                         SEQUENCE LISTING

<110>  NAL PHARMACEUTICAL GROUP LIMITED
       MO, Y.Joseph
 
<120>  COMPOSITIONS CONTAINING FUSION PROTEIN OF ALBUMIN AND 
       ANALOGS THEREOF, METHODS FOR MAKING AND USING THE SAME

<130>  4019-1015-W-CIP-W

<150>  US 15/249,346
<151>  2016-08-26

<150>  PCT/US2016/019950
<151>  2016-02-26

<150>  TW 105106088 
<151>  2016-02-26

<150>  US 62/121,487
<151>  2015-02-26

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  657
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  1

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
        35                  40                  45              


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
    50                  55                  60                  


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
65                  70                  75                  80  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
                85                  90                  95      


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
            100                 105                 110         


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
        115                 120                 125             


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
    130                 135                 140                 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
145                 150                 155                 160 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
                165                 170                 175     


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
            180                 185                 190         


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
        195                 200                 205             


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
    210                 215                 220                 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
225                 230                 235                 240 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
                245                 250                 255     


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
            260                 265                 270         


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
        275                 280                 285             


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
    290                 295                 300                 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
305                 310                 315                 320 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
                325                 330                 335     


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
            340                 345                 350         


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
        355                 360                 365             


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
    370                 375                 380                 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
385                 390                 395                 400 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
                405                 410                 415     


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
            420                 425                 430         


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
        435                 440                 445             


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
    450                 455                 460                 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
465                 470                 475                 480 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
                485                 490                 495     


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
            500                 505                 510         


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
        515                 520                 525             


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
    530                 535                 540                 


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
545                 550                 555                 560 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
                565                 570                 575     


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
            580                 585                 590         


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
        595                 600                 605             


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Glu Ala 
    610                 615                 620                 


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
625                 630                 635                 640 


Ala Lys Ala Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser 
                645                 650                 655     


Cys 
    


<210>  2
<211>  621
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  2

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Glu Ala Ala Ala Lys Glu 
            580                 585                 590         


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala 
        595                 600                 605             


Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
    610                 615                 620     


<210>  3
<211>  1203
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  3

His His His His His His Gly Gly Ser Asp Ala His Lys Ser Glu Val 
1               5                   10                  15      


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
            20                  25                  30          


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
        35                  40                  45              


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
    50                  55                  60                  


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
65                  70                  75                  80  


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
                85                  90                  95      


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
            100                 105                 110         


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
        115                 120                 125             


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
    130                 135                 140                 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
145                 150                 155                 160 


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
                165                 170                 175     


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
            180                 185                 190         


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
        195                 200                 205             


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
    210                 215                 220                 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
225                 230                 235                 240 


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
                245                 250                 255     


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
            260                 265                 270         


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
        275                 280                 285             


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
    290                 295                 300                 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
305                 310                 315                 320 


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
                325                 330                 335     


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
            340                 345                 350         


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
        355                 360                 365             


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
    370                 375                 380                 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
385                 390                 395                 400 


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
                405                 410                 415     


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
            420                 425                 430         


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
        435                 440                 445             


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
    450                 455                 460                 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
465                 470                 475                 480 


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
                485                 490                 495     


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
            500                 505                 510         


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
        515                 520                 525             


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
    530                 535                 540                 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
545                 550                 555                 560 


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
                565                 570                 575     


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
            580                 585                 590         


Gly Leu Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys 
        595                 600                 605             


Thr Phe Thr Ser Cys Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu 
    610                 615                 620                 


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
625                 630                 635                 640 


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
                645                 650                 655     


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
            660                 665                 670         


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
        675                 680                 685             


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
    690                 695                 700                 


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
705                 710                 715                 720 


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
                725                 730                 735     


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
            740                 745                 750         


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
        755                 760                 765             


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
    770                 775                 780                 


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
785                 790                 795                 800 


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
                805                 810                 815     


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
            820                 825                 830         


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
        835                 840                 845             


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
    850                 855                 860                 


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
865                 870                 875                 880 


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
                885                 890                 895     


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
            900                 905                 910         


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
        915                 920                 925             


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
    930                 935                 940                 


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
945                 950                 955                 960 


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
                965                 970                 975     


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
            980                 985                 990         


Asp Glu Phe Lys Pro Leu Val Glu  Glu Pro Gln Asn Leu  Ile Lys Gln 
        995                 1000                 1005             


Asn Cys  Glu Leu Phe Glu Gln  Leu Gly Glu Tyr Lys  Phe Gln Asn 
    1010                 1015                 1020             


Ala Leu  Leu Val Arg Tyr Thr  Lys Lys Val Pro Gln  Val Ser Thr 
    1025                 1030                 1035             


Pro Thr  Leu Val Glu Val Ser  Arg Asn Leu Gly Lys  Val Gly Ser 
    1040                 1045                 1050             


Lys Cys  Cys Lys His Pro Glu  Ala Lys Arg Met Pro  Cys Ala Glu 
    1055                 1060                 1065             


