Gln Ala Leu Pro  Thr Ser Leu Pro Ser  Ser Met Val 
    2435                 2440                 2445             


Pro Pro  Met Thr Thr Thr Gln  Phe Leu Thr Pro Pro  Ser Gln His 
    2450                 2455                 2460             


Ser Tyr  Ser Ser Ser Pro Val  Asp Asn Thr Pro Ser  His Gln Leu 
    2465                 2470                 2475             


Gln Val  Pro Glu His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2480                 2485                 2490             


Asp Gln  Trp Ser Ser Ser Ser  Pro His Ser Asn Ile  Ser Asp Trp 
    2495                 2500                 2505             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Thr Met Pro  Ser Gln Ile 
    2510                 2515                 2520             


Thr His  Ile Pro Glu Ala Phe  Lys 
    2525                 2530     


<210>  3
<211>  1429
<212>  PRT
<213>  Caenorhabditis elegans

<400>  3

Met Arg Ile Pro Thr Ile Cys Phe Leu Phe Leu Leu Ile Ser Leu Ser 
1               5                   10                  15      


Lys Ser Leu His Ile Gly Ser Cys Leu Gly Leu Ile Cys Gly Arg Asn 
            20                  25                  30          


Gly His Cys His Ala Gly Pro Val Asn Gly Thr Gln Thr Ser Tyr Trp 
        35                  40                  45              


Cys Arg Cys Asp Glu Gly Phe Gly Gly Glu Tyr Cys Glu Gln Gln Cys 
    50                  55                  60                  


Asp Val Ser Lys Cys Gly Ala Asp Glu Lys Cys Val Phe Asp Lys Asp 
65                  70                  75                  80  


Tyr Arg Met Glu Thr Cys Val Cys Lys Asp Cys Asp Ile Asn Gly Asn 
                85                  90                  95      


Ser Leu Leu Lys Pro Ser Cys Pro Ser Gly Tyr Gly Gly Asp Asp Cys 
            100                 105                 110         


Lys Thr Gln Gly Trp Cys Tyr Pro Ser Val Cys Met Asn Gly Gly Gln 
        115                 120                 125             


Cys Ile Gly Ala Gly Asn Arg Ala Lys Cys Ala Cys Pro Asp Gly Phe 
    130                 135                 140                 


Lys Gly Glu Arg Cys Glu Leu Asp Val Asn Glu Cys Glu Glu Asn Lys 
145                 150                 155                 160 


Asn Ala Cys Gly Asn Arg Ser Thr Cys Met Asn Thr Leu Gly Thr Tyr 
                165                 170                 175     


Ile Cys Val Cys Pro Gln Gly Phe Leu Pro Pro Asp Cys Leu Lys Pro 
            180                 185                 190         


Gly Asn Thr Ser Thr Val Glu Phe Lys Gln Pro Val Cys Phe Leu Glu 
        195                 200                 205             


Ile Ser Ala Asp His Pro Asp Gly Arg Ser Met Tyr Cys Gln Asn Gly 
    210                 215                 220                 


Gly Phe Cys Asp Lys Ala Ser Ser Lys Cys Gln Cys Pro Pro Gly Tyr 
225                 230                 235                 240 


His Gly Ser Thr Cys Glu Leu Leu Glu Lys Glu Asp Ser Cys Ala Ser 
                245                 250                 255     


Asn Pro Cys Ser His Gly Val Cys Ile Ser Phe Ser Gly Gly Phe Gln 
            260                 265                 270         


Cys Ile Cys Asp Asp Gly Tyr Ser Gly Ser Tyr Cys Gln Glu Gly Lys 
        275                 280                 285             


Asp Asn Cys Val Asn Asn Lys Cys Glu Ala Gly Ser Lys Cys Ile Asn 
    290                 295                 300                 


Gly Val Asn Ser Tyr Phe Cys Asp Cys Pro Pro Glu Arg Thr Gly Pro 
305                 310                 315                 320 


Tyr Cys Glu Lys Met Asp Cys Ser Ala Ile Pro Asp Ile Cys Asn His 
                325                 330                 335     


Gly Thr Cys Ile Asp Ser Pro Leu Ser Glu Lys Ala Phe Glu Cys Gln 
            340                 345                 350         


Cys Glu Pro Gly Tyr Glu Gly Ile Leu Cys Glu Gln Asp Lys Asn Glu 
        355                 360                 365             


Cys Leu Ser Glu Asn Met Cys Leu Asn Asn Gly Thr Cys Val Asn Leu 
    370                 375                 380                 


Pro Gly Ser Phe Arg Cys Asp Cys Ala Arg Gly Phe Gly Gly Lys Trp 
385                 390                 395                 400 


Cys Asp Glu Pro Leu Asn Met Cys Gln Asp Phe His Cys Glu Asn Asp 
                405                 410                 415     


Gly Thr Cys Met His Thr Ser Asp His Ser Pro Val Cys Gln Cys Lys 
            420                 425                 430         


Asn Gly Phe Ile Gly Lys Arg Cys Glu Lys Glu Cys Pro Ile Gly Phe 
        435                 440                 445             


Gly Gly Val Arg Cys Asp Leu Arg Leu Glu Ile Gly Ile Cys Ser Arg 
    450                 455                 460                 


Gln Gly Gly Lys Cys Phe Asn Gly Gly Lys Cys Leu Ser Gly Phe Cys 
465                 470                 475                 480 


Val Cys Pro Pro Asp Phe Thr Gly Asn Gln Cys Glu Val Asn Arg Lys 
                485                 490                 495     


Asn Gly Lys Ser Ser Leu Ser Glu Asn Leu Cys Leu Ser Asp Pro Cys 
            500                 505                 510         


Met Asn Asn Ala Thr Cys Ile Asp Val Asp Ala His Ile Gly Tyr Ala 
        515                 520                 525             


Cys Ile Cys Lys Gln Gly Phe Glu Gly Asp Ile Cys Glu Arg His Lys 
    530                 535                 540                 


Asp Leu Cys Leu Glu Asn Pro Cys Ser Asn Gly Gly Val Cys His Gln 
545                 550                 555                 560 


His Arg Glu Ser Phe Ser Cys Asp Cys Pro Pro Gly Phe Tyr Gly Asn 
                565                 570                 575     


Gly Cys Glu Gln Glu Lys Met Phe Arg Cys Leu Lys Ser Thr Cys Gln 
            580                 585                 590         


Asn Gly Gly Val Cys Ile Asn Glu Glu Glu Lys Gly Arg Lys Cys Glu 
        595                 600                 605             


Cys Ser Tyr Gly Phe Ser Gly Ala Arg Cys Glu Glu Lys Ile Asn Leu 
    610                 615                 620                 


Thr Gly Phe Thr Glu Lys Asp Ser Leu Leu Arg Ser Val Cys Glu Lys 
625                 630                 635                 640 


Arg Lys Cys Ser Glu Arg Ala Asn Asp Gly Asn Cys Asp Ala Asp Cys 
                645                 650                 655     


Asn Tyr Ala Ala Cys Lys Phe Asp Gly Gly Asp Cys Ser Gly Lys Arg 
            660                 665                 670         


Glu Pro Phe Ser Lys Cys Arg Tyr Gly Asn Met Cys Ala Asp Phe Phe 
        675                 680                 685             


Ala Asn Gly Val Cys Asn Gln Ala Cys Asn Asn Glu Glu Cys Leu Tyr 
    690                 695                 700                 


Asp Gly Met Asp Cys Leu Pro Ala Val Val Arg Cys Pro Val Lys Ile 
705                 710                 715                 720 


Arg Glu His Cys Ala Ser Arg Phe Ala Asn Gly Ile Cys Asp Pro Glu 
                725                 730                 735     


Cys Asn Thr Asn Gly Cys Gly Phe Asp Gly Gly Asp Cys Asp Asn Glu 
            740                 745                 750         


Thr Asn Ala Thr Ile Ile Thr Asn Ile Arg Ile Thr Val Gln Met Asp 
        755                 760                 765             


Pro Lys Glu Phe Gln Val Thr Gly Gly Gln Ser Leu Met Glu Ile Ser 
    770                 775                 780                 


Ser Ala Leu Arg Val Thr Val Arg Ile Gln Arg Asp Glu Glu Gly Pro 
785                 790                 795                 800 


Leu Val Phe Gln Trp Asn Gly Glu Ser Glu Met Asp Arg Val Lys Met 
                805                 810                 815     


Asn Glu Arg Gln Leu Thr Glu Gln His Val Leu Ser Thr Ser Ile Ser 
            820                 825                 830         


Arg Lys Ile Lys Arg Ser Ala Thr Asn Ile Gly Val Val Val Tyr Leu 
        835                 840                 845             


Glu Val Gln Glu Asn Cys Asp Thr Gly Lys Cys Leu Tyr Lys Asp Ala 
    850                 855                 860                 


Gln Ser Val Val Asp Ser Ile Ser Ala Arg Leu Ala Lys Lys Gly Ile 
865                 870                 875                 880 


Asp Ser Phe Gly Ile Pro Ile Ser Glu Ala Leu Val Ala Glu Pro Arg 
                885                 890                 895     


Lys Ser Gly Asn Asn Thr Gly Phe Leu Ser Trp Asn Ala Leu Leu Leu 
            900                 905                 910         


Ile Gly Ala Gly Cys Leu Ile Val Met Val Val Leu Met Leu Gly Ala 
        915                 920                 925             


Leu Pro Gly Asn Arg Thr Arg Lys Arg Arg Met Ile Asn Ala Ser Val 
    930                 935                 940                 


Trp Met Pro Pro Met Glu Asn Glu Glu Lys Asn Arg Lys Asn His Gln 
945                 950                 955                 960 


Ser Ile Thr Ser Ser Gln His Ser Leu Leu Glu Ala Ser Tyr Asp Gly 
                965                 970                 975     


Tyr Ile Lys Arg Gln Arg Asn Glu Leu Gln His Tyr Ser Leu Tyr Pro 
            980                 985                 990         


Asn Pro Gln Gly Tyr Gly Asn Gly  Asn Asp Phe Leu Gly  Asp Phe Asn 
        995                 1000                 1005             


His Thr  Asn Leu Gln Ile Pro  Thr Glu Pro Glu Pro  Glu Ser Pro 
    1010                 1015                 1020             


Ile Lys  Leu His Thr Glu Ala  Ala Gly Ser Tyr Ala  Ile Thr Glu 
    1025                 1030                 1035             


Pro Ile  Thr Arg Glu Ser Val  Asn Ile Ile Asp Pro  Arg His Asn 
    1040                 1045                 1050             


Arg Thr  Val Leu His Trp Ile  Ala Ser Asn Ser Ser  Ala Glu Lys 
    1055                 1060                 1065             


Ser Glu  Asp Leu Ile Val His  Glu Ala Lys Glu Cys  Ile Ala Ala 
    1070                 1075                 1080             


Gly Ala  Asp Val Asn Ala Met  Asp Cys Asp Glu Asn  Thr Pro Leu 
    1085                 1090                 1095             


Met Leu  Ala Val Leu Ala Arg  Arg Arg Arg Leu Val  Ala Tyr Leu 
    1100                 1105                 1110             


Met Lys  Ala Gly Ala Asp Pro  Thr Ile Tyr Asn Lys  Ser Glu Arg 
    1115                 1120                 1125             


Ser Ala  Leu His Gln Ala Ala  Ala Asn Arg Asp Phe  Gly Met Met 
    1130                 1135                 1140             


Val Tyr  Met Leu Asn Ser Thr  Lys Leu Lys Gly Asp  Ile Glu Glu 
    1145                 1150                 1155             


Leu Asp  Arg Asn Gly Met Thr  Ala Leu Met Ile Val  Ala His Asn 
    1160                 1165                 1170             


Glu Gly  Arg Asp Gln Val Ala  Ser Ala Lys Leu Leu  Val Glu Lys 
    1175                 1180                 1185             


Gly Ala  Lys Val Asp Tyr Asp  Gly Ala Ala Arg Lys  Asp Ser Glu 
    1190                 1195                 1200             


Lys Tyr  Lys Gly Arg Thr Ala  Leu His Tyr Ala Ala  Gln Val Ser 
    1205                 1210                 1215             


Asn Met  Pro Ile Val Lys Tyr  Leu Val Gly Glu Lys  Gly Ser Asn 
    1220                 1225                 1230             


Lys Asp  Lys Gln Asp Glu Asp  Gly Lys Thr Pro Ile  Met Leu Ala 
    1235                 1240                 1245             


Ala Gln  Glu Gly Arg Ile Glu  Val Val Met Tyr Leu  Ile Gln Gln 
    1250                 1255                 1260             


Gly Ala  Ser Val Glu Ala Val  Asp Ala Thr Asp His  Thr Ala Arg 
    1265                 1270                 1275             


Gln Leu  Ala Gln Ala Asn Asn  His His Asn Ile Val  Asp Ile Phe 
    1280                 1285                 1290             


Asp Arg  Cys Arg Pro Glu Arg  Glu Tyr Ser Met Asp  Leu His Ile 
    1295                 1300                 1305             


Gln His  Thr His Gln Pro Gln  Pro Ser Arg Lys Val  Thr Arg Ala 
    1310                 1315                 1320             


Pro Lys  Lys Gln Thr Ser Arg  Ser Lys Lys Glu Ser  Ala Ser Asn 
    1325                 1330                 1335             


Ser Arg  Asp Ser Thr His Leu  Thr Pro Pro Pro Ser  Asp Gly Ser 
    1340                 1345                 1350             


Thr Ser  Thr Pro Ser Pro Gln  His Phe Met Asn Thr  Thr His Thr 
    1355                 1360                 1365             


Thr Pro  Thr Ser Leu Asn Tyr  Leu Ser Pro Glu Tyr  Gln Thr Glu 
    1370                 1375                 1380             


Ala Gly  Ser Ser Glu Ala Phe  Gln Pro Gln Cys Gly  Ala Phe Gly 
    1385                 1390                 1395             


Asn Gly  Glu Met Trp Tyr Thr  Arg Ala Ser Thr Ser  Tyr Thr Gln 
    1400                 1405                 1410             


Met Gln  Asn Glu Pro Met Thr  Arg Tyr Ser Glu Pro  Ala His Tyr 
    1415                 1420                 1425             


Phe 
    


<210>  4
<211>  2703
<212>  PRT
<213>  Drosophila melanogaster

<400>  4

Met Gln Ser Gln Arg Ser Arg Arg Arg Ser Arg Ala Pro Asn Thr Trp 
1               5                   10                  15      


Ile Cys Phe Trp Ile Asn Lys Met His Ala Val Ala Ser Leu Pro Ala 
            20                  25                  30          


Ser Leu Pro Leu Leu Leu Leu Thr Leu Ala Phe Ala Asn Leu Pro Asn 
        35                  40                  45              


Thr Val Arg Gly Thr Asp Thr Ala Leu Val Ala Ala Ser Cys Thr Ser 
    50                  55                  60                  


Val Gly Cys Gln Asn Gly Gly Thr Cys Val Thr Gln Leu Asn Gly Lys 
65                  70                  75                  80  


Thr Tyr Cys Ala Cys Asp Ser His Tyr Val Gly Asp Tyr Cys Glu His 
                85                  90                  95      


Arg Asn Pro Cys Asn Ser Met Arg Cys Gln Asn Gly Gly Thr Cys Gln 
            100                 105                 110         


Val Thr Phe Arg Asn Gly Arg Pro Gly Ile Ser Cys Lys Cys Pro Leu 
        115                 120                 125             


Gly Phe Asp Glu Ser Leu Cys Glu Ile Ala Val Pro Asn Ala Cys Asp 
    130                 135                 140                 


His Val Thr Cys Leu Asn Gly Gly Thr Cys Gln Leu Lys Thr Leu Glu 
145                 150                 155                 160 


Glu Tyr Thr Cys Ala Cys Ala Asn Gly Tyr Thr Gly Glu Arg Cys Glu 
                165                 170                 175     


Thr Lys Asn Leu Cys Ala Ser Ser Pro Cys Arg Asn Gly Ala Thr Cys 
            180                 185                 190         


Thr Ala Leu Ala Gly Ser Ser Ser Phe Thr Cys Ser Cys Pro Pro Gly 
        195                 200                 205             


Phe Thr Gly Asp Thr Cys Ser Tyr Asp Ile Glu Glu Cys Gln Ser Asn 
    210                 215                 220                 


Pro Cys Lys Tyr Gly Gly Thr Cys Val Asn Thr His Gly Ser Tyr Gln 
225                 230                 235                 240 


Cys Met Cys Pro Thr Gly Tyr Thr Gly Lys Asp Cys Asp Thr Lys Tyr 
                245                 250                 255     


Lys Pro Cys Ser Pro Ser Pro Cys Gln Asn Gly Gly Ile Cys Arg Ser 
            260                 265                 270         


Asn Gly Leu Ser Tyr Glu Cys Lys Cys Pro Lys Gly Phe Glu Gly Lys 
        275                 280                 285             


Asn Cys Glu Gln Asn Tyr Asp Asp Cys Leu Gly His Leu Cys Gln Asn 
    290                 295                 300                 


Gly Gly Thr Cys Ile Asp Gly Ile Ser Asp Tyr Thr Cys Arg Cys Pro 
305                 310                 315                 320 


Pro Asn Phe Thr Gly Arg Phe Cys Gln Asp Asp Val Asp Glu Cys Ala 
                325                 330                 335     


Gln Arg Asp His Pro Val Cys Gln Asn Gly Ala Thr Cys Thr Asn Thr 
            340                 345                 350         


His Gly Ser Tyr Ser Cys Ile Cys Val Asn Gly Trp Ala Gly Leu Asp 
        355                 360                 365             


Cys Ser Asn Asn Thr Asp Asp Cys Lys Gln Ala Ala Cys Phe Tyr Gly 
    370                 375                 380                 


Ala Thr Cys Ile Asp Gly Val Gly Ser Phe Tyr Cys Gln Cys Thr Lys 
385                 390                 395                 400 


Gly Lys Thr Gly Leu Leu Cys His Leu Asp Asp Ala Cys Thr Ser Asn 
                405                 410                 415     


Pro Cys His Ala Asp Ala Ile Cys Asp Thr Ser Pro Ile Asn Gly Ser 
            420                 425                 430         


Tyr Ala Cys Ser Cys Ala Thr Gly Tyr Lys Gly Val Asp Cys Ser Glu 
        435                 440                 445             


Asp Ile Asp Glu Cys Asp Gln Gly Ser Pro Cys Glu His Asn Gly Ile 
    450                 455                 460                 


Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Asn Cys Ser Gln Gly Phe 
465                 470                 475                 480 


Thr Gly Pro Arg Cys Glu Thr Asn Ile Asn Glu Cys Glu Ser His Pro 
                485                 490                 495     


Cys Gln Asn Glu Gly Ser Cys Leu Asp Asp Pro Gly Thr Phe Arg Cys 
            500                 505                 510         


Val Cys Met Pro Gly Phe Thr Gly Thr Gln Cys Glu Ile Asp Ile Asp 
        515                 520                 525             


Glu Cys Gln Ser Asn Pro Cys Leu Asn Asp Gly Thr Cys His Asp Lys 
    530                 535                 540                 


Ile Asn Gly Phe Lys Cys Ser Cys Ala Leu Gly Phe Thr Gly Ala Arg 
545                 550                 555                 560 


Cys Gln Ile Asn Ile Asp Asp Cys Gln Ser Gln Pro Cys Arg Asn Arg 
                565                 570                 575     


Gly Ile Cys His Asp Ser Ile Ala Gly Tyr Ser Cys Glu Cys Pro Pro 
            580                 585                 590         


Gly Tyr Thr Gly Thr Ser Cys Glu Ile Asn Ile Asn Asp Cys Asp Ser 
        595                 600                 605             


Asn Pro Cys His Arg Gly Lys Cys Ile Asp Asp Val Asn Ser Phe Lys 
    610                 615                 620                 


Cys Leu Cys Asp Pro Gly Tyr Thr Gly Tyr Ile Cys Gln Lys Gln Ile 
625                 630                 635                 640 


Asn Glu Cys Glu Ser Asn Pro Cys Gln Phe Asp Gly His Cys Gln Asp 
                645                 650                 655     


Arg Val Gly Ser Tyr Tyr Cys Gln Cys Gln Ala Gly Thr Ser Gly Lys 
            660                 665                 670         


Asn Cys Glu Val Asn Val Asn Glu Cys His Ser Asn Pro Cys Asn Asn 
        675                 680                 685             


Gly Ala Thr Cys Ile Asp Gly Ile Asn Ser Tyr Lys Cys Gln Cys Val 
    690                 695                 700                 


Pro Gly Phe Thr Gly Gln His Cys Glu Lys Asn Val Asp Glu Cys Ile 
705                 710                 715                 720 


Ser Ser Pro Cys Ala Asn Asn Gly Val Cys Ile Asp Gln Val Asn Gly 
                725                 730                 735     


Tyr Lys Cys Glu Cys Pro Arg Gly Phe Tyr Asp Ala His Cys Leu Ser 
            740                 745                 750         


Asp Val Asp Glu Cys Ala Ser Asn Pro Cys Val Asn Glu Gly Arg Cys 
        755                 760                 765             


Glu Asp Gly Ile Asn Glu Phe Ile Cys His Cys Pro Pro Gly Tyr Thr 
    770                 775                 780                 


Gly Lys Arg Cys Glu Leu Asp Ile Asp Glu Cys Ser Ser Asn Pro Cys 
785                 790                 795                 800 


Gln His Gly Gly Thr Cys Tyr Asp Lys Leu Asn Ala Phe Ser Cys Gln 
                805                 810                 815     


Cys Met Pro Gly Tyr Thr Gly Gln Lys Cys Glu Thr Asn Ile Asp Asp 
            820                 825                 830         


Cys Val Thr Asn Pro Cys Gly Asn Gly Gly Thr Cys Ile Asp Lys Val 
        835                 840                 845             


Asn Gly Tyr Lys Cys Val Cys Lys Val Pro Phe Thr Gly Arg Asp Cys 
    850                 855                 860                 


Glu Ser Lys Met Asp Pro Cys Ala Ser Asn Arg Cys Lys Asn Glu Ala 
865                 870                 875                 880 


Lys Cys Thr Pro Ser Ser Asn Phe Leu Asp Phe Ser Cys Thr Cys Lys 
                885                 890                 895     


Leu Gly Tyr Thr Gly Arg Tyr Cys Asp Glu Asp Ile Asp Glu Cys Ser 
            900                 905                 910         


Leu Ser Ser Pro Cys Arg Asn Gly Ala Ser Cys Leu Asn Val Pro Gly 
        915                 920                 925             


Ser Tyr Arg Cys Leu Cys Thr Lys Gly Tyr Glu Gly Arg Asp Cys Ala 
    930                 935                 940                 


Ile Asn Thr Asp Asp Cys Ala Ser Phe Pro Cys Gln Asn Gly Gly Thr 
945                 950                 955                 960 