Asp Tyr  Leu Ser Val Val Leu  Asn Gln Leu Cys Val  Leu His Glu 
    1070                 1075                 1080             


Lys Thr  Pro Val Ser Asp Arg  Val Thr Lys Cys Cys  Thr Glu Ser 
    1085                 1090                 1095             


Leu Val  Asn Arg Arg Pro Cys  Phe Ser Ala Leu Glu  Val Asp Glu 
    1100                 1105                 1110             


Thr Tyr  Val Pro Lys Glu Phe  Asn Ala Glu Thr Phe  Thr Phe His 
    1115                 1120                 1125             


Ala Asp  Ile Cys Thr Leu Ser  Glu Lys Glu Arg Gln  Ile Lys Lys 
    1130                 1135                 1140             


Gln Thr  Ala Leu Val Glu Leu  Val Lys His Lys Pro  Lys Ala Thr 
    1145                 1150                 1155             


Lys Glu  Gln Leu Lys Ala Val  Met Asp Asp Phe Ala  Ala Phe Val 
    1160                 1165                 1170             


Glu Lys  Cys Cys Lys Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu 
    1175                 1180                 1185             


Glu Gly  Lys Lys Leu Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu 
    1190                 1195                 1200             


<210>  4
<211>  1222
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  4

His His His His His His Gly Gly Ser Asp Ala His Lys Ser Glu Val 
1               5                   10                  15      


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
            20                  25                  30          


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
        35                  40                  45              


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
    50                  55                  60                  


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
65                  70                  75                  80  


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
                85                  90                  95      


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
            100                 105                 110         


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
        115                 120                 125             


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
    130                 135                 140                 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
145                 150                 155                 160 


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
                165                 170                 175     


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
            180                 185                 190         


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
        195                 200                 205             


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
    210                 215                 220                 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
225                 230                 235                 240 


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
                245                 250                 255     


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
            260                 265                 270         


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
        275                 280                 285             


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
    290                 295                 300                 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
305                 310                 315                 320 


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
                325                 330                 335     


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
            340                 345                 350         


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
        355                 360                 365             


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
    370                 375                 380                 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
385                 390                 395                 400 


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
                405                 410                 415     


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
            420                 425                 430         


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
        435                 440                 445             


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
    450                 455                 460                 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
465                 470                 475                 480 


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
                485                 490                 495     


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
            500                 505                 510         


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
        515                 520                 525             


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
    530                 535                 540                 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
545                 550                 555                 560 


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
                565                 570                 575     


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
            580                 585                 590         


Gly Leu Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys 
        595                 600                 605             


Thr Phe Thr Ser Cys Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe 
    610                 615                 620                 


Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly Gly Gly Ser Asp Ala His 
625                 630                 635                 640 


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                645                 650                 655     


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
            660                 665                 670         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        675                 680                 685             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    690                 695                 700                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
705                 710                 715                 720 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                725                 730                 735     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            740                 745                 750         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        755                 760                 765             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    770                 775                 780                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
785                 790                 795                 800 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                805                 810                 815     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            820                 825                 830         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        835                 840                 845             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    850                 855                 860                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
865                 870                 875                 880 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                885                 890                 895     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            900                 905                 910         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        915                 920                 925             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    930                 935                 940                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
945                 950                 955                 960 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                965                 970                 975     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            980                 985                 990         


Thr Leu Glu Lys Cys Cys Ala Ala  Ala Asp Pro His Glu  Cys Tyr Ala 
        995                 1000                 1005             


Lys Val  Phe Asp Glu Phe Lys  Pro Leu Val Glu Glu  Pro Gln Asn 
    1010                 1015                 1020             


Leu Ile  Lys Gln Asn Cys Glu  Leu Phe Glu Gln Leu  Gly Glu Tyr 
    1025                 1030                 1035             


Lys Phe  Gln Asn Ala Leu Leu  Val Arg Tyr Thr Lys  Lys Val Pro 
    1040                 1045                 1050             


Gln Val  Ser Thr Pro Thr Leu  Val Glu Val Ser Arg  Asn Leu Gly 
    1055                 1060                 1065             


Lys Val  Gly Ser Lys Cys Cys  Lys His Pro Glu Ala  Lys Arg Met 
    1070                 1075                 1080             


Pro Cys  Ala Glu Asp Tyr Leu  Ser Val Val Leu Asn  Gln Leu Cys 
    1085                 1090                 1095             


Val Leu  His Glu Lys Thr Pro  Val Ser Asp Arg Val  Thr Lys Cys 
    1100                 1105                 1110             


Cys Thr  Glu Ser Leu Val Asn  Arg Arg Pro Cys Phe  Ser Ala Leu 
    1115                 1120                 1125             


Glu Val  Asp Glu Thr Tyr Val  Pro Lys Glu Phe Asn  Ala Glu Thr 
    1130                 1135                 1140             


Phe Thr  Phe His Ala Asp Ile  Cys Thr Leu Ser Glu  Lys Glu Arg 
    1145                 1150                 1155             