Cys Leu Asp Gly Ile Gly Asp Tyr Ser Cys Leu Cys Val Asp Gly Phe 
                965                 970                 975     


Asp Gly Lys His Cys Glu Thr Asp Ile Asn Glu Cys Leu Ser Gln Pro 
            980                 985                 990         


Cys Gln Asn Gly Ala Thr Cys Ser  Gln Tyr Val Asn Ser  Tyr Thr Cys 
        995                 1000                 1005             


Thr Cys  Pro Leu Gly Phe Ser  Gly Ile Asn Cys Gln  Thr Asn Asp 
    1010                 1015                 1020             


Glu Asp  Cys Thr Glu Ser Ser  Cys Leu Asn Gly Gly  Ser Cys Ile 
    1025                 1030                 1035             


Asp Gly  Ile Asn Gly Tyr Asn  Cys Ser Cys Leu Ala  Gly Tyr Ser 
    1040                 1045                 1050             


Gly Ala  Asn Cys Gln Tyr Lys  Leu Asn Lys Cys Asp  Ser Asn Pro 
    1055                 1060                 1065             


Cys Leu  Asn Gly Ala Thr Cys  His Glu Gln Asn Asn  Glu Tyr Thr 
    1070                 1075                 1080             


Cys His  Cys Pro Ser Gly Phe  Thr Gly Lys Gln Cys  Ser Glu Tyr 
    1085                 1090                 1095             


Val Asp  Trp Cys Gly Gln Ser  Pro Cys Glu Asn Gly  Ala Thr Cys 
    1100                 1105                 1110             


Ser Gln  Met Lys His Gln Phe  Ser Cys Lys Cys Ser  Ala Gly Trp 
    1115                 1120                 1125             


Thr Gly  Lys Leu Cys Asp Val  Gln Thr Ile Ser Cys  Gln Asp Ala 
    1130                 1135                 1140             


Ala Asp  Arg Lys Gly Leu Ser  Leu Arg Gln Leu Cys  Asn Asn Gly 
    1145                 1150                 1155             


Thr Cys  Lys Asp Tyr Gly Asn  Ser His Val Cys Tyr  Cys Ser Gln 
    1160                 1165                 1170             


Gly Tyr  Ala Gly Ser Tyr Cys  Gln Lys Glu Ile Asp  Glu Cys Gln 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Arg Asp  Leu Ile Gly 
    1190                 1195                 1200             


Ala Tyr  Glu Cys Gln Cys Arg  Gln Gly Phe Gln Gly  Gln Asn Cys 
    1205                 1210                 1215             


Glu Leu  Asn Ile Asp Asp Cys  Ala Pro Asn Pro Cys  Gln Asn Gly 
    1220                 1225                 1230             


Gly Thr  Cys His Asp Arg Val  Met Asn Phe Ser Cys  Ser Cys Pro 
    1235                 1240                 1245             


Pro Gly  Thr Met Gly Ile Ile  Cys Glu Ile Asn Lys  Asp Asp Cys 
    1250                 1255                 1260             


Lys Pro  Gly Ala Cys His Asn  Asn Gly Ser Cys Ile  Asp Arg Val 
    1265                 1270                 1275             


Gly Gly  Phe Glu Cys Val Cys  Gln Pro Gly Phe Val  Gly Ala Arg 
    1280                 1285                 1290             


Cys Glu  Gly Asp Ile Asn Glu  Cys Leu Ser Asn Pro  Cys Ser Asn 
    1295                 1300                 1305             


Ala Gly  Thr Leu Asp Cys Val  Gln Leu Val Asn Asn  Tyr His Cys 
    1310                 1315                 1320             


Asn Cys  Arg Pro Gly His Met  Gly Arg His Cys Glu  His Lys Val 
    1325                 1330                 1335             


Asp Phe  Cys Ala Gln Ser Pro  Cys Gln Asn Gly Gly  Asn Cys Asn 
    1340                 1345                 1350             


Ile Arg  Gln Ser Gly His His  Cys Ile Cys Asn Asn  Gly Phe Tyr 
    1355                 1360                 1365             


Gly Lys  Asn Cys Glu Leu Ser  Gly Gln Asp Cys Asp  Ser Asn Pro 
    1370                 1375                 1380             


Cys Arg  Val Gly Asn Cys Val  Val Ala Asp Glu Gly  Phe Gly Tyr 
    1385                 1390                 1395             


Arg Cys  Glu Cys Pro Arg Gly  Thr Leu Gly Glu His  Cys Glu Ile 
    1400                 1405                 1410             


Asp Thr  Leu Asp Glu Cys Ser  Pro Asn Pro Cys Ala  Gln Gly Ala 
    1415                 1420                 1425             


Ala Cys  Glu Asp Leu Leu Gly  Asp Tyr Glu Cys Leu  Cys Pro Ser 
    1430                 1435                 1440             


Lys Trp  Lys Gly Lys Arg Cys  Asp Ile Tyr Asp Ala  Asn Tyr Pro 
    1445                 1450                 1455             


Gly Trp  Asn Gly Gly Ser Gly  Ser Gly Asn Asp Arg  Tyr Ala Ala 
    1460                 1465                 1470             


Asp Leu  Glu Gln Gln Arg Ala  Met Cys Asp Lys Arg  Gly Cys Thr 
    1475                 1480                 1485             


Glu Lys  Gln Gly Asn Gly Ile  Cys Asp Ser Asp Cys  Asn Thr Tyr 
    1490                 1495                 1500             


Ala Cys  Asn Phe Asp Gly Asn  Asp Cys Ser Leu Gly  Ile Asn Pro 
    1505                 1510                 1515             


Trp Ala  Asn Cys Thr Ala Asn  Glu Cys Trp Asn Lys  Phe Lys Asn 
    1520                 1525                 1530             


Gly Lys  Cys Asn Glu Glu Cys  Asn Asn Ala Ala Cys  His Tyr Asp 
    1535                 1540                 1545             


Gly His  Asp Cys Glu Arg Lys  Leu Lys Ser Cys Asp  Ser Leu Phe 
    1550                 1555                 1560             


Asp Ala  Tyr Cys Gln Lys His  Tyr Gly Asp Gly Phe  Cys Asp Tyr 
    1565                 1570                 1575             


Gly Cys  Asn Asn Ala Glu Cys  Ser Trp Asp Gly Leu  Asp Cys Glu 
    1580                 1585                 1590             


Asn Lys  Thr Gln Ser Pro Val  Leu Ala Glu Gly Ala  Met Ser Val 
    1595                 1600                 1605             


Val Met  Leu Met Asn Val Glu  Ala Phe Arg Glu Ile  Gln Ala Gln 
    1610                 1615                 1620             


Phe Leu  Arg Asn Met Ser His  Met Leu Arg Thr Thr  Val Arg Leu 
    1625                 1630                 1635             


Lys Lys  Asp Ala Leu Gly His  Asp Ile Ile Ile Asn  Trp Lys Asp 
    1640                 1645                 1650             


Asn Val  Arg Val Pro Glu Ile  Glu Asp Thr Asp Phe  Ala Arg Lys 
    1655                 1660                 1665             


Asn Lys  Ile Leu Tyr Thr Gln  Gln Val His Gln Thr  Gly Ile Gln 
    1670                 1675                 1680             


Ile Tyr  Leu Glu Ile Asp Asn  Arg Lys Cys Thr Glu  Cys Phe Thr 
    1685                 1690                 1695             


His Ala  Val Glu Ala Ala Glu  Phe Leu Ala Ala Thr  Ala Ala Lys 
    1700                 1705                 1710             


His Gln  Leu Arg Asn Asp Phe  Gln Ile His Ser Val  Arg Gly Ile 
    1715                 1720                 1725             


Lys Asn  Pro Gly Asp Glu Asp  Asn Gly Glu Pro Pro  Ala Asn Val 
    1730                 1735                 1740             


Lys Tyr  Val Ile Thr Gly Ile  Ile Leu Val Ile Ile  Ala Leu Ala 
    1745                 1750                 1755             


Phe Phe  Gly Met Val Leu Ser  Thr Gln Arg Lys Arg  Ala His Gly 
    1760                 1765                 1770             


Val Thr  Trp Phe Pro Glu Gly  Phe Arg Ala Pro Ala  Ala Val Met 
    1775                 1780                 1785             


Ser Arg  Arg Arg Arg Asp Pro  His Gly Gln Glu Met  Arg Asn Leu 
    1790                 1795                 1800             


Asn Lys  Gln Val Ala Met Gln  Ser Gln Gly Val Gly  Gln Pro Gly 
    1805                 1810                 1815             


Ala His  Trp Ser Asp Asp Glu  Ser Asp Met Pro Leu  Pro Lys Arg 
    1820                 1825                 1830             


Gln Arg  Ser Asp Pro Val Ser  Gly Val Gly Leu Gly  Asn Asn Gly 
    1835                 1840                 1845             


Gly Tyr  Ala Ser Asp His Thr  Met Val Ser Glu Tyr  Glu Glu Ala 
    1850                 1855                 1860             


Asp Gln  Arg Val Trp Ser Gln  Ala His Leu Asp Val  Val Asp Val 
    1865                 1870                 1875             


Arg Ala  Ile Met Thr Pro Pro  Ala His Gln Asp Gly  Gly Lys His 
    1880                 1885                 1890             


Asp Val  Asp Ala Arg Gly Pro  Cys Gly Leu Thr Pro  Leu Met Ile 
    1895                 1900                 1905             


Ala Ala  Val Arg Gly Gly Gly  Leu Asp Thr Gly Glu  Asp Ile Glu 
    1910                 1915                 1920             


Asn Asn  Glu Asp Ser Thr Ala  Gln Val Ile Ser Asp  Leu Leu Ala 
    1925                 1930                 1935             


Gln Gly  Ala Glu Leu Asn Ala  Thr Met Asp Lys Thr  Gly Glu Thr 
    1940                 1945                 1950             


Ser Leu  His Leu Ala Ala Arg  Phe Ala Arg Ala Asp  Ala Ala Lys 
    1955                 1960                 1965             


Arg Leu  Leu Asp Ala Gly Ala  Asp Ala Asn Cys Gln  Asp Asn Thr 
    1970                 1975                 1980             


Gly Arg  Thr Pro Leu His Ala  Ala Val Ala Ala Asp  Ala Met Gly 
    1985                 1990                 1995             


Val Phe  Gln Ile Leu Leu Arg  Asn Arg Ala Thr Asn  Leu Asn Ala 
    2000                 2005                 2010             


Arg Met  His Asp Gly Thr Thr  Pro Leu Ile Leu Ala  Ala Arg Leu 
    2015                 2020                 2025             


Ala Ile  Glu Gly Met Val Glu  Asp Leu Ile Thr Ala  Asp Ala Asp 
    2030                 2035                 2040             


Ile Asn  Ala Ala Asp Asn Ser  Gly Lys Thr Ala Leu  His Trp Ala 
    2045                 2050                 2055             


Ala Ala  Val Asn Asn Thr Glu  Ala Val Asn Ile Leu  Leu Met His 
    2060                 2065                 2070             


His Ala  Asn Arg Asp Ala Gln  Asp Asp Lys Asp Glu  Thr Pro Leu 
    2075                 2080                 2085             


Phe Leu  Ala Ala Arg Glu Gly  Ser Tyr Glu Ala Cys  Lys Ala Leu 
    2090                 2095                 2100             


Leu Asp  Asn Phe Ala Asn Arg  Glu Ile Thr Asp His  Met Asp Arg 
    2105                 2110                 2115             


Leu Pro  Arg Asp Val Ala Ser  Glu Arg Leu His His  Asp Ile Val 
    2120                 2125                 2130             


Arg Leu  Leu Asp Glu His Val  Pro Arg Ser Pro Gln  Met Leu Ser 
    2135                 2140                 2145             


Met Thr  Pro Gln Ala Met Ile  Gly Ser Pro Pro Pro  Gly Gln Gln 
    2150                 2155                 2160             


Gln Pro  Gln Leu Ile Thr Gln  Pro Thr Val Ile Ser  Ala Gly Asn 
    2165                 2170                 2175             


Gly Gly  Asn Asn Gly Asn Gly  Asn Ala Ser Gly Lys  Gln Ser Asn 
    2180                 2185                 2190             


Gln Thr  Ala Lys Gln Lys Ala  Ala Lys Lys Ala Lys  Leu Ile Glu 
    2195                 2200                 2205             


Gly Ser  Pro Asp Asn Gly Leu  Asp Ala Thr Gly Ser  Leu Arg Arg 
    2210                 2215                 2220             


Lys Ala  Ser Ser Lys Lys Thr  Ser Ala Ala Ser Lys  Lys Ala Ala 
    2225                 2230                 2235             


Asn Leu  Asn Gly Leu Asn Pro  Gly Gln Leu Thr Gly  Gly Val Ser 
    2240                 2245                 2250             


Gly Val  Pro Gly Val Pro Pro  Thr Asn Ser Ala Ala  Gln Ala Ala 
    2255                 2260                 2265             


Ala Ala  Ala Ala Ala Ala Val  Ala Ala Met Ser His  Glu Leu Glu 
    2270                 2275                 2280             


Gly Ser  Pro Val Gly Val Gly  Met Gly Gly Asn Leu  Pro Ser Pro 
    2285                 2290                 2295             


Tyr Asp  Thr Ser Ser Met Tyr  Ser Asn Ala Met Ala  Ala Pro Leu 
    2300                 2305                 2310             


Ala Asn  Gly Asn Pro Asn Thr  Gly Ala Lys Gln Pro  Pro Ser Tyr 
    2315                 2320                 2325             


Glu Asp  Cys Ile Lys Asn Ala  Gln Ser Met Gln Ser  Leu Gln Gly 
    2330                 2335                 2340             


Asn Gly  Leu Asp Met Ile Lys  Leu Asp Asn Tyr Ala  Tyr Ser Met 
    2345                 2350                 2355             


Gly Ser  Pro Phe Gln Gln Glu  Leu Leu Asn Gly Gln  Gly Leu Gly 
    2360                 2365                 2370             


Met Asn  Gly Asn Gly Gln Arg  Asn Gly Val Gly Pro  Gly Val Leu 
    2375                 2380                 2385             


Pro Gly  Gly Leu Cys Gly Met  Gly Gly Leu Ser Gly  Ala Gly Asn 
    2390                 2395                 2400             


Gly Asn  Ser His Glu Gln Gly  Leu Ser Pro Pro Tyr  Ser Asn Gln 
    2405                 2410                 2415             


Ser Pro  Pro His Ser Val Gln  Ser Ser Leu Ala Leu  Ser Pro His 
    2420                 2425                 2430             


Ala Tyr  Leu Gly Ser Pro Ser  Pro Ala Lys Ser Arg  Pro Ser Leu 
    2435                 2440                 2445             


Pro Thr  Ser Pro Thr His Ile  Gln Ala Met Arg His  Ala Thr Gln 
    2450                 2455                 2460             


Gln Lys  Gln Phe Gly Gly Ser  Asn Leu Asn Ser Leu  Leu Gly Gly 
    2465                 2470                 2475             


Ala Asn  Gly Gly Gly Val Val  Gly Gly Gly Gly Gly  Gly Gly Gly 
    2480                 2485                 2490             


Gly Val  Gly Gln Gly Pro Gln  Asn Ser Pro Val Ser  Leu Gly Ile 
    2495                 2500                 2505             


Ile Ser  Pro Thr Gly Ser Asp  Met Gly Ile Met Leu  Ala Pro Pro 
    2510                 2515                 2520             


Gln Ser  Ser Lys Asn Ser Ala  Ile Met Gln Thr Ile  Ser Pro Gln 
    2525                 2530                 2535             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Gln Gln 
    2540                 2545                 2550             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2555                 2560                 2565             


Leu Gly  Gly Leu Glu Phe Gly  Ser Ala Gly Leu Asp  Leu Asn Gly 
    2570                 2575                 2580             


Phe Cys  Gly Ser Pro Asp Ser  Phe His Ser Gly Gln  Met Asn Pro 
    2585                 2590                 2595             


Pro Ser  Ile Gln Ser Ser Met  Ser Gly Ser Ser Pro  Ser Thr Asn 
    2600                 2605                 2610             


Met Leu  Ser Pro Ser Ser Gln  His Asn Gln Gln Ala  Phe Tyr Gln 
    2615                 2620                 2625             


Tyr Leu  Thr Pro Ser Ser Gln  His Ser Gly Gly His  Thr Pro Gln 
    2630                 2635                 2640             


His Leu  Val Gln Thr Leu Asp  Ser Tyr Pro Thr Pro  Ser Pro Glu 
    2645                 2650                 2655             


Ser Pro  Gly His Trp Ser Ser  Ser Ser Pro Arg Ser  Asn Ser Asp 
    2660                 2665                 2670             


Trp Ser  Glu Gly Val Gln Ser  Pro Ala Ala Asn Asn  Leu Tyr Ile 
    2675                 2680                 2685             


Ser Gly  Gly His Gln Ala Asn  Lys Gly Ser Glu Ala  Ile Tyr Ile 
    2690                 2695                 2700             


<210>  5
<211>  2900
<212>  PRT
<213>  Bos taurus

<400>  5

Met Thr Pro Val Cys Thr Pro Thr Arg Pro Gly Pro Cys Ala His Pro 
1               5                   10                  15      


Ala Leu Pro Arg Ser Thr Pro His Ser Ile Thr Asp Ser Ser Arg Ala 
            20                  25                  30          


Glu Pro Ile Glu Ser Phe Leu Val Leu Ser Pro Ala Leu Glu Leu Arg 
        35                  40                  45              


Leu Leu Leu Ala Val Val Gly Gln Asp Thr Pro Leu Gly Asp Val Trp 
    50                  55                  60                  


Ala Gly Gly Lys Ala Ser Gly Gly Gly Asp Thr Glu Gly Pro Leu Ser 
65                  70                  75                  80  


Glu Gly Ser Lys Glu Gly Glu Ala Ala Thr Gly Pro Gln Ala Pro Gly 
                85                  90                  95      


Ala Glu Trp His Ala Pro Pro Arg Ser Thr Cys Leu Ser Ser Thr Pro 
            100                 105                 110         


Arg Pro Glu Ala Val Pro Pro Ser Leu Pro Cys Arg Ser Pro Gly Trp 
        115                 120                 125             


Gly Ala Cys Gly Gly Arg Arg Pro Gly Pro Ala Leu Glu Pro Ala His 
    130                 135                 140                 


Met Gly Ser Val Pro Ser Gln Gln Arg Pro Pro Gly Leu Asp Arg Ser 
145                 150                 155                 160 


Arg Glu Asp Asn Gly Pro Pro Gln Pro Leu Pro Ser Pro His Gly Gly 
                165                 170                 175     


Ala Ser Leu Ala Pro Ala Pro Pro Pro Ala Cys Arg Gly Trp Gln Pro 
            180                 185                 190         


Pro Leu Arg Trp Pro Gly Ala Ala Ala Ala Arg Val Pro Gly His Arg 
        195                 200                 205             


Arg Thr Cys Ser Pro Ala Ala Leu Cys Pro Cys Cys Arg Cys Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Arg Phe Ser Ser His Cys Asn Ser Arg Ser Leu Pro Gly 
225                 230                 235                 240 


Gln Asp Ala Leu Gly Pro Gly Leu Trp Val Pro Ser Ala Thr Gln Ala 
                245                 250                 255     


Gly Thr Arg Gln Pro Val Thr Gly Ser Thr Leu Ser Gly Gly His Ala 
            260                 265                 270         


Thr Phe Pro Arg Leu Gln Gly Met Ala Leu Pro Glu Pro Glu Gly Glu 
        275                 280                 285             


Gly Pro Pro Thr Thr Ser Ala Gln Gly Cys Gly Pro Ser Val Arg Ala 
    290                 295                 300                 


Ala Phe Pro Gly Arg Cys Gln Leu Gly Ala Val Gly Ala Phe His Pro 
305                 310                 315                 320 


Arg Gly Ser Ala Ala Gly Lys Arg Glu Ala Trp Leu Val Pro Glu Pro 
                325                 330                 335     


Leu Leu Gly Phe Pro Ser Ser Ser Arg Leu Arg Gly Asp Pro Gly Gly 
            340                 345                 350         


His Val Pro Pro Arg Leu Lys Lys Pro Arg Gln Gln Val Ala Lys Gly 
        355                 360                 365             


Gly Pro Gly Ala Gly Val Ala Gly Ala Glu Pro Phe Pro Val Gly Ser 
    370                 375                 380                 


Ala Gly Asp Gln Ala Trp Gly Trp Ala Gly Gly Lys Ala Pro Pro Thr 
385                 390                 395                 400 


Pro Gly Ser Pro Ala Thr Val Ala Ala Arg Glu Pro Ala Gln Gly Leu 
                405                 410                 415     


Pro Asp Cys Gly Gly Ala Phe Ala Gly Gln Gln Cys Gln Ala Pro Asn 
            420                 425                 430         


Pro Cys Leu Ser Ala Pro Cys Lys Asn Gly Gly Thr Cys His Thr Thr 
        435                 440                 445             


Glu Arg Glu Gly Leu Val Asp Tyr Val Cys Gly Cys Arg Leu Gly Phe 
    450                 455                 460                 


Ser Gly Pro Leu Cys Leu Thr Pro Arg Asp His Ala Cys Leu Ala Ser 
465                 470                 475                 480 


Pro Cys Leu Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr 
                485                 490                 495     


Lys Cys Leu Cys Thr Pro Gly Trp Ser Gly Lys Thr Cys Gln Gln Ala 
            500                 505                 510         


Asp Pro Cys Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro 
        515                 520                 525             


Phe Glu Ala Ser Tyr Ile Cys His Cys Pro Pro Gly Phe His Gly Pro 
    530                 535                 540                 


Thr Cys Arg Gln Asp Val Asn Glu Cys Ser Gln Ser Pro Gly Leu Cys 
545                 550                 555                 560 


His His Gly Gly Thr Cys Leu Asn Glu Val Gly Ser Tyr Arg Cys Val 
                565                 570                 575     


Cys Arg Pro Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro 
            580                 585                 590         


Cys Ser Pro Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly 
        595                 600                 605             


Asp Thr Thr His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn 
    610                 615                 620                 


Cys Glu Glu Asn Ile Asp Asp Cys Pro Gly Asn Ser Cys Lys Asn Gly 
625                 630                 635                 640 


Gly Ala Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
                645                 650                 655     


Glu Trp Thr Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu 
            660                 665                 670         


Met Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly 
        675                 680                 685             


Gly Tyr Asn Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser 
    690                 695                 700                 


Glu Asn Ile Asp Asp Cys Ala Ser Ala Ser Cys Phe Gln Gly Ala Thr 
705                 710                 715                 720 


Cys His Asp Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg 
                725                 730                 735     


Thr Gly Leu Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys 
            740                 745                 750         


Asn Glu Gly Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile 
        755                 760                 765             


Cys Thr Cys Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val 
    770                 775                 780                 


Asp Glu Cys Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys 
785                 790                 795                 800 


Ile Asn Thr Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr 
                805                 810                 815     


Gly Pro Arg Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys 
            820                 825                 830         


Gln Asn Asp Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile 
        835                 840                 845             


Cys Met Pro Gly Tyr Glu Gly Leu His Cys Glu Val Asn Thr Asp Glu 
    850                 855                 860                 


Cys Ala Ser Ser Pro Cys Leu Gln Asn Gly Arg Cys Leu Asp Lys Ile 
865                 870                 875                 880 


Asn Glu Phe Val Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys 
                885                 890                 895     


Gln Tyr Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala 
            900                 905                 910         


Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly 
        915                 920                 925             


Tyr Thr Gly Pro His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp 
    930                 935                 940                 


Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys 
945                 950                 955                 960 


Leu Cys Gln Pro Gly Tyr Thr Gly His His Cys Glu Ser Asn Ile Asn 
                965                 970                 975     


Glu Cys His Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg 
            980                 985                 990         


Asp Asn Ala Tyr Leu Cys Phe Cys  Leu Lys Gly Thr Thr  Gly Pro Asn 
        995                 1000                 1005             


Cys Glu  Ile Asn Leu Asp Asp  Cys Ala Ser Asn Pro  Cys Asp Ser 
    1010                 1015                 1020             


Gly Thr  Cys Leu Asp Lys Ile  Asp Gly Tyr Glu Cys  Ala Cys Glu 
    1025                 1030                 1035             


Pro Gly  Tyr Thr Gly Ser Met  Cys Asn Ile Asn Ile  Asp Glu Cys 
    1040                 1045                 1050             


Ala Asp  Ser Pro Cys His Asn  Gly Gly Thr Cys Glu  Asp Gly Ile 
    1055                 1060                 1065             


Asn Gly  Phe Thr Cys Arg Cys  Pro Glu Gly Tyr His  Asp Pro Thr 
    1070                 1075                 1080             


Cys Leu  Ser Glu Val Asn Glu  Cys Ser Ser Asn Pro  Cys Ile His 
    1085                 1090                 1095             


Gly Ala  Cys Arg Asp Ser Leu  Asn Gly Tyr Lys Cys  Asp Cys Asp 
    1100                 1105                 1110             


Pro Gly  Trp Ser Gly Ala Asn  Cys Asp Val Asn Asn  Asp Glu Cys 
    1115                 1120                 1125             


Glu Ser  Asn Pro Cys Ile Asn  Gly Gly Thr Cys Lys  Asp Met Thr 
    1130                 1135                 1140             


Ser Gly  Tyr Val Cys Ala Cys  Arg Glu Gly Phe Ser  Gly Pro Asn 
    1145                 1150                 1155             


Cys Gln  Thr Asn Ile Asn Glu  Cys Ala Ser Asn Pro  Cys Leu Asn 
    1160                 1165                 1170             


Gln Gly  Thr Cys Ile Asp Asp  Val Ala Gly Tyr Lys  Cys Asn Cys 
    1175                 1180                 1185             


Leu Leu  Pro Tyr Thr Gly Ala  Thr Cys Glu Val Val  Leu Ala Pro 
    1190                 1195                 1200             


Cys Ala  Pro Gly Pro Cys Arg  Asn Gly Gly Glu Cys  Arg Glu Ser 
    1205                 1210                 1215             


Glu Asp  Tyr Glu Ser Phe Ser  Cys Ala Cys Pro Ala  Gly Trp Gln 
    1220                 1225                 1230             


Gly Gln  Thr Cys Glu Ile Asp  Ile Asn Glu Cys Val  Lys Ser Pro 
    1235                 1240                 1245             


Cys Arg  Ala Gly Ala Ser Cys  Gln Asn Thr Asn Gly  Ser Tyr Arg 
    1250                 1255                 1260             


Cys His  Cys Gln Ala Gly Tyr  Thr Gly Arg Asn Cys  Glu Thr Asp 
    1265                 1270                 1275             


Ile Asp  Asp Cys Arg Pro Asn  Pro Cys His Asn Gly  Gly Ser Cys 
    1280                 1285                 1290             


Thr Asp  Gly Ile Asn Thr Ala  Phe Cys Asp Cys Leu  Pro Gly Phe 
    1295                 1300                 1305             


Gln Gly  Ala Phe Cys Glu Glu  Asp Ile Asn Glu Cys  Ala Ser Ser 
    1310                 1315                 1320             


Pro Cys  Arg Asn Gly Ala Asn  Cys Thr Asp Cys Val  Asp Ser Tyr 
    1325                 1330                 1335             


Thr Cys  Thr Cys Pro Thr Gly  Phe Ser Gly Ile His  Cys Glu Asn 
    1340                 1345                 1350             


Asn Thr  Pro Asp Cys Thr Glu  Ser Ser Cys Phe Asn  Gly Gly Thr 
    1355                 1360                 1365             


Cys Val  Asp Gly Ile Asn Ser  Phe Thr Cys Leu Cys  Pro Pro Gly 
    1370                 1375                 1380             


Phe Thr  Gly Ser Tyr Cys Gln  His Asp Val Asn Glu  Cys Asp Ser 
    1385                 1390                 1395             


Arg Pro  Cys Leu His Gly Gly  Thr Cys His Asp Ser  Tyr Gly Thr 
    1400                 1405                 1410             


Tyr Thr  Cys Thr Cys Pro Gln  Gly Tyr Thr Gly Leu  Asn Cys Gln 
    1415                 1420                 1425             


Thr Leu  Val Arg Trp Cys Asp  Ser Ser Pro Cys Lys  Asn Asp Gly 
    1430                 1435                 1440             


Arg Cys  Trp Gln Thr Asn Ala  Leu Tyr Arg Cys Glu  Cys His Ser 
    1445                 1450                 1455             


Gly Trp  Thr Gly Leu Tyr Cys  Asp Val Pro Ser Val  Ser Cys Glu 
    1460                 1465                 1470             


Val Ala  Ala Arg Gln Gln Gly  Val Asn Val Thr His  Leu Cys Arg 
    1475                 1480                 1485             


Asn Gly  Gly Leu Cys Met Asn  Ala Gly Asn Thr His  Arg Cys His 
    1490                 1495                 1500             


Cys Gln  Ala Gly Tyr Thr Gly  Ser Tyr Cys Glu Glu  Gln Val Asp 
    1505                 1510                 1515             


Glu Cys  Ser Pro Ser Pro Cys  Gln Asn Gly Ala Thr  Cys Thr Asp 
    1520                 1525                 1530             


Tyr Pro  Gly Gly Tyr Ser Cys  Glu Cys Val Ala Gly  Tyr His Gly 
    1535                 1540                 1545             


Val Asn  Cys Ser Glu Glu Val  Asn Glu Cys Leu Ser  Gln Pro Cys 
    1550                 1555                 1560             


Arg Asn  Gly Gly Thr Cys Ile  Asp Leu Thr Asn Thr  Tyr Lys Cys 
    1565                 1570                 1575             


Ser Cys  Pro Arg Gly Thr Gln  Gly Val His Cys Glu  Ile Asn Val 
    1580                 1585                 1590             


Asp Asp  Cys Asn Pro Pro Ile  Asp Pro Val Ser Arg  Gly Pro Lys 
    1595                 1600                 1605             


Cys Phe  Asn Asn Gly Thr Cys  Val Asp Gln Val Gly  Gly Tyr Ser 
    1610                 1615                 1620             


Cys Ser  Cys Pro Pro Gly Phe  Val Gly Glu Arg Cys  Glu Gly Asp 
    1625                 1630                 1635             


Val Asn  Glu Cys Leu Ser Asn  Pro Cys Asp Ala Arg  Gly Thr Gln 
    1640                 1645                 1650             


Asn Cys  Val Gln His Val Asn  Ala Phe His Cys Glu  Cys Arg Ala 
    1655                 1660                 1665             


Gly His  Thr Gly Arg Arg Cys  Glu Ser Val Ile Asn  Gly Cys Lys 
    1670                 1675                 1680             


Asp Arg  Pro Cys Lys Asn Gly  Gly Ser Cys Ala Val  Ala Ser Asn 
    1685                 1690                 1695             


Thr Ala  Arg Gly Phe Ile Cys  Lys Cys Pro Ala Gly  Phe Glu Gly 
    1700                 1705                 1710             


Ala Thr  Cys Glu Asn Asp Ala  Arg Ser Cys Gly Ser  Leu Arg Cys 
    1715                 1720                 1725             


Leu Asn  Gly Gly Thr Cys Ile  Ala Gly Pro Arg Ser  Pro Thr Cys 
    1730                 1735                 1740             


Leu Cys  Leu Gly Pro Phe Thr  Gly Pro Glu Cys Gln  Phe Pro Ala 
    1745                 1750                 1755             


Ser Ser  Pro Cys Val Gly Gly  Asn Pro Cys Tyr Asn  Gln Gly Val 
    1760                 1765                 1770             


Cys Glu  Pro Thr Ala Glu Ser  Pro Phe Tyr Arg Cys  Arg Cys Pro 
    1775                 1780                 1785             


Ala Lys  Phe Asn Gly Leu Leu  Cys His Ile Leu Asp  Tyr Ser Phe 
    1790                 1795                 1800             


Gly Gly  Gly Val Gly Leu Asp  Ile Pro Pro Pro Gln  Ile Glu Glu 
    1805                 1810                 1815             


Thr Cys  Glu Leu Pro Gly Cys  Arg Glu Glu Ala Gly  Asn Lys Val 
    1820                 1825                 1830             


Cys Ser  Leu Gln Cys Asn Ser  His Ala Cys Gly Trp  Asp Gly Gly 
    1835                 1840                 1845             


Asp Cys  Ser Leu Asp Phe Asp  Asp Pro Trp Gln Asn  Cys Thr Gln 
    1850                 1855                 1860             


Ser Leu  Gln Cys Trp Lys Tyr  Phe Ser Asn Gly Arg  Cys Asp Ser 
    1865                 1870                 1875             


Gln Cys  Asn Ser Ala Gly Cys  Leu Phe Asp Gly Phe  Asp Cys Gln 
    1880                 1885                 1890             


Arg Ala  Glu Gly Gln Cys Asn  Pro Leu Tyr Asp Gln  Tyr Cys Lys 
    1895                 1900                 1905             


Asp His  Phe Arg Asp Gly His  Cys Asp Gln Gly Cys  Asn Ser Ala 
    1910                 1915                 1920             


Glu Cys  Glu Trp Asp Gly Leu  Asp Cys Ala Glu His  Val Pro Glu 
    1925                 1930                 1935             


Arg Leu  Ala Ala Gly Thr Leu  Val Leu Val Val Leu  Met Pro Pro 
    1940                 1945                 1950             


Glu Gln  Leu Arg Asn Arg Ser  Leu His Phe Leu Arg  Glu Leu Ser 
    1955                 1960                 1965             


Arg Leu  Leu His Thr Asn Val  Val Phe Lys Arg Asp  Ala Ser Gly 
    1970                 1975                 1980             


Gln Gln  Met Ile Phe Pro Tyr  Tyr Gly Arg Ala Pro  Leu Pro Ala 
    1985                 1990                 1995             


Gly Glu  Arg Ser Glu Glu Cys  Arg Cys Glu His His  Ala Cys Pro 
    2000                 2005                 2010             


Ala Gly  Ala Gly Gln Gly Glu  Pro Ser Gly Pro Leu  Cys Thr Ser 
    2015                 2020                 2025             


Arg Ser  Ile Val Tyr Leu Glu  Ile Asp Asn Arg Gln  Cys Val Gln 
    2030                 2035                 2040             


Ser Ser  Ser Gln Cys Phe Gln  Ser Ala Thr Asp Val  Ala Ala Phe 
    2045                 2050                 2055             


Leu Gly  Ala Leu Ala Ser Leu  Gly Ser Leu Asn Ile  Pro Tyr Lys 
    2060                 2065                 2070             


Ile Glu  Ala Val Gln Ser Glu  Thr Val Glu Pro Pro  Pro Pro Pro 
    2075                 2080                 2085             


Pro Leu  His Phe Met Tyr Val  Ala Val Val Ala Phe  Val Leu Leu 
    2090                 2095                 2100             


Phe Phe  Val Gly Cys Gly Val  Leu Leu Ser Arg Lys  Arg Arg Arg 
    2105                 2110                 2115             


Gln His  Gly Gln Leu Trp Phe  Pro Glu Gly Phe Lys  Val Ser Glu 
    2120                 2125                 2130             


Ala Ser  Lys Lys Lys Arg Arg  Glu Pro Leu Gly Glu  Asp Ser Val 
    2135                 2140                 2145             


Gly Leu  Lys Pro Leu Lys Asn  Ser Ser Asp Gly Ala  Leu Met Asp 
    2150                 2155                 2160             


Asp Asn  Gln Asn Glu Trp Gly  Asp Glu Gly Leu Glu  Ala Lys Lys 
    2165                 2170                 2175             


Phe Arg  Phe Glu Glu Pro Val  Val Leu Pro Asp Leu  Asp Asp Gln 
    2180                 2185                 2190             


Thr Asp  His Arg Gln Trp Thr  Gln Gln His Leu Asp  Ala Ala Asp 
    2195                 2200                 2205             


Leu Arg  Val Ser Ala Met Ala  Pro Thr Pro Pro Gln  Gly Glu Ala 
    2210                 2215                 2220             


Asp Ala  Asp Cys Met Asp Val  Asn Val Arg Gly Pro  Asp Gly Phe 
    2225                 2230                 2235             


Thr Pro  Leu Met Ile Ala Ser  Cys Ser Gly Gly Gly  Leu Glu Thr 
    2240                 2245                 2250             


Gly Asn  Ser Glu Glu Glu Glu  Asp Ala Pro Ala Val  Ile Ser Asp 
    2255                 2260                 2265             


Phe Ile  Tyr Gln Gly Ala Ser  Leu His Asn Gln Thr  Asp Arg Thr 
    2270                 2275                 2280             


Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg Tyr Ser  Arg Ser Asp 
    2285                 2290                 2295             


Ala Ala  Lys Arg Leu Leu Glu  Ala Ser Ala Asp Ala  Asn Ile Gln 
    2300                 2305                 2310             


Asp Asn  Met Gly Arg Thr Pro  Leu His Ala Ala Val  Ser Ala Asp 
    2315                 2320                 2325             


Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg Asn Arg  Ala Thr Asp 
    2330                 2335                 2340             


Leu Asp  Ala Arg Met His Asp  Gly Thr Thr Pro Leu  Ile Leu Ala 
    2345                 2350                 2355             


Ala Arg  Leu Ala Val Glu Gly  Met Leu Glu Asp Leu  Ile Asn Ser 
    2360                 2365                 2370             


His Ala  Asp Val Asn Ala Val  Asp Asp Leu Gly Lys  Ser Ala Leu 
    2375                 2380                 2385             


His Trp  Ala Ala Ala Val Asn  Asn Val Glu Ala Ala  Val Val Leu 
    2390                 2395                 2400             


Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln Asn Asn  Lys Glu Glu 
    2405                 2410                 2415             


Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly Ser Tyr  Glu Thr Ala 
    2420                 2425                 2430             


Lys Val  Leu Leu Asp His Phe  Ala Asn Arg Asp Ile  Thr Asp His 
    2435                 2440                 2445             


Met Asp  Arg Leu Pro Arg Asp  Ile Ala Gln Glu Arg  Met His His 
    2450                 2455                 2460             


Asp Ile  Val Arg Leu Leu Asp  Glu Tyr Ser Leu Val  Arg Ser Pro 
    2465                 2470                 2475             


Pro Leu  His Gly Ala Thr Leu  Gly Gly Thr Pro Thr  Leu Ser Pro 
    2480                 2485                 2490             


Pro Leu  Cys Ser Pro Asn Gly  Tyr Leu Gly Asn Leu  Lys Pro Pro 
    2495                 2500                 2505             


Met Gln  Gly Lys Lys Ala Arg  Lys Pro Ser Thr Lys  Gly Leu Ala 
    2510                 2515                 2520             


Cys Gly  Gly Lys Glu Pro Lys  Asp Leu Lys Ala Arg  Arg Lys Lys 
    2525                 2530                 2535             


Ser Gln  Asp Gly Lys Gly Cys  Leu Leu Asp Ser Gly  Ser Val Met 
    2540                 2545                 2550             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Gly Tyr  Leu Ser Asp 
    2555                 2560                 2565             


Val Ala  Ser Pro Pro Leu Leu  Pro Ser Pro Phe Gln  Pro Ser Pro 
    2570                 2575                 2580             


Ser Val  Pro Leu Asn His Leu  Pro Gly Met Pro Glu  Thr His Leu 
    2585                 2590                 2595             


Gly Val  Ser His Leu Ser Val  Ala Ala Lys Pro Glu  Met Ala Val 
    2600                 2605                 2610             


Leu Ser  Gly Gly Ser Arg Leu  Ala Phe Glu Ala Gly  Pro Pro Arg 
    2615                 2620                 2625             


Leu Ser  His Leu Pro Val Ala  Ser Ser Thr Ser Thr  Ile Leu Gly 
    2630                 2635                 2640             


Ser Gly  Gly Ser Gly Gly Ser  Gly Ala Val Asn Phe  Thr Val Gly 
    2645                 2650                 2655             


Gly Ala  Ala Gly Leu Asn Gly  Gln Cys Glu Trp Leu  Ser Arg Leu 
    2660                 2665                 2670             


Gln Asn  Gly Leu Val Pro Asn  Gln Tyr Asn Pro Leu  Arg Gly Gly 
    2675                 2680                 2685             


Val Thr  Pro Gly Thr Leu Ser  Thr Gln Ala Ala Gly  Leu Gln His 
    2690                 2695                 2700             


Gly Thr  Val Gly Pro Leu His  Ala Pro Ala Leu Ser  Gln Val Met 
    2705                 2710                 2715             


Thr Tyr  Gln Ala Leu Pro Ser  Thr Arg Leu Ala Ser  Gln Pro His 
    2720                 2725                 2730             


Leu Val  Gln Pro Gln Gln Asn  Leu Gln Met Gln Pro  Pro Ser Met 
    2735                 2740                 2745             


Pro Pro  Gln Pro Asn Leu Gln  Pro His Leu Gly Val  Ser Ser Ala 
    2750                 2755                 2760             


Ala Ser  Gly His Leu Gly Arg  Ser Phe Leu Gly Gly  Glu Leu Ser 
    2765                 2770                 2775             


Gln Ala  Asp Met Gln Pro Leu  Gly Pro Gly Asn Leu  Ala Ala His 
    2780                 2785                 2790             


Thr Val  Leu Pro Gln Asp Gly  Gln Val Leu Pro Thr  Ser Leu Pro 
    2795                 2800                 2805             


Ser Thr  Leu Ala Pro Pro Thr  Met Ala Pro Pro Met  Thr Thr Ala 
    2810                 2815                 2820             


Gln Phe  Leu Thr Pro Pro Ser  Gln His Ser Tyr Ser  Ser Ser Pro 
    2825                 2830                 2835             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2840                 2845                 2850             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2855                 2860                 2865             


Ser Pro  His Ser Asn Ile Ser  Asp Trp Ser Glu Gly  Ile Ser Ser 
    2870                 2875                 2880             


Pro Pro  Thr Ser Val Pro Ser  Gln Ile Ala His Val  Pro Glu Ala 
    2885                 2890                 2895             


Phe Lys  
    2900 


<210>  6
<211>  2561
<212>  PRT
<213>  Gallus gallus

<400>  6

Met Gly Arg Cys Ser Ala Ala His Pro Arg Gly Gly Val His Cys Pro 
1               5                   10                  15      


Gly Leu Cys Ala Val Pro Asp Ala Leu Leu Leu Phe Pro Gly Val Arg 
            20                  25                  30          


Cys Thr Gln Leu Ala Glu Ser Cys Leu Asn Gly Gly Lys Cys Glu Thr 
        35                  40                  45              


Phe Leu Asn Gly Thr Glu Val Cys Gln Cys Ser Ser Ala His Met Gly 
    50                  55                  60                  


Glu Arg Cys Gln Leu Pro Asn Pro Cys Leu Ser Ser Pro Cys Lys Asn 
65                  70                  75                  80  


Ala Gly Thr Cys Ile Pro Leu Leu Arg Gly Ser Thr Ala Asp Tyr Thr 
                85                  90                  95      


Cys Val Cys Arg Leu Gly Phe Thr Asp Glu Leu Cys Leu Thr Pro Leu 
            100                 105                 110         


Asp Asn Ala Cys Leu Asn Asn Pro Cys Arg Asn Gly Gly Thr Cys Asp 
        115                 120                 125             


Leu Val Thr Leu Ser Glu Tyr Lys Cys Arg Cys Pro Pro Gly Trp Ser 
    130                 135                 140                 


Gly Lys Thr Cys Gln Gln Ala Asp Pro Cys Ala Ser Asn Pro Cys Ala 
145                 150                 155                 160 


Asn Gly Gly Gln Cys Val Pro Phe Glu Ala His Tyr Ile Cys Arg Cys 
                165                 170                 175     


Thr Ala Gly Phe His Gly Ala Asn Cys Lys Gln Asp Val Asn Glu Cys 
            180                 185                 190         


Asn Ile Ser Pro Pro Val Cys Lys Asn Gly Gly Ser Cys Thr Asn Glu 
        195                 200                 205             


Val Gly Thr Tyr Gln Cys Ser Cys Lys Pro Ala Tyr Thr Gly Gln Asn 
    210                 215                 220                 


Cys Glu His Leu Tyr Val Pro Cys Asn Pro Ser Pro Cys Gln Asn Gly 
225                 230                 235                 240 


Gly Thr Cys Arg Gln Thr Gly Asp Thr Thr Tyr Asp Cys Thr Cys Leu 
                245                 250                 255     


Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu Asn Ile Asp Asp Cys Pro 
            260                 265                 270         


Gly Asn Asn Cys Arg Asn Gly Gly Thr Cys Val Asp Gly Val Asn Thr 
        275                 280                 285             


Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Tyr Cys Thr Glu 
    290                 295                 300                 


Asp Val Asp Glu Cys Gln Leu Met Pro Asn Ala Cys Gln Asn Gly Gly 
305                 310                 315                 320 


Thr Cys His Asn Asn His Gly Gly Tyr Asn Cys Val Cys Val Asn Gly 
                325                 330                 335     


Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala Met Ala 
            340                 345                 350         


Ala Cys Phe Gln Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr 
        355                 360                 365             


Cys Glu Cys Pro His Gly Arg Thr Gly Leu Leu Cys His Leu Asp Asp 
    370                 375                 380                 


Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys Asp Thr Asn 
385                 390                 395                 400 


Pro Val Asn Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly Tyr Met Gly 
                405                 410                 415     


Pro Ala Cys Asn Gln Asp Val Asp Glu Cys Ser Leu Gly Ala Asn Pro 
            420                 425                 430         