Gln Ile  Lys Lys Gln Thr Ala  Leu Val Glu Leu Val  Lys His Lys 
    1160                 1165                 1170             


Pro Lys  Ala Thr Lys Glu Gln  Leu Lys Ala Val Met  Asp Asp Phe 
    1175                 1180                 1185             


Ala Ala  Phe Val Glu Lys Cys  Cys Lys Ala Asp Asp  Lys Glu Thr 
    1190                 1195                 1200             


Cys Phe  Ala Glu Glu Gly Lys  Lys Leu Val Ala Ala  Ser Gln Ala 
    1205                 1210                 1215             


Ala Leu  Gly Leu 
    1220         


<210>  5
<211>  1213
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  5

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Ala Gly 
            580                 585                 590         


Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly Gly Gly 
        595                 600                 605             


Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly 
    610                 615                 620                 


Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
625                 630                 635                 640 


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
                645                 650                 655     


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
            660                 665                 670         


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
        675                 680                 685             


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
    690                 695                 700                 


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
705                 710                 715                 720 


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
                725                 730                 735     


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
            740                 745                 750         


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
        755                 760                 765             


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
    770                 775                 780                 


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
785                 790                 795                 800 


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
                805                 810                 815     


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
            820                 825                 830         


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
        835                 840                 845             


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
    850                 855                 860                 


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
865                 870                 875                 880 


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
                885                 890                 895     


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
            900                 905                 910         


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
        915                 920                 925             


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
    930                 935                 940                 


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
945                 950                 955                 960 


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
                965                 970                 975     


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
            980                 985                 990         


Asp Pro His Glu Cys Tyr Ala Lys  Val Phe Asp Glu Phe  Lys Pro Leu 
        995                 1000                 1005             


Val Glu  Glu Pro Gln Asn Leu  Ile Lys Gln Asn Cys  Glu Leu Phe 
    1010                 1015                 1020             


Glu Gln  Leu Gly Glu Tyr Lys  Phe Gln Asn Ala Leu  Leu Val Arg 
    1025                 1030                 1035             


Tyr Thr  Lys Lys Val Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1040                 1045                 1050             


Val Ser  Arg Asn Leu Gly Lys  Val Gly Ser Lys Cys  Cys Lys His 
    1055                 1060                 1065             


Pro Glu  Ala Lys Arg Met Pro  Cys Ala Glu Asp Tyr  Leu Ser Val 
    1070                 1075                 1080             


Val Leu  Asn Gln Leu Cys Val  Leu His Glu Lys Thr  Pro Val Ser 
    1085                 1090                 1095             


Asp Arg  Val Thr Lys Cys Cys  Thr Glu Ser Leu Val  Asn Arg Arg 
    1100                 1105                 1110             


Pro Cys  Phe Ser Ala Leu Glu  Val Asp Glu Thr Tyr  Val Pro Lys 
    1115                 1120                 1125             


Glu Phe  Asn Ala Glu Thr Phe  Thr Phe His Ala Asp  Ile Cys Thr 
    1130                 1135                 1140             


Leu Ser  Glu Lys Glu Arg Gln  Ile Lys Lys Gln Thr  Ala Leu Val 
    1145                 1150                 1155             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Lys Glu  Gln Leu Lys 
    1160                 1165                 1170             


Ala Val  Met Asp Asp Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys 
    1175                 1180                 1185             


Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu 
    1190                 1195                 1200             


Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu 
    1205                 1210             


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  6

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  7
<211>  614
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  7

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ala His 
            20                  25                  30          


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
        35                  40                  45              


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
    50                  55                  60                  


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
65                  70                  75                  80  


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
                85                  90                  95      


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
            100                 105                 110         


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
        115                 120                 125             


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
    130                 135                 140                 


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
145                 150                 155                 160 


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
                165                 170                 175     


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
            180                 185                 190         


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
        195                 200                 205             


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
    210                 215                 220                 


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
225                 230                 235                 240 


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
                245                 250                 255     


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
            260                 265                 270         


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
        275                 280                 285             


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
    290                 295                 300                 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
305                 310                 315                 320 


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
                325                 330                 335     


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
            340                 345                 350         


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
        355                 360                 365             


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
    370                 375                 380                 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
385                 390                 395                 400 


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
                405                 410                 415     


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
            420                 425                 430         


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
        435                 440                 445             


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
    450                 455                 460                 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
465                 470                 475                 480 


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
                485                 490                 495     


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
            500                 505                 510         


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
        515                 520                 525             


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
    530                 535                 540                 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
545                 550                 555                 560 


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
                565                 570                 575     


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
            580                 585                 590         


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
        595                 600                 605             


Gln Ala Ala Leu Gly Leu 
    610                 


<210>  8
<211>  621
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  8

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
        35                  40                  45              


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
    50                  55                  60                  


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
65                  70                  75                  80  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
                85                  90                  95      


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
            100                 105                 110         


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
        115                 120                 125             