Cys Glu His Ala Gly Lys Cys Ile Asn Thr Gln Gly Ser Phe Gln Cys 
        435                 440                 445             


Gln Cys Leu Gln Gly Tyr Ser Gly Pro Arg Cys Glu Ile Asp Val Asn 
    450                 455                 460                 


Glu Cys Leu Ser Asn Pro Cys Gln Asn Asp Ala Thr Cys Leu Asp Gln 
465                 470                 475                 480 


Ile Gly Glu Phe Gln Cys Ile Cys Met Pro Gly Tyr Glu Gly Val Tyr 
                485                 490                 495     


Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser Ser Pro Cys Leu His Asn 
            500                 505                 510         


Gly Asn Cys Leu Asp Lys Ile Asn Glu Phe His Cys Glu Cys Pro Thr 
        515                 520                 525             


Gly Phe Asn Gly His Leu Cys Gln Phe Asp Ile Asp Glu Cys Ala Ser 
    530                 535                 540                 


Thr Pro Cys Lys Asn Gly Ala Lys Cys Val Asp Gly Pro Asn Thr Tyr 
545                 550                 555                 560 


Ser Cys Glu Cys Thr Glu Gly Phe Ser Gly Val His Cys Glu Ile Asp 
                565                 570                 575     


Ile Asp Glu Cys Asn Pro Asp Pro Cys His Tyr Gly Thr Cys Lys Asp 
            580                 585                 590         


Ser Ile Ala Ala Phe Thr Cys Leu Cys Gln Pro Gly Tyr Thr Gly His 
        595                 600                 605             


Arg Cys Asp Ile Asn Ile Asn Glu Cys Gln Ser Gln Pro Cys Arg Asn 
    610                 615                 620                 


Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala Tyr Asn Cys Leu Cys Leu 
625                 630                 635                 640 


Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala 
                645                 650                 655     


Ser Asn Pro Cys Asp Tyr Gly Lys Cys Ile Asp Lys Ile Asn Gly Tyr 
            660                 665                 670         


Glu Cys Thr Cys Glu Pro Gly Tyr Thr Gly Arg Met Cys Asn Ile Asn 
        675                 680                 685             


Ile Asp Glu Cys Ala Ser Asn Pro Cys His Asn Gly Gly Thr Cys Lys 
    690                 695                 700                 


Asp Gly Ile Asn Gly Phe Thr Cys Leu Cys Pro Glu Gly Phe His Asp 
705                 710                 715                 720 


Pro Lys Cys Leu Ser Glu Val Asn Glu Cys Asn Ser Asn Pro Cys Ile 
                725                 730                 735     


His Gly Arg Cys His Asp Gly Leu Asn Gly Tyr Arg Cys Asp Cys Asp 
            740                 745                 750         


Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu 
        755                 760                 765             


Ser Asn Pro Cys Met Asn Gly Gly Thr Cys Lys Asp Met Thr Ser Gly 
    770                 775                 780                 


Tyr Ile Cys Thr Cys Arg Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr 
785                 790                 795                 800 


Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys 
                805                 810                 815     


Ile Asp Asp Val Ala Gly Tyr Thr Cys Asn Cys Leu Leu Pro Tyr Thr 
            820                 825                 830         


Gly Ala Thr Cys Glu Asp Val Leu Ala Pro Cys Ala Gly Gly Pro Cys 
        835                 840                 845             


Lys Asn Gly Gly Glu Cys Arg Glu Ser Glu Asp Tyr Lys Arg Phe Ser 
    850                 855                 860                 


Cys Ser Cys Pro Pro Gly Trp Gln Gly Gln Thr Cys Glu Ile Asp Ile 
865                 870                 875                 880 


Asn Glu Cys Val Lys Ser Pro Cys Arg Asn Gly Ala Thr Cys Gln Asn 
                885                 890                 895     


Thr Asn Gly Ser Tyr Arg Cys Leu Cys Arg Val Gly Phe Ala Gly Arg 
            900                 905                 910         


Asn Cys Asp Thr Asp Ile Asp Asp Cys Gln Pro Asn Pro Cys His Asn 
        915                 920                 925             


Gly Gly Ser Cys Ser Asp Gly Ile Gly Thr Phe Phe Cys Glu Cys Leu 
    930                 935                 940                 


Ala Gly Phe Arg Gly Leu Lys Cys Glu Glu Asp Ile Asn Glu Cys Ala 
945                 950                 955                 960 


Ser Asn Pro Cys Lys Asn Gly Ala Asn Cys Thr Asp Cys Val Asn Ser 
                965                 970                 975     


Tyr Thr Cys Thr Cys Pro Ser Gly Phe Ser Gly Ile His Cys Glu Asn 
            980                 985                 990         


Asn Thr Pro Asp Cys Thr Glu Ser  Ser Cys Phe Asn Gly  Gly Thr Cys 
        995                 1000                 1005             


Val Asp  Gly Ile Asn Thr Phe  Thr Cys Leu Cys Pro  Ser Gly Phe 
    1010                 1015                 1020             


Thr Gly  Ser Tyr Cys Glu His  Asn Ile Asn Glu Cys  Asp Ser Lys 
    1025                 1030                 1035             


Pro Cys  Leu Asn Gly Gly Thr  Cys Gln Asp Ser Tyr  Gly Thr Tyr 
    1040                 1045                 1050             


Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly Leu Asn  Cys Gln Asn 
    1055                 1060                 1065             


Leu Val  Arg Trp Cys Asp Ser  Ser Pro Cys Lys Asn  Gly Gly Lys 
    1070                 1075                 1080             


Cys Trp  Gln Thr Asn Asn Leu  Tyr Arg Cys Glu Cys  Asn Ser Gly 
    1085                 1090                 1095             


Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser Val Ser  Cys Glu Val 
    1100                 1105                 1110             


Ala Ala  Lys Gln Gln Gly Ile  Asp Val Ala His Leu  Cys Arg Asn 
    1115                 1120                 1125             


Ser Gly  Leu Cys Val Asp Ser  Gly Asn Thr His Phe  Cys Arg Cys 
    1130                 1135                 1140             


Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu Glu Gln  Val Asp Glu 
    1145                 1150                 1155             


Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala Thr Cys  Thr Asp Tyr 
    1160                 1165                 1170             


Leu Gly  Gly Tyr Ser Cys Glu  Cys Val Ala Gly Tyr  His Gly Val 
    1175                 1180                 1185             


Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu Ser His  Pro Cys Gln 
    1190                 1195                 1200             


Asn Gly  Gly Thr Cys Ile Asp  Leu Ile Asn Thr Tyr  Lys Cys Ser 
    1205                 1210                 1215             


Cys Pro  Arg Gly Thr Gln Gly  Val His Cys Glu Ile  Asn Val Asp 
    1220                 1225                 1230             


Asp Cys  Ser Pro Phe Phe Asp  Pro Val Thr Leu Gly  Pro Lys Cys 
    1235                 1240                 1245             


Phe Asn  Asn Gly Lys Cys Thr  Asp Arg Val Gly Gly  Tyr Ser Cys 
    1250                 1255                 1260             


Ile Cys  Pro Pro Gly Phe Val  Gly Glu Arg Cys Glu  Gly Asp Val 
    1265                 1270                 1275             


Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala Arg Gly  Thr Gln Asn 
    1280                 1285                 1290             


Cys Val  Gln Arg Val Asn Asp  Tyr Lys Cys Glu Cys  Arg Pro Gly 
    1295                 1300                 1305             


Tyr Ala  Gly Arg Arg Cys Asp  Thr Val Val Asp Gly  Cys Lys Gly 
    1310                 1315                 1320             


Lys Pro  Cys Arg Asn Gly Gly  Thr Cys Ala Val Ala  Ser Asn Thr 
    1325                 1330                 1335             


Gly Arg  Gly Phe Ile Cys Lys  Cys Pro Pro Gly Phe  Val Gly Ala 
    1340                 1345                 1350             


Thr Cys  Glu Asn Asp Ser His  Thr Cys Gly Thr Leu  His Cys Leu 
    1355                 1360                 1365             


Asn Gly  Gly Thr Cys Ile Ser  Met His Lys Ser Ser  Lys Cys Val 
    1370                 1375                 1380             


Cys Ala  Ala Ala Phe Thr Gly  Pro Glu Cys Gln Tyr  Pro Ala Ser 
    1385                 1390                 1395             


Ser Pro  Cys Ile Ser Asn Pro  Cys Tyr Asn Gly Gly  Thr Cys Glu 
    1400                 1405                 1410             


Phe Leu  Ser Asp Ala Ser Pro  Tyr Tyr His Cys Asn  Cys Pro Ala 
    1415                 1420                 1425             


Asn Phe  Asn Gly Leu Asn Cys  His Ile Leu Asp Phe  Asp Phe Gln 
    1430                 1435                 1440             


Gly Gly  Phe Gly Gln Asp Ile  Ile Pro Pro Lys Ile  Glu Glu Lys 
    1445                 1450                 1455             


Cys Glu  Ile Ala Val Cys Ala  Ser Tyr Ala Gly Asn  Lys Ile Cys 
    1460                 1465                 1470             


Asp Gly  Lys Cys Asn Asn His  Ala Cys Gly Trp Asp  Gly Gly Asp 
    1475                 1480                 1485             


Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys Asn Cys  Ser Gln Ser 
    1490                 1495                 1500             


Leu Gln  Cys Trp Lys Tyr Phe  Asn Asp Gly Lys Cys  Asp Ser Gln 
    1505                 1510                 1515             


Cys Asn  Asn Ala Gly Cys Leu  Tyr Asp Gly Phe Asp  Cys Gln Lys 
    1520                 1525                 1530             


Tyr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp Gln Tyr  Cys Lys Asp 
    1535                 1540                 1545             


His Phe  Ser Asp Gly His Cys  Asp Gln Gly Cys Asn  Asn Phe Glu 
    1550                 1555                 1560             


Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Asn Asn Met  Pro Glu Lys 
    1565                 1570                 1575             


Leu Ala  Asp Gly Thr Leu Val  Val Val Val Leu Ile  Thr Pro Glu 
    1580                 1585                 1590             


Asn Leu  Lys Asn Asn Ser Phe  Asn Phe Leu Arg Glu  Leu Ser Arg 
    1595                 1600                 1605             


Val Leu  His Thr Asn Val Val  Phe Lys Lys Asn Ala  Lys Gly Glu 
    1610                 1615                 1620             


Tyr Met  Ile Phe Pro Tyr Tyr  Gly Asn Glu Glu Glu  Leu Lys Lys 
    1625                 1630                 1635             


His Tyr  Ile Lys Arg Ser Thr  Glu Asp Trp Ala Asp  Met Ser Ser 
    1640                 1645                 1650             


Ala Val  Ile Asn Lys Val Lys  Ser Ser Leu Tyr Ser  Arg Ala Gly 
    1655                 1660                 1665             


Arg Arg  Gln Lys Arg Glu Leu  Asp Gln Met Asp Ile  Arg Gly Ser 
    1670                 1675                 1680             


Ile Val  Tyr Leu Glu Ile Asp  Asn Arg Gln Cys Ile  Gln Ser Ser 
    1685                 1690                 1695             


Ser Gln  Cys Phe Gln Ser Ala  Thr Asp Val Ala Ala  Phe Leu Gly 
    1700                 1705                 1710             


Ala Leu  Ala Ser Leu Gly Asn  Leu Asn Ile Pro Tyr  Lys Ile Glu 
    1715                 1720                 1725             


Ala Val  Lys Ser Glu Thr Ala  Glu Pro Ala Arg Asn  Ser Gln Leu 
    1730                 1735                 1740             


Tyr Pro  Met Tyr Val Val Val  Ala Ala Leu Val Leu  Leu Ala Phe 
    1745                 1750                 1755             


Ile Gly  Val Gly Val Leu Val  Ser Arg Lys Arg Arg  Arg Glu His 
    1760                 1765                 1770             


Gly Gln  Leu Trp Phe Pro Glu  Gly Phe Lys Val Thr  Glu Ser Ser 
    1775                 1780                 1785             


Lys Lys  Lys Arg Arg Glu Pro  Leu Gly Glu Asp Ser  Val Gly Leu 
    1790                 1795                 1800             


Lys Pro  Leu Lys Asn Ala Ser  Asp Gly Thr Leu Met  Asp Asp Asn 
    1805                 1810                 1815             


Gln Asn  Glu Trp Gly Asp Glu  Glu Thr Leu Asp Thr  Lys Lys Phe 
    1820                 1825                 1830             


Arg Phe  Glu Glu Gln Ala Met  Leu Pro Asp Thr Asp  Asp Gln Thr 
    1835                 1840                 1845             


Asp His  Arg Gln Trp Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu 
    1850                 1855                 1860             


Arg Ile  Ser Ser Met Ala Pro  Thr Pro Pro Gln Gly  Glu Ile Asp 
    1865                 1870                 1875             


Ala Asp  Cys Met Asp Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr 
    1880                 1885                 1890             


Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly 
    1895                 1900                 1905             


Asn Ser  Glu Glu Glu Asp Asp  Ala Pro Ala Val Ile  Ser Asp Phe 
    1910                 1915                 1920             


Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly 
    1925                 1930                 1935             


Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala 
    1940                 1945                 1950             


Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp 
    1955                 1960                 1965             


Asn Met  Gly Arg Thr Pro Leu  His Ala Ala Val Ser  Ala Asp Ala 
    1970                 1975                 1980             


Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn Arg Ala  Thr Asp Leu 
    1985                 1990                 1995             


Asp Ala  Arg Met His Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala 
    2000                 2005                 2010             


Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp Leu Ile  Asn Cys His 
    2015                 2020                 2025             


Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly Lys Ser  Ala Leu His 
    2030                 2035                 2040             


Trp Ala  Ala Ala Val Asn Asn  Val Glu Ala Ala Val  Val Leu Leu 
    2045                 2050                 2055             


Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr 
    2060                 2065                 2070             


Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys 
    2075                 2080                 2085             


Val Leu  Leu Asp His Phe Ala  Asn Arg Asp Ile Thr  Asp His Met 
    2090                 2095                 2100             


Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu Arg Met  His His Asp 
    2105                 2110                 2115             


Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Pro 
    2120                 2125                 2130             


Leu His  Ser Gly Pro Leu Gly  Ala Pro Thr Leu Ser  Pro Pro Leu 
    2135                 2140                 2145             


Cys Ser  Pro Ser Ser Tyr Ile  Gly Asn Leu Lys Pro  Ala Val Gln 
    2150                 2155                 2160             


Gly Lys  Lys Ala Arg Lys Pro  Ser Thr Lys Gly Leu  Ser Cys Asn 
    2165                 2170                 2175             


Gly Lys  Asp Ser Lys Asp Leu  Lys Ala Arg Arg Lys  Lys Ser Gln 
    2180                 2185                 2190             


Asp Gly  Lys Gly Cys Leu Leu  Asp Asn Ser Ser Val  Leu Ser Pro 
    2195                 2200                 2205             


Val Asp  Ser Leu Glu Ser Pro  His Gly Tyr Leu Ser  Asp Val Ala 
    2210                 2215                 2220             


Ser Pro  Pro Leu Met Thr Ser  Pro Phe Gln Gln Ser  Pro Ser Met 
    2225                 2230                 2235             


Pro Leu  Asn His Leu Pro Gly  Met Pro Asp Ala His  Met Ser Ile 
    2240                 2245                 2250             


Asn His  Leu Asn Met Ala Gly  Lys Gln Glu Met Ala  Leu Gly Gly 
    2255                 2260                 2265             


Ser Gly  Arg Met Ala Phe Glu  Ala Val Pro Pro Arg  Leu Ser His 
    2270                 2275                 2280             


Leu Pro  Val Ser Ser Pro Ser  Thr Ala Met Ser Asn  Ala Pro Met 
    2285                 2290                 2295             


Asn Phe  Ser Val Gly Gly Ala  Ala Gly Leu Ser Gly  Gln Cys Asp 
    2300                 2305                 2310             


Trp Leu  Ser Arg Leu Gln Ser  Gly Met Val Gln Asn  Gln Tyr Gly 
    2315                 2320                 2325             


Ala Met  Arg Gly Gly Met Gln  Pro Gly Thr His Gln  Gln Ala Gln 
    2330                 2335                 2340             


Asn Leu  Gln His Gly Met Met  Ser Ser Leu His Asn  Gly Leu Pro 
    2345                 2350                 2355             


Ser Thr  Ser Leu Ser Gln Met  Met Ser Tyr Gln Ala  Met Pro Ser 
    2360                 2365                 2370             


Thr Arg  Leu Ala Ser Gln Pro  His Leu Leu Gln Asn  Gln Gln Met 
    2375                 2380                 2385             


Gln Gln  Met Gln Gln Pro Gly  Met Gln Pro Gln Pro  Gly Met Gln 
    2390                 2395                 2400             


Pro Gln  Pro Gly Met Gln Gln  Pro Gln Gln Gln Pro  Gln Gln Gln 
    2405                 2410                 2415             


Pro Gln  Pro Gln Gln His His  Asn Pro Gly Ser Asn  Ala Ser Gly 
    2420                 2425                 2430             


His Met  Gly Gln Asn Phe Leu  Gly Thr Glu Leu Ser  Gln Pro Asp 
    2435                 2440                 2445             


Met Gln  Pro Val Ser Ser Ser  Ala Met Ala Val His  Thr Ile Leu 
    2450                 2455                 2460             


Pro Gln  Asp Ser Gln Leu Leu  Pro Thr Ser Leu Pro  Ser Ser Leu 
    2465                 2470                 2475             


Ala Gln  Pro Met Thr Thr Thr  Gln Phe Leu Thr Pro  Pro Ser Gln 
    2480                 2485                 2490             


His Ser  Tyr Ser Ser Pro Leu  Asp Asn Thr Pro Ser  His Gln Leu 
    2495                 2500                 2505             


Gln Val  Pro Asp His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2510                 2515                 2520             


Asp Gln  Trp Ser Ser Ser Ser  Pro His Ser Asn Val  Ser Asp Trp 
    2525                 2530                 2535             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Ser Met Gln  Ser Gln Met 
    2540                 2545                 2550             


Gly His  Ile Pro Glu Ala Phe  Lys 
    2555                 2560     


<210>  7
<211>  2531
<212>  PRT
<213>  Rattus rattus

<400>  7

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
65                  70                  75                  80  


Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
145                 150                 155                 160 


Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
    610                 615                 620                 


Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                885                 890                 895     


Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln Tyr  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Arg Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Ser Tyr  Gly Thr Tyr Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Leu Asn  Cys Gln Asn Leu Val  Arg Trp Cys Asp Ser  Ala Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr Asn Thr Gln  Tyr His Cys 
    1070                 1075                 1080             


Glu Cys  Arg Ser Gly Trp Thr  Gly Phe Asn Cys Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Lys Arg Gly Ile  Asp Val Thr 
    1100                 1105                 1110             


Leu Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Glu  Glu Asp Lys 
    1115                 1120                 1125             


His Tyr  Cys His Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Glu  Val Asp Glu Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Phe Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Ser Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Ile Asp  Leu Thr Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  His Pro Pro Leu Asp  Pro Ala Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Thr Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Pro 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Arg Gly Lys Pro  Cys Arg Asn Gly Gly  Val Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Arg  Cys Pro Ala 
    1325                 1330                 1335             


Arg Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Ser Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Val Gly Ser Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Thr Gly Ala  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Gln Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Asn Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Leu Thr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Leu Val Val 
    1565                 1570                 1575             


Leu Leu  Pro Pro Asp Gln Leu  Arg Asn Asn Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Asp  Val Ser His Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  Gln Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ser Ala  Val Gly Trp 
    1625                 1630                 1635             


Ala Thr  Thr Ser Leu Leu Pro  Gly Thr Asn Gly Gly  Arg Gln Arg 
    1640                 1645                 1650             


Arg Glu  Leu Asp Pro Met Asp  Ile His Gly Ser Ile  Val Tyr Leu 
    1655                 1660                 1665             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Ser Ser Ser  Gln Cys Phe 
    1670                 1675                 1680             


Gln Ser  Ala Thr Asp Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser 
    1685                 1690                 1695             


Leu Gly  Ser Leu Asn Ile Pro  Tyr Lys Ile Glu Ala  Val Lys Ser 
    1700                 1705                 1710             


Glu Thr  Val Glu Pro Pro Leu  Pro Ser Gln Leu His  Leu Met Tyr 
    1715                 1720                 1725             


Val Ala  Ala Ala Ala Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly 
    1730                 1735                 1740             


Val Leu  Leu Ser Arg Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp 
    1745                 1750                 1755             


Phe Pro  Glu Gly Phe Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg 
    1760                 1765                 1770             


Arg Glu  Pro Leu Gly Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys 
    1775                 1780                 1785             


Asn Ala  Ser Asp Gly Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp 
    1790                 1795                 1800             


Gly Asp  Glu Asp Leu Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro 
    1805                 1810                 1815             


Val Val  Leu Pro Asp Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp 
    1820                 1825                 1830             


Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu Arg Val  Ser Ala Met 
    1835                 1840                 1845             


Ala Pro  Thr Pro Pro Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp 
    1850                 1855                 1860             


Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala 
    1865                 1870                 1875             


Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu 
    1880                 1885                 1890             


Glu Asp  Ala Pro Ala Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala 
    1895                 1900                 1905             


Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His 
    1910                 1915                 1920             


Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu 
    1925                 1930                 1935             


Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr 
    1940                 1945                 1950             


Pro Leu  His Ala Ala Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln 
    1955                 1960                 1965             


Ile Leu  Leu Arg Asn Arg Ala  Thr Asp Leu Asp Ala  Arg Met His 
    1970                 1975                 1980             


Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu 
    1985                 1990                 1995             


Gly Met  Leu Glu Asp Leu Ile  Asn Ser His Ala Asp  Val Asn Ala 
    2000                 2005                 2010             


Val Asp  Asp Leu Gly Lys Ser  Ala Leu His Trp Ala  Ala Ala Val 
    2015                 2020                 2025             


Asn Asn  Val Asp Ala Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn 
    2030                 2035                 2040             


Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr Pro Leu  Phe Leu Ala 
    2045                 2050                 2055             


Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His 
    2060                 2065                 2070             


Phe Ala  Asn Arg Asp Ile Thr  Asp His Met Asp Arg  Leu Pro Arg 
    2075                 2080                 2085             


Asp Ile  Ala Gln Glu Arg Met  His His Asp Ile Val  Arg Leu Leu 
    2090                 2095                 2100             


Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Gln Leu His  Gly Thr Ala 
    2105                 2110                 2115             


Leu Gly  Gly Thr Pro Thr Leu  Ser Pro Thr Leu Cys  Ser Pro Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Gly Asn Leu Lys  Ser Ala Thr Gln Gly  Lys Lys Ala 
    2135                 2140                 2145             


Arg Lys  Pro Ser Thr Lys Gly  Leu Ala Cys Ser Ser  Lys Glu Ala 
    2150                 2155                 2160             


Lys Asp  Leu Lys Ala Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly 
    2165                 2170                 2175             


Cys Leu  Leu Asp Ser Ser Ser  Met Leu Ser Pro Val  Asp Ser Leu 
    2180                 2185                 2190             


Glu Ser  Pro His Gly Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu 
    2195                 2200                 2205             


Leu Pro  Ser Pro Phe Gln Gln  Ser Pro Ser Met Pro  Leu Ser His 
    2210                 2215                 2220             


Leu Pro  Gly Met Pro Asp Thr  His Leu Gly Ile Ser  His Leu Asn 
    2225                 2230                 2235             


Val Ala  Ala Lys Pro Glu Met  Ala Ala Leu Ala Gly  Gly Ser Arg 
    2240                 2245                 2250             


Leu Ala  Phe Glu Pro Pro Pro  Pro Arg Leu Ser His  Leu Pro Val 
    2255                 2260                 2265             


Ala Ser  Ser Ala Ser Thr Val  Leu Ser Thr Asn Gly  Thr Gly Ala 
    2270                 2275                 2280             


Met Asn  Phe Thr Val Gly Ala  Pro Ala Ser Leu Asn  Gly Gln Cys 
    2285                 2290                 2295             


Glu Trp  Leu Pro Arg Leu Gln  Asn Gly Met Val Pro  Ser Gln Tyr 
    2300                 2305                 2310             


Asn Pro  Leu Arg Pro Gly Val  Thr Pro Gly Thr Leu  Ser Thr Gln 
    2315                 2320                 2325             


Ala Ala  Gly Leu Gln His Gly  Met Met Gly Pro Ile  His Ser Ser 
    2330                 2335                 2340             


Leu Ser  Thr Asn Thr Leu Ser  Pro Ile Ile Tyr Gln  Gly Leu Pro 
    2345                 2350                 2355             


Asn Thr  Arg Leu Ala Thr Gln  Pro His Leu Val Gln  Thr Gln Gln 
    2360                 2365                 2370             


Val Gln  Pro Gln Asn Leu Gln  Ile Gln Pro Gln Asn  Leu Gln Pro 
    2375                 2380                 2385             


Pro Ser  Gln Pro His Leu Ser  Val Ser Ser Ala Ala  Asn Gly His 
    2390                 2395                 2400             


Leu Gly  Arg Ser Phe Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val 
    2405                 2410                 2415             


Gln Pro  Leu Gly Pro Ser Ser  Leu Pro Val His Thr  Ile Leu Pro 
    2420                 2425                 2430             


Gln Glu  Ser Gln Ala Leu Pro  Thr Ser Leu Pro Ser  Ser Met Val 
    2435                 2440                 2445             


Pro Pro  Met Thr Thr Thr Gln  Phe Leu Thr Pro Pro  Ser Gln His 
    2450                 2455                 2460             


Ser Tyr  Ser Ser Ser Pro Val  Asp Asn Thr Pro Ser  His Gln Leu 
    2465                 2470                 2475             


Gln Val  Pro Glu His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2480                 2485                 2490             


Asp Gln  Trp Ser Ser Ser Ser  Arg His Ser Asn Ile  Ser Asp Trp 
    2495                 2500                 2505             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Ser Met Pro  Ser Gln Ile 
    2510                 2515                 2520             


Thr His  Ile Pro Glu Ala Phe  Lys 
    2525                 2530     


<210>  8
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  9
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  10
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  11
<211>  2470
<212>  PRT
<213>  Mus musculus

<400>  11

Met Pro Asp Leu Arg Pro Ala Ala Leu Arg Ala Leu Leu Trp Leu Trp 
1               5                   10                  15      


Leu Cys Gly Ala Gly Pro Ala His Ala Leu Gln Cys Arg Gly Gly Gln 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Thr Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Phe Cys Arg Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Pro Gln Gly Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Pro Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Gln Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Glu Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Ser Val Ala Ser Gln Phe Ser Cys Lys Cys Pro Ala Gly Leu Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Ala Asp Ile Asn Glu Cys Asp Ile Pro Gly Arg Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Arg Cys Gln 
        195                 200                 205             


Cys Gly Gln Gly Phe Thr Gly Gln His Cys Asp Ser Pro Tyr Val Arg 
    210                 215                 220                 


Gly Leu Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe 
225                 230                 235                 240 


Thr Leu Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu 
                245                 250                 255     


Arg Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly Gly Val 
            260                 265                 270         


Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp 
        275                 280                 285             


Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro 
    290                 295                 300                 


Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly Gly Tyr 
305                 310                 315                 320 


Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn 
                325                 330                 335     


Ile Asp Asp Cys Ala Tyr Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile 
            340                 345                 350         


Asp Arg Val Ala Ser Phe Ser Cys Leu Cys Pro Glu Gly Lys Ala Gly 
        355                 360                 365             


Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys 
    370                 375                 380                 


Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr 
385                 390                 395                 400 


Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu 
                405                 410                 415     


Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys Cys Val 
            420                 425                 430         


Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr Ala Gly 
        435                 440                 445             


Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro Cys Gln 
    450                 455                 460                 


Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys Leu Cys 
465                 470                 475                 480 


Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Val Asn Glu Cys 
                485                 490                 495     


Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys Val Asn 
            500                 505                 510         


Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val Cys Gln 
        515                 520                 525             


Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly Ala Lys 
    530                 535                 540                 


Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr Gly Phe 
545                 550                 555                 560 


Thr Gly Ile Leu Cys Asp Glu Asn Ile Asp Asn Cys Asp Pro Asp Pro 
                565                 570                 575     


Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr Cys Ile 
            580                 585                 590         


Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile Asp Glu 
        595                 600                 605             


Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp Leu Val 
    610                 615                 620                 


Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Leu Asn Cys 
625                 630                 635                 640 


Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Met His Gly Val 
                645                 650                 655     


Cys Val Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro Gly Phe 
            660                 665                 670         


Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser Asn Pro 
        675                 680                 685             


Cys Arg Lys Gly Ala Thr Cys Ile Asn Asp Val Asn Gly Phe Arg Cys 
    690                 695                 700                 


Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln Val Asn 
705                 710                 715                 720 


Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly Gly Leu 
                725                 730                 735     


Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Val Asn Cys 
            740                 745                 750         


Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn Gly Gly 
        755                 760                 765             


Thr Cys Asn Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys Lys Gly 
    770                 775                 780                 


Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala Ser Asn 
785                 790                 795                 800 


Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Val Ser Gly Tyr Thr 
                805                 810                 815     


Cys His Cys Met Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr Val Leu 
            820                 825                 830         


Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys Lys Glu 
        835                 840                 845             


Ala Pro Asn Phe Glu Ser Phe Ser Cys Leu Cys Ala Pro Gly Trp Gln 
    850                 855                 860                 


Gly Lys Arg Cys Thr Val Asp Val Asp Glu Cys Ile Ser Lys Pro Cys 
865                 870                 875                 880 


Met Asn Asn Gly Val Cys His Asn Thr Gln Gly Ser Tyr Val Cys Glu 
                885                 890                 895     


Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile Asn Asp 
            900                 905                 910         


Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp His Val 
        915                 920                 925             


Asn Thr Phe Ser Cys Gln Cys His Pro Gly Phe Ile Gly Asp Lys Cys 
    930                 935                 940                 


Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn Gly Gly 
945                 950                 955                 960 


Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Thr Cys Pro Ala Gly 
                965                 970                 975     


Phe His Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr Glu Ser 
            980                 985                 990         


Ser Cys Phe Asn Gly Gly Thr Cys  Val Asp Gly Ile Asn  Ser Phe Ser 
        995                 1000                 1005             


Cys Leu  Cys Pro Val Gly Phe  Thr Gly Pro Phe Cys  Leu His Asp 
    1010                 1015                 1020             


Ile Asn  Glu Cys Ser Ser Asn  Pro Cys Leu Asn Ala  Gly Thr Cys 
    1025                 1030                 1035             


Val Asp  Gly Leu Gly Thr Tyr  Arg Cys Ile Cys Pro  Leu Gly Tyr 
    1040                 1045                 1050             


Thr Gly  Lys Asn Cys Gln Thr  Leu Val Asn Leu Cys  Ser Arg Ser 
    1055                 1060                 1065             


Pro Cys  Lys Asn Lys Gly Thr  Cys Val Gln Glu Lys  Ala Arg Pro 
    1070                 1075                 1080             


His Cys  Leu Cys Pro Pro Gly  Trp Asp Gly Ala Tyr  Cys Asp Val 
    1085                 1090                 1095             


Leu Asn  Val Ser Cys Lys Ala  Ala Ala Leu Gln Lys  Gly Val Pro 
    1100                 1105                 1110             


Val Glu  His Leu Cys Gln His  Ser Gly Ile Cys Ile  Asn Ala Gly 
    1115                 1120                 1125             


Asn Thr  His His Cys Gln Cys  Pro Leu Gly Tyr Thr  Gly Ser Tyr 
    1130                 1135                 1140             


Cys Glu  Glu Gln Leu Asp Glu  Cys Ala Ser Asn Pro  Cys Gln His 
    1145                 1150                 1155             


Gly Ala  Thr Cys Asn Asp Phe  Ile Gly Gly Tyr Arg  Cys Glu Cys 
    1160                 1165                 1170             


Val Pro  Gly Tyr Gln Gly Val  Asn Cys Glu Tyr Glu  Val Asp Glu 
    1175                 1180                 1185             


Cys Gln  Asn Gln Pro Cys Gln  Asn Gly Gly Thr Cys  Ile Asp Leu 
    1190                 1195                 1200             


Val Asn  His Phe Lys Cys Ser  Cys Pro Pro Gly Thr  Arg Gly Leu 
    1205                 1210                 1215             


Leu Cys  Glu Glu Asn Ile Asp  Glu Cys Ala Gly Gly  Pro His Cys 
    1220                 1225                 1230             


Leu Asn  Gly Gly Gln Cys Val  Asp Arg Ile Gly Gly  Tyr Thr Cys 
    1235                 1240                 1245             


Arg Cys  Leu Pro Gly Phe Ala  Gly Glu Arg Cys Glu  Gly Asp Ile 
    1250                 1255                 1260             


Asn Glu  Cys Leu Ser Asn Pro  Cys Ser Ser Glu Gly  Ser Leu Asp 
    1265                 1270                 1275             


Cys Val  Gln Leu Lys Asn Asn  Tyr Asn Cys Ile Cys  Arg Ser Ala 
    1280                 1285                 1290             


Phe Thr  Gly Arg His Cys Glu  Thr Phe Leu Asp Val  Cys Pro Gln 
    1295                 1300                 1305             


Lys Pro  Cys Leu Asn Gly Gly  Thr Cys Ala Val Ala  Ser Asn Met 
    1310                 1315                 1320             


Pro Asp  Gly Phe Ile Cys Arg  Cys Pro Pro Gly Phe  Ser Gly Ala 
    1325                 1330                 1335             


Arg Leu  Gln Ser Ser Cys Gly  Gln Val Lys Cys Arg  Arg Gly Glu 
    1340                 1345                 1350             


Gln Cys  Ile His Thr Asp Ser  Gly Pro Arg Cys Phe  Cys Leu Asn 
    1355                 1360                 1365             


Pro Lys  Asp Cys Glu Ser Gly  Cys Ala Ser Asn Pro  Cys Gln His 
    1370                 1375                 1380             


Gly Gly  Thr Cys Tyr Pro Gln  Arg Gln Pro Pro His  Tyr Ser Cys 
    1385                 1390                 1395             


Arg Cys  Pro Pro Ser Phe Gly  Gly Ser His Cys Glu  Leu Tyr Thr 
    1400                 1405                 1410             


Ala Pro  Thr Ser Thr Pro Pro  Ala Thr Cys Gln Ser  Gln Tyr Cys 
    1415                 1420                 1425             


Ala Asp  Lys Ala Arg Asp Gly  Ile Cys Asp Glu Ala  Cys Asn Ser 
    1430                 1435                 1440             


His Ala  Cys Gln Trp Asp Gly  Gly Asp Cys Ser Leu  Thr Met Glu 
    1445                 1450                 1455             


Asp Pro  Trp Ala Asn Cys Thr  Ser Thr Leu Arg Cys  Trp Glu Tyr 
    1460                 1465                 1470             


Ile Asn  Asn Gln Cys Asp Glu  Gln Cys Asn Thr Ala  Glu Cys Leu 
    1475                 1480                 1485             


Phe Asp  Asn Phe Glu Cys Gln  Arg Asn Ser Lys Thr  Cys Lys Tyr 
    1490                 1495                 1500             


Asp Lys  Tyr Cys Ala Asp His  Phe Lys Asp Asn His  Cys Asp Gln 
    1505                 1510                 1515             


Gly Cys  Asn Ser Glu Glu Cys  Gly Trp Asp Gly Leu  Asp Cys Ala 
    1520                 1525                 1530             


Ser Asp  Gln Pro Glu Asn Leu  Ala Glu Gly Thr Leu  Ile Ile Val 
    1535                 1540                 1545             


Val Leu  Leu Pro Pro Glu Gln  Leu Leu Gln Asp Ser  Arg Ser Phe 
    1550                 1555                 1560             


Leu Arg  Ala Leu Gly Thr Leu  Leu His Thr Asn Leu  Arg Ile Lys 
    1565                 1570                 1575             


Gln Asp  Ser Gln Gly Ala Leu  Met Val Tyr Pro Tyr  Phe Gly Glu 
    1580                 1585                 1590             


Lys Ser  Ala Ala Met Lys Lys  Gln Lys Met Thr Arg  Arg Ser Leu 
    1595                 1600                 1605             


Pro Glu  Glu Gln Glu Gln Glu  Gln Glu Val Ile Gly  Ser Lys Ile 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp Gln 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Phe Ser 
    1655                 1660                 1665             


Glu Leu  Glu Ser Pro Arg Asn  Ala Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Phe Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Gln Ala  Trp Leu Pro Leu Ala  Ala Gly Arg 
    1700                 1705                 1710             


Phe Thr  Leu Arg Arg Asp Ser  Ser Asn His Lys Arg  Arg Glu Pro 
    1715                 1720                 1725             


Val Gly  Gln Asp Ala Val Gly  Leu Lys Asn Leu Ser  Val Gln Val 
    1730                 1735                 1740             


Ser Glu  Ala Asn Leu Ile Gly  Ser Gly Thr Ser Glu  His Trp Val 
    1745                 1750                 1755             


Asp Asp  Glu Gly Pro Gln Pro  Lys Lys Ala Lys Ala  Glu Asp Glu 
    1760                 1765                 1770             


Ala Leu  Leu Ser Glu Asp Asp  Pro Ile Asp Arg Arg  Pro Trp Thr 
    1775                 1780                 1785             


Gln Gln  His Leu Glu Ala Ala  Asp Ile Ser His Thr  Pro Ser Leu 
    1790                 1795                 1800             


Ala Leu  Thr Pro Pro Gln Ala  Glu Gln Glu Val Asp  Val Leu Asp 
    1805                 1810                 1815             


Val Asn  Val Arg Gly Pro Asp  Gly Cys Thr Pro Leu  Met Leu Ala 
    1820                 1825                 1830             


Ser Leu  Arg Gly Gly Ser Ser  Asp Leu Ser Asp Glu  Asp Glu Asp 
    1835                 1840                 1845             


Ala Glu  Asp Ser Ser Ala Asn  Ile Ile Thr Asp Leu  Val Tyr Gln 
    1850                 1855                 1860             


Gly Ala  Ser Leu Gln Ala Gln  Thr Asp Arg Thr Gly  Glu Met Ala 
    1865                 1870                 1875             


Leu His  Leu Ala Ala Arg Tyr  Ser Arg Ala Asp Ala  Ala Lys Arg 
    1880                 1885                 1890             


Leu Leu  Asp Ala Gly Ala Asp  Arg Asn Ala Gln Asp  Asn Met Gly 
    1895                 1900                 1905             


Arg Cys  Pro Leu His Ala Ala  Val Ala Gly Asp Ala  Gln Gly Val 
    1910                 1915                 1920             


Phe Gln  Ile Leu Ile Arg Asn  Arg Val Thr Asp Leu  Asp Ala Arg 
    1925                 1930                 1935             


Met Asn  Asp Gly Thr Thr Pro  Leu Ile Leu Ala Ala  Arg Leu Ala 
    1940                 1945                 1950             


Val Glu  Gly Met Val Ala Glu  Leu Ile Asn Cys Gln  Ala Asp Val 
    1955                 1960                 1965             


Asn Ala  Val Asp Asp His Gly  Lys Ser Ala Leu His  Trp Ala Ala 
    1970                 1975                 1980             


Ala Val  Asn Asn Val Glu Ala  Thr Leu Leu Leu Leu  Lys Asn Gly 
    1985                 1990                 1995             


Ala Asn  Arg Asp Met Gln Asp  Asn Lys Glu Glu Thr  Pro Leu Phe 
    2000                 2005                 2010             


Leu Ala  Ala Arg Glu Gly Ser  Tyr Glu Ala Ala Lys  Ile Leu Leu 
    2015                 2020                 2025             


Asp His  Phe Ala Asn Arg Asp  Ile Thr Asp His Met  Asp Arg Leu 
    2030                 2035                 2040             


Pro Arg  Asp Val Ala Arg Asp  Arg Met His His Asp  Ile Val Arg 
    2045                 2050                 2055             


Leu Leu  Asp Glu Tyr Asn Val  Thr Pro Ser Pro Pro  Gly Thr Val 
    2060                 2065                 2070             


Leu Thr  Ser Ala Leu Ser Pro  Val Leu Cys Gly Pro  Asn Arg Ser 
    2075                 2080                 2085             


Phe Leu  Ser Leu Lys His Thr  Pro Met Gly Lys Lys  Ala Arg Arg 
    2090                 2095                 2100             


Pro Asn  Thr Lys Ser Thr Met  Pro Thr Ser Leu Pro  Asn Leu Ala 
    2105                 2110                 2115             


Lys Glu  Ala Lys Asp Ala Lys  Gly Ser Arg Arg Lys  Lys Cys Leu 
    2120                 2125                 2130             


Asn Glu  Lys Val Gln Leu Ser  Glu Ser Ser Val Thr  Leu Ser Pro 
    2135                 2140                 2145             


Val Asp  Ser Leu Glu Ser Pro  His Thr Tyr Val Ser  Asp Ala Thr 
    2150                 2155                 2160             


Ser Ser  Pro Met Ile Thr Ser  Pro Gly Ile Leu Gln  Ala Ser Pro 
    2165                 2170                 2175             


Thr Pro  Leu Leu Ala Ala Ala  Ala Pro Ala Ala Pro  Val His Thr 
    2180                 2185                 2190             


Gln His  Ala Leu Ser Phe Ser  Asn Leu His Asp Met  Gln Pro Leu 
    2195                 2200                 2205             


Ala Pro  Gly Ala Ser Thr Val  Leu Pro Ser Val Ser  Gln Leu Leu 
    2210                 2215                 2220             


Ser His  His His Ile Ala Pro  Pro Gly Ser Ser Ser  Ala Gly Ser 
    2225                 2230                 2235             


Leu Gly  Arg Leu His Pro Val  Pro Val Pro Ala Asp  Trp Met Asn 
    2240                 2245                 2250             


Arg Val  Glu Met Asn Glu Thr  Gln Tyr Ser Glu Met  Phe Gly Met 
    2255                 2260                 2265             


Val Leu  Ala Pro Ala Glu Gly  Ala His Pro Gly Ile  Ala Ala Pro 
    2270                 2275                 2280             


Gln Ser  Arg Pro Pro Glu Gly  Lys His Met Ser Thr  Gln Arg Glu 
    2285                 2290                 2295             


Pro Leu  Pro Pro Ile Val Thr  Phe Gln Leu Ile Pro  Lys Arg Ser 
    2300                 2305                 2310             


Ile Ala  Gln Ala Ala Gly Ala  Pro Gln Thr Gln Ser  Ser Cys Pro 
    2315                 2320                 2325             


Pro Ala  Val Ala Gly Pro Leu  Pro Ser Met Tyr Gln  Ile Pro Glu 
    2330                 2335                 2340             


Met Pro  Arg Leu Pro Ser Val  Ala Phe Pro Pro Thr  Met Met Pro 
    2345                 2350                 2355             


Gln Gln  Glu Gly Gln Val Ala  Gln Thr Ile Val Pro  Thr Tyr His 
    2360                 2365                 2370             


Pro Phe  Pro Ala Ser Val Gly  Lys Tyr Pro Thr Pro  Pro Ser Gln 
    2375                 2380                 2385             


His Ser  Tyr Ala Ser Ser Asn  Ala Ala Glu Arg Thr  Pro Ser His 
    2390                 2395                 2400             


Gly Gly  His Leu Gln Gly Glu  His Pro Tyr Leu Thr  Pro Ser Pro 
    2405                 2410                 2415             


Glu Ser  Pro Asp Gln Trp Ser  Ser Ser Ser Pro His  Ser Ala Ser 
    2420                 2425                 2430             


Asp Trp  Ser Asp Val Thr Thr  Ser Pro Thr Pro Gly  Gly Gly Gly 
    2435                 2440                 2445             


Gly Gly  Gln Arg Gly Pro Gly  Thr His Met Ser Glu  Pro Pro His 
    2450                 2455                 2460             


Ser Asn  Met Gln Val Tyr Ala  
    2465                 2470 


<210>  12
<211>  1964
<212>  PRT
<213>  Mus musculus

<400>  12

Met Gln Pro Gln Leu Leu Leu Leu Leu Leu Leu Pro Leu Asn Phe Pro 
1               5                   10                  15      


Val Ile Leu Thr Arg Glu Leu Leu Cys Gly Gly Ser Pro Glu Pro Cys 
            20                  25                  30          


Ala Asn Gly Gly Thr Cys Leu Arg Leu Ser Gln Gly Gln Gly Ile Cys 
        35                  40                  45              


Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe Pro Asp Pro 
    50                  55                  60                  


Cys Arg Asp Thr Gln Leu Cys Lys Asn Gly Gly Ser Cys Gln Ala Leu 
65                  70                  75                  80  


Leu Pro Thr Pro Pro Ser Ser Arg Ser Pro Thr Ser Pro Leu Thr Pro 
                85                  90                  95      


His Phe Ser Cys Thr Cys Pro Ser Gly Phe Thr Gly Asp Arg Cys Gln 
            100                 105                 110         


Thr His Leu Glu Glu Leu Cys Pro Pro Ser Phe Cys Ser Asn Gly Gly 
        115                 120                 125             


His Cys Tyr Val Gln Ala Ser Gly Arg Pro Gln Cys Ser Cys Glu Pro 
    130                 135                 140                 


Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys Ser Ala Asn 
145                 150                 155                 160 


Pro Cys Ala Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro Gln Ile Gln 
                165                 170                 175     


Cys Arg Cys Pro Pro Gly Phe Glu Gly His Thr Cys Glu Arg Asp Ile 
            180                 185                 190         


Asn Glu Cys Phe Leu Glu Pro Gly Pro Cys Pro Gln Gly Thr Ser Cys 
        195                 200                 205             