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
    130                 135                 140                 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
145                 150                 155                 160 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
                165                 170                 175     


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
            180                 185                 190         


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
        195                 200                 205             


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
    210                 215                 220                 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
225                 230                 235                 240 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
                245                 250                 255     


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
            260                 265                 270         


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
        275                 280                 285             


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
    290                 295                 300                 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
305                 310                 315                 320 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
                325                 330                 335     


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
            340                 345                 350         


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
        355                 360                 365             


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
    370                 375                 380                 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
385                 390                 395                 400 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
                405                 410                 415     


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
            420                 425                 430         


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
        435                 440                 445             


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
    450                 455                 460                 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
465                 470                 475                 480 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
                485                 490                 495     


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
            500                 505                 510         


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
        515                 520                 525             


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
    530                 535                 540                 


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
545                 550                 555                 560 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
                565                 570                 575     


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
            580                 585                 590         


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
        595                 600                 605             


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    610                 615                 620     


<210>  9
<211>  613
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  9

His His His His His His Gly Gly Ser Asp Ala His Lys Ser Glu Val 
1               5                   10                  15      


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
            20                  25                  30          


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
        35                  40                  45              


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
    50                  55                  60                  


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
65                  70                  75                  80  


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
                85                  90                  95      


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
            100                 105                 110         


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
        115                 120                 125             


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
    130                 135                 140                 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
145                 150                 155                 160 


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
                165                 170                 175     


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
            180                 185                 190         


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
        195                 200                 205             


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
    210                 215                 220                 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
225                 230                 235                 240 


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
                245                 250                 255     


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
            260                 265                 270         


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
        275                 280                 285             


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
    290                 295                 300                 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
305                 310                 315                 320 


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
                325                 330                 335     


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
            340                 345                 350         


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
        355                 360                 365             


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
    370                 375                 380                 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
385                 390                 395                 400 


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
                405                 410                 415     


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
            420                 425                 430         


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
        435                 440                 445             


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
    450                 455                 460                 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
465                 470                 475                 480 


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
                485                 490                 495     


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
            500                 505                 510         


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
        515                 520                 525             


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
    530                 535                 540                 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
545                 550                 555                 560 


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
                565                 570                 575     


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
            580                 585                 590         


Gly Leu Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys 
        595                 600                 605             


Thr Phe Thr Ser Cys 
    610             


<210>  10
<211>  613
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  10

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
            20                  25                  30          


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
        35                  40                  45              


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
    50                  55                  60                  


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
65                  70                  75                  80  


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
                85                  90                  95      


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
            100                 105                 110         


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
        115                 120                 125             


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
    130                 135                 140                 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
145                 150                 155                 160 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
                165                 170                 175     


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
            180                 185                 190         


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
        195                 200                 205             


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
    210                 215                 220                 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
225                 230                 235                 240 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
                245                 250                 255     


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
            260                 265                 270         


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
        275                 280                 285             


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
    290                 295                 300                 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
305                 310                 315                 320 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
                325                 330                 335     


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
            340                 345                 350         


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
        355                 360                 365             


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
    370                 375                 380                 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
385                 390                 395                 400 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
                405                 410                 415     


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
            420                 425                 430         


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
        435                 440                 445             


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
    450                 455                 460                 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
465                 470                 475                 480 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
                485                 490                 495     


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
            500                 505                 510         


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
        515                 520                 525             


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
    530                 535                 540                 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
545                 550                 555                 560 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
                565                 570                 575     


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
            580                 585                 590         


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser His 
        595                 600                 605             


His His His His His 
    610             


<210>  11
<211>  604
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  11

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Ala Gly 
            580                 585                 590         


Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
        595                 600                 


<210>  12
<211>  604
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  12

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
            20                  25                  30          


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
        35                  40                  45              


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
    50                  55                  60                  


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
65                  70                  75                  80  


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
                85                  90                  95      


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
            100                 105                 110         


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
        115                 120                 125             


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
    130                 135                 140                 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
145                 150                 155                 160 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
                165                 170                 175     


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
            180                 185                 190         


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
        195                 200                 205             


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
    210                 215                 220                 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
225                 230                 235                 240 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
                245                 250                 255     


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
            260                 265                 270         


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
        275                 280                 285             


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
    290                 295                 300                 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
305                 310                 315                 320 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
                325                 330                 335     


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
            340                 345                 350         


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
        355                 360                 365             


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
    370                 375                 380                 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
385                 390                 395                 400 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
                405                 410                 415     


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
            420                 425                 430         


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
        435                 440                 445             


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
    450                 455                 460                 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
465                 470                 475                 480 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
                485                 490                 495     


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
            500                 505                 510         


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
        515                 520                 525             


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
    530                 535                 540                 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
545                 550                 555                 560 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
                565                 570                 575     


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
            580                 585                 590         


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        595                 600                 


<210>  13
<211>  623
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  13

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser 
            20                  25                  30          


Cys Gly Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg 
        35                  40                  45              