His Asn Thr Leu Gly Ser Tyr Gln Cys Leu Cys Pro Val Gly Gln Glu 
    210                 215                 220                 


Gly Pro Gln Cys Lys Leu Arg Lys Gly Ala Cys Pro Pro Gly Ser Cys 
225                 230                 235                 240 


Leu Asn Gly Gly Thr Cys Gln Leu Val Pro Glu Gly His Ser Thr Phe 
                245                 250                 255     


His Leu Cys Leu Cys Pro Pro Gly Phe Thr Gly Leu Asp Cys Glu Met 
            260                 265                 270         


Asn Pro Asp Asp Cys Val Arg His Gln Cys Gln Asn Gly Ala Thr Cys 
        275                 280                 285             


Leu Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Lys Thr Trp Lys 
    290                 295                 300                 


Gly Trp Asp Cys Ser Glu Asp Ile Asp Glu Cys Glu Ala Arg Gly Pro 
305                 310                 315                 320 


Pro Arg Cys Arg Asn Gly Gly Thr Cys Gln Asn Thr Ala Gly Ser Phe 
                325                 330                 335     


His Cys Val Cys Val Ser Gly Trp Gly Gly Ala Gly Cys Glu Glu Asn 
            340                 345                 350         


Leu Asp Asp Cys Ala Ala Ala Thr Cys Ala Pro Gly Ser Thr Cys Ile 
        355                 360                 365             


Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly Arg Thr Gly 
    370                 375                 380                 


Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro Cys His Val 
385                 390                 395                 400 


Asn Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr Leu Cys Ile 
                405                 410                 415     


Cys Gln Pro Gly Tyr Ser Gly Ser Thr Cys His Gln Asp Leu Asp Glu 
            420                 425                 430         


Cys Gln Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His Gly Gly Ser 
        435                 440                 445             


Cys Ile Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Leu Pro Gly Tyr 
    450                 455                 460                 


Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu Ser Gln Pro 
465                 470                 475                 480 


Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr Phe His Cys 
                485                 490                 495     


Leu Cys Pro Pro Gly Leu Glu Gly Arg Leu Cys Glu Val Glu Val Asn 
            500                 505                 510         


Glu Cys Thr Ser Asn Pro Cys Leu Asn Gln Ala Ala Cys His Asp Leu 
        515                 520                 525             


Leu Asn Gly Phe Gln Cys Leu Cys Leu Pro Gly Phe Thr Gly Ala Arg 
    530                 535                 540                 


Cys Glu Lys Asp Met Asp Glu Cys Ser Ser Thr Pro Cys Ala Asn Gly 
545                 550                 555                 560 


Gly Arg Cys Arg Asp Gln Pro Gly Ala Phe Tyr Cys Glu Cys Leu Pro 
                565                 570                 575     


Gly Phe Glu Gly Pro His Cys Glu Lys Glu Val Asp Glu Cys Leu Ser 
            580                 585                 590         


Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro Gly Ala Phe 
        595                 600                 605             


Phe Cys Leu Cys Arg Pro Gly Phe Thr Gly Gln Leu Cys Glu Val Pro 
    610                 615                 620                 


Leu Cys Thr Pro Asn Met Cys Gln Pro Gly Gln Gln Cys Gln Gly Gln 
625                 630                 635                 640 


Glu His Arg Ala Pro Cys Leu Cys Pro Asp Gly Ser Pro Gly Cys Val 
                645                 650                 655     


Pro Ala Glu Asp Asn Cys Pro Cys His His Gly His Cys Gln Arg Ser 
            660                 665                 670         


Leu Cys Val Cys Asp Glu Gly Trp Thr Gly Pro Glu Cys Glu Thr Glu 
        675                 680                 685             


Leu Gly Gly Cys Ile Ser Thr Pro Cys Ala His Gly Gly Thr Cys His 
    690                 695                 700                 


Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Ala Gly Tyr Met Gly 
705                 710                 715                 720 


Leu Thr Cys Ser Glu Glu Val Thr Ala Cys His Ser Gly Pro Cys Leu 
                725                 730                 735     


Asn Gly Gly Ser Cys Ser Ile Arg Pro Glu Gly Tyr Ser Cys Thr Cys 
            740                 745                 750         


Leu Pro Ser His Thr Gly Arg His Cys Gln Thr Ala Val Asp His Cys 
        755                 760                 765             


Val Ser Ala Ser Cys Leu Asn Gly Gly Thr Cys Val Asn Lys Pro Gly 
    770                 775                 780                 


Thr Phe Phe Cys Leu Cys Ala Thr Gly Phe Gln Gly Leu His Cys Glu 
785                 790                 795                 800 


Glu Lys Thr Asn Pro Ser Cys Ala Asp Ser Pro Cys Arg Asn Lys Ala 
                805                 810                 815     


Thr Cys Gln Asp Thr Pro Arg Gly Ala Arg Cys Leu Cys Ser Pro Gly 
            820                 825                 830         


Tyr Thr Gly Ser Ser Cys Gln Thr Leu Ile Asp Leu Cys Ala Arg Lys 
        835                 840                 845             


Pro Cys Pro His Thr Ala Arg Cys Leu Gln Ser Gly Pro Ser Phe Gln 
    850                 855                 860                 


Cys Leu Cys Leu Gln Gly Trp Thr Gly Ala Leu Cys Asp Phe Pro Leu 
865                 870                 875                 880 


Ser Cys Gln Met Ala Ala Met Ser Gln Gly Ile Glu Ile Ser Gly Leu 
                885                 890                 895     


Cys Gln Asn Gly Gly Leu Cys Ile Asp Thr Gly Ser Ser Tyr Phe Cys 
            900                 905                 910         


Arg Cys Pro Pro Gly Phe Gln Gly Lys Leu Cys Gln Asp Asn Met Asn 
        915                 920                 925             


Pro Cys Glu Pro Asn Pro Cys His His Gly Ser Thr Cys Val Pro Gln 
    930                 935                 940                 


Pro Ser Gly Tyr Val Cys Gln Cys Ala Pro Gly Tyr Glu Gly Gln Asn 
945                 950                 955                 960 


Cys Ser Lys Val Leu Glu Ala Cys Gln Ser Gln Pro Cys His Asn His 
                965                 970                 975     


Gly Thr Cys Thr Ser Arg Pro Gly Gly Phe His Cys Ala Cys Pro Pro 
            980                 985                 990         


Gly Phe Val Gly Leu Arg Cys Glu  Gly Asp Val Asp Glu  Cys Leu Asp 
        995                 1000                 1005             


Arg Pro  Cys His Pro Ser Gly  Thr Ala Ala Cys His  Ser Leu Ala 
    1010                 1015                 1020             


Asn Ala  Phe Tyr Cys Gln Cys  Leu Pro Gly His Thr  Gly Gln Arg 
    1025                 1030                 1035             


Cys Glu  Val Glu Met Asp Leu  Cys Gln Ser Gln Pro  Cys Ser Asn 
    1040                 1045                 1050             


Gly Gly  Ser Cys Glu Ile Thr  Thr Gly Pro Pro Pro  Gly Phe Thr 
    1055                 1060                 1065             


Cys His  Cys Pro Lys Gly Phe  Glu Gly Pro Thr Cys  Ser His Lys 
    1070                 1075                 1080             


Ala Leu  Ser Cys Gly Ile His  His Cys His Asn Gly  Gly Leu Cys 
    1085                 1090                 1095             


Leu Pro  Ser Pro Lys Pro Gly  Ser Pro Pro Leu Cys  Ala Cys Leu 
    1100                 1105                 1110             


Ser Gly  Phe Gly Gly Pro Asp  Cys Leu Thr Pro Pro  Ala Pro Pro 
    1115                 1120                 1125             


Gly Cys  Gly Pro Pro Ser Pro  Cys Leu His Asn Gly  Thr Cys Thr 
    1130                 1135                 1140             


Glu Thr  Pro Gly Leu Gly Asn  Pro Gly Phe Gln Cys  Thr Cys Pro 
    1145                 1150                 1155             


Pro Asp  Ser Pro Gly Pro Arg  Cys Gln Arg Pro Gly  Ala Ser Gly 
    1160                 1165                 1170             


Cys Glu  Gly Arg Gly Gly Asp  Gly Thr Cys Asp Ala  Gly Cys Ser 
    1175                 1180                 1185             


Gly Pro  Gly Gly Asp Trp Asp  Gly Gly Asp Cys Ser  Leu Gly Val 
    1190                 1195                 1200             


Pro Asp  Pro Trp Lys Gly Cys  Pro Pro His Ser Gln  Cys Trp Leu 
    1205                 1210                 1215             


Leu Phe  Arg Asp Gly Arg Cys  His Pro Gln Cys Asp  Ser Glu Glu 
    1220                 1225                 1230             


Cys Leu  Phe Asp Gly Tyr Asp  Cys Glu Ile Pro Leu  Thr Cys Ile 
    1235                 1240                 1245             


Pro Ala  Tyr Asp Gln Tyr Cys  Arg Asp His Phe His  Asn Gly His 
    1250                 1255                 1260             


Cys Glu  Lys Gly Cys Asn Asn  Ala Glu Cys Gly Trp  Asp Gly Gly 
    1265                 1270                 1275             


Asp Cys  Arg Pro Glu Gly Glu  Asp Ser Glu Gly Arg  Pro Ser Leu 
    1280                 1285                 1290             


Ala Leu  Leu Val Val Leu Arg  Pro Pro Ala Leu Asp  Gln Gln Leu 
    1295                 1300                 1305             


Leu Ala  Leu Ala Arg Val Leu  Ser Leu Thr Leu Arg  Val Gly Leu 
    1310                 1315                 1320             


Trp Val  Arg Lys Asp Ser Glu  Gly Arg Asn Met Val  Phe Pro Tyr 
    1325                 1330                 1335             


Pro Gly  Thr Arg Ala Lys Glu  Glu Leu Ser Gly Ala  Arg Asp Ser 
    1340                 1345                 1350             


Ser Ser  Trp Glu Arg Gln Ala  Pro Pro Thr Gln Pro  Leu Gly Lys 
    1355                 1360                 1365             


Glu Thr  Glu Ser Leu Gly Ala  Gly Phe Val Val Val  Met Gly Val 
    1370                 1375                 1380             


Asp Leu  Ser Arg Cys Gly Pro  Glu His Pro Ala Ser  Arg Cys Pro 
    1385                 1390                 1395             


Trp Asp  Ser Gly Leu Leu Leu  Arg Phe Leu Ala Ala  Met Ala Ala 
    1400                 1405                 1410             


Val Gly  Ala Leu Glu Pro Leu  Leu Pro Gly Pro Leu  Leu Ala Ala 
    1415                 1420                 1425             


His Pro  Gln Ala Gly Thr Arg  Pro Pro Ala Asn Gln  Leu Pro Trp 
    1430                 1435                 1440             


Pro Ile  Leu Cys Ser Pro Val  Val Gly Val Leu Leu  Leu Ala Leu 
    1445                 1450                 1455             


Gly Ala  Leu Leu Val Leu Gln  Leu Ile Arg Arg Arg  Arg Arg Glu 
    1460                 1465                 1470             


His Gly  Ala Leu Trp Leu Pro  Pro Gly Phe Ile Arg  Arg Pro Gln 
    1475                 1480                 1485             


Ala Gln  Gln Ala Pro His Arg  Arg Arg Pro Pro Leu  Gly Glu Asp 
    1490                 1495                 1500             


Asn Ile  Gly Leu Lys Ala Leu  Lys Pro Glu Ala Glu  Val Asp Glu 
    1505                 1510                 1515             


Asp Gly  Val Ala Met Cys Ser  Gly Pro Glu Glu Gly  Glu Ala Glu 
    1520                 1525                 1530             


Glu Thr  Ala Ser Ala Ser Arg  Cys Gln Leu Trp Pro  Leu Asn Ser 
    1535                 1540                 1545             


Ser Cys  Gly Glu Leu Pro Gln  Ala Ala Met Leu Thr  Pro Pro Gln 
    1550                 1555                 1560             


Glu Cys  Glu Ser Glu Val Leu  Asp Val Asp Thr Cys  Gly Pro Asp 
    1565                 1570                 1575             


Gly Val  Thr Pro Leu Met Ser  Ala Val Phe Cys Gly  Gly Val Gln 
    1580                 1585                 1590             


Ser Thr  Thr Gly Ala Ser Pro  Gln Arg Leu Gly Leu  Gly Asn Leu 
    1595                 1600                 1605             


Glu Pro  Trp Glu Pro Leu Leu  Asp Arg Gly Ala Cys  Pro Gln Ala 
    1610                 1615                 1620             


His Thr  Val Gly Thr Gly Glu  Thr Pro Leu His Leu  Ala Ala Arg 
    1625                 1630                 1635             


Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu Leu Glu  Ala Gly Ala 
    1640                 1645                 1650             


Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg Thr Pro  Leu His Thr 
    1655                 1660                 1665             


Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys Gln Leu  Leu Leu Ala 
    1670                 1675                 1680             


Ser Arg  Gln Thr Ser Val Asp  Ala Arg Thr Glu Asp  Gly Thr Thr 
    1685                 1690                 1695             


Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val Glu Asp  Leu Val Glu 
    1700                 1705                 1710             


Glu Leu  Ile Ala Ala Arg Ala  Asp Val Gly Ala Arg  Asp Lys Arg 
    1715                 1720                 1725             


Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Ala Arg 
    1730                 1735                 1740             


Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala Asp Lys  Asp Ala Gln 
    1745                 1750                 1755             


Asp Ser  Arg Glu Gln Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1760                 1765                 1770             


Ala Val  Glu Val Ala Gln Leu  Leu Leu Glu Leu Gly  Ala Ala Arg 
    1775                 1780                 1785             


Gly Leu  Arg Asp Gln Ala Gly  Leu Ala Pro Gly Asp  Val Ala Arg 
    1790                 1795                 1800             


Gln Arg  Ser His Trp Asp Leu  Leu Thr Leu Leu Glu  Gly Ala Gly 
    1805                 1810                 1815             


Pro Thr  Thr Gln Glu Ala Arg  Ala His Ala Arg Thr  Thr Pro Gly 
    1820                 1825                 1830             


Gly Gly  Ala Ala Ala Arg Cys  Arg Thr Leu Ser Ala  Gly Ala Arg 
    1835                 1840                 1845             


Pro Arg  Gly Gly Gly Ala Cys  Leu Gln Ala Arg Thr  Trp Ser Val 
    1850                 1855                 1860             


Asp Leu  Gly Ala Arg Gly Gly  Lys Val Tyr Ala Arg  Cys Arg Ser 
    1865                 1870                 1875             


Arg Ser  Gly Ser Cys Gly Gly  Pro Thr Thr Arg Gly  Arg Arg Phe 
    1880                 1885                 1890             


Ser Ala  Gly Ser Arg Gly Arg  Arg Gly Ala Arg Ala  Ser Gln Asp 
    1895                 1900                 1905             


Asp Trp  Pro Arg Asp Trp Val  Ala Leu Glu Ala Cys  Gly Ser Ala 
    1910                 1915                 1920             


Cys Ser  Ala Pro Ile Pro Pro  Pro Ser Leu Thr Pro  Ser Pro Glu 
    1925                 1930                 1935             


Arg Gly  Ser Pro Gln Val Ala  Trp Gly Leu Pro Val  His Gln Glu 
    1940                 1945                 1950             


Ile Pro  Leu Asn Ser Val Val  Arg Asn Leu Asn 
    1955                 1960                 


<210>  13
<211>  2318
<212>  PRT
<213>  Mus musculus

<400>  13

Met Gly Leu Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Leu Met Ala 
1               5                   10                  15      


Leu Pro Pro Pro Pro Pro Pro Met Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Leu Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr His Gln Gln Pro Ser Leu Glu Ala 
    50                  55                  60                  


Ala Cys Leu Cys Leu Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu 
65                  70                  75                  80  


Asp Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser 
                85                  90                  95      


Ser Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Leu Arg Gly 
            100                 105                 110         


Phe Gln Gly Pro Asp Cys Ser Gln Pro Asp Pro Cys Val Ser Arg Pro 
        115                 120                 125             


Cys Val His Gly Ala Pro Cys Ser Val Gly Pro Asp Gly Arg Phe Ala 
    130                 135                 140                 


Cys Ala Cys Pro Pro Gly Tyr Gln Gly Gln Ser Cys Gln Ser Asp Ile 
145                 150                 155                 160 


Asp Glu Cys Arg Ser Gly Thr Thr Cys Arg His Gly Gly Thr Cys Leu 
                165                 170                 175     


Asn Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Leu Gly Tyr Thr Gly 
            180                 185                 190         


Leu Leu Cys Glu Asn Pro Val Val Pro Cys Ala Pro Ser Pro Cys Arg 
        195                 200                 205             


Asn Gly Gly Thr Cys Arg Gln Ser Ser Asp Val Thr Tyr Asp Cys Ala 
    210                 215                 220                 


Cys Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp 
225                 230                 235                 240 


Cys Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val 
                245                 250                 255     


Asn Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys 
            260                 265                 270         


Thr Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn 
        275                 280                 285             


Gly Gly Thr Cys Phe Asn Leu Leu Gly Gly His Ser Cys Val Cys Val 
    290                 295                 300                 


Asn Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala 
305                 310                 315                 320 


Thr Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser 
                325                 330                 335     


Phe Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu 
            340                 345                 350         


Asp Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp 
        355                 360                 365             


Thr Asn Pro Val Ser Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe 
    370                 375                 380                 


Thr Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala 
385                 390                 395                 400 


Asn Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe 
                405                 410                 415     


Leu Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp 
            420                 425                 430         


Val Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu 
        435                 440                 445             


Asp Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly 
    450                 455                 460                 


Thr Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val 
465                 470                 475                 480 


Asn Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys 
                485                 490                 495     


Pro Ser Gly Phe Ser Gly Ser Met Cys Gln Leu Asp Val Asp Glu Cys 
            500                 505                 510         


Ala Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp 
        515                 520                 525             


Gly Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Glu 
    530                 535                 540                 


Arg Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys 
545                 550                 555                 560 


Val Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr 
                565                 570                 575     


Gly Ile Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys 
            580                 585                 590         


Arg Tyr Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg 
        595                 600                 605             


Cys Pro Pro Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp 
    610                 615                 620                 


Cys Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn 
625                 630                 635                 640 


Arg Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn 
                645                 650                 655     


Val Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser 
            660                 665                 670         


Cys Val Asp Gly Glu Asn Gly Phe His Cys Leu Cys Pro Pro Gly Ser 
        675                 680                 685             


Leu Pro Pro Leu Cys Leu Pro Ala Asn His Pro Cys Ala His Lys Pro 
    690                 695                 700                 


Cys Ser His Gly Val Cys His Asp Ala Pro Gly Gly Phe Arg Cys Val 
705                 710                 715                 720 


Cys Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Pro 
                725                 730                 735     


Asp Ala Cys Glu Ser Gln Pro Cys Gln Ala Gly Gly Thr Cys Thr Ser 
            740                 745                 750         


Asp Gly Ile Gly Phe Arg Cys Thr Cys Ala Pro Gly Phe Gln Gly His 
        755                 760                 765             


Gln Cys Glu Val Leu Ser Pro Cys Thr Pro Ser Leu Cys Glu His Gly 
    770                 775                 780                 


Gly His Cys Glu Ser Asp Pro Asp Arg Leu Thr Val Cys Ser Cys Pro 
785                 790                 795                 800 


Pro Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala 
                805                 810                 815     


Gly Ala Ser Pro Cys Gly Pro His Gly Thr Cys Thr Asn Leu Pro Gly 
            820                 825                 830         


Asn Phe Arg Cys Ile Cys His Arg Gly Tyr Thr Gly Pro Phe Cys Asp 
        835                 840                 845             


Gln Asp Ile Asp Asp Cys Asp Pro Asn Pro Cys Leu His Gly Gly Ser 
    850                 855                 860                 


Cys Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Asp Gly Phe 
865                 870                 875                 880 


Ala Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Ser Pro 
                885                 890                 895     


Cys Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Ala 
            900                 905                 910         


Cys Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Ile Asp Leu Pro Asp 
        915                 920                 925             


Cys Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val 
    930                 935                 940                 


Ser Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Thr His Cys 
945                 950                 955                 960 


Gln Tyr Glu Ala Asp Pro Cys Phe Ser Arg Pro Cys Leu His Gly Gly 
                965                 970                 975     


Ile Cys Asn Pro Thr His Pro Gly Phe Glu Cys Thr Cys Arg Glu Gly 
            980                 985                 990         


Phe Thr Gly Ser Gln Cys Gln Asn  Pro Val Asp Trp Cys  Ser Gln Ala 
        995                 1000                 1005             


Pro Cys  Gln Asn Gly Gly Arg  Cys Val Gln Thr Gly  Ala Tyr Cys 
    1010                 1015                 1020             


Ile Cys  Pro Pro Gly Trp Ser  Gly Arg Leu Cys Asp  Ile Gln Ser 
    1025                 1030                 1035             


Leu Pro  Cys Thr Glu Ala Ala  Ala Gln Met Gly Val  Arg Leu Glu 
    1040                 1045                 1050             


Gln Leu  Cys Gln Glu Gly Gly  Lys Cys Ile Asp Lys  Gly Arg Ser 
    1055                 1060                 1065             


His Tyr  Cys Val Cys Pro Glu  Gly Arg Thr Gly Ser  His Cys Glu 
    1070                 1075                 1080             


His Glu  Val Asp Pro Cys Thr  Ala Gln Pro Cys Gln  His Gly Gly 
    1085                 1090                 1095             


Thr Cys  Arg Gly Tyr Met Gly  Gly Tyr Val Cys Glu  Cys Pro Ala 
    1100                 1105                 1110             


Gly Tyr  Ala Gly Asp Ser Cys  Glu Asp Asn Ile Asp  Glu Cys Ala 
    1115                 1120                 1125             


Ser Gln  Pro Cys Gln Asn Gly  Gly Ser Cys Ile Asp  Leu Val Ala 
    1130                 1135                 1140             


Arg Tyr  Leu Cys Ser Cys Pro  Pro Gly Thr Leu Gly  Val Leu Cys 
    1145                 1150                 1155             


Glu Ile  Asn Glu Asp Asp Cys  Asp Leu Gly Pro Ser  Leu Asp Ser 
    1160                 1165                 1170             


Gly Val  Gln Cys Leu His Asn  Gly Thr Cys Val Asp  Leu Val Gly 
    1175                 1180                 1185             


Gly Phe  Arg Cys Asn Cys Pro  Pro Gly Tyr Thr Gly  Leu His Cys 
    1190                 1195                 1200             


Glu Ala  Asp Ile Asn Glu Cys  Arg Pro Gly Ala Cys  His Ala Ala 
    1205                 1210                 1215             


His Thr  Arg Asp Cys Leu Gln  Asp Pro Gly Gly His  Phe Arg Cys 
    1220                 1225                 1230             