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
    50                  55                  60                  


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
65                  70                  75                  80  


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
                85                  90                  95      


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
            100                 105                 110         


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
        115                 120                 125             


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
    130                 135                 140                 


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
145                 150                 155                 160 


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
                165                 170                 175     


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
            180                 185                 190         


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
        195                 200                 205             


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
    210                 215                 220                 


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
225                 230                 235                 240 


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
                245                 250                 255     


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
            260                 265                 270         


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
        275                 280                 285             


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
    290                 295                 300                 


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
305                 310                 315                 320 


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
                325                 330                 335     


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
            340                 345                 350         


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
        355                 360                 365             


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
    370                 375                 380                 


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
385                 390                 395                 400 


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
                405                 410                 415     


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
            420                 425                 430         


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
        435                 440                 445             


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
    450                 455                 460                 


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
465                 470                 475                 480 


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
                485                 490                 495     


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
            500                 505                 510         


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
        515                 520                 525             


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
    530                 535                 540                 


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
545                 550                 555                 560 


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
                565                 570                 575     


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
            580                 585                 590         


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
        595                 600                 605             


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    610                 615                 620             


<210>  14
<211>  661
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  14

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser 
            20                  25                  30          


Cys Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
        35                  40                  45              


Phe Thr Ser Cys Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe 
    50                  55                  60                  


Trp Lys Thr Phe Thr Ser Cys Gly Gly Gly Gly Ser Asp Ala His Lys 
65                  70                  75                  80  


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
                85                  90                  95      


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
            100                 105                 110         


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
        115                 120                 125             


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
    130                 135                 140                 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
145                 150                 155                 160 


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
                165                 170                 175     


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
            180                 185                 190         


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
        195                 200                 205             


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
    210                 215                 220                 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
225                 230                 235                 240 


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
                245                 250                 255     


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
            260                 265                 270         


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
        275                 280                 285             


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
    290                 295                 300                 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
305                 310                 315                 320 


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
                325                 330                 335     


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
            340                 345                 350         


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
        355                 360                 365             


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
    370                 375                 380                 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
385                 390                 395                 400 


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
                405                 410                 415     


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
            420                 425                 430         


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
        435                 440                 445             


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
    450                 455                 460                 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
465                 470                 475                 480 


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
                485                 490                 495     


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
            500                 505                 510         


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
        515                 520                 525             


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
    530                 535                 540                 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
545                 550                 555                 560 


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
                565                 570                 575     


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
            580                 585                 590         


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
        595                 600                 605             


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
    610                 615                 620                 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
625                 630                 635                 640 


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
                645                 650                 655     


Ala Ala Leu Gly Leu 
            660     


<210>  15
<211>  614
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  15

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp 
        595                 600                 605             


Lys Thr Phe Thr Ser Cys 
    610                 


<210>  16
<211>  629
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein, mature protein

<400>  16

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Ala Gly Cys Lys Asn Phe Phe Trp Lys 
    610                 615                 620                 


Thr Phe Thr Ser Cys 
625                 


<210>  17
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  18
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Ala Asn Ser Asn Pro Ala Met Ala Pro Arg Glu Arg Lys Ala Gly 
1               5                   10                  15      


Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
            20                  25              


<210>  19
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  20
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  signal peptide for fusion protein

<400>  20

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  21
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  21

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  22
<211>  40
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  22

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40  


<210>  23
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  23
gctggctgca agaatttctt ctggaagact ttcacatcct gt                          42


<210>  24
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  24
tctgctaact caaacccggc tatggcaccc cgagaacgca aagctggctg caagaatttc       60

ttctggaaga ctttcacatc ctgt                                              84


<210>  25
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  25
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gctta                                                      1755


<210>  26
<211>  5428
<212>  DNA
<213>  artificial

<220>
<223>  mammalian expression vector

<400>  26
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc      960

agatatccag cacagtggcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca     1020

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1080

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1140

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1200

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1260

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1320

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     1380

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     1440

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     1500

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     1560

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     1620

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     1680

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     1740

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     1800

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     1860

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     1920

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     1980

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     2040

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     2100

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2160

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2220

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     2280

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     2340

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     2400

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     2460

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     2520

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     2580

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     2640

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     2700

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     2760

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     2820

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     2880

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     2940

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     3000

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     3060

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     3120

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3180

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     3240

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     3300

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     3360

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     3420

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     3480

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     3540

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     3600

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     3660

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     3720

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     3780

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     3840

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     3900

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     3960

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     4020

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     4080

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     4140

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     4200

cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     4260

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     4320

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     4380

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     4440

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     4500

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     4560

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     4620

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     4680

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     4740

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     4800

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     4860

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     4920

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     4980

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     5040

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     5100

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     5160

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     5220

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     5280

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     5340

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     5400

atttccccga aaagtgccac ctgacgtc                                        5428


<210>  27
<211>  9276
<212>  DNA
<213>  artificial

<220>
<223>  yeast expression vector

<400>  27
agatctaaca tccaaagacg aaaggttgaa tgaaaccttt ttgccatccg acatccacag       60

gtccattctc acacataagt gccaaacgca acaggagggg atacactagc agcagaccgt      120

tgcaaacgca ggacctccac tcctcttctc ctcaacaccc acttttgcca tcgaaaaacc      180

agcccagtta ttgggcttga ttggagctcg ctcattccaa ttccttctat taggctacta      240

acaccatgac tttattagcc tgtctatcct ggcccccctg gcgaggttca tgtttgttta      300

tttccgaatg caacaagctc cgcattacac ccgaacatca ctccagatga gggctttctg      360

agtgtggggt caaatagttt catgttcccc aaatggccca aaactgacag tttaaacgct      420

gtcttggaac ctaatatgac aaaagcgtga tctcatccaa gatgaactaa gtttggttcg      480

ttgaaatgct aacggccagt tggtcaaaaa gaaacttcca aaagtcgcca taccgtttgt      540

cttgtttggt attgattgac gaatgctcaa aaataatctc attaatgctt agcgcagtct      600

ctctatcgct tctgaacccc ggtgcacctg tgccgaaacg caaatgggga aacacccgct      660

ttttggatga ttatgcattg tctccacatt gtatgcttcc aagattctgg tgggaatact      720

gctgatagcc taacgttcat gatcaaaatt taactgttct aacccctact tgacagcaat      780

atataaacag aaggaagctg ccctgtctta aacctttttt tttatcatca ttattagctt      840

actttcataa ttgcgactgg ttccaattga caagcttttg attttaacga cttttaacga      900

caacttgaga agatcaaaaa acaactaatt attcgaagga tccaaacgat gagatttcct      960

tcaattttta ctgcagtttt attcgcagca tcctccgcat tagctgctcc agtcaacact     1020

acaacagaag atgaaacggc acaaattccg gctgaagctg tcatcggtta ctcagattta     1080

gaaggggatt tcgatgttgc tgttttgcca ttttccaaca gcacaaataa cgggttattg     1140

tttataaata ctactattgc cagcattgct gctaaagaag aaggggtatc tctcgagaaa     1200

agagaggctg aagcttacgt agaattccct agggcggccg cgaattaatt cgccttagac     1260

atgactgttc ctcagttcaa gttgggcact tacgagaaga ccggtcttgc tagattctaa     1320

tcaagaggat gtcagaatgc catttgcctg agagatgcag gcttcatttt tgatactttt     1380

ttatttgtaa cctatatagt ataggatttt ttttgtcatt ttgtttcttc tcgtacgagc     1440

ttgctcctga tcagcctatc tcgcagctga tgaatatctt gtggtagggg tttgggaaaa     1500

tcattcgagt ttgatgtttt tcttggtatt tcccactcct cttcagagta cagaagatta     1560

agtgagaagt tcgtttgtgc aagcttatcg ataagcttta atgcggtagt ttatcacagt     1620

taaattgcta acgcagtcag gcaccgtgta tgaaatctaa caatgcgctc atcgtcatcc     1680

tcggcaccgt caccctggat gctgtaggca taggcttggt tatgccggta ctgccgggcc     1740

tcttgcggga tatcgtccat tccgacagca tcgccagtca ctatggcgtg ctgctagcgc     1800

tatatgcgtt gatgcaattt ctatgcgcac ccgttctcgg agcactgtcc gaccgctttg     1860

gccgccgccc agtcctgctc gcttcgctac ttggagccac tatcgactac gcgatcatgg     1920

cgaccacacc cgtcctgtgg atctatcgaa tctaaatgta agttaaaatc tctaaataat     1980

taaataagtc ccagtttctc catacgaacc ttaacagcat tgcggtgagc atctagacct     2040

tcaacagcag ccagatccat cactgcttgg ccaatatgtt tcagtccctc aggagttacg     2100

tcttgtgaag tgatgaactt ctggaaggtt gcagtgttaa ctccgctgta ttgacgggca     2160

tatccgtacg ttggcaaagt gtggttggta ccggaggagt aatctccaca actctctgga     2220

gagtaggcac caacaaacac agatccagcg tgttgtactt gatcaacata agaagaagca     2280

ttctcgattt gcaggatcaa gtgttcagga gcgtactgat tggacatttc caaagcctgc     2340

tcgtaggttg caaccgatag ggttgtagag tgtgcaatac acttgcgtac aatttcaacc     2400

cttggcaact gcacagcttg gttgtgaaca gcatcttcaa ttctggcaag ctccttgtct     2460

gtcatatcga cagccaacag aatcacctgg gaatcaatac catgttcagc ttgagacaga     2520

aggtctgagg caacgaaatc tggatcagcg tatttatcag caataactag aacttcagaa     2580

ggcccagcag gcatgtcaat actacacagg gctgatgtgt cattttgaac catcatcttg     2640

gcagcagtaa cgaactggtt tcctggacca aatattttgt cacacttagg aacagtttct     2700

gttccgtaag ccatagcagc tactgcctgg gcgcctcctg ctagcacgat acacttagca     2760

ccaaccttgt gggcaacgta gatgacttct ggggtaaggg taccatcctt cttaggtgga     2820

gatgcaaaaa caatttcttt gcaaccagca actttggcag gaacacccag catcagggaa     2880

gtggaaggca gaattgcggt tccaccagga atatagaggc caactttctc aataggtctt     2940

gcaaaacgag agcagactac accagggcaa gtctcaactt gcaacgtctc cgttagttga     3000

gcttcatgga atttcctgac gttatctata gagagatcaa tggctctctt aacgttatct     3060

ggcaattgca taagttcctc tgggaaagga gcttctaaca caggtgtctt caaagcgact     3120

ccatcaaact tggcagttag ttctaaaagg gctttgtcac cattttgacg aacattgtcg     3180

acaattggtt tgactaattc cataatctgt tccgttttct ggataggacg acgaagggca     3240

tcttcaattt cttgtgagga ggccttagaa acgtcaattt tgcacaattc aatacgacct     3300

tcagaaggga cttctttagg tttggattct tctttaggtt gttccttggt gtatcctggc     3360

ttggcatctc ctttccttct agtgaccttt agggacttca tatccaggtt tctctccacc     3420

tcgtccaacg tcacaccgta cttggcacat ctaactaatg caaaataaaa taagtcagca     3480

cattcccagg ctatatcttc cttggattta gcttctgcaa gttcatcagc ttcctcccta     3540

attttagcgt tcaacaaaac ttcgtcgtca aataaccgtt tggtataaga accttctgga     3600

gcattgctct tacgatccca caaggtggct tccatggctc taagaccctt tgattggcca     3660

aaacaggaag tgcgttccaa gtgacagaaa ccaacacctg tttgttcaac cacaaatttc     3720

aagcagtctc catcacaatc caattcgata cccagcaact tttgagttgc tccagatgta     3780