Val Cys  His Pro Gly Phe Thr  Gly Pro Arg Cys Gln  Ile Ala Leu 
    1235                 1240                 1245             


Ser Pro  Cys Glu Ser Gln Pro  Cys Gln His Gly Gly  Gln Cys Arg 
    1250                 1255                 1260             


His Ser  Leu Gly Arg Gly Gly  Gly Leu Thr Phe Thr  Cys His Cys 
    1265                 1270                 1275             


Val Pro  Pro Phe Trp Gly Leu  Arg Cys Glu Arg Val  Ala Arg Ser 
    1280                 1285                 1290             


Cys Arg  Glu Leu Gln Cys Pro  Val Gly Ile Pro Cys  Gln Gln Thr 
    1295                 1300                 1305             


Ala Arg  Gly Pro Arg Cys Ala  Cys Pro Pro Gly Leu  Ser Gly Pro 
    1310                 1315                 1320             


Ser Cys  Arg Val Ser Arg Ala  Ser Pro Ser Gly Ala  Thr Asn Ala 
    1325                 1330                 1335             


Ser Cys  Ala Ser Ala Pro Cys  Leu His Gly Gly Ser  Cys Leu Pro 
    1340                 1345                 1350             


Val Gln  Ser Val Pro Phe Phe  Arg Cys Val Cys Ala  Pro Gly Trp 
    1355                 1360                 1365             


Gly Gly  Pro Arg Cys Glu Thr  Pro Ser Ala Ala Pro  Glu Val Pro 
    1370                 1375                 1380             


Glu Glu  Pro Arg Cys Pro Arg  Ala Ala Cys Gln Ala  Lys Arg Gly 
    1385                 1390                 1395             


Asp Gln  Asn Cys Asp Arg Glu  Cys Asn Thr Pro Gly  Cys Gly Trp 
    1400                 1405                 1410             


Asp Gly  Gly Asp Cys Ser Leu  Asn Val Asp Asp Pro  Trp Arg Gln 
    1415                 1420                 1425             


Cys Glu  Ala Leu Gln Cys Trp  Arg Leu Phe Asn Asn  Ser Arg Cys 
    1430                 1435                 1440             


Asp Pro  Ala Cys Ser Ser Pro  Ala Cys Leu Tyr Asp  Asn Phe Asp 
    1445                 1450                 1455             


Cys Tyr  Ser Gly Gly Arg Asp  Arg Thr Cys Asn Pro  Val Tyr Glu 
    1460                 1465                 1470             


Lys Tyr  Cys Ala Asp His Phe  Ala Asp Gly Arg Cys  Asp Gln Gly 
    1475                 1480                 1485             


Cys Asn  Thr Glu Glu Cys Gly  Trp Asp Gly Leu Asp  Cys Ala Ser 
    1490                 1495                 1500             


Glu Val  Pro Ala Leu Leu Ala  Arg Gly Val Leu Val  Leu Thr Val 
    1505                 1510                 1515             


Leu Leu  Pro Pro Glu Glu Leu  Leu Arg Ser Ser Ala  Asp Phe Leu 
    1520                 1525                 1530             


Gln Arg  Leu Ser Ala Ile Leu  Arg Thr Ser Leu Arg  Phe Arg Leu 
    1535                 1540                 1545             


Asp Ala  Arg Gly Gln Ala Met  Val Phe Pro Tyr His  Arg Pro Ser 
    1550                 1555                 1560             


Pro Gly  Ser Glu Ser Arg Val  Arg Arg Glu Leu Gly  Pro Glu Val 
    1565                 1570                 1575             


Ile Gly  Ser Val Val Met Leu  Glu Ile Asp Asn Arg  Leu Cys Leu 
    1580                 1585                 1590             


Gln Ser  Ala Glu Asn Asp His  Cys Phe Pro Asp Ala  Gln Ser Ala 
    1595                 1600                 1605             


Ala Asp  Tyr Leu Gly Ala Leu  Ser Ala Val Glu Arg  Leu Asp Phe 
    1610                 1615                 1620             


Pro Tyr  Pro Leu Arg Asp Val  Arg Gly Glu Pro Leu  Glu Ala Pro 
    1625                 1630                 1635             


Glu Gln  Ser Val Pro Leu Leu  Pro Leu Leu Val Ala  Gly Ala Val 
    1640                 1645                 1650             


Phe Leu  Leu Ile Ile Phe Ile  Leu Gly Val Met Val  Ala Arg Arg 
    1655                 1660                 1665             


Lys Arg  Glu His Ser Thr Leu  Trp Phe Pro Glu Gly  Phe Ala Leu 
    1670                 1675                 1680             


His Lys  Asp Ile Ala Ala Gly  His Lys Gly Arg Arg  Glu Pro Val 
    1685                 1690                 1695             


Gly Gln  Asp Ala Leu Gly Met  Lys Asn Met Ala Lys  Gly Glu Ser 
    1700                 1705                 1710             


Leu Met  Gly Glu Val Val Thr  Asp Leu Asn Asp Ser  Glu Cys Pro 
    1715                 1720                 1725             


Glu Ala  Lys Arg Leu Lys Val  Glu Glu Pro Gly Met  Gly Ala Glu 
    1730                 1735                 1740             


Glu Pro  Glu Asp Cys Arg Gln  Trp Thr Gln His His  Leu Val Ala 
    1745                 1750                 1755             


Ala Asp  Ile Arg Val Ala Pro  Ala Thr Ala Leu Thr  Pro Pro Gln 
    1760                 1765                 1770             


Gly Asp  Ala Asp Ala Asp Gly  Val Asp Val Asn Val  Arg Gly Pro 
    1775                 1780                 1785             


Asp Gly  Phe Thr Pro Leu Met  Leu Ala Ser Phe Cys  Gly Gly Ala 
    1790                 1795                 1800             


Leu Glu  Pro Met Pro Ala Glu  Glu Asp Glu Ala Asp  Asp Thr Ser 
    1805                 1810                 1815             


Ala Ser  Ile Ile Ser Asp Leu  Ile Cys Gln Gly Ala  Gln Leu Gly 
    1820                 1825                 1830             


Ala Arg  Thr Asp Arg Thr Gly  Glu Thr Ala Leu His  Leu Ala Ala 
    1835                 1840                 1845             


Arg Tyr  Ala Arg Ala Asp Ala  Ala Lys Arg Leu Leu  Asp Ala Gly 
    1850                 1855                 1860             


Ala Asp  Thr Asn Ala Gln Asp  His Ser Gly Arg Thr  Pro Leu His 
    1865                 1870                 1875             


Thr Ala  Val Thr Ala Asp Ala  Gln Gly Val Phe Gln  Ile Leu Ile 
    1880                 1885                 1890             


Arg Asn  Arg Ser Thr Asp Leu  Asp Ala Arg Met Ala  Asp Gly Ser 
    1895                 1900                 1905             


Thr Ala  Leu Ile Leu Ala Ala  Arg Leu Ala Val Glu  Gly Met Val 
    1910                 1915                 1920             


Glu Glu  Leu Ile Ala Ser His  Ala Asp Val Asn Ala  Val Asp Glu 
    1925                 1930                 1935             


Leu Gly  Lys Ser Ala Leu His  Trp Ala Ala Ala Val  Asn Asn Val 
    1940                 1945                 1950             


Glu Ala  Thr Leu Ala Leu Leu  Lys Asn Gly Ala Asn  Lys Asp Met 
    1955                 1960                 1965             


Gln Asp  Ser Lys Glu Glu Thr  Pro Leu Phe Leu Ala  Ala Arg Glu 
    1970                 1975                 1980             


Gly Ser  Tyr Glu Ala Ala Lys  Leu Leu Leu Asp His  Leu Ala Asn 
    1985                 1990                 1995             


Arg Glu  Ile Thr Asp His Leu  Asp Arg Leu Pro Arg  Asp Val Ala 
    2000                 2005                 2010             


Gln Glu  Arg Leu His Gln Asp  Ile Val Arg Leu Leu  Asp Gln Pro 
    2015                 2020                 2025             


Ser Gly  Pro Arg Ser Pro Ser  Gly Pro His Gly Leu  Gly Pro Leu 
    2030                 2035                 2040             


Leu Cys  Pro Pro Gly Ala Phe  Leu Pro Gly Leu Lys  Ala Val Gln 
    2045                 2050                 2055             


Ser Gly  Thr Lys Lys Ser Arg  Arg Pro Pro Gly Lys  Thr Gly Leu 
    2060                 2065                 2070             


Gly Pro  Gln Gly Thr Arg Gly  Arg Gly Lys Lys Leu  Thr Leu Ala 
    2075                 2080                 2085             


Cys Pro  Gly Pro Leu Ala Asp  Ser Ser Val Thr Leu  Ser Pro Val 
    2090                 2095                 2100             


Asp Ser  Leu Asp Ser Pro Arg  Pro Phe Ser Gly Pro  Pro Ala Ser 
    2105                 2110                 2115             


Pro Gly  Gly Phe Pro Leu Glu  Gly Pro Tyr Ala Thr  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Ala Ser Arg Ala  Gly Pro Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Phe  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Ala  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Ala Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Thr Arg Ser Ser Pro  Thr Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Asp 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Asn Ala Thr  Ala Ser Gly 
    2270                 2275                 2280             


Ala Leu  Pro Ala Gln Pro His  Pro Ile Ser Val Pro  Ser Leu Pro 
    2285                 2290                 2295             


Gln Ser  Gln Thr Gln Leu Gly  Pro Gln Pro Glu Val  Thr Pro Lys 
    2300                 2305                 2310             


Arg Gln  Val Met Ala 
    2315             


<210>  14
<211>  2471
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Pro Ala Leu Arg Pro Ala Ala Leu Arg Ala Leu Leu Trp Leu Trp 
1               5                   10                  15      


Leu Cys Gly Ala Gly Pro Ala His Ala Leu Gln Cys Arg Gly Gly Gln 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Thr Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Arg Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Thr Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Pro Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Trp Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Gln Cys Gln Trp 
    130                 135                 140                 


Thr Asp Val Cys Leu Ser His Pro Cys Glu Asn Gly Ser Thr Cys Ser 
145                 150                 155                 160 


Ser Val Ala Asn Gln Phe Ser Cys Arg Cys Pro Ala Gly Ile Thr Gly 
                165                 170                 175     


Gln Lys Cys Asp Ala Asp Ile Asn Glu Cys Asp Ile Pro Gly Arg Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Arg Cys Gln 
        195                 200                 205             


Cys Pro Gln Arg Phe Thr Gly Gln His Cys Asp Ser Pro Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Ser Glu Cys His Cys Leu Pro Gly Phe Glu Gly Ser Asn 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Leu Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Ala Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Val Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Thr Leu Cys Asp Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Leu 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Leu His 
                645                 650                 655     


Gly Ala Cys Val Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Asp Ala Thr Cys Ile Asn Asp Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Met Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Ser Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asn Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Leu Asp Asp Val Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Met Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ala Pro Asn Phe Glu Ser Phe Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Val Asp Val Asp Glu Cys Val Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn Asn Gly Ile Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asn Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
        915                 920                 925             


Lys Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Val Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Thr Cys Pro 
                965                 970                 975     


Ala Gly Phe His Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Pro  Phe Cys Leu 
    1010                 1015                 1020             


His Asp  Ile Asn Glu Cys Ser  Ser Asn Pro Cys Leu  Asn Ser Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Thr  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Pro Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Ala Gln  Glu Lys Ala 
    1070                 1075                 1080             


Arg Pro  Arg Cys Leu Cys Pro  Pro Gly Trp Asp Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Leu Asn Val Ser Cys  Lys Ala Ala Ala Leu  Gln Lys Gly 
    1100                 1105                 1110             


Val Pro  Val Glu His Leu Cys  Gln His Ser Gly Ile  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His His Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Gly Ala Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Val Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Lys  Asn Asn Tyr Gln Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Leu  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Lys Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Val  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Arg 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro His  Cys Phe Cys 
    1355                 1360                 1365             


Pro Asn  His Lys Asp Cys Glu  Ser Gly Cys Ala Ser  Asn Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Thr Cys Tyr  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Arg Cys Ser Pro Pro  Phe Trp Gly Ser His  Cys Glu Ser 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Thr Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Ile Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asp Pro Trp Ala Asn  Cys Thr Ser Ser Leu  Arg Cys Trp 
    1460                 1465                 1470             


Glu Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Ala Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Arg Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Lys  Gly Cys Asn Asn Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Ile Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Leu Pro Pro  Glu Gln Leu Leu Gln  Asp Ser Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Gln Asp Ser Gln Gly  Ala Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Lys Val  Ala Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Asp Glu Gln Glu  Gln Glu Ile Ile Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp Gln 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Glu Asp Pro Arg Asn  Thr Pro Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Leu Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Phe Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ser Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Ser Thr Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Gly Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Ala Lys  Ala Glu Asp 
    1760                 1765                 1770             


Asp Glu  Ala Leu Leu Ser Glu  Asp Asp Pro Val Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Leu Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ala 
    2090                 2095                 2100             


Arg Arg  Pro Asn Thr Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Val Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Cys Leu  Asn Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Ala Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Thr Pro Leu Leu Ala  Ala Ala Pro Ala Ala  Pro Val His 
    2180                 2185                 2190             


Ala Gln  His Ala Leu Ser Phe  Ser Asn Leu His Glu  Met Gln Pro 
    2195                 2200                 2205             


Leu Arg  Pro Gly Ala Ser Thr  Val Leu Pro Ser Val  Ser Gln Leu 
    2210                 2215                 2220             


Leu Ser  His His His Ile Val  Pro Pro Gly Ser Gly  Ser Ala Gly 
    2225                 2230                 2235             


Ser Leu  Gly Arg Leu His Ser  Val Pro Val Pro Ser  Asp Trp Met 
    2240                 2245                 2250             


Asn Arg  Val Glu Met Ser Glu  Thr Gln Tyr Ser Glu  Met Phe Gly 
    2255                 2260                 2265             


Met Val  Leu Ala Pro Ala Glu  Gly Thr His Pro Gly  Met Ala Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Ala Pro Glu  Gly Lys Pro Ile Pro  Thr Gln Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Leu  Ala Gln Ala Ala Gly  Ala Pro Gln Thr Gln  Ser Gly Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Ser Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Pro  Thr Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Glu Gly Gln Val  Ala Gln Thr Ile Val  Pro Thr Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Asn 
    2390                 2395                 2400             


His Gly  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Gly 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Ser  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  15
<211>  2319
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Leu Met Ala 
1               5                   10                  15      


Leu Pro Pro Pro Pro Pro Pro Met Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Gly Leu Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser 
        35                  40                  45              


Pro Cys Ala Asn Gly Gly Arg Cys Thr His Gln Gln Pro Ser Arg Glu 
    50                  55                  60                  


Ala Ala Cys Leu Cys Leu Pro Gly Trp Val Gly Glu Arg Cys Gln Leu 
65                  70                  75                  80  


Glu Asp Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln 
                85                  90                  95      


Ser Ser Val Val Ala Gly Val Ala Arg Phe Ser Cys Arg Cys Leu Arg 
            100                 105                 110         


Gly Phe Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Phe Ser Ser 
        115                 120                 125             


Pro Cys Ala His Gly Ala Pro Cys Ser Val Gly Ser Asp Gly Arg Tyr 
    130                 135                 140                 


Ala Cys Ala Cys Pro Pro Gly Tyr Gln Gly Arg Asn Cys Arg Ser Asp 
145                 150                 155                 160 


Ile Asp Glu Cys Arg Ala Gly Ala Ser Cys Arg His Gly Gly Thr Cys 
                165                 170                 175     


Ile Asn Thr Pro Gly Ser Phe His Cys Leu Cys Pro Leu Gly Tyr Thr 
            180                 185                 190         


Gly Leu Leu Cys Glu Asn Pro Ile Val Pro Cys Ala Pro Ser Pro Cys 
        195                 200                 205             


Arg Asn Gly Gly Thr Cys Arg Gln Ser Ser Asp Val Thr Tyr Asp Cys 
    210                 215                 220                 


Ala Cys Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp 
225                 230                 235                 240 


Asp Cys Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly 
                245                 250                 255     


Val Asn Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe 
            260                 265                 270         


Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His 
        275                 280                 285             


Asn Gly Gly Thr Cys Phe Asn Leu Leu Gly Gly His Ser Cys Val Cys 
    290                 295                 300                 


Val Asn Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys 
305                 310                 315                 320 


Ala Thr Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala 
                325                 330                 335     


Ser Phe Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His 
            340                 345                 350         


Leu Asp Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys 
        355                 360                 365             


Asp Thr Asn Pro Val Ser Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly 
    370                 375                 380                 


Phe Thr Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly 
385                 390                 395                 400 


Ala Asn Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser 
                405                 410                 415     


Phe Leu Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr 
            420                 425                 430         


Asp Val Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys 
        435                 440                 445             


Leu Asp Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr 
    450                 455                 460                 


Gly Thr Phe Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys 
465                 470                 475                 480 


Val Asn Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr 
                485                 490                 495     


Cys Pro Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu 
            500                 505                 510         


Cys Ala Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro 
        515                 520                 525             


Asp Gly Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys 
    530                 535                 540                 


Glu Arg Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg 
545                 550                 555                 560 


Cys Val Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr 
                565                 570                 575     


Thr Gly Ile Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro 
            580                 585                 590         


Cys Arg Tyr Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys 
        595                 600                 605             


Arg Cys Pro Pro Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp 
    610                 615                 620                 


Asp Cys Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile 
625                 630                 635                 640 


Asn Arg Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys 
                645                 650                 655     


Asn Val Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly 
            660                 665                 670         


Ser Cys Val Asp Gly Glu Asn Gly Phe His Cys Leu Cys Pro Pro Gly 
        675                 680                 685             


Ser Leu Pro Pro Leu Cys Leu Pro Ala Asn His Pro Cys Ala His Lys 
    690                 695                 700                 


Pro Cys Ser His Gly Val Cys His Asp Ala Pro Gly Gly Phe Gln Cys 
705                 710                 715                 720 


Val Cys Asp Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala 
                725                 730                 735     


Pro Asp Ala Cys Glu Ser Gln Pro Cys Gln Ala Gly Gly Thr Cys Thr 
            740                 745                 750         


Ser Asp Gly Ile Gly Phe His Cys Thr Cys Ala Pro Gly Phe Gln Gly 
        755                 760                 765             


His Gln Cys Glu Val Leu Ser Pro Cys Thr Pro Ser Leu Cys Glu His 
    770                 775                 780                 


Gly Gly His Cys Glu Ser Asp Pro Asp Gln Leu Thr Val Cys Ser Cys 
785                 790                 795                 800 


Pro Pro Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys 
                805                 810                 815     


Ala Gly Ala Ser Pro Cys Gly Pro His Gly Thr Cys Thr Asn Leu Pro 
            820                 825                 830         


Gly Ser Phe Arg Cys Ile Cys His Gly Gly Tyr Thr Gly Pro Phe Cys 
        835                 840                 845             


Asp Gln Asp Ile Asp Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly 
    850                 855                 860                 


Ser Cys Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Ser Gly 
865                 870                 875                 880 


Phe Ala Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Ser 
                885                 890                 895     


Pro Cys Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys 
            900                 905                 910         


Thr Cys Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Thr Asp Leu Leu 
        915                 920                 925             


Asp Cys Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly 
    930                 935                 940                 


Val Asn Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Thr His 
945                 950                 955                 960 


Cys Gln Tyr Lys Val Asp Pro Cys Phe Ser Arg Pro Cys Leu His Gly 
                965                 970                 975     


Gly Ile Cys Asn Pro Thr His Ser Gly Phe Glu Cys Thr Cys Arg Glu 
            980                 985                 990         


Gly Phe Thr Gly Asn Gln Cys Gln  Asn Pro Val Asp Trp  Cys Ser Gln 
        995                 1000                 1005             


Ala Pro  Cys Gln Asn Gly Gly  Arg Cys Val Gln Thr  Gly Ala Tyr 
    1010                 1015                 1020             


Cys Ile  Cys Pro Pro Glu Trp  Ser Gly Pro Leu Cys  Asp Ile Pro 
    1025                 1030                 1035             


Ser Leu  Pro Cys Thr Glu Ala  Ala Ala His Met Gly  Val Arg Leu 
    1040                 1045                 1050             


Glu Gln  Leu Cys Gln Ala Gly  Gly Gln Cys Ile Asp  Lys Asp His 
    1055                 1060                 1065             


Ser His  Tyr Cys Val Cys Pro  Glu Gly Arg Met Gly  Ser His Cys 
    1070                 1075                 1080             


Glu Gln  Glu Val Asp Pro Cys  Thr Ala Gln Pro Cys  Gln His Gly 
    1085                 1090                 1095             


Gly Thr  Cys Arg Gly Tyr Met  Gly Gly Tyr Val Cys  Glu Cys Pro 
    1100                 1105                 1110             


Thr Gly  Tyr Ser Gly Asp Ser  Cys Glu Asp Asp Val  Asp Glu Cys 
    1115                 1120                 1125             


Ala Ser  Gln Pro Cys Gln Asn  Gly Gly Ser Cys Ile  Asp Leu Val 
    1130                 1135                 1140             


Ala His  Tyr Leu Cys Ser Cys  Pro Pro Gly Thr Leu  Gly Val Leu 
    1145                 1150                 1155             


Cys Glu  Ile Asn Glu Asp Asp  Cys Gly Pro Gly Pro  Ser Leu Asp 
    1160                 1165                 1170             


Ser Gly  Leu Arg Cys Leu His  Asn Gly Thr Cys Val  Asp Leu Val 
    1175                 1180                 1185             


Gly Gly  Phe Arg Cys Asn Cys  Pro Pro Gly Tyr Thr  Gly Leu His 
    1190                 1195                 1200             


Cys Glu  Ala Asp Ile Asn Glu  Cys Arg Pro Gly Thr  Cys His Ala 
    1205                 1210                 1215             


Ala His  Thr Arg Asp Cys Leu  Gln Asp Pro Gly Gly  His Phe Arg 
    1220                 1225                 1230             


Cys Ile  Cys Leu Pro Gly Phe  Thr Gly Pro Arg Cys  Gln Thr Ala 
    1235                 1240                 1245             


Leu Phe  Pro Cys Glu Ser Gln  Pro Cys Gln His Gly  Gly Gln Cys 
    1250                 1255                 1260             


Arg Pro  Ser Leu Gly Arg Gly  Gly Gly Leu Thr Phe  Thr Cys His 
    1265                 1270                 1275             


Cys Val  Gln Pro Phe Trp Gly  Leu Arg Cys Glu Arg  Val Ala Arg 
    1280                 1285                 1290             


Ser Cys  Arg Glu Leu Gln Cys  Pro Val Gly Ile Pro  Cys Gln Gln 
    1295                 1300                 1305             


Thr Ala  Arg Gly Pro Arg Cys  Ala Cys Pro Pro Gly  Leu Ser Gly 
    1310                 1315                 1320             


Pro Ser  Cys Arg Val Ser Arg  Ala Ser Pro Ser Gly  Ala Thr Asn 
    1325                 1330                 1335             