gcacctttat accacaaacc gtgacgacga gattggtaga ctccagtttg tgtccttata     3840

gcctccggaa tagacttttt ggacgagtac accaggccca acgagtaatt agaagagtca     3900

gccaccaaag tagtgaatag accatcgggg cggtcagtag tcaaagacgc caacaaaatt     3960

tcactgacag ggaacttttt gacatcttca gaaagttcgt attcagtagt caattgccga     4020

gcatcaataa tggggattat accagaagca acagtggaag tcacatctac caactttgcg     4080

gtctcagaaa aagcataaac agttctacta ccgccattag tgaaactttt caaatcgccc     4140

agtggagaag aaaaaggcac agcgatacta gcattagcgg gcaaggatgc aactttatca     4200

accagggtcc tatagataac cctagcgcct gggatcatcc tttggacaac tctttctgcc     4260

aaatctaggt ccaaaatcac ttcattgata ccattattgt acaacttgag caagttgtcg     4320

atcagctcct caaattggtc ctctgtaacg gatgactcaa cttgcacatt aacttgaagc     4380

tcagtcgatt gagtgaactt gatcaggttg tgcagctggt cagcagcata gggaaacacg     4440

gcttttccta ccaaactcaa ggaattatca aactctgcaa cacttgcgta tgcaggtagc     4500

aagggaaatg tcatacttga agtcggacag tgagtgtagt cttgagaaat tctgaagccg     4560

tatttttatt atcagtgagt cagtcatcag gagatcctct acgccggacg catcgtggcc     4620

gacctgcagg gggggggggg gcgctgaggt ctgcctcgtg aagaaggtgt tgctgactca     4680

taccaggcct gaatcgcccc atcatccagc cagaaagtga gggagccacg gttgatgaga     4740

gctttgttgt aggtggacca gttggtgatt ttgaactttt gctttgccac ggaacggtct     4800

gcgttgtcgg gaagatgcgt gatctgatcc ttcaactcag caaaagttcg atttattcaa     4860

caaagccgcc gtcccgtcaa gtcagcgtaa tgctctgcca gtgttacaac caattaacca     4920

attctgatta gaaaaactca tcgagcatca aatgaaactg caatttattc atatcaggat     4980

tatcaatacc atatttttga aaaagccgtt tctgtaatga aggagaaaac tcaccgaggc     5040

agttccatag gatggcaaga tcctggtatc ggtctgcgat tccgactcgt ccaacatcaa     5100

tacaacctat taatttcccc tcgtcaaaaa taaggttatc aagtgagaaa tcaccatgag     5160

tgacgactga atccggtgag aatggcaaaa gcttatgcat ttctttccag acttgttcaa     5220

caggccagcc attacgctcg tcatcaaaat cactcgcatc aaccaaaccg ttattcattc     5280

gtgattgcgc ctgagcgaga cgaaatacgc gatcgctgtt aaaaggacaa ttacaaacag     5340

gaatcgaatg caaccggcgc aggaacactg ccagcgcatc aacaatattt tcacctgaat     5400

caggatattc ttctaatacc tggaatgctg ttttcccggg gatcgcagtg gtgagtaacc     5460

atgcatcatc aggagtacgg ataaaatgct tgatggtcgg aagaggcata aattccgtca     5520

gccagtttag tctgaccatc tcatctgtaa catcattggc aacgctacct ttgccatgtt     5580

tcagaaacaa ctctggcgca tcgggcttcc catacaatcg atagattgtc gcacctgatt     5640

gcccgacatt atcgcgagcc catttatacc catataaatc agcatccatg ttggaattta     5700

atcgcggcct cgagcaagac gtttcccgtt gaatatggct cataacaccc cttgtattac     5760

tgtttatgta agcagacagt tttattgttc atgatgatat atttttatct tgtgcaatgt     5820

aacatcagag attttgagac acaacgtggc tttccccccc ccccctgcag gtcggcatca     5880

ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat ggggaagatc     5940

gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg gcaggccccg     6000

tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg gcggcggtgc     6060

tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat aagggagagc     6120

gtcgagtatc tatgattgga agtatgggaa tggtgatacc cgcattcttc agtgtcttga     6180

ggtctcctat cagattatgc ccaactaaag caaccggagg aggagatttc atggtaaatt     6240

tctctgactt ttggtcatca gtagactcga actgtgagac tatctcggtt atgacagcag     6300

aaatgtcctt cttggagaca gtaaatgaag tcccaccaat aaagaaatcc ttgttatcag     6360

gaacaaactt cttgtttcga actttttcgg tgccttgaac tataaaatgt agagtggata     6420

tgtcgggtag gaatggagcg ggcaaatgct taccttctgg accttcaaga ggtatgtagg     6480

gtttgtagat actgatgcca acttcagtga caacgttgct atttcgttca aaccattccg     6540

aatccagaga aatcaaagtt gtttgtctac tattgatcca agccagtgcg gtcttgaaac     6600

tgacaatagt gtgctcgtgt tttgaggtca tctttgtatg aataaatcta gtctttgatc     6660

taaataatct tgacgagcca aggcgataaa tacccaaatc taaaactctt ttaaaacgtt     6720

aaaaggacaa gtatgtctgc ctgtattaaa ccccaaatca gctcgtagtc tgatcctcat     6780

caacttgagg ggcactatct tgttttagag aaatttgcgg agatgcgata tcgagaaaaa     6840

ggtacgctga ttttaaacgt gaaatttatc tcaagatctc tgcctcgcgc gtttcggtga     6900

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     6960

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     7020

cgcagccatg acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca     7080

tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta     7140

aggagaaaat accgcatcag gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     7200

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     7260

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     7320

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     7380

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     7440

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     7500

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc aatgctcacg ctgtaggtat     7560

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     7620

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     7680

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     7740

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     7800

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     7860

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     7920

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     7980

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     8040

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     8100

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     8160

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     8220

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     8280

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     8340

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     8400

cgcaacgttg ttgccattgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct     8460

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     8520

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     8580

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     8640

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     8700

agttgctctt gcccggcgtc aacacgggat aataccgcgc cacatagcag aactttaaaa     8760

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     8820

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     8880

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     8940

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     9000

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     9060

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     9120

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattaatt     9180

ctcatgtttg acagcttatc atcgataagc tgactcatgt tggtattgtg aaatagacgc     9240

agatcgggaa cactgaaaaa taacagttat tattcg                               9276


<210>  28
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  flexible, extended linker

<400>  28
ggtggaggtg gctcaggtgg aggtggctca ggtggaggtg gctca                       45


<210>  29
<211>  66
<212>  DNA
<213>  artificial

<220>
<223>  alpha helical linker

<400>  29
gctgaagctg cagccaaaga agctgcagcc aaagaggccg cagctaagga agccgcagca       60

aaagct                                                                  66


<210>  30
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  alpha helical peptide linker

<400>  30

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          


<210>  31
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  flexible, extended peptide linker

<400>  31

Gly Gly Gly Gly Ser 
1               5   


<210>  32
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  linker with thrombin cleavage site

<400>  32

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  33
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  33

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  34
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  linker with thrombin cleavage site

<400>  34

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  linker with thrombin cleavage site

<400>  35

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  36
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  lilnker

<400>  36

Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  37

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  38

Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 
1               5                   10      


<210>  39
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  39

Gly Gly Ser Gly Gly 
1               5   


<210>  40
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  40

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  41
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  41

Gly Gly Ser Gly Gly Gly Gly Gly 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  42

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  43
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  43

Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  44
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  44

Ala Ala Gly Ala Ala Thr Ala Ala 
1               5               


<210>  45
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  45

Gly Gly Gly Gly Gly 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  46

Gly Gly Ser Ser Gly 
1               5   


<210>  47
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  47

Gly Ser Gly Gly Gly Thr Gly Gly Gly Ser Gly 
1               5                   10      


<210>  48
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  48

Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25      