Thr Ser  Cys Ala Ala Thr Pro  Cys Leu His Gly Gly  Ser Cys Leu 
    1340                 1345                 1350             


Pro Val  Gln Ser Val Pro Phe  Phe Arg Cys Val Cys  Ala Pro Gly 
    1355                 1360                 1365             


Trp Gly  Gly Pro Arg Cys Glu  Thr Pro Ser Ala Ala  Pro Glu Val 
    1370                 1375                 1380             


Pro Glu  Glu Pro Arg Cys Pro  Arg Ala Ala Cys Gln  Ala Lys Arg 
    1385                 1390                 1395             


Gly Asp  Gln Asn Cys Asp Arg  Glu Cys Asn Ser Pro  Gly Cys Gly 
    1400                 1405                 1410             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Val Asp Asp  Pro Trp Arg 
    1415                 1420                 1425             


Gln Cys  Glu Ala Leu Gln Cys  Trp Arg Leu Phe Asn  Asn Ser Arg 
    1430                 1435                 1440             


Cys Asp  Pro Ala Cys Ser Ser  Pro Ala Cys Leu Tyr  Asp Asn Phe 
    1445                 1450                 1455             


Asp Cys  Tyr Ser Gly Gly Arg  Asp Arg Thr Cys Asn  Pro Val Tyr 
    1460                 1465                 1470             


Lys Lys  Tyr Cys Ala Asp His  Phe Ala Asp Gly Arg  Cys Asp Gln 
    1475                 1480                 1485             


Gly Cys  Asn Thr Glu Glu Cys  Gly Trp Asp Gly Leu  Asp Cys Ala 
    1490                 1495                 1500             


Ser Glu  Val Pro Ala Leu Leu  Ala Arg Gly Val Leu  Val Leu Thr 
    1505                 1510                 1515             


Val Leu  Leu Pro Pro Glu Glu  Leu Leu Arg Ser Ser  Ala Asp Phe 
    1520                 1525                 1530             


Leu Gln  Arg Leu Ser Ala Ile  Leu Arg Thr Ser Leu  Arg Phe Arg 
    1535                 1540                 1545             


Leu Asp  Ala Arg Gly Gln Ala  Met Val Phe Pro Tyr  His Arg Pro 
    1550                 1555                 1560             


Ser Pro  Gly Ser Glu Ser Arg  Val Arg Arg Glu Leu  Gly Pro Glu 
    1565                 1570                 1575             


Val Ile  Gly Ser Val Val Met  Leu Glu Ile Asp Asn  Arg Leu Cys 
    1580                 1585                 1590             


Leu Lys  Ser Ala Glu Asn Asp  His Cys Phe Pro Asp  Ala Gln Ser 
    1595                 1600                 1605             


Ala Ala  Asp Tyr Leu Gly Ala  Leu Ser Ala Val Glu  Arg Leu Asp 
    1610                 1615                 1620             


Phe Pro  Tyr Pro Leu Arg Asp  Val Arg Gly Glu Pro  Leu Glu Pro 
    1625                 1630                 1635             


Pro Glu  Gln Ser Val Pro Leu  Leu Pro Leu Leu Val  Ala Gly Ala 
    1640                 1645                 1650             


Val Phe  Leu Leu Val Ile Phe  Val Leu Gly Val Met  Val Ala Arg 
    1655                 1660                 1665             


Arg Lys  Arg Glu His Ser Thr  Leu Trp Phe Pro Glu  Gly Phe Ala 
    1670                 1675                 1680             


Leu His  Lys Asp Ile Ala Ala  Gly His Lys Gly Arg  Arg Glu Pro 
    1685                 1690                 1695             


Val Gly  Gln Asp Ala Leu Gly  Met Lys Asn Met Thr  Lys Gly Glu 
    1700                 1705                 1710             


Ser Leu  Met Gly Glu Val Ala  Thr Asp Trp Asn Asp  Ser Glu Cys 
    1715                 1720                 1725             


Pro Glu  Ala Lys Arg Leu Lys  Val Glu Glu Pro Gly  Met Gly Ala 
    1730                 1735                 1740             


Glu Glu  Pro Val Asp Cys Arg  Gln Trp Thr Gln His  His Leu Val 
    1745                 1750                 1755             


Ala Ala  Asp Ile Arg Val Ala  Pro Ala Met Ala Leu  Thr Pro Pro 
    1760                 1765                 1770             


Gln Gly  Asp Ala Asp Ala Asp  Gly Met Asp Val Asn  Val Arg Gly 
    1775                 1780                 1785             


Pro Asp  Gly Phe Thr Pro Leu  Met Leu Ala Ser Phe  Cys Gly Gly 
    1790                 1795                 1800             


Ala Leu  Glu Pro Met Pro Ala  Glu Glu Asp Glu Ala  Asp Asp Thr 
    1805                 1810                 1815             


Ser Ala  Ser Ile Ile Ser Asp  Leu Ile Cys Gln Gly  Ala Gln Leu 
    1820                 1825                 1830             


Gly Ala  Arg Thr Asp Arg Thr  Gly Glu Thr Ala Leu  His Leu Ala 
    1835                 1840                 1845             


Ala Arg  Tyr Ala Arg Ala Asp  Ala Ala Lys Arg Leu  Leu Asp Ala 
    1850                 1855                 1860             


Gly Ala  Asp Thr Asn Ala Gln  Asp His Ser Gly Arg  Thr Pro Leu 
    1865                 1870                 1875             


His Thr  Ala Val Thr Ala Asp  Ala Gln Gly Val Phe  Gln Ile Leu 
    1880                 1885                 1890             


Ile Arg  Asn Arg Ser Thr Asp  Leu Asp Ala Arg Met  Ala Asp Gly 
    1895                 1900                 1905             


Ser Thr  Ala Leu Ile Leu Ala  Ala Arg Leu Ala Val  Glu Gly Met 
    1910                 1915                 1920             


Val Glu  Glu Leu Ile Ala Ser  His Ala Asp Val Asn  Ala Val Asp 
    1925                 1930                 1935             


Glu Leu  Gly Lys Ser Ala Leu  His Trp Ala Ala Ala  Val Asn Asn 
    1940                 1945                 1950             


Val Glu  Ala Thr Leu Ala Leu  Leu Lys Asn Gly Ala  Asn Lys Asp 
    1955                 1960                 1965             


Met Gln  Asp Ser Lys Glu Glu  Thr Pro Leu Phe Leu  Ala Ala Arg 
    1970                 1975                 1980             


Glu Gly  Ser Tyr Glu Ala Ala  Lys Leu Leu Leu Asp  His Phe Ala 
    1985                 1990                 1995             


Asn Arg  Glu Ile Thr Asp His  Leu Asp Arg Leu Pro  Arg Asp Val 
    2000                 2005                 2010             


Ala Gln  Glu Arg Leu His Gln  Asp Ile Val Arg Leu  Leu Asp Gln 
    2015                 2020                 2025             


Pro Ser  Gly Pro Arg Ser Pro  Ser Gly Pro His Gly  Leu Gly Pro 
    2030                 2035                 2040             


Leu Leu  Cys Pro Pro Gly Ala  Phe Leu Pro Gly Leu  Lys Ala Val 
    2045                 2050                 2055             


Gln Ser  Gly Thr Lys Lys Ser  Arg Arg Pro Pro Gly  Lys Thr Gly 
    2060                 2065                 2070             


Leu Gly  Pro Gln Gly Thr Arg  Gly Arg Gly Lys Lys  Leu Thr Leu 
    2075                 2080                 2085             


Ala Cys  Pro Gly Pro Leu Ala  Asp Ser Ser Val Thr  Leu Ser Pro 
    2090                 2095                 2100             


Val Asp  Ser Leu Asp Ser Pro  Arg Pro Phe Gly Gly  Pro Pro Ala 
    2105                 2110                 2115             


Ser Pro  Gly Gly Phe Pro Leu  Glu Gly Pro Tyr Ala  Thr Thr Ala 
    2120                 2125                 2130             


Thr Thr  Val Ser Leu Ala Gln  Leu Gly Ala Ser Arg  Ala Gly Pro 
    2135                 2140                 2145             


Leu Gly  Arg Gln Pro Pro Gly  Gly Cys Val Leu Ser  Leu Gly Leu 
    2150                 2155                 2160             


Leu Asn  Pro Val Ala Val Pro  Leu Asp Trp Ala Arg  Leu Pro Pro 
    2165                 2170                 2175             


Pro Ala  Pro Pro Gly Pro Ser  Phe Leu Leu Pro Leu  Ala Pro Gly 
    2180                 2185                 2190             


Ser Gln  Leu Leu Asn Pro Ala  Thr Pro Val Ser Pro  His Glu Arg 
    2195                 2200                 2205             


Pro Pro  Pro Tyr Leu Ala Ala  Pro Gly His Gly Glu  Glu Tyr Pro 
    2210                 2215                 2220             


Ala Ala  Gly Thr His Ser Ser  Pro Thr Lys Ala Arg  Phe Leu Arg 
    2225                 2230                 2235             


Val Pro  Ser Glu His Pro Tyr  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2240                 2245                 2250             


Glu His  Trp Ala Ser Pro Ser  Pro Pro Ser Leu Ser  Asp Trp Ser 
    2255                 2260                 2265             


Asp Ser  Thr Pro Ser Pro Ala  Thr Ala Thr Ser Ala  Thr Ala Ala 
    2270                 2275                 2280             


Gly Ala  Leu Pro Ala Gln Pro  His Pro Ile Ser Val  Pro Ser Leu 
    2285                 2290                 2295             


Pro Gln  Ser Gln Thr Gln Leu  Gly Pro Gln Pro Glu  Val Thr Pro 
    2300                 2305                 2310             


Lys Arg  Gln Val Met Ala 
    2315                 


<210>  16
<211>  333
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  16

Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro 
1               5                   10                  15      


Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala 
            20                  25                  30          


Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp 
        35                  40                  45              


Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys 
    50                  55                  60                  


Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp 
65                  70                  75                  80  


Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln 
                85                  90                  95      


Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp 
            100                 105                 110         


His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys 
        115                 120                 125             


Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala 
    130                 135                 140                 


Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg 
145                 150                 155                 160 


Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr 
                165                 170                 175     


Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro 
            180                 185                 190         


Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser 
        195                 200                 205             


Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly 
    210                 215                 220                 


Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val 
225                 230                 235                 240 


Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys 
                245                 250                 255     


Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser 
            260                 265                 270         


Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu 
        275                 280                 285             


Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala 
    290                 295                 300                 


Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu 
305                 310                 315                 320 


Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu 
                325                 330             


<210>  17
<211>  370
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  17

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly 
        35                  40                  45              


Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu 
    50                  55                  60                  


Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn 
65                  70                  75                  80  


His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp 
                85                  90                  95      


Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser 
            100                 105                 110         


Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 
        115                 120                 125             


Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp 
    130                 135                 140                 


Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys 
145                 150                 155                 160 


Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val 
                165                 170                 175     


Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro 
            180                 185                 190         


Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser 
        195                 200                 205             


His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln 
    210                 215                 220                 


Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His 
225                 230                 235                 240 


Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro 
                245                 250                 255     


Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile 
            260                 265                 270         


Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln 
        275                 280                 285             


Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu 
    290                 295                 300                 


Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu 
305                 310                 315                 320 


Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His 
                325                 330                 335     


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
            340                 345                 350         


Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln 
        355                 360                 365             


Lys Leu 
    370 


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  18

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  19

Lys Leu Val Val Val Gly Ala Gly Gly Val 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  20

Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  21

Lys Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  22

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  23

Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  24

Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  25

Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  26

Lys Ile Thr Asp Phe Gly Leu Ala Lys 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  27

Lys Ile Thr Asp Phe Gly Arg Ala Lys 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  28

Val Leu Gln Glu Leu Asn Val Thr Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  29

Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  30

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  31

Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  32

Ser Thr Thr Pro Pro Pro Gly Thr Arg Val 
1               5                   10  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  33

Arg Met Pro Glu Ala Ala Pro Pro Val 
1               5                   


<210>  34
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  34

Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val 
1               5                   10      


<210>  35
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  35

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  36

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  37

Ile Met Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  38

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  39

Tyr Leu Glu Pro Gly Pro Val Thr Val 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  40

Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  41

Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  42

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  43

Ala Ile Ile Arg Ile Leu Gln Gln Leu 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  44

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  45

Val Leu Arg Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  46

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  47
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  47

Leu Leu Asp Phe Val Arg Phe Met Gly Val 
1               5                   10  


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  48

Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  49

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  50

Gly Val Leu Pro Ala Leu Pro Gln Val 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  51

Thr Met Thr Arg Val Leu Gln Gly Val 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  52

Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  53

Ile Leu Ala Lys Phe Leu His Trp Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  54

Arg Leu Val Asp Asp Phe Leu Leu Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  55

Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  56

Phe Leu Arg Asn Phe Ser Leu Met Leu 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  57

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  58

Tyr Leu Leu Pro Ala Ile Val His Ile 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  59

Phe Leu Ser Glu Leu Thr Gln Gln Leu 
1               5                   


<210>  60
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  60

Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210>  61
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  61

Ser Tyr Ala Met Ser 
1               5   


<210>  62
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  62

Gln Ile Asp Pro Trp Gly Gln Glu Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  63

Leu Thr Gly Arg Phe Asp Tyr 
1               5           


<210>  64
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  64

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  65

Ser Ala Ser Gln Leu Gln Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  66

Gln Gln Gly Pro Gly Thr Pro Asn Thr 
1               5                   


<210>  67
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gln Ile Asp Pro Trp Gly Gln Glu Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Thr Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ser Ala Ser Gln Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Pro 
    210                 215                 220                 


Gly Thr Pro Asn Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235                 240 


Ala 
    


<210>  68
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Asn Ile Asn Gly Ser Tyr Ile His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Asp Pro 
                165                 170                 175     


Glu Thr Gly Tyr Ser Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Asp Ser Ala 
    210                 215                 220                 


Ser Asp Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  69
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe His Ile Asn Gly Ser Tyr Ile His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val Ala Tyr Ile Asp Pro 
                165                 170                 175     


Glu Thr Gly Tyr Ser Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala 
            180                 185                 190         


Ile Ser Ala Asp Met Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Asp Ser Ala 
    210                 215                 220                 


Ser Asp Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  70
<211>  243
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Asn Ile Thr Ser Ser Tyr Ile His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Pro 
                165                 170                 175     


Glu Asp Gly Tyr Ala Arg His Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Asp Asp Thr 
    210                 215                 220                 


Tyr Tyr Tyr Ser Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  71
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  71

His Leu Ser Pro Ile Asp Cys Glu Val 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  72

Leu Thr Ser Met Trp Ser Pro Ala Val 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  73

His Leu Asp His Pro His Pro Ala Val 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  74

Ser Leu Ser Val Met Ser Ser Asn Val 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  75

Met Met Ala Trp Ser Asp Asn Lys Ile 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  76

Thr Gln Ile Gly Ile Glu Trp Asn Leu 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  77

Cys Leu Phe Glu Met Gln Asp Pro Ala 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  78

Tyr Leu Ser His Pro Ser Cys Asn Val 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  79

Gly Ile Glu Trp Asn Leu Ser Pro Val 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  80

Gly Leu Gly Cys Ser Pro Ala Ser Ile 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  81

Arg Gln Ala Phe Glu Phe Pro Gln Ile 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  82

Gly Met Trp Thr Asp Thr Phe Glu Phe 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  83

Tyr Leu Asn Trp Gln Asp Thr Ala Val 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  84

Val Leu Trp Gly Pro Ile Thr Gln Ile 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  85

Thr Leu Asp His Thr Gly Val Val Val 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  86

Thr Met Gly Val Trp Leu His Ile Ala 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  87

Lys Val Trp Val Gln Gly His Tyr Leu 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  88

Lys Ile Asn Cys Asn Asn Phe Arg Leu 
1               5                   


<210>  89
<211>  56
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  89

Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro 
1               5                   10                  15      


Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val 
            20                  25                  30          


Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg 
        35                  40                  45              


Arg Gln Leu Cys Ile Gln Lys Leu 
    50                  55      


<210>  90
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  90

Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
1               5                   10                  15      


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
            20                  25                  30          


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40                  45              


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
    50                  55                  60                  


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
65                  70                  75                  80  


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
                85                  90                  95      


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
            100                 105                 110         


Cys Glu Trp Asp Gly Leu Asp Cys 
        115                 120 


<210>  91
<211>  152
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  91

Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
1               5                   10                  15      


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
            20                  25                  30          


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
        35                  40                  45              


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
    50                  55                  60                  


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
                85                  90                  95      


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
            100                 105                 110         


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
        115                 120                 125             


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
    130                 135                 140                 


Glu Pro Val Glu Pro Pro Leu Pro 
145                 150         


<210>  92
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  92

His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
1               5                   10                  15      


Gly Cys Gly Val Leu Leu Ser 
            20              


<210>  93
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  93

Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
1               5                   10                  15      


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
            20                  25                  30          


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40                  45              


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
    50                  55                  60                  


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
65                  70                  75                  80  


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
                85                  90                  95      


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
            100                 105                 110         


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
        115                 120                 125             


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
    130                 135                 140                 


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
145                 150                 155                 160 


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
                165                 170                 175     


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
            180                 185                 190         


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
        195                 200                 205             


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
    210                 215                 220                 


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
225                 230                 235                 240 


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
                245                 250                 255     


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
            260                 265                 270         


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
    290                 295                 300                 


Leu Ser 
305     


<210>  94
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  94

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly 
        35                  40                  45              


Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu 
    50                  55                  60                  


Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn 
65                  70                  75                  80  


His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp 
                85                  90                  95      


Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser 
            100                 105                 110         


Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 
        115                 120                 125             


Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp 
    130                 135                 140                 


Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys 
145                 150                 155                 160 


Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val 
                165                 170                 175     


Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro 
            180                 185                 190         


Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser 
        195                 200                 205             


His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln 
    210                 215                 220                 


Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His 
225                 230                 235                 240 


Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro 
                245                 250                 255     


Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile 
            260                 265                 270         


Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln 
        275                 280                 285             


Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu 
    290                 295                 300                 


Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu 
305                 310                 315                 320 


Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His 
                325                 330                 335     


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
            340                 345                 350         


Cys Gly Val Leu Leu Ser 
        355             


<210>  95
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  95

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His 
        35          


<210>  96
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  96

Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His Gly Ala Ser Cys 
1               5                   10                  15      


Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln Ala Gly Tyr Ser 
            20                  25                  30          


Gly Arg Asn Cys Glu 
        35          


<210>  97
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  97

Asp Ile Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys 
1               5                   10                  15      


Thr Asp Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg 
            20                  25                  30          


Gly Thr Phe Cys Glu 
        35          


<210>  98
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  98

Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
1               5                   10                  15      


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
            20                  25                  30          


Gly Ile His Cys Glu 
        35          


<210>  99
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  99

Thr Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn 
1               5                   10                  15      


Ser Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln 
            20                  25                  30          


<210>  100
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  100

Asp Val Asn Glu Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys 
1               5                   10                  15      


Gln Asp Gly Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr 
            20                  25                  30          


Gly Pro Asn Cys Gln 
        35          


<210>  101
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  101

Asp Ser Ser Pro Cys Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr 
1               5                   10                  15      


Gln Tyr Arg Cys Glu Cys Pro Ser Gly Trp Thr 
            20                  25          


<210>  102
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  102

Leu Val Asp Glu Cys Ser Pro Ser Pro Cys Gln Asn Gly Ala Thr Cys 
1               5                   10                  15      


Thr Asp Tyr Leu Gly Gly Tyr Ser Cys Lys Cys Val Ala Gly Tyr His 
            20                  25                  30          


Gly Val Asn Cys 
        35      


<210>  103
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  103

Ile Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu 
1               5                   10                  15      


Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly 
            20                  25                  30          


Val His Cys Glu 
        35      


<210>  104
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  104

Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val Gly Gly Tyr Ser Cys 
1               5                   10                  15      


Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys Glu 
            20                  25              


<210>  105
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  105

Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Ala Arg Gly Thr Gln 
1               5                   10                  15      


Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg Ala Gly 
            20                  25                  30          


His Thr Gly Arg Arg Cys Glu 
        35                  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  106

Gly Arg Arg Arg Arg Glu Leu Asp Pro Met 
1               5                   10  


<210>  107
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  107

Arg Gln Arg Arg Glu Leu Asp Pro Met 
1               5                   


<210>  108
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  108

Lys Ile Glu Ala Val Lys Ser Glu 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  109

Lys Ile Glu Ala Val Gln Ser Glu 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  110

Val Gly Cys Gly Val Leu Leu Ser 
1               5               


<210>  111
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  111

Gly Cys Gly Val Leu Leu Ser 
1               5           


<210>  112
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  112

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  113
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  113

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210>  114
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  114

Pro Lys Lys Lys Arg Lys Val Asp Ala Leu Asp Asp Phe Asp Leu Asp 
1               5                   10                  15      


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
            20                  25                  30          


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
        35                  40                  45              


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Gly Ser Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
65                  70                  75                  80  


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
                85                  90                  95      


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
            100                 105                 110         


Gly Gly Lys 
        115 


<210>  115
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  115

Gly Gly Gly Gly Ser 
1               5   


<210>  116
<211>  282
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  116

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Leu Asp Gly Thr Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala 
    130                 135                 140                 


Lys Lys Asp Gly Lys Ser Met Ser Ile Gly Leu Leu Cys Cys Ala Ala 
145                 150                 155                 160 


Leu Ser Leu Leu Trp Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr 
                165                 170                 175     


Pro Lys Phe Gln Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys 
            180                 185                 190         


Ala Gln Asp Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro 
        195                 200                 205             


Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Asp Arg Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Ile 
225                 230                 235                 240 


Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser 
                245                 250                 255     


Val Tyr Phe Cys Ala Ser Ser Tyr Val Gly Asp Thr Gly Glu Leu Phe 
            260                 265                 270         


Phe Gly Glu Gly Ser Arg Leu Thr Val Leu 
        275                 280         


<210>  117
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  117

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  118
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  118

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  119
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  119

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  120
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  120

His His His His His 
1               5   


<210>  121
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  121

His His His His His His 
1               5       


<210>  122
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  122

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  123
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  123

Arg Tyr Ile Arg Ser 
1               5   


<210>  124
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  124

Phe His His Thr 
1               


<210>  125
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  125

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  126
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  126

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  127
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  127

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  128
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  128

Met Val Pro Lys Lys Lys Arg Lys 
1               5               


<210>  129
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  129

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala 
    


<210>  130
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  The residue at this position may be any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  The residue at this position may be an Arg or Lys.

<400>  130

Arg Xaa Xaa Arg 
1               


<210>  131
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic amino acid sequence

<400>  131

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  132
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic amino acid sequence

<400>  132

Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
1               5                   10                  15      


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
    50                  55                  60                  


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
65                  70                  75                  80  


Thr Asn Ala Cys Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
                85                  90                  95      


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
            100                 105                 110         


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
        115                 120                 125             


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135             


<210>  133
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic amino acid sequence

<400>  133

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  134
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic amino acid sequence

<400>  134

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Cys Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


